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                    <text>January 25, 1968
Dr. Edwin D. ”0113mm

PartyJ'ivc Hmdmd West Pina#500 West Pine" Boulevard
51:. 11min, Hisowri 63108
Bear I)? .

Clinic:

Wolfm:

0mm
Mmmmadmmmllmtoyou.
Kins

boonwithus since Septomer 27, 1965.

Mngﬂmfimt fmmm,mmrtookanmaf

investigatimm . mass were not inconsistent with
1mm
Wtim ﬁxat she be treated with imipmaﬁne, active

the

occupational therapy and early mhabilitation.

Dmimﬁnfmtfwmshebemmamdousmd
oomlaints.‘ By- the
men

amazed my

mtic

fifth week,

themedicationhadbeenimaaedto 225mandﬁ1en’ao

mlainta
for

per day, these
absent except

a

300mg

became less prmdnant and have been
single week when sh: couplaimd of "fainting."

Wmmhwmodhmbeenheightexm,heraffect
approprhte, and sham wound productively and actively in
m
oompatiaulthampymdinﬁwﬁmlabomtoxy. Shehaebeen
“anagram
WMvisitsforpwiodsuptoﬁwdnya.
gme well and except for an occasional whim: of increased
exudatymfmmarthemdofmstay, sheexpmsses
mpoatadlyﬂn desire

1:0

mm this mmt.

Whaveemoumgedhartooontimhersdmlingwhile

mining at the hospital. At pmt she has sane reluctmm
tommtakeasdmlpmgrmonapartﬁmbasis, butwempe

.mtahewillbeableiomaka this adjustmnt.

Simuly yom's ,
Max

Pink,

14.1).

,meesm of Psydmiatry

�</text>
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                    <text>Dualibcr 19th, 1972
Benjamin 3. Hblnnn, K.D.,
66 strum , Suite 613.
just
new York. H.Y. 10023.
.10

Dm-

mm aroma,
Thank

in“ very

'mxozpuc
m m- 1.th aaf‘nnntal
disorders.

in your hsnabook tor trontnnnt

mothodn

ma

I regret that I an andble to cut aside the tins at
yrcoont to andcrtake such a sun—pry. abould the finlncial
_arrtngunonsl for such a yorticipatian ha significant, I
vauld be glad to reeaunond nun of my associates whoa I
bclieva is capdble of doing the 36b. 1 would hesitnto to
nth hia unlois I warn dbl: to compensate htm for the
tin. involved, sine. ha docs haw. a practice.
Sincerely yourt.

ﬁnk, 24.».
m
Professor of Paychiatry
HiliJ

�</text>
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                    <text>ﬁarch 31, 1972

Dr. Geoffrey Woodard
12310

Pinecreat

Road

ﬁclndon, Virginia
Dear Dr. woodard:

files, we found the enclosed reprints and
us by Racket: &amp; Colman in 1970. These may be useful
in your evaluation of H-5050.
In checking our

raports sent

The letter of authorisation
sent earlier this week.
we

look forward

ta hearing

and our supply of M—SOSO‘wére
from you.

Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

ﬂF:1g
Enc.

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                    <text>necember A, 1972

Jaw/M0,

(2&amp;3)

léé-S

Geoffrey woodard, Ph.D.
Pharmacologiat
Uoodard Research Corporation
12310 Pinecreat Road
Herndon, Virginia 22070

Dear Dr. Woodard:
While I believo the City of Rev York will eventually honor
seemed prudent to avail ourselves of the good offices
~ with the hope that they will, either by the majesty of
of
their office or by direct support, gain reimbursement for your efforts.
I have called Dr. Alan Green of SADDAP and asked him to advise ua
as to what they can or may wish to do to aeeitt no in making your
data available for an IND filing.

its contract, it
SADDAP

I anticipate receipt of the report you sent recently. Mean~
while, in anticipation that Mr. Heet canvsupply the documents that
the City, through ite agent Mr. Jacobo, uiehes nrior to payment,
I would ask that these be supplied directly to our fiscal officer,
tire. Waldov.

I

an

optimistic that theae issues will be resolved,

forward to testing diprenorphine in man.
Many

thanks for your

efforts.
Sincerely yours,
Mex

Fink ,

31.13.

Professor of Psychiatry

Ming
cc:

Alan Green,

SAODAP

George Jacobs, REC-NYC
Hrs. L. Haldov, NYMC

and look

�</text>
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                    <text>._,...v—‘w..y,ww‘.rﬂg.n

v

March 26, 1964

Dr. Goofftoy Woodard
Pharmacologtot
Ubodntd Research Corporation
P. 0. Box 405
Korndon,

Virginit

Dear Dr. Woodard:

Enclosed in on order from tho Psychiatric Rooeoroh
Foundation of Missouri, submittod at tho toquoot of
Dr. Samuol Gorahon. for the preclinical sofoty evaluon
tton of p~Phoayl wandeltc Acid iaHOI. following the
proposed ptotoool submitted by you on January 31. 196k.
You will not. that tho order specifics oitbor the oon~
comitant or serial touting 1n aloe. rots, rabbits, and
dogs. acoording to your eatinote.

m...“—

Sincerely yours,
pwawmm...

‘-w

n...

an: Pink,
Director

-.~,..—.wm

,5.

,

.vawrﬁfq

,

sou—w.“

rum

wan-x»

MF/jb
Em: o

M.D.

�</text>
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                    <text>September 13, 1967
Dr. Edward Woodward, Jr.
Robins Company, Inc.

A. H.

1407 Cummings Drive

Richmond, Virginia 23220
Dear Dr. Woodward:

for your letter of September 8.

I think your
in
the protocoi for the investigasuggestions regarding changes
tion of fenfluramine are most heipful and acceptable. Piease
alter the protocol and send me a copy.

Thank you

Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>.‘

Y'ﬁes-«v'w

Irraw-

February 12, 1970
Dr. Edward Woodward,
A. H. Robins Company
1407 Cummings Drive
Ridhmond,

Virginia

Jr.

23220

Dear Dr. Woodward:

fcnfluramine-behavior study (#0761) was undertaken
following our observation that the EEC profile was more like
amobarbital than dextro-amphetanine. Since we had no prior
experience with studies of weight reduction and anorexia, we
proposed a study to observe the behavioral effects of fenfluramino
and placebo. Since this was not feasible without a protocol, one
The

was

filed.

double-blind, with neither the subjects nor
the observer aware of the medication given.
Tﬁe study was

In tho

during the

subjects, sedation and somnolence occurred
first few
2—4
days of drug trial, and did not with placebo,
initial
which

by the

1.8.,

reports of the subject

we

were able

medication they received. We confirmed this
breaking the first 7 codes.

after

to discern
7 subjects

by

An

analyses of the behavioral data indicated that sedation

At

this point,

was indeed the most prominent symptom.
we

cases. found only one
Since

we

were

continued the study and with succeeding

reporting stimulation.

ill-equipped to

questions of weight reduction,
difficult group of subjects.

we

answer the many

relevant

had prohloms in managing

this

In a telephone discussion, I indicated that I was satisfied
with the behavioral data, remarked on the difficulty with the
weight reduction aspects, and recommended the study be discontinued.

�//-

Dr. Woodward

With

February 12, 1970

~2—

this badkground, the following are Specific answers

to the questions:
1.

Study was double-blind.

Crossover resulted from a desire to assess the
differences, if any, in behavior. Also, since the subjects
signed a permit that included "placebo“, at the end of the study
they inquired whether they had received "drug” or “placebo”. For
the pationts who received placebo, a trial of active drug was
2.

offered.

3.
4.
I

\soo notes this letter.
Supplioﬁg see attached.
FDA:

trust this is reogonsivo and usefbl.
it Siggoroly yours,
'5.“

Fink, H.D.
Professor of Psychiatry

Max

‘

Mszp

/‘\\

//A7[\Jx7

�</text>
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                    <text>September 2h, 1969
Dr. Edward Woodward,

A. H. Robins Company
1&amp;0? Cummings Drive

Richmond,

Jr.

Virginia 23220

Dear Dr. Woodward:
The

effects of fenfluramine, amobarbital
in its entirety.
has been described in the following reports:

report of

EEG

and dextroamphetamine has not been published

In part,

it

Electroencephalography, Mental State and
Psychoactive Drugs, in Pharmacolo for
Physicians, W. B. Saunders, Phil., 3255: 1-5, 1969.

Patterns as an Index of Clinical Activity
of Psychoactive Drugs. Electroenceph. clin.

EEG

_,«

-,

7-wa‘:‘;u§d'v

mag-n

V._.,_._....&lt;

WW.

(abstract) 1969.
A complete repott is being typed for submission to the EEG Journal.
The fenfluramine - reaction time data has been reported at
various meetings by Dr. Itil but, as yet, has not been published.
Neurophysiol., 27:

710

Sincerely yours,

:w/ﬂ-anw—«wvw'x

-

*anw'b

Max

4

-

,/

Fink, M.D.

Professor of Psychiatry

wr&lt;rv=fuu77

MF:kp

enc .

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                    <text>W5
I—»

¥1

,’

v-

("

MWwW

September 26, 1978
TO:

HON.

Mr.

Justice

Royal Commission
New South Wales
FROM:

Woodward, Commissioner

into

Drug Trafficking

Fink, M. D.
Professor of Psychiatry
School of Medicine, State University of

Max

I

am

New

York

at Stony

pleased to respond to the invitation to discuss

with dependence producing drugs to assist the Commission in
regarding the trafficking of proscribed drugs.

My

its

my

Brook

experience

recommendations

experience is based on

a six year study of the pharmacologic effects of cannabis and cannabis

derivatives, both in volunteers in the U.S.

and

in chronic users in

Athens, Greece. I have also studied the efficacy of narcotic antagonists

in the treatment of opiate dependence. In these studies, begun in

1966

and continued to 1973, I have administered heroin, methadone and levomethadyl

to opiate dependent subjects;

and examined the pharmacologic

interactions of the narcotic antagonists cyclazocine

effects

and

and naloxone with

opioids.

I am.Professor of Psychiatry ate the School of Medicine at the
State University of

New

York

at Stony

Brook. At the time of the

studies

discussed today, I was Professor of Psychiatry and Director, Division of
Biological Psychiatry at the

to the National

New

York Medical College; and a consultant

Commission on Marihuana and Drug Abuse,

the Veterans

Administration, and the National Institute on Drug Abuse.

‘

�this time permit

At

me

to

make

a number of generalizations

about the pharmacology of these compounds. There

distinction between opioids
apparent in the studies.

administration of the opioids, even under

controlled conditions, is fraught with risk.
into stupor

Our

and evinced grand mal convulsions

which we deemed safe

an important

is immediately

and cannabis which

The

is

subjects have fallen

after dosages of heroin

for the individual. Seizures occurred in three

suffiently striking for us to report it
in the scientific literature. In my clinicial experience, three patients
subjects, a finding that

was

died on our wards after opiate overdoses. In two instances,

antagonist.
and

and administered naloxone, a proper

the proper diagnosis

made

But our dosages were not sustained with

the subjects died during the night.

on our ward. He was
some

A

Such

programs in

tales are

New

common. There was a

still

new,

city, It

was

York were

almost every day in the

a young addict achieviaggthe age of

that

A

we

young man

visitor passed

The dose was

anticipated (or his tolerance had been reduced
died during the night, on a medical service.

narcotic

methadone was drug-free

to be discharged the next day.

heroin which he injected that night.

had

sufficient frequency

third instance, a

detoxified by decreasing doses of

who had been

we

him

higher than he

by our treatment) and he

time, when the methadone
read of a methadone death

said then that the likelihood of
30

if he were taking

opioids at the

age of 21 was less than ﬁne in ten.
By
We

contrast,

we

have found cannabis to be

relatively benign.

have reported the central nervous system effects in

as well as the development of

its administration

tissue tolerance; but the principal effects

�-3in_the cardiovascular and nervous systems are well tolerated, well
within the ability of most subjects to accept and survive.
For

this difference alone, the response of Society to cannabis

ought to be different than the response to opioids.

In the studies of long term users of hashish in Athens,
were

struck by their focussed interest

on cannabis (hashish). Despite

the fact that they had used hashish for more than

interest in
smoke

we

and experimentation with opioids was

20

years, their

insignificant.

They did

tobacco in large quantities and did use alcohol. In no instance

to

were we able

document

the

combined use of hashish and opioids. While

such obserbations are not compelling, they do suggest

that the connection

is probably not inherent in the pharmacology
of the drugs, but in the propinquity of the distribution systems. If one
is looking for a synergistic use of drugs, we can suggest that cannabis
between opioids and cannabis

'and tobacco are

clearly used together

Perhaps the most

antagonists.

3

When

/

I

first

by long-term

users.

interesting studies are those with narcotic
became acquainted with

the subuect of opiate

dependence, four competing theories of treatment were current: abstinence

after detoxification, abstinence in the

framework of group therapy,

cross tolerance to methadone, and blockade by narcotic anttgonists,

chiefly cyclazocine. Abstinence after detoxification

was a temporary e

expedient with an unacceptable relapse rate; abstinence in a group therapy

setting

was

helpful to a very small

to implement.

The

sample of users and very expensive

principal treatments

antagonists. working with

were methadone and

methadone and

its

the narcotic

long acting analog, levomethadyl,

I found these regimens of limited usefulness. Proper use of

methadone did

not preclude the use of other drugs such as opiates, barbiturates, alcohol,

�and cocaine, and
methadone

these drugs

into the

some

find

extensively. Spillage of

additional source of opioid deaths

community was an

and dependence. we did

in

were used

substitution useful

methadone and levomethadyl

patients, but our successes were

few

--- too

few

or to be considered a success in relation to our costs.

to be gratifying

Our

greatest

energy was dedicated to cyclasocine therapy, which I thought was a

logical treatment
detoxified

and

this regimen, patients are first
in a drug-free state, are gradually

and prophylaxis. In

after a

few days

introduced to single daily doses of cyclazocine. This narcotic antagonist
has a long duration of action and after a few weeks, single doses of
four to five

mg

are sufficient to block the effects of

heroin for more than

2h

hours. Thus, patients

who

up

to

are on a maintenance

dose of cyclazocine have no euphoria or sense of well being

heroin and

we

25 mg

after

believed that this negative reenforcement would lead

to disuse of heroin

and eventually

to

an end of dependence. But we

found many problems with the treatment, the principal one being the
5

2

.;

need for voluntary comjliance by the subject

daily for a

number of

years,

and few

---

he must take the medication

patients are so cooperative as

to complete a satisfactory treatment course. Lately, other antagonists have
been studied, the best known being naltrexone, which is safer and easier
to use than cyclazocine. The reason for raising the question of the
antagonists is the perspective they give to the medical management of

opiate dependence -— there are

ways

to treat dependent subjects but

each method ultimately depends on the cooperation of the subject,
something

that is difficult to achieve.
These experiences with users have made me

our

ability to solve the opiate dependence problems

pessimistic about
by

present medical

or legal means. Opiates are dangerous substances and they should be

�-5controlled in their distribution.

One wonders, however, whether

driving

users to the streets has been successful, and whether relaxing controls for

greater medical usage

may

not have

some

benefits. I

am

acquainted by

reading only with the mixed picture presented by the English regulations

for the use of opioids, and despite their difficulty, on balance I think
that they are more sensible than the laws in New York, where phsyicians
are enjoined from using opioids other than for methadone maintenance in

established clinics. I think the present rules
away from any

the

illicit

experience with opioids and

have driven most

made most

ptactitioners

users dependent on

marketplace.

Finally, the

most extensive experience

I have had is with

chronic users of hashish in Athens. There, a team of scientists from the
New

York Medical College and

to study a group of
The

worked

together

h? hashish users and a matched sample of

controls.

users were the survivors of a larger sample of chronic users of

hashish which
‘

the University of Athens

at the

was known

to the scientists at the University of Athens

end of the second World War.

We

found

that the users

showed

little

toxicity -- they were no different from controls in medical
or neurologic status, or in tests of brain function. There were some
differences in psychologic tests which seemed related to their education.
evidence of

individuals

classify as psychopaths -they were willing to flaunt the law for gratification of their senses.
We did find that they had developed a tolerance to the pharmacologic
But they were

effects of cannabis.
150

mg

we

would probably

They could smoke hashish containing more than

THC-delta—9 and develop

greater than the effects of
doses (over 100

mg

in naive subjects.

10

euphoria and cardiovascular responses no

to

20 mg doses

in our volunteers.

Such

THC-delta-9) are known to cause vascular collapse
we

attempted to demonstrate withdrawal symptoms, but

�-6the subjects were willing only to remain under our care for three days
without smoking cannabis. In this time, we could not demonstrate the

classic signs of physiologic withdrawal, but then, perhaps, their

inability to cooperate was in itself a symptom of withdrawal.
The conclusions of that study were many, but the principal
one was that we had failed to find evidence of toxicity for cannabis use.
Similar dindings in CostarRica and Jamaica reassure us that our
very

observations were not spurious. Further studies of this nature were
reported at the conference on chronic hashish use held in 1976 at
the

New

York Academy of Sciences (volume 282).

These are

my

experiences. I have lectured often on the

problems of cannabis use, and I have come to believe

that the greatest
risk in my community from the use of cannabis is the risk of legal
penalties and imprisonment. There is also a risk of other substance use,
since the present distributors of cannabis are acting in defiance of
the law, and they seem as willing to

sell

cocaine, and other abuse substances as to
which

legalized alcohol

and medical

risks

-—

and tobacco

same

on

distribute opioids,

sell cannabis.

A

society

substances with well defined toxicity

should legalize cannabis as well. For consistency,

prescription of cannabis should be
and alcohol;

-—

and

accompanied by

legalization of the latter

proscription of tobacco

two drugs should lead

to the

treatment for cannabis. There is no other rational position based

the available evidence.

