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                    <text>3M”

April 23, 1979
Albert J. Stunkard, M.D.
Professor of Psychiatry
Hospital of the University
of Pennsylvania
205 Pieraol Bldg./Gl

‘

Philadelphia, Pa. lQth
Dear Mikey,
much

I will miss you
less erudite.

on

the

V. A.

committee, and the sessions

will be

I found reading your report on fenfluramine interesting and
The data tables are more imgresaive than the figures, which
suggest that the placebo treated subjects lost almost as much weight

useful.

.

;

f

as those who were medicated. The graphs indicate a median loan of
9.5 kg for the medicated aubJecta and 7.5 kg for placebo. What was
the secret ingredient in both groups? WOuld the report be strength—
ened by adding some weight lose data? Have you considered OPT for

these data?

report of our study on fenfluramine is enclosed. we were
less interested in the clinical effects than in the EEG profile.
In another study in 1968, we carried out an open trial of fenfluramine in obese subjects, found sedation and dry mouth with weight
and appetite loss. We did not publish these data, which were
useful principally in examining whether sedation or stimulation
occurred in our subjects, as a follow-up of our EEG assessment.
A

My

regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:bc

Encl.

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                    <text>‘

March 4, 1970
Mr. Herb

Sturz

Institute

Vera

30 East 39th

New

York,

New

Street
York

Dear Mr. Sturz:

Enclosed is a draft proposal dated November 27, 1969, which
describes our suggestion to the National Institutes of Mental Health
and to the New York State Narcotic Addiction Control Commission for
the development of a long acting narcotic antagonist.
Since formulating the proposal we have had additional experience
with cyclazocine which makes us believe that the same principles and
techniques should be applied to the development of a long acting
form for cyclazocine as well.
For either naloxone or cyclazocine, the first step is the
development of a slow release form and a determination of a maximum
amount

that

can be concentrated in a

silastic vehicle.

The

initial

animal trials must be undertaken to determine the release rate.
These pharmacological aSSays can be done by a number of American
consulting firms. If this formulation is successful, then concurrent
animal and human trials must be undertaken in the animals for toxicity
purposes and in humans fer toxicity and the determination of the
duration of antagonism.

requested are for the pharmacological feasibility
such actions appear logical to you and your committee,
associates and I would be pleased to cooperate in any way possible.

only.
my

The fUnds

If

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
enc.

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                    <text>wx. ,..‘,. ('"rpum

May

Mr.

4, 1970

Harberf Sfurz

Vera lnsTifufe
30 Eas? 39+h Sfreef
New York, New York
Dear Mr. $+urz:

‘n reading The lafasT WHO reporf of 1+5 ”Expert Commiffea
on Drug Dependance”, concerning ifs l7fh mee?lng, Augusf 25~30,
1969, ! nofed commenfs which ara ralevan? To our lnfaresf. I
am Taking fhe liberfy of sendtng you fhe anglosed pages (24-26)
of who Technical Rﬁporf #437, Geneva, 5970.

Sincerely yours,
"an Fink,

#900.

Profassor of Psychiafry

Mmkp

enc.

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                    <text>vmvwwc-

JUlY 9, 19Th

J. Khatin,

Abba

M.

D.

Veterans Administration Hospital
1601 Perdido Street

VP"

New

Orleans, Louisiana 701h6

7v"?!

Dear Abba:
urﬁmv‘r'wff‘

w;
'1'
w-u,

"(VW‘I

mew-r"

filing of the

I have received and will have

no difficulty with the
two protocols evaluating ACTH/NEH h~10 in schizo~

phrenice and retardetee.

toeol:

.

-'-,-v-

WWI-PW

a)

Copy

b)

A

I will need the following for each pro-

of the consent form.

small description (2 to h paragraphs)
of facilities at each hospital.

c) The

official

Columbus

Institute

name of the committees at
State Hospital and Coluﬁbue State

which

our protocol.
d)

will (or have) approved

Since Dr. Sandman is not on 24.13., it would
be most helpful if an M.D. at the Institu~
tion is cooperating in each protect. If
such be aveileble, we should have a short C.V.

I have Just called your office and find that you are
already on holiday and so I will probably see you in Utrecht before you receive this letter. I shall be able to file the necessary
supplement as soon a: the above information is available.
My

beet regards.
Sincerely yours,
Me: Pink,

MF:ed

cc:

M. D.

Professor of Peychietry

C. Sandman
H.

van Rieeen

nt—

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                    <text>June 2, 1976
James F. Buses, M.D.

Department of Psychiatry and
The

Human

Behavior

University of Mississippi Medical Center

2500 North

State Street

Jackson, Miss.

39216

Dear Dr. Buses,

I am pleased to write this letter of recommendation on
behalf of Oliver Nikolcvshi, M.D.
I have

staff at the

New

He was assigned
He participated

known him since 1967 (or 1968) when he Joined my
York medical College as a staff research psychiatrist.

to the out—patient department-where he has served since.
in clinical studies, particularly evaluations of new

psychhactive substances in thettreatment of the mentally ill. His work
is‘a methodical, reliable, and careful worker.
He is liked by his patients and crestte a cheerful atmosphere with
his

has been exemplary, as he
co~vorkers.

I relinquished the role as chilf of the clinic, he
realised as a therapist. and from time to time, participated in ongoing
experimental studies. He has always been willing to assist in studies
'and my co~vorkers have called upon him after I left the College in 1972.
When

has been unhappy at the College since he has not received
advancement that he wished. I would recommend him
[or any clinical position similar to those which he has held, and
believe him qualified in clinical psychiatry and psychopathology.
Unfbrtunately, I have not had the opportunity to assess his teaching
ability as this is under the supervision of others at the College,
such as Benjamin Sadock, M.D. and Alfred Freedman, M.D.
He

the professional

I trust these remarks are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>February 10, 1965

Arthur Sugarman, M.D.
Chief, Investigative Ptychlatry Section
A.

New

Jersay Heuro~Paych13tr1c Inatttnua

Box 1000

Princeton,

New

Jersey

Dear Arthur:

is a letter tram my secretary regarding your exponccs
to vial: St. Louis. Sinca this is being paid from the Resident
Training funds, yuur statement ingluaeo a $50 honorarium.
Enclosed

With tagard to noun old bﬁiintlt, I cook the ranpounihility of
submitting your regort on EEG ana.Bahavarlal Ghangcs to Dunn
Clyde and his staff. Dr. Crane: was kind enough to critique
tha statistics, and I am enclosing a not. for your uso. I: 13
my inpxnaston that thuy would be racpoutive to additional £n~

quitlan frou

you

if

you wish.

I am embarrataed regarding Turan’s dissertation. Apparently
the cupy which I gave you 13 the o££1c1:1 unlvcrulty diaacrta~
clan. For purposes of clarity and in ordar to add additional
data which the university felt abauld not be includeé. and which
cgmo after his thesis had bocn accapcea. ho but asked his publltha:
to issue a second odltion including chm additional data and an
English summary. To avoid umbarraasmenc. I have not told him
that I gave you a copy - as you know, ha-would ha upuet. I wanld
be grateful if you wauld eaturn the copy after you hays rand 1e,
and I will use to it that you as: the more canploto adiulon It
soon as

it

is availablc.

'

‘

.

to the growth of this staff, I am pleased to have you
considcr joining us. There are two pacltions open ac_the luatltute
at the present tint for which-99a quslify.

With regard

I an interested in catabllshlns another clinical ruccntch unit,

eudovud

25 or 59 beds in the Institute and
bad: in the State Hospital a: as any wiab.

initially with either

supported

by go many

�Dr. A. A. Sugcrman
Zulo-éé
?cgc Two

This unit ahould he devoted to the kind of program. which you
have so ably dcvclopod. including curly clinical drug evaluation.
touting of specific hypothesis of drug action, and for aomc cor-

related laboratory studies.
In

ECDEU,

tion,

some

I

would

spacial

to soc new coopoondo tested in out populalit:
cmphccis pcthcpa on adolcacontc and the agcﬁ.

cantor is a fertile ground for ﬁnch studios, but require:
leadership which I think you can give it. copeciclly if supported
by the ohcctvctiona of tuna patients in our own words. Once such
studies are undertaken. the laboratory studies, especially EEG.
will bccomc a concurrent part.
Tho youth

second position is a senior one, with the additional tccponcibility of the Resident Psychiatric Training Program (requires
pcthapc 1/3 time) and the opportunity for a clinical unit of the
Institute. At the present time the Psychicttic Training 9togtcm
is supervised by Dr. Ulett and myself. Ha otc anxious to have
nomcbody who is principally recoatoh otiontod to expand and develop
this program. It is our goal to have on many of our residents as

A

possible outer research at

community

servico cateots.

In either position, I would consider your appointment as equal to
that of Dr. Gerohoc, Dr. Itil, or myself.
.

this will permit the division of 150 beds into four
it,
the
for
units
present. It may be possible in the next bicnnium
another
senior investigator with clinical responsibility.
to appoint
In that eventuality. we will begin to take responsibility for some
of the facilities of the hospital, using our beds for those observations which must ho made in the units. At the present time, for
example. Sam and Sol have 1A patients in the aeuctnl Hospital - thcy
are a control group for a number in the Institute for ono of their
studico.

As

I see

and Huntington Uhivotaity is
review
the
undotgoiug
at
present time; however, the appointments of
and Gctahon have boon approved by the appropriate faculty
Dru.
committcoc, and I cxpcct than to ho concocted at tho and of this month.
I would be plcacod to rccoanond your appointmcnt and can covilion no
problem in that acorc.

The

rolationchip bctvccn the Institute

ltil

Solution at the Missouri Institotc of Psychiatry are based on o 48
hour wank, cincc they are on a full tinc basic. Senior noicntiots
ate appointcd concurrently to the Institute and to the Psychiatric
Rococtch Foundction of ”inconti. tho latter hot and. pocniblc a
anchor of pccroquioits, including a totircucnt honciit through
TIAA at a rat: or approximately 10! of colary. Tho Micoouti
Instincmc of Psychiatry cclaty range is $18,000 to $21.000-pct
annum for the position. we cto discussing, to which the Revocation'a
101

is

«Good.

It

in our hope that the Foundation's contribution

�Dr. A. A. Sugormuu
2—10—6b

Page Thtoo

will roach 202 within thin biennium. In addition to a boon
salary plus a Foundation commitment which inolodoo rotiteoooz
bouofito, chore uro allowance: from tho Institute for eravol
and nomberohip fees. which make it unnaooloory for no to havo

many

profeooionol orpenooo.

With regard to your quootion about u hiatus - I do not think
that this would occur for you for as long a period on it hos
for no. Ploolo realise tho: whom I can. horo to had on oupty
shell and
is only in the past few months that l have boon
able to undertake some studies of my own.

it

populatibnt here are similar to your own. and tho facilities
are already eotablithod to that you oould work with tho ovoiloblo

The

equipment

until your

own

The growth of research
The present advontagos

wore

establiohod.

inatituteo is

a phenomena in.Amorica.
one has over onothor is largely the
support given by the goront body. Twonty—fivo yoars ago when
KY?! was organized, it was given sufficient iopotus to become the
outstanding reoearch center of that period. sad it ho. called on
that reputation ever since. Other conters Ilka Err}. IPPI, and
those of Hebraoka. Oklnhoma, and Indiana hovo not shown the
growth originally envisioned for them becauso they veto never

givon the

I

that

initial ouoport.
know if this Institute will

do not
ho liko HY?! or EPQI, but
have roceived magnificont support from the State and the
community. The additionol support from the Rational Institutes
of ﬁenlth has been astonishing, and with the addiciOn of a few
meta research psychiatrists. I believe we will have one of the
we

finest clinical psychiatric resoareh centers in tho notion in a

very short while.

additional advantage of location in o largo.cit§,
direct affiliation with a university with excellent groéuate and
undergraduate programs, with national and international reputationn,
the backing on our own grounds of a 2,800 had State Hospital, tad

go have the

a new

It

facility

was a

easily.
to vioit no.

which cannot be matched

great plan-ore for

you

Sincerely,
Fink. 3.9.
Director

Max

33/51:
833 o

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                    <text>ow
my 26, 1965

I‘m. A.

W Sum

(311d, Investigative Psychiatry Section

Haw

Jamey Name-Psychiatric

Box 1000

Primetcn,

New

mﬁmte

Jamey

mm:
Imttotakethisoppmitytotlmﬂcymfor

DmMnrjmiamtomdm-ingﬁmmeemAPAHectings. Imethim

thanextmingatbmakfast,andfmmdhimtobeasophisticated
and mptianlly well qualified inmtimtor. I was most Wed
the compatibility of our interests, for-not only didwa have
similarity in the BE field, but his interest in linguistic dovetailsverymllwithnyam. Ywmykmwtlntwemmwinﬂn
ms
linquiutic
process of testing an of our
by

- mum

arm

glamestedﬂntmispmwnigxtbeofswciﬂcinmmtto
Howwar, as one of the few, well trained young

inmtimtom,

Maillhavcmnyopportmitiesmdlmpectﬁutrnwillmm

dwinimmﬁwbasisofenvizmntalaawellasscimtiﬂc
him, andeant, arm
again, mﬂnnkwaorﬂﬂnkingofus.
cmsidmtims. Wewmﬂdbepleuedtotnve
My

best wishes.
Sincerely yours,
Max

Firm,

Prwcafesscam~

M.

