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                    <text>«mm-m-mw——“ an
--

April 27,

.u'wrw.~!wﬁ‘nan—rawmm-u-vw.um ..

1970

Dr. Albert Silverman
Rutgers Hedical School
New Brunswick, New Jersey
Dear Al,

I look forward to participating in the APA Divisional
meeting in Newark in November. The program participants are all friends
and I am sure we will have an interesting experience.
the focus would be convulsive therapy.
program should focus on this, and the title
"Neurophysiological Aspects of Treatment" might be focussed in the
title, ”Neurophysiological Aspects of Convulsive Therapies”. If the
program is more general, and related to drug therapies as well, then
the title should be more descriptive, like " Neurophysiological Aspects
of Somatic Therapies".($omatic may be replaced by organic or biological).
Noch mentioned

If that is so, then the

My

best regards,

and

my

thanks for the

invitation.

Sincerely yours,
Max

Fink, ¥.D.

Professor of Psychiatry

mf/

“WV—warn.mw—v. -&lt;

�</text>
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                    <text>catcher

18 , 1963

Albert J. Silvexm. H. D.
Depertmnt of Peymietxy
Nee adversity Meal Center
North Carolina

mm,

Dear-A1,
Mr. Ben Wiper

kind regards. may

of

than.

881.

visited

me

yesterday and extmded your

Iwmldlihetotmthiecwcmmitytocmmmhteyw
spring

memo! theyeer. notablythe
andfell,whenthehillschewJemymettmirmtbemifulm
ﬂvingbecomemetplemt. Immywhevelnwdmmyetoﬂee
abmttluprobleuotNewJemy,butfwmmofwfmlymdfcr
wlfithaeelweyebeenewetwmderfulpertofthemm.
I have just minted ny tint year of organizing this research
center. It has been 4: diffth but very exciting tin, and in some ways
I
the

ymneweppcintunt. 113mm

envy you

13!

15‘:ng

Why.

very best

Mm.
Sincerely

yam,

We
m
Dimctw

Me Do

�</text>
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                    <text>1‘11”»vﬁnv umfmwr'mv W

V,

”'1"

V

’

‘

..

,

‘

v

.

,

'

'

..

’12:.

;

_

.

.Vv—r—I-wrwg

4‘-..

.

,,r..

~—

.V—

v

..
in.

vrnv-

"Narracw—v.

‘ILﬂa

.1,

n-vvr-

_

_.Qgteber 20, 1967

:

y
7

‘

,

i

Dr. Albert J, Siiyeimah
Chairman, Senartment ofyPéychiatry‘l
The State UniverSity
.Rutgers
—

New'Brunswick, ﬂew Jersey
'

Bear Br. Siiverman;

behalf off9r§ Nafi7Kiremitci whom I have
recommenéed to Dr. Nennc_for the position 9f“Directer of Research
"
I?
at the Marlboro State HQSPitai.
I am-writing On

'

'

'

~

.

of Dr. Kirawitci’sawerk in.1960*61 when he was in
new York. After that he returned to Turkey te compiete his
military service and on one of mygvisits'te IStanbui I met him‘
and recommended his appointmant tb,tne MisSouri Institute'of
Psychiatry at the University of Eissouri School of‘ﬁedicin91
'He jéined the Institute in‘iQESfanﬂ has been an active particigant.
in the psychopharmacoiogicai:researCh programs. These studies.
were under the-direct supervision of Dr. Turan M. Iti].
I knew

‘

‘

The

principal studies with_which

he

haéibeeniiéentified

xhe
are those of phencyciidiqe,in chronic schizophrenics andintravenous
geffects can G and behaviar in voiﬂnteérs 6f the acute
'administratian of experimental psychoactive compounds., Iﬁ-these
studies his principal respansibiiity has aeen ciinicai supervision
and behavioral observations.f
,i
'

'

abiiity ta Carry through a project
of reportsthich'are now in press. He

Br. Kiremitci has shawn an

and has

written

a number

ability as a psychcpathpiogist and has demonstrated
interest in the usg cf rating‘scaies;

has

»

optimistic that

he

a special
V

.

is

capablé to carry out independent
in'
clinical research.projects.; Insofar as he is interested
him
recommend
estabiishing hisiown-study pragram; I am pleased to
for tha position described hy arxjﬁenno.*
I am

‘

,

My

best regards.
Sincereiy yaurs,

mum-swarmwumwz-wznwmmvw—Wrgmaw

‘

mezkp'

ﬂax Fink, M.0.

Prpfessor of Psychiatry

*

r,

,

r

mamrmnm~wzyrnﬂy

,‘

�</text>
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                    <text>9r. A‘bert,J. SilverMan

'

November 8, 1967

Professor and Chairman
Rutgers a The State University
New Brunswick. New Jersey 08903
.

‘Dear A],

NhtIe I have knawn Dr. Kiramftci for some years, our
association has been axclusively 1n the Inboratcry. We had
no medical students in St. Louis; and the residency training

,,

«WV

.
‘

was

_,

a

‘

‘

principalTy by individual lectures.

..

'

‘
_.

¢

Sincereiy yours,

‘.

4

w”-

r
h

Max

Any-q.“

—-

-H’L*;r‘

"mm-“n

I
~

..

any.»

“1.40%",

v

‘
A

,.
v

v-.,:ur.mv,»

n'nfl-lrr'.arr-"‘1—'wn&lt;

1$rwm._..rw.rmw;rv

:1"

r4

au-

arm,

«v.

V:

Fink,

M.D.

Prafessar 0f Psychiatry

«.

Mszp

�</text>
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                    <text>February 9, 1971
Dr. Albert
.—.-.~

,.

ramp

J. Silverman

Professor and Chairman
University Hospital
Neuropsychiatric Institute

Ann Arbor, Michigan 48104

nag-«n

‘v'vn

Dear A1,

l‘ww

I have discussed your letter to Arnie Friedhoff regarding
in the APPA with other members of the Council. The
Assotiation has faced this problem before, and has established
a category of membership; "corresponding member" for this
contingency. Corresponding members are privileged to receive
all communications, attend meetings, participate in committee
functions.

-.

membership

We would be pleased to include you in the membership.
to active status can be made at your request.

Will you reconsider?
«4,

My
awry—mummy”

best regards.
Sincerely yours,

pry,-

.

V

Fink,
Secretary

Max
WNW».

«NW

3!
734'!-

"W"

urJ-‘u-vm—Jr'v

Twmfm.rj-E‘an1-rj.wr

’5».

~

MF:kt

M.D.

Transfer

�</text>
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                    <text>c

“7",,

vur

7...,—

August 3. 1978

Albert J. Silverman, M.D.
Professor 5 Chairman
Department of Psychiatry
University of Michigan
Ann Arbor, Michigan

Deer Al,

It is

easy to write a letter about Oliver Nikolovski.
New York Medical College in 1968
wozked with me for a year at
or 19 9.
He is a well trained European psychiatrist withlsdediceted
enthusiasm for research. He is reliable and carries out protocols to

He

the letter. He is likeable and friendly. He is also obsequious, sometimes
I think to a fault, and obsessive to a degree that made it difficult
for me to work with him. I recommended he work in the clinic at
NYMC and he did a commendable Job until he became restive for advancement.
When Al Freedman did not promote Oliver, he sought fbr a progessorship
elsewhere, and found it in North Dakota. I suggested that he was paying
a high price for a title which would come in time, but he went anyway,
and is now seeking other employment (he froze in ND last winter).

If

you have a

If

you are seeking a

My

best regards.

clinical position in which you seek a reliable,
methodical, careful, unimaginative worker-- Oliver is your man.
researcher, seek elsewhere.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>DEPARTMENT OF EXPERIMENTAL PSYCHIATRY

May

8, 1962

Dr. Daniel Silverman

19th St.
Philadelphia 3, Pa.
269 South

Dear Dan:

I would have been pleased to serve on the Eastern
Audit Committee this year, but as my plans are rapidly
changing, it is unlikely that I will be in New York on an
extended basis by that time, and could not meet with the
other members conveniently. I should be glad to serve the
Society in another capacity, however, if you wish.