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.~.\.'-...W—y-z

1-,...

W.

.rww-ﬁ

,..-y~..m~.-yy

—..,vn,vs‘:vx

u
’

vww-wsmw‘vca‘“

n-n

"“4."-

March 6, 1967
Dr. J. J. Wbodward
Manager, Research Computer Center
The Upjohn
y
Kalamazoo, Midhigan #9001

‘

Dear Mr. Wbodward:
I.am disappointed in not being able to attend the DIA
Computer Workshdp. I hepe that you and IBM will make such

a discussion available again in the near future.

I have been interested in various applications
of digital ccmputersto psychopharmacology. A.principal focus
has been in the analysis of EEG signals. But, in establishing
the computer facility at the Missouri Institute of Psychiatry,
I encouraged my associates to develop a model information
retrieval system. we were able to code more than 1,000 documents
from my files and these provided the basis for an interesting
demonstration both in Missouri, and at the world Congress of
Psychiatry in Madrid. Both the limitations and advantages of
this system became obvious, but since it required additional
funding, I have not pursued this further at present.
I am taking the liberty of enclosing a description of
our system. I hepe that it will be possible for us to meet
at the Association meetings, and perhaps at the next DIA
Since 1962

WbrkshoP.

-

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>Deeenber 29, 1966

Phyllis

Mm.

Woodward

Convention Manger

American Psychiatric Association
1700 - 18th Street, NM.
; Washington, D. c. 20009

Become.

,

WOW:

I an enclosing the Scientific Exhibit Application form for
in Detroit. Became this exhibit
considerable electronic equipnent, I have been advised by the IE“!
representatives that six foot depth is probably too net-rm and
that twelve foot should be requested. Since the equipment will
becpe'mting, theavailebilityofuptofortyfootwillpmvide
sufficient space for accanmdatim of the service personnel.
the

1967 APA meetings

Wewillrequizeatitlesigm,but1wmldliketoreeerve

this oollebwation for. a

few weeks

until we

have had an Opportunity

to outline the remainder of this exhibit. As soon as this is done,
Imuldlihetosendymsanedmwingsmdadecisioncenthenhe
made as to the mceeeam sign.
‘

Thank you

for your cooperation.

.

Sincerely yours,

.

Mqu)

Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>February

Phyllis

Mrs.

8,

1967

Woodward

Convention Manager

American Psychiatric Association
1700 - 18th Street, N.W.
Washington, D.C. 20009

Dear Mrs. Woodward:

It is with great regret that my associates and I mast with—
the denomination "Application of Digital Gangster Analyses
of the EEG to Psychiatry," ﬁrm the 1967 APA meeting. I have
already notified the exhibit managers by telephone, and ask that
you accept this letter as a formal withdrawal.
.

draw

When we

originally planned the exhibit,

we

anticipated

danonstrating the programs and equipnent nm available in
Missouri. This equipment is no longer camercially available
and we were unable to obtain it for the demonstration. In
its stead, IBM proposed that we
use the new system, their
IBM

1800.

ment

Ordinarily, this

would have been

acceptable, but the equip-

ismwandstillhasmtbeendelivemdtoNewYorkformm

use in rewriting the program. In view of the short time available
in preparing the demonstration, we did not feel that we could

present a satisfactory program.

-'

We do feel, however, that the 1800
system will be operational
at the New York Medical College by the end of the year. If that
is so, I anticipate that we will reapply for such a demstretion

in

1968.

Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr. Frazier

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                    <text>Novumber 30, 1968

Dr. Dean E. Wooldridge

California Institute of Technology
Borkolpy, California
Dear Dr. ﬂooldridgc,

I

am

writing to roquont permission to use a paragraph

from your volumo, ﬂochanictl‘ggg , II an introduction to an article
that I on writing at the request of
tho editors of Pharmacologz for

thoioians. I wish to quote tho paragraph ending the summary of
Chapter 14, on page 156.

I have read the thrac volume: of your views of
biological science with considerable intorost. Our own studies,
devotod to nonsuromnnt of tho changea in brain function and in
behavior associated with the administrntion of drugs and biological
trnataont of the mentally ill, have led on to the conclusion that
small alterations in cerobral chomiutry do, indcod have profound and
monournblo

affects both

on the scalp rooordod EEG and on interporaonol
revicu for which I requcot permission to quote your
summary, is the result of out atodies and those of others and in
consistent with your message.

behavior.

The

Thank you

for your oooporation,

intorelting expositions.

and

congratulations on your
Sincerely yours,

‘,

,o.w;wk...v

Fink, M.D.
Professor of Psychiatry

Max
"

‘
-

’7”

“33"“

'-"-’-

WW

:

-‘=

"

w‘v‘r

2"”-

Wan-er-er-v

mf/

�</text>
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                    <text>Novmbar 2, 1963

Miss

woomr

Pauilitatiw Swim

Wt
W,
Burma
Office of

munch

Claim
Wang:
Status
of

D. C.

War:

Myouvcrynwhfwywhlpwhnlmlhdlutmok.am enclosing an official application and supporting
mesumitmyadditiomlinfomtimuuyhomuimd.

We.

I

Thank you very much

for your

mum.

Sinmly yours,

Mr
Max

Hme

W.

Fink; H.
‘

D.

�</text>
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                    <text>Fcbtuary 8.

1965

Hrs. Virginia It Word
Dopnrt-nat of Bonn: Cusp.
Building 6 5555 Ovnrlsnd AﬂIﬂﬁ.
8:: 31:3». California 92123

has: Virginia:

It was sic: halting

I an 916.106 to uand you
th. ”r‘vurnc” fern as wall.
I Icnln.
will find that an. seal. and its us. in discribed in

copios of ab: Californin

I think

you

{run you. and

mmmm
a

upon written

by

and

a, unuiau,

Robert Kuhn, in tho

m: “7‘1”.

1950-

M

g;

Aftor many nontha of dithering. our laboratories are now
part a! ch. School of Hidieinn at ch. University of Missouri.
600:3. has acenptcd thc position as Chairntn of tha Department
and all tbs stain: numbers have beau appointad to the university
faculty. Ia nddition, tho labatatotios are now almost complete.
and it are, rnally for tha fitnt tine. functioning as a major
raaaurch eentor.
Hy

bust regards to You.
81n¢erely yours,

3‘: link.

M.D.

Protects: of Psychiatry

3183:

�</text>
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                    <text>November 20, 1979

Dr. Henry H. Work, H.D.
Deputy Medical Director

APA

1700 Eighteenth

washington, D.C.

St.

N.W.

Dear Henry,
EEG

Thank you

Society guidelines

for the opportunity to
in

EEG,

1976.

comment on

the American

Clinical electroencephalography is a discipline which is
more than 50 years old. Mich information has been extracted from EEG
recordings by clinical and research neurologists and psychiatrists; and

yet, there remains a divergence of opinion in different centers retarding
the applications of this methodology. The disagreements are not related to
technical equipment, since these are quite sophisticated and reasonably
foolproof. Much of the discordance seems to relate to the differences
in montages used, controls for recording, location of electrodes, and
measurements made. The awareness of the divergence in skills of recordists
and eiectroencephalographers led.the American EEG Society to establish a
Board for qualification, training courses for recordists and readeree and
these guidelines.
The guidelines are an amalgam of many opinions, and there
are many fine points with which one could argue. In breadth of detail,
in sensitivity to the need for adequate training and the realities of
what the marketplace would hear, and as a service to our profession, the
guidelines seem excellent and servicable. I believe they should be
adopted by the APA,~and recommended to our membership. There are many
institutions, particularly those proprietary hospitals without academic
affiliations, and the State and V.A. hospital systems which may find the
recommendations onerous, even expensive, but in fairness to their patients
and with the optimism that the best medical care should be provided all
Americans, these guidelines are a small step in upgrading an important
service.
I

recommend endorsement.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>February 26, 1971

Secretariado Del

V

Mundial de

Congreso

Psiquiatria

Apartedo Postal 20—123/24

Mexico, D.F.

Gentlemen:
WCP

in

for

2

Enclosed

is our

Mexico City.

check

for $60.00 fOr

membership

in the

I wOuld also appreciate a reservation at the Camino
for arrival Sunday, Nohember 28 to December 4, 1971.

I have already accepted the invitation
symposium "EEG Correlates of Psychiatry."

Real

to participate inthhe

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1971

�</text>
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                    <text>r

March 29 , 1967

”1:4”...va

w

;

E-

E

E

i

g

:
E

J. Worﬂxingtm
Street
51012
Iowa
crumbs,

Dr. John

802 Walnut

Dear)». Worthington:

Wehavereoeivedaoopyofyamcm'zdculmvitaefmtm

'DothanlbyAssooiates. 'meChaimanoftheDepar'mnnt,
Dr.A1fmdM.PreednmandeillbedttMAPAmﬁngsin
Detroit. Ifymplantobetrm,1wouldbepleasodto
mangetometwithym. Iwillbestaymgatthelbtel
Pomlm'train

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

F
3

MF:kp

cc: Dorothea Bmlby

�</text>
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                    <text>Juno 1, 1964

Dr. Joseph Hortia
Division of redistric Psychiatry
The Jewish Hospital of Brooklyn
555 Prospect Place
Brooklyn 38,

New

York

Dear Joe:
Following is my designations for the contributors in
the forthcoming volumc:
M. D., Director, Missouri Institute
of Psychiatry

ﬂax Fink,

Research Professor. Department of Psychiatry,
washington Univorsity School of Medicine,

St. Louis, Missouri.

.V

Sincerely yours.

JFM

-mitfu'ék

Ha: Pink, H. D.

Director

HIV/5b

�</text>
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                    <text>my 25,

1965

Dr. Joseph Harris, Editor
Recent Advm in Biological Psychiatry

Wyn

The «wish Hospital of
555 Prospect Place
Brooklyn, New Yark 10938

Dar

Dr.

.

Vania:

Enclosed am the amtrimtims of the panelists who
participated in the 15mm on ”Midwlhurgic Hanucinogms"
on Hay 1. m1: includes omtﬁhxtims by Dru. Abood. German,
and ﬁlm... m. Wilsm has submitted his paper in
Itﬂ,
two parts for publimtim, indicating that he
the
data from both reports in this

“to

Wand

swim.

Imalaoemlosingme inmmrymrkawhichlwas

umblotomad. Ibeucveﬂutﬁzissumﬁzesthebackrwxd
for the armor papers. I have chockad these reports and have

and my“! to mat the nuisances

so that they follow

aamotylcas Buggesmdbyymmmmmndm. Ihave
corrected some of the references and have mported my corrections

to :2: authors. I twat that this will
r.

as

Inadditim,

laboratory, byDr.

than

mice your

editing job

final obpieaofthehmmportsfmmis

Itnandbymyselfmalaomalosad.

ItMeMnapleammingwithyoumItmtmt

mmmmmmmimuappml.

Sincerely yows.
that Fink,

M. D.

Professor of Psychiatry

�PAPERS SUBMITTED FOR PUBLICATIQ‘

"W

ADVANCES

IN

IN BIOLOGICAL PSYGIIATRY"

6.: Apsycrnsis-pmcmcing drug as a tool in studying

Abocd, Inc

mm emitstim.

Pink,

24.:

Cholinergic mchenism in mental illness: anticholinergic

lullucinogms.

SW1: The behavieml effects of enticinlin‘ergic psychotaninetics
their mtegmists in men and animals.
induced by enticholinergic drugs
11:11, Man 14.: Quantitative EEG 0
and their behavioral correlates

Gershm,

and

mm.

Richard P.:

activity.

We

Spmdlin, w. w.. Stembem,

w.

and behavioral signs of enticholinergic

c. A., Wilson,

MtieMlinergic Hallucixmie I:
m the "undue spindle"
the hippocamws in cats.

plum

Stembergh,

W.

C.

w.

P., and Hughes, J. I»:

effect of atropine and JB-329
and the electrical activity of

The

A., and Wilson, W. P.: Mticholinergic Hallucirmis

marveticm m the effects of etmpine and

JB—329

on

II:

the activity

of the visual system, ram-specific projectim system and hippocamus
in animls with and without reticular system lesicns.

Pink.

it, Itil, ‘1‘., and Clyde,
qumtitetive EEG

W8.

1).: The

classification of psychoses

by

Keekiner, A.. and Pink, 14.: damages in psyclnpethclcgy
related to qmtitetive electzwucephalogmphy.

11:11. '1'. 21..

'

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                    <text>June 20. 1968
Dr. Joseph

wertis. Chairman

Editor of 1967 Transactions
152 Hicks

Brooklyn,

Street
New

York

Dear Joe.

Enclosed is a draft copy of our article from
the meeting on Saturday in washington.
Dr. White

will

be spending the next year in

the laboratory of Dr. Phillip Bradley in Birmingham.
the galleye are available it would be useful if
you would send me a set for you may get them quicker.

When

My

best regards.
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

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                    <text>ﬁvw—

m‘TVWW,a-wmm W

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n

,i‘.

v

7,“ ,__,

,

.‘..,,U_.

,7

WW

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A.

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.

Hawsrqu-m—_d r-r.‘ --../~

var—1......” ‘Ivuwvf‘v-"W’Y"w

mun-JW‘V

our." WF—Vva—l—

January 22, 1969
Dr. Joseph Wortis
Department of Psychiatry

Mamnides Hospital

3

é
u

I+802 Tenth Avenue
New York, New York

11219

rurzm‘r-NW‘V"

.

"WWW

Dear Joe,

I am pleased to submit the report ”Puerperal Schizophrenia,
Physiological Interaction Between Mother and Fetus” by Drs . Taylor
and Levine for your consideration for the first issue of Biological

A
—-;'—“W’

u

"‘qux

-r
‘-

Wm

P45

ychéauy.

I hope that the work of these two young men , which has been
of particular interest to ‘Al and nyself can appear in your first
issue, as I think this material is both timely, significant,
and particularly related to the message presented by our former
president , Hudson Hoagland.
Good

rV

luck in the journal.

an”

Sincerely yours ,

mum

nov-

Fink, MJ).
Professor of Psychiatry

Max

TNWF-"I‘I‘V'.

NF :kp
nxmmu-v—wrv

W”;

W

. ,

w

~

�</text>
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                    <text>~._-.—,-.m—w- ,,.- 3:“-:v

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L &gt;7.

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.

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June 11. 1969

nwvlr‘r‘

.A-

m

..

nut-mm

Dr. Joseph Hortis
Haimonides Comun‘lty Henta1 Hea1th Center
4802 Tenth Avenue

Brooklyn.

New

York 11219

.

Dear
“rue—V...“

aw

m?

W

yw;vm-wwm.m—rnr'us—m

7mm“.

.Aer

u...“

v_,;.v.e

b'wv‘.‘

Joe.

report “The Cerebrai Reactivity Modei in Schizophrenia
Re-Appraisai' was not presented at the Society of Bio1ogica1 Psychiatry because we had not comp1eted the ana1yses in time.
It is un1ike1y that I wi11 have the paper ready within the next
few months and suggest that you de1ist this
report.
The

A

Sincere1y yours,

Fink. M.D.
Professor of Psychiatry

Max

rt _,,,_,,

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v

�</text>
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- m1 .. Wan-WV
w

V.

m.m.r.mw—\-»

.wm— mvv'qv'V‘w

—.

unqmu

“VA-‘1'."

May

12, 1971

Dr. Joseph Hortis
Department of Psychiatry
Meimonidos Medical Center
4802 Tenth Avenue
Brooklyn, New York 11219
Dear

Joe,

to have your Board review our
believe that the content is too clinical and
inadequately quantitative or chemical to be accepted in
While I would be pleased

report

on ECT, I

Biological Payehiatry.
Thank you

for the invitation.
Sincerely yours,
Pink, ”.9.
Professor of Psychiatry

Max
NF

:kt

�</text>
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v'

;
Vv'r:wvuv

av“?

—-——|v~mr-‘;mmrl

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.957

-

.,,w

a

October 14, 1971
x:r-v

M’WIWVw-‘r

Dr. Joseph Wortis
Maimonides Medical Center
Brooklyn, New York

.'
«v—

Dear Joe,

I regret that we are unable to supply the manuscript
"Contributions of Unilateral and Multiple ECT . . .” The report
has been divided into two smaller presentations and are being
published elsewhere.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

w
arr:

.

:-

'x‘rgy-g-jbgwwfrvgew

',-_'-

'.
"u"

MW

�</text>
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                    <text>July

25 , 1969

Acting Secretary, Board of Medical Ebcminers
The University of the State of New York
The State Education Department
800 North Pearl Street
Albany, New York 1220a

Dear 1r. Wright:

writing on behalf of Dr. J iri Roubicek who is applying
to the Board of Medical miners for medical lioensure by

I

am

mdorsement.

I first became acquainted with Dr. Roubioek's work 1:11er
the literature, for he has been a major contributor in the fields
of clinical psydxiatry, psychophammology and electroencephalography
for more than twanty years.
of the Gmimen of this Department
at the suggestion
M.
Freednm, I visited Dr. Roubicek's
of Psychiatry, 11". Alfred
laboratory in Prague. I was impressed that the work that he and
his associates were doing was excellent and was pleased, on my
It
return, to support a recoumendatim as visitirg professor.
two
In 1968,

was our expectation

that he would join us for

begixming in October 1968.

one

or

years

joined us in November 1968 and since then he has been
closely associated with the programs of the Division of Biological
Psychiatry. I have found him to be an experienced scientist and
He

a reliable, co—oPerative and charming co—worker.
Because of the events in Czechoslovakia, Dr. Rmbicek is
seeking to remain in the U.S. I believe that he is a capable
md well trained psychiatrist and would support his request
for lioensure by endorsement.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>.5,

Christy Wright
Amer. Jour. Psychiatry
Ms.

