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                    <text>mevrn~

vvw-

unusu—

Marco 31. 1969
Mr. T. Bloomer~
.

“
i

“—1,

v

.7

"um“

v.1;

n

“gun.

.mv

‘q‘l-«Iw

IBM

‘

475 Northern Bivd.
Great Neck. New York

Dear Mr. Bioomer:

discussed with you on Tuesday, we have been dis»
amount of time that our IBM 1800 has been
vdown.
In comparison with our previous experience with IBM
equipment and in view of the reputation of this instrument,
I wouid appreciate your review of the stabiiity of our equipment
and the program for updating and the probiems in software
support.
As I

satisfied with the

Thank you

mumvrmr-

,qn.

for your cooperation.
Sincerely yours;

“ﬂu—r..-

ﬂax Fink, H.D.

Professor of Psychiatry

MF

:kp

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                    <text>731-8031

11 Decamber 1973

Dr. Dinahaw R. Doongaji

3rd Floor
Bombay Mutual Terrace
Sandburst Bridge
Bombay 7
INDIA

Dear

Sir:

International Association for Psychiatric Research,
Inc., is not a membership society. The Association supports
psychiatric research through grants and awards for fellowships.
The

Thank you

for your inquiry.
Sincerely yours,
Max

MF/cis

Fink,

M.D.

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                    <text>7383~74253

16 Oetoﬁur 1973

J. l
104

A. Churchill
Glouccutcr Place

London

In:

m “E
Our

2.0. 036a2. August

A, 1973

mum:
Plnaso apprtaa In of tha status of tho abovu 0:40: for thrao

(I) copiu a!

man:

ville-Groom.

Wm“

11:

6111113;

vacuum by x.

Gran-

nopctully, Eh. order Ihauld ha on it. any to Eh. Bipartncuc
of Paynhutry. I! not. plan media in; 1:5 :3de for in»

amazon“. purge-u this

smart.

Thank you.

Simauly,

rm.
Profuse:
tux

I#1.

14.0.

of Psychiatry

�</text>
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                    <text>l

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1975

Kbnneth Elam. Ph.D.

Editor

‘

q-wmwv

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‘
‘

.2‘

am

nmvrmum:7r

ancrtunnt of Pharmscology
_Tho‘Uh1vuraity of $.23:
Bhalth Science cantor at San Antonio
7703 Floyd Curl Drivu
San Antonio, Than: 7828h
‘

Dear Dr. Baum,
Thank youffbr

the invitation to participate in the

volunc, “Social Meaning of Drugs."
mitmnnin are too

great to «lieu

me

I rogret that my prosent cam~
to give this qnhation preper

attention.
As

an

alternate, you,m:y wish to invite Alfred

,Frecdman. M.D., of tho

New

York Mbdical 0011033.

He 13

K.

unusually

sophisticated in the issuah of tha social and clinical usas of
drugs.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

.1 :

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.

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                    <text>'

nyne-wwjiw’wr'”?ﬂﬂ

p.

We 1,

1962

Dr. Arnold Blmberg

Hillside Hospital
0. B“ 38

Po

'

Glen Oaks,

New

York

Deer Arnold:

It has been sonar weeks about

opportunity to talk

emetimos

it

seems

research problems.

years .. since

The work here

is

have bed en
going very well,

we

for tin last few weeks I have had w first opportunity to work with pstients
in the new setting. I me writing because I believe we here as metal opportunity
to oerry out a study which may be of interest to you. As I review the oherte or
sub of my patients, I find that they have been on psychotropic medication for
months, and in some instances, for years. Today I saw a men who hes been
receiving 3 vesioty of phenothissines since 1956 without a significant period
without medication. As I recollect, you were quite oonosmod some years ago
about the longutorm effects of such mdioation. I do have the opportunity to
take those patients off medication, and this will be data. None or the patients
have had an adequate work-up before hand so that it would be impossible to nuke
any statement regarding s "shame" in any medical measures. However, if we
simply survey 9. large umber of subjects we shmld be able to make s aux-mine.
tion of mother or not certain blood constituents or functions are "abnormal"
for the ego.
end

Home my questions. is Gould first ask for a white count, differential
hemoglobin and other of the blood elements. Also, s. "liver profile". These
ere the routine studies which oould be dorm. However; I an sonoemed thet
ﬁe were to take snob measures only, then we would probably gain very little
information. Are were some laboratory studies, albeit not routine, that you
or Hemnight suggest tomb such a study worthwhile?

it

As you sen
it is e lot of work. I move patients to the wards
gun,
we bed our dedisetion on the 22nd. That went very well
in lid-Ootober, end
end I believe that us have s. pest deal of support, not only fronthe Governor
end the politioiens, but the wblio es all. W staff is growing end if ell
the candidates who hen agreed to ems, some betmen new end next Jen, I
should heme e very 1well qualified experimental group. I new Just let it
be known thet I en interested in the essistenoe or s full-tine plosioien for
our resemh wows. The hospital bee a large audios}. start and tor relationship to thee ms hes been quite good. I hope, on one of your visits to the

�mow-It, that you will have tho oooasion to visit with no and by then I
should be able to show you laboratories that my be a. happy outgrowth
of our Hillside experiences.
The

children are quite! happy in whool

and have made Manda very
very satisfactory and I an plowed with mob that.
I have found in St. Louis. As one can expect, the most difficult part of
no): a move is the loss or Moms.

quickly.

Our home

is

m

013 last. note. I have had
opportuniw to go over the Hillsido
data on a few occasions. I 1mm: that Mu ham written to tho computing
cantor of. Washington University roqmoting sons
in the analyses,
andIbope that thesawillbo 1301
.
1%

best. regards

to Barbara

and

“31m

yourself.
Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

Max

MFsaw

Plane address oomopondomo to:

Fink,

Director

,

51.00

M.

n.

Arsenal Sol, St. Louis 39, Missouri

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>Fobruory 25, 1964

Dr. Arnold Slumbetg

Hillside ﬁoopitol
P. 0. Box 38

Glon Oaks, Nov York
Door Arnold:

I on toting tho liborty of nucleolus the provisional protoool

from Dave Engelhordt. which not given to to for my comments.
I know Dr. Edolotoin and ho is o oompotont vorkot. I hopo
that Dave and you con got togethot, as this may be a fruitful
project on whioh you can collaborate.
a copy of our annual report. During
have had oomo opportunity to look at oy
own work. and 1 how: been excited by too pinto: of data. In
a diocrininoto function analyoio which I racontly carried out,
the EEG critorio discriminated the schizophrenic and tho de~
pros-lye groopo. In looking at the individual potionto. tho
ditforoaoo between the group: was created largely by the
”broin—donogod" ooh1309hronloo. I have writton to Max obout
this and ho has sent no tone of tho original E363. Torso Itil
and I will be going over than in tho noxt few days.

I an plellad to enclose
the past few wank.

l

Anothor analysis in on

my

dook

this minute. It in a canonical

oortolotion of 23 of the bohovior vatiobloo and the five EEG
votinbloo. Ho ton tho oortolation for tho dillorouco soot.(poot uinoo pro; for each drug and for tho total population.
Unfortunately. non. of tho correlations appear to ho signifin
cant. u. must chock our progtnn. however, as thio.is tho firot
cononioll that we hovo run.
Tho EEG oupplooont

is in its final

appoor by tho oiddlo of the your.

pogo proof

torn,

and should

�L

Dr. Arnold Bluubsrg

2-25~64
Pugs TWO

Msttha and I sts planning to so to Isrssl this suunsr. as I will
be in England for tbs CIR? nasttngs. I rseollsc: your
trip and
your picauxss quits clssrly. I hsvs s fsv scqustntsncss that I
may visit. but chore Is an «us who is in ch. professional world
who alght asks it easy for us to look in on the
major psychiatric
centers. Do you have say suggestions when I may contact?
By

bus: rsssrﬁs to Esrbsts.

Slncsrsly yours,

“It Fink, “on 0
Director
MP/jb
EEC s

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                    <text>February 25, 1964

Dr. Arnold Blumberg

Hilloido ﬁospltal
Po 0. BO! 33

Glen Oaks. Now York
Dear Arnold:
on taking the liberty of cnolonlng tho provisional protocol
from nova Engclhordt. which won given to no for my communes.
I know Dr. Edclsccln and he is a component workor. I hope
that Dave and you can got together. no this may be a fruitful
projact on which you com collaborate;

I

.

I

am pleased to enclose a copy of our annual report. During
the past few weak: I have had lama opportunity to look at my
own work. and I hava boon axcltod by two places of data. In
a discriminate function analysis which I rccontly carried out.
the EEG criteria dlncrlmlnated the achlsophronlo and tho dopteunlvo groupl. In looking at the individual patlontn, tho
difforunoo botwoon the group: was crusted largoly by tho
"brain~daongod” schizophrenics. I have written to you about
this and ho hos aunt no some of the orlglnnl EEGI. Turau 1:11
and I will be going over than in tho moat few days.

Another analysis

is

on my dank

this minute. 'It 1: a canonical

of the bohavlor variable! and the Elva EEG
correlation of
Ho
vorlnhlol.
ran tho correlation for the differenca snort:
(post minus prol|£or each drug and for tho total papulatlon.
Unfortunately. non: of the correlations appear to be :lgnliiw
cant. Ho must chock our program. howuvor. as thla lo the first
canonical that on huvo run.
23

Tho EEG supplonont

is in its final

appear by the middlo of the your.

pogo proof form, and should

�Dr. Arnold Blunborg
2-25-64

Page Two

Mirth: and I are planning to so to tarsal this ounmor, as I will

be in Englané for tho 613? amazingu. I rocolloct your trip and
your piotutoo quite clearly. I havo a fan acquaintances that I
may visit, but thorn in no one who 1: 1n the profoootonol world
who might makc it «any for ms to look in on tho major psychiatric
contort. Do you have any nuggoottono whom I may contact?{
Hy

hoot rogards to Barbara.

Sincerely yoora,
H‘x Fink, HOD.

Director
HF/jb
E1130

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                    <text>.,...«(,‘
'1‘

,v

r

April 9,

(fiat darl'id at" i.

196$

Dr. Arnold Blunbarg

Rillnldo Kolpttal
Po

0.

BOX

Clan Data,

38

New

York

Baa: Arnold:

just luau your revert 1n the Jourhnl of Foychiatric Rananrch.
trying to keep abreast of the reporto from our Hillzida
ctudy, I would appreciate a few reprints of this report, ané any
I

A;

haw.

I

am

arbor: thgt

I

am

find

you may have

in

prtil.

just returning Max's report

on 1wipram1ne

disorganixattou,

and

of tha analynes very 1ht¢r¢8c1n3. Can ¥$WQNﬂkﬁ anything
of the change: of blooﬁ preccura in those pattanta?
some

Sincerely yours,
MK Fink.

Director
Hrljb

MOD.

k.
A
-‘ 3‘

�</text>
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                    <text>April 9,

1964

Dr. Arnold Blunbntg

ﬁtllsidc ﬂoupital

P. 0. BOX 38
Gina Data, Raw York
Dear Arnold:

of Psychiatria Relattch.
I have just seen your report inofthetheJournal
rapOtta from our Hillatdo
A: I am trying to keep abreast
and toy
study, I would :ppractaue a few raprintl of this report,
othnra

:htt

you may have

in precl.

and
report on 1m1prnm1neCandisorganization,
gnkamake anything
find some of the analyaes very intcraoting.
of thc change: of bloou ptessura in these patients?

I In just rotnrning

Max’s

Sincotoly yours,
Fink,
Director

Max

Niljb

M.D.

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                    <text>June 7, 1965

Dr. Arnold G. Slumber-g

Hillside Hospital

P. O. Box 38
Glen Oaks. New York
Dear Arnold:
.

,

Daring the pest few months we have been troubled by extensive

altemtime in weight in our patients when their mdicetim was
terminated, or when mdicatim was materted. In reviewing our
experiences, I note that the wig“: changes were not sigmificmt.
Yet I
to recall that you dctailed this experience my! may

m

have reviewed the

liter-em.

Did you? If so, I would appreciate any information which may
be of assistance to one of my young associates who is now moor»
taking a review of the problem and perhaps will try to smrize
his experiences. the thing we have noted, is that
the weight changes
are not related to the behevioml dunges, but appear to be dependent
on the ctxengea in drug region: rather than any behavioral cmcomitmt.
This he: become clemr because we have a group of patients in whom
chug patterns have been dunged on a sdxeduled basis independent of
any behavioral change.

An you planting to

go

th the mmion? I believe that I will

beinNewYozketthettim mdshellnytomeke matevehing
meeting.
Hyvbest regards.

Sinoemly yours,
Fink, H. D.
Professor of Psychiatry

Mex

HP:kp

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                    <text>$33
June 7, 1965

Dr. Arnold 9.

31mm

Hillside Hospital

P. 0. Box 88
Glen Oaks, New York

Bar Amold:

wt
altamtims in weight in our patients when their medication was
madicatim was matured. In mviowing our
terminated, 01'
note
that the wig“: changes mm not simificmt.
I
experiences,
the

m

few

mum

we have been

tmubled

by extensive

Yetlammmeallthatyoudetailadthisexperiomemgimy
have reviewed the

Didyou?

11mm.