EEG

Sincerely yours,
Hthp

Mex

Fink,

M.D.

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Max

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                    <text>March 23 , 1967

Dr. Daniel Silvennan
269 South 19th Street

Philadelphia 3, Pennsylvania
Dear Dan,

Surely, the problan

is of sufficient general interest

to warrant repetition. I can

do my best to present the
material as presented in Denver. If the other participants
would be willing to give you a projected date for the
manuscripts, I will tell you what my own schedule is and
do my best to met a comm date.
My

best wishes.
Sincemly yours ,
Fink, M.D.
Professor of Peychiatzy

Max
MI-‘:kp

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                    <text>February

9,

1967

Dr. Daniel Silverman
269 South 19th Street
Philadelphia 3 , Pennsylvania
Dear Dan,

It was good of you to write about the reception of the
symposiwn in Denver. I have been puzzled by the many questions
that seemed angtmzentative and I left the meetings feeling that
sanewhat more heat than light had been generated.
the

With regard to publishing a smmary ‘of EEG and drug effects,
American College of Neumpsychophamxaoology has planned a

of the changes in this field during the past
the subjects to be covered are the newcphysiological
effects and I am already admitted to writing an expanded review
of the material presented in Denver for presentation in December
and publication in 1968.
Perhaps this volmxe will serve the
need ym suggested.
review of

decade.

'

many

Among

Sincerely yours ,
Max

Pink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>,,,. aamr-mzwwmw-u-nwvwwmm-smrut

w:‘..,-.v;,-ymvrhwﬂcNa-g._-,“

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"Irv-p: .
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-

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-—-.

2l, l967

Dr. Daniel Silverman
269 South l9th Street

Philadelphia 3, Pennsylvania
Dear Dan,
I

have not forgotten the paper

for the

monograph of

EEG

to

effects. In response to a request by the
review the literature regarding EEG and drug effect for a
forthcoming symposium in Puerto Rico, I have devoted much
time to a detailed review of the extensive experiences in

and drug

AChP

the literature. The draft of the material presented at thew
EEG Society is unsatisfactory and I have delayeo sending it
to you pending some critique and review by my associates.
This has. and will delay my manuscript for a few more weeks.

._.

«._.1....,.¢,..I_.,_.,;,[

m'.‘h.(

v.7,

have read the minutes of the meeting and have made my
notes. From your letter. I assume weeare not bound by the
exact responses made at the meeting and I am taking the
I

liberty of responding to the questions to the best of
present ability.
I know how

only hope that

will write to

a delay means, but I can
be justified by a better product. I

exasperating such

it will

you

shortly.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

‘Max

MF:kp

my

7,.

mums-q].

_

”avg. .,.

,.

,

.,.,..-_ .1.

,9,

�</text>
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                    <text>January 25, l968
Dr. Daniel Silverman
269 South l9th Street

Philadelphia 3, Pennsylvania
Dear Dan,

in no position to advise you on how to act with
delinquents. Perhaps reconstructing the remarks of recalcitrant
discussants or omitting their remarks all together are the
I am

principal solutions.

delighted if the; were to appear as a supplement
Journal. I have no objections to editorial assistance

I would be

to the

EEG

from Hoffman-LaRoche.
Good luck!

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

‘

WWII.”

�</text>
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                    <text>January 10, 1963
Dr. Daniel Siiverman
269 South 19th Street

Philadeiphia 3. Pennsylvania

Dear Dan,

Enclosed

American

EEG

discussion.

is a final copy of the presentation at the
Society. as well as modifications of the
I

trust this is satisfactory.

for your patience.

Many

thanks

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Mex

NF:kp

�</text>
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                    <text>September 12, 1978

Gerald Sarwer—Foner, M.D.

Professor

&amp;

Chairman

Department of Psychiatry

University of Ottawa
Ottawa, Canada
Dear Gerry,

Enclosed is a draft copy of the report "A History of
Convulsive Therapy" which relates the history of the past forty
years. I felt that to limit the description to a shorter period

did not do Justice to the

men who embarked on

this treatment,

nor did it give a flavor of the continuing process of evaluation
and development that has marked this remarkable treatment of the

mentally

ill.

I hope that you find this acceptable for publication.
I look forward to your critique.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>-

‘
um

.n

.Y,

-

'iawm'Iw-YrTJWYV‘uvI

73SB~799SB
30 November 1973
M

E M O R A N D U H

To:

Sherman N.

Prom:

Hex

Fink,

Kieffer,

M.D.

M.D.

Subject: Grant Pr0p0881-Pagal

3B~C-D

conceived of the central office staff and the University
as "supporting perooonel." As the overall director, we
envisaged you needing two coordinators. The associate profes—
We

staff

sor/director (helf~tine) ie responsible for the clinical aspects
of the progrema in the CBC, particularly in providing aedioal

psyehiatrio coverage for the eaten in the program. The
laboratory director ie responsible for oaintaining the best
standards for laboratory prooeseee. particularly biochemistry
and physiological support services.
and

The ooordinator (a.u. or M.3.w.) is responsible for input
of patient: to the programs, trenefer of patients to other
facilities. and assurance that the prayer permits. laboratory
teats. and rehebilitetivo services are obtained for each patient.
The

bioatatiatioien works with the coordinator

administrative assistant provieee for the collection

tietioal processing

and the
and ate—

of all of the data forms necessary for
the reports requested by the oootrector. He may also assist
the scientists in evaluation of their data.

administrative anaiatent and secretary are seen ea
responsible for the expenditure of funds, payroll, purchase of
supplies. equipment, etc,, as wall as serving the reporting
requirements tor the variant parts of this program.
The

research associate, two researoh assistants, and the
eleetﬁloic technician were included as scientific personnel
to assist the investigators in carrying out some of the atmiieo
The

-1-

�Kieffer,

S. N.

M.D.

listed in the proposal.

~2~

30

Hovenber 1973

recognized that 3+ positions are
merely token personnel, but this was the remainder of the money
left from the figure of $500,000. It represents a research
assistant and electronic technician for the EEG programs; a
research assistant for Dr. Taylor or Dr. Miller; and a research
assistant level to work with Dre. Taylor, Miller. or Der-men.
(We recognise the fact that the funds assigned to Equipment
and not expended in that category can be transferred to Personnel and did so in the plans for the second and third years
of the project.)

gguinuent Requests:

was seen as

we

The equipment

50: the research ward

additional materiel for the 8 beds of the research
office equipment of desks. typewriters, and cel-

unit. The
culators were envisaged as being used by the personnel
word as well as the supporting personnel.

is justified

by the fact that we envisaged par—
senior scientists and that their reports would ordinarily inundete the few secretarial positions
unless we provided the means whereby the reports could easily
be edited. We elected purchase rather than rental, following
the present governmental guidelines that purchase is preferred
where rental costs will exceed purchase for the life of the
project.
The MIIST

ticipation

‘

on the

by 12 or mo;c

Laboratory Equipment consists of two groups of items:
equipment for neurophysiology and peychophysiology. and a
contribution for the genetic studies. In making up this list,
we recognized the fact that Dre. Lodge, Tursky,‘Msrlis. Turner,
and Fink already had equipment to carry out some of their work
and that additional equipment night he provided from the nogotiated requests with New York State for a research center
or other grants to be submitted when the CRC is established.

Alteration and Renovation: After examining the plane
for the research building, we are requesting funds to modify
the facilities for specific research aspects of this proposal,
particularly for psychophysiology, biocthistry, genetics. and
direct patient observation.

It might be helpful to indicate_thet this operationnie
designed to carry out studies in addition to those already
ongoing. The ongoing studies eto:se the V.A. and no funds
are requested for personnel or renovation for the total pro~
gram of evaluation of narcotic antagonists. In the equipmelt
categories, one of the psychophysiology laboratories probably
would he set up at Northport for the narcotic antagonist work;
and the second at the CRC for the many studies of the second
N.B.

section.

HF/cis

�</text>
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                    <text>7483-02483
18 January 1976

Frank

M.

Berger,

M.D.