June 6, 1977

Washington, D.C.
Dear Ms. Wright,

Please excuse the delay in getting this text back to
citation for the Pribram article was hard to get. I
have indicated the correct citations in the margins in a number of
instances and ask that you correct the text in the proper form.

you; but the

title, Myths of 'Shock'
Therapy rather than Electroconvulsive therapy in the title, since
the term 'shock therapy' is one of the myths that I discuss.
I would like to use the improper

Thank you

I believe I have answered
for your help.

all

your other questions.

Sincerely yours,
Max

Finkk M.D.

Professor of Psychiatry

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                    <text>4

January 9, 1978
The American Journal of Psychiatry
1700 Eighteenth Street, H.H.
Washington, D. C. 20009

Boar Miss wright:

enclose the original corrected manuscript and a new procia and
seasons-sheet. we have acecptad your corrections and mad. the
nocnasary modifications in the text and table.

W6

Thank you

for your hnlp.

Sincerely,
Max

Fink. u.

Mrtbc

Encl.

D.

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                    <text>April

8 , 195%

Mrs. Edith M. Wright

Clinical Associam

Mica]. Services Department,

Smith Kline

S

hunch Laboratories

1500 Spring Garden

Street

Philadelphia 1, Fenmylvania

W m. Wright:
Thar»: you

very

much

for the list of mfemnces and the

literature on the effect of 'momzina'
in cases of mmsim. I have fmnm the review emd
especially a few of the articles halpful.
review of the

Sincerely yours ,
Max

Fink,

Dimctor

MF/jb

PM).

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                    <text>April a. 196k

m»; John

Kims

Hmtm,

Texas

Wright

Houstm State Psychiatric

mum

Dear John:
My

madam

and

I had a pleasant day with Dr.

Z. Tamka.

Weapentﬂu'emﬁngatmyhm,mﬂmnﬂmmxtdaym
had
when
an opportunity to
mama,
discuss mt mlymrmnwwk,butyoxmobsewaﬂms in

visited the

we

the prism pqxﬂntim.

_

".10..-.”

Wymforaendinghimtow. Ihopewewemofsme

help.
“5.1-...“

'
V

"m.

Sincerely yours,

VI-‘nwmwa-W,

g'

ﬂax Fink, H. D.

'06?”

.

mmctor

“up...

mpg—”urn“.

fawn-w.“

MF/jb

�</text>
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l,

l968

Dr. Leon Wurmser, Director

Psychiatric Outpatient Department

Sinai Hospital of Baltimore, Inc.
Belvedere Avenue

at Greenspring

Baltimore, Maryland 212l5
Dear Dr. Wormser:

Enclosed is a copy of our report which has Just been
accepted for publication.
I

trust it is helpful.
Sincerely yours,
Max

Fink, M.D.

Proféssor of Psychiatry

Mszp

�</text>
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                    <text>May

1, 1968

Dr. Leon Hurmser. Director

Psychiatric Outpatient Department
Sinai Hospital of Baitimore. Inc.

Be1vedere Avenue at Greenspring
Ba1timore. Maryiand 21215
Dear Dr. Hurmser:
Enc1osod

is

a copy of our

accepted for publication.
I

trust

it

report

which has

just

is heipfu1.
Sincere1y yours.

Fink, M.D.
Profcssor of Psychiatry

Max

MF:kp

been

�</text>
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                    <text>December 19, 1984
w

......r

m‘,lwr—v~

«so;

&lt;1

.-

Judy Wurtman, Ph.D.
E25-604

Massachusetts Institute of Technology
Cambridge. MA 02139
Dear Judy,

y——.-.,War-—-uw_v-—'-u

n-

It was a pleasure having dimer with you and Dick in San Juan last week.
The tan is fading rapidly, and despite my best efforts to tell my co-workers that it
came from sitting too close to the slide projectors, they are not persuaded.

.

A reprint from our experience with fenfluramine is enclosed. The work
was initially done at the Missouri Institute of Psychiatry in 1964-65, and replicated
in 1965—66. 1 hesitated publishing it, until we had some clinical experience (open
trials in obese subjects seeking a weight reduction regime) and had confirmed the
compound's sedative qualities.

it was this study that convinced us that the pharmaco—EEG model had
merit in man, yielding information that was independent of animal trials, more
relevant and reliable with regard to clinical projections and experience. It is this
model that has been so useful in defining the clinical profiles of doxepin, mianserin,
flutroline, and some antihistaminics, antihypertensives, and hormonal agents with
greater accuracy and reliability than the animal pharmacology.
This model is well accepted in EurOpe, where many of the large
pharmaceutical companies have 'in-house' pharmaco-EEG laboratories; and where
numerous 'contract-laboratories' do the work for the smaller firms. The Europeans
have founded an "International Pharmaco-EEG Group" which now holds biennial
meetings (similar to the CINP). in this country, only Turan ltil at the New York
Medical College and I are active researchers in this field. If you are interested in
obtaining a more accurate appraisal of enantiomers or congeners of fenfluramine,
the pharmaco-EEG model can yield useful projections as to a compound's CNS
activity, its classification, dose-response range, and behavioral effects.
My

I also enclose some more recent summaries of work from my laboratory.
best regards.

Sincerely yours,

Professor of Psychiatry

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                    <text>”‘0

January 2n, 196u

Dr. Jahn P. Hyatt
Professor of Pathology
St. Louis University school
of Medicine
1H02 South Grand

St. Louis, Missouri
Dear Dr. Hyatt:
.

search

Dr. Janna S. Nelson‘has applied

staff of this Institute.

1957~1959. 1960-1961.

He was

for a positian

on the reassociatnd with you frum

This Institute is the research center of tha Diviaicn of
Mental Diseases of the State of Missouri and is dedicated to
studies of the sevaxu mentally

ill.

I

'

gratefhl ferryour opinion regarding Dr. Nelson's
undertake
independent research. his ability to gut alcng
capacity to
with his coawczknra. and any suggestions regarding,his intarests in
teaching. ans of the aspects of’the program of this Institute is
in tha training of psyehiatric residents. and'wu ara pleased to cansidar Dr. Nelson as part of tho faculty.
would be

Thank you faw*ycuricocperation.

Sincerely yours,
Max

Fink,

tﬂxectur

Pfkmlg

M.

D,

a?

1

“ﬂ,”

‘Mi

“1

($_ﬁ‘""wﬂx

�</text>
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                    <text>-m mr—vmv.W

mwl"-IWW—nw—m

July 22,

1970

Xerax Corporation
295 Madison
New York, New York

Attention:
Dear

Mr.

Saratella

Sir:

Please make six cepies in reduces 3 1/2 xrll of our
records marked ”onepin 0ra1 Study”. Please collate.
Please

bill

me

at the

above address.

Sincerely yours,
“4.3.x

Fink

’

:1. r)

0

Professor of Psychiatry

HF:kt

wwwl‘qw—‘W

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                    <text>7433~06083
24

January

1974

Hard Pigmen. Ph.D.
Chairman, Tenure Committee
New York Hedicel College

Graeolsnds Hospital

Valhalla,

New

York 10595

Dear Dr. Pigeon:

I an writing in support of the appointment of Torso

M.D.. es Professor

Medical College.

in the Department of Psychiatry of

M.

New

Itil,

York

I have known Dr. ltil since 1958, when our common interest
in the EEG effects of psychotropic drugs brought us together
at an international meeting in Rome. I wen instrumental in
bringing him to the United States in 1963 at his recent position at the Missouri Institute of Psychiatry.
He is an outstanding research scientist who has worked with
enthusiasm and order in developing the whole field of quantita»
tive electroencephalography and its applications to clinical peychietry. In the many years that we worked together, I found bin
enthusiastic and innovative. He is a delightful person to know
and has friends all over the world.
New

I an pleased to recon-end his appointment as Profeeeor at
I so confident that his contributions

York Medical College, and

to the Department of Psychiatry will be significant.
Sincerely yours.

Pink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>21 March 1974

H E H

0

R A H D U H

To:

Arik Briaaandan, H.D.

From:

Max

Fink, H.D.

sabjact: Additional Funds (FY-74, 6th Qtr.),
LAAH vs. Hethadane Cooparativu Study
Additional funds in the amount of $6, 3&amp;0 have been

made

availabla for the tasting of brain changes of patients raceiving
levnlathadyl and mathadaac.

We have requested an EEG machine from General
Hospital
Equiplnnt, and these additional feuds should be used for the
following items:

1

Hewlettérackard tapa recordar, FE,
A-channnl, Model 39603, plus rack
mmt...‘.t..l.....DO...U..OOOOOOOO'OOI$‘585.00

l

Oscillator, Eewlett~Packard,

1

Oscilloscopa, Kawlett—Packard,
dual beam, Model léOB plus time

frequency range, Mbdal

m We].

low

20262..........

375.00

I‘GSA.0.0.0....IOOQIIOCCOOQ 1250.00

$6010.00

In addition, we will raquire the balance of the funds to be
used to purchase some small piecea, such as a tape degausaer,
couch, table, etc., which may be required in ordar to establish
a fully functional laboratory. A raquaat for these items will
follow, pending the purchase and receipt of the principal itaas.
HF/cis

�</text>
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                    <text>Octobar 15, 1963

Mr. R. L. Yeager

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                    <text>December 12. 1968
Yellow Springs Instrument Company
Yellow Springs.
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record them as rapidly as possible. We
are equipped with a Grass Model VII polygraph.
May I request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele-

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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1968

Yellow Springs Instrument Company
Yellow Springs,
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record than as rapidly as possible. we
are equipped with a Grass Model VII polygraph.

request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele~
May I

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>a

T-l Mbdification ~ 01
Rovembor 28th, 1972
mo:

8. Yollea,

FROM:

M.

SUBJECT:

Preliminary Space Allocationu, Research Tower.
Floor T—l - "Psychiatry”

Fink,

M.D.

M.D.

floor consists of a aorvioe core, and four quadrants.
architect's guidelines, the SW quadrant oontains
offices for the chairman, conference rooms, secretaries services,
etc;
The Twl

Following the

The remaining quadrants were designed

Quadrant

hospital.

ﬁE

oontains tho passage for connection to the

As on initial
reeommended:
SW:
KW:

HE:

SE3

for chemistry.

step. the following general assignmonts are

Chairman, Conference, Lecture rooms, Clinical
Psychology
Neurophysiology, Biological psychiatry

Biochemistry, physiology

Library, neuroysychology, payehophyaiology

Should those designations be acceptdble, many rooms require
modification. At this time, deletions of permanent installed
equiyment are recommonaid for the following rooma:
8W:

557 ~

A

598~A

599 ~ A
A
597

-

7h2-A

A

A

s

'
«w'v

v?
v
:rw

~mWIIW.u-w7m'xmwmnw

jww

NV:

558

-

A

7&amp;3

-

B

600.1:
601 - A

�J“.
.4

B.

Yollen,

«2-

M.D.

603
167

HE:

'172

-

Hovember

28th, 1972

A
C

~ A

SE: 606 ~ A

560 *
559 857 ~
827 -

A
A

A
A

Th5 ~ 3
A.

Deleta central bench, hood, wall bench. Leave wall cabinets
only if general purpeae stcrage. Leave 110 v. outlets,
minlmum 2 each, h walls. Leave l HCW sink in appropriate
corner.
’

cold room. leave shielaing. wall bench and
Delete DI, ather benchea.

B. For
C.

Delete

all central

all fixtures

F15, 203‘
.

MF/iJ

on one

Remaining rooms

HOW

sink.

benches, wall benches, except bench ﬁith
wall, preferably the unit éesignated

to remain

an planned.

�</text>
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                    <text>June 29, 1967

m. Stanley Yollee, Director
National Institutes of Mental Health
»

Bethesda, Maryland

7

-

Dear 'Dr. Yolles:

report this morning of "A drug more
special interest to me because the data
potent
the piperidyl»
likely that 3?? is one ofJE—BSE.’
presented Was it very
Wee
JB~318
JB—329
or
(Ditran),
benziletes, probably
been
have
and
decade
thm
a
s have been studied for mm
New York Time
than LSD" was of

The

'

in Milwaukee.
'Ihe principal reason for omcludmg that these compounds
the subjects
may be of this class is the clinical description that confusion
excitement,
mania?
experieme a state characterized by
and hallucimtions , misting for days; and that they exhibit
and blurred vision. The
dilated pupils, rapid pulse, dryNewmouth
Times is the exaggeration
York
most witical stetenent in the
of the; psychotic state by ohlozvmzine.
In studies both at Hillside lbspitel and at the Miami
in the Em
Institute of Psychiatry, I have been interested
some years ,
For
.
effects of a. wide Variety of hallucimggens
when
the
my associates and I have jokingly indicated that
foumi
would
be
to
giperidybbenzilatee hit the streets, they

produced by Lakeside Laboratories
.

‘

be mob

more"

potent and

much
The.

LSD, EMT and

differences between the antiand the smethmnﬂmtios are clearly
the liberty
defined by EEG and behavioral criteria. I am taking
1967 from
196C:
and
one
of enclosing; two mports - one from
studies.
vmioh describe the essential parts of these

other smatmmimtics.
'cholinergic halluoixwgene
-

more dangerous than

For practical pxmpoeee, the most important fact is that
(TEA) is a very
an experilmntal conmound, tendiydmamimcrin
the clinical symptoms induced by
potent nntegmiet modifying
90%
of the psychotwimticeractivity.
these companies to 80 ~
studies frm the Lakeside
is available for experimental
M
Laboratories, and I have a supply which has been available to
me mder an IND filed about two years ago.

.

Linn;-

3:“

‘

ﬁ.~.«:.o.-.~:;_;

easnzxeeezaly

�i
mzw‘rfu‘m‘

;rmw.¢~wqm‘

Dr. Yolles

June 29, 1967

«2—

-

7.“.

alerted our staff to the possibility that patients
with
in
acute psyclntic episodes exogenously produced
my com
md will try to modify these states by TEA. Perhaps , if a
supply of 31'? could be made available to us we muld try “to
find volunteers and detarmina specifically whether 31‘? is of
the am class as the piperidyl-benzilates and if , indeed, the
We

&lt;

»
,
-

yum-rm‘am-IWWM;

~
A.

u

have

psychotic state

is mapmaive to

TEA.

Incidentally these studies have been supported largely by
the psychophamaeology Study Cmter of HIM?! under a variety of
study grunts.

Sincemly yours ,
Fink, 24.1).
Professor of Psychiatry

Max

MF:kp
~

.5,

v‘.-:“g.g"j‘-

,
.‘

‘waﬂr

-..u1z:.

shaman-or

74:1-mnnm.ﬂw/

w
a.

.

M.

.,

w

-,
_

v

ll“.

i
mm);

A'Liistﬂt'kiihn'ﬁdr«

u—A

ura-

paw-xmmrvsv

:w

V

�</text>
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                    <text>June 17. 1968
Dr. Stanley P. Yolles

Executive Director

National Institutes of Health
5454 Wisconsin
Chevy Chase. Maryland

Dear Dr. Yolles:

I want to

talks. both in

tell

New

you how much I enjoyed the

York and Washington.

I discussed with you. I am enclosing a
copy of the present marijuana procurement procedures
as sent to me by Dr. John A. Scigliano. While we
will attempt to comply with these requirements. I
think it would be useful to make the procedures
lees onerous. Surely. marijuana and THC cannot
be so dengerous that the procedures should be
significantly different than the testing of
investigational drugs.
As

assistance you can give to make marijuana
institution
or THC available for stucy at this(EEG
MH-13358
and Human
under our present grant
Any

Psychopharmacology)

will

be appreciated.

Sincerely yours.
Max

Fink.

14.1).

Professor of Psychiatry

Hakp

�</text>
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                    <text>November

Dr. Stanley Yolles
Uirector
Rational Institute of Mental Health

5454 Wisconsin
Chevy Chase, Maryland

Dear Dr. Yolles:

writing to ask your assistance in legally making
available supplies of marijuana for experimental research.
I am

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invited to a meeting at the national
Institute of mental Health at which studies of marijuana and
cannabinols were discussed. Following that meeting I obtained
the necessary certificates, filed various forms, protocols
In May, l967 I was

applications to hlhh, appealed to the Federal Bureau of
Narcotics and attempted to obtain supplies of marijuana through
legal channels.

and

Through the cooperation of ﬁrs. Efron and Levine of the
Psychooharmacology Research Branch. 50 ampules of THC, 10 mg
each. were made available this summer. Since an essential question
to be answered was the comparison of the effects of marijuana and
this THC product. I deferred the studies of THC. awaiting a response
from the appropriate committees at NIH. I answered the requests of
Dr. Scigiliano and filed the appropriate forms. In late August I
received a detailed inquiry from his committee. which I immediately
answered. I have not heard from that connnttee since August 23.
I deferred undertaking the studies of THC, hoping that the Committees
in Washington would respond in some direct fashion - either denying
my request, or providing me with some answer which was reasonable.
I have not heard from them and on frequent occasions I have called
and received no reply.