Ifso,Iwou1dappmciatemyinfomtimwhidxmy

beofmistmmtoomofnyyomgassocimswhoisnwmdwtakingamviowofthapmblmmdpemapswﬂltrytoswiu
unthingmhmmted,isthatthem1ghtdmgea
ammtmutodtothebehaviomldxm,butappeartobedcpendent
mthcchmguindmgmgim mﬁnrmmmy behavioral concomitant.
mishmbomclomrbemcmhawamofpatimtsinm
Wpattemhmmmmgodmasdwmledbasisindepmdmtof

WWW.

mybetuviomldamge.

Aruymplmingtogothﬂmmmim? Ibelimtkmtlwill
beinNewYorkatﬁuttimemdshauuytomakemtevening
nesting.

Hybastmgarda.
Sincamly youm ,
Max

Fink,

H. D.

Professor of Psychiatry

Hf’:kp

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                    <text>'EIW,-v1'vv‘.wr&lt;r

A

March 28. l968

Dr. Arnold G. Blumberg
m.

.

mm.

47

1'9!

Department of Medicine

Hillside Hospital

P. 0. Box 39
Glen Oaks, New York

&lt;2

’IIW'Dzv-gyl‘

Dear Arnold,

to read of the death of your mother. It
years since I last spoke to her but I
few
remember from the
visits to your home during our early
days on Long Island. Please accept my sympathy.

I was saddened
has been many, many

the unusual opportunity to discuss the report
“Enhancement of Imipramine Antidepressant Activity by Thyroid
Hormone“ at the forthcoming meeting of the APA. I know that
you could do this much better than I, and am taking the
sent to me by Dr. Prange,
liberty of enclosing the pre-print few
minutes to read it and
have
would
a
in the hope that you
to cement.
I have

thyroid extract been used to
convulsive therapy?
Has

alter the resoonse to

Have you,

or anyone else, attempted to confirm Dr. Prange's

Thank you

for your help.

suggestion?

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>n.

mmwmuw—mnww‘

,
,

October 14, 1968
Dr. Haro1d B1umberg
Endo Laboratories
1000 Stewart
Garden City. New York
Dear Dr. B1umborg:
Enc1osed are cooies of ana1ysos by Dr. Schwarzkopf of
of heroin in Novembor 1967 and again in October
1968. You W111 note that the November samp1e was quite pure
and the October samo1o was the one which I discussed with

a samp1e

you.

I wi11 be very gratefu1 if you wi11 arrange to provide
with 10 grams of pure heroin for our research studies for
the remainder of 1969. Mr. John Haber of the Fodera1 Bureau
of Narcotics expressed the w111ingness to de1iver as much
heroin, simi1ar to that ana1yzed by Dr. Schwarzkopf on
October 7, as may be necessary to produce either 10 grams. or
more than that amount. to permit the Bureau to have some pure
me

supp1ies for others.

Thank you very much

for your cooperation.
Sincoro1y yours.

Fink. M.D.
Professor of Psychiatry

Max

Mszp

"v.

�</text>
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Fibrunry 9th. 1973
Exam.
1&amp;05

Eye

8t.. x.w.,

Whininston, D.G. 20537.

Gentlumcn.
‘

I bald the fbllawing
211732103

(Exp. 9/30/73) 4

moehsss (Exp.9/30/73)
PFOGSOSE?

5

(EXP.

BEBE

registrations:

2.3; h, 5 - haotitioner

~ 1

'_,

Researchin-

9/39/73) » l‘~ Importer

These are oparational at the ﬂaw York Mbdiaal Colltge
Knit 102nd Streat, Kev York City. During 1973 I nu

at

transferring aw operation to the State university of Raw Yark
at stony Brook. with a syecific laboratory at the V.A. anpitul
at Nbrthyort. The progrcn of work will include studial or
opintcl and cunndbis and will rcquiro continued importation
of nub-taneea. This Hark in obtained under RINK contract; to
this univnraity. I u: writing to requout appliention forms
for registration certifieatos as a runearahor. antagory 1;
import-r. eutegery 1; and practitioner, category 2. 3, h, 3.
During 1973 I will cantinue on pgrt~t1mm basis at the
new York medical College and tha present registration: will
continua that. until thqy ara transferred to ‘nothcr number of
the atxrt by their uppliention.
Binnoraly years.

Mt: Fink. M.D.
Prothaaor of Psychiatry

grit:

ﬁne.

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Craig

D.

Darrell,

M.D.

Chairman, Sectim of Biological
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'1?» New York Madam! of
2 East 63rd Street
New York. N. Y. 10021

Sam

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Scimmtingmhprﬂ
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M. D.

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'BOARD OF VETERAN'S APPEALS

Washington, D.C.

FROM:

Fink. “.0.
Arieigh Road

Max

39

Grunt Neck,

Subject:

New

066—18-2080
York

Consultation Fee

For consuTtat1on report} dated January 6, 1969.
Tomkin Buckles
concerning
0116
C

18 056 379

$100.00

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                    <text>a

”w".

A

November 29, 1968
Mr. Alden Bober

Acting Chief Chemist
U. 8. Customs Lab.
103 3. Gay Street

Baltimore, Maryland 21202

.n~p—rvw-,-

«rug:

:swwr-n-rn

-«.-

F1."

ww..«.r—

n
.

"‘;P'.:—c":n.'aﬂmv-"-

a-wc

Wr

v-rwafP-:WWW';rm-ﬂ“

ANW~\5,A~

wmrl

v.

Dear Mr. Bober:

"

)4»

three samples, individually labeled, of

presumed marijuana substances. Ibo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIHH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>»

“urn-«r

x-

r

November 29, 1968

uma-w-vmx—w-wwwwa

mm»

'"v'grwamr-mnw

Mr. Alden Bober

Acting Chief Chemist
U. 5. Customs Lab.
103 S. Gay

Street

Baltimore, Maryland 21202
Dear Mr. Bober:

Attached are three samples, individually labeled, of

presumed marijuana substances. lVo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIMH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="106906">
                    <text>March 28 , 1971;

Jonathan 0. Cole, M.D.
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are some of the forms that we are now using
to maintain alertness in our subjects and to assess changes in
behavior during our phasewI EEG classification trials. Our
principal method of assessing behavioral change is to ask the
subjects to open their eyes every h minute and 20 seconds (and‘
to keep eyes open for ho seconds), asking: "Do you feel any
change ?" Alternate inquiries add,
"On

a scale of

—6

to +6, would you rate any change in

your state of alertness (awareness)?" The subjects are told at
the onset of the experiment that their present state is to be
rated as '0’.

The symptom questionnaire is used befbre, at the mid~point
of the experiment, and after the experiment is over. Examiner asks
and notes responses.

a self rating completed by the subject before the
experiment, at the mid—point, and at the end. Rating is either by
hand or by computer program.
CMS:

Irwin inquiry: an open—ended sheet to maintain a running log
of the subject‘s behavior, answers to questions, movements, etc. In
the left columns, time is noted; 'as' is the alertness score given
by the subject;'bz' is the number of times a hand—held buzzer was
released during the previous time period; and '123’ reflects another
scoring estimate used by us in examining the effects of benzodiaz—
epines, and not relevant for your work. Page 2 of the inquiry is
completed at the end of the experiment.
From

this range of behavioral inquiries,

we

believe

we

have teased out some aspects of the subtle behavioral changes in
our subjects when we have used threshold doses of novel and established
compounds.

I

trust these

comments

are helpftl.

Good

luck

!

Sincerely yours,
Max

Fink, Mb.

�</text>
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              <elementText elementTextId="59567">
                <text>1974 </text>
              </elementText>
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              <elementText elementTextId="59568">
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              <elementText elementTextId="59573">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102531">
                    <text>May

2. 1968

Dr. Daniel P. Bobon'

Assistant

A

L‘Universite
l4

Quai de Rome,

Liege, Belgium

Dear Dr. Bobon:
my

Enclosed are representative reprints of the studies from
laboratories, as well as two preprints of work that may be

of particular interest to you.

It was kind of you to consider an invitation for your
forthcoming roundtable in Belgium and I trust that these
reports will give
In the efent

you an idea of our work.

that

you consider coming to the United States
fellowship, I would suggest that you write
approximately nine months in advance, indicating the probable
date of inception and enclosing a copy of your curriculum vitae.

for

a research

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

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                    <text>Wm

~241¥|m¢V~n .w

'Wmivpni.1. n

.

-»--.»;

~

rum.» gum—w»-

r.r),v (”yam-r- .

,

.n.»

.-.,.-. .«.~,.ym.. 4,77,“

_.,.,.mwnr,mwr

ng

.../

.

‘

August 15 . 1969
Dr. Daniel P. Bobon
University of Liege
Clinique Psychiatrique
Rue Saint-Laurent, 58
Liege. Belgium
Dear Dr. Bobon:

I am writing in reply to your letter of July 16 and I am
pleased to have you spend a month in our Department in the spring
of 1970. It has been my experience that observers who wish to
understand our methods find them confusing until they accept the
responsibility for a specific study and attempt to carry out the
steps necessary' to write a protocol, collect and analyse the data
and write a summary. Some visitors have joined my Department for
a few days and this has given them sufficient opportunity to take
back with them an overview of our methods and facilities and attitudes.
While I would welcome you for a month, I must caution you that
this time is long as an observer and much too short as a participant.

of

Unfortunately,

we do

not have funds available for the support
on an annual basis. In the event that

visiting scientists except

you are interested in coming for a year,
on your behalf to a number of agencies.

I

visit,

I can nuke an application

to consider an application for e year’s
as thia‘will be the best for your program.

would urge you

For funds for a shorter period may I suggest you apply to
or WHO. Scientists have been sent from Europe to laboratories,
including my own, by WHO. Applications are made by the European
scientist and the roquiresent for us is to welcome them.

UNESCO

My

best regards.
Sincerely yours.
’4‘! Fink.

MOD.

Professor of Psychiatry

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                    <text>October 13, 1969
Dr. Daniel P. Bobon

University of Liege
Clinique Psychiatrique
Rue Saint-Laurent, 58
Liege, Belgium

Dear Dr. Bobon:

It

gives me great pleasure to invite you to participate
in the programs of the Division of Biological Psychiatry
of this Department of Psychiatry in 1970. I look forwtrd
to having you participate in the work of the Division,

particularly in our

EEG

analytic projects.

The best time to join the Department would be during
the month of April, up to May 8, or from May 16 to mid-June.
May 8~16 is allocated to meetings of the American Psychiatric
Association and Society of Biological Psychiatry, both of
which meet in San Francisco this year.
I look ferward

to having yougbin in the

Department in the spring.

work of

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

this

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                    <text>Eecomber 12, 1969
Dr. Daniel P. Bobcat

Cliniqne Psychiatrique
University of Liege
Saint—Laurmnt, 58
8-4000 Liege, Belgium
Rue

Dear Dr. Bobon:

to your letter of December 14, the dates
satisfactory as any other during that
time. I am pleased that you are going to visit Professor
Itil. April is a beautiful time in St. Louis.
In response

April 13~25, are as

Sincerely yours,
armv’mmv

Max
0

ﬂF:kp

A
.

w
.m—

3151-!

(rm-3.3”

minim/11v

raw—IV!“

mum—Ivar”

I
mam,

v"W“’J!'V_’!“T"‘,"-r"!’

,

Fink, %.D.

Professor of Psychiatry

«myr'h’vjﬂ‘

�</text>
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WW-.M‘_VW-_,__.WV_..W__u“WWW.Vm.__._..,_.-..,___._‘.___-w_.____t._____,-_..-_.

-7.._._..t..

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,

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December 11, 1969

"wr-

..,.,

Dr. Daniel P. Bobon

,1

Clinique Psychiatrique
University of Liege

WV

Rue Saint—Laurent, 58

Liege, Belgium

”r

Dear Dr. Bobon:

look forward to having you work with us from
April 13-25, 197G. I would be pleased to have you meet
the staff, attend conferences and become acquainted with
the projects in progress. It will also give you an
We

Tm]

'

opportunity to meet Professor Freedman and to
of the other laboratories at the College that

visit
may

you.

some

interest

College'doos not have a dormitory, so that visitors
usually stay at one of the residential hotels within 10 minutes
of the laboratory. Those are available at approximately $90/wook.
Meals may be taken, in part at the hospital, and average $6.00/week.
The

vw‘.

I look forward

“(11W)“

'WU',‘

to

welcoming you in

the time and route of
let us
necessary arrangements.
know

York.

New

arrival,

we

will

If

W‘

Sincerely yours,

“mm

W-VPVW'”

Max

Fink, M.B.

Professor of Psydhiatry

WWW”.

ffFLkp
w

3
.

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                    <text>5“wath ,w—.-rr -n.

-.—.

mvm~v~r

mum-u-

'

-

v:

.

.

'

“V"' '-W

‘

.

,

,—_mr~

W.1—,mwwww .vr~.

.

Novnnbar 12. 1970

w—x

Wwww'w‘nv-naa-

;

E

Dr. Daniel P. Bobon

Cliniquo Psychiatriqne
Univnrsity of Liege
Rue SaintvLautent, 58
Liege. Belgian
Dear Dr. Bobon:
Dr. 1:11 has raised a quastion uith regard to our uumaary
in "The Reurolcpttcl", and an I concur with his opinion. tn
writing to ask that..1f reissued, the text be corrected.
q

On

page 14, the sentence,

"It is possible..." omits the

unjor class of thn ncuroleptics (Intipsychotics) and includes
the analgesic:. The untlgcsics havo not been adequately tested
to form a class ~ but the Intipsychotics form our largest class.
are to be congratulated on presenting n fine volume,
a acnnnto of a was: intereuting convucation.
You
My

has: regards.
Stnccrely yours.
Max

Fink, M.D.