680 Madison Avenue
New York, New York 10021
Dear Frank:

I am pleased to send you a copy of the report on cyclazo~
cine as an antidepreaaaat and a few other reprints related to
the EEG profile mothod--a method which permits us to anticipate
the clinical application of putativo psychoactive drugs.
I understand that you have left the formal, quiet halls of
industry to enter the more bustling fields of consulting.
My

best regards,
Sincerely yours.
Fink, M.D.
Profaeaor of Psychiatry

Max

MF/cia

Encls.

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                    <text>May

16, 197h

Miss Mary Carol Revmann
SAODAP

Place, N.W.
washington, 9.0. 20506
726 Jackson

Dear Miss Newmann:
we

would be pleased

to cooPerate in the analysis of the

records to he collected in the SAODAP LdAM~methadone compari—
son study. As I understand the problem, the principal question is
to define the efficacy and the safety of s new pleparetion, levemethsdyl, in comparison with the standard treatment, methadone.
The EEG data is suggested as an index of safety, to define the
degree of changes in EEG as a measure of brain function during
EEG

treatment.

In our studies of methadone and levomethsdyl, we observed
systematic changes in the EEG with both compounds. The changes

related to the dose of each compound, the time after adminis~
tration, and to the time intthe induction (build-us; to the opioid.
Our studies with methadone defined persistent changes during the

'vere

h—6 weeks with episodes of EEG slowing and
which
burst activity
disappeared once a maintenance-dose was
stabilized and the patient received his dosage regularly. Dosage
regularity was important, for in a few instances we Observed theta
,‘burst activity in patients on maintenance therapy (100 mg methadone)
than drug intake was irregular or some additional substances were

build~up period of

used, usually opiates.

‘

it

For this reason,
could be important that the observatwo
tions be comparable in the
groups, particularly as to the
_regularity with which the dosages are given and the number of hours
siter a dose the EEG is recorded. As is usual with Quantitative
EEG analysis, the state of alertness of the sdee
must be con»
trolled; we do so by recording each sthect at the some time of

t

�Mhry Carol Hewmann

~2-

May

16, 197h

day, with the recording made with eyes closed for h minute 20
seconds out of every five minute sample - that is, the subjects
open their eyes and answer a simple inquiry every five minutes.
we believe a 20 minute sample to be an adequate estimate
of an EEG for our purposes. The sample should be in five minute
blocs with a to second eye opening in between. The details of the
recording for our analyses are described in the enclosed memorandum.

The

initial

data reduction

may be

either by period anal~

ysis or by power spectral density analysis. We have found both
useful for drug classification work. Unless your consultants request otherwise, I would recommend period analysis primary wave and
first derivative, using 20 second epochs, and 320 sps sampling rate.
We would analyse one load pair, preferably occipital~vertex first;
and only do a second if there are questions that are left unanswered
by the first analysis. We suggest that the recording on magnetic
tape be of the occipital-vertex, anterior temporal-occipital, and
frontalwoccipital electrode leads on one side. Should there be a
question of differences in symmetry, then a pair of symmetric leads
may be

recorded and analysed.

If the

records are presented cleanly on the tape, we can
l/h real time for period analysis or real time
for power spectral density analysis.

process the data at

fer each record by period analderive standard scores by contrasting the drug
periods with the pro-drug record. If a pro—drug record is not
available, then we can contrast the drug changes with the initial
record in each'subject, should you define the first records as
equivalent for subJects beiteen groups.
Having reduced the data

ysis (or

PWRS), we

these contrasts are
or louminute averages; and the changes
in the two groups assessed by an appropriate multivariate statist—
reduced

ical

The standard scores derived from

to either

5—minute

to contrast the changes induced by methadone and leveSince no placebo group is available, the final statements
are limited to descriptions of the changes associated with each
condition; the changes in time; the identification or individuals
who are outside 2 or 3 SD from the mean of the group; and a contrast
of the levomethadyl changes with those occuring after methadone.
Should the changes be consistent with previous experience, it may
be possible for either Professor Roubicek, Dr. Vblavka, or myself to
method

methadyl.

contrast the observations with the data recorded earlier at the
studies.

NYMC

�szmw n:

hhry'Csrol

Newmenn

The

w-vuwu- um..-

-‘

.. .n- 7.. w..,..,.... ..

‘n-nmwr

~3~

w

.7...“

__,.

-w. c,

V. . ..

"I'V-‘mum‘;§~w

'

facilities at the Health Sciences

May

p. —,,.‘.-

n.

we

in.

.....,

,

on. c .,

.....

..

16, 197k

Center

at Stony

these analyses for records provided on compet—
ible tapes. This laboratory is supported in large part by grants
from the National Institute of mental Health and the National
Institute of Drug Abuse. we can, therefore, to the extent these
other funds are available, provide the analyses at reduced cost

Brook can provide

SAODAP.
The 2&amp;0 hours of EEG estimated to be recorded by
Sharon/Burch and the 150 hours by Resnick/Volavke could be re—
duced in 100 hours of machine/operator time at $1¢ui§/951-

to

we

‘f

would estimate an additional 2 weeks of operator time
IBM 370—65 machine time for the statistical ena1~

“”“"EEETIh’hours of

yses provided in this study. Should the analyses requested by the
committee be more sophisticated then re can provide, we can provide
the committee with the data in card format on Hollerith cards or
IBM compatible tape for statistical analyses elsewhere.
.

Our budget should include travel funds for two trips to
Texas by a member of the staff; and two trips to New York. The
option of whether the trip is made from New York to Texas or the
reverse must be left in our hands.

also request an allowance of $4Zﬁ5. for telephone
pend other special charges that may facilitate this proJect.
The budget estimate does not include any fees for the
investigators in my laboratory. We are under contract HEM h2—73-260
and we would use the support of that program for the remainder of
19Th to cover any time charges for the investigators in this labor—
atory. particularly myself~and Mr. Peter Irwin. Should theweproject
re~
‘proceed beyond the December 31. l97h end of that contract,
for
201/month
the
of
operation
of
1975
funds
the
at
rate
in
quest
Mr.
the
study.
Irvin
manage
to
of
the services
Budget estimates are attached, reflecting these suggestions.
Should you wish to approve such a contract. the additional funds may
be added to contract DA hPGOOS, Arthur Zeke, M.D., principal investigator, through the International Association for Psychiatric Research.
That agency is also the grantee for PHS funds fer the program "EEG
and Human Psychopharmscology", ME 2&amp;020, which provides support for
the computational equipment which is needed for the analyses de—
scribed in this memorandum.
we

V

�Mery Carol Newmann

Hey 16, l97h

-h—

I trust these

comments are helpful. We would be pre~
Irwin or another member of my staff to Texas to
staff there in the proper recording of the data for
analysis. It may be helpful for Dr. Stillman or you to visit our
laboratories to discuss the work further. we are prepared to meet
with Dr. Stillman and the investigators to design the actual recording times and sessions to maximize the data for the questions
which are to be answered by these analyses.

pared to send
work with the

tapes;

I

Mr.

am

enclosing a set of notes for recording and identifying

and a budget estimate.
Thank you

for your inquiry.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

Merd

Enclosure

�qua-m.—

wg,‘:va.y""

may 16, l97h

msry Carol Newmsnn,
Max

Fink,

M.

SAODAP

D.

Budget Estimates

for

LAAM—Msthsdono EEG

Analyses

is provided for the analysis of she
single lead pair to be collected by Shsrms/Burch;
and 150 hours EEG, single lead to be collected by Bosnick/
Vblaxka. Analysis by period analysis, l/h real time.“
hours

EEG,

This estimate

Primary Reduction
390 hours

I l/h

x $1h.50/hr

$

1,h00.00

Artefact control

(100 hr x $5/hr)

500.00

Data compression

200.00

Statistical Processing

1—]:

.d'n'r—

"r

Operator time
(2 wk 0 $250/sk)
Computer time

(370/65 s $2oo/hr x

Summary Reports

500.00

hr)

h

800.00

(1 wk)

Travsl

250.00
.

1,000.00

Incidental Costs (tsl.,postags)

250.00

2

arr-r1?!”