Recently,

to requests from your
Dr. Freedman whether our programs were under
way. At Dr. Freedman's urging, we began our studies of tetrahydrocannibanol on November l. Unfortunately, the supply of
THC is severely limited, since six of the
fifty ampules arrived
in a damaged condition, leaving us with 440 mg as our total supply.
Mr. Kavanaugh. responding

office. inquired of

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November 12, l968

«.3

for

Having no response from the Committee
some months, I would be grateful for a

from your

office or that

Committee.

or Dr. Scigiliano
forthright reply

In the event that supplies of marijuana for research are
not available from the National Institutes of Mental Health
(and having been told by the Federal Bureau of Narcotics that
Health that
it is only through the National Institute of Mental
legal supplies can be obtained) can you advise me as to an
alternate route, within the law, that would allow us to continue
this research program?
am

So far, I have hesitated to write to your office, but
encouraged to do so by your assurances in June and your

recent assurance to Professor Freedman that we may turn to
situation no longer appears tenable.

you when the

Thank you.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
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                    <text>November

ll,

1968

Br. Stanley Yolles

Director

National Institutes of Mental health
5454 Wisconsin
Chevy Chase, Maryland
hour Stan,

Separately, I have written regarding the difficulty
have had in obtaining supplies of marijuana through legal
channels for research purposes. The climate which encourages
this complex bureaucratic limitation of studies in this
important public health prohlom encourages no to write
regarding an important associated problem.

we

During the past two days Dr. Paul Kielholz has lectured
New York Medical College on the subjects of narcotic
the
at
addiction and the treatment of depression. In the course of
our conversations. he shared with us recent roconnnnoations
of the special committee of the World health Organization,
of which he is a member.
-

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k‘g?’xlllf‘;'"ld"v‘9

The

Conmittoe's formulation, as distributed by him,

is attached. indicates that cannabis has
application and that it is to be classed among

a copy of which

no medical

the habituating compounds.

inquired the evidence upon which these two decisions
Dr.
Kielholz referred me to the well known literature
based.
were
of the past centuries. He made it clear that the Committee had
acted without additional significant evidence - surely, none
that he could refer no to in the scientific literature.
When I

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Considering the difficulties which already enshroud research
in marijuana and the cannabinols. such a pronouncement, especially
if accepted by the United States representatives. would ensure a
most difficult future for research.

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Dr. Yolles

November

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ll,

1968

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I am taking the liberty of bringing this to your attention,
in the hope that you can refer this information to the appropriate
committees of your organization, and perhaps the leading psychiatric
associations of our nation, so that this proﬁlem can be avoided.
I am sufficiently discouraged, to send copies of this letter to
the appropriate agencies myself, realizing. however, that such
a communication without the political support of offices such as
yours. will have little impact.

Thank you for any actions which may assist in relieving
this potentially serious interference with research in an

important public health problem.
My

best personal regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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                    <text>Docember 17, 1971

Dr. Stanley Yolleo
Chairman and Professor

Department of Psychiatry
Stony Brook
Stony Brook, new York
SUNY

—

Dear Stan;
who

writing at the request of Joseph S.
is applying for appointment to the Department.
I

am

A.

Miller,

H.D.

Joe was the Hedical Director during my years at Hillsido
Hospital. He was a fine clinician and his conferences were well run.
he was most supportive of my research efforts. encouraging the Board
of Directors, and the Research Committee to approve the projects.
havo only seen him on fan occasiono since we both left
Hillside, so am less acquainted with the work of the past decade.
I am pleased to recommend him for a clinical appointment, knowing
it would be interesting to work with him.

I

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Whig

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Match 11, 1972

Stanley Yollen, M.D.
Professor &amp; Chairman
Department of Psychiatry
SUR23§tony Brook

Stony Brook,

New

York

Dear Stan,

It gives me great pleasure to recommend the appointment
of Khan Dotnbush, Ph.D. to the Department. I have known her for almost
four years, and during this time she has made extensive and valuable
contributions to my studies of ECT and cannabis. She is particularly
involved with cannabis research at the present time.
She has chm

record and the experience to be considered

for the academic rank of Antaciate Profeencr.

Initially, funds for her appointment will be available
anticipated grants, particularly the transfer of ME 13358,
my EEG study program. I would anticipate, that should her
appointment be approved, that she will establsih her own study pro~
gram in cannabis research, and I would be pleased to assist her
applications.

from the
which is

In addition to her appointmant to the Department of
Psychiatry, I believe she could make a valuabla contribution to the
work of the Department of Psychology, and would suggest that she be
considered for a concurrent appointment in that Department.
Many

.—

:‘r

thanks.
Sincerely yours,

.,mt'.t‘,aor-Man,.-,u"-r

r
«

tn,

-—.m-

Fink, M.D.
Professor of Psychiatry

Max
...

mf/

�</text>
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                    <text>Ref: 72-323

SB

June 27, 1972

Stanley Yollea, M.D.
Department of Psychiatry
SEXY-Stony Brook

Stony Brook,

New

York

11760

Dear Stan,

In checking the events at Montrose V.A.

this winter, I find
and that this
appointment was approved in Washington. Enclosed is a copy of that
application. Dr. Harris at Montrose has the file and can write the
that they did appoint

appropriate

I

me

a Consultant

in Psychiatry,

letter.

Perhaps this will make

have sent the same to Dr. Derman

methadyl study.

I shall be at Raquette

my

appointment to Northport easier.

at the Manhattan

on August 1 and

for the

lava—

for July. Should the
office in New York;
York. I expect to
will call your office that week.
Lake, N.Y.

occasion arise, you can reach me by calling
or writing to Genereal Delivery, Long Lake,

return

V.A.

my
New

Finally, the Greek cannabis study will be funded; the
Jamaica was sunk by lack of State Department clearance; and Jerry
Levine has yet to answer me-- I will call him at the end of this week
again.

Hy

best to all.
Sincerely yours,
Max

Fink, M.D.

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                    <text>I

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                    <text>r»

Hovambar

Stanley F. Yolles,
Max

27th, 1972

M.D.

F1nk,M.D.

Hotel to Modifications.

Psychiatry

3123.62

Second

Floor,

V. A.

Hospital

The unit is designed for carrelated studies in behavioral
(pnynhia$ric) analysis, psyehophyniology, EEG and eamputer

cerrelations, and biachnniatry; for studies of patients and
volunteers.’ Animal studies gr. plaansd for the medical~
surgical animal cantor (36).

l.

Laboratories deaignatod an EEG, paynhophyeiology,
Phyniology are $0 be eenﬁrally air canditionad; and each to
have sink, hot and acid water. air source.
2. Comyuter faaility
cooled air conditioning.

to have the usual separate water

3. Cdilinga in laboratories to be lowered ("doublenhung")
with removable tile: to allow cabling from laboratories to

computer

unit.

h.

Laboratoriea noted‘with (SP) to have no windows;
separate air handling; and special sound reduction insulation.
5. Bioahemiutry laboratories to have the usual air/gas/
hot and cold water/special want: and vacuum lines.
Three rooms to hava one way absarvution windows;
appropriate dark shades far natural vindoou; available fbr
observation, either airection in group dbservation room.
6.

7. Classroom to hawe curtains that can aarken roam;
scream (aukomntic, electrical) and special. projection cabinet
far 2 x 2. 3% x Mk and 16 mm. sauna.
(a)
-

(In)

8. Hbrknhop, computar, physiology laboratories to have:
110 volt outlets 30 amp. soparate line each roam to central
main panel.
Computer to have 220 volt 100 amp, no volt. 100 amp lines

for computer and air eonditioning.
(c) Fluoreaeent lights in laboratories to be shielded.

MF/id

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                    <text>;_”

11/6/72
Stanley

rm.

see

«Mum

131.1).

W

of

was in

Mail
mm.“
W1. naming

5:

i
.

for their

night be

ml

,
~
3

24.13.

mum-ch by the new Foundation
interest“ me. I helium: that studies a!
fit the goals of this
maﬁa
foundation. Rather than my
on this abject,
that they consider
or that may maxim reviewing this prom

i

f“

Max

TM attached

3

_

101193.

10'.

“tum
1.1.

was, wimp: a letter from you

use mam.

�</text>
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                  <elementText elementTextId="106520">
                    <text>«mlwnrm

r. rr'

r;

..

~-;.~

own...”

=1W --

7...,

LufaﬂVéh"

042'

,.:‘v—O’uw.~uv.1...)1mW

7:.."1‘J‘W9-“L‘ﬁz'cﬁ'syuox'A‘:'n.ny')v}jr«lqv-yuvw7

Irv—“w.uh”

my:

7.11:»-

Var WM,

n

.v-v

w

u

y...“

., _.
.

r,

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-

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,u

m, , Y

~.- ,

.._

l 7,.

..

v

w

,w;

.

|
4

mambo

.
.

ﬂaptenbcr 28th, 1972
To:

Btonlqyllollol,

.

,Chairnan,
FROM:_

.

.nax Fink,

M.D.
Doporﬁmont

of Psychiatry

M.D‘

Isunamcwz' Laborotories :05 T91, Bow school Building

I have roviawod the druvinga for T~l, and nascent that
teaching goo research laboratories ho dotined and soon opoeisl
rhesus»; ho inoorporatod in tho building as it is oomplotod.

.4

u

,

anv.-zu,x..

r.

.Iy-

H

1. ';$~;ﬂyﬁrsiol*$*
Boeinalns with the note that 877 is set aside as an
informstlon retriovol facility, I would suggest Laboratory
560 be unsigned to tho Eﬁo~oonputor, and rooms 800, Th5, and
hos be planned as ahiolded rooms for polygraphio recording.
should you wish udditlonol laboratories, hos and he? can be 9%
designaood laboratories. what: proximity to the computer
for processing may be advnntasoouo.

If such a douignotion is Etna, than the following
supporting units eon be assigned:
Data Processing
Shop ~ #357

-

#6053

'

Storage. Equipment Luborutory - #606
Qrfiooa - I507, 508. 319, 373, 519, 827
2. szghgotrio Dita Prooosslga

statistioal work of the Dopartmont.
for
keypunoh. calculation, files,
laboratory
dots processing terminals. Perhops 607 should be doaignnted
for this use.
For data annlysin oud

you V111 wish a

*3-

aim

Rooms

87?, 86?, 887 raunin as designated.

�A faa1lity tbr obsarvat1on 1nd recording (both audio
aaa visual 'TV') would be useful Suggc-st 121,be single
interviewing ream; 221_a group (largo) 1ntarviev1ng roam; and
33g.aa the observer—reearding roam. Thia V111 requ1re cable
canneations and windows from Th2~557~797.

Rooms S97~598¢S99

ltbérator1es.

should be designated "psyehology"

Rooms 559, 799, 722,167 (7 603, 691) could be cqnippad
as 1aborutar1es w1thhanchas, gas, H.902, etc. If so, #151
(172
200m 1132) and 897 012 he daiignated glassware, instrumont,
15nd storage raamsy

in

6

to be daleted
thaue laboratories meet our ant1¢1yatea needs, then

’Laboratori 3

It
the 1:222mmory
designation for 597, 598. 599. 600, 601 602.
553 uhn21d be aeletoa. and 1aberute21es 560. 607, 557, 605, 606
22 re-dos1gnuted :3 outlined above.
shanid these augaastians be agreeable. I Will out11ne
the specinl requiremanta for the rooms designated._
22/13

7

�</text>
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rdbrunry 6th, 1973

stanley ?. Yollou.

To:
‘

_

mom;

‘

SW:

Lax Fink;

3th.?! of

M.D.

aw.

13mm

of Pmmumy mm

In scanning the tararnal “Stuff of Department of
Psychiatry" 113%, I have two suggestionu.

"5‘

.

Dr; Alexandcr_non:

erzvz‘n'wAW-w‘

He

has not been recommsndéd

far Aniaainte Protuucor. sad I vauld sugscst that

run-MW

cum?“

\

pu—

'xnvrm'mrw-ﬂ

ha be

listed under the technical title or Staff

Plvﬁhiatrist. Y.A., or_ConsuItant to the V.A.
Dr. Jan Vbluwkn: -A1though I htve asked you to.
consider his appninguant. it is inappropriate
to lint ht: until he hap_&amp;ne1ded ta allav me $0
procets his payers; I suggent he not be listed as
he is still ”making 33 his mind“.
'

13-"vm:w,

n

ﬂ?/13

WWW'IFWI'WnleivmWWIWWT'm'W

‘5

.

‘

�</text>
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                    <text>7333.592
Herch 26th. 1973

ma

PM,

HID.

g

Cheirmnn, T.A.P. Comeittee,
New York Medical College.
Greenland: Hospital Genpue.

Valhalla.

N.Y.

RE: Dr

Durﬂb

Deer Doctor Fianna,

I take greet pleeeure in reacunending the promotion or
Dr. Rhee Dorebueh from her present poeitioa, Anni-tent
Professor, #0 Aeloeiete Professor, in the Department of
Peyehieﬁry.
Dr. Dornhueh has worked'vith we fbr
years. During this time I heve antten to
es e researcher end en e teeeher.
As

more than
know

her

five

ability

e teacher, the he: tenant cleeees in the reeideney

treinina progren. in experimental peyehology, epplieetion
of eteiietice to peyehietry, end seeeione in neurophereeeology.
I have exvuye been pleased ta cell on her end heve fauna thet
she in well prepared enn well liked by the students.

In her research ehe has made significant contributions
in underetending ot’meeery function as eltered by electroconruleive therepy (30?). About three yeere ego Dr. Freeémen

end

I

asked her $0 help an with our etudiee of eenndbie. Eur

oontributionein this work have been significant end the is
the principal inventieetor in her etudy program.

new

She is qnelified for the rank at Asunciete Professor‘by
her training, experienee. yublieetiane, teaching dbility end
experience, and releerch leaderehip. I heartily reeamnend
her fer proactien at this time.

Sineerely yours,

ﬁnk. MID.
m
Proteeeor of Psychiatry

“Ilia

�</text>
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                    <text>738B~6h2

Dr. E. H. Terry.
Pharna Research Canada.
250 Hymns Boulevard.

Ltd..

Potato Claire 730.

Fqu .
Dear

Mt

Skitch,

It

was a pleasure

talking to

ynu yectcrduy.

In 1971. and again in January of this ynar,
was asked by the Directer of Beaaareh at another
Enropoan company to put-my thoughts an the needs
psychaphnrlncalosy on paper. I did so, and the

I
or

enclosed notes reflect my thtpking o! a ten’months
use. In rouregding this, I would mats so few amend~
manta that tha text is easenticlly my present Opinion.

I trust this in useful.
aincorQly yours,

Fink, 3.9.
Professor of Payuhiatry
Mun

Hr/id
Rue.

�</text>
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                    <text>w.~&lt;v

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April 26, 1973
Dr.

a.

C.

Lairy,

Hopital ﬁanri Boungella.
1, run cabanis,

75-min 1”.

France.

Din: Banter nniry.
Enclosed

1n Mhrncillo.

is

my

ragiatrntian far the fartheoaing matting

I submitted un ubstrsnt to Profeutcur
J. Cudilhac. unﬁicipn$1ng tn axhibit. A: the onclnued
latter indicakos, I have had to «hangs my plans becnusc tho
exhibit in no longer tangible. I vuuld be grateful if you
aan still coaaidor thin dbstrnct for ; yrescntszion in
Btytuubar; I rcccgnizc that tbs deadline data at April 5th
has already passed. but I trust an cxneptioa can be mada
sinao this dbntract was actually submitted many months ago.
Same month: can

Truating to your 59nd officcn,

I remain,
Sincerely youra.

”at. ”CD.
m
Prnfccuar or Psyahintry
33/14
Eha.

,

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                    <text>m...

War:

a:

.--.;...As.,;:»

g.e-

Trim-63h

Hodical Lieansing Basra.
atate a: New York.
Twin Tavuru. 18th Flaor.
99 Wishinsten Avenuc,

Albany. R.Y. 12210.

Re:

E.

Pitts

M

B.

Gantluncn.
am Flttlcd to vrita on.bchalt at Dr. Bbrman Fitta.
I hurt known since 1967 in his many roles of increasing
responsibility in ¢liniea1 research at Pfizer. Inc. As a
consultant, I huvn had many opportunitiou to meet vith
him, to unseat nadiaul studios and cat: with him. and
becaun aaqnainted with his knovledgo of clinical madicino.

when

I

Dr.

Pitt. is

an outstanding

cliniciin, with a

keen

interest in and aunrcnall of the yrohlqns of patient
care. dingnosis and trontnnnt. Ra in warm. friendly, and
congenial in his interpersonal relations. and ralidbla
and thn'ghtful in axercisins his professional responsibility.
In I? relntiunlhipu with him, I 3&amp;3 reflect on no oxpcrionao
or quality of personality that would limit hi: full
endorscmnnt fbr licensurc in medicine.

I an pleiscd to undorle his applicatian without
reservation.

v-

Singeroly yourt,

aﬂ.7=:l__";"

'5
.2=),v,:

Jan

mm...”

Fink, M.D.
?rofnsaor or Ptychigtry
Mb:

MF/id

�</text>
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zvc-rmn

«:1

‘

.«

7353-635

April 23. 1973

Yell...

To:

Stanley F.

13014:

”M Fink, ”6D.

SUBJECT:

Hbdifion&amp;1on

M.D.

er Esau

2312

Enelosod 1: a drawing prepared

at our ruqnast by

his couwartarl at the rhoilities Plnnning
modification of room 2812 an three
the
affine. In:
simple ldboratory apaeea far phyniologieal recarding.
R. During and

principal elqmentn are walla. modification
of ‘1r handling. lighting (which is incandescent rather
thin fluﬁraacent), and a change of electrical wiring,
such that each roam is on ; separate eiruuit breakur.
The aatinnﬁc is $1.500, and from my past experience
should be quito aeeurate.
The

Please advise us to any further si§?a.

ur/13
Baa.

�</text>
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                    <text>\V

-'

w‘rv-«mwm

a
17

«Qua-"m

W‘dw—"ﬂ

73SB—616

April 9th, 1973
To:

Stanley P. 1911‘s,

FRUM:

M31

SUBJECT:

Lester Shapire,

Fink,

M.D.