Professor of Psychiatry

Hrzkt

cc: Turan

Ma‘w‘aw'

4‘s

Vr’uif‘v

M.

1:11,

M.D.

�</text>
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                    <text>23. 1968

May

Prof. Jean Babe»
Ciiniqua Psychiatrique
Liege. 8eigiqua

'

Bear Professor Baton.

It

kind-of you to consider

was

my

participatian in the

fbrthcoming ”Interdisciplinary ﬂeet on "unrelentics” in May, 1969.
i mania be pleased ta participatn. and 109k farumrd to doing so,

subject to the vicissitudes of the prnsent restrictions

on the

use of our funds for internationli travel. as yam may have hanrd,
since March 11. 1968 we have not been permitted to use any of the
usual fund: for such tnivoi, tad wt viii have tn try to obtain
new funds from other than our ntuai sources. As this it a new
situatien far us, I an unabio ta be optimistic at the present time.

interests

I did enjoy meeting your
and by

bit futility

in

tan,

who impressed an by

war ianguage.

Ha

his

would be giensed

consider an appiicatien from him to continue his studies in our
iaborateries which are deveted primarily to studies of the effects
of psychoactive drugs on the human EEE.
Again.

my

thanks for your kind

to

invitation.
Sincereiy years.

Fink. M.D.
Professor of Psychiatry

Max

”Fl

I

�</text>
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s
E

w'zwrﬁ‘w-v—v"

.-

y-u—‘W‘me

y

March 31. 1969

Dr. Jean Bobon

Clinique Psychiatrlque
Rue

Saint—Laurent. 58

Liege, Belgium

Dear Dr. Bobon:

w",

"m.

W7

I look forward to participating in the Interdisciplinary
I am writing to confirm my planned
Heek on Neuroleptics at Liege.
at l435, SH 794.
arrival in Brussels on Sunday, May

ll,

I look forward

37...”...

to the meeting.

mm”

Sincerely yours,
Fink. M.D.
Professor of PsyCh‘atry

_Max

Hszp

�</text>
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                    <text>January
Mr.

23 , 1967

Stefan Bogen

Department of Medical Investigation

Inc.
Jersey

Hoffman LaRoche,

Nutley 10,

New

Dear Mr. Bogen:

WeareundertakingateaclﬁngprogramintheMental
Clinic for psychiatric residents , in which we would
like to make available placebo medication.
have discussed
this with your medical center representative,I Mr. Marini,
and I have been asked by Mr. 'Billig to write to
you.
Hygiene

Since Librium is a cammly used drug,
would be very
if we had a supply of the drug and placebo available
so that individual patient treatment schedules can be modified
to the patient's best interest. I would be grateful
if you
would make available a supply of 5,000
10 mg Librium
tablets,
and an equal amount of placebos.

it

helpful

.

-

Thank you

for your cooperation.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

and Clinical Director
MF:kp

�</text>
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                    <text>June 28, 1957

;
va'

1‘

\.

,mr'mram

1"...

mum.

Stefan Began
Senior Research Associate

Mr.

Departrmt of Medical Investigation

Ibffmnn-La Roche Inc.
Mrtley, New Jersey 07110
Dear Mr. Hogan:

first supply of Librium
are using this as the standard in the treatmnt of
anxiety. A copy of the present protocol is enclosed for your
infatuation.
since

We

have already gone through ﬂue

we

it

Would
be possible to provide us with an additional
supply of chloxdiazepoxide, active, 25 mg capsules to continue
this study?
Many

thanks .
Sincerely yours,

1-1

.

a
(mm-

Fink, NJ).
Professor of Psychiatry

Max

‘w

HIV-V"

mp;

1r;

."A;':‘

MF:kp

�</text>
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                    <text>May

2, 1967

Stefan Bogen
Senior Research Associate

Mr.

Department of Medical Investigation

Hoffmann-La Roche Inc.
Nutley, New Jersey 07110

Dear Mr. Bogen:
Thank you very much for the supply of Librium capsules
and placebos which have arrived and which will be most useful

in our teaching progem. Unfortunately, the supply sent was
5 and 10 mg capsules.
Since the majority of our patients have
dosages above 25 mg, we have found the 25 mg capsules most
exchange the 51:13
usefulandwemuldbegzeteful ifWecould
capsules for an equal number of 25 mg capsules.
We will maintain an inventory of the medication to present
to you and the rm. Records of disposition of these medications
will be maintained in the Mental Hygiene Clinic.
we will be using Libriwn as a comparison drug
some of our study programs assessing the relative
anti—anxiety agents , I believe you would be

Insofar as

initially in

efficacy of
interested in our forthcoming observations and will continue
to cammicate with you.
Thank you very much

for your cooperation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MI':kp

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                    <text>August 28. 1957
Mr.

Stefan

Began

Research Associate

‘

Division of Medicai Affairs
Haffmann«LaRoche, Inc.
Nutiey, New Jersey 07110
Dear Mr. Began:
Thank yau very much for the suppiy 0f Librium, 25 mg,
5, 000 capsules which was received.
We are undertaking a study and
the distribution of this drug.
We

we

will keep records of

are grateful for your cooperation.
Sincereiy yours.
Fink, H.D.
Professor of Psychiatry

Max

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L

E

E

is

E

September 26.

erw‘r—w'”

qﬂywrn

1&amp;6?

Hr. Stefan Began
Senior Research Associate
8epartment of Medical Investigation

Inc.
Jersey 07118

Hoffmann~La Roche

.w

”RF-WW

iWA’c-ﬂfv-

Nutley,

ﬂew

ﬁear Mr. Began:

—'

,,,,

_

r-Ht,‘

«

In order to continue our teaching program would it he
passible fbr you to send as 5,000 capsules of Librium placebos.
25 mg each?
.

«awn-mun

Many

thanks.

—!w-wr‘

Sincerely yours,

1w»

nw—v‘rru,

gamma-u

Max

,

Fink, H.D.

Preféssor of Psychiatry

k?

wwwu

mww—u— .7"

"3v”

11

L

«r

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                    <text>Mamh 21, 19614

Dr. William

P.-

Roger

1m.
Mail Labmtorim.
Camp Hill Road
Fort Washington, Pa.

DearBill:
for ywr letter regarding Dr. Horst Hegel.
561m
her apolOgias, and to these I add my awn.
you
samtazy
have
foam
the armor before I signed the documnt.
shmld
for I

Thank you very mach

My

Please forgiva both of us.

waiting a maponae from Er. Flagal, am look foward to
having him join us later on this year.
I

am

I imam on you to
few weeks, the staff of

May

W

another matter? Daring. tha past
wider
the Irmtitate have discussed the pos-

an ECDEU similar te those established
Clinical Oamittaa. It is my intention to set

sibility of establishing
the

NIH

in the Institute and match ﬁnesse by beans at
the St. wuis State mspital, for studies of wounds which may
be suitabla in the populatiom ordinarily fomd in a state
is a qmstion.
hmpital. Weather such a writ muld be halpful,
one
diacusaed

aside a
Aumg

few beds

tha

0W Mperidcl.associates

pmducad by McNeil,

whim

my

is

have

canapproved by the
andis it
Whom
Is it
stanza?
what
is
its
present
available?
If not,
ﬁnancially

Has

this

still

~

"

now

FDA,

an investigatiohal

comma?

Ineither' case‘, does McNeil Iabomtwies have any interest at
the present in amﬂing its studies of this coupomd, either
pwsibly in tha specialized EEGin a clinical program, orwhich
Gnome Ulatt, Tunan Itil and I
behavioral comlatimm
am so intmstad?
Thank you

my.

mach

for your cmpemtion.

'

Sincerely ymm ,

»

MF/jb

Max

Fink,

Dimctor

24.1).

�</text>
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                    <text>Hammer 1, 196$

Dr. William P. Eager

Hdieil laboratories

Cm Hill

Road

Fort Hashingtm, Ponnsylvmia

190 3!:

Dear Bill:

Eighteen months ago you aroused mm
and aubscqumtly we mdertook a study of

ill. ibis is

interest in trifluperidol
this momd in our seven

limit wand which we studied as an
The effects were not as drmtic as had
been deswibod mad we believe this is largﬂy due to the kind of
population whidx'we brought in for this program It raised some
doubts which we voice in the enclosed muscript and while we am

mentally

early clinical drug

the

wit.

to continue such studics, it seem to me that we are as
likely to miss patent woman a to identify them unless we
develop sure special tricks in the analysis.

encouraged

Dr. Flagel did not com

to join

us because he had another

opportmityinﬁermymdmmlyhaswritten thathamayhave
some time late this spring. Wommly we have filled all the
psychiatrists positions and we am act able to offer
this mount.
I

am

him

a job at

taking the liberty of enclosing a copy of our mmcript
who stinulatcd our interest in this

since you am one of those
command.

Einmmly yours ,
Fink, 94.1).
Professor of Psychiatry

Max

Hfzkp

�</text>
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                    <text>c

n

“a"."1‘“ 35": var-u “v vw-«ww‘ma

-~r-~:m—vw~~m-:axw—rnwn—

«m-n-

mvvvw w-'"I'\vv'n m". .mn—W—VVV- when m w

Khmer 8,

. V_

I

_

w...

-._..,.

1965

v

.
.«
w

v'
‘

—.v-V

W1.”—

wwv

munszmvnV

uramnwmnvn

v&lt;-—v»v&lt;

WMeals,Am

Dr. William P. Bog», Vice
8

Dome

Medical

Affdn

Mid-m:

Inc.

125 Want 31d

NW York, ﬂew York 10023

Dear

Bill:

W
“mm. mmmmmtmnmanme
Thank you

interest“ in

for your letter.

your

mm

Both Dr. 11111 mad

dropaxﬁdol.

I won

Ra

most

has been

carrying out studies with ptmoyclidina (Scmyl) and yew

Wtﬁutmridolwmusodinsmioalm interns“

this? If so.
duswiptim

we would be

11m

Hmy

am.

plowed to nonim copies of any

which any be

tunable.

Sine-My

Mix

yum.

Fink, H.D.

mem of Paychimy

”ﬂap

.,

,. "w" vww

,

�</text>
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                    <text>July 6,

Dr. thneth-Bogga,

1964

Jr.

University of Houston

Bouuton. 201:.

has: at.

Ragga:

In a recent issue of the American Psychologist, your report
on “Theoretical Considerations und.Hathemat1cal Mbdels of
EEG Analysis" is cited as having been praaented
at the South~
was: Psychological Association MEeC1ng in April of 1963. If
that report has been published. I would be grateful for a
aitntion. It_not. in a copy available for our toadingv
Think you very nucﬁ.

Sincerely yours,
Fink,
Diractor

Max

Mlljb

M.D.

�</text>
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Dr. Samuel Bogoch
36 The Fenway

Boston, Massachusetts 022l5
Dear Dr. Bogoch:
.

Thank you very much for sending me a copy of the preliminary
announcement of the next international conference of the Sakel
Institute. You are to be congratulated on assembling such a

fine

list
I

of scientists.

would be

if

you would send such

additional

available for this meeting. as
like to attend with some of my associates.

information

would

grateful

as may become

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

I

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2

1965

'

WW
Meir»
Win

Dr. Z. Bohdmadcy

Deparbmt of

Albert Einstein 001193: of

m1: master and
Bram.

New

Dear Dr.

York 1:31:61

Park

Am
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.

‘

HwYorkattmdingﬂwEmmdmm.mings.

to attend either of those 8381318? If so,
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14.1).

New of Psychiatry

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                    <text>member 2,

z.
k.
naparmmt of

1955

’h

‘

Humming

Albert Einstein Conny of Hodicim
East Gunter md main Park Avenue
Bronx, Nu York 10%1

Burnt. dedamdcy:

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ttonYorkbutstayodﬂmforonlyadaymemuned
E? ”Stain-nil.

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mdlwuldlikeﬂuoppomitytomnyoummofuy

3? tripsmdpoﬁupumm,attmttim,tomotwithyou.
Sincerely yours .
ﬂax Pink,

ma.

Professor of Paydniatr-y

�Mr

16, 1955

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ammmconmowmm

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�</text>
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                    <text>January 3, 1963

Dr. Zdenek Bohdanecky

c/o Research Institute for
Pharmacy and Biochemistry

Kourimska l7
Pﬁaha 3 ” Vinohrady'

Czechoslovakia

Dear Dr. Bohdanecky:
which you
.

Remember

any

I am enclosing the reprints
requested in your letter of

1, 1962.

present, we do not have
available cepies of J. Hillside Hospital
1956

5:67,

At

and 6:197, 1957.

Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

Max

Fink,

Director

M.D.

MP:bk

Encl.

Please address

all

correspondence to:

5400

Arsenal Street, St. Louis 39,

Mo.

�</text>
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                    <text>December
Mr.

W.