D.

of Psychiatry

�</text>
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                    <text>July 2.

1955

Dr. A. Arthur Sugomm

Chief,

Imstigativo Psychiatry Section

of mum): in Naming 8 Paydmiatry
old New Jenny Newﬁydxiatric Institute
Bureau

Box 1000

Princeton,

New

Jersey

Daar Art:

is self~explmatozy.

mm
I will met

The enclosed

send Dr.

Hay

I suggest that

a cepy of your auriculmmim.

you

pleased if Gordon Merisson would considar
joining us. for since our breakfast in New York, I have received
only mutant mﬁmnts concerning his work record from scan
be

of

mm}. aoquainanaes
'Ihank

in
you once again for

New

York.

ramming him.
Sincerely yours.
Hm:

Fink,

H.123.

meassor of Psychiatry

unclasum

'

�</text>
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                    <text>July

39 , 1965

Dr. A. Arthur Sugemm
Quief, Inwstigativo Psydmiatry Section

of Research in Neurology 6 Psydmiatry
Jersey Mauro—Psychiatric Institute

Bureau

cl 0

New

Box 1000

Primoton,

New

Jersey

DearArt:

to

One

of

in

you

coworkers, Dr. Alexmder Don, who has written
past with mgard to yotmatudies of trifluperidol

my

the.

is planning a visit Eat in Hid»3epter&amp;er.

has asked which

He

laboratories he might visit to observe program boﬂi aimilar md
dissimilar to our own. I recommended that he visit with you,
chiefly because he has had experiences with tﬁfluperidol that
diffor sonawhm: fm your om, and because I think he should
see an operatimal ECDEU Unit .
_»

He

will either write or call

you and

will try to visit

If you am at all available,
I would be grateful if you oould arrange for him to perhaps
see some of your work, Lemied's and Carl's and perhaps own
if Harold Pranks is available, I believe he would be most

during the week of Septenber 21.

interested in his

work as

well.

Imidantally, Dr. Merriam has written to no as you
indicated he would. I regretted vary much the moosoity of
writing to him ﬂat the program have also have mmntly
been filled and for the first time we are faced with the
strictuma of wt being able to fill major positions dining
tho forthcoming year.
I

would be

grateful for my midomtiono

you may give

Sinoemly yours ,
Pink, Md).
Professor of Psychiatry
Max

�</text>
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                    <text>September in , 1965

W.

14.13., Med. D. Sc.
Arthw
mief, Investigative Psychiatry Section
New Jersey Nam-Psychiatric Inetitute

A.

Box 1000

‘

Primemn,

Mew

Jersey

Dear Arthm‘:

I

am

writing with

some

«110:! my to
family. and has mauled his

that Dr. Don me My
newillness
in his immediate

England because of

trip to the East. I am mteful
for ymm willingwea to show him your fncilities. and I rope that
he will have an opportmity m visit with you mtim next spring.

IanhofyerEGpmgmminVimna.
Maren
new demure which are developing freeman-y analytic

umber of

8mm
brain m”. In either
men
We
that
instm. they have given reference to the kind of

methods

W

V

.
y
....-.‘

,...e

7‘

forth: Myofﬁmnmmewithdmgs.
with

awhaeiaing the

mlmmtariasammwmn-yingout.

work

Keepw‘dzegoodmrk:

Sincerely

yam.

air,

“—9,

Fink, Md).
Professor of Psychiatry
Max

rwwmwwwuyna—w.

«7.4

warns-var

rﬁﬁer-a'wuo"

5:,»-

.,
m
p;

(,

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.’-“‘""""'"'*"‘

‘9‘!"

'mmw‘

£07513?”

mﬁvf

�</text>
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                    <text>�Dr. Sugerman

~2-

June 6, 1967

If the suggestions for page six. are acceptable, then I am
pleased to have my name added to the participants in this letter.
If it is felt necessary to include the ad hmulnem statements,
then

I muld request not to

Thank

be included

in the signatoriea.

ya: for the opportunity to participate in this dialogue.
Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

.

A

V

r“W‘HWW

,

�</text>
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                    <text>Dr. A.

m

May

29, 1957

Sugerman

Chief, Investigative Psychiatry Section
Man of Research in Hemlogy 8 Psychiatry

c/o

New

Jersey NemPsychiatr-ic Institute

Box 1000

'

Wton, New Jersey
Dear Art,

Ihadtheopportunitytothinkaboutyowletterin

response to mo’s editorial and would like the opportmity

tojoinyw. Ifynuwillsendmaoopyofmmplyas
soonasi’tismvised, Iwillcallyouassoonasl

haveMdmeopporthitytomadit.

Simemly yams ,
Pink, I‘M).
Professor of Psychiatry

Max

Mfﬂqb

�</text>
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                    <text>”may?

,—

-‘

.........,.

y«"1'w~‘~w.14\~

‘. \wxr (m7. -7».

.

——,v.y.,.

_

”no—pm...-

September 8, l967
Dr. A. Arthur Sugenman

Chief. Investigative Fsychiatry Section
Eureau of Research in Neurology and Psychiatry
c/o ﬁew Jersey Neuro~Psychiatric Institute
Box

000

Princeton,

New

Jersey 08540

Dear Arthur,

Enclosed is the application and

corrections

a

set of suggested

which have been added to the xerox copy. Please
note the corrections in the eqiipment and supply costs.

Please call

me

if

there are any questions.

Good luck!

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFtkp

'
V

&lt;muvgruv

�</text>
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                    <text>.‘u.

7“,. wwn—QWW...‘

F‘W.¢~w.ﬂ

».

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,

,

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.

27w,“

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-&gt;

K’VW‘rVarrn-ﬂ‘

December 13, 1967
Dr. A. Arthur Sugerman

Chief, Investigative Psychiatry Section
c/o New Jersey Neuro~Psychiatric Institute

Box

1000

Princteon,

New

Jersey 08540

Bear Arthur.
Both Don and I have January 12

Princeton.
I

look forward to seeing you

set aside for

at the

a

visit to

ACHP.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>l9 September l97l
Arthur Sugerman, M.B.
Neuropsychiatric Institute
Princeton, New Jersey

A.
NJ

Dear Art,
has been a long time since we chatted about ECDEU
reading
affairs, or about stocks, and I was reminded of thisin in the
addicts
in
narcotic
on
recent
prazepam
report
your
Journal of Clinical Pharmacology. I found your report interesting

It

for it confirmed some of our observations with tybamate in a
similar group of subjects. We had tried to maintain patients on
tybamate during the post-drug withdrawal period, in the hOpe
thatbb tybamate would 'block' the craving for opiates and reduce
recidivism.

Unfortunately, our patients liked tybamate itself,
that
particularly when combined with alcohol. They reported
small doses of tybamate and small doses of alcohol acted

synergistically to give
can do

them a cheap

'high‘.

So far. there seems to be little more that we
for the Opiate dependent but reduce their symptoms

during withdrawal, or maintain them on methadone indefinitely.
the antagonists show these
still believe that our workwewith
have had difficulty in convincing
drugs to be most useful, but
the authorities that more efforts should be spent in this area.

we

My

best regards.

and

my

best wishes for

a happy new

Sincerely yours,
Max

Fink, M.D.

year.

�</text>
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                    <text>October 11, 1963

Sugzm
War
New Jersey Ihmychiatric Institute
Dr.

Box 1000

Primeton.

New

Jamey

Boar Arthur:

Itmapnumpmipaﬁnginﬂlemtingninf‘mmw
Imtakingﬂnlibertyofamloaingaaopyoftm

withyou.

who is at the present times,
cmiwlum vitae of Dry. Serafetinides,
desire
to come to this eomtry.
a
at the Mandalay and has indicated
sand
a
copy of the complain £110
you
I will
If you are interested.
and will write to him indicating that I have sent thison to you.
My

best regards.
Sinaemly yours.
Max

Fink,

Director
MI-‘xam

we.

M. D-

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                    <text>October 1a, 1953

m: Jersey Sum
Neuropsyatﬁatric Institute

Dr. Art-Imp
Box 1000

Princeton.

New

Jam-y

Dear Arthur:

Immmmngﬁwapplicatiomamﬁndﬁutinmadingtm,
with year estimates. I muld be wateful if you would indicate
I
Dm.
to
Saith. Section. Dan and Fulcahy that similar reward-1 Opportunities
ta your own exist at this Institute. It is apparan'c that I». Seymour

m

muldbeafimcandidatomdﬁmshe mapplys, ifatthattimyou
m oppm'tmity for her, I should be

grateful for yaw recommendation.
I should be very pleased to hear I'm any of these candidates.
321:
be
of help to imieate that this is a new
my
warmer, in
mtmpolitan St. Louis, with pmg‘ams affiliated with the Washington
mimsjay Sdml at Medicine. I don‘t think that
detail would
be macaw mm to state that we have a. mm in the Midwest vary
similar to yam in New Jér'sey.
have:

.

mm
m

Han)!

Khan
0110.

thanks.
Sincerely

yam ,

Pink,
N
Direct):-

M. D.

�</text>
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                    <text>October 21, 1953

Sm.
mist. Investigative
of
in

A.

Arthur

8mm

H. D.

Paydmiatry

Research

Hemlow

Paydliatry
c/o New Jenny Hem-Psymiatxic Institute
and

Box 1000

Primetm.

Nan Jamey

Dear Art:

Mrsepam‘temr.1mundingymaaopyofthaold
bibliography.
been mvisad. The revised version has just
to the printar and

misoopyhunmmenm.isinmta.wm
30mm
Water
withmmodfwmwillbaoffﬁnmby

Withuaatdtommenhipintmm.lahmldbephmed
main: two a as. and if Carl Pfaiffar
Whip
wandahomcmendyw.ﬂmnmmdan
to spanner you.

Wmmmita
mating. Wouldymplaasaaandmaaeopy
Wmatmﬂmary
ofymmnimnmdmsomtlwmtamwhm.
IahanbeattandingmmrDmatinminnam. Innmadtcmiromldphntoviaityoum'mméay.Daoanbars.
y

atom.cola'smqmat.itwou1dbaholpfu1totmcnnim10w

Phaehtmmifﬁxiadataisutisfmtwymdlwinaakmof
joins».

mPSCItafthe
ﬂy

but

mm.

Stanly

yours.

Ha: Fink, H. D.

Dimctor

Hleg

�</text>
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                    <text>December 31. 1963

Arthur Sugerman, M. D.
Chiof , Investigative Psychiatry
Bumm of Womb in Neurology
and Psychiatry

A.

c/o

New

Box .1000

Jersey Mum-Psychiatric Institute
,

Princetm,

New

Jersey

Dear Arthur:

I would be. pleased to have you visit the Missmri Institute
of Psychiatry to participate in the Residency mining Program on
January 33.. A tax exempt mmip’c is enclosed to permit you to purchase your air tramspor'tatim tax free. We will
the ex—
and
of
honorarium
visit
provide
an
penses
as well.
your

mime

if

I would be pleased you would discuss with the maidensts
some aopoot of your experiences with new drug , highlighting,

if

possible, the problem of new drug evaluation in the Woolly
and giving them an evaluation of soda ompomds as you have
ill
found useful. This is part of our effort to provide the staff

m.
associates

with different viewpoints mgaming peydwtropio

I will extemd an invitatim to my own
and look forward to having the oppornmity for you
timing the afternoon.

I

.

would be pleased

31138th

as well.

to met them

if you would care to stay

over night as

foryoutomtumtoﬂowYozkthemxtmng.
Them am two flig-ats leaving Idlewild ovary naming, at 9:15 and
9:45, amiving in St. Innis at about 11:00 am. If ya: will let us
lemma: flightymamtaking,wewillarmngotohm
my

Wmt

Yong.

by best wishes

for the Nw Yew.
Sinoemly yours,

3me

Max

Fink,

Director

M.

D.

'

�</text>
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Max

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                    <text>7383w505A

January zhth, 1973
Richard M. Suinn, Ph.D..
Professor ana Assoeiate Head.
Department

at

Psychology,

Colorado_8tate university,

Fart Collins, Colarado

80521.

Dear Doctor Suinn,

associates and I are plcauad you are
eonaidering our report for the book of readings titled,
My

"Innovative Therapies: Critical Contributions".

I am enclosing tha signed release and
of the reprint you requasted.

two copiea

that report was written as have uycated our
experience. and I am encloaing two capiea at the latast
Since

version of our reyort on thesg therapies. This varsion
has been submittad for publication, but has not yet
ammearod. I am confident that V» can dbtain a releasa.

I

that you an not aonsider rqyaltiaa tar
our aontribution. at the least I wauld axpect an ed1tor~
signea copy of the final publicnﬁion for each of the
authors. I trust that this vould be possible.
While

meta

gingerexy yours,

Fink, M.D.
Erofeasor of Psychiatry
Mb;

MF/id

Baas.

�</text>
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                    <text>w... .y.

v-

-n-r 41"":var—-.-»-

‘-'."l-W-»~-wn1—

vawl-Vr."wanna—mm

a“‘|&lt;'&gt;V—-—'V'—-wlr-WW'V‘VWWW‘thru—IW‘

"Hilly-\r'wrrw"mt-.‘n

,

”m..." Wy-..“

a. ..

mm

.wnww,_,.;._r_.vm.r

WM”

rww’NWHv-w

rum.