After 1/1/75. Personnel costs
20%

x $1,h00/msn

. $280/msh a

8,220.00
IAPR

Overboad Zhﬂ

7.:

a

v'ﬁmnhr

Var-159149:

20.00

“Should power spectral density analysis be
requested, change estimate to a real time
analysis by multiplying primary reduction
cost by h.

.00
$10,193.00
1

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                    <text>April 21,

m. Jovah Simon,

Hoot House

Mominmido

Wm

196%

:4. D.

Flam

10, Scotlmd

Door Dr. Simon:

‘

ﬂank ya: very men for your letter of April 15 end
imuixy, cementing a position as a Research Psychiatrist at
this imtituto. While we have filled our positions for'
January 1, we wmld be pleased to consider an application for
appointnant as of the lot of September 1954. We antimto the
opening of one positim in the research prom in oxponimntal
poydziotzy, under the dimotion of Dr. Sanuel Gorohm.
Dr. Gomhcn has developed an extensive program

'

in

the otMy of antidmolimrgic psychotogons and their blocking
as wall as a clinical otudyo tho treatmonm of mamlc
mots.with
liﬂ'nium ion. In addiucm to those ollmcal program,
states
we have undertaken a oomoo of laboratory omdies in mammals ,
to dovolop now blocﬂdng- agents to antideolimrgio poydwtogeno.
Those coobimd laboratory and clinical study prom have been
in promos since much, 1963 and are well supported by the
Division of Piental maeasos in the Stato of monsoon and tho
Mammal Institute of Mental Health of the U. 3. Public Health
So

oo.

We

antioipato that the position of a Research Scientist

(Psychiatry) wwld be

'1‘!»th
on

this fall, and would entertain an
will be available to cmdidotos on an

application.
pool
visa. However, the position requires
visa or
satisfactory cocplotim on the Marlow Em emotion. With
the DP)! and that ouninotim, the pooition curios an annual
otipom between 313,800 and sm,soo.

ouchango

�*2-

If this positim intranets you. I

would appreciate
receiving a commute Woman: vitae, a small
and the
of at least two referees. I am taking the
of
libarty «missing a wpy of our latest 23mm]. report which
can give ya: a better picture of our program.

Mom,

we

Sinmmly yours .
Firk.
Mmctor

Max
MP

bu

Endlesum 1

M.

D.

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                    <text>Seﬂtember 21, 1964

Dr. Joven Simeon
was: House
Morningside Place
Edinburgh. 10. Scotland
Deer Dr. Simeon:
Your

application for

on appointment

in the research programs at the

Missouri Institute of Peyohietty has been reviewed by the appropriate
oonnitteee and I am pleased that your appointment as Senior Research
of
Scientist (Peychietry) has been approved. subject onlyforto e review
send
us
to
you
your documents. It would be appropriate. therefore,
E.C.F.H.G.
and
D.P.M.
the
photoetetic copies of your medical diploma, the
'

certificete.

do not make nice: your immigration status. In
States
general. scientists from European countriee cone to the United
The
first.
exchange student vise.
either on immigrant visa. or on onbecome
five
after
American
citizen
an
to
elect
candidate
to
the
permits
United
the
in
stay
your: and does not have a time limitation for the limited
to e period
ordinarily
vine
is
student
The
exchange
States.
United
States
the
leave
of five years, and candidates one required to
ins
the
by
for e minimum two-year period before re-entry is permitted
would
this
discuss
migration authorities. 1 would recommend that you
problem with the American Consult Officials in Edinburgh or London.
In the event that you went on exchenge student vile application submitted, we will be pleased to do no.

Secondly, your

letters

cepies of your document, I would
appreciate an indication from you regarding your visa status. and the
time that you would like to join the croft.
In addition, therefore, to sending

no

Sincerely yours,
Man

Fink, H.D.

Director

mills

�</text>
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                    <text>October 28,‘

19614

Dr. Jovan Simeon
West House, Morningside Place

Edinburgh, 10 Scotland
Dear Dr. Simeon:

In order to expedite the application for
it will be necessary for you to submit
photostatic copies of your diploma, D.P.M. certificate
and E.C.F.M.G. certificate. The copies that I have are
not certified and can. not be used. It will be advisable
for you to prepare copies and take them to the American
in Edinburgh asking him to certify that they are
true copies.

preferential visa,

W1

it

In addition,
will be necessary to submit
an English translation of your diploma and this , too,
should be certified by the Consul} .
As socm

as

I

have received these documents,

I will be able to prepare the necessary Migration
application.

With regard to the date of your joinimg our
the
staff,
imigretion authorities tell me that a minim
period for the clearance of such an application is 6—8
weeks. It seems to me that you could plan to join the
Institute early in March and if this is satisfactory with
you I will make the arrangemnts here. I'm looking forward to having you join our staff.

Sincerely yours,
Max

Fink,

Director

M. D.

�</text>
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                  <elementText elementTextId="104521">
                    <text>V.”

.W

v-7." "7

n\—y*V;v-1I.WWV-A'#E‘r~ oawvw

”.7“...

-

y-&lt;:rw:nv:—P~

,...

nr.”m-‘.-

a

«w

-

1- --

-

u-r

r '!

lcbruury 8. 1965
”to

Jun 8““. ”-9.

His: Bout.

Morningsidn Plans
Edinburgh 10, Scotland
Dun: Dr.

Staten:

I: has bath soul Ulik. sine. in racnivud ch. rlqunse thnt
£11:
a prntcruntial-viaa on your bchalf. This has now boa:
a.
dent. tad while I do not hat! the copies of the forms yet tva11~
nbl: to an. I

on taking

thin opportunity to call

you

that th-

aacassaxy scape were accoupliahod horn in Kans:s City.

813cc last writing to you. this Institute hns been tucrxnnisod
as the nu» anarcnnnt o! Paychiaury a! ch. School at Hudicinn of eh.
Uhivurnity of Eilcouxi. With this rcozgnnisution. thaws unuoan aging in matting uh. proper aruduutinls filed. but has new

b0“!

dm

9

I shall write to

yea again

shortly.
Sincnrcly.

81:1:

'tnk. 11.3.
m
Pruitt-or a! Psydhiazry

�</text>
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                    <text>libruary 24.

1965

Dr. Jovaa Bianca. Min.
Vin: House
Noraingnidn Plus.
Edinburgh 10, Scotland

Dear Dr. Bianca:

I an ploasod co ancloaa a aopy of tho Unitad ﬁtneen Doparcunnc
of Justicc notion of approval of via. pctition which indicates th‘t
a copy of this approval has btcn tent to the Consulate in Edinburgh.
Plugs: be it‘s to use this to oxpcdito the aunts-try nrxausnnonts
for your participation in the programs here.

I look forwara to hearing from you.
Sincornlyiyoutl.
Ha:
H1313

Bnmlosutt

tiuk.

H.D.

Professor of Psychiatry

�</text>
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W
w.

Jovan Simon,

smut

Nahum.

10, 1965

24.1).

37/IV

.

Greece

Dam Dr. 8.1mm:

Welodcforward
Myoufovmhmrufﬂays,1955.
toravingymjoinmstaff. Ifyouwillwritetotellmﬁm
datedywurival,waamlmalmmxgmntsfwmatay.

Itmldboimlpfulifyouwouldﬁnusﬁwsizeofyowfamﬂy

wifﬁuymommgwiﬁxyw.

ME My
Hm:

$1ij

Pink,

PM).

meeasor of Psydaiatzy-

�</text>
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                    <text>October 18, 1966

m. Jovan

Simeon

Missouri Institute of Psychiatry
suoo Arsenal Street
St. Louis, Missoxmi 63139
Dear Jovan,

is a

copy of the thiothixene paper which I
have attracted. Please edit this and return it. Ivhave
kept the original and will have Kathy correct
Enclosed

itfor

Wﬂmepeuticlieseamhifywappmve. 'I'hereazea
few

questions. I am also enclosing an earlier copy of the
thiothixom report for you to see what was omitted or
.

changed.

'

.