H.

l3,

1967

Bold

Clinical Research Associates
Squibb Institute for Medical Research

Manager,

Brunswick,

New

New

Jersey 08903

Dear Hr. Bold:

It

pleasure having you and Mr. Gaglione visit with
as on Friday. As you requested, a copy of the summary statement prepared by my staff is enclosed.

that

The
we

was a

project is going well,

are planning to have a

to the full

at

12:15pm.

staff of the

present supplies
cooperation.
Our

and I

am

pleased to

tell

Department on Friday, February 2,
seem

adequate. Thank you br your
Sincerely yours,

Fink, M.B.
Professor of Psychiatry

Hex

HF:kp

you

presentation of this material

�</text>
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                    <text>WW

1,

”an,“

.mwwm.

w...”

wwqg-

m-I‘FV‘V.2}.

rs

nun-M—

”rm

.1

, .7

i

i

i

February 8, 1958
Mr. William 801d
E. R. Squibb and Sons
Georges Road
New

Brunswick.

New

Jersey 08903

Dear Mr. Bold:
w

‘4
v

i

”0"";

Enclosed is a revision of our protocoi of studies of
fiuphenaZine. These modifications are effective as of this
week and re5u1t from our recent review.

nah”,

I

.
n

would appreciate your making

this

a

matter of record.

\

Sincereiy yours,

”mks..-

.
"vi-v1."-

Max

—~
s.
A

wort.“

.m-Vyrww_

‘

A

.

w-m'vm—W—_~,n

wmmn'

Fink,

M.D.

Professor of Psychiatry

m—m‘rﬂ-mu’ﬂ

Mszp

�</text>
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                    <text>January 8, 1968
Mr. w. H. Bold

Manager, Clinical Research Associates
Squibb Institute for Medical Research
New Brunswick, New Jersey 08903
Dear Mr. Bold:
an

The Prolixin study is going well. He do, however. need
additional supply. of oral Proloxin. l mg. would you

kindly send us

4

bottles.

500

Thank you very much and

tablets each?

my

best wishes for the

New

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Year.

�</text>
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"mu—"mmmv-uv-\w_mwmﬁmwwwrww\W-Ws-

Juno 3, 1964

"to

A1

301‘“:

Kansas City tines
1729 Grand
Kansas City, Missouri
Door A1:

I wish to take this opportunity to personally thank you for e
excellont report on the programs at the Hissouri Institute
of Psyohistry. During the past few years I hsvo drosded interviews fro: reportors, becsuse on each occasion their reports

most

have been filled with trivisl errors which obscured the reel
issues sad the picture which they were trying to present. I
believe you have cspturod the essence of Dr. Ulett's progren.

presenting it will and lost securstely, and
this opportunity to work with you.

had

was

pleased to have

Sincerely yours,
Me: Pink, M. D.

Director

Mlljb

mmwr

�</text>
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                    <text>June 3,

Kt.

A1

1961s

Boling

Kansas City Times
1729 Grand
Kansas City, Kiuouri
.

Door A1 :

I with to take this opportunity to personally thank

you

for

o

at the Missouri Institute
roport
of Psychiatry. During the past fow years I have dreaded intor~
View: from ruportoro. because on ouch occasion their reports
hove been filled with trivial errors which obscured the real
issues and tho picture which they were trying to present. I
believe you have captutod the essence of Dr. Ulott'o program,
ptnoonting it wall and most accurately. and was pleased to have
had this opportunity to work with you.
most oxenllont

on the programs

Sincerely yours ,
Ho: Fink, H.

Director

mljb

1).

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                    <text>77......

.

,._v-w.-,~.

.

a

.,

.

-.-.rr 'W-v&lt;
-

.. v

.—

»

-Vrl'-v—v—vv.‘I—v'~-—y--w--...» «.7...

W" c mu”... yawn-m.- ,,,_,._,,_
.

7.7—.

V

W... _ e. .u

__

”urea..." _.,n««......_...r-

.7

w.

“Ha.

.vv-..

September 5, 1979
Tom G.

Bolwig, M.D.

University Hospital
Copenhagen, Denmark

Dear Tom,

St. Moritz,

Your

where

letter

I had

was waiting
some pleasant

for me when I returned from
meetings, with among others,

Dr. Rafaelson. I will be pleased to have you visit anytime between
October 25 and 31, as I shall be at the University during that period.
The University is about an hour from my home, and about 1.6 hours tram
midtown New York. If you will let me know what other arrangements you
want to make during your stay in the city, I can suggest arrangements
that would be most convenient for your stay.
The study of the the MECTA and other currents is needed.
One such study is underway by Dr. Richard Weiner (V.A. Hospital,
Durham, North Carolina 27705) and a few others have been talked about,
but I do not know that they are actually in progress. Dr. Weiner has
you may
some data already, and
your visit to the U.S. allows

want

to

meet with him.

it,

if

few weeks ago, I received a careful letter from Dr.
that I had mix-read the European usage of ECT in
delirium. He clarified the issue for me, much as you have done. I think
any report in the U.S. Journals which indicates that delirium may be
A

Heshe, indicating

ECT is needed. I regret that the Amer. J. Psychiat.
editors rejected the article. If you would like to have it published
in the U.S., perhaps you should try Dr. Fritz Freyhan (2015 R.Street, N.W.,
Washington, D.C. 20009) who is editor of Comprehensive Psychiatry. If
you decide to submit it to him, indicate that the usage is different in
the two countries, that my book needs amplification, and that I suggested
referral to him. Good luck

an indication for

1

Would you be willing to discuss your work with some of
our residents during your visit 1

Give my regards

pleasant dinner.

My

regards.

to Dr. Rafeelson and thank

him

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

for a

most

7.. e 7,,

v... w _

new—3...".

�</text>
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                    <text>June 13, 1983
Tom G. Bolwig, M.D.

Rigshospitalet

9 Blegsdamvej
DK-ZlOO Copenhagen (0

Denmark

Dear Tom,

It was a pleasure to meet you in New York; and I thank
for your kind
comments about my convulsive therapy history. I have sent a draftyou
the
to
American
Journal of Psychiatry for their consideration.
It is difficult to know what to make about
your announcement about the
electrotherapy group headed by Gary Aden. They are well meaning and well funded,
and they could encourage a better image for ECT, but their
commitment to legal
defense and maintaining present practices made me uncomfortable.
There is still a
need for a reasoned voice in defense of ECT when confused
a
community
reacts
with anger; hopefully, the American Psychiatric Association will
establish
a
committee for such a purpose.
I am unable to come to Vienna for
the World Congress meetings, as I have
family matters which need my attention. Let me know what happens
in the ECT

and EEG sessions.

My best regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>,

rmW.~—-m.

“W‘Fw—nswmh—u

..

-

m——-W

“mmmmm“
,

-

,
.m—u-wwmw—p—«vm—v—w

w

...‘mm.mv—u-—.y

w»-

.

..

_

mm, mm.

... “fume. V7,-.. ._...

December 30, 1985
Thomas Bolwig, M.D.

Psychochemistry institute
Rigshospitalet

9, Biegdamsvej
DK-ZlOO Copenhagen
Denmark
Dear Tom,

At the recent ACNP meetings in Maui, Martha and I had a most pleasant
time with Ole. He seemed to be enjoying himself (when he wasn't politicing for the
CINP or the WPA or the August meeting in Copenhagen).
-

As he had in Philadelphia, Robert Friedel presented a report on the greater
efficacy of the combination of ECT with thiothixene than thiothixene alone in

'therapy-resistant' schizophrenic cases. He reported on nine cases, eight of whom
recovered with the combination, and one who was much improved.

In the discuSsion, Seymour Kety asked what possible mechanism could
Friedel suggest for the greater efficacy; and he presented the view that ECT (and
ECS) produces greater permeability of the blood brain barrier, thereby allowing
greater levels of thiothixene in the brain tissues, for greater efficacy.

had discussed this theory with Sam Gershon, who quickly suggested that
this theory was eminently testable in animal studies. i put together a package of
citations from your summary in the Handbook of Biological Psychiatry, my book,
and that of Stanley Rapaport (Blood-Brain Barrier in Physiology and Medicine), as
well as a citation list for him. He may be able to undertake such a study.
1

Perhaps you have already done such a study? If yes, have I missed it? Are
the data available? If not, perhaps you or one of your associates would be able to
undertake a systematic study? If Bob Friedel's idea gets any play at all, there will
be a rash of trials of the same suggestion, and it would be nice for CONVULSIVE
THERAPY to have a definitive article on this possible mechanism.
Have you organized or will you organize an ECT session for the August

WPA meetings in Copenhagen?

My best wishes for a happy and healthy 1986!

Sincerely yours,
Max Fink, M.D.

.

�</text>
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                    <text>Octdbor 12. 1966

‘

Dr. Roland Donate

The Georg. Withington

university

Bianotric Laboratory

noon 618

-

1145 Hinetocnth

Stroot. n;w.

wadhington. D.c. 20036
Dear Ron.

I have chucked with Don Shapiro and I
think he will be available on Tuonday aﬁtcrnoon,
October 25. in Whahington. Dr. Itil will he at
the unetingn and if we can set aside a major.
portion of‘tho afternoon we dhould be able to
make the necessary decisions regarding the
high data ~ low dose Chlozpronazino - schizophrenia
study.

I look forward to toning

sessionl.

My

you at the 30030
best regards.
sincerely yours.
ﬂax Fink. M.D.

Professor of Psychiatry

ﬂrzkp

cc: Dr. Donald

M.

Shapirb

�</text>
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                    <text>5—wa- -m— «mv

()

~

"1"num'n

aye-n

May

7. 1971

Dr. Roland Bonsto
George Washington University
1145

Biometric Laboratories
Nineteenth St., N.W., Room 618

Washington, D.C. 20037
Dear Ron,

to enclose a copy of our publication
Interactive Psychiatric Diagnosis Programs".

I an pleased

Aided

"Computer

This represents another approach to the problem of diagnosis,
interactive scope display as a way of communicating
with the couputer. I think it has more precise than the SAID
system presented by Miller 25 31;, at the APA.
and uses the

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kt
one.

cw

�</text>
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\j'g'

7M“‘¥léﬁ~m-g;-

March 1. 1966

W

Dr. Roland R. Renato,
The more: Washington Univemity

Bianatr'ic Iabomtow

—~-

Street, NM.
Hiram
20086
D.C.
Hashim.
11%

Dear Roland,

Itgivesmmntplmumtomndywamft wpyof

mmpmmandasmyofmexpeﬂmaindigital
The mama). margins our
for EEG

mlyais.
computernnﬂuods
and I an sun that withinﬁ—D amvumr, ym would
be abletocmyoutmdxaf th‘woﬂbgsmmnwdoing.

prom,

The shorter
Symposium and

report

was pmsented

manta

at the VIIth

IBM

"radical

Menace.
Aeywhm. mwﬂlmlotamdatamlysiaofm
tapes {mﬂymmerinmidmmdwm thenpmoaedwith
scan of the dcﬂnitive diacrixdmmt Wm studies to
datum the We by drugs in ﬁn thmu populatim smiths.
a.

review of our

mummammtmmmswm
find
signﬁfiamt differences
successful for

between

no

we can

mmWinmyoftMﬂwammchﬁmmmm

aspects of
mmnmming. Ifthemmmmbomtive
the
per-ham
whim
interest
you,
this of this study program
tho
analyses
undertake
final
we
6180135
before
them
is
the to
hm.
I

;?’-:”av:9'.~m"wez'

My

best regards.

Stanly yams,
Hex

Pink. PhD.

Professor- of Psydaiatry
9CD

�</text>
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                    <text>Jane 19. 1968
Dr. Roland R. nonato and
Dr. William Guy
George Washington university
Room

1145

Bionstrio Laboratory

618

Nineteenth Street. H.w.

washington. 0.6. 20036
Dssr Ron and Bill.

I want to thank you for the data outputs and
tho
for
tins you spent with no on Friday. I discussed

tha outputs with my associates and we are pleased with
the nothods of presentation. I pointed out that we
were missing the drug-dose data and these forms ars
bsing completed now.
Enclosed ars two cepies of the laboratory report

which describes the standards

in plscsbo traatod patients

during my stay in Missouri. I think this is an important
nodal for all drug studies.

I look forward to seeing you

Monday.

Sincerely yours,
Max

Fink. M.D.

Professor of Psyohiatry

nfzkp

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                    <text>October El, l968

0r. Roland Bonato
The George washington University
Biometric Laboratory

ll45 Nineteenth St.. h.H.

Washington. D.C. 20036
Gear Ron.

It was a pleasure to discuss our interests in the
laboratory data scale. and if the least that was accomplished
was a definition of the need for our laboratory reporting
system. that will have been much.

1px

:',1

12-747mm

'

Enclosed are the figures and a data output from one of
our experiments. The prints reflect the changes in a single
measure over time, with the ordinate being either percent
time (for the individual frequencies). cps (average frequencies)
and relative amplitude. The dev measures are standard deviations.
The abscissa is a number of samples which must be multiplied
by l/3 for number of minutes.

reprint of one of our reports as well as the preprint
of the fenfluramine paper may be helpful in understanding the
The

report.

My

best regards.
Sincerely yours.
Max

Fink. H.D.

Professor of Psychiatry

.

.

.,

Fave-50mm“,

�</text>
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                    <text>February

216,

1964

Dr. Ron Bmato

The George Washington University
Biomtric Laboratory, Roan 618'
1145 Nineteenth Street, N. W.