4.

October 16, 1975
‘ﬁ-VPFEIWm-vrw‘

v.
&lt;

.

Richard

m

V.

.J

M.

Suinn, Ph.D.

Professor and Associate Rhea
Depertnent of Psychology

'WW‘

caloriﬁc 8$e$e University

ibrt Collins,

vs

Colorado 80521

r--r‘&gt;—'1.I$Vt

WNVr-‘v

Deer Dr. Suinn,

In checking
you requested pernieeien

my

records I find them e few years ago

to reprint

one of our papers on

narcotic

entasoniate in a volume ”Innovative Therepiee: Critical Contri-

butione."

I don’t recall seeing the book,
ask whether
whether

we

and

this publication did indeed appear;
may have e copy for our library?‘

I

em

and

writing to

if

so,

Sincerely yours,

ma, “0of D.Psychie$ry
m
Protester
MFYur

‘

~wﬁ

w...

.V,

“7......

w

�a
‘
‘

‘

r v.

w?"

w—.

~v.

nun-7r,-

"urn-WWIV

v.
‘

&amp;

am..."

V

”wwwmmmﬁ

WW...

v

785-5055.

January

236th, 1973

8m.

31311“ M.
Phoni.
Profbcsor and Assaults: Head,
Dapurtnpnt of Piyuholoar.
Colorado

Silt: university.

For: Genius.

001m

30521.

Dear Doctor Evian,
Hy associatns :nd I are planted that you tr.
‘.
considering our report tar tn: boat of readings titlad
”Innovnxlvn Therayict: Critical Contributidns”.

I u: enclosing sh. signsd rolonn¢

of tun rcprint you requastcd.

and two coping

Since that report‘vna written v: have updtted our
axpcricnco. 3nd I nu enclosing Eva c0910. of thc latent
varsion of our report on these therapies. This varslon
has beau Iﬁbulttod tar pdblieatian, but has not ynt
tpwoarcd. I an canfidnnt that v» cgn dbt;1n s rolonso.

I nut. thaﬁ you ac not considnr ruyultioc 2b:
aur contribution. at the laalt I would oxpcct an editor»
ligand cony of the final publication for each of thy authors.
I trust that thin vauld‘bo’ponutble.
While

Singercly yours.

Mn:

rink.

M.D.

Profoaadr of Paychittry
10/13

Incl.

�</text>
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                    <text>“.4

.
,-,

_

_,,_w&lt;,,_,,,.c..,..,,

.
_
A

I

February 27. 197“
Coataa Stefania, M.D.
Eginition Hospital
Thens, Greece
Dear Costco,

before the

APA,

Enclosed is the

official

acceptance of the report

to be presented in Detroit

I

invited to

on May 9.

first
of April, and should be free on April 11 to come to Athens
for as
many day; as it may be useful. I should have the results of the
ongoing analyses with no at that time. If that period is convonlcnt
fOr you, I would like to moot with you and to work to the extent or
the time available to us, anticipating completing the discussions
in ﬂew York than you cone some weeks later.
have been

Europe

for the

ten

Is that tins convonicnt {Or you ? (If not,
defer our meeting: mtil you cone to the United States.)
no. In

If it is, I would like to bring
that agreeable to you 7
my

we

can

Dr. Dornbuah with

boat regards.
Sincerely yours,
Max

days

Pink,

14.1).

�</text>
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                    <text>March 21, 1990
Fridolin Sulser, M.D.
Vanderbilt University School of Medicine
AA-2215 Medical Center North
Nashville, TN 37232

Dear Fridolin,
am particularly pleased to nominate John M. Kane, MD. for
membership in the CINP. John is now the Chairman of the Department of
Psychiatry at the Long Island Jewish-Hillside Hospital Medical Center. am very
well acquainted with his work from his training with Donald Klein (1975-77), his
leadership of the Research Department of Hillside Hospital (1977-1987), and his
active membership in our Department of Psychiatry at Stony Brook (1977-1989).
I

I

John

is a dedicated clinical and theoretic

researcher with special

interests schizophrenia, antipsychotic drugs, and tardive dyskinesia. His
studies of the relative efficacy and safety of high and low dose fluphenazine
provide the best data on dosage, efficacy, and safety of antipsychotic drugs.
These studies led to prospective studies of the incidence of tardive dyskinesia,
and here again, his studies provide the most substantive data on the incidence
of TD, and the risks associated with dosing, time of exposure, age, gender, and
diagnosis. With Herb Meltzer, he is a principal investigator of the efficacy and
safety of clozapine in therapy resistant psychotic patients and is credited with
convincing the FDA to re-introduce clozapine in clinical practice. Finally, he is
the principal investigator of an NlMH clinical schizophrenia research center,
which is carrying out useful clinical and laboratory studies of a well studied
cohort of schizophrenic patients.
in

He became a full professor at SUNY at Stony Brook in 1985, an honor
that is sought by many and achieved by few. John is a fine clinician and able
administrator. His publication record is excellent and his standards are the
highest. His promotion to chairmanship provides him with one of the best
clinical services for research and am confident that he will continue to make
important contributions to biological research. He is a consultant and leader at
the NlMH, ACNP, and the American Psychiatric Association. I commend him for
membership in the ClNP with much enthusiasm and without reservations.
I

My

best regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

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                    <text>rvvt—U‘m-z-"w~.-; \

wx—y. ,-

ma «may, we uwtv mm: D, ."wvlu , ‘--.4.&lt;w,w.q..-wu«.¢\~. .wo-uapm m.)- Avid-'nxuw.’"—9,. I'w'.‘
-

my V11 ~»y

yum\ 3'”m y—m .w “my“... man a...“"jumpy.
».

nu,-,..w...ry~.u.wm.yv(u~——~—my

mar—“munww

.

.e

(v

y

-,

7:7,.»

,.

September 16, 1976
Mr.

Philip

G.

Sunderland

1908 Sunderland

Washington, D.C.

fiace

20036

Dear Mr. Sunderland,

material that you requested in your letter of September
13, 1976 will require some work-- to summarize the reports and select the
references. We would be glad to undertake such a review at the rate of
$lOO/hour, with an estimate of $0 hours for one that may meet your needs.
I trust that this will be acceptable.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

~~( «rc‘ a.

..

'1'

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19:

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I should 11k. to mitt. out Mata-tuning hurtling you: assignmats following tbs tat-lust“: of Dr. Gsﬂisld's tethitiss hats.
Your stsdlss in nation tins in mjmttlon with ths various
fanatics sad than” mists»: prajstts will mums and
huh
should
about 508 a! your tins. In this «auction. I
would to plsusd 1: you would sspsrvlss sad psrtttlpsts in th
nudist of Mr. hssvitt. who is projsetsd to dsvsloy studies is
tbs
task in mjmtton with an: bruit

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studies.
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                    <text>October 25, 1963

Baum

115

H.

Smdland, Phd).

“catfield

Rand

Knoxville 19, Tamasm
Dear Dr. Smdland:
I

Ram

(W)

I m pleased to appoint you to the position 01’
Sdmtist
at the Missouri 13921th at Psychiatry,
effective: on 61" about December 15, 1963 at an mun}. salary
of $10,620, and such additional perquisites as the State of
my, from tiara to time allow. 'Ihis appeinmnt is
”*1st
thn mks af this Hiesmi Nari-t System.

W

I

look

Witt: your joining mm staff.

Sincerely yours,

Wm:
ac: Dr.

891

Garfield

�</text>
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                    <text>June 12, 1963

Swinmndent of mounts

@0th Printing Office

Washington 25
D. C.

boar Sir-z
\\

is computed order blank requesting one copy
of the
presented to the Oomittae on
MEN: asAlso
Scienti H33?
0
enclosed is our chad: in the
arm
.
of $1.00, of which 25¢ is to cover cost of the
publication. We would like the remaining 75¢ retumed to
us in the form of GPO coupons.
Enclosed

mat

Please mail publication and comm to the Psychiatric
of Missowi, addmssad to my attention.

Research Foundation

M We

Sincemiy yours,
D.
m
m. H.WorMutive

Mijr

�</text>
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                    <text>Emmy 30,

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                    <text>November 13 , 1961‘

Professor Nozomi Suva
Director of Hddcaido University Hospital
Sapporo, Japan

Deer Professor Swa:

‘

Health

at

Dr. Kama Saito

of the

Department of Public
of Medicine has
this research and train—

Hokkaido University School

applied for an appointment at
ing center as a research fellow in nemphysioloy.
He has suggested that we write to you for additional
information.

would be grateful for any cannmts you
to nuke regarding Dr. Saito's experience, his
ability to relate to his coworkers, and any talents
that he may have exhibited during his experience with
you. As you may guess, we are particularly interested
in his ability to relate to nembers of mar staff, so
determinate.
that his language ability is an
Insofar as the programs in research at this
center are dedicated to evaluating the changes in
brain physiology associated with various changes in the
treatment process of the severe mntally ill, much of
Dr. Saito's work will be in clinical and experinental
electroencephalomhy. Any comments that you may wish
to make regarding his ability in this type of work

my wish

We

‘

'

_

Wt

would be appreciated.

Thank you very much

for your cooperation.

Sincerely yc‘mrs,
Max

Pirﬂc, M.D.

Director

mf/ ls

�</text>
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                    <text>u

w‘r’ﬂ‘lw-‘Wymxw'vv-‘WHW-‘lm‘1"?!Wimtlri ' m;m1m "w.

.Mzr.

,

,

,

.

,

7

.

‘

u

w!“

-

,

—..

June 7, 1965

11'.

Jean

mm:

M.

Swain, 11.1).
of Mental Hygim

Amws Stat: mspital
Sen Joan. California 9511“

Eur

Dr. 8min:

new
letakingmnbwtyofmlmingafwthat
law may Mm purchased fm this. laboratory a3 well
u the mmry statemt which appum in an mick
publism in 196“.
I

has,

am

not sum ”ﬂatly which pmnprint Dr.

Thank you

fw your intmat.
Sincerely yum-s.

m
M; of Psychiatry
manor
HOD.

fojm

.

_

“wwuvwvwwww

�</text>
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                    <text>July 5, 1986
David W. Swanson, MD.
Section on Psychiatry
Mayo Clinic
200 First St., S.W.
Rochester, MN 55905
Dear Dr. Swanson,
I

read your interesting report on the Soviet viewpoint on paranoid disorder

latest issue of the American Journal of Psychiatry with much interest. I was
particularly struck by your comment that 'in the best controlled (treatment) study,
in the

computer-assisted multidiscriminate analysis of the EEG was used to monitor
pharmacotherapy'. The author was cited as Alimkhanov, and the citation indicates
that the original article was in Russian.
1 have been
using quantitative EEG recordings to assess pharmacotherapy
for many years, and l have been unaware of this author. 1 would like to read this
report. Was it translated for your use, and is such a translation available? 1 would
be glad to defray the costs of duplication.

Thank you for your help.
Sincerely yours,
Max Fink, M. D.

Professor of Psychiatry

�</text>
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                    <text>7383-531

hbmry 15th ,
Dr. Donald A.

1973

Won,

6:- Stun-doe Avenue.

Rosetta,

Jobmnubwg.

Transvaal. 6mm: Airing.

.&lt;-‘

7-

wow”

wngr-

Tow

~14»

"WW”?"WF‘W

Dou- Doetor Simmons.

I m delighted that you will be 30111113 us and look
fawn-d t0 muting you about. Slat-eh 6th. Fret w diminutionwith Dr. Brinenden and Dr. Don, the various mangmnts
for your migration seem well in hand.

V,

v

t
,

I meant“

the highut priority must be given to
tha sustenance of your mum and we will do everything
we can to assist you. I believe ycur initial
will
be in conamction with our newly established
11:
drug shun. We will mango for some training and I
mtieiyuta that within I. run mum you will be «part
in the
or (mi-tea dependence.
than:

«31M
Wm

mmnt

I look {mud to meeting you aid your family. I trust
United stake: will In uneventful.

year flight to the

smears): your. .
fink, MID.
m
hotelier of Psychiatry

s

29/13

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..

v...“ or... .9.» awnwwu

’

&lt;anr-nnm

May

hiss Janet

25, 1970

Swanson, R.N.

Division of Nurse Education
New York University
New York 10093

.

Re; Daveeda 8. Ross

L

.

Dear Miss Swanson,

I

am

pleased to submit this

for additional nursing training at

New

letter recommending ﬂies Kass
York University.

Miss Ross joined my staff early in 1969 and undertook
special training program in electroencephalography. She soon became
experienced in this technique and exhibited sufficient independence
and interest to asSume responsibility for studies in normal human
volunteers, In these studies, normal subjects are given novel
psychoactive drugs and the nurse (technician) and an assistant record
and evaluate the behavioral and physiological effects of the drugs.'
In these studies she has acted very much on her own and has yielded
interesting and reliable data.
a

'

She has also assumed responsibility for a drug evaluation
in anxious psychotic patients, completing the usual evaluation forms
and maintaining records, interviewing patients and summarizing the data.
In both these activities she has shown a sensitivity to small behavioral
changes and maintained good relations with the subjects, patients and the

staff.