PleasecheckTableIandtellmswhat toputinfor

to 15 under results. On page nine, the first
four sentences give a vague statement about EKG results.
This should either be expanded to something meaningful

patients

13

or deleted. Please
Enclosed

recommend.

is your copy of the clinical laboratories paper

asitwassenttotheJoxmalofNewm.
Ali has.
fluphenazinev
capy

Kathy sends

that

Pleasedxeckthe

best regards.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

1“ka

�</text>
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                    <text>November 2 , 1966

Dr. Jovan Simeon

Missouri Institute of Psychiatry
51500 Arsenal Street
St. Louis, Missouri 63139
Dear Jovan,

thiothixene paper has men sent to Current Thergpeutic
Research, with your corrections. Xerox copies for you, Ali,
and Turan are being sent separately for you to distribute.
Ponce
The

I have discussed your appointment with the administration.
Since you should cane on a full-time basis, I have asked for a
higher than usual salary (almost everyone is also in practice)

andthishas causedsomeooncern. IwillcallywonPridayin

any case.

it

closerine:

The summary of 10/26

is incomplete, insofar as

does not give the dates and "results" of subsequent treatments.

1. For each
and evaluation.

Itil

patient, what dosage did they have, dates

to emphasize the relation of blood
level to symptom or symptom relief. Would you identify for each
patient three periods according to their blood levels: zero to
MS mgn‘b; us—as Inga;
greater than 65 mgm‘t. 'I'henexamine the
psychopathology scores for affect/mood/ emotion; motor; and
2.

Dr.

wants

oonsciousness/orientation/highermental function. The question:
is there a relation between blood level and the change in these
symptoms?

Prolixin: ok
CyCIazocine: ok
My

best regards.
Sinoemly yours ,
Pink, M.D.
Professor of Psychiatry

Max

mfkp

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                    <text>War in, 1968
m. Jovan Simeon
Missotzri Institute
5400 Arsenal

Street

of Psychiatry

St. Innis, Missouri

.

63139

Dear Joven,

Ali may already have told'.you, themtings in Puerto Rico
quite interesting. Wile there was no discussim of
fluphenezine decamate, there was a great deal of interest in
cyclezocine. There was. interest expense-d, not only in the
effects in mxcotic addicts, but one of my fewer associates ,
"Donald Klein, suggested strongly on the basis of the
data that this oartpomd my lave psydxoactive effects!clinical
What
has been happening with your second
of patients?
I discussed the cycloserine
with Dr. Bennett and
Dr. Cole. Dr. Bennett felt it waspaper
of great interest and
strongly suggested that we go ahead and publish it. I
As

Were

mp

a pmached Dr. Cole and he supported the interest saying that
s oe he had published the basic data from Czechoslovakia he
wmld be pleased to have an opportunity to read the clinical
report. For this reason, would you please let me know what
the present status is of the cycloserine
and EG material.

I

have written another draft of the fluphenazine
paper
and will continue to work on
over

but an unhappy with

tmmxtfewdaye.
so that I can give

it

it
mofthemports

However, Imuldlihe
them to Kathy. to couplete our study.

Mybestregards foraﬂappycmistmsandnybest regards
forethe New Year.
.

.

:.“—&lt;u

Simely‘ yours,

w

gr:

.,

‘aurﬂmpmrp

Mex

Mme

Pitt,

M.D.

Professor of Psychiatry

�</text>
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                    <text>January 18, 1967
Dr. Jovan Simem

Missouri Institute of Psychiatry
51400 Arsenal Street
St. Louis, Miami 63139
Dear Joven,

I was very surprimd to hear of your radical problem and
do hope that the treatnent is rapidly effective.

is

Thankyonvery mob

forthe letterfronm. Merrill.

one of the finest testimonials
most encouraged.

I have ever seen and I

am

IspoketoDr. ItillastniglxtmdlplantobeinSt.
Because of the unusual

It"
Louis

results which you are
finding with cyclamcine, I would like to go over the data with
you ﬂat afternoon or evening and if it seems to be sufficient
for a preliminary report, would like Dr. Itil to release it.
The thiothbnene report has already appeared in the altest
issue of
Thmawéc Rum, Volume 9, pages 10-16.
IhaveaskedDr. Crmxatafwtrereprintsandwill smdthemm
on January 27.

A

to you

CW

as soon as

I receive

them.

Sincerely yours,
Mex

Fink, M.D.

.

Professor of Psychiatry

Hf‘ﬁcp

�</text>
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                  <elementText elementTextId="106688">
                    <text>7333-611

April 9th. 1973
Henry

P.0.

Brill,

Box

22,

M.D..

West Brentvood, H.Y.11717.
Deer Kenry,
Thank you far the envy of the eeeond report of the
Conmiseien. and the eppendieee to the first report. I
have given one copy to Stan, and he thanks you.

I have reed this second report, and once egein wish
to commend you and the Commission for approenhing the
issues with a Judieioueness and evenhendedneee that is
so neeeseary in this time when drug use remains a under
political iseue. I, too, have been frightened by the
rapid development of e "drug ebuee a industrial - univerlity
complex". Rate that I heve added "university" he your
caution, for no time in the twenty yearn that I have been
in research have I seen so many departmental chainmen
Jung on the bend vegan of drug abuse in order to support
empires threatened by e rednetion in training grants.
The emphesis on elechel as a drug of primary

eoncern

of €38

is well placed.

A

few years ego when Earl Ubell

celled
as he wee preparing his series
to Z". he was eurpriseé whee I innieted that
alcohol was a much greater threat end problee.than heroin.
Indeed. when he cheated, he was thin to present e more
baleneoé pieture at drug nee.
"Druge.

wv Have
A

we

Finelxy, I paid special uttention to the Genuinelon'e
attitude to the hermetic antagonists. Althougﬂtthe
reeauaendetione are not these which I heve voiced during
the peat m ywe. I eeneur with the Commission (m. 323-32M
‘

as the beat eonclueien based on the available evidence.

�Brill,

Henry

14.1}.

~2—

April 9th, 1973

Oneo again, I mt to than}: you and the Commission
far having presented ache:- and Judiciaua rocmendationn whieh
I hope the Ana-1cm people will accept.
My

but portend rem“.
Sincerely yours,

I

Max Fink, Md).
Professor at Psychiatry
RIP/1.1

�</text>
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                    <text>m‘w’

mam

..

December 21, 1973
Henk van Riezen, M.D.

Scientific

Develbpment Group

N.V. Organon

Oss, Holland
Dear Henk,

When I received the lettee describing the placebo vehicle,
I read the available regulations. I found none that applied to
IND formulations. Nevertheless, I celled the men at the Division of
Neuropharmacology of the F.D.A., reached Dr. Edward Tocus and
discussed the problem with him. He sent me on to two young associates,
Drs. Kum Kumian and Thomas Hayes. None of the three believed the
question presented a prdblem.

I believe that the formulation is acceptable.
I will

Should you send the supplies to us in the present form,

file

an amendment

to the

IND,

stating that the formulations

used fpr the ongoing studies consist of the type you make available
to me, There will be no objection.

It is probable, however, that should 01—63 come to an RDA,
and you then submit the formulation with a coloring substance, that

the marketing reviewers

may

object.

it

have had severe winter storms here, but
warm sunshine of Palm Springs seems so
wishes for a happy New Year 2
WE

cold today. The
Our

best

is clear
far

Sincerely yours,

Max

Fink,

M.D.

away.

and

�</text>
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                    <text>June 12,

Larry

O.

Rouse,

M.

197%

D.

California State university, Fresno

School of Natural Sciences
Fresno, California 93710
Dear Dr. Rouse:

I have read your interesting suggestions regarding antrainment of alpha activity with hiofeedfsck training and the use
of "reverse tolerance" to LSD for the modification of epileptic
behavior and electrophysiology. The reprints you requested are
enclosed, as are the citations.
While I have no intentioxnof engaging in a long-distance
argument, I would like to question the concept of "reverse toler—
ance". This issue has been raised anecdotelly by street users of
cannabis. we examined the problem and found that tolerance in the
classical sense occurred and that "reverse tolerance" was not a
direct phermscologic but a "set" effect. Are your observations
with LSD sufficiently well controlled to demonstrate physiological
hypersensitivity (i.e., reverse tolerance)? Since heart rate and
pupillary also both change with LSD, perhaps you could use (or
have used?) these objective indices? In our studies of daily ed—
ministrstion of LSD in schizophrenic patients, we found tolerance
development to be rapid, occurring to three daily doses.