Washington 6, D. C.
Dear Run:

Oantml

I finislmd editing the enclmed abstract fw tha
Society (a meeting which I did not attend became

As
BBQ

remindadofwr
Ihavebcenillsime leavingFlm‘ida) lam
EEG
had
dlscusaim about the

of
War analysis
mm.

and

that I

We are enclosed
prwdud to send you sons of our
and mpmsem: serially, an early pmqentatim to the 1620
mr's

mp, for the
this abstract

an addemhnu

presented yesterday.

EEG

for the

MN? meeting

in Jamary, and

Society which should have been

Ihawtakenthelibertyofaandingoopiesofﬂwse

damnts to Dr. Ham for his infomatim
I

would be most

as wall.

plamd tohave you Visit us.

We

are

nwinﬁmmicbtafﬁwsmdydeswlbodinﬁmabstmctandm
middle
ehculd have sufficiont data to
ofMamh.

make some

judgmnt by the

The earth fm your laboratory concerning my Hillside
experiences arrived safely. Many

rm.

My

best regards.
Sinmmly yours,
ﬂax Pink, H. D.

MF/ja

enc.

nimctor

�</text>
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                    <text>March 2, 196‘

Dr. Ron Banana
The Gnorge wankington

Biomatric Laboratory,
1145 Ninﬂtoench

Washington 6,

Univatsity
Room

Strelt,

Do Co

E.

618

W.

Dtar Ron:
Rosemary has

told

my

visit to Florida.

whole family of your nauing her during

Sh. is to delighted. that but stator
has asked when she. too. will hava a chance to use: you and

the

find but "trua"

name.

Rosemary has asked

to

visit 3:. Louis.

that I

quad you but

love,

and

invite

you

If you at. as much a hit with :hc girls in Washington as you
are with my daughtots, your wife nut: have coneidarsbla cans:
for nutty!
,

Sinatraly yours,
Fink.
m
Dirncaor

mm:

MID I

�</text>
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                  <elementText elementTextId="103416">
                    <text>»

«

47.1w.

ﬁrmu’rr‘u',

&lt;——,~

brawn—“W

.

ﬁu-r-z

M's--

.-_‘..&lt;r,-—

February 19, 1971
Mr.

J.

Bondoux

Manager, Systems DeveloPment

Biochemical Procedures
12020 Chandiey Blvd.
North Holywood, California 91607
Dear Mr. Bondoux:

their

you

Both cyclazocine and naloxone are experimental drugs. For
chemistry, availability outside our laboratories, I suggest

write the manufacturer:
Endo
1000

Laboratories
Stewart Ave.

Garden

City,

(naloxone)

New York

Sterling-WinthroP Research

Institute

Rensselaer,

(cyclazocine)

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>December 23, 1963

Dr. Raymnd Banner
maxim J. Watson Laboratories

I

B H

Yoﬁctam {higmtm

New

York

Dear Dr. Banner:

I was attending a aolloquimn at the university
meessor R. Hum indicated that he had heard a re-

Recently,

and
of
port of yours. cmoeming pattern recognition of the electroencephalogram. This iii a subject of man: intezwt to our laboratories in
St. lads. and I would be grateful for a copy of the mpwt, if that
is available.
_

Miami.

,

My

m.

Sincerely yours ,
MEX

Fink.

Dimctor

Mleg

No Do

�</text>
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                    <text>February 18, 1987
Philip L. Bonnet, M.D.
114 West Franklin Avenue, Suite K-l
Pennington, New Jersey 0853‘;
Dear Dr. Bonnet,

It is not clear from your letter how i can be of assistance in the
understanding of your interesting case. The symptom of fatigue and obsessive
compulsive symptoms, in the absence of physical justification as in recurrent
hypoglycemia or a muscle wasting disorder, may reﬂect persistent depression.
The descriptions of prior courses oi ECT andthe cinguiotomy are too
scanty to determine their adequacy or their effects.
We would be glad to have the patient seen at our center, following receipt
of a more detailed history. Evaluations maybe done as an out-patient or as an inpatient, depending on the patient’s needs. Appointment can be made with my
secretary at 516-14“ 2929.

Or, you may consider consultation with my former co-worker Dr. Donald F.
Klein at the Psychiatric Institute. He has made a study of patients with unusual
syndromes of depression.
-

Thank you for the inquiry.

Sincerely yours,

Max Fink, M.D.
_

Professor of Psychiatry

�</text>
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                    <text>:ercuﬂf‘mﬁllz;

av

«‘Mﬂl'lgﬂﬂn‘ﬁ‘w

wwwﬁw—wvzmmmrwr

15¢?“er

“vi/3r

Irvww

7458-09083
4 March 197é
Edward

J. Callahan,

Ph.D.

Research Specialist and

Assistant Clinical Professor
of Psychiatry

U.C.L.A. School of Msdicins

Csmstillo~ﬁouropsychiatrio Instituts
Rosssrch ?rogrsm

Box 'A'

Camorillo, California 93010
Dear Dr. Callahan:
Thank you for your invitation to participate in your
research program. I have read your project proposal and it is
indosd interesting. I would be delighted to serve as s con~

sultant.

I so enclosing a recent

summary by Wiklsr which may augment

your formulation, as wall as a copy of

my

vita. as

you requested.

Sincerely yours,
kink, M.D.
Professor of Psychiatry

Max

Wlois
Encls.

�</text>
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                    <text>7

V

,.

”,7 v.

W

.

,

my ,...

. a..-“

7, -\‘-.wV‘V—‘w

‘n-I'J‘" -q~w-.-u an'r “w,

w“.- m"...

7383-738~33

15 Octobar 1973

M E K

0

R A

H D U H

To:

Stanley

Prom

Max

I.

Fink.

Yollca,
11.».-

M.D.

w

Subjact: Tanhiatoacopa, Cit. and lvant Ctntrol Syatan

.

The

taahiatoacope and CF! arc davicas that proaant visual stimuli undar
rigorous control of input variablaa. This paruita tho capatinantat to
naaaura accurataly the Itata of vigilanca of a auhjact and tha lavcl of
brain function parfomca. Chang» in than manna at. diract indicaof organic noutal states and tho affacta‘of drug: and paychiatrit traatmanta. Thay are alao being appliad as a nan-are of the ahanxaa producad
by tha aehiapphtanic ptocaaa. For exparinaatal atudiaa by uadieal ata—
danta and follows. than: davicaa ara invaluabla both as roaaarch and an
taaching toola.
(a.

The Evan:

Control System permit: ch. roaaatchar to present stimuli

through the tachiatoacopa or CF?) with tigeroua central of dura~
tion ..and aaquanca factota. thus permitting careful aaaaaanant of changes
in vigilance, brain function. and tha long~tarn cifacta of paychoain.
This ayatam is also applicabla to tha projaetad studios of conditioning
in our capandad narcotic addiction resaarch program.
HF/cia

�</text>
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                    <text>August 5. 1968
Dr. Phi1iip H. Bookman
Department of Medicai Research
Hoffmann-La Roche, Inc.
Nut1ey. New Jersey 07110
Dear Dr. Bookman:
I regret that a satisfactory parentera1 form of R0 5-3350
does not exist, since we are embarking on a project in which
we wi11 have standards applicab1e to the anaiysis of this compound.

indicated during my visit, I am particu1er1y interested
in evaiuating new compounds in order to determine the popu1ation
of choice for c1inica1 efficacy. Perhaps when you or your
associates find another compound that is in the very eariy c1inica1
screening we may have an opportunity to review it with you.
As I

Sincere1y yours.

Fink. M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>August 22, 1963
Dr. E. A. Whinstein
7107 Hymn Road

Bethesda 1n, Maryland

DearEd:

Ithaaboenjwteyursimalhevemtoﬂiswuri,andsim
tim.tmmbemmnydmmsintm labomtozyhem. We
nowheve fmmwardswith 66 patientsgmandmimlwmmm
laboratories ends.
of

this

Wmtionel.

anddespitemwheadmhee,alotoffum

Ithae bane lot

work.

You my well imagine the eavinisuutive demands in equipping
and staffing 9. enter;
projects and obtainim
have been met. After considerable
I mm’ced the

time
pm
Wt,
problemth
Wwofﬂnﬁvismnmdmthofmmd
thatowmtmlintematmuldbebeat
time reward: position.

served

ifIaasmdafull

'me laborataries hem are miquely equip-

pedtowwoutmymmintemsts inbrein Marionmdbehavior.

making an application to the Nat-10ml Institutes
Ware.
ofmnmihalthforemeppoinmmtdemtmdngmuberty

I

am.

of emitting your name as one of my mfemmes. I should be grateful
for your mmmndetiom when; the emitte- lamina. (I am also
taking the liberty of enclosing a copy of my Wham Vitae which
my be of help to your
My

best

We

mm).

Sincerely yours,
Max

MPzew

«we.

Pirk,

muster

21. D.

�</text>
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                    <text>6,

w

June 25. 1975
Mrs. Jan Boppe
2957 Kalakana Avenue
Honolulu, Hawaii 96815
Dear Mrs. Boppe,

It was kind of you to write after seeing the film on
depression, to tell me of the tribulations in your family. Unfortunately,
the story that you tell is all too common, and all the sadder since,
as you note, more could be done for many of the mentally ill of
America, were the press, the professions, and particularly the
law willing to exercise restraint and good Judgement. The press is
guilty for expanding on the mysteries of our treatments, and for
equating all biological treatments as shock treatments. The very
language is forbidding. The professions (medical and psychological)
are at fault for not insisting that all treatments that are
useful are equally to be available and to be used, insisting that
some are not 'cleaner' than others. And the law, for daring (as
they usually do) to interfere in the relationships of patient and
physiscian.
The

results are often the tragediy that

all too eloquently.

you recorded

My associates and I continue to study the convulsive
therapy process. I believe we have learned much and are now planning
yet another series of studies to improve the treatment process; and
another conference which may be useful to educate our peers.

Again,

my

thanks for writing and sharing your experience.

As a separate thought, should you be interested, there
devastating article about ECT published in the New Yorker
in the summer of lQTh. The article was written by B. Rouche. He
tells the stody of one patient who received ECT inappropriately
and complains persistingly about memory loss. His biased article has
been qudted by many patients who wished not to have ECT. Should you
get the article, you may wish to write to him and express your story.

was a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Executive Director

Max

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                    <text>“m

mvr—w-.- Vﬂru— W.ﬂ‘mmm—w~wai'»i'wcvn—'wwu—:.—...w_..a-,. ...,.

w

,

__.

,

.

vi

_

.

.7

_.

_

. n

V

_

_

‘_

w,

‘_,,___V_, ,__,

i
December 29, 1975
Mr. Gavin Borden,

President

Garland Publishing, Inc.

ShS
New

Madison Avenue
York 10022

Dear Mr. Borden,

your

letter

I recall the flight from Houston with pleasure, and
stimulated me to retrace the conversation.

It is

simple for me to send the enclosed report, which
was put together by one of my students in June, 1969. We have since
used it as a text for resident physicians at our training center, and
.

1'7W"-&lt;1‘.

Wm'm'wmﬂ'mm-wwﬁw

on various occasions, I have distributed copies to students at other
schools, usually when I have been asked to lecture on the convulsive
is clear that some sections
therapies. In reading the volume today,
should be updated, the references augmented, but on the whole the
descriptions remain quite accurate and useful.

it

difficult, however, is to estimate the market.
experiences with the publication of a conference proceedings,
I am of the opinion that advertising is more important to the sale of
a volume than the content. An estimate of the utility of the volume
and its sales would depend more on the advertising than on the details
or their accuracy (although I could assure the reader that the text
is as accurate as possible).

Following

More

my

Should it seem feasible, the text could be updated and
revised within a few months. Perhaps you would read this text, and
if there is some interest, we could meet on one of my next trips to the

city.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_

_,

,

,_

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                    <text>April 2.

9

1964

Dr. P. Betunstetn

ﬁapitai Paychiatriqun d: Villtjuif (Seine)

ruin ,
Hon

France

char

Ill:

Canal van: 1:

sass: pcut tutu la conitt

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25

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An

prisant je projctta d'ctra

touts fugue,

19

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var:
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an pan plus

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Aunt.

La bibliographic an: 1'(1actro¢ncaphalogtanna cc paychapharmncologta
humaxn gar: publi‘ cat Cut. Jo continua d: colloctur lac rufaranccs

rocnvoir Ion
article: out as aujct a: 3'appructrat btcn dcminus
at
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Pink, 3.
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�</text>
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                    <text>..
«r

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'

73SB~81883
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19 December 1973
‘3
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11mm

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Julian J. Leaky,

Ph.D.

Executive Secretary
Clinical Projects Research Review Committee
Division of Extramural Research Programs
National Institute of Mental Health
lOCZS--Parklewn Building
5600 Fishers Lane
Rockville, Maryland 20852

Room

Re:

'5'"

MB

25608-01

A

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»-

7"

gq.
w,

Dear Jack:

I have read the proposal,

"EEG

and

Changes during PsyDr. Reilly proposes

VER

Reilly.
psychiatric patients (N - 24).
In addition to a psychiatric evaluation using rating scales for
mental status, he proposes a systematic EEG recording for back—
ground EEG by visual interpretation, and for the visual evoked
response. Recordings will be done prior to drug treatment and
at weekly intervals for the duration of hospitalization, for at
least six weeks. He also proposes monthly recordings thereafter
between the second and sixth months. The date are to be snalysed by complex statistical procedures of a multivariate type
by consultants who are experienced in statistical analyses but

chiatric Treatment" by Dr. E. L.
to examine a small population of

not

EEG.