Daveeda is a cooperative, pleasant, enthusiastic and bright
nurse. She has made important contributions to my programs this year,
and I would be reluctant to.lose her participation. I recommend her
highly for additional training, in the anticipation that I will be
able to enlist her assistance in my programs in the future.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
mf/

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Ww-y.w~.m

June 3, I9 87
Conrad Swartz, M.D., Ph.D.

Department of Psychiatry

UHS/‘i'he Chicago Medical School
3333 Green Bay Road
North Chicago, ll. 6006!;

Dear Connie,
Thank you for sending me the videotape of your unusual interview on the
demasculinizing and cardiac effects of chronic alcohol use. To the long list of other
reasons which I have dutifully expressed to the students about the hazards of
alcohol use, lcan now add these data. The argument that alcohol use contributes to
myocardial infarction is another compelling one for the anti-alcohol lobby.
Two decades ago, similar questions about demasculinizing effects were
raised about cannabis use, mainly by Gabriel Nahas. l have often wondered whether

these reports have merit. Is there any data on cannabis use and myocardial
infarction? A question to Costas Stefanis at the University of Athens may
encourage a parallel study in chronic cannabis users.
am so glad that I am not an alcohol user, and when
your ﬁndings, she was also pleased.
I

I

told Martha about

'

Keep up the good work. My best regards.
Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

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:i

Cumming Center

a,”

13*: 2.384133 81:.
New Orleans 12,

lauisim

Dear Jim.

Aspartofourpmofdatnpmantatim,mn3hapim

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mllaxlwuhambunmtiﬁodwiﬁxmofthedatawhich
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ﬂunk: for yam support.
Sincerely yours,
ﬂax Fink, H.D.

measaor of Psycmatry
01:01am

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Dr.

Jane

New

Drums,

1965

w. Sweeney

Tulane Bio-Medical Cmputer Gentcr
Tulane thivemity School of Main:

Wain

Dam Jim:

Immadingthe latest isaun okaMgazinewiMnI
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mmmmmmlymmmdmfwm
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hawmoppwtmitytoactinsa
My

congratulations.
Sinmmly yomm ,
Max

Firm. ELI).

Professor of Psychiatry

Mfﬁcp

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                    <text>January 26, 1968
Dr. Bernard Swerd10w
336 Third Avenue
Long Branch, New

Jersey 07740

Dear Dr. Swerdlow:

Enclosed are some of the rating forms which I d1str1buted
lecture last year. as weli as two in use in our c11n1c.
which may be of interest to you.
1n the

Thank you

for your inquiry.
Sincerely yours,

m.
um

72a»

A
.

Fink, M.D.
Professor of Psychiatry

Max

vary!»

;

‘»
«r

Prat:-

rat-17.

,‘YMKJﬂfhh

’;‘!-'u

r'

me‘&amp;ﬂs:w‘mmw

WW-

.z"

g

Mszp

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                    <text>«W ~Wmm “Wmmrs... w"? m
m

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.

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V.m —”9‘. r...-v .v-v—vmw—v-—-.—

~7-

7333:0h23b

E

ﬂ",

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w.

..

12 February 1973

-‘-rmr--v-—mwr'pvwr-m-.Wr

Dear Dr.
W”,

w_,__.,,",

Svint,

E

May we have a copy of the 'Internationnl Registry of
Y
Enclosed is our check
Users
among Psychpphysiologistl'
Computer

for $3.00.

N.

.

..._._

Thank you.
mum—w...

Sincerely yours,

w'

mum-«r

‘n‘ﬁv-tw’:

Fink, M.D.
Professor of Psychiatry

Max
'QFWW/Avw:

‘N-

w-

w

‘

E

Emmott B.
Box 3119b

Georgia

Svint

Institute of Technology

Atlanta, Georgia

30332

1

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‘Ihe Honorabla

'23

, 1966

Stuart Symimmn

United Statas 86mm

Washington, 9.0.
Dear Mr.

SW:

I wmld be grateful if your semtary could make available
t0 my office a copy of Public W30 mien we have been told
ascribes the proper use of blocked funds in foreign mummies
has an
for 12535161 and teadﬁng puma . ‘mis
with
the
in
invest establishing a msumh 13mm
mimity
of Istanbul and

we

would be

Wt

Wt

gratiful for any information I!»

gardingthia lacorﬂnproperofﬂoes inthe State
Mlpm to us .
man}: you for your referral.

which my be

Sincerely yours ,
Max

Pink, HA).

meessor of Psydmim

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                    <text>,.
.v.

._

...~..

-

(—7»

~&lt;—.~'v'a"_

73SB~756$B

13 Hovembor 1973

H. C. B. Danber. M.D., Ph.D.

Pro£cuoor of Psychiatry and Pharmacology

Callas. of

Modicino

Milli: Health Cantor
J.
Univlroity at Florida
H1111:

6:1nsnvillo. Florida

32601

Door Hy:

can to

York, I “locum! tho publications which
paychepharnooology from 1956 to 1967,
for
I felt were important
I am enclosing
of
psychopharnacology.
in
my course
a: part
no
an
v.11
additional
tho
an
of
group nines 1967.
a copy
reprints
when

I

Row

were to focus an I3 principal interact: in psycho~
pharmacology, the davnlopmant‘of quantitattvu EEG methods for
classification of drug: would have to be my principal contribu*
tion catamaran.~ From the voluao. you will no: curly papers
from this point of viaw, and sons of the later raprinto will
.

If I

bring the information

up

to data.

anothot point of View, I have always felt that con—
vulsivc therapy was a complex way of proviﬂina portintcnt bio»
dhaaicnl chanson in the brain for thoir boh:V1aro1 effacts.
2 In oncloaing a ﬂaw raprinto from :3 BOT axpcriuuco, particu~
ltrly tho cholinnraie hypothesis, for those may also bu tale»
van: for a rovicw of poychopharnacoloxy.
From

Finally, the'principtl focus of intoraot in How York has
boon tho duvelopnnnt of narcotic antagonists, and I am enclosing
a xnroxed copy of tho report whioh I pruparoé for the Marijuana
Commission in Soptoubar. 1972. This will 31?: you, I hops. an
overview of
My

mvwc

this spoaialized braaoh of psychopharmacology.

bust regardb.
signeruly yours.

.‘——-

'“W’mﬁt‘rry

:4». Pink,

um.

Professor of Psychiatry

‘mw

Noun

MF/cin

�</text>
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2‘ January 1974
Coatee Stefanie, M.D.

Protector of Peychiatry

University of Athena School of Hadicine
Eginition Hospital
74,

Vaaoillisaia Sophia

Athena.

Avenue

GREECE

Dear Contae:

I have tried to reach you on a number of occasions and have
failed, eo I on writing to give you a progress report.
The withdrawal data are now in the stepwise linear regression
analysis phaoa. As Aria Linton will tell you, the more relationfind. the more additional analyses
These are progressing, and I ehould be able
of the obaervationo in about two weeks. So
to attract effects that could be related to
ships

we

of haehioh use.
Beoauee

seen to be noceaoery.
to send you a summary
far, on are not able
the discontinuation

I have been required to submit a final report to the

contracting agency by January 31, I have submitted a summary of
the data that we have had on hand up to tho fall of 1973. I am
enclooins a copy of my covering letter and, separately, I have
nailed the summaries that we submitted to fulfill tho contract
requiremente. The aunaariea do not bind you or no in any way
with regard to future amendnont, publication, or presentation.
These reports are not public and are not considered publications.
although the NIDA staff may summarize our findings in their raw
ports to Congroea. When your summaries are completed and integrated with tho findings of the withdrawal atudy, we may submit
an amanded final report to mini. The publication of a volume
describing our oxperioncao would be a more fitting culmination
of those effortl.

I have requested another extonaion in time to provido you
with fuodo to visit the United States. I do not know what action
Dr. Snare may take. but I will write an soon as I know.
Ho

have revised your auggeotiona regarding publication

and presentation of this material. I not with Professor Freedman
and he called the Program Chairman of the American Psychiatric

Association.

A

preocntation, provisionally entitled "Chronic

Haehiah Doe and mental Disorder."
.

-1.

will be

on the program.

�Because an abstract was required immediately, I wrote one. A
copy is enclosed. You will note that the conclusions are vague,
and this will allow you to write what you believe to be true
as the data unfold within the next few weeks. Should you dieagree with the list of authors or the sense of the summary. I
would be grateful if you would amend this immediately and send
back to me by express.

it

we agree with the two other suggestions for presentation
in your letter of January 3. I have asked Drs. Dornbush and
Volavka to summarise the quantitative EEG and heart rate changes
for a report directed to the Journal of the American Mhdical As~
satiation. As soon as this is prepared, I will send it on for
your approval. I assume that the EEG findings will be written
by Tom and that we will have a chance to see a draft. A paper
on tolerance to cannabis should indeed be prepared, but the data
of the withdrawal study is important for this report, and until
these data are digested, this report be delayed. The study of
psychophysiological correlates of cannabis should be written,
probably by Aria Liskos, and we would be pleased to assist in

any way

that

we

can.

To close the books as of January 31, please submit state~
cents for the balance of the funds which have been allocated
for the subcontract. I would hope that you have expanded all
the money by January 31 because we cannot carry this funding
forward. Should NIDA allow an extension in time, we are prepared to support your visit from the remaining funds allocated
to the 8.8. portion of the contract. I do not know how much will
be left, but should there be funds in addition to the amount necessary for your visit, we will nuke these available to you for
continuation of the work to the termination of the contract.

It is

a pleasure to work with you and your associates, and
on the summaries which we have dis-

I look forward to working

cussed.

.

Sincerely yours,

m Fink,
MF/cis

Encls.

MOD.

.

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                    <text>7M6”
Dr. E. 3. Terry.

Nadia-.1

Dinner

911m. Rum]: (Guam) Ltd”
250

W: Blvd. ,

wink-.0131”,

mutt.“

73°.

PnQi

Butch.
In line with your gut-Mon remains promnolcl ,
I have taut mum a must for c proposal from
um. «king 1! we would1nbe tutu-outed in undertaking
«tutu-s of mpmlol
opiate addicticn. Enclosed
this woman. It in
an three men rolmnt to
that snow bu decided to take aux-tonal:
”punt
the work of Dr. Kama ﬁrst: or Indimpolia. My own
or Dr. Grou’
in that it doe: not Justify
“that.
extensive work at this time. I believe that he should
be same“ to do some “tench. audits to Justify
Dear

an

his claim of

anemia afﬂmy.

I trust thia is of tone tutu-Mt.
Binamly yam-I ,
Fink. Md).
m
Professor of thutry
30/13

�</text>
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                    <text>7353—662

Key

Kety.
SW
Jeane: new,

1.

1973

14.1).
1711.1).

Min Ken, NJ).

Deer Seymour. Jim, and Martin,

I hue received an «gushed plane cell from Tom
William in response te w letter announcing the full
ennui-110:1 of the articles from the meeting to the
publisher. He enquired u tn whether indeed he "had
been and from the editors". Hot knowing how to respond
mediately. I indieeted that I ma consult you.
I do not recell the compact which Tom is referring
that in editing this velm we did not
to. I do

m

that, in truth. his pertinipetian was
limited to representing the Clinical Research Breach
at the program eeuim.
«1.1 on him end

If there

in e

mi: which I

may be

neglecting,

grateful for e ruinder free any of you. In
the ebeenee of each In reminder I would be inclined to
learn the
u they ere. I an grateful for

I

would be

m

mwnte

advice.

sincerely yours.

Fink, HJ}.
Profeeeor of Psychiatry
Mu:

16/13

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                    <text>October 8, 1973

Peter Siegler,

K.D.

Htrrell—Nn$1onal Ldboratories
PO

Box 8203

Philadelphia, Pa.
Dear Dr.

19131

Siegler,

Octdber 3, I subaitted a revised page 8 of
our protocol. dated 6.26—7h. That revision was incorrect and I am
enclosing a praper revised capy at page 8. Please destroy tbs one of
last week and substitute the enclosed page.

In

my

Many

letter of

thanks. Our work is proceeding wall.
Sincerely yours,

Fink, K‘D.
Professor of PSychiatry

Max

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                    <text>-

October 25. 1967

Dr. H1ll1am laborl
Rob1ns Company
l407 Cummings Dr1ve
; Richmond, V1r91n1a
A. H.

r113":

(Béar

&lt;._,.

7—“

Bill,

~

Enclosed are the completed study protocol pages and
supporting documents for the study of butaperaz1ne syrup.
as maintenance therapy 1n chron1c schizophrenic out-patients.
I am enclosing copfas of the _USPHS forms as we plan to use
these 1n th1s study.
,

Thls study has been approved by the appropriate committees
of the New Yerk Med1cal College and I hers only to awa1t the
usually a matter
approval of the Comm1ss1oner of Hosp1tals
of two to three weeks. The Study may be undertarken at that
time or as soon thereafter as we have rece1ved the butaperaz1ne
—

syrup.

W staff has made Some suggest1ons regard1ng the type
and 51ze of bottles that may be necessary far these patlents:
May I ask that you send us a small supply, enough for only a
few patlents,1n1t1ally. As soon as we have had some exper1once
1n del1ver1ng
l1qu1d med1cat1on to our patients. 1 wOuld than
_l1ke to be able to d1scuss w1th you the amount and form of a
more def1n1t1Ve supply of the Syrup.