M.D.
M.D.

pleased to reeoumend Lester Shapiro, M.D.
fbr promotion to Associate Clinieal Professor in the
Department of Psychiatry.

I

am

Lester since 195h. At that time I
eetive in the Nassau Heurapuyehietric Society,
the district branch of the APA. Lester was one o! the
principal leaders in that organination, end it was
largely through his efforts end encouragement that I
assumed an active role, leading eventually to the
Presiaency in 1959. Throughout that period or time,
and subsequently, I found Lester's advice to be logieel.

I have

became

reasonable,

known

and

his

Judgment

excellent.

Subsequently he took an active interest in the
In the county he has always ahnwn an
interest in the training program: for General Practitioners.
I have known him es e preetitioner, to whom I have
referred eases, and Iran when I have received enquiries.
In such clinical eitﬂetienu his Judgment we: excellent
and his point or View eeleetie.

APA

itself.

During the pest six months I have had numerous
oeenaions to discus: our training program with him.
Again, his eeleetie liev end good judgment has been

repeetealy aennnstreted.
In

I believe him to be a fine elinieien sad teecher.
mind he satiet1el all the requirements or en

my

Antoniaxe Clinieel Proteeeor.
MFI13

�</text>
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                    <text>ESE-$86
Much 27th. 1973

mu»,

we:

Manley F.

FROM:

Ma

mm:

Window: Coutmt

Fm,

24.».

14.13.

handing the roply whieh in mm for:
3.. Ho ”upon".
2. All the mad: at m nm are and for
rumination. Aw mum}: activity is financed

and
tram
by

Univunity funds.

3. no momma.
1;.

(a) For 1973-73. in have

«may to member;
has 105-4105 capacity. Our

at

891

capacity. [Capacity ..

1205

man

utilised the

beds of

me

and now
{mam-hm;
pmjmuon for April-Jam is

1005

21

m].

For 191'3-73 we are projccting 219-30 bod:
aver capacity being housed in mm man.

- the

staff visits: Putin“ visiting staff as
Mystique: ammc BS-BO/vnk at this time, increasing to
80-100 by June. For HTS-7%. we: anticipate 100—150 cm
visits/wok.
(b)

(a) Contrmt

am:
am.

visitu

to Dr. 8. Kieth:-

new in date. and none projected.

�</text>
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"hazwm'ﬁ-lvf?

/
n

.

HEB-577A?

Lurch 12th. 1913
To:

sunny 1'. You”,

mm

ﬂu: Pink.

mm:

American

$.13.

194.1).

Pswhcpnmmsiul uncut-Men

m

Dr.
ﬂak was eluted President or the Algerian Psychoputhologictl Auceintien at in: annual meeting in March.
Inoculation in in its 5%}: you and has 0. Worship 01'
.250 pmhiatgviats, pmheloguts and kingdom scientists who
met madly ta discuss mutton: or the relation of

m

to behavinr. The 1971: topic: in
evaluation of payeholasictl modiﬁers at behavicr".

psychology and physiology
"An

Dr. Max Fink is Professor at Payehiam 1n the 3mm:
acumen Center and investigator 1:: studies at the mutton
or mmphyaiclogical mum-ea to hehavior, and muzzle
antagonists in the treatment of opiate (immense.

13/13

�</text>
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                    <text>~13

r'wwm'vé‘rw:

7%8—56183

mu 5th, .1973

9'75“”

am

-o.‘1-,:ad'm-

«re

yaw-7‘

'

WWW-'Wﬂiay-

You“.

To:

Stanley P.

W:

m Fink. 24.1).

SUBJECT:

Norton 0.

miller,

Md).

35.1).

—-‘mw»§-w

I an planned ta write in support of the recamendntion
for “mm: for m. marten Miller.
Prior to wining this faculty, I had occasion to work with
Dr. Miller when ho was an administrative leader at the Nation's.
Instant. or maul 3.51%. in mm role I foam! him unusually
tnumgont. innovative, and sensitive to social 153m; of
mental health.

emit:

E

81m. Joining the faculty last
I have worked with
number of comittees.
in the training program and can awar,
On each occasion I he.” bun impressed. by his induatry, enthusiasm,
smdrill. and; his ability to bring ta both the taaching and

him

aspect: of our work, a brand perspective and s
Maintain“
sensitivity.
Wedwith enthusiasm. accepted the challenge of the teaching
He

._

.,

~.

.‘

I

am

pleased to recommend him far consideration for tenure

tin was or the Stat: University or New Yam-y a. I
conﬁne“ mm: In is nrioualy counted to teaching as a
under

and
V

to this mimityc

mm

an

cum,

�</text>
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5

E
-

mu»:

15"."‘nlvai'Pk'

q;

7383-53083

February 15th, 1973
TO:

E

FROM:

.3th

1'.

Gone M.

smith. Mad).

”fall“.

24.1).

m Fink. Md}.

1' have read the
publimum of 132-. 83111211, and his
emiculm vitae;
If. is difficult 301- m to envision an active mew
19
far Dr. 831th at this timu E1: 1mm.“ in opiatan
in their analgesic componmt, and in this ha in

ml?
m
helpful in

a.

docs not have the exparimee which vault! be
programs in treatment. or :1:qu of
eluted opiate angina-nee and multimsubstma abuse. Thu
closest 1: the
or ”Antecedents of toms. drug an"
(WW9). This is an 13:99th magma which my ’0. of

export.

our

mam

am

we: the impression that tho
tannins capable of undertaking
drew
and should we with
1::

inter-at. Homer, I m

university

ml:

surveys.

has

their participation

«Wat's: teaching or mesmh. could we not. get
thair help without Dr. smith!
1m

247/13

m.

�</text>
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                    <text>7:383:72?

Jan. 28,
Mr. Gary Boy-r

Cantor for Studio: of

Hotioul Institute of
5600 Fishers Lon.

Knoxville.

mm

1973

lunatic a Drug
mm Ram: m“

20852

Door Mr. Boyer,

Jam 19 I submitted a. request for 500 Ch
Ila-1.1m. 2.51 no «union for tho withdrawal otudtu in tho
abronio bookish wars in Grace.
8130. than, Dr. Stan Euro. bu
notiﬁed no tho/b the sample: I "quoted worn inadequate for the
on. one hu wounded. that we roam“ 1mm, Equine-dork“!
0::

bookish, 5.5} me in substitution for tho

Enoloud in x mm 2220 form "gunning 300
1. w inﬂation to tmohip than to Profouor you
Storm:for his use, under my current export 11am. P 10100159).

It
Athono

huhtoh.

in

mum.

“my thanks for your ooopontion.
Sincerely roar- ,

Mu Pink, 24.».

Professor of Psychiatry

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                    <text>nan-111
June 19th. 1973
Dr.

0mm

sum“.

Profane: of, Pawn-am.
Univmity or Athenn School a! modicum.
mutton 301911;]...
Av. .
7h,v»1111u13

Athena.- (Ix-«cc.

Wu

6mm;

new

an m
mum.

Inaﬂtuta
1mm by the Human
of 1mm Bum: that they :10
1m. 2.5:! mew-‘9
I m "gunning 11b to be shipped to.” today
and at. the.
that
"quantum a. BBB!) export permit.
1113 my emanation ﬁlm; I would in" most or this
I-

m

mama w1th1n

a

1m

mks sad uhould than be able to
Iphntoshipthcu’aerinlundoryour

two

“lantern;
import 11mm 12km. u I luv: requested 500 grun-

mat many.

emnabit (mum) from the $1.8.
tha Inﬂow Insututo of mm Knuth.

My best regards.
8111mm}: you".

in: ﬂak.

14.1).

Protcuor of Psychiatry
20/13
nun.

v.3. I awn manned. eh“): (1271. awed April 10. 1973.
Eneloué 1: n rmlncmnt for this chock. It you find
the M13111“, plan ants-u}.

�7383-700

Juno 15th, 1973

Costa: Stefanie, $1.1)...
Prof-nor of Psychiatry.
University of Athena school of Medicine.
Egiuition Eoopim.
'

'

’

Th, Vuillissie sophiee Ave...
Athens; Greece.

Denr Cootes ,

I very mach enjoyed our visit and was very much
impressed by the extent and quelity of the work that you

end your

usocieten have

done...

Enclosed is a review of the budgetary allowances,
mount mid to date. end the muse. to the end of
the your. It in peninihle to Water fun!- from one
category to mother except that equipment my not he
bought and that travel expenditwre: my not wooed the
snowmen given.

m

I

have spoken to Dr. Euro about the high concentration
At first. he felt that huhioh should he used.
but after noon discussion we earned that a. high dose
would be eoooptehle. I called Mr. Boyer, who
is responsible for the
suppliel. one! he is checking

mum.
mum

m

the availability of e high oooteutntion. Meanwhile,he
hes not you ho edditionel bottles or 3. 8% marijuana
using; your import certificate 121310 ma on export licenee
from 31m. .1 m to can hin'oorly'nez'b wok end'if higher

oonoentretion euppliu can he obtained he will get them.
if thou
is unnotisi'hotory. perhaps you could check with Dr. Miro:
wont 0, supply or high comentrotion heohioh.

In the nonwhile you should cheek tho 1.85; and

Baywatch, I on sending you the outputs vhioh I
failed to bring with M. on well us an melyoie of e mic
depressive patient which Ton “keel u to do for him.

�60.“! MGM'.
tom .g.
u
v11}.
sheets.

N‘D‘o

we

'

3733. 15311, 1973

“*2“

mm obtained the nautical data.

as
all
m an.
new iron, some other mans. that. I should do m
I smz attend to than in the coming week. For. the
VG

do:

tn. may.“ 1n due-mud. as

ruin! the yam-mks.“

W119. what with“.

’

Sincerely yours,

Max Fink: .1 Mob.

Profs-gar o: Psychtwry

W13

he

0

.-

�Wm"

..

,

,

,

,

.‘7'm'mvmm-I

6/12/73
I

at

E

* aubco

tr

.

000: ~ haagggugg;

.

a. stipgnaa
1).

Ow

,.

$88.hoo

Volunteer. fees

12.300

a. Eonp1t¢;1x&amp;$;on

gggg

'

1,850

a. TQlcphane..§ostugc.

t2 hzlzzg

gagggce

to 12[§;[13

$56,151

$31.6h9

10.3%

1 ,9h6

o

1.850

600

no

560

7,000

:u,soo

2.500

3.330

2,112

3.310

1.690

1,620

328

3.593

1.680

15.300

$77,135

$603136

'

a.
§

Lab. gnnlysis:

r. Mitcrinl
3.

EEG

&amp;

A

suppaiés

rooording

h. Travel

,

.

3.921

.

1. Consultation. services 16.980

‘

1,&amp;18

yaw

my.

Uzlwqm-‘ruv

”WM

Wm

$0M

$137,391

»

,

mm

�7M73
May

17th,

1973

Cantu Stet-min. BM). .
Professor of Psychiatry.
University of Athens School of medicine.
Esinition Hospital,
73;, Vu‘illiui: Sophia

mm. arms.
Dear

in.

coat»,
I bare ma: arrangement! to

win in Nahum

mmreservation
to stay at the
I

from
have made

Britta“.

a.

on Tuesday afternoon. June 5th, and

should

Grand
meet
with
like to
you either
time during the max: two days.

that evening. or my
I should like to be able to review the data. which
Iwinbebrinsingvithmvithmmdym
”mitten; the subcontmt era-anion; and to work

with

m in planning the 1711;116:3311 ﬂaw.
I

to Maven Sun to 1:911 him
we written
be. in
I
became he has

the time

ﬂat will

Rhona,

bun particularly interested in tho next phase of
the grow. Should. ho be (bin to Join In. it
mm b. no.1: nimble, and I have extended tn
invitation to him.
I look forward to suing you.
ﬂy

best regards,
Sincerely yours,
Mu Fink. 11.1).
Professor of

10/13

thhm

�7313-651

April 2'! , 1973‘

Cetus Stefania, 1a.». .
Minna University Mica]. School,
Department of Paychictry.
Eginition Homitcl,
Th,

Vuiliuic

Athens, Greece.

Scrphics Av. .

Dar Cantu.
Whenever

I sit cad think of writing ta you the pomlcr
- "Is wane listening, in anyone there?" comes

song tron ’1776'
to mind.

Bumtcly, I

mm

have sent. by cis- c

muse

containing c

statistical prom-m cm! a tape which contains thou
on cmn tracks at the appropriate 3P1.

mun-.1 or

ham: been naked. to com to Wuhington on My 2nd to
mgotiatc the «tension of the contract. I an naming that
with your
the tuna raw-tea in our letter at MI: 15th
We

gnu-07:1, and
which

we

will

do our

at
but to 0min full upprcvcli

I an enclosing a cow c: c

all:

macaw

you about the status or our

given m by Rhea

emulation.

for m to ruin the progress of the but
nice the men-cry plums far the continuation
of the data of this
phuc and the
interesting cm. Should you with to cm to the United States
within the cm nix nooks, I mid be and to work with you hora.
mama this not be feasible, I would then suggest that you let
an knew what is 011311311 for you. sad I will try to com to Ail-3cm.

cmmlc

It

in

bar

but

few math: and to
of that withdrawal

W

regards.
aim-arch

mu ,

ﬂak.
m
weaves." Director
111.1).

90/11

M.

�~3__(,..1.

.n.

,3...

,W‘WF.

731-5568
Marah

5th.

1973

Dr. Costa: H. Stefania,
Athena Uhivcrsity medical School,

Dcparﬂnnat of Psychiatry.

Eginition ﬁalpital,
7h, Vasilissin Banking Avo..
Athcnl. Greene.
Dear Goat‘s.

cro progrouuing very well with tho EEG datg.
Banana: of sum: (haunt raeordn. v3 hswe don: the
regression aanlysea on 16 tubaecta, and this soon: to
be adoqunte to givv u: scan data far tho differences
bctuaan the variaun aonditiona. The bohaviornl data
which Rhos brought back with her has been coded and
aorrol&amp;tians between tha EEG and the bahnwiornl
intbrmation or. nuv 1n progrcta ~ sons having bcan
aompletud during the lust few days.
Rb

callcd Wishiagton on a number of
occasions during the ptnt wusk. but v. an not have
any more infbrmnkion. It I do not have a clear renponte
by uhruh 10th. I will «all, and it that. is no anlvor
by the 15th, I will @311 you. A copy at Khan's report
ta In which V: have tile&amp; with Dr. ssara is enclosed.
Khan has

my aoeountant hAs been over the receipt: uhiah
Rhea.brought with nor. This dacumentation in adequate.
Enclosed is our shock for tbs fbur inwaieeu of January 6th.

In order to obtain :n export license, 1% 1:
naecisary to file a whole act of docunants - which I did
on March

lat.

Rho: came bank must onthnnltstic rcgnrding the
canton: of tho work,'us 1311 as tho cooyerntion which
aha receivud. Mhny thanks.
my

best rognrdl.
Sincerely yours,

Fink, M.D.
Exacutive Directer

Max

Kilt:
ﬁnes.

�731-5131

February 13%, 1973

Castes Stefania, M;D.,
Prefeeeer of Psychiatry,
University of Athene School or medicine,
...

”mm.

,
.v

a.

Eginltien Hospital,
Th,

veeillieele Sophie: Av.,

Athens, Greece.

.v.,,.,.

T
.
v

.
..

:

Deer Castes,

4!!1;'4':~I

«rip

w,

van."

WW

Enclosed are cheeks-1n the emeunt at $13,365 to cover the
aeleriee for April-June. 1972 end catchermbeeember, 1972. I
will need the eencelled check: the these eeleriee as well as
the ones issued for Jhly~8epteeber.
Copies of the expense vouehere for $l,lho are also

necessary.

I em returning the other veueher requests and eat that
these be rendone. I have made suggestions on each, which.v111
ellaw me to meet the reqplrenente of the auditors.

first

Xon should knew thet in our
year. we were ellewed
some overhead for the expenses in Greece, end should there have
been dieelleweneee, we could
been on these funds. Since
June as. 1972 we next been lenied en overhead allowance. we

fell

eoneldered cancelling the eentrect hue cur interest in the
study impelled us to eecept e bed contreet. (Indeed, if I were
not personally involved, the Directors veuld have rejected
washingeen'e offer). To protect my Boerd, we must have adequate

reeerde.

You will reeell thee you rejected direet payment of your
personnel, using netlonel pride and year need to relete to the
start as levers. I eeeepmed your with. as I accepted the HIMB
deeend for e nn-overheed eontreet, to aeeeeplieh the mission.
sue. the rink to the Aeeoeietion in too greet end unless we
obteln adequate statements. eheeke, ete.. we cennet continue this

eontreet.
with

I

An

Rhee

will tell you, I em too fetigued with contesting
e threat of lee: of money fer ee little gain that

EIMH, end

unenthneiestic about continuing the eontreet utter June 25.
I have applied to RIEE for en exteneien, no es not to
Jeopardiee your chances. end will endeavor to support these
em

1973.

�Goat” Stefania,

$.13.

«Eu

Inﬁrmary

studies. but your coaperstion is critical

mutants

1:5

the financial

Sincerely yours,

Max

new/1.3

Emu .

\r
w
-«v-

,.
..

v.;—~:e~,m—v-;m«,um‘

my:

«'1va

r

w-wrm-qw-m

.,
,.

1973

mutation of the interacts of my associates.
briefed and will try ta amplify the“

and in thc

Rhea has been

issues.

..

lot,

Fink,

M.D.

�--wwrcmx7.-L

&lt;

731-51111

deruary lat.

1973

Castle Stethnis, M.D..
Protasnor of Psychiatry,
Uhdersity of Athans school or Medicine.