I trust these reprints serve your purposes.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max
:

MF:ed

Enclosure

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                    <text>August 3, 1987
Jovan Simeon, M.D.
27 Davidson Drive
Ottawa, Ontario K13 6L7

Canada

Dear Jovan,
Thank you for the reprints and for the advance notice of the article by
Barry Martin. There seems to be some continuing activity in Canada in ECT, both
clinically and in research, and it is good to read of these things as they appear.
Gabe Carlson has taken a firm hand of the child psychiatry service, opening
the in-patient unit, and in encouraging the residents to work with her. Two of them
are taking a fourth year child psychiatry elective and they enquired as to the
feasibility of following the course of. methylphenidate therapy in ADD children
with QEEG measures. lam pleased to cooperate with them, but asked that they do
a literature review first. Considering the long standing interest in this topic, 1 was
surprised by the dearth of reports. Yours are of some help. We will proceed, in any
case.
i will send the Annals back by separate mail. My best regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>April 18, 1978
Mrs. Susan Simeon
Royal Ottawa Hospital
1145 Carling Avenue
Ottawa. Canada
Dear Susan,

Enclosed is a set of notes regarding BEG recording
in a manner that will permit us to analyze the records from the
tapes. When you have questions, call Peter at 516 nun 2560.

It

would be

helpful for

protocol for the study so that
the recordings.

we

us to get a copy of the
can review the time and frequency of

‘

My

regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>April 1n,

1961+

Dr. Alexander Simon

The Langley

Porter Neuropsychiatric Institute

#01 Parnassus Awenue
San Francisco 22, Califbrnia

Dear Alex:

It

would be a pleasure

If

you would

visit the Institute
will

call

his stay here.

David Kbssler

Mlssion 5~5uu5, Area 31%,

make whatever arrangements
My

to have Dr.

on April 20th.

we

that are necessary during

best regards.
Sincerely yours,
Max

HF:
AIR MAIL

Pink,

Director

M.

D.

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                    <text>Ham}:

HI). Harbor-t A.

81m, Ediw

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�</text>
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October 25 , 1967
Dr. Michael R. Simon

New

Jersey State Hospital
New Jersey 077%

Marlbozv,
Dear Dr.

Sim:
is a

copy of the letter which I recently sent
would
add the-rt he has shown himself capable
to
I
of carrying out clinical projects under supervision and I
twat than: he will be able to do so on his own, given the

Enclosed

Dr. Name.

suitable envimmmnt.

Sincerely yours ,
Fink, H.123.
Professor of Psychiatry

Max

Mf‘ﬂtp

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                    <text>—v,_—A

war-1w."

“nu-mu;-

'ij

"ea-”warp

'“““

Septenber 28, 1970
Dr.

Pierre

Simon

Centre Universitaire

Pitie-Salpetriere

91, boulevard de l'Hopitel
Paris (13°), France
Dear

Pierre,

Thank you for the articles on sulpiride. These were
most helpful, and as you suggest, the data is indeed uninpressive.
An EEG profile analysis would not be sufficiently helpful to reply
the expense and effort.

For the

will restrain

Copenhagen, I hope the Program Committee
the ehairnan to, at most, two parallel sessions!

GIMP

Many, many

in

thanks for your kindness in sending the articles.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 3, 1970
Dr. P. Simon
91 bd. de l'Hopital
75

Paris 13, France

Dear Czardas,

It

was a pleasure working with you once again. While the program
was larger than we both wished, I left with the feeling that
meeting was a successful one. I know that my family enjoyed Prague

in Prague

the

very much.

You may

recall that

stand that the

subjects.

The

I discussed

my

compound has a wide range

interest in sulpiride.
of psychoactive

literature is quite confusing and

I am

I under—
effects in some

writing to ask for

any information that you may have available. I would appreciate any preprints and reports regarding studies from your lahoratories. Also can
you tell me who may have carried out clinical studies?
My

best personal regards

United States you will favor

and I hope

me

with a

that

visit.

on your

next

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

visit to the

�</text>
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Dr.
19

more.

SW
Strut

East 88th

New

York,

1966

New

York

mm:
Phyltmthisoppwtmitytothmkymform

fmkdimuim. Itmmstlnlpfulmhugiwnm

mmhtopmdor.

I

look

form to taking an opportmity to visit

youﬁmImMianodc.
Again.

my

thanks.
Sinocmly yours.
MI}:

Hrzjm

F119“ Md).

Profaasor of Psymiatry

�</text>
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                    <text>r—vm-rmme

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33

March 9, 1978

George Simpson, M.D.

Metropolitan State Hospital
Norwalk,

California

90650

.G.M

,ﬁulﬁ

st

Dear Geore¢3sidomaq lo 10389301?

left the wintry East for the
have had a hard time of it, the
snow is still about two feet high on my lawn and the passage for my
car looks like a trench from the first World War.
You must be

sunny west before

._.w.w,_,,‘,..__.

pleased to have

this winter

I We

It was good of you to write. I was sorry to have missed
the session in Louisville but I thought that Hy's solution was
worthy of a trial and I am glad that it went well. The meeting in
New Orleans was a good one, if late in coming. I suggested it about
four years ago, and now that the Task Force of the APA has done all
the work, it was useful to bring some of the clinicians together and
review the data. It became clear as the days wore on that there is
much that is known by the researchers about ECT, but that little of
the information has percolated through to the practitioners or to
the University professors who have interests outside of clinical
studies. Papers by Salsman, Davis, Frankel, and Squire were particularly
outstanding. Some of the analyses were newly done and commendable.
All in all, I think the meeting report will be complementary to the
APA Task Force report and my own volume on ECT, both of which will

r”

..

,..,

appear

this year.

As to Grimm, he is one of the many over-emotional pseudo~
scientists who have an opinion based on limited data, and then re-

interplet the findings of others to suit their preconveived notions.
too strong, it does reflect my opinion. He has made a

If that is

big deal of the concept of kindling, based on animal data, and then
alleged that the dame phenomenon occurs in ECT. It does not since
the parameters of ECT are distinctly different, as I noted in my
report to the APPA and published in the volume edited by Shagass,
Gershon and Friedhoff,on "Psychopathology and Brain Dysfunction".
You have a better scientist at LaJolla, Larry Squire, whose data
should be used in preference to the opnions of Grimm.

x

2'8"

-

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th only did you leave at the right time for the winter, but
the DMH is undergoing re-organisation again; Donald Oken has been around
at the Governor's request to find out why we do so much research and to
find all the 'fat' in the research budget; and we have already been told
that the 1978-79 budget will have a 17.8% reduction across the board.
Do you know of a good Job for a middle-aged psychiatrist in sunny Cal ?

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Prim

":3

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.

Emma

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�1i:

Post-It” brand fax transmittal memo
Co.

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Department of Psychiatry and Behavioral Science

March 21, 1992

George Simpson, MD.
Department of Psychiatry
Medical College of Pennsylvania
3200 Henry Avenue
Philadelphia, PA 19129
Dear George,
lecture material on efficacy of ECT, with slides of efficacy in
major depression, major depression with psychosis, schizophrenia, mania,
catatonia, NMS, parkinson disease, and a few others. There are also slides of
the risks of ECT, considerations in treating the elderly, and maintenance and
continuation ECT. The whole represents one of my two stocks in trade.
I

If

slides or,

if

have

full

you focus your question more specifically,
can find them, send the negatives.

I

will

be glad to copy the

I

Many recent texts give the data in summary form. These include:

Abrams,R. Electroconvulsive therapy. New York: Oxford University Press, 1988,

‘

231 pp.

American Psychiatric Association. The Practice of Electroconvulsive Therapy:
Recommendationsfor Treatment, Training and Privileging. Washington,
DC. APA Press. 1990.
Kellner, C. (Ed.): Electroconvulsive Therapy. Psychiatric Clinics of North America.
14 (4): 793-1020, Dec., 1991.

I will be away this week, returning on Monday March 29. Call me
afternoon or evening at my home/office- 516 862 6651, or in the mornings at the

University- 516 444-2929. I’ll do my best.