1'

a

&gt;

‘

Thank you

has called

It

me

.

for your asS1stance w1th Tybamate. Dr. Fernandez
and I have alreadysent h1m a copy of the protocol.

was good

to have you vis1t us.
S1ncerely

Max

F1hk,

My

best regards.

yours,
M. O.

‘

9rofossor Of Psych1atry
MFEkp

�</text>
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                  <elementText elementTextId="102280">
                    <text>,.

,7 w

,.

.

,~

'7)" ,7. u,

~

ﬁnnw'wa-vw'v---w.v-vw-o;w
‘mumzrrmmavmr'gmwwgmmwwv&lt;wvuqv-«vzmwvww:mnw-rwv—rw
-

E

.

.wzmr-wra

‘

,

”‘1'me

,

'

{”3“

E-

E

E

w

'ww'l‘nvv

October

'

v-z-‘er-rv

v—rw—

”Wm-ﬂ

1967

Dr. Willian Tabor

Dear Dr. Tabor:

Enclosed

is the study protocol and statement of investigator

for the fenflxmanine study.
As

awn as

I

have received an

initml

Iwillbepleasedtostaxtthiaatudy.
I am also enclosing a
mung forms.
_

few samples

supply of fenflm‘mm’ne

of the self and investigator

Sinmly yams ,
Fink, M.D.
Professor of Psydxiatry

Max

:m-«v-mu-m—vmn»

"Wu-P

vgwtmv :mvuq'umn-wwrW-unwnmmarvm—v-v---:-v-

A. H. Robins Cmpany
1H0? munings Drive
Rick‘smnd, Virginia

mn-vvv

1—,",

2*},

-..w~.»v-x'-chn(

Mszp

w-w-I—v—w-w—rv-rv

.

�</text>
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                    <text>Ianuary

Dr.

14,’ 1972

Hilliaa Tabor

A. B. Robina Company
1407 Cummings Drive

Richmond, Virginia 23220

Dear

Bill:

Enclosed are two copies of a protocol to assess tho
level, and behavioral effects of the formulations
of butapcrazine; and a copy of the curriculum vitae of Alexander

EEG,

blood

Don.

will request supplies of both cone
tablet butaporazine, and a small amount of placebo
of either formulation; your willingness to file this protocol
contrate

In the study,

and

we

as a supplement to the concentrate IHD; and the cooParation of
the laboratory ~ to assay the blood ramples for butaperazine

levels.

Dr. Don was

my

student in Hiaaouri. no taturnad to

South Africa to raise a family, and than emigrated to the U.S.
in Nova-bar 1971. He is capable, and interested in the special
problcna of drug availablility. For this reason, I posed the

quastion of this protocol.
The study

will

be reviewed by the appropriate insti—
and should be ready to begin by

tutional authorities shortly,

nid~¥abruary.

to Jaca

Many

thanks for your teaporation and

and Fred.

my

best regards

Sincerely yours,
Fink, M.D.
Professor of laychiatry

Max

Hrzig
Enc.

�</text>
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Q
2’

January 28,

931115.33: R.

Tabor,

M.

A. H. Robim Oanpany,
11507

We

Drive

\J

196%

D.

Inc.

Edmund 20. Virginia

Dear Dr. Tabor:

butapamzim has been progressing nicely
an abstract of
md
Itil Keakiner have submitted
Osmium. A copy of
their observations to the C.I.N.P.
that abstract is enclosed for your infmtim and for us: within
your
Our study with

and recently Dra.

my.

We

.

look forward

to your visit to our laboratories.
Sincerely yours,
Pink,
,m
mmetor

Wzmlg

Enc. 1

M.

D.

�</text>
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                    <text>May

Dr. William 3. take:

A. H. labia: Gummy,
1607 6min” Drive
Richmond 9.0, Virginia

best be.

8,

1966;

Inc.

rm:

Thank you very much for your latter of April 29, which reached at
this morning upon my return from the APA mating. Both 9:.
3nd I had 3 very pleasant visit with you and
surf and upon
asked
pmtoeoll on
our “$061!“! to
our return, we hm

Itil

mr
mitt.
ﬂat first block of patimta with hutapemim. Thou protocnlt
and they will In “at ta you u «an a
an new Ming pnparndBoth
the tunic“ protocols and thc laborathey an minted.
tory

inlmtim will bu

During :50 next few

mks in will the

for our atom! stuﬁy.

request: covering,

Iine studies.

submittcd togethar.

the»

couplets a

faml. protocol

that times. we will submit a study grant
costs of both the first and second bum!»At

“a ham Just been notified that sat «port on bututr-utim has
been weapted by the program tmittm of the cm (Collegim

Internatiamie merayehophnmwlogicm).
During thn APA muting, bath Dr. 11:11 1nd I met with Dr. banker
and In out. we plum tn hear that ha bl! coneumd in our
quttionu standing the pm: douse for butmruim . An in
indiutcd. h. «um! um: tho donut range for out-patient: Ill
20 and ‘0
par «lay, and {at in-patimta in ”mutt-it
tom:
n.
institutions, approach-Italy 60 :3. per day. We also met Dr. man.
an: of the world‘s outstanding paychophtmcalogists , and In empro-«d tht opinion that mgcptil nu indent! the mt potent psychotmpit drug. “though it had madman aid. cutout. U0 bclim

tint haematite 1. probably the next mt “native drug in
auto gainitophmit pmtic patina“.
w. will abaorb thu mat: of our trip to Richmond. It was I 91am

mating with you.

Sine-«1’ mu .
141/113

Fink
Ru
Director.

34.3.

�</text>
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                    <text>I,

Kay 21 , 1964

at.

ﬁber

"1111:: 1.

W

A. 3. Robin

Conny, Inc.

M»
new 20, Virginia
1‘07

Du: Dr. tuber:

”that:
and.»
1nd upon: ch. first plus. of

Enclosed are protocols on aim-stun
tuned with hutmrum 1m
August, 1963 to dam. and
o! ch: data. this intonation ha but:

put touch“ a. you: must,
study of thy inflame. o! heap-tutu. in thc tantrum:
and
”(barman mutant" psychotic.“

at

ch: luau: of
tannin;
that tho

13 our

a

9:.

30.1101- of Kay 14. 1963.

dine: costs for thin
known! the

Watery
Smllu

away are

a

follow:

11:

: two-par:
”that. chub-

«tint.

$2,500
1,500

studies {including m3)

-

Trml

-

‘ratnl

$14

.000

mm to continua tho study and the tax: phat. v11!
an
capmion of thin group to: includ- tmt-y—m are patina gamut
sud can nubto b. obumd 1n the am “mu-nut. using tﬂﬂwrmm or
jut:
chlarpmuiu. m ago: gram! :0: this part; at tho study and ﬂu

Va would

man an «cloud.
Ia addition, Br. Katina: has indium»! that. am:
supply of bun-v
11kt.
paralla- 1:111 in «mad within a month. and inpm»:
addictenal
mm
as follows:
study

gun:

mun

‘

Liquid

Omaha

In addition,

and

'1“

300

pints

2.000110 us.

appmiue n supply of monks tar ”mural m,
u would
m1“ at 10 us. “ch.

mm! 200

smear.1y your. .
KI! Pink, H.
lit/13

lac.

Hirsute:

D.

�</text>
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                    <text>June 19, 1964

William R. Tabor, M. D.
A. H. Robins Company, Inc.
1&amp;0? awnings Batista
RfLomond. Virginia 23220

Dear Dr.

Tm:

W

Enclwed are two checksﬁo. 85503 and No. 855%
dated June 3. 19616,
to the Paydxiatric Research
Foundation of Missouri in tha arms of $2,500 and $2,000
respectively. These are being returned fellowing our
cmvamtion. and are to be mimuod after the first of
July. Thank you very and: for your cooperaticm.
Sincerely yours,
Fink, M. DExecutive Director

Max

MFmoizbw

Enclosures

2

�</text>
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                    <text>July 9, 1966

Willitm R. Tabor. H.D.

A. H. Robins Company, Inc.
1407 Cummings Drive

Richmond,

Virginia

23220

Boar Dr. Tabor:
On

behalf of the Psychiatric Research Foundation,

Itil

his staff, wn wish to thank you
for tha favorable responle to our request far grant
assistance in our therapy evaluntion programs. The
£undn will bu used for the rascarch activities of

Dr. Incas

and

the Foundation.

Many

thanks.
Sincerely yours.
Max

Pink,

N. D.

Exccutiva Director

tar/31:

�</text>
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                    <text>November 30, 196“

R. Tm; Man.
“:1le
A. h. Robina Many, Inc.
N07 Gunmen Rive,
Richard. Virginia 23220

Dear Dr. Tabor:
Enclosed are three final draft copies of the
report submitted by 11‘. 11:11 and Dr. Keskimr to the C. LN. P.
in Septeubev this year. It is wr antidpa’cim that these
will be published in the forﬁzcmﬁng volume. Neumpeydxo»
pharmacology, edited by Dr. D. Bente and published by
Eleevier.

Simly yours .
Hex

ﬁnk, NJ).

Director

mf gla

enclwume

�</text>
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                    <text>March 9. 1966

Dr. William

R

Tabor

Ricrmnd, Virginia 23220
Dear Dr. Tabor:

m

copies of some additioml articles
m
and one which described the
action
prolonged
to
muting
with drugs.
problem of the faﬂm of patients to
I ma: mes will be helpful.
_

Enclosed

:2th

Sinmly yam,
Nam:

Fink,

H.121.

Manor of Paydxiatry

�</text>
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                    <text>1-

'I-"H

May

31, 1967

Dr. William R. Tabor
A. H. Robins Company
1&amp;0?

Cwmﬁngs Drive

Dear

Bill ,

Richnmd, Virginia 23220
w‘wvw‘

u‘
»

arm-«-

~r-.W—,-nrr-w

u
H:
v-zr:

It‘~M‘!‘.H’l-wrl'q

lnmﬂer-I-W‘rﬂr‘MM-m‘rw

Enclosed are three sets of the graphs for the preliminary
report on our barbiturate - stimilant EEG study. Please add
them to the end of the reports which you now have.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MF:]&lt;p

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                    <text>o'er:

row-:16“?!

WhW‘”

71%;}:-

I*W:‘mf'm~.§3‘i

Mey

29, 1967‘

Dr. William R. Tabor

A. H. Robins Company

We
Virginia

1&amp;0?

Richmond,

Drive

23220

Bill,

Dear

first draft of our progress
report No. 3 deewibing the EEG Wes with fenflmemine,
ambarbital, dextmmhetamine and placebo. We are enclosing
some of the tables to give you an idea of the material with which
Enclosed are three copies of the

we

marked.

I look forwazﬁ to having Mr. Pat Preston and yourself join
usinNewYorkabmtnomon‘Ihxreday, June 8.
In addition to the fenflmfemine materiel, I am pleased to
enclose copies of two depreeeion rating scales which you requested - the Honilton Scale and our own depression rating
scale modified form Lehnann~Rockliff. I have been told that
the Hamilton Scale is the one that the ECDE grasps of NIMH
will probably use. Hmever, we have fomd it convenient to
use our om scale for the time being, but will probably go
to the I-lemilton'Scele in our next study.

I look forward to your visit.
_

Sincerely yours ,
Pink, 14.9.
Professor of Psychiatry

Mex

Wk?

’I‘hegrephsdidnotxeroxmllameillhavetodothen

P.S..
.

over on Wednesday. They will be sent Wednesday afternoon,
but these reports might be useful to get started.
‘

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                    <text>-wvwm

mun—W...»

.

«

ww-

,
m-

rr—vnr‘wn—r.»

..
‘1.

VFW-“WW

August 21, 1967

2r

1-!«rwzrww-r

Dr. William R. Tabor

A.ﬁ.&amp;mhmtbmmmr
1407 Cummings Drive

Richmond, Virginia 23220

Dear

Bill,
Enclosed are the Statement of Investigator Foam

FD

1573,

my

curriculum vitae, and a study protocol for an open study of
fenfluramine in volunteer subjects.‘ Ae-I had indicated to you;
the EEG patterns were so much like barbiturate that the state—
ment that fenfluramine is an anorexigenic agent is surprising;
'

For this reason, I would like to undertake a small Clinical
study in volunteers to see for myself whether these subjects do;
report weight loss and which behaViorel-effects, if any, accompany
such a change.

'

.

,

lhe data indicates that dosages of NO to 80 mg per day seem
appropriate and I will provide each of the subjects with a flexible
dosage schedule.

‘

'

.

As for supplies, I estimate the total study will take 1000
capsules of 20 mg each. However, an initial supply of 300 capsules
of fenfluramine 20 mg and 300 placebo capsules would be enough for

a Start .