Rainition Hospital,

7h, Visilliauis Sephiaa Av.,
Athens, Greece.
Duar Cactus.

Rhea, Vbita, and

I hsvc read your

I

35

summary

report. and found

or intarost and significanca. Vb raviawud «gen 0: the
seetians and an: comments and auggeationa have been noted.by Rhea
who will review these with you in Athans. My own antes, which
she will amplity, are attached.
much

hnwn ankud

with ynu.

bar

rcviav the relieving technical issues

(1) The report has been aunt to Dr. Rdbcrt Petersen.iﬁ§wgl

I balieve the data is sufficient far thalr review

r.

and dacision no ta
any eontinnttion qr «xtenaion. While x hawk rumindad than of cur
agreement, I am not sanguine thnt they will be dble er willing to
umvm.w1th any slacrity; and vauld suggegt that. shauld yau wish to
eontinua this interaating tyye of work, that alternate sources of
anymort be sought. I huva diaeusseé than: with Rho: and she is
prepared to assist you.

(2) Bath the raport in August and this report taka little
cagnisanoe of the contributian at my unneeiates tn the studios.
Recognition of eontribntions is always a delicate issue and when
w! discussed this in Copanhagan, I trusted to yaur Judgement to
protect tha interest: or the staffs invulvmd. This report seamed
dafiaiant in this regard and I hawu made sumo amenanants, whiah I
trust £411 much your approval.
(3)

we have redunea

all the

EEG

cage: by perioa analysis, and

huvu 16 sﬁbaocts camplete with 5 cxparimontn each. The initial
proeessing has been done using our linaar rugreaaion analysis model.
The drug eonditions are distinguidhdhle tram placdbo, in patterns
similar to that reparted'by Vblawka and Dorubush in their earlier
studias in v.3. voluntaers a&amp; lower doses. The analysis was done.
including ﬁhn post-smoking period and the postnteating EEG in a
single analysis. A: the varidhility is high postuteating. additiannl

analyses are in prograaa using a quadratia regression modal, for
the firnt pastanmoking period. In aﬂdition, we are aarrying out
sums npacial analysas to amplify the changes in the alpha bands.

�Coatee Stefenis, M.D.

February let, 1973

~2—

These date should be complete in two weeks. we would like
to undertake correlative studies, of the EEG, heert rate, eelr~
reports, and some task performance data. volevke has used e
"forced regression" analysis model for our heroin and cannabis
date with success, and'we propose some similar studies here.
Rhee has e list of subjects and date which we will need to carry
out these analyses.
'

(h) Ae‘I hawe written to RINK and discussed with you. the
findings of these studies are of considerable interest and we must
give thought to both the mode one time of presentation. we have
dieoueeed the question end Rhee will discuss the enclosed
memorandum of our suggestions, and hopefully we can outline e

set of steps which one

needs.

eeooumodete our mutual

contributions and

Rhee is bringing the battery you requestea, es well as some
cannabis materiel. On her return, we would like to send samples
of heehieh, and residual marijuana end THC»A~9 to NIMH for assay,
end I would appreciate your making these small samples available.

(5) The initial threat for this study was the observation
elowing reported by Professor Mites. The EEG records of
the heehieh smokers were examined by h neurologists, and the controls
by 2.‘ But, a critical reviewer could argue that the obaervers
knew which records came from beehieh smokers and which from controls.
Perhaps, it would be worth the effort and coat to code the 60~7o
reoorde end ship these to an independent, experienced

of

EEG

electroencephalographer of known reputetion.for a detailed report?
Rhee has some suggestions for candidates in the v.3. and Europe.
.

(6) There are problems

in our book~keeping thick is of the

following nature. The auditor: will require "belk— ups" thet the
salaries were paid as specified; and that the expenses for
supplies were paid. I believe you are depositing our check and
issuing your checks for the expenses. I need the processed check
or its coyy for salaries; one the bills with checks for other
expenses. It cash, your initials or one or your staff certifying
e eeeh payment should be eatiefeotory.
Again, my congratulations on e fine report and my best regards
to Adele and your eeeooietee. I look forward to seeing you soon.

Sincerely yours,

.yr/ia

Mix

Fink,

M.D.

�gaggestions for Presenﬁatian
A; Se

ate

1. (a)

A

(b)

A

Re

social, madleal, neurological aummnry of the two
population sampler. with emphasis on the soainl
characteristics, snaking history, work and family
charactariatica. Ineluaing a hiatary of the sample.
Stefania. Boulousouris. Gefou, Liakos
description of thc undieal aspects ~ phyaiaal
examination, mantal status, EEG (clinical), Echa»
EEG, pulmonary.

ﬁvefanis, Linnea.

Tam,

etc.

‘2. Psychalogical Characteristics of the two populations 9

I.Q..

W118

subtext:

and pwofile, mamory

Darnbush. Kbkkavi

tasks.

3. Acute Experiments

(a) Ensign, goals, dosages used, with type: of psychiatria
response, esse deseriptiona.
Btefunin. Boulougouris, Dorﬁbuah

(b)

and heart rate; relatinna to each other
gal! ratings; tolerance?

EEG

Vblavkn. Tam, Fink

(c) Paychologieal

&amp;

and

to

stetania

teat datagw , pupils. etc.

Kbkkevi, Listen. Dordbush

h. Tolaranne Duvelopmant: latﬁer to
Fink, stafanis
5.

B.

A

1.

EEG

JAMA.

eftaots (brain effects) of chronic hashish
to editor.
Stefania. Tom, F1nk,Vb1awka

~

letter

siggéc Vblgag

int

t

History or atuﬁy; Alma.
ﬂank

2. Ghamintry or hashish; history of hashiah uaa in Greece;
hiatcry of sample.
Mirna

�n

m&lt;

‘5».

suggestions far Preaontation (Continuga) * 2

of users
Idcntificaﬁion

3. (a) Sample
390131

Mhdieal

Heurophysiolagical
Psychologieal

Seton

Goran

Gefau
Liakos

Tom, Vblnwku

Kbkkevi, Dorﬁbush

(b) Sample fbr control

Stefania

(a)

Stefania

Camparisona

h. Acute Experiments

(a) Goala, design

Stefania and Fink

(b) History; methods; aescription
of subJects; aropwouts

Stefania

smoking times.

«A

behawior.

My

rim

intarticw

n.

WWW

(c) Prychologicsl

tasks.

"0....va

an,

(d)

EEG,

and perfarmnnce

heart rate.

Dorﬁbuﬂh and Kbkkavi
Tan and Vblnvka

uKWI—rl‘w?

(9) Chamistry of substaneas.

Miraa

(r) Significance fbr drugs,

Fink, Stefania

mm

rr-Irw

Jar-WW";

WW.

”my

a...“

-my

mmY’w-‘Kx—w—a

«menwrrlr

u

«

warn-pr:

-——.-

v

r

.n'"

tolerance, interactions at
comgonents.

5.‘W1thdrtral Experimmnta.

atefunis

�15

antrgl«85g§1e

”

,

Egblﬂ’

..~

.
r;

'

why ware patients admitted to hospitals?
Any relation in tins to smoking hashiah?

c

A.

-.—

.M‘

there differencal 1n tgﬁes at Jabs?
factors eould contribute to tha difference
in two groups in rnta umployed?

Employed: ware

.,.V

.A

What

all-,m.

v

,...

Should E30 racords be rdviewod by independant
EEG'ar using coded records?

.

P
A

.

e.

n

'g‘

~

differences are troublesome.
they reflect effects of drug use, they vuuld

The 8TH and “£18

If

.~.,n..-A-n-

rcflect brain ahangea

&lt;n.‘-_.

differcnees? If nut.

~

do vn have

how much weight

given to these solitary findings?

H

-

”gym”

2

3%..

a!

nge g;:

8-

other

"

is to be

tannea
The aneeaotal stamanents dbout #7

are important

roflaatioas of tolerance. ﬂow long does it take
the men ta develop tolarance? This man ware he
to be tested again. could give an idea (antuming
ha is using hashiah).
not an analysis or aovnrianca ha a better
model, since aubaeets differ widely as to starting
levola? (toe Diagram II - page 33). This in clear
in diagrams IV and V, where dose effects and initial

Would

level

seam

to interact.

aritienl graph refleota one of the principal
effect: of eannabis. If the grayh 13 correct 78 mg
TKO a; marijuana has a great an effect as 160 mg
This
THC

as hashiah.

What

are the significant

i !D
Aua&gt;c&gt;n
The heart rnta effcet ulna
relationships?

(or)

A

n

B

C

parsistn for much longer
than anticipatad. Are A, B, and/or 0 still &gt; D
at 10, 15, 20 minumen postwbreak (3 75 minutes poat~
smoking).

Ara

these to be intoryrotad ta the result of

not drug related?

RV

and

�Quastiona (Continnad)

-

2

TEE content. To vhnt extant
what thqy wnre getting?
(or
guess)
did
Are that. data sufficiently consistent or reliable
to allow name canaecturea that aalfwrating is related
to dosa cf THCwA—Q while heart rate is not?

5g;_8elf ratings fallow our
aubjanma knaw

51;.Hhat is "fault index"?

hE.

to interpret these as drug effect at 30‘ and
practice affact (or loss of drug effect) at 70‘? acre.
too. response is related to EH6 content.
Are we

:9. Data far grineludaﬁ. Is
wall?

it

available for other tests as

6. Behavioral responses scam most marked in a 2:?
subjects: ho, an. In 2h, 35. 38, and El thnre in a
raaponae to placebo as «:11 I: there any alum in personality
or amount of smoking done in an and ho to relate to the
sevare raaponse?
.

�‘

(mentions (Continued)

A.

-

3

5118'.

B.

@@

Cl
1).
I

E.

�Contigued Sggngrt

Manner,

1. Ford,

2. Greek funds
3. IBM

*'

m,

Howard Enamels. Dreyfus.

- unassis.

"80¢

Suggest Stefania and Mira: deeide if study is worthwhile and,
plan to approaah founaations with these pilot data.
7,”,

&lt;._

”yr”.

,
~09».er

If

he niches v.8. intervention, nocda an agreement between
Dornbush (who will have to go to agencies) and himself;
or ?rcedmnnd and Dornbush.
‘

Jam

Suggast project leave
3 your support.

NINE

and seek more "indepandent" and

��W

.F—

‘7"

‘

’

RoberW’PéterseﬁTPh—U.
Chief, Center for Studies of Narcotic and Drug Abuse
Nationalinstitute—of—ﬂenﬁﬂetlth-~—~w~—~ v
5600 Fishers Lande

“a

_

W

,VﬁchgvilleArﬂand
Dear Bob:

M

NW

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W

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THC ~

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3’6

$2.?

_.__

~

W

VA‘

7—“

elaboration of the characteristics of the control population
and detailed comparison with hashish smokerswill be the subject
{m
of the January 15 progress report.

_Ar_1

[7441 WWW
36 J-Zé
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——

M __4H

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28

WWW

_

7

cgntrols. A deiaihiféﬁﬂﬁmﬂimmmiﬂshnserimsincludei_ WWWin the report sent to you in August. Thus this paper represents the addition
of/ controls which were absent at that~—‘time.
v"_—i——”_
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October 15th
the
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                    <text>ww;m'v‘

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Enelae‘ed are fear aimed copies at the macabre.“ between
bhe Inter-reunited?Aesoeietien for Peyehietrie Research, Inc.
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rector)
Undmeiby or Abbene Wheel of medicine (I
extend!“ our eubeentmet be December 31. 3.973 from the present
bee-minutiae date of septeeber 30. 1971. The eubmbmt else
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euboontreet bee been signed by the Preeidenb at the
dementia end by Profeeecr swan Senrpeleroe as Director or
the Univereity (Mature) ﬁenpitel in Athena Professor
Murderer Geo signed the Miguel mbeenbrect.
‘I‘he

I dimmeed the eonbente or the subcontract with Profeeeor
deem Stetende. who in the project director in Athens, end

Protee'eor Beerpeleeoe. in

w recent trip be

Abhene.

plmed to bell. you theb they here eerried net the fire:
ﬁre portion at the study press-en with mute-nun; ebbentdbn to
the mum of our progress and we ere menu: grebiﬂedfby
their eeoperetion. I knew, Greedy. that the Eebienel Institute
er mu). neelth end the American people will be met interested
in the ﬁnance at this “My.
w bhenke for your miebenee.
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me,

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Executive Director

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                    <text>7BSB~82983
20 December 1973

Peter J. Fell,

Fisooo, Ltd.
Loioeotorshire

M.D.
L311

OQY

ENGLAND

Peter:

Dear

I look forward to your visiting my laboratories at Stony
at January 17. I underetend from your secretary that you
will be arriving from Toronto. There are connections to two
Brook

new York

airports, LaGoardia and

John P. Kennoéy.

The beat way to reach the Buivereity

in

by lioooeine from

either airport—~travel time is 1-1/2 hours. When you arrive at
either airport (LaGuardie is 10 minutes closer). oak for the
neareat euborban limoueine telephonee and use the one marked
"Long Island Limoueine." They will give you the eohedule for
the next limousine to Stony Brook and you will be picked up at
the terminal, near that phone. -Tolephonee are at each major
terminal. The coat ie $15.0U.
You may

either take a taxi

from the limousine depot at
(The
from

call my number and I will pick you up.
railroad station and limousine atop are eight minutes
Stony Brook or

campus.)

Should

it

be poeeiblo for you to change your schedule and

arrive the night before,

you are welcome to etay

drive to Stony Brook with

airport at (516)
my

466v54ﬁ4.

me.

at

In that event. call

my home and
me from the

I look forward to your visit. My beet regards to Vi and
boat wiehee for a happy and healthy 1974.
Sincerely yours.
Fink.
m
Proteeaor of Psychiatry
MOD.

MF/oio

�</text>
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                    <text>«can. -...— wu-r.

»

.

11' I'th-c—d

,

amp-gaymmur—vmmwwm»-mu.-.—W-ww

"NC-r—

»:vvwmr—

‘Vy

~

w

c,” wum-mwwye

'r“_l-~vnr\A-iu—u"—-Hpi'rr7"':nv.')cc|mn

,w—

.vv, 1u\‘i."vm¢

w...

c

an

73SB—739A

October 15, 1973

Alan Ramsay,

3.9.

medical Conuultant
Cantu: for Studias of

Narcotic and Drug Abuse
Rational Institute of Hantal ﬁnalth
5660 Fisher Lana

Roam 11¢, Wayland
Ra:

HEM

20852

h2—73*269,

Dear Alan:

arc writing to rcqucst yarmiasion (a transfer the sum of $k75.00
v.5. travel to tareign trnvel to permit representation at the EEC-HA3
Connittaa on Problems of Drug Dtpendante meeting to be held in Matteo
City, Hatch llwlé. 3975.
from

we

Nb

believe that participation in that aceting would cantribute to

out otudy of thc narcotic antagotitto. As ycu know, these matting:
rcpruscnt tho tingle principal coavocatian of internatianal scientists
with intotctt 1n narcotics. and utttndanca at prior meeting. has been
most

useful.

Sincerely yours?
Max

Fink. H.D.

Praia-sot of Paychiatry

HF/cin

n.»—

n

.u c—‘~-W‘m"—t--’-—

�</text>
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                    <text>7383*73383
1 October 1973

Turan m. 1:11, M.D.

?rofesaor

and Associate Chairman
of Clinical Neurophysiology
5action
Chiaf,
and Psychopharmncology

Séhoel of Hbdtcina
University of Missour1-Columb1a
5400 Arsenal straet
St. Louis, Missouri 63139
Baa: Turan:
The pragxam

to participating.
my

for the

ACMP

Is ancellent

and

I lack forward

best regards,
Sincerely,
Fink. M.D.
Profasaor of Psychiatry
Max

HF/cis

�</text>
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                    <text>7483-07953

25 February 197a

Prof. Dorothy Krieger

mount Sinai School of Medicine
Fifth Avenue and 100th Street
New York, New York 10029
Dear Dorothy:

I very much enjoyed our talk at Alice and Martin's anni~
versary celebration. Because I was puzzled by your comments
regarding the availability of AETE fragmenta, I wrote to my

coworker at 033, Dr. Honk van Riezen. He explained that.
through a series of oversighta, changes in administration, and
administrative enafuo. they had failed to send you the material
you requested. As the extract from Hank's letter indicates, the
fragments will be sent to you as soon as possible. He also is
interested in the rationale for trials of OI~63 in Addison's

Disease.

I

am

planning to attend the convocation on behalf of Morris

Bender on Friday, March 15.
for me to visit you earlier

to

visit your

fragments?

call

at #:00 p.m. would it be possible
in the afternoony~about 2:30~—first.
and its
perhaps your secretary would

laboratory and, oecond, to discuss

If this is feasible,

my

office at

My

best regards,

(516) 44A~24&amp;7.

ACTH

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cia

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                    <text>it,

February
Rdbert Robinson,

M.D.

A. H. Robins Co.
1&amp;0? Cummings Drive

Richmond,

1971;

Virginia

23220

Dear Dr. Robinson,

the initial dose-finding studies
of ARR-2277 and are satisfied that single 10 mg doses are safe and
elicit systematic, dose-related EEG changes.
We

have completed

have also completed the assays of the canparison
substance, haloperidol, and are satisfied that single 6 mg doses
elicit systematic effects. We believe that this dose may be above
threshold, hooever, and we are exploring an additional group of
We

subjects at

It

mg.

enclosing a copy of our work-sheets rOr your
information. I have asked my staff to summarize the data of these
initial studies and a report will be sent to you as soon as it

I

am

is completed.