The mission set by Dr. Reilly is a most commendable one.
the problem and
My comments can be divided into four sections:
and
conclusions.
methods, facilities, significance,

1.

Problem and Methods

The problem selected by Dr. Reilly is a significant one.
In the description of the EEG recording and visual analyses,
he describes acceptable methods reflecting his experience as
an electroencephalographer. However, to describe a project in
1973 using visual description methods of a decade earlier may
reflect a lack of experience with newer methods of EEG quan—
tification. If the choice is based on data, then he should

~'»£Jﬂ'M"w":/“I

-1-

�.-

.....A.

J. J. Leaky,
explain

problem.

I

-2-

Ph.D.

why he uses

19 December 1973

non-quantitative methods for a quantitative

concerned with the diagnostic criteria for psychiatric
It is unclear whether Dr. Reilly has the experience
to select patients carefully, as the problem requires. (This
question should be answered in a site visit.)
am

evaluation.

I am also concerned with the one-to-two-day drug-free period
prior to the initial EEG. Considering the wide use of drugs,
varied dosages, etc.. this is inadequate. I do not have a good
solution, but I would recommend placing all patients in a defined
group on the same medication for a specific period of time before
the

EEG.

issue of diagnosis—related EEG measreported that the die differences were
a more parsiménious explanation of the differences found between
schizophrenics and depressives. Dr. Reilly does not indicate
an awareness of this major pitfall in such research.
ures

When we

some

examined the

years ago,

we

Thus the issue of quantification, psychiatric diagnosis,‘
medication and age controls, in addition th the small sample,
make me question the likelihood that the goal will be reached.
The application is also unclear as to whether VER, or resting
are the foci of the study. The application lacks a specific
hypothesis reflecting potential effects in either measure.
EEG,

2.

'Facilities

The physical facilities seem adequate to the task, although
I anticipate that Dr. Reilly will find that recordings made on
a Becknsn recorder will not be satisfactory for computer pro,

ceasing.

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.r,

:y-rvlcn—‘vr

«mnp-

.r.

”,1

”WW,

wwwme

1“,.

rm—

Dr. Reilly's training seems adequate for EEG and his coworkers are physiologists and statisticians. The participation
of a psychiatrist (a behavioral typologist) seems lacking in

the study.

'

The funds requested seem unusually modest. Considering
the talents ascribed to the consultants, the sun requested
($3,000) and the computer tine ($600) are inadequate for the
analyses described in the text. While modesty may be a factor,
I believe lack of experience is a better explanation.

�J. J. Leaky. Ph.D.
3.

19 December 1973

~3~

-

Significance

of physiological indices for the classification
of the mentally ill and for the description of changes in psychiatric treatment are very important issues. The problem has
The problem

been approached by many investigators.

The

literature survey

presented by Dr. Reilly is adequate, although there are significant omissions, particularly the studies of Shagass, Callaway, and Monroe. Again, the references to clinical electroancephalographers, especially those associated with Knott, Wilson, and Doty, are well reported, but the contributions to this
problem by psychopathologists are lacking.
4.

Conclusions

cannot help feeling that Dr. Reilly is an enthusiastic
in climbing a small hill in the lower
Appalachian Mountains, who became excited with the possibility
of scaling Annapurna. The goal is commendable, but he seems
to have learned only the rudiments necessary for this task, and
1

young man, experienced

I

do not

believe that the prognosis for success is favorable.

But how can one encourage such an

sible to

recommend

that he spend

it poswith Callaway,

interest? Is

some time

Shagese, J. Small or Itil to obtain additional psychiatric
experience relevant to the problem which interests him?

I would also suggest, if one can, that he become acquainted
with Neil Burch and Peter Kellaway, both in Houston. These men
understand EEG measurement and can probably contribute to his
data processing. He should become acquainted with either Bernard
Salteberg of Tulane or Stanley Feldstein of the University of
Maryland. Both of these men have devoted many years' effort to
the statistical analysis of complex EEG data, Seltrberg with
Burch and Feldstein with me. (I would ask that he be advised
of the work of Dr. Burdh, for on Page 21 he says, "There is no
other source of the programs in running form available in Houston."
It is my understanding that Dr. Burch has had quantitative EEG
programs for background 339 and probably AER in running form
since 1966.)
'

I trust these

comments

are helpful.

I believe a

be encouraged to climb mountains when he has had

man should

sufficient

ex—

perience to handle these problems-~for climbing the mountain that
he has targetted is a worthwhile experience.

�“0 “a, -m.
w-

‘

._.v,,.‘

A

,.

&lt;

.

V.

J. J. Lalky, Hub.

-4-

19 Dgcambat 1973

u,v

..

.

Thank you

Sinceruly,

.v-:rw.&lt;wmn—vu_.-—.A..Y....

Fink, MOD.
Prafansor of Psychiatry

M‘x
-.wr7l=r

a,”

H

for the opportunity to rcviaw this application.

Hrfcis

M

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                    <text>July 10,

.

vrw—r-

mvn‘Wr-1"\Rn"mmm

mku—m—

mm

197”

Carl Sandman. Ph.D.

Veterans Administration Hospital
1601 Perdido

New

Street

Orleans. Louisiana 701h6

Deer Carl:

enclosing a copy of my letter to Abbe in the be—
lief that you will be able to supply me with the additional information that I need for filing of-theee two studies.

I

am

I am also taking the liberty of enclosing a c.v. of a
assistant, Steven Knhn, who has worked with me for one year.
He has been accepted to graduate studies in psychology at Ohio Stone
rand was one of the candidates that you interyiewed some months ego.
Should you be looking for a young and capable research assistant.
young

I

would recommend him
My

to you.

best regards.
Sincerely yours.
Fink, M. D.
Professor of Psychiatry
Mn:

Merd
Enclosures

.

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                    <text>Septeubcr 10, 1964
Deccan: Pinchan Boranatein

Hﬁdectn dc: Boptttnx PsychtAtriquas de 1- Salas
71. Quai Branly

Sag.

69—60
Paris V11

Irnncc
Mbu

Char Boston: Borenstein,

Bursa: non court 1‘10“: 1 Paris. 30 van: at téléphoné plusieurl
£910; nuts 11 m'écait innonsthlé dc vans atteindre! J'ésperaia
tons vet: 1 Birmingham oh; J'Gaais (salamant dccn par votre
absoneo. Lynn: 1a votro non dann 1: programnn. jo-m'attondain
1 watt! ptrticip‘tion In rinnian de 013?. Je rngrotte de vous
dirt qu'tl as n"tnit pas possible do présenter votre non gn
CIR? an moi: dc Mai ear. Dr. Preyhennm'uvait signnlé qua la
Qanité s'itatt d6]! riuni pour fairs den nominations. Je 32:11:
hnurunx d'&amp;cr1r maintcnant den lettrea qui sont nécassaires at
assure: 13 support dc Dr. 310th pour votra candidadura et calla
dc Dr. Cahn. Voudriuzdvoua nvoit In bonté de m'envoyer 1e
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reunion 6:31:

b1¢n~®1do sans Vans. De plus. pas une Beale
parsounilitdo ital: presents. Un congr‘a d'unc
calla twortmm (can: msqu'un ichac at quelqnu unod'ie nos
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an nail pas exactmant 5‘11 aura possible on non d'artangor la
typn t‘union qua vou: cvna propooi ~ 3 mains qua voua attendiez
due: innécs.. Le Beaten: Delay visa: d'ltre 1e président; at
l'oceasion an présonee, pout~atre arrangera~t~11 an meilleur
caustic.
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a r‘ccnmnnt publié on Turquie. 13 livre du Docteur Itil at 10
van: 1. recoumnndc comma Gtant d'ua grand intérét pour voua dang
votrn travail.
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                    <text>September 4, 1970
Dr. Finches Borenstein
Hopital Psychiatrique de

71, Quai Branly
Paris VII, France

Villijuif

(Seine)

Dear Pinchas,

I missed you in Prague, hoping to see you again. The
meetings were quite interesting, although too large with too
many simultaneous sessions.

Recently, I became interested in sulpiride when a friend
mentioned your studies suggesting that this compound may not
As you know, I am most interested
fit the EEG classification.
EEG
studies in new drugs, and I am writing to ask
in continuing
you would favor me with some data. Hey I have any recent
if
summaries of your work with sulpiride? In what cases do you now
—

find

it

useful,

and

at

what dosages?

are the profiles of sulpiride in patients?
volunteer data been reported?
What
Do

you think another

I will be graterl
wife and associates.

EEG

study

may be us ‘ul?

for your advice.

My

best regards to your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

Has any

�</text>
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                    <text>April 21,
A

1969

Dr. Allen P. Berger, M.D.

Pfizer Pharmaceuticals
Groton, Connecticut
Dear Dr. Berger,

on

CP—

Itil.

I have rovicwod tho letters and the clinical data shoots
larger folder to my consultant. Br. Toron
Tho FD
1A,368; and cent the
1572

is onclooed.

Before completing a proposed protocol. I would like to have
the benefit of Dr. Itil'a comments. It will also be notes-ary to £11:
a protocol with our College authorities.

I note in your letter a desire to undertake this study before
the end of April. I regret that such a timo~tablo is not foaaiblo since
I would like to carry out thoue studios myself, and I am committed to
a oonforoooo and none pita vioito in Europa from May &amp;«20. we will be
able to run our initial trials during the first week in June and carry
out some of the exporimonts until late July when I anticipate a oumnor

hiatus.

I trust this

timo schedule

is acooptoblo.

ﬁany thanks for the Opportunity to review the notes and to
propose a study of CP~14,368.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>W

Dr. Allen P.
Associate Director

(has. Pfizer

8

00., Inc.

Groton, Camecticut 0630.0
Dear Allen,
Enclosed is a proposed analysis of CF 115368. Instead
of the usual two-step, I am proposing a three-step study in
which the first few subjects will be studied in an Open
eituatim in order to determine dose - time relationships.
A defined Open study will give us the approﬂnate classificatim
and

this will follow Dr.

Itil's

reconnendatims.

If we

are

successful with both these steps , we will have the necessary
infometim to do a definitive classificatim study.
Dr.

Itil was most helpful.

If this program meets with your approval I would appreciate
a supply of 50 capsules (tablets) of 50 mg C? 114,368 and an equal

umber of placebo.

The study can be begun as soon as supplies

are

made

Sincerely yours ,

1m PM,

2". DO

Professor of Psychiatry

MFﬁcp

,

n;iw,v.,mw.y..,

«w

~/('

.w

.

“r.

.
.

June 3, 1969

available.

�</text>
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                    <text>May

28, 1969

Dr. Allen P. Berger
Associate Director

Pfizer

Chase

&amp;

00., Inc.

Groton, Connecticut 06340
Dear Allen,

It is

kind of you to

make

lithium available for our

clinical trials, and an FD 1573 is enclosed for filing.
I have asked Dr. Jovan Simeon to assume responsibility for
this project, and have submitted his curriculum vitae for
filing. If you wish additional curriculum vitae's,including
my own, we will send them as well.
arrange
If the protocol is agreeable, would you please
be
should
This
tablets?
of
1.000
send
supply
an
initial
to
sufficient to get the group started.
Our

other protocol is being sent separately.
Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>..-.

r
”w.

..

.v—qurww,

August 23, 1969
Dr. Allen Berger
Chas. Pfizat &amp; Co.

-

Groton. Connecticut

Ref: 0? 14»368

Dear Allen,
We

have completed an

initial act

in volunteers, in single eral dosages of
was in a single trial.

50

to

of

trials

of

350 mg. Thu

CP—14,368

latter

dose

To daca, nu have failed to obscrvn behavioral or EEG effects
during tha initial 2 hour obnctvation period; and the subjects reported
no behavioral consequences for the ensuing 12 to-ZO hours.

continue theta trials, we wish to ameﬁd the protocol
earlier, to allow trials (single, oral) to 500 as.
T6

submitted

Pleaae verify.
Sincerely yours,

Max

Fink, M.D.

Professor of Paychiatry
mf/

�</text>
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                    <text>August

ll.

l969

Dr. Allen P. Berger

Associate Director
Department of Clinical Research
Chas. Pfizer a 80.. Inc.
Groton, Connecticut 06340
Dear Allen.

Enclosed are two copies of the study "Assay of Oral
and Capsule Drug Dosages by Quantitative EEG

ﬁancentrase
r ter a.
we

have begun the data

run through Saturday of

this

collection this
week.

morning and

will

Since the meeting of the FDA is not until next Thursday,
I believe you will have more material with second trials as
of Monday afternoon. Our schedule calls for twelve subjects
to be tested Monday-Thursday with their second testing on

Friday. Saturday, Monday and Tuesday and their third testing
during the remainder of that week.
Also enclosed is a letter regarding the review of the
thiothixene oral concentrate HDA.
My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF2kp

enc .