Thank you very much

,

'

'

fortyour cooperation.
Sincerely yours,
Max

Fm,

MEL),

Professor of Psychiatry

�</text>
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                    <text>a.“

“I

)ﬁ-wyi'vv »

wﬂwmww'nxmm"rc-l,"f

.ww-nwmvr-v --~-

1»

&lt;

n’ a" WSW-Memzv-‘rgn‘

itm'dhww «autumn-w.

n7-

r.-

».

nu nvwr—en r‘qﬂmr WWIMYumr-derwrw-wr-um-n

rates--

-vmmw-w,_

,

July 20,

1957

Dr. William R. Tabor
Director, Medical Research
A. H. Robins Company
11407 meings Drive
Richmond,

Dear

Virginia

23220

Bill ,

I do not how how successful the presentation was
yesterday, but I enjoyed the opportunity to meet Dr. Rmderburk
and to discuss with him and your associates the present status
of the EEG programs. I was prepared to discuss a specific
project, but that will wait until you can clarify the details.

I

writing to confirm that I an interested in under~
pilot study of fenfluranine as an anorexogenic agent
in a small number of volunteers and would be pleased to receive
the necessary forms and some descriptims of the available
experience so that I can prepare a smitable protocol.
Thank you once again for your visit.
am

1:6de3 a

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>September 28, l967
Dr. William R. Tabor
Director, Medical Research
A. H. Robins Company

l407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill,

Enclosed is a protocol for a study of Repoise - syrup
which has been submitted to the appropriate committees for

expect that this will be obtained within
a month. By that time, I will have had the chance to discuss
the protocol with my full staff and the study may begin in

approval.

early

I would

November.

.

If this protocol is satisfactory,

and as soon as you
have submitted
to the FDA, please call me and we can
discuss the supplies that will be necessary.

it

Thank you

My

for theoopportunity to consider this study.

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>I

{W

.

,u—u

,

-w

Wur-w-rwn-x. ”at ..w
,

-.».m—-p.v. .‘ mm»,

was‘ «(w—www.mw—m‘W—"mvam—

I

E

ﬁovember 20, l967

Sr. ﬁilliam R. Tabor
ﬁ. ﬂ. Robins Company
l407 Cwouings.9rive
Richmond. Virginia 23220
ﬂoor

Eill,

Enclosed is an outline of an experiment to be undertaken
with‘the medical students at the How York medical College. As
part of the class demonstration series in pharmacology. this
demonstration is scheduled for January 9.

I would appreciate your cooperation in making available to
Supplies of fonfluramine and concurrent samples of amobarbital,
dextroamohetamine and placebo as outlined in the attached protocol.

we

'

If this is possible, the oxperiment will provide us with
additional information concerning the sedative or stimulating
Qualities of fenfluramine. I will complete the forms necessary
to consioor this research study. Many thanks.
Sincerely yours,
Max

Fink, $.9.

Professor of Psychiatry

ﬁszp

�</text>
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                    <text>December

l9, l967

Dr. William R. Tabor
Robins Company

A. H.

1407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill,

Thank you for the forms and the protocol for our demonstra~
tion with medical students at the new York Medical College. I

have signed the forms in the appropriate places and believe I
have answered all the open questions.
The

for

pharmacist here will prepare the amobarbital.

Thank you once again
a Happy New Year.

for your cooperation,

and

my

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

,

best wishes

�</text>
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                    <text>w»

.mmmw

warp.

"win!"

January

ll,

1968

Dr. William R. Tabor

A. H.

Robin: 00.. Inc.

1407 Cummings Drive

Richmond, Virginia 23220
Dear

Bill.

Enclosed is a copy of the abstract submitted to the
Society of Biological Psychiatry. Unfortunately. the abstract
was sent too late and the Program Chairman has indicated that
he is unable to include this presentation.

Nevertheless.

can and

will send

I

plan to complete this report as soon as

you a copy.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

�</text>
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-

x

“an.“

”M

-,.-

April 30,

1968

Dr. William Tabor

A. H. Robins Company
1W7 Cmnninge Drive

Mahmud, Virginia

DearBill,
Wehave

meeivedﬂnesupplyofbutapemzineplaceboand
p'Ihestudy

ﬂareportfom. Wyouverymchforboth.

isgoingvery wellmdwearebegirmingﬂxesmmryofour

initial data.

This

will be available in the next

two

Sincerely yours ,
Fink, PM).
Professor of Paydziatry

Max

MF:kp

maths.

�</text>
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                    <text>April 8. 1968
Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive

Richmond. Virginia 23220
Dear

Bill,

I have been reviewing the initial data in the elixir
butaperazine study. I cannot recall
you had indicated
have
a desire to
the
twenty cases reported in a special

if

first

format. Is there a record fonn for these cases that you

would wish us
Many

to use?

thanks.
Sincerely yours,
Fink, M.0.
Proféssor of Psychiatry

Max

MszP

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                    <text>April 1, l968
Dr. William R. Tabor
A. H. Robins Company
1407 Cummings Drive

Richmond. Virginia 23220

Dear

Bill,'

Enclosed is a summary of a demonstration experiment with
fenfluramine (your study 2063) undertaken with second year
medical students at the New York hedical College on January 9
and 10, 1968.

-

The students participating on January 9. volunteered for the
experiment and the data is enclosed. On January lo the students
requested that the experiment not be undertaken since they were
scheduled for examinations beginning January ll. and they had
heard from the first group that some subjects had difficulty
in sleeping. For this reason only 1/4 the number of subjects
actually took the drug.
'

This was my first.experience in a student demonstration
project. For these young men_end women the anxiety of a novel
experiment, in a group setting with much interaction seemed to
so alter their responses that neither amobarbithl nor
dextroamphetamine gave a well defined response. The only
change which may be related to drug effect was the decrease in

digit

symbol score

for amobarbital.

The remaining supplies of fenfluramine are being sent. as
requested to Mr. Collins. The form for Disposition of Investigational

Drugs

is enclosed.

I want to thank you for your cooneration in
which was most enlightening. My best regards.

this study

Sincerely yours,
Pink, ”.9.
Professor of Psychiatry

Max

MF:kp

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v

.,.

v

pruwuamr-n-r

v

,u
a

.m,,..-,-,

any"...

“g.

15,-3.1“...

{-

Juno 26. 1968

numwra

""‘K'K'ma

Dr. William Tabor

A. H. Rabin!
v

.1

(ww-

va-myv-z-mpm-p

an.

.

&amp;

Company

1407 Cunning: Drive
Richmond 20. Virginia

near Bill.

us-wr

«w-

&lt;v

c-

awtm’ﬂ‘c

W7~V~&gt;~o

0
4m;

.I'I'V’ﬁ'ﬂwwynw

In a recent letter you inquired as to our
procedure in adding some tasteful subatance to the
placebo of butaperazina elixir. Adopting a simple
procedure from our community, we have added to the
vehicle a small amount of Angoatura Bitters. This
has added a taste to the medication and, while
distinguishable from butaperaaine on direct trials.
has been of some use in our work.
have summarized each of the cases in the
present population and are now transcribing some of
We

the information to the Robina worksheets. We are
also preparing a written summary of our observations.
As soon as these are available. they will he coat to
you.

My

halt regards.
sincerely yours.
Max

Pink. Md).

Professor of Plyohiatry

Hszp

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                    <text>August

l9, l968

Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive
Richmond 20, Virginia

Dear

Bill.

pleased to enclose our second interim report in our
analysis of the fenfluramine. amobarbital. dextroamphetamine
EEG study.
After an hiatus of many months. we have been able
to get back to this analysis and find that the results, regardless
of which technique of analysis we use, are the same. Fenfluramine
is most distinguishable from amphetamine and least from 50 mg
I am

amobarbital.

are anxious to report this material in the scientific
press and will do so shortly. In the interim, however. you
may feel free to make conies and distribute these within
A. H. Robins or for any governmental submissions which you
may feel necessary.
We

In addition to this report I am enclosing individual case
records of the volunteer subjects in the fenfluramine EEG study.
While in St. Louis on Friday, I discussed the individual case
records of the fenfluramine reaction time subjects with Dr. Itil.
I gave him the forms and he assured me that a member of his staff
would complete them on Monday or Tuesday at the latest and send
them directly to you. Since he felt that he could accomplish the
mission without any assistance from me, I trust this is satisfactory.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc .

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                    <text>October 21, 1963
Dr. William Tabor
Robins Company

A. H.

1407 Cummings Drive
Richmond 20. Virginia

Dear
1
....:-

w

,
-

.

u"

Tag-,1

1;.

.-'MM?,;~"I:_11..

Bill,

Enclosed are a for capies of our interim report of the
studies of Ropoise (butaperazine syrup) in a group of nonresponsive psychotics in a mental health clinic. Previously
we had sent you the case material, laboratory and clinical
data.

Clare and Simeon to revise this for
publication, and look forward to submitting it either to
Cannon: Thehapoutéc.ﬂeoeaach or the Jouanat 05 New Dnugt.
I have asked Drs.

.

my.

man-1w

e

Separately I have sent to Dr. Owen reports of our studies
with Tybatran. I trust he will share these with you. I have
also completed the protocol for AHR~l900 and this will be sent
to Dr. Clark.
Hy

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry
Max

MF:kp

L
L"-

-

two-.-

�</text>
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                    <text>rwr‘u «.-

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Hi wvrur—"‘."Wnrv"vrv

w'

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~:....‘~u-...

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u...»

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g

E

October 10. l968

E

E

s

E

7

E

E

E

é

E

Br. Hilliam Tabor

Robins Company
1407 Cummings Drive

A. H.

Richmond. Virginia
Dear 3111,

We have Just completed this interim report of tybamate.
I have sent copies of the report and case summaries to
Dr. Gwen.

to thank you and the A. H. Robins
in
making this study possible.
cooperation
I want

My

Company

best regards.
Sincerely yours,

E

.

Fink, M.D.
Professor of Psychiatry

Max

“W'KJ‘

W‘Wrn‘m

Intravr'vrj'nw.

xv~._~m.

,

v.

m.

.

w

-r....-.-

mmmﬂ‘wﬂn'wrmww'vav

.-.

Xszp

for your

.v—unw»

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-

..

wr-

—-

.—-

.-.

�</text>
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                    <text>September 21, 1968

Dr. William Thbor

A.H. Robins, Go.
1&amp;0? Cummings Drive

Richmond, Va. 23220

Door 8111,

Separotoly. I have cont you the data collected in tho
liquid vohiclo. You will find the commotion
for each case, the original case data report. laboratory data bound
together, and the NINE data analyses and cord output. Dr. Clot.
and Dr. Simeon have completed a roport of their findings nod this
is now halo; typed. It will bo sent to you for your comments within

Ropoloo study using the

a week.

I

no

particularty interacted in your

comment: ooocorning

the laboratory data output. You know that this rooulto from programs
written here uoing the HIP laboratory scale. Slooo than. on hovo
cooplotod o review of out oxpotionooo and improvod tho data oolloctlon
form 80 that tho drug data will also appear on the final reports.
Copies of those will be coat to you separately. (stunt we hovo
used tho butaperazino material on our working model, I will take
the liberty of sending sample page; from thooo laboratory reports
to the ECDEU lovootigatoto. I truot you hoot no objection.)
Also, I wont to thank you for tho referral of Dr. Clark.
ouggootion that we unaortake a study of the long term offocto
of toofluramino lo a good one nod I will explore this further. I
will send him a protocol on AHR~1900 this nook.

at:

My

boot regards.

sincerely yours.
Max

ml

fink,

N.D.

Professor of Psychiatry

�</text>
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                    <text>September 17, 1968
Dr. William R. Tabor

Robins Company

A. H.

1407 Cummings Drive
Richmond, Virginia 23220

Dear 3111,

I

am

pleased that the fenfluramine material was acceptable.

for being so helpful but it was not necessary
secretary to St. Louis, as Dr. Itil accomplished his
part with his staff. There are no additional expenses.
Thank you

to send

my

Sincerely yours,
Fink, M.D.
th
Professor of Psychiatry
MF:kp

cur-

:vvnvr-

wp

,

�</text>
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                    <text>December- 30, 1968

Dr. William Tabor

A. H. Robins Ounpany
11407 Clmmings Drive

Fidmnnd, Virginia 23220
Dear

Bill,

RE:

Butapemzim. Syrup S’mdy

There are two patients who are receiving butapemzine
syrup and who should continue this form of treatment since
they have done well and Dr. Clare would prefer maintaining

the medication to allow mintenaxwe of the present state .
Smuaries of the two cases are attached.

An investigation of our supplies of 12/ 27 indicates that
we have 9 pints placebo and 70 pints butaperazine available .
Would you please file an mandaent to the study protocol
allow
us to continue these two patients for a minim of
to

one year. As soon as we have found other ways of treating
them we will return the renaining supplies of butaperazine.
Thank you

for your cooperation.
Sincerely yours ,
Max

Fink, Md).

Professor of Psychiatry
MF:kp

�</text>
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                  <elementText elementTextId="105711">
                    <text>December 27, 1968
Dr.

hiiiiam Tabor

1407 Cummings

Richmond, Va. 23220

Biii.

Dear

Enclosed are the corrected butnperazine report forms.
principal difficuity iies in our interpretation of the item 15
and in the inch of discrimination among psychiatric diagnoses.

The

interpreted the item is as

a sampling of the
dosage periods.
occasionniiy
the maintenance dosage; more usually. the maintenance dosage was
somewhat less. The report shows the iargest period of sustained drug
effect. On each, however, we have indicated the maximum dose as
We

had

The maximum dosage achieved was oniy

we

.

Aiso. the date stopped was interpreted as the date of the
report period. In some instances. patients continued
report period. This was occasionaiiy noted on the summary
(narrative) which was written after the summary (report form) was

end of the
beyond the

compieted.