‘

Should the h mg haloperidol doses be below threshold,
we will undertake the comparison, classification study of placebo,
AER-2277. and haloperidol using 10 mg and 6 mg doses respectively.
that dose will be
It the h mg dose of haloperidol is satbsfactory,
used. In either case, the systematic study will begin before the
end of February, and should be completed in 2 months.
Thank you for your

patience, and

my

best regards.

Sincerely yours,
.v

,A

.uy

WNN'W'IV‘wh-rrw-u

-

Fink,
th
Professor

M.D.

of Psychiatry

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                    <text>3

Jannlry 1974

7483*00783

YILE
Max

Fink, M.D.

Stave Kahn

patterned in a moat satisfactory fashion during
the past 91: months. Ha ha: asaumad additional responsibilitiaa
with the departure of H13. Poiniar.
Mr. Hahn haa

Effactive January 1,

$8500/yaar.

HF/cia

1974,

his atlary

13

incraaacd to

�</text>
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                    <text>July 2.
TO:

Stanley F. Yolles,

FROM:

Max

SUBJECT:

Fink,

1979

M.D.

M.D.

Proposal by N.S. Lehrman, M.D.: "Psychotherapy with a

Recidivist Chronic Schizophrenic Population..."

This

is

l.

description of the characteristics of the

an ambitious treatment program dedicated

to a

psychotherapeutic interaction in chronic, relapsing schizophrenic
patients. The study is based on an uncontrolled, impressionistic
study in which "More than 30 chronic, repeatedly admitted...
patients have been receiving treatment in this fashion... since
November 1978, with apparently excellent results so far...".
Since neither the case description, the intervention, nor the
outcome criteria are described, it is not possible to assess the
success of this "intervention". If the therapy is so rapidly
(November 1978 — May 1979) effective, it must be powerful indeed,
and we are entitled to a better description. Specific questions
that should he answered to allow a reasoned review are the
“
following:

selected.

A

°

30

patients.
'

.

2. Number, frequency, duration of interventions .
3. were medications maintained at pro-therapy leVels, or
changed? If changed, how often, by shat criteria and with what

outcomes?

.

,

u

,

b. What are range of changes,

which are the basis

their incidence,

for' 'excellent results".

duration,

and

f?
-\
*

a

*R

.

}

are the characteristics of the panposed psycho—
therapeutic interventions, particularly, how are these distinguished
5.

from

What

established therapies ordinarily available in the

institutions.

:

OMB

]IX
.

I

'.:\A\.“
\

�~

If; i d

\‘r

89F. Y°1.QB,

Until such
for support.
MF2bc

2.

MOD.

data. are provided,

'

«1111?

2! 1979

the study cannot be recomended

�may

To:

8. F. Yolles, M.D.

FROM:

Mex

SUBJECT:

Fink,

9. 1979

M.D.

Replacement for Mr. Robert Bienatook

I

would like to recommend the appointment of two young
women, Miss Stephanie Orson and Miss Jane Engele to replace
Mr. Robert Bienetock. Each of these appointees is recommended
on a half time basis, effective June 2, 1979. Attached are

copies of

their

Thank you

Mszc

Att.

Curriculum Vitae.

for your help.

�October 13, 1978

Stanley F. Yolles,

HSC
SUNY

at Stony

M.D.

Brook

Dear Stan,

I am writing this letter on behalf of Dr. Kenneth Tardiff,
in support of his application for promotion to Associate Professor.
I have known him since he Joined our faculty in 1975 and while I have
had little opportunity to assess his clinical or research
ability, I
have worked with him th the Psychobiology System, and
is
that
it
I came to appreciate his skill as a teacher and his interest there
in the
students. In the year that we worked together, I found him enthusiastic,
dependable, and appreciative of the problems of the students. He worked
well with
us on the committee and

facilitated

my

teaching.

It is from his record that I have to assess his research
clinical skills. It is clear that he has the academic training and
interest, and his publication list and independence of research efforts
and

during the past year indicate that he has the basis for a research
contributions of high quality and innovative creativity.
fellow

of the Department, I have found him
and quiet. In the committee, he has
been prepared and presented his work welll I believe he carried outalways
this assignnent to our satisfaction; I surely have no awareness of any
deficiency in the training program or in the appreciation of the students.

warm,

As a

member

interested, restrained,

From a number of points of vies, I believe he has achieved
the record which will Justify an enthusiastic recommendation for promotion
to Associate Professor of Psychiatry.

.Sincerely yours,

_

Fink, M.D.
Professor of Psychiatry

Max

�April 11,
8. F. Yolles,
Pink

1973

Institute Director

T0:
From:

N.

Subject:

Appointment of Dr.

Y.

Papakestos

will complete his third year of residency
has applied to me to join the LIRI research
programs and I would be pleased to have him work with us, if we
could generate the support necessary.
Dr. Papakostos

training in June.

He

In 1977, Dr. Asnis was a full time employee of the
Division of Clinical Science. When he went to the V.A., he went
as half-time LIRI and half—time VA. When he resigned in January,
I recohmended that John Lee, then on 'soft money', be appointed to

his half-line at

LIRI.

Dr. Lee will be appointed to 5/8 VA in order to take
advantage of the rules that only employees at the VA who are 5/8
or more can apply for VA grants. That will occur in May/June and
will leave 1/8 of a line free at LIRI.
Whatever happened to the

other half of Asnis' line

?

it permanently 'lost' ? Is it possible to use that half a
line plus the 1/8 from John Lee to create a 5/8 LIRI line, possibly
for Dr. Papakostoa ?
Is

Two issues are at hand: the abailability of the 5/8
line and the possibility of appointing Dr. Papakostos to that line
if available.

�){1

£11in

March 23. 1978
MEMORANDUM

TO:

Dr. S. F. Yolles

mom Dr.

Max

Fink

I am writing to recommend the appointment of Dr. Leon D. Hankoff to
the Department of Psychiatry. at the rank appropriate to his experience.
I have known Leon for two decades, primarily as an administrative physician
who headed local hospital departments of
psychiatry. Three
ago, he
consulted me with regard to the development of a study of theyears
behavioral
and EEG effects of benedialysis. A grant application was
prepared but was
not approved. In working through the details of the protocol, I came to
respect ht! clinical experience and judgement, and his enthusiasm for
research. He is skilled in the administration of a psychiatric clinical
service, has an interest in clinical research and has supported research
studies of members of his staff. He would be a valuable
addition to our
clinical service.
He has served as a teacher at the various schools with which
he has
been affiliated—- Downstate Medical Center and New York Medical College,
and has taught social work students. His skills as a teacher would be

most

useful.

It is a pleasure to recommend his appointment to a senior position in
the faculty of the Department of Psychiatry and Behavioral Science.

bc

�February 20, 1978
TO:

S.F. Yolles,
Fink

M.D.

From:

Max

Subject:

Leb~0ffice Building

are completely out of the Lab—Office building as
of today; except for the air conditioning unit in Room 8323.
As soon as this is disconnected, I vill arrange to have it stored
in Great Neck.
We

to have the
Brookdale.

is a better source of payment, I will arrange
paid for from the Psychopharmacology funds at

Unless there
move

�</text>
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                    <text>‘

Form ”91.28 Adm.

_

State of New York
Department of Mental Hygiene

LONG ISLAND RESEARCH INSTITUIIE
State University of New York at Stony Brook

2

"

,
'

‘

If ﬂ)?

,5

-

._\

’

My!”

Health Sciences Center 101'
Stony Brook, New York 11794
STANLEY F. YOLLES.

DIVISION OF CLINICAL SCIENCES
MAX FINK. M.D.. DIRECTOR

M.D.. M.P.H.. F.A.C.P.

INSTITUTE DIRECTOR

(516) 444-2447

(516) 444-2163

March 20, 1980

Stanley F. Yolles, M.D.
Professor and Chairman
Department of Psychiatry

Health Sciences Center
SUNY at Stony Brook
Stony Brook, NY 11790
Dear Stan,

I have known of Leon Hankoff since the early 1960's when he was
a research associate of David Engelhardt and Norbert Freedman and
published articles in Psychopharmacology. After that research period,
I

he assumed more administrative roles. Our first working association
began last year, when he joined the Stony Brook faculty to enhance
'

the clinical services of the Department.

Since coming to Stony Brook, he has organized the clinical
services and is responsible for their continued management. In this
service, we have gained from his experience.
His principal interest is in psychiatric history and he is
studying both the phenomenon of suicide and the interrelations of
religion and mental illness. I am unable to assess this scholarship or
his teaching ability since I have had no occasion to review or observe
either. Despite the demands of the clinical service, he has continued
his studies and has published an interesting book on suicide. I have
often participated with him on committies of the Department, and recall
that he is usually with the majority.

In personality, he is friendly, out—going, and soft spoken. He is a
am encouraged to recommend the

dedicated member of the Department, and I
renewal of his term appointment.

Sincerely yours,

W

Fink, M.D.
Professor of Psychiatry
Max

MFzsl

�</text>
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                    <text>ThSB—IOBSB

April 11, 197h
Mrs. Gail

M.

V. H. Winston

Parker
&amp;

Sons, Inc.

Street, N. W.
washington, D. C. 20005
1511

K

Dear Mrs. Parker:

I would appreciate your getting the following informa~
tion to the responsible officer at V. H. Winston:
I have been asked, by Science, to review a volume of
Convulsive Therapy published by Walter Eeemen. Indoing so, I indi—
cated that

more

of the issuee raised by Dr. Eesmen were discussed
extensively in "Psychobiology or Convuleive Therapy".
some

Miss Sylvie Eberhert is the responsible person in the
book review department of Science. If a review copy of our
tolume has not been sent to Science, 1 would appreciate that
one be sent to her at AAAS, 1515 Massachusetts Avenue, N.W.,
Washington, D. C. 20005.

Sincerely yours,

Merd

Fink, M. D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 31,

1989

Muriel Young, M.D.
E-43

SK-Beecham
1500 Spring Garden

Philadelphia,

PA

Street

19101

Dear Dr. Young,

produces a systematic amnesia which is proportional
to patient age, frequency and number of treatments, electrode
placement, intensity of currents, waveform, and associated
medications. The amnesia is reversible, with an improvement in
time after the last treatments such that patients no longer show
measurable deficits from 6-12 weeks after the last treatment.
There are some patients, however, who consistently complain of
amnestic disturbances and these have been associated with
specific currents and electrode placements, and some modified
frequencies of treatment (like multiple treatments in one
ECT

session).

The animal model

(Electroconvulsive shock- ECS) has an
extensive literature as the effects of drugs on ECS induced
amnesia in rats or mice is a standard pharmacological test for
almost any psychoactive substance. In man, there have been
systematic trials of some putative anti-amnestic agents on the
ECT process, notably with pemoline (Cylert), ACTH 4-10 (ORG
2766), piracetam, etiracetam, vasopressin, and l-tryptophan. Many
of the studies have been well designed with adequate controls,
but the results have generally been disappointing, i.e., the

effects

on

ECT

induced amnesia have been modest.

recent trial, a collaborative study of
pramiracetam, has not yet been published or officially presented,
but the 'grapevine newsletter' states that the experimental and
control groups were not distinguishable in the effects on tests
in a cognitive battery but that the experimental group fared
The most

better

on improvement

scores.

�on hydergine and ECT in press in the J.
Psychiatry finds an effect on improvement scores for the
experimental group but not an effect on memory tests.
A

report

is

The ECT DATABASE
a service of the
CONVULSIVE THERAPY
readers and authors.

to its

citations for memory enhancing, nootropic,
elicited the citations which are attached.
a

basis for deciding whether the

ECT

and

clin.

editors of
Culling the 4500
specific drugs

These should give you
model may be useful in the

assessment of your compounds.
As for the usage of ECT in the U.S., we lack any good
assessment. The last measurement was done in 1977 by the APA Task
Force; similar assessments were done in Great Britain in 1980 and
Ireland in 1982. These find that usage is about 4.1 to 4.5
patients treated annually per 10,000 population. These figures
should be corrected for the fact that ECT is rarely given to
persons under 20 years of age, and more often in patients over 50
years of age. It is my impression that usage is increasing,
although my impression may be faulty, resulting from the number
of inquiries about ECT which I get each day.
I trust these comments are useful.

Sincerely yours,
Max

Fink,

Editor

cc: J.0. Cole

M.D.

�</text>
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                    <text>“arch 8,

1965

Dr. Akita Yokitak:
Dopartnont of Heuropoyohiatry
Faculty of Hadicina

lruahy Univoraity
Fukuoka, Japan

Dear Dr. Yukitaka:
Dr. Iakumi Ikuta has recommended your appointmont as raaaoroh

fellow in this Boportmaot of Psychiatry. and has.subnittod a copy
of your earriculon vitaa. I am pleased to oonoidor this application
for we are interastad in alpanding both our laboratory and clinical
research program». We at. now proooasing the appointnnut of an
additional tasaaroh aoioutist for our animal stuay program. whilo
our principal studios era with patients. it is in our animal labor~
ataxia: that vs would Ilka to proviéc the next additional progtan.
have in mind oro studios of the changes induced
in the cortical EEG of dogs. we ato of the
Opinion that changes in tho olootroanoopahlogtam reflect tho spacilic
changes of coapouods, and that wa might be able to rolato tho patent-a
in dogs to thoao soon in pationts.’ For this purpose wo would like to
but. alaottodoa ilplantod abovu and bonoath the dura for ptolonsod
pariodo. Theta dural olontrodas would to connected to lead sockets
aitixod to tho skull. Racording would than to accomplished with
long laad.uitoa in a ftaaly moving animal in a confinad encloaora.
The

projects

we

by spychotropic drugs

A aaoood study prograu is an evaluation of the chansas induoad
by drug; in psychiatric patients. comparing the difforont patterns

as soon with quantitativa EEG uaosuroa. In addition to the oonvaotioual
ftaquaooy analysora. WI at. oxploriog applications of digital eonputar
mathoda. that: is a 3raat oaal of study which should be accomplished
by atatiatical quantitativa aaaaurouanta in tho 3365. using tho
quantitative tools of tho laboratory to support tho individual

uninctioos.
/
If cithor or both of thoaa
,

programs interest you, I should like
to taoaiva tho nann-of thrao rcfcroncoo and your perniuaion to writs
to than. I baliava that Dr. Ikuta will writa at graatar longth and
can axplain in your ova languaga the prograno dovaloping hero. I
look forward to hoaging from you.
‘

\

,2:

i

Sincerely yours.
Fink, H.D.
Profoasot of Psychiatry

Max

�</text>
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                  <elementText elementTextId="101838">
                    <text>April 1,

Akita

mm,

war Dr.

1965

H. D.

Yukitake:

Wmformlemrofmzu.
just written:
Dmlnmagamd
lemmtom‘.
Iham

W1,
Assam-asIhavemW'
muralwinheplewedtomidermappoinmm
tomsmpmtmdwﬂlwritetoywatmttim.
Davakiaamsuggssmd.

Sineamly yours,
Max

Pink, H.

D.

meessor of Psydziatxy

�</text>
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                    <text>May

Akim

Ymitm’

a,

1965

N.D.'

Instructor of Mommyddauy

'

upar'tnent of Neuropoydxiatry
Faculty of Medicine

Kyushy University
Fukuoka, Japan

Boar Dr. Yukitake:

I have moaivod letters of ,mfmnoe from Dru.
um, and Sakumi. I am pleased to nomad
yaw appointment in the Dapmmnt of Paydaiatry as a
Research Fellow. Insofar as I have not had a specific
date, I have made the mocmnndatim effective Sepmmr
15, 1965. Inc University should act on this mmndatim
within the next mouth, and if they aooopt it, I will
Inanaga,

'

forward the appointment.
'

In the mamhile, would you please write, indioating
whether September 15 is a suitable date for you, or would
you pmfer mother starting data?
,

Sincerely yours,
Fink, Md).
Professor of Psychiatry

Max

�</text>
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Hampawhiatry
WWW of
of Mmychiatxy

Departmt
'

Faulty of Misha

Mmity

am

Kyushu

’

Ihavemivodyan‘lettorof thy 22,

indicating that

ywmuldbcavnilabhtojoinﬂwstaﬂinﬁmnawmtm
Invemtyut mivedfmlmtﬂimtimfm
mmivmityafﬂiaawri «mingﬁmappointht, buthave
bummmﬂmt.mappoinmispossiblemtﬂafterMy 1.
Imwri’cing. ﬂnmfm. munymﬁntlwiuagaininqum

W1.

ofﬁnmmofﬂnmdimlsuwolmgwdingmappoinmnt
arlyinJulymemnwiumymaamaaIMVeany
duﬂnitoinfmtim.
Sincerely

m,

that. Fink, H. D.

Profesam of Psychiatry

�</text>
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,
.....n.

M

”3.9“...”

w...

--——-

Fm...

.,

«.mwwﬂﬂn,‘

-

gmw—

Am.

_.,.~.n«—n._.....,.

-mm-7mv:.

m—

~.~..-—~

Akin Yukitakn
Instructor in Nemupsymiatzy
Dr.

Department of Haumpsydaiatry

mm

Pawlty of
Uniwmity

Kyushu

Nu, anm

Dear Dr. Yukitake:

Wmformlattnr
theMmmofthDopar-mmtandmbnntoldthatmfmcb
for than
of this year are mutually obligated, and I
mid agree that you should look fora position in mower lab-

war

Thank you

of October 7. I hang inquired of

for your internist.

manly ywm,
Hm:
HF: jam

Pink,

PM).