Max Fink, MD.

Professor of Psychiatry

state University of New York at Stony Brook
Stony Brook, New “York 11794—8101
516-414141-2990

Fax:

516444-7534

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                    <text>April 30, 1968
Dr. George M. Simpson
Rockland State Hospital
Ormgebm'g, New York 10962
Dear George,
Our data on the laboratory changes was published in the
05 Clinical Phwmacotagy and I am pleased to enclose

Jamal

a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active
drugs in order to provide accurate ooncm'rent estimates of
the usual laboratory ranges. "Concurrent" is the important
term, since seasonal changes and changes in technicians,
m-agents and equipmnt cannot be predicted frun sequential
studies.
Itwas nice seeing

you

in Spain.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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30 , 1968

Dr. George M. Simpsm
Roddand State Hospital
Omngeburg, New York 10962
Dear George,

Ourdataonthe labomtozycmngeswaspublismdintm
mum thcatogy and I am pleased to enclose

Joanna 05
a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active

some

drugs in order to provide
omcmment estimates of
the usual laboratory ranges. "Concurrent" is the importmt
term, since seasonal changes and chmgss in technicians,
m—agents and equipment cannot be predicted from sequential

studies.

It was nice seeing you in Spain.
Sincerely yoLIrs,
Mm:

Fink,

11.1).

Professor of Psychiatry

MP:kp

�</text>
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                    <text>E.._w_,._.,__.-__w,.,,m

m

‘v-"m‘mwwvy‘I-wm—vcv

.n- “um

1"va

7..., ~__‘.._,____

ﬁrm—"w.

.

.

VN...V....7...(

”ﬂaw—war

_.

nwv—vv‘h-VV-m.

“WV—wmmw-w

i
F

Octobu 24,

m.

mu

Goa/(3e M. Simpson

HoAthu
sun
New You. 10962

Rocuand
Ouagcbuag,

0m

Gaugc,

m
mm
bun mud
wanting
a
in Mphyuotogy.

Thank you may ranch 604. the.

have

come,
how in Nave-bu

Wt, 05

cum

«the
who

and how.

Since.

ubwty

u

1

:1de
and the. second in AW
two

1969.

van
mm
mu mm.

06 DA. Hana.
bone a the

0m

cannot (and anothu. petition today, I have taken

05 bending he):

Moguooa as Homology wt

Thank you [all

Making

to

DA.

Whoa

06 me.

My yaw,
Fink, NJ).
Magma a5 Poydu‘atxy

Max

HF: hp

be

�</text>
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                    <text>August 12, 1969
Dr. William L. Simpson

Detroit Institute of Cancer Research
Division of the Michigan Cancer Foundation
48ll John R Street
Detroit,

Michigan 4820l

Dear Dr. Simpson:

are planning a schedule of meetings for the fall
would be helpful to have the specific dates of
the next meeting of the AIRI. Your letter of May 23
would be held in New Orleans in October
indicated that
and we would like to send a participant.
We

and

it

it

Sincerely yours .
Fink, M.D.
Executive Director

Max

MF:kp

�</text>
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"ﬂaw”...w.”

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Dr. Arnold J. Singer
Chairman of the Board
Reed and Carnrick

Kanilworth,

Jersey 07033

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of our proposed presentation, as phoned to

is:

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MARIJUANA. EEG

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AND BEHAVIOR

Jan Volavka, M.D., Rhea Dornbush, Ph.D., Stanley Feldatein, Yh.D..
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M.D. and

Alfred

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for the opportunity to participate.
Sincerely yours.

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Professor of Psychiatry

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                    <text>January 6, 1971
Dr. Arnold

J. Singer,

Chairman of the Board
Reed and Carnrick

Xenilworth,

ﬂew

Ph.D.

Jersey 07033

Dear Dr. Singer:

recent meeting of investigators interested in cannabis,
the proposed program next spring at the Academy of SciencesWewas
have
mentioned as a public presentation of the available data.
the
and
believe
two
studies,
recently completed the analyses of
data to be relevant and possibly sufficiently novel to be of interest.
At a

have established the EEG profile of cannabis as inhaled by
experienced users, in both acute single trials and in chronic (daily
x 22 days) use. Subjects smoked cigarettes containing the equivalent
of 7.5 mg or 22.5 mg THC. The data allows us to classify this compound
we

by
in relation to the EEC profile classification previously published
Of
and
special
others.
1969)
by
us (Ann. Rev. Pharmacol., 2; 241-258.
use ~ changes
interest are the changes in EEG profile with chronic
We
would
behavior.
propose the
which are associated with changes in
and
M.D.
Volavka, H.D.
Jan
Max
Fink,
title "EEC Profile of Cannabis", by
on immediate memory. and the
and
of marijuana. These data
dose
relation of the changes to task
Jones and
differ from those presented recently by Kiplinger,
of Cannabis on
”Effects
of
We
would propose the title
Tinklenberg.
M. Freedman, M.D.
and
Alfred
Ph.D.
Immediate Memory", by Rhea Dornbush,
Our second study

is of the effects

There are two additional issues that are of interest to us
that may be discussed at the conference. In oscwchronic trials, we
have noted a decrease in "tolerance" to cannabis, the subjects
developing dxpphoria after one week’s use. We are assessing the
possibility that smaller doses may be needed after repeated
exposure to achieve euphoria, and the recent reports of persistent
tissue levels of cannabinols may be an interesting contribution.

�.r—

.

v...“

-

.-

.

ww4.v"v.«

2.-

('~‘-'

(Aw—r m...»

Dr. Singer

.

.n-g

.7:¢'v.v-vv&gt;.

.-

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in",

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.

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.12.“.

.,

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”1,.

January 4, 1971

have recently received a contract to study chronic cannabis
users in the Near East, to assess the evidence for persistent sociological,
social, and neurophysiological changes. In working through our tests
we

and sampling techniques, we became involved with the problems of

establishing adequate controls for the chronic drug user.
It may be useful to discuss these two
the problem of
"tolerance" on chronic use, and adequacy of issues,
population samples for
chronic trials, should the conference wish to review the immediate
research issues.
Our programs have been

Institute of mental Health

substantially supported by the National

if our
can
contribute to the success of the proposed public presentations.
my best wishes for the success of the conference.
and we would be pleased

Sincerely yours,
,.

,

Max

7””?va

_.

.:
«
ewe-nun

Fink, M.D.

Professor of Psychiatry

MF:kt

data

,

5

�</text>
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                    <text>wow-w—

.~
&lt;

m

.,

r
w,

u

wwmw.u.r.wn

mwr

”Ir.-

February 5, l978
Dr. ﬂax Singer
Quaker Bridge Road
Croton on the Hudson. ﬁew York l0520
Bear 3r. Singer:

visit

a few weeks ago was a disturbing experience.
The State authoritias wara once again seeking a review of drug abuse,
and the chaice of a team without prior exparience in similar medical
Your

problems. highlighted the bankruptcy of tha existing

ﬁat,

if we

state efforts.

are prﬁsumad to be experienced, what pro rams
burst of activity, I éictated the ant osed

do we suggest? In a

untes.

In reviewing these notes. I am aware of how little we know
of érug abuse - how it starts; the physiological changas; the
pharmacology of the drugs and their antagonists. ggg;_
It is

clear, however, that there art axtensive differences betwean
apiates and cannabis « the opiate dangers are clearly definad;
the cannabis dangers overdrawn and unsuhstantiated. while
intensive research an ogiates is mandatory, a maratorium
a moratorium on imprisonment.
an cannabis can be safely antertained
new laws, legalization combined with an extensive study effert
to answer the cogent questions 9f the suprlies 0f cannabis and
m

their dangers.

cf

against opiates is not too
our nation seems embarked on a 5 billion dollar annual
expenditure against a Chinase threat * is it too much to ask
absurd
$530

Perhaps the analogy

5 “war”

~

millien for

a “Chinese“ epidemic?

May I submit a special plea. for inclusion in your report
regarding opiates? ialoxone in a silastic vehicla is a simple,
direct and feasible aid in treating this disease. The funds needed

�.