ﬁiagnoses are

all variations of schizophrenia. In some
domponent was given credit in the natretive

instances. the depressive

summary. although chronic schizophrenia was the principai diagnosis.
The use of catatonic, paranoid or simpie subtypes wateadditivo; and

chronic schizophrenia is the principei diagnosis.

trust these corrections cierify the questions.
for bringing these discrepancies to our attention.
I

Thank you

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

of]

�</text>
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                    <text>Decadbmr 10, 1968
Dent 3111,

I plan to be in Miami on Dacembar 12~13. and as I havu to
be in Puerto King on Daccmber 18. that: is a pessibility I will stay
ever. For that reason, I hesitate to make a apacitic date to discuaa
the fenfluraminc extancab study. If I do return on Sund‘y, Dacamber
15. I would like to man: with you on Eanday, attar your athur appointnnnc
or on Tuesday.
ﬂaw York

If I can

Hilton.

maka

it.

I will leava a message far you at the

In the aaauwhile, I will rand tha matarial you sent
and will discuss it with Br. Ittl.
My

best regards.
Sincerely yours.

”3: Fink ’

H. Do

Professor of Paychintry

:2.

William Tabor

A.ﬁ. Robina Co.
Riehmond, Va.

�</text>
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                    <text>November 23, 1968

Dr] William Tabor

A.H. Robin: 00.

Richmond, Virginia

Dan: 3111,

I look forwuré to meeting you on Hooday, December 2.
3
I will be a: a conference on ﬁatropolitan Hospital at 10‘. 00 «.m.
and will be back at my oﬁfioo at 5 East 162 Street by 11:30. Consider~
ing your appointment at 2: 45 can VD meat at noon and try to be through
~

by 2:15 p.m.

?

if that is

at 10:00 a.m.

T

not satisfactory. can

Tho tyhamnte

§

3
E

The

f
g

wo

meet Tunsday morning

protocol for

AHR~1900

'\
\.

Our

wo

can demon~17

have completed our clinical fanfluramine study but have
yet to summarize the data and to complete the cane reoorda.
We

It will be a pleasure to diocusa these projects with you.
Incidentally, both Dr. Simeon and Dr. ﬂashing: were pleased with the
exhibit in Chicago and stimulated us to look forward to another.
Please call

X‘\

has been approved and on1.y requires

laboratory data program is operational and
jatrate the next step as provided Dr. Itil last week.
f

x\

laboratory data and toport are both completodL

your aoquioaconca.

V.

"

my

office to confirm the date.
Sineeroly yours,
Max

Fink,

M. D.

�</text>
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                    <text>April 16. 1969
Dr. William Tabor

A. H. Robins and Compamy
1407 Cummings Road

Richmond. Virginia
Dear

Bill,
I look forward

to having

Would you meet me

floor at 10:00

a.m2

you

visit

on Wednesday. April 30.

at Metropolitan Hospital

on

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

~
-

—

.

war-wuur

u-

W:w)nrp-*F'V.WY‘

the 15th

�</text>
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                    <text>9:20:

,Ei new?

~S-

eta todﬁ .ytncnded

Yntnom txen
‘

10d5T ~13

ni vines tnemtniodqe noedonul woo beaaim on
edt pnitub todteoot pnittog to daemon: ed?

etuov
'

Y

ieweonia

March

i3, i969

Dr. William R. Tabor
Director, Medical Regeprohpygn x3e

A. H. Robi

sh

.

to ﬁoaaat01q

i407 Cummings Drive
Richmond, Virginia 23220

e#:3M

Ogﬁﬁwgﬂkﬁrsneod tauL asd ybute Devi—HHA edt not lsvonoqﬁ .B.q
nice 25 thee ed biuoda betaengua useWetpdt‘emtot edT
ii)as ‘l‘ybamate
paper on Drug Dependence:
haymgymigyed
the galley proof on the tybamate report from the Joannnﬁ 06
Clinical Phaemacotogy and have ordered 300 reprints for our use.
if Mrs. Corneal would like to order an additional supply, please
have her call my secretary.

(2) Buteperazine Syrum Study: This study has appeared in
Canaan: Thenapauxic Reaennch; however, we have not yet received

reprints.
(3)

AHRleDO: With regard to Mr. Banner and the City of
York with regard to AHR-IQOO, i called him and he was
principally interested in a general statement about AHR-lQDO.
After our discussion he indicated that he would approve this
study. He was surprised by the request from the Commissioner
of Hospitals, indicating that this was the first such request
that he had received in twenty years. We have three patients
on the ward now and we are training our staff using butaperazine
(which is apparently quite successful). l anticipate no further
difficulty in obtaining approval and believe it should be forthcoming shortly.
New

Fenfluramine Exhibit for

APA: i regret to tell you that
called the exhibition manager of the APA he indicated that
we were much too late to apply for space, the deadline having
been January l.
am disappointed and accept the responsibility
for not anticipating this deadline. As thought about the kind
of exhibit i wish to make, it occurred to me that we might try
such a display at the forthcoming international EEG meetings in
San Diego (September l4-20, i969). if it is successful there,
perhaps we would like to use that material for the APA in l970.

(4)

when

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March 13, I969

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March

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l2, l969

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mr

Dr. Oidrich Viner
The George Washingfon University

Biomefric Laborafory

ll45 Ninefeenfh Sireef, N.W.,

Room

Washingfon, D.C. 20036

6l8

Dear Dr. Vinar:

Affer

to

yesterday my secrelary reminded me
The defes of the American Psychlefric
Associalion meefings (May 5-9, Miami Beach). These are among fhe
mos? useful meefings of our colleagues.- l fhlnk you would enjoy
affending The meetings and l am sure fhef Dr. Lehmann and ofher
American members of fhe CINP will probably prefer fo effend.
l

spoke

The? May 6 and 7

you

are wifhln

is There still lime To arrange fhe meefing of fhe Program
Commiffee +0 follow The conference on neurolepflcs in Liege?
sure

if necessary,

you

we can forage fhe APA meetings, buf
will agree fhaf affendence at bofh may be more

I

am

profitable.

4"‘v'rvlk

if if is possible for

w

m'r

w

"Winn-I4

you

to visif us,

Roubicek and Dr. Volevka will Join

inferesfing.

me

i

am

sure Professor

in making your

Sincerely yours,

vomA

erw-vmz-zaw

Jun-or

Fink, M.D.
Professor of Psychiatry

Max

Mszp

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1-

7.,

mm,

m—m-w

,-.

... ,.

qmn—~

.15..

r—Iw

«r mm.-- (.wv"
-

May

w

"wru—"'I&gt;‘anv~-:l-—xm

..l~

w, ..

.7

..

v

'«77 Wﬁ—vrver—«yvv1

24, 1969

Dr. William.Tabor

A. H. Robins Company
1407 Cummings

Richmond, Virginia
Dear

Bill,
I

have just returned from a very intereating and useful
to
Euroye to find that our studies have gone ahead. Our
trip
first patient on AER-1900 is now receiving 7.5 mg per day.
Because we are keeping the patients on a placebo period of 2
weoka, I will need an additional 10 x 50 capsules placebo for
ARR 1900. The label is attached.
As you remombor, we have maintained two

patients

on

butaperarine elixir and we would like now to transfer them
to tablets. These are not available in our formulary and
I have taken the first step for their approval. In the
uaantima, would it be possible to make 500, 5 mg tablets
available? If this request is not appropriate for your
office, should I call Mr. Corners or is there another

rapresentative

who you can have

call

on me?

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MP:kp

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                    <text>rOctObsr 31, 1969
Dr.

william“a. Tabor

A. H. Rabins Company
1407 ComMings Brive

Richmond,

Virginia 23220

Dear 8111,

It

Special pleasure to have you, Hunter and Bob
visit Gracie Square last Thursday. I tried to present the
point of View that the efficacy of psychoactive compounds Can
be significantly enhanced if the patients take their modication
regularly, and intake can be improvea if the medication is
presentod in a palatable fashion.
was a

this

ﬁrs. Fritz Freyhan
Friedhoff to discuss training. in psychopharmacology.
Dr. Friedhoff spontaneouslv and independently stated that he
hadﬁgreat difficultywasin toachiM his studentsa at Kew York
insufficient to-givo patient a
University that it
prescription. Tho physician must insure the patients' compliance
with the instructions. ﬁr. Freyhan concurred when I inquired
as to how one insured the patient's intake, they both agreed
parenteral routes were the best and liquid preparations an
important need.
on rueséay of

and Arnold

On

Monday I was

week I met with

told that thlothixene

(Navano)

oral

concentrate had been ayprovod by the FDA at the orofessional
level and that it awaited the final administrative approval,
which was expected within two weeks.
Two

.

150 mg as

oatients are

of today.

find no consistent
Come

visit

on Aha-1900. one at 409 mg and one at
I have reviewed the available HES éata and
changes in dosages ugwto 200 mg/day.

we

again.

My

best regards.

Sincerely yours,

I

Mszp
cc:

Mr. Hunter Spencer

Mr. Robert Nickless

Dr. J at):

med

Fink, .Moi).
Professor of Psychiatry

E‘iax

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October 13, 1969

§
§
E
3

i

Dr. William Tabor
Robins Company

A. H.

:‘w’r

A

1407 Cummings Drive
Ridhmond 20, Virginia

Bill,

Dear

I look forward to seeing you on Thursday, October 23.
I suggest that you came to Gracie Square Hospital (420 East
76th Street), as it is there that I plan to undertake the
studies of butaperazine. I am enclosing a provisional protocol
more thoroughly.
for your review so that we can discuss

it

Incidentally, if you get in early enough on Wednesday,
to have dinner? I will be staying in the City
late that evening and will be pleased to have dinner with you
and your associates.

would you care

I

will ask

Kathy

to call

you on Tuesday.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf;kp

A

a—w-rvmn

.[f'r—vv-mmv

�</text>
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                    <text>September 29k 1969
Dr. William Tabor
A. H. Robins
1H0? Cummings

Richmond,
Dear

Virginia

Bill,

like to revise the protocol for the
study. We have failed to see behavioral
EEG
effects at the dosages up to 200 mg/day for
or
10-1h-days. For the next few subjects we will increase
We

ARR-1900

would

the daily dosages to ROD mg a day.
In order to accomplish this, may we have an
additional supply of AHR~1900, 30 x 50 x 10 mg?
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF : kp

�</text>
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                    <text>J
.
_
.

_

H

A,“

1..“

"nu—WWW

”M

,.

,
A'oww

Warm...”

September

l0, l969

Dr. Hilliam Tabor
A. H. Robins Company

l407 Cummings Drive
Richmond 20, Virginia
RE:

Dear 3111,

Please
follows.

amend our

AHR-l900

protocol for the study of

will be increased to 200 mg daily,
maintained for periods up to four weeks.
Dosage

AHR-lQOO

as

and will be

rate of administration of medication will be daily
increments of lo mg for three days. 20 mg for three days
and 40 mg a day thereafter (a possible schedule is l0 ~ 20 200).
lOO - l40 - l80
30 - 40 ~ 60 - 80
The

—

—

he have observed no changes in blood pressure which
would make us hesitate on such a rapid increase.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>November

7,

1969

Dr. William Tabor
Robins Company

A. H.

1407 Cummings Drive
Richmond 20, Virginia

Bear 8111.
To correct an oversight, I have requested approval by
the Formulary Committee of Metropolitan Hospital for a 1 year
trial of butaperazine (Repoise) tablets. If agreeable to you,
would you either ask your reprosontative to make supplies
available to the pharmacist, Mrs. Crusade or deliver a supply
to my offico. I could suggest 1000 tablets each of 10 and
25 mg

to start.

Whoa

;

approved, I will ask Dr. Simeon to make our

reports available to the staff.

Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

Mszp

�</text>
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                    <text>l 3 1 1 11

.w-

~11

,

-n‘:'~'r-v

“r

uj'v

.

"7mm ~—..w.w—-—..—

VFW

,

v—"r-I—I—u

wwmmrF-m-V

n

mjw—W-._.m._v.wﬁ7-..."

----_....-mw-.ww.-w_1

V

m,7.....-A-..A-‘._._...._v--,-_

“Hwy",w,“

March

l7, I970

Dr. Wllilam Tabor
A. H. Robins Company
I407 Cummings Drive

Richmond 20,

Dear

Virginia

Bill,
if seems rldlcuious fo val? for fhe ﬁlamefric

revtew of

Laborafory

Separafoly, I am sending you Two books
confalnlnq fho date of AHR-IQOO - your sfudy voiume which
Includes our summaries, data sheafs and +ho dafa evaluation,
and our laborafory dafa output.
AHR-IQOO.

As

soon as The Biomefrlc Laborafory lnformaflon ls
I will
ship I? #0 you and wrifo a publicaflon

My

has? regards.

available.
report.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychtafry
Mszp

�</text>
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                    <text>March

l0, l970

Dr. William Tabor

A. H. Robins Company
i407 Cummings Drivo

Richmond, Virginia
Dear

Bill,

A review of our AHR~|900 laborafory data for changes in
blood glucose suggesfs fhal a hypoglycemic effect may occur
in some subjects, but our data is unimprossive. An absfracl
of fhis dafa is enclosed.