�</text>
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                    <text>August

ll.

l969

Dr. Allen P. Burger

Associate Director
Department of Clinical Research
Chas. Pfizer a 60.. Inc.
Groton. Connecticut 06340
Dear Dr. Burger:

for thiothixene oral concentrate
considerable interest. I have reviewed the
clinical data and find that the data is consistent with the
following conclusions:
The

NBA

was read with

summary volume

l. Thiothixene concentrate is an active psychoactive
the patients exhibiting decreased psychotic symptoms.
parkinsonism and sedation. These features were reported in all
studies in which daily doses above 20 mg/day were used. The
agent

«-

symptoms were equivocal

at lower levels.

2. The two studies which compared the clinical
efficacy of capsules thiothixene and oral concentrate reported
similar clinical effects at comparable dosages.

a

-

3. Tables of the reported secondary effects of both
patterns of

forms (capsules and oral concentrate) show the same
effects with a similar incidence.

Furthermore. the dosages. clinical and secondary effects of
the reports of oral concentrate are similar to our own studies of
thiothixene in capsules reported in l967. and I would have no
hesitancy in undertaking clinical trials of the concentrate
in treating schizophrenia at dosages comparable to thiothixene
capsu es.

-

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

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                    <text>October 7, 1969
Dr. Allen P. Berger
Chas. Pfizer Co., Inc.
Groton, Connecticut 06340
Dear Allen,
CP

May I

please have

14368-1, 50

mg

each.

an

additional bottle of

100

are undertaking additional studies at the higher dosage
present supply will soon be exhausted.

We

and

my

Sincerely yours,
Fink, :‘IQDO
Professor of Psychiatry

Max

MF:kp

capsules

�</text>
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                    <text>September 2, 1969
Dr. Allen P. Berger

Chas.

Pfizer

&amp;

Company

Groton, Connecticut
Dear Allen:

RE:

Thiothixene

—

Study

EEG

I have reviewed the studies of thiothixene oral
concentrate and capsules, undertaken between August 1
and August 23. Using the protocol dated 8/21/69, we

have completed 27 experiments.

variability in these experiments has
in part, occasioned by our failure to carry outhigh,
a
more complete preliminary study.
Enclosed is a revised protocol (III) dated 8/25/69,
The

which summarizes our initial experiences and
which is now operational.
This study

is running well

within six weeks.

isthe

and should be completed
.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

one

�</text>
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                    <text>November

7,

1969

Dr. Allen P. Berger
Chas. Pfizer 6 Co.
Groton, Connecticut 05340
Dear Allen,
As

I discussed, we are undertaking a study of various

in childhood disorders. For the reasons described
in the protocol, which is enclosed, we desire to provide
medication in liquid vehicle wherever possible. Our preliminary
compounds

.

study of Nevane (thiothixene) in concentrate form assures
of its activity.

me

necessity of filing an IND or any other
FDA
like to request supplies of thiothixene
concentrate 5 mg/ml sufficient to begin this study. May I
ask for 50 of the 30 m1 bottles with eye dropper and
15 placebo to start?
Thank you for your cooperation. My best regards.
Even with the
forms, I would

__.

Sincerely yours,

-,

.
.
A.

.1.

.N.

.2...“

-m.v-

w

.:.

n:‘-Iwrnr

:r-n-au—

fur-.7

”w-

"‘W““Wl“§'f

ﬂex Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>November

7.

1969

Dr. Allen P. Berger
Chas. Pfizer 5 Co.
Groton, Connecticut 06340
Dear Allen.

the

year trial of doxepin (Sinequan) in the clinical units.
representative
If agreeable to you, would you either ask yourMrs.
Cruzado,
the
pharmacist,
available
to
to make supplies
500
would
I
capsules
suggest
them
office.
my
to
or deliver
50
and
25
mg to start.
each of

a

W'wtﬂwmm

At the suggestion of my associates, I have requested
Formulary Committee of Metropolitan Hospital to allow

1

comparison
report of our doxepin - cllordiaaepoxide
EEG
data is
The
doxepin
and
in
final typing.
is
is complete
be
Both
available
will
draft.
and
in
is
its initial
complete
for distribution to our staff by the year's end.
The

’m‘v

tr
Yam

:

Sincerely yours,

72am”

.7."

an?"

-,
v.

iu'r'

Fink, ELLE).
Professor of Psychiatry

Max

qup-

L‘Astz'lrurv-nnvu

MF:kp
'WWIKMW»

1?
"7

1
‘

’

‘3’?”‘9‘1"!

9'“
.5?

�</text>
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                    <text>January 20, 1970

&lt;
.
v,
a

”at

’&gt;"IV.u—&gt;r"'

.vr

:u-.-

q.

,-

.Avﬂesnmnmm

rt"

71

an
an
w‘...

1..-

V-zr

shim

-.-=.~.

Dr. Allen P. Borgor
Chas. Pfizer &amp; Co., Inc.
Groton , Connecticut
Dear Allen.

is a revised protocol of the EEC « thlothixene
concentrate and capsule study. You may recall that in the
first definitive study we misjudged the time of onset as
Enclosed

well as the dosage.

Based on this experience, we have retlsod tho study
which now is in progress and is approximately one~quartor

completed.

Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

HF

:kp

�</text>
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                    <text>January 19, 1970
Dr. Allen P. Berger

Associate Director
Chas.

Pfizer

&amp;

80., Inc.

Groton, Connecticut 06540
Dear Allen,
I will be pleased to participate in the meeting at
Kings Park State Hospital on February 4. In the event
that it will be difficult for mo, I will ask one of my

associates
My

who knows our work

thanks for the

to attend.

invitation.
Sincerely yours,

a!” Fink,

MJJ.

Professor of Psychiatry

Mﬁzkp

-'y
r.
V

_

'

5RX"“'

«aw-r

‘1'2~"'.r.~"1‘

"v

..

W”

�</text>
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                    <text>r.—m-m-m-~1n.

January 19,

1970

Dr. Allen P. Berger
Chas. Pfizer E Co.
Groton , Conno ct i cut
Dear Allen,

Enclosed are three copies of the final report of our
study of doxepin and chlordiazepoxide in anxious outpatients.
This report has been sent to Cuttcnt Thehapeut£c Rebeanch
for their consideration.

Separately, I will send a more complete final report,
and copies of the various rating scales used in the study.
Earlier, you obtained a copy of the statistical analyses

of the Biometric Laboratory.
Again,

study.

my

thanks for your cooperation during

this extended

Sincerely yours,
Wax

Fink,

M.D.

Professor of Psychiatry

Hﬁzkp

enc.

�</text>
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                    <text>F'"‘“"w‘""W-Wv—— v—v—m w‘

-

-

hr-VM'H—

WV“ wrwv.~—~—- ..,..,‘r..,~‘—-W.‘Wm

7.4

w.—vy-—mv-v.—.W._w ”mam—w... ..‘..w-~...‘

.77..

y

.w.“

m.

,

.

-

«mun-w

ww'

January 16,

1970

Dr. Allen D. Burger
Chas. Pfizer % Co.
Groton , Connocti cut
Dear Allen,

is

interim report dated January 4, 1970
of the first ohaso of the EEG profile analysis of C? 14.368.
The report summarizes our observations and concludes with a
reCOmmendation that we use 250 mg as the single dose for
the phase two studios.
ﬁnclosed

an

list

of oxperiuonts
sheets
for the
and subjects, I am enclosing the actual data
be
These
useful to any other
behavioral observations.
may
investigators who may be interested in the effocts of CP 14,568
in normal volunteers. I am also enclosing summary work sheets,
insofar as these may be of interest.
In addition to the summaries and the

Two

additional copies of the

distribution.

summary

are enclosed for

The phase two study has begun and should be completed

within four months.
Thank you

for your cooperation.
Sincerely yourg,

.

1

Mszp
0116-.

ﬂax Fink, H.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="103207">
                    <text>January 4, 1970
Dr. Allen P. Eorgar, M.B.
Associate Director
Pfizer Pharamceuticals
Grotoa Connecticut
Dear Allen,

Enclosed are tha

1573 for the study of thiothixene/
anxiaus suhjacts in the partial hospitalitation
program at our College. This atudy has met the ayproval of the
ralavnnt local cnmmittees and will be prasented to tha Resaarch
Coamittce at it: wanting later tits month. I believe the study
can begin as soon as the supplies art made available.

thioridazina/placebo

FD

1n

we will submit a
rtqutat for support for this study,
based on the anticipated completian cf 30
subjects before tha and
of the year, of $10,000, plus $3,000 for Sallega
overhead. In the
evant the study 13 not comglated, tbs suppctt will be negotiated.
Paymant 13 to be made at the and of the study.

Enclosed also are Farm

FD 1573 Gor the thiothixene
capsule
study in children and adalescants, following the protocol we submitted
soma aontha ago. It in my understanding that as seen
as it is
feasible, you will reconsidar the possibla use of thiothixane
1n
concentrate form in this study.

Many thanks for your coaparation, and
a successful 1970.

my

best wishes for

Sincerely yours,
‘

‘

'

c..d""

Max

.1231»

a
"
5'"

&lt;

w

awn

wrmumxe“

mlmpﬁwm

Fink, M.D.

Professor of Psychiatry

(“an

at]

�</text>
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                    <text>ii

a

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7‘-

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.

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A

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n

,

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m;

-.vaW.—wr

February 16, 1970
Dr. Allen P. Burger
Chas. Pfizer &amp; Co.

Groton , Connecticut

w

,‘1

1

man

Dear Allen,

wart-rm

n'

-

Separately I am sending you the part of the sample of
thiothlxene which we are using in our EEG study. ﬁy staff
reports what appears to be a diminution in clinical affects.
If it is possible to biochemically check it against the
standard, I would be grateful to know that it is as active
as expected.
Hy

best regards.
Sincerely yours,
Fink. ﬁ.3.
Professor of Psychiatry

Max

HF : kp

,7—

�</text>
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                    <text>~— -.v-;——vv--_~u~

Wuwww.wwn——.W.T— m—

mw

- «"I’w‘vwv‘w... «.m..- .._

.i-

.

.7

,

v7.7".

m”

r—- ___, ‘_.._m-——r——W-—-—rv—-—v—--—vww—w

"w.

a—
—

March

~—

i9, l970

Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Gro‘ron , Connecficu'l'
Dear Alien,
,
w“:

.
~

.‘w

.~

-

.wmwewvwmwfw.»

3.,ww-wwnww

'—

.—

Separately i am sending you The complefed dafa sheets
of +he doxepin—chlordiazepoxide sfudy. You have already
received the Biometric Laborafory analyses of this dafa.
i am enclosing the card ouT-pufs as
supplied by fhe Biometric
Laboralory for fhe use of your sfaficlans.
in addifion

Biodala, inc.

i

am

enclosing a laborafory dafa oufpuf from

Enclosed wifh This ioffor is a more complete final reporf.
This includes some fables no? submiflad To Currenf Therapeufic
Epseargh, Thu? report has been accepted for fheir April issue.

if

mifflwm‘”

has boon a pleasure working wifh you.

Sincorely yours,
.--.

Max

v

"3‘

,...

van.»

V-i.v

‘40.“.

v-

Fink,

M.D.

Professor of Psychiatry

aer‘I-err-ra'w-y—

MF:kp

�</text>
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                    <text>vv.‘.“‘l

-vw—~x'wl|‘i|"'-"1'~ﬁ~Vr

"ww:

March 19, 1970

|p';ﬂva-Tvrn

Br. Allen P. gorger
vagwwra.w--—ku.w

Chas.

Pfizer

ﬁ

Co.

Groton, Connecticut
”-

'x-u

.

Dear Allen,
As you will recall, Hrs. Simeon and Nikolovski
interested in treating the failures of the doxepin~

became

chlordiazepoxidc study (as well as the doxepin successes
after 8 weeks) with a ”stander “ drug. They selected
thiothixene and the enclosed short protocol is the
modification of the doxepin-chlordiazepoxide study that
they used. Also, enclosed is the summary of their
observations.
Separately I am sending you the case summaries, and copies
of the various NIHH study forms - personal data inventory, drug
study resume, brief psychiatric rating scale. clinical global
impression and treatment emergent symptom scales. The Biometric
Laboratory hes analyzed this data and their report with a set
of the data card outputs are enclosed.
The

v—w

-'

«saw-‘2‘"rr'wrnmzw

laboratory data

was analyzed by

their output is also enclosed.
Based on this information,

we

Biodata, Inc. and

have proposed a more

study. s protocol of which has been sent to you.

I onticioate submitting the
JOurnaZ of’th Drugs and I will

answer.

report of this pilot study to the
notify you as soon as I have an

“NI—Www'!‘

Again,

my

thanks for your cooperation.

rT

'rIir-.4i

definitive

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>&gt;anwrwm mwnww~m—»wmwvl_~.

.wv W

T

.V.

..

.,

July 17, 1970
Dr. Allen P. Borger, M.D.

Dept. Clinical Research

Pfizer

&amp;

Co.

Groton, Connecticut 06340
Dear Allen,

of

Doxepin,

7/15/70.

a draft protocol for the EEG Profile Analysis
Comparison of Pamoata and I101 Fomulationo, dated

Enclosed

III:

is

In reading the initial human data, it seems that the
reduces
the rate of absorption, and we are projecting an
pamoate
extension of the duration of each drug experience to 3 hours, rather
than the 2 hours we found sufficient for oral doxepin (3C1).

the time you read this, I will have tried to reach
meet on Wednesday afternoon, if possible; or
you to ask that
another afternoon later in the week.
By

we

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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July 16, 1970
Dr. Allen P. Berger
Chas.