Fwy

rm-

-

~r-v-vn

wwwm'mmmm

man‘s-zap

.m-

.-,. .vﬂ—pw,

-. .V. W——M...

.

,

.uW‘wwn.—w

M, s.

"-Yw-ri wawmwx -—u—-~-mv7ww———cw——-.--:

.7“? Team-WV." -V-

-2-

Br. Singer

.......- u.

».

__,_,

“.7 ‘m,——.1_’—.-w.

wvr,....._..

.

WV

vamp—"q...”

February 5, l970

for development may be small in amount ~ we have asked $70,000 the
first year and yet, the promise is so great, that this nominal
expenditure should he "slipped in” among any recommendations. If
successful, the rewards will be most gratifying. If unsuccessful,
—

the loss
I

trivial.

while

would be

of your

understand your report may have a restricted distribution,
qrateful for the opportunity to review a copy with a member
I

staff.

Sincerely yours,
ﬁax Fink, %.U.

vrofessor of ?sychietry

ﬁF:kp

cc:

Mr. Gus Tyler
27 Stoner Ave.

Great ﬂeck,

New

York

.

.

�</text>
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                    <text>.m_ww.m

mmwm'wm

n—wrwaw

4‘:

«2-—

March 20, 1970
Mr. Max

Singer, Prosident

Hudson Institute
Quaker Ridge Road
Crotcn—on~Hudson,

New

York 10520

Dear Mr. Singer:
ouch has happened sinco I received your interesting letter
of notch 12. I appeared beforo Senators Hughes and Javits in
support of a proposed bill (S~3562) to establish a division of HEW
dedicated to a national effort in treating and studying drug
depondonce. Mr. Javita became interested in antagonists and
when

his office called

NINE, they were told that our
was rejected.

contract for a long acting naloxone

is to your questions.

present Facts or

dogma; but

unsolicited

Most are unanswerable according to
here are some tries.

”Craving“ after detoxification as a metaphor, “there is
nothing in his body which one can hope to influence”: There is

that tissue cells

change when exposed to opiates, and
a single exposure, are long lasting.
When animals are exposed to an opiate days or weeks after the
initial exposure, their response (however measured) is significantly
altered from the response of unexposed animals. Thus, opiates are a
some evidence

that

such changes, even

after

potent signal and ono~trial [or fow~trial1 learning occurs ~ with
consolidation of “learned“ behavior very rapid and persistent. Such
evidence supports the view of opiate dependence as a biological
How to induce “unloarning” or forgetting is our problem.
problem.
We need means to enable selective forgetting (g;g;, in such diverse
illnesses an phobias, allergies. penicillin and rﬁ sensitivity,
935;), and the “cure” of opiate dependence may be viewed in this
framework.
By the dictionary, it may not be a ”medical“ problem,
but it is a biologic, not a aociologic, problem.

�nw-w-v—IVWW

»V..-———-.wW——n..—..w

‘W~WW WWW—“WW""a... ,_
.

Mr.

w. .

.

,7 Wwe...

1..

pm_—w.wwmmm. Maw—.wm.

..

.

-2-

Singer

March 20, 1970

The problem with methadone maintenance (and

2

’

.

heroin maintenance)

is that these agents consolidate learning. A principal hone of
treatment by antagonists is that they may serve to reduce opiate
"memories.”

.

H

of ldroin Addiction: A spontaneous cure reflects
some subjects to resist tissue demands for opiates
fer sufficiently long periods to reduce tissue changes by disuse
atrophy. Whether the drive to withstand tissue demands is socially
determined (as in asceticism), physically (as in incarceration) or
biologically (antagonists) may be irrelevant to the outcome of
discontinued addiction. RAV is an interesting term that needs
clearer definition.
The Nature

the ability of

._m.ww_,m,uus

WV.

“Wu—A

.«

Hwy

«r
-.

..v7-—.r‘—vr”mMW-Irmv-——M

Heroin Use and Disease: Some interesting ideas, I have responded
with marginal notes, agreeing with most, and disagreeing with some.
1. A reason for reducing a habit may be expense and strain, but
this sounds like a rationalization. Perhaps, a reduction in drive
for opiates occurs because of hormonal changes (stress, age) or after
an illness which may alter tissue responsiveness.
2.

Like with other addictions, as alcohol, tobacco or barbiturates,
seems necessary to assure availability of the drugs.

social participation
shawl-

cw,-

:wgq.;n~v

Perhaps contagion is re—enforced in opiates because users know
To assure an adequate supnly, they wish to increase their
connections, so that if one connection is disrupted, others will be
available to sustain the dependence.
3.

it is illegal,

”pr

w—

.,

4.

Theoretically balanced, but is there any evidence?
had apple in the barrel analogy is applicable.

5.

Surely, [repeated] exposure to opiates is the necessary

likely, the
,wvwwrwrwmwl

and

sufficient causal factor.
These are

.‘y

”.7,”

More

my

responses.

Perhaps I

am

over-emphasizing the

biological bases of addiction, but this model seems to provide a
better theoretical framework for the study of your questions than
sociologic or psychologic theories.
I look forward

to your recommendations

- which I hope will
some other techniques

balance the psycho-mania and methadone-mania with
for study.
Sincerely yours,
rwﬁwww

:‘zax

Fink ’

:51. D

a

Professor of Psychiatry

Mszp

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                    <text>‘-

mw-wmn-vu

:—

1,:—-.m-

«r»

n;

:45»;

:er

m.

-'V""P‘u'&lt;1"nz"ymu

Hr. Ha: Singar

March 7, 1970

Hudscn Institute
Cratenmen-Hudson, ﬂew York

Dear Mr. Singer,

I hnva read your interim report and apttndices with
interest, particularly since tha viawa are both novel and
engaging. A heroin diﬁttibution system, if faaaibla, may indeed
be a useful interim step in reducing the opiata abuae probleg.
An immediate reaction is raferanta to tha reputed failura of the
Britiih system, and your teviaw of that 'failure' is too superficial
to be convincing. I 3139 believe that our present climate will
not allaw such a system unlass it is encumbered by psychotherapy,
social tharapy, rehabilitatian, gtuup therapy. ggg,~ and this will
increase the costs markedly. Is this not nae of the handicaps of
the ﬂaw York State system, that it pays lip setvica to all systems.
much

having none

at its can i

I wauld immediately agree that tha heroin addiction
ptoblem~is not purely a medical problem, and that the solution
is not purely a madical oat. But that was also the status of the
syphilis, the tuberculasia and the leprosy problems. before medical
sclutiona wart definad. These medical solutions plus tha social
has had tht major impact in raducing the tragedies of these, now
curable, diaeaaea.

Since discussing our praposal for unloxona with you, we
have reviewei tha cyclazocint data, and find that the same approach
is feaaible for this drug as wall~~ that increasing the costs of
our proposal, since two drugs ought-to be studied. We are not
optimistic that either the ﬂaw York State nor the National Institute
of Mental Eaalth will provide fundu~~ both have said all the nice

things like the idea is excellent and tha awed is great. BUT . . .
differ in their ”BUT’S"? the results will be the same. we have
aleo made a presentation to the lawyers cf the Vera Institute, who
alao spoke highly at the ideas but "BUT«TED” the possibility of
They

tunding away.

�Max

Singer

0..HOODGIO.QiﬁtboblotOO‘OIOOIOOIOOOUOOMarch 7, 1970

principal question of your letter relates to the
of
channeling
opiate users to other substances if a concerted
governmental action inhibits the use of heroin. Indeed, that is
likely. Let us suppose that the heroin (opiate) use is severely
inhibited, and marijuana use increases markedly. So long as the
penalties for marijuana uoe remain the same, the results iutterms
of crime will be the same. But is it necessary to maintain the
fiction that marijuana in as deleterious as opiates ? I have
worked with both types of substances, and have read the literature
carefully. There is no relation in pharmacology or physiology
between the substances. One is Beverly toxic to the body, causing
extensive chemical chengeo that persist for weeks, months and
perhaps years; the other, minimal changes, of a transient nature.
Deaths do not occur with cannabis; they do with opiates. That is a
sufficient basis for me to consider the channeling