Blood glucose (88) measures during AHR~i900 and placebo

periods are available for

6

subjecis recaivlng

AHR~l900 in

400 mg. in L.F., J.M., A.G., and J.V., blood
dosages
in one measure each than during lho placebo
lower
glucose is
and
D.K.
in
period;
0.5., blood glucose remains of the some
in
blood
level.
L.E..
glucose is low bu? no preudrug oonlroi
AHR*l900 for 9 days only and The
received
is available. J.L.
no?
88
is
value
consfrucfive. Subjocf M.D. did not
single
have leafs while on N4R—l900 and R.L. and E.H. received placebo
only. When i asked Dr. Jones, our lnlernisl, she reiafed The
low 86 readings in 3 of The palienis lo dosages of l20 mg or
more of AHR-IQOO.
up To

available for shipmenl, as
ind
for
final
is our roporl, excopl
analyses from The Siomofric
To
do
awai?
these
complale fhe publicalion reporl.
Loborafory.
The ofher data on NlR~i9OO is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mkap
911C

.

�</text>
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                    <text>run-“=-“WV“:"F‘F‘I'T

v "-‘wxw «wry-“rpm

,

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Mar” :0, mm
Br. Wiiiiaa Tabor
A. H. Rabin: Company

,

;

14$? Cummings Reaﬁ

;

Richmond, Virginia

Saar

ﬁiii.

hava camgiaiad fhE data anaiy$as en #ha Misseuri
fanfiuramine raacfion time data. Eariiar ya had raviaved fha
function fime inf¢rmefion and we hava new comaia+ad fha behavicrai
ﬂan and

i

and £EG dafa. Summari¢s are aaciosad, markad “interim ﬂapcrts”
Marah iQ and Aprii 8. The nriginai data analysas are in car

iabarafory.

puzzling compaﬂanf. ﬁubjacfs in groug i haw»
a significanf érug aifec? (thav received pincsbw for *hrsa Igeks
bafora arug) whiie suhjects in group ii hava a weak attact. ya
axamined fhe daia for dasaga by weighf and faund ii++ia variatiaa
in dase ~ (caicuiafmd as pcunds/capsuia, i t 4?. 75 t 8.ﬂ3 and
we mate one

E

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i

ii

i

67. 90 ‘ ﬂ. 2i)

reacfien #ime E55 and behaviorai dafa ara all in fha
sama direcfian and unpaar ennsisfanf wifh the interpretufion thn?
feafiuramina was acting as a saaaiiva drug. Whiia muifivariafe
stafisfics can ba dong; ya ara n9? sufficienfiy comfortabio wifh
fha behaviorai data in baiiava that fha resuits are worfh fha
The

axpansm.

Affar raviauing fhis aaia. weuid

you

pinasa caii ua.

Sinceraiy years,
~

nr-yrv-vmv.

Max
Tamar-

2

Fink, H.9.'

Prefessor 9f Psychiatry

an-vww'w:

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gr. P. Preston

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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

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                    <text>w-

I'd-“Yi'ﬂ’v‘

CW?

....

_

v.9

'Im'wu'v

'r|:\&lt;':‘-V'

«unww—MWY—

«yum ‘7’
.

_

Y,

._.,..,

_~-.

..

.IV-‘yﬁv"-n

new

«Vaultsv‘

.

..

September 10, 1970

v“

VIP-"Wm“

....-.-..wr. Fm

Dr. William Tabor
Robins

A. H.

1407 Cummings

Richmond,

Virginia

23225

n—rv

y-u-uwv‘uw',

mw-w

Bill,

Dear

I have read the protocol of AHR 3000—E (butaperazine) dated
6/10/70 with interest, and believe we can participate in the
assessment both of the bioavailability and therapeutic equivalence
of BPz tablets and concentrate. I find one serious problem with the

design.

'"W'JWII.

:-

.wvwns-w—wwarw-m-v

'v"

“wavy.-

'1
‘

$1:me

for

it, each subject is to receive tablets SP:
transfer directly to concentrate BPz, at the
dosage as tablets BPz. The assumption is that the equivalence
As I

WV'VX‘I'I'Fﬁ'AHWW'm

6

same

understand

weeks and then

of the

two formulations will be assessed by the continued improve~
nent of the patients.

Such a conclusion is valid only if psychotic patients deprived
of active antipsychotic medication would uniformly relapse on drug

withdrawal. But such is not the case, and on cessation of antipsychotic medication a number of patients may maintain improvement
for many weeks after withdaawal (see Gottschalk gt_gl;, Comp. Psychiat..
11: 123-140 (spec. pg. 135]; Kamano, Psychol. Rep., 19: 743-749. 1966;
Gittelman et a1., Psychopharmacology A Review of Progress. 1119-1154,
1969). Thasy“f? patients treated for 6 weeks are given placebo, not
all will relapse within the next 6 weeks.

this reason,

that the patients randomly
concentrate 8?: first; and for those who
stabilize in 6 weeks, transfer to the other formulation for a
second 6 weeks - avoiding the objection raised in my mind.
For

receive tablets
““mr.1i1-v

My
-

BF: and

I would suggest

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

up-

u.

“4..

..w--

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                    <text>September 5, 1970
Dr. William Tabor
A. H. Robins Co.
1407 Cummings

Richmond,

Virginia

Dear 3111,

In Istanbul, I first heard the summary data of the studies on
butaperszine in Istanbul, Furnington and St. Louis, including a most
interesting comparison of the data with that of Denber - Bente. All
Keskiner presented the data well, and I am writing to suggest that
you will find the report of special interest. I am sure he or Tursn

Itil

will
My

make

it

available.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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.m

any.”

w"

mm

January 2!, 1971

m

“VJ-r...

UFWWSF’WWHWW

Dr. William Tabor

A. H. Robina Company
1407 Cummings Drive

Virginia

Richmond,

Dear

Bill.

have received the ARR-1118 date and find that single
doses of 200 mg seem adequate to produce an EEG change. To
verify this, however, I would like to run a few single trials
at higher doeeges, Specifically 250, 300 end 400 mg. I would
like to run two to four experiments at each done.
We

Our

data to date

show 200 mg

well tolerated by volunteers.

(:6 3.4

mg/kg) are

safe

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mr:kt

and

�</text>
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                    <text>January 14, 1971
Dr. William Tabor

A. H. Robins Co.

Richmond, Virginia
Dear

Bill,

vitae,

I

am

enclosing the statement of investigator form, curriculum

and a signed copy of the protocol for the hutaperazine
concentrate study. I believe we can fulfil the study goals with
the following amendments:
We

are not acquainted with the

this form, if necssary, but

would
changes in the EPRS and the C61.
The

protocol suggests

try to use
prefer to define the drug related
ROSIE. We can

all patients reclitethhe tablets first

and the concentrate on an immediate crossover. We should have a
comparison group and will elect to start some patients on the concentrate
with a crossover to the tablets.
15

I estimate an average dose of 50

patients,

we

will require

and an equal amount (6

butaperazine daily. For
butaperazine in tablet form
of the concentrate.

40 grams

liters)

mg

can begin some patients as soon as the supplies are
available, and will complete the study etethe optimal center
We

made

available this spring.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>May
BIL.

19, 1971

Tuba/L
Wan
Robins Co.

A. H.

1407 Cwmuingb Waive

ﬁd’lmond, Vugiwéa
‘Detm BLUE,

I am bending nude/L éepmate. cave/r. the 541m! nape/ct on
Pawns 05 Fenﬂmmlne, Ambwm and Damnanphuwnine
Thu bzwnpomtu copied, a all the
Mom
Aim/tied plwcedwcu which we wed in anatyzing me gengwmmlne
data. I Auggut that you keep tlu'A capg a5 a max/ta 05 you):
deco/nib and me the aux/mated MPOJ‘l/t Aubmltted but weak.

"EEG
12:

Vchm”.

I want

paueme

a

to thank

ﬂux

you once again 604 you); coopemxx’on and
Atudy.

3&amp;ch

goww ,

maﬁa/54M 05
Alf-312x

Paychéaw

�</text>
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                    <text>May

17, 1971

Dr. William Tabor
Robina Co.
1407 Cummings Drive
Richmond, Virginia

A. H.

Dear

Bill,

"EEG

I am pleased to enclose a draft copy of our final report,
Profiles of Fenfluramine, Anabarbital and Dextroamphetanina

in

Normal Volunteers”, as submitted to Payohopharmacologia.

Separately, I am sending you a complete report which contains
additional data analyses. we found some redundant and abstracted
our experience for the report for publication. You may elect to
use either report for your files and references.
Many

thanks for your

interest:

and

my

best regards.

Sincerely yours,
Fink, N.D.
Professor of Psychiatry

Mar

Mszt

�</text>
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                    <text>May

13. 1971

Dr. William Tabor
A. H. Robins

1407 Cummings Road
Richmond, Virginia

Door 8111,

have recently completed our pilot EEG study of AHR~1118.
including experiments with single doses up to 350 ng, equivalent
to 4.5 ~ 5.0 ng/kg. We have summarised this data and I am enclosing
a capy for your information and files.
We

we have had difficulty in eliciting a
At these higher dosages, however, sous
changes are prominent and to confirm these, I have undertaken a
direct comparison, on a random assignment double~blind basis of
single doses of ARR 1118 vs. placebo. The dosage selected is
based on body weight, so that we will average 4.0 — 4.3 mg/kg.
The variation is based on the 50 mg size capsule available.

In these experiments,

consistent

EEG

pattern.

This study will be completed in early June at present rate
of examinations.

It

was good to see you

in Atlantic City.
Sincerely yours,
ﬂax Pink, H.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>v.

zen—m.»

*x-n’V‘

-—~xv.g-g.v.r~«,

.—

—.

9"».

A
-

October 22, 1971

w.

Dr. William Tabor

army-warr—v-r-wp-

A. B. Robins Co.

Richmond, Virginia
Deer

Bill,
I have asked

my

assistants to transcribe the data
is some

1118 experiments on the forms provided. There
ambiguity as to whether a form should be provided for each
from the

AER

experiment, or for the variety of experilants for each subject.
I have enclosed a xerox copy of one record for your review. If this
is satisfactory, the data sheets will be prepared for shipment.
If you prefer another format, please advise.

for your kind hospitality and
understanding during my recent visit. Also, I very much appreciate
the description of the use of doxeprem in heroin overdose. It will
be made available in my clinic and we will test its use for our
Thank you very much

problems.

My

best regards.

'

ren—

Sincerely yours,

.

‘im'VIJ'T‘V‘qu‘U

Aux

Mex

Fink, M.D.

Professor of Psychiatry

v.

-r:'u

mauww

\

�</text>
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                    <text>Hovember 5, 1971

William Tabor, 24.0.
A. E. Robins 00.
Richmond, Virginia

Dear

Bill,

for the

Enclosed are the completed
study, your number 1301.

AER-4118

It

was

My

best regards.

clinical data form

a pleasure to have the opportunity to

review this compound. Hazy thanks.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>March 22, 1978

William R. Tabor, M.D.
A. H. Robins Co.

Richmond, Virginia 23220
Dear

Bill,

I was saddened by your note of March 13 indicating that
further study of lenperone was suspended. Having followed the
progress of the development of this drug from its early clinical
trials, I know how much effort (and dollars) have been expended.
I do not know where lenperone would have fallen in the therapeutic
spectrum, but we are all losers ~- patients and physicians alike -in losing the opportunity to test the compound in the clinical
marketplace, where so many of the applications have been discovered.
I

do hope

that

you have a replacement on the way.

no longer have any supplies on hand, and will
follow your admonition regarding our records.
we

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>WEE

‘

mum—w

March 1, 1972

Dr. Arthur W. Increiter
March Sharp 6 Donna Rascarch LaboratorieWest Point, Pennsylvania 19486
Dear Dr.

Iacroltcr:

The supply of levomethadyl arrived safely w many thanks.
augment our studies by incraaaing the
nunbcr of subjects and the time. Our report is now in galley
for the JANA, and should Appear shortly.

We

will use this supply to
My

best regards.
Sincerely yours,
2h! Fink, Moi):
Professor of Psychiatry

mrzig

cc; Clyda Strickland, 3.0.

�</text>
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                    <text>-Ww

February 8, 1972

Dr. Arthur W. Tacroitor,
Merck Sharp £- Donna

3.0.

Division of Harck &amp; Colpany, Inc;
Heat Point, Pcnnnylvania 19686
Dear Dr.

Tacroitor:

for making additional ouppliao of tralpha-acetylmethadol available for our studies. I an ancloaing the appropriate
3ND 222C form and a xerox of the schedule I permit PF0024555.
Thank you

I trust our ongoing studies will continue to support the
usefullssa of this compound.
Sincerely yours,
ﬂax Fink, M.D.
Professor of Psychiatry

ﬁF:ig
Enc.

.

�</text>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Correspondence</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Correspondence to: Tacreiter, Arthur W.</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Text</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="51916">
                <text>mfp-05-00-026-1-080</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="51917">
                <text>1972 </text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="51918">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
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          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="51920">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="51921">
                <text/>
              </elementText>
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          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="51922">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="51923">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
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          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="79394">
                <text>en-US</text>
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          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="85955">
                <text>application/pdf</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="92516">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="99077">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