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,
A

Enclosed is a corrected version of the cidoxcpin study.
small addition was made on page four.

I find that Dr. chtanaga will be able to start the study
in August 1‘ the supplies are available now. we have asked for
10 mg capsulca, and matching placebo. tau you make 1000 of
each cvailable?
Sincerely yours,
.
at
'v
"or.

"r“,

Fink, 14.1).
Professor of Psychiatry

Max

r-wrr

""1

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one a

MM;

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July 9,

u.

,7,

,r,

3

E

E

é

1970

Dr. Allen Berger, M.D.
Associate Director
Pfizer Pharmaceuticals
Groton, Bonnecticut

:

g

Dear Allen,

%

g

the

FD

Following your message, I recalled the envelope with

forms enclosed, and added the following?

E

E

%

68—06~26:

68-06-25:

g

i
i

68—06—27:

for the lactate study, including,
form
Anxiety scale for infusion
Forms

Initial evaluation

Taylor Anxiety symptom check

list

Article from Archives gen. Psychiatry, by Curry et 31.,
Factors Affbcting CkZorpromazine Plasma Levels in Psychiatric Patients,
vol. 22:209—216.
I trust these are useful.
Sincerely yours,

.A

"w"

Max

‘va‘nI-Kﬂqup‘—VV7

mf/
ru-u'ﬂ’

-:
'

r-vwwawrxv-v

w'

vxvn-

u-

‘wﬁwmn"w"ﬁw'mwxw~

Fink,

M.D.

‘

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v

n

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-,

-- ~-.-,—,.\._

q . Jam-w urn-cavin—

�</text>
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                    <text>July 3,

1970

Dr. Allen Berger

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,

first

I enjoyed your visit
installment of the material

on June 23, and I

we

am

discussed.

enclosing the

have prepared a protocol for the assay of the
Infiuence of.PCPZ"5h Tolerance and Physical Dependence in Opiate Addicts.
We have reviewed the administration schedule, and following your discussion,
have added trials of PCPA on alternate days and daily, if the schedule
of every 4 days is inadequate.

1.

PCPA.

We

,

for this project, that
is one technical problem5-HIAA.
we do not have
and
5-HT
urinary
blood
of the measurement of
have
contract these
and
to
will
the facilities for this measurement,
can be done in
unless
they
commercial
laboratory,
measurements with a
assuming the
contract
the
costs,
Our
for
estimate
your laboratories.
is $3,000.
number
tested,
of
maximum
cases
project proceeds to the
There

have reviewed the data on cidoxepin and
Presumed Anti-Anxiety,
prepared a protocol, Elinioal Trial of CidaxapinWe
would
like to assess
Dependence.
Anti—Depressant Agent~ In Opiate
2. Cidoxepin.

We

in this
the possibilities of clinical trials of anti~depressants
of patients.
number
limited
a
in
and
a
suggest trial
special population,
and
clinical
dosage
define
range
a
able
be
to
In this study, we should
definitive
a
be
able
to
suggest
will
activity, and based on this data,

trial.

We

the

summer

holidays,

the supplies

be able to begin the cidoxepin
on or about September 15.

will

trials

only

after

(we can begin the PCPA study in mid-July or as soon as
are made available. 200 capsules of 25 mg. each should

be adequate to

3.

start; with
EEG

matching placebos

if possible.)

Trials in Prison Volunteers. This suggestion is

most interestingT"EEa‘yaﬁf'f5116ﬁ=ﬁp’feliphoﬁ3'call to indicate that
your technician will visit us on July 17 confirmed our enthusiasm. To
will be necessary that equipment be available
carry out this program ,

it

..,.,

,
a
A-

.
-‘Wrwv

�at the prison to insure recordings that will be useful. I will
describe our procedures and caution the technician, but the following
should be considered:

equivalent to Grass polygraph with 7P511 amplifiers.
Grass Instrument makes a small 4 channel instrument, which can be
initially equipped for recording on 2 chainels only. $4,500 ($3,000)
EEG,

Tape—recorder for FM.

to the Hewlett Packard

A

3690A.

small 1/4 inch unit equivalent
$4,285

Oscillator, equivalent to the

2020

HP

$

425

Oscilloscope, for monitoring, preferably dual

beam, any make equivalent to the Tektronix 561

inexpensive.

The

tapes, paper,

$1,000

and other supplies are

relatively

it

would be useful for me and one member of my staff to visit the installation and develop the initial
protocols in collaboration with your staff there. I would envisage
the recording of EEG samples on paper and magnetic tape; having the
paper records examined in conjunction with the clinical data; and then
analyzing those tapes that seem the most useful for the definition
of drug dosages using the advanced computer techniques of the EEG

Prior to the studies,

laboratory.

not have a 1/4 inch FM tape
unit in out computer center. It will be necessary for us to provide
a duplicate unit or for you 00 lend us your unit whenever we undertake
the analyses of the tapes.
As

I mentioned,

we do

4. EEG Profile Study of Doxepin Pamoate. I have not
received the pharmacological data for this formulation, and so have
hesitated to prepare a protocol, but will do so as soon as the infor—
mation is received.
The thiothixene-EEG

reports are progressing rapidly.
Thank you

these diverse studies.

profile,

and the

for your suggestions,

CP

14,368

EEG

and I look forward to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

profile

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'
£77!-

K.

January 20, l97l
Dr. Allen P. Borger
Chas. Pflzer &amp; Co.
Grofon, Connecflcu?
Dear Allen,

are conflnulng our Navane - Thlorldazlne sfudy and requesl
an addlflonal supply of:
We

IOOO

capsules Navane

2 mg

Label enclosed.

Slncerely yours,

Max

Flnk,

M.D.

Professor of Psychlafry
MF:kT

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                    <text>F

,wv-

‘liw‘m ~—v—*m‘&lt;wxw ‘m .

o.

own-'17

‘

‘

,m

‘

.‘

mar?

‘59,,

mun

’r-vnruwx'

,.

r.

.
A

_‘_V

.,

"www.mw"

~v—w.-w,._u..m

m,m.,,_V..."_."—Ww

-w.-..~.~2,.

January 15. 1971

‘rﬂwm-r~w-\qr

Dr. Allen P. Berger
Chas. Pfizer &amp; Co.
Groton, Connecticut

E

Dear Allen,

Enclosed are copies of the anxiety rating scales for

ouch of the

subjects in the

Simoon thiothixcne open‘study.

I trust those are helpful.
wanna-unau-

Sincerely yours,
nrwmm

Fink, M.D.
Professor of Psychiatry

or

Max

"mun-war

I.“-lvwx-ukw

MF:kt

cnc .

V

-,w-—

,

".mWWM,

r-,--

«aw-u... )l'lrfhm’m_

�</text>
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                    <text>February 25. 1971
Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen.
EEG

Enclosed is a supplementary statement regarding the
effects of thiothixene 1n depressive outpatients.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>2
w—v-»&lt;-,.
rum—aw

1

V;:'.r\ 4:- , v 1w.

-;W..,

_

v

any
e

x

,

_..

,.

,._'21‘r.-m

w rm.»
wmrxam-m
-

-

-a

~;/.«.m.«,~:-r-.&lt;.rzan.ar-w.;:wmv:wv-w;--.«~mnr

v

v-1

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Arr» m- wvyv "

:~ ‘V'n‘a'l-

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1..

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lewJI-w

"as,“

February 9, 1971

A

~..

~

.Iznaryw—vm-v-

mum-,2

Dr. Allen P. Berger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen,

"nw'mm,

I’vnu-Fyew'VK'

~

WrT-msawmnn-mwnq

Enclosed are four additional "incomplete" records of
patients in the thiothixene~th10ridazine—placebostudy.
Please make whatever copies you wish and return as you
did in the earlier data.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

-r

.

..

H

vw-“v

.:

m» -.4

~

-x

,

_.

...

w“, wan."-

�</text>
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                    <text>—-

...,

it

am.

.-

W.W.mmwym.«u

."mw

;
.
'1,V¢r&lt;

.W‘N‘"

--awrrxuvr-u-

m-

,l.
E
E
g.

a“ «vuv—z-”w -v-

»

wam-

v umn

uni-tum“

:

."1'Jr

2-:

:.,:~.~,-|.~w.‘-. .-.1 ”0......

awn/«'3‘ ...,_-,Vu

.. ,v, n... a...»

May

~r .

“w”... ... q...

., ...,.,..

TFFTT“.

.77.”.

7..

-.

,

..._..

J”... .,

15, 1971

Dr. Allen Berger

Associate.Director

Pfizer Pharmaceuticals
Groton, Connecticut
Deer Allen,

Separately, I am sending you two boxes containing
duplicate copies of the report of our studies of doxepin hydrochloride
and doxepin pamoate using the EEG profile methods for determining
bioavailability and dose equivalence. These may be fileé and
submitted as vou wish. You will note that some of the actual EEG
analyses may be obscured by the reproduction and binding process,
but the originals are on file in my laboratory and will be made
available as requested.
I am also sending you additional copies of the summary
and the data summaries. This is the material that will be

report
useful to you.

most

I

am

very pleased with the results, for the technique
clear answers with a minimum of population sampling.

seems to provide
Many

thanks for your

interest

and encouragement.

Sincerely yours,
Max

Fink, rm).

�</text>
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                    <text>..

«WU—Ir:

Av

n7,

.

vww-r

-

v.»

-

your

‘m‘w':—’Wm“mwmwvw—u-

w—

ur-

-a

nu— mum—he

mum-w—»-' «mw—m—vrrv , ma»..—

rm

...

no”.

mnw-w-mu-T

um,

Wng-"rﬁos'r

~

dnwr

ran—.222»,

ww'wv-—w

'mav'"

v15?

May

“‘wa

warp.“

4wrvn'w

‘

FWW'V'K-Vrn’rtrwmw'

~

7, 1971

Dr. Allen P. Berger
Chas. Pfizer 5 Co.

Groton , Connecticut
Dear Allen,

letter of May 25, 1970, I indicated that Drs. Simeon,
and
I
Spero
are agreeable to having the reprints of our report,
”A Comparison of Doxepin and Chlordiazepoxide in the Therapy of
Anxiety" distributed to physicians by your professional representa~
On my

tives in the course of their visits to physicians; or in the
course of their replies to inquiries. We indicated that the article
not be used in the usual promotional material or quoted out of
context as a general endorsement of this product.
Dr. Oliver Nikolovski concurs

in this approval.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

n, wanna-mm“..—

�</text>
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                    <text>November 16, 1971

Dr. Allen Berger

Pfizer Pharmaceuticals

Groton, Connecticut 06340

Dear Allen:

Enclosed are two copies of the behavorial data summary
of the comparison of doxepin hydrochloride (25 and 10 mg) and
doxepin pemoata (10 mg) in male volunteers. The behevoriel

data parallel: the EEG data quite well. It is this date that
clarified for us, the differences in behavorial data obtained
on a moment-to—moment basis compared to summary data at the
end of an experiment.
An

quested

My

extra

it.

capy

is enclosed for Dr. Beckett, as she re»

best regards.
Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Hex
Wu".

MF:ig

Inc.

�</text>
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                    <text>February 28, 1972

Dr. Allan P. Berger:
Associate Director

Pfiur Inc.

Eastern Point Road
Grown, Connecticut 06340
RE:

Lithane

ERR 2/13/72

Dear Alan:

are most grateful for the supplica of Lithane (lithium
carbonate) which you so kindly made available to us in 1970. Silica
that time we have trested more than 20 patients, neatly those unifaring from mania, and the supplies are exhausted.
Re

Early in 1971, Lithane was approved by the fomulary courmlttee of ﬁetmpolitm Knapital Medical Center for psychiatric uses,
and is no longer "investigationnl" and not under out control.
Thank you

for your assistance.

ﬂy

best regards.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry
has:

�</text>
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                <text>1972 </text>
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              <elementText elementTextId="51762">
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                  <elementText elementTextId="101346">
                    <text>Match 7, 1966

Dr. William Borgcr

Mcﬁall Lgboratorleu,
Camp

Hill

Road

Inc.

Pbrt Washington, Pa;

Dear Dr. Bazaar:

I

writing at the auggaatlon of Dr. ﬂorat Flagal. who has
indlcntcd a dualre to join tha staff of tha luttitnta :- u
research "'G¢1't¢t
am

I would be grateful for your commantn regarding Dr. Flagel's
ability to cannunlctte with psychiatrie patients in English,
an outinatc of hi: ability to undertakc independent rataarch,
and ht: ability ta got along with his co~vorkhra.

‘
A
_

nwmgp

_,

as has indicated that he would like to learn more abaut the
«valuation of behavior‘l thange, espoclally our-mathodl cf
rating patiouts. As you know, the Missouri Institute at
Psychiatry 15 a clinical rcaaarch cautar established by
Dr. Ulctt. .I am taking the liberty of enclosing a copy of
our first annual report, as this will give you a picture of
our proton: programs.

I

grateful for your candid comments_aa to whether
Dr. Flegal would be able to participate in a mutually eo—
0parat1vu way.
would be

Sincaraly yours.
Fink.
Director

Max

um»
Eat.

W»,

‘

I‘LD.

�</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text/>
              </elementText>
            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9332">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          </element>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="9333">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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                <text>en-US</text>
              </elementText>
            </elementTextContainer>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="81696">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="88257">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="94818">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