Manor of Psychiatry

�</text>
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                    <text>October 21, 196‘:
Dr. Arthur

Ywiler

Ramaydﬁatdc laboratory, T, as

Canter
Wamtive
hum
and
mm Sauna AW
Loo Angules,

mm:

California

90073

Wim

MImmmdfmmpchmvazymohm—
mardingﬁmposaibility
medbySm's
ofyoummidaﬁngmappoinmnt toHissmzi. Ashe
myhawmtidehadplmitomthismﬂatc
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own not make adecisim mm today.

but mfortmatoly

Immtabletommmmiaﬂmismth.

Ashmyhawtoldyou, Ihnveexpmdedtm
Imtitute's budgetary mqueat for 1985-67 to «amass

of the pemamel and

aquimt suggestims made

by San.

m

Immutlwouldlqmbyﬂnmiddlaamemmm
the
mammdatim will be and with

Gem's
I look toward to calling on you.

Mad

that in

Inﬁnmeantim,iftknowasimpomitsonom
youstopbySt. Inuinmdvisitwithus. W,Imu1d

ofyumms-oommmlsImuldbaplwadtohave

lmkfmdmmmyoumtwithowstaffmmidmts

mdhaveywmnﬂm

bothinMid'tigmdealifmﬁa.

ofﬁnmcporimmyouhad

With best regards.

Sinoemly yours,
131719

me.

Dr. San Gershcn

Fink, PM).
m
Dimtar

�</text>
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October 29 ,
Dr. Leo Zach

196‘}

350 Cmtrul Park West
NW York City, New York
V

Dearleo:
warderful days in Europe and Israel

are
emetbazynwandbothmthaendlmgettingthe
My
My

urge to travel again.

ealendar says that

inNewYozkﬂmefiretweekinDeoerber,

I will

be

andeouldbe

grateful if you could set aside some time mmeday, Friday
or Saturday morning, December 3rd, mm, or 5th for you
to petal up any holes that developed as a result of drinking Turkish eoffee. I m scheduled to be in meetings
during each of time days but wwld prefer coming to you'
first. If that is not possible, I would like to com be-

tween noon and 2 p.m., gladly missing the usual business
mn' e lmoheon.
.

My

best regards to Dr. Lillian.
Sincerely yours ,
Max

Pink,

Director

mf/ls

14.)).

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                    <text>April 6. 1965

m».
350

be End:Park West

Central
NarYazk, New York

mm:

Itmaphasumhavingymvisitus,mdlmym

Myoucm
mmtmtﬁnlibmypmmmmtmdng.
mfmﬁnmlmcdmmt,wmodmdecidodtohaw

mhmuithmtaomdmmﬂuwogtmmmurday.the
full citation list was printed.
Ihawymmglnvesmdwineimrbﬂngthmoramd
manta you. Mybut magma tobﬂlim.
81110331211;

Max

Fink.

yours,
H. D.

‘

Professor of Paydﬂatry

�</text>
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                    <text>Vs“

Deaeﬂber 18th. 1972

Lillian Zach, Ph.D.,
Dirtcﬁar.

Behool Psychological

services.

Chnirnnn. Dn’nrtment of Educational Pnyehology tad Guidanoc,
Fbrkam: Grudnnxo School of Eunnnitio: and Social Salamect,

luv York, $.Y. 10003.
Donr

Lillltn.

I ﬁbula be delight-d to discuss the "drug quaation” with
the ntudnntl‘at Yodhivl.
‘

,

It

in becoming evidnnt thus tbs lnrge s¢nle edun‘tionnl
procrnns 1n youngnr and ravage: grads: Q30 now‘bosinnin; to
report that thty aﬁilulnte oxplorntton by students, and
rathcr than reduce the incidance of drug testing. tend to
inerense 1t. Anncdntully, this tundnnuy 1: en¢oula¢cd by the
an. of format drug uddieta who tend to glnnorise their earlier
life. I vauld be glad to mast with your student: and vuuld
try to than: on what v3 know dbout drug: thunnolvnt, but
concluding that the luau. 1! net the pharmacOIOgy of the drugs
and their dangers. bu; rathnr the tacial issuns of why vc
encourage our tavnrito drugs (alcohol and nicotinc) and
aixeourlge some.

I shall be away u good part of Janunry, but am quito
free in derunry. Call a. at hams any evening, or at Stony
Brook during the any (hhh~2hh7, arts code 516).
my

best regards.
Sineorcly yours,

ﬂux Fink, M.D.

Professor of Psychiatry
HF/id

_

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                    <text>E

,3

g

April 28.

1970

Dr. Alejandro Zaffaroni
3401

Hillview

Avenue

Stanforﬁ Industrial Park
Palo Alto, California 94304
Dear Dr.

zaffaroni,

we are faced with a difficult drug dolivery problem, an&amp;
in reading ﬁrug Research Reports, read of the formation of A123 Corporation,
with its focus on drug delivery prohlems. I am writing to enquire whether
Alma can assist us in too following problem.

Naloxono is a spocific opiate antagonist. which we have
found useful in treating Opiate dependence (01in. Fﬁarmaool. Therap., 9:

563,577, 1%58). Go oral administration. naloxone is either rapidly
destroyed or poorly absorbed, for large cases (3.0 Cms/day) are required
to achieve antagonism to heroin for 24 hours. a minimum for therapeutic
usefulness. 0n parenteral administration, 0.6 to 1.2 mg/B hours are
needed to maintain effective antagonism.
ﬁalexone is produced from tocbcinc, a prosctibed drug,
and producing supplies for oral use is impossible. In our discussions,
we have focussed on parenteral administration. and considered the
development of a long acting parenteral form, possibly in a silostic
type vehicle. We proposed such a development to the usual research
funding agencies and have received sufficient initial support to under?

takc feasibility

trials.

If A123 is intorostcd, I would appreciate the opportunity
with
meet
to
you. I plan to be in San Francisco for National meetings
May 9w13 and can be reached at the Hilton Hotel or in ﬂew York (212~369 7900).
I look forward to hearing from you.
Sincerely yours,

mf/

cc: Prof. A.

Max Fink, 14.9.
Professor of Psychiatry
Director, Division of Biological
Psychiatry
vi.

Freedman

�</text>
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"’Ir‘aﬂe‘vwr-«n‘w,"we...

G -‘-4- «mw... W.

,

.7.

————......

m

ww—

7

V

“ﬁrm

«mam-Y

,

in“...

June 1, 1970
Dr. Chris Zarafonetia, M.D.
Univ. Michigan Medical Center

Department of Postgraduate Medicine
Arbor, Michigan 48104

Ann

Dear Chrie,
Thank you verv much for your kind invitation to participate
in the International Centerence on Drug Abuse in November, 1970 at
An Arbor. I am pleased to accept and look forward to the symposium.

the format of the suggested program, I believe you
role of the narcotic antagonists in the
treatment of opiate dependence, particularly in the treatment of juvenile
abusers of opiates. As a suggested title, I would offer Treatment of'
Opiate Dependence by Narcotic Antagonists or the more general title,
Opiate Antagonists and Heroin Dependence.
From

would with a discussion of the

by
M.

In this presentation, the final report will be c0*authored
associates, Drs. Alfred M. Freedman, Richard Resnick and Arthur
Zeke, all of the Department of Psychiatry of this college.
my

Again,

my

thanks for your kind

invitation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

,.wm

-..v~—.»~an-nmv-

�</text>
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                    <text>ii

11

-m"-AW-»~N_J-

mmw

v

-

r
-.

v'm.r‘v"v'wnwmﬁ‘5rvrﬂ

November 30, 1970
'1
s

Dr. Chris

Zerafonetis,

M.D.

University of Michigan Medical Center
Department of Postgraduate Medicine

Ann

Arbor, Michigan 48104

Dear Chris,

that

I very much enjoyed the sessions in Ann Arbor, and regret
I was unable to remain the full week. I look forward to

the publication of the Proceedings.

Enclosed is a draft copy of my report, "A Rational Therapy
of Opiate Dependence: Narcotic Antagonists”, for your consideration
for the volume.
The unusual interest in methadone surprised me.
practitioners are accepting methadone maintenance as

Many

a quick

cure of the opiate addiction problem. It is a facile solution,
but one which promises much more than it can deliver. But in
our experience, it merely exaggerates the problem and delays
any definitive solution. With all their limitations, the
antagonists provide a possible "real" solution.
I trust the report will be acceptable, and that any
summaries or overviews may reflect the dilemma and its doubts

that trouble us.
Again,
meeting.

my

congratulations on the organization of a fine
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>Br. Chris Zarafonetio
University of Michigan
Ann Arbor, Michigan

January 24, 1971

Dear Chris,

It was a pleasure to read the many fine recommendations
for candidates Get the Oscar Hunter Memorial Award in Therapeutics.
My two sets of evaluations are enclosed.
As I found it difficult to select among
groups of candidates,
I scored them two ways: an approximate ranking within
groups, and then
averaged the number for each group. If the scores are to be summed
across raters, I would suggest that the better estimate of my ranking
is to be found in the number within the brackets.

I truer these are helpful.
Sincerely yours,
Max

Fink, v.9.

Professor of Psychiatry
mf/

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                    <text>.uu-u.—...umnn

y.‘r n

w

'7’,“ mm

5.-mm awn-i'h-vn- mny

.

-

,

.

,

-v.w. '- .7

.

mummy-:11v-wvw

M

rv-w—wwr-w-

a. r’uwm'vvir'vm‘nnwhurnﬁmﬁ- r—m-u
.‘

m; ~ w

-

v-vn-n-w‘w-

December 28. l967

8r. Chris J.

D.

Simpson Memorial

Zarafonetis

Institute

University of Michigan

Ann

Arbor, Michigan 43l04

Dear 3r. Zarafonetis:

Enclosed is an abstract ”Clinical Antidepressant Activity
of the narcotic Antagonist, chlazocine" for your consideration
for the forthcoming meetings of the American Therapeutic Society.
If this presentation is accepted, I will plan to present our

observations.
He

would

prefer presenting this data at the

or the first day in San Francisco since
at the Society of Eiological Psychiatry
Thank you

Honolulu Session,

I have another connittment
on June 14, in Washington,

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
EDC.

0.6.

’K’M‘n-w

v-w—u

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                    <text>September 14. 1964

Dr. N. Zenoutnikov

c/o Rotisset Hospital

horisset
New

South Wales

Australia

Dear Dr. Zenousnikov:

In evaluating your letter of August 25, I find that the second
page of your statutory daolaration'is missing; It is difficult,
therefore. to make s satisfactory evaluation of your experience

with relation to the various opportunities both at this institute
and in other institutions of the Division of Mental Diseases of
the State of Missouri.
As

tentative showers to your specific questions, subject to re-

view when

that

I hero seen the

second page of your record.

it

appears

requirements of an applicant
for residency. The State of Missouri does not have a Diploma of
Psychological Modicine since this certificate is unknown in the
United States. The equivalent is a certificate from the American
Modical Association Specialty Board, the American Board of Psychiatry
'and Rourology. qualification in psychiatry from that board requires
three years of accredited residency training and two years of prsc~
tics in psychiatry. Both the three years of accredited training and
tho two years of practice are available within the Missouri Institute
of Psychiatry program.
you

satisfy the age

and

SCENE

Hith regard to candidates who alaesdy hold the D.P.H., they tend to
fall into two groups. Those who wish to qualify for a board certifioation in the United Statos find that the D.P.M. has no standing be~
tors the American board and era requirod_to tsko a full three year
residency and two years of practice. On the other hand, many institutions within the United States and a number within the Division of
Mental Diseases of the State of Miosouri will accept a D.P.M. as a
qualification for s gsychistrist ll position. This position permits
the candidate to assume responsibility for clinical programs within
one of the institutions and further training is not required.
Modical licensure within the State of Missouri

is at

two

levels. For

are not citizens, and who are appointed to an institut~
ion of the Division of Montal Diseases, temporary license can be

individuals

who

�Dr. N. Zomouznikov
9~lé~64

Page Too

scoured upon application by the candidate and approval by the
Dirootor of the Division of Montol Diseases. Snob licenauro is
usually limited to a period of five years, at the and of which

time most oandidotoo have quolitiod for Amorioan citizenship.
that time, they booomo eligible for the examinations of the
Stoto of Hioooori and upon satisfactory completion of that oxamina~
tion can toooivu an unqualified license to praotioe within the

At

state

0

interested in participating in tho programs of
stillMbntal
of
Diseases. either as a resident or as a staff
Division
the
number, I ohnll be pleased to receive a copy of your sooond page, a
small photograph, and the names oi two toferoeo to whom I may write
for further information.

If

you are

Thonk you vary much

for your inquiry.
Sincerely yours,
Max

Mlljb

Fink,

M. D.

�</text>
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                  <elementText elementTextId="102643">
                    <text>October 8. 1968
Mr. Edmund Zerkin
PHAHTASTICA

Beloit, Wisconsin

Dear Mr. Zerkin,
We have reviewed the request by Mr. Gemege for the
submission of an original report for the new journal, PHAHTASTICA,
and zigz‘pleased that my associates agree to send you such a report
within the next few months. The report will detail the central
nervous system effects of a variety of hallucinogene, and will
summarize the data presented in a review article I wrﬁte last
year entitled, 'Neurophyaiology of Phenteetica- EEG and Behavioral
Beletione in Men'.

as the

this

It wee striking to us that you selected the same name
title for 1 your journal. An I correct in assuming you obtained

from Levin

The report will probably be 20~25 typewritten pages,
double spaced with 2~3 tables and citation: sufficient to acquaint
the interested reader with the sources used. The major emphasis
will he on our own work.

have asked a young associate of our etetf, Mr. Peter
Irwin, to rewrite the report focueoed on the students who may represent
the major audience of the journal. we would be pleased, of course,
if the report were included in the inaugural issue.
We

reply.

I trust this is agreeable

and

anticipate your favorable
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                  <elementText elementTextId="100925">
                    <text>July

Wt

Isadm 3. Mass.

22 , 1963

H. D.

2502
Awmc
Richmond 20, Virﬁnia

Dear Isadore:

enmmnnlkrmmtlwasmvingmdwmldbe

Manymmtm

preoccupied in doveloping this oeutar,

IMdtoKuuwth.

program.

I sent all the material that

isinlmtym's
mustafalltmmibitm
Wm,andﬁocmn,

Inadditimmm.

W.

us had 81mm. Samar-aw and Teehniaal Sales Cor-pantie). I don't

mean

any others.

Earlyinnymmrloonmctedmnyofmmmuﬂcal

heme: and mylmm

mifmly nemtiva.

mica

The mly new
that I MIG consider are MinneapolisHawwell. Gama]. Pmciaim, Manx. and possibly me two

mics -

IBM

Wm

and control Data.

man): you very men

for ymr‘kind wishes.
‘

Sinmmly yours,

Max

Fink,

Dim

14er

H. D.

�</text>
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                    <text>April 3.

1969

Dr. Isadore Samuel Zfass
Chairman, Commercial Exhibits
2502 Monument Avenue
Richmond, Vigginie

Isadore,

Dear

Surely. the computer representatives should be
I would suggest Bigital Equipment Corporation.
make the PDP series of computers, Scientific Data Systems
may be interested in getting into this field, and 13%.

represented.

who
who

It

may

be too

late for

many

of these companies. but

perhaps something can be done by phone.

the

My
DEC

interaction has been with IBM only and I do not know
or $85 representatives. Since both instruments are

probably represented

at the Brain Research Institute, perhaps

a member of the organization committee could make the initial
representation. I will be glad to call IBMVand make inquiries

here.

availability of the exhibit hall
at the earliest, I am concerned that this
will make the demonstration very difficult. I will inquire
of IBM as to the feasibility of this schedule and let you know.
with regard to the

on September 12

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 6, 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood

Englewood,

New

Hospital Association
Jersey 0763l

Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward 12. If you can
arrive at 9:30 am, I will arrange for a tour prior to the
conference. From 12:00 to 1:00 we will arrange for one of the
nurses who would explain the nursing aspects of patient's care

in these units.

If you tell us the number of persons coming, I will ask to
arrange for you to have lunch and after this you will meet with
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o‘clock.
If time is short,
then we would suggest that you not attend the conference and we
can arrange for discussions from 9:30 to l2:00.
I

will arrange for our psychiatric assistants to be with
will provide a continuing commentary.

you throughout the day and they

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital

if

Association sencitwo checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>June 6. 1968

Ziering, R.N.
Psychiatric Instructor

Miss Hannah

The Englewood Hospital Association
Englewood. New Jersey 0763l
Dear Miss Ziering:
would be pleased to have you and your students visit us
and because Thursday is the best day for part of the demonstration,
I suggest you come on June 27 and August 8.
We

The core demonstration would be a case conference held on
Thursday from 10:30 am to 12:00 noon on ward l2. If you can
arrive at 9:30 am. I will arrange for a tour prior to the
conference. From 12:00 to l:00 we will arrange for one of the
nurses who would eXplain the nursing aspects of patient's care

in these units.

tell us the number of persons coming. I will aSk to
for
to have lunch and after this you will meet with
you
arrange
one of our physicians and a member of the rehabilitation team.
A good overview can be obtained by 3 o'clock.
If time is short,
If

you

then we would suggest that you not attend the conference and
can arrange for discussions from 9:30 to l2:00.

we

I will arrange for our psychiatric assistants to be with
you throughout the day and they will provide a continuing conmentary.

it

As I discussed with you on the phone,
would be most helpful
I could provide the psychiatric assistants with an honorarium
for their time and I would suggest that the Englewood Hospital
Association sen&lt;1two checks in the amount of $50.00 each in the
name of Manuel Rodriguez and Albert Hassan. Please send the checks

if

to

my

office.

Please confirm

if

the dates and times are satisfactory.
Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

�</text>
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            <description>An account of the resource</description>
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                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <description>A language of the resource</description>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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            <description>An entity responsible for making contributions to the resource</description>
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        <name>Correspondence</name>
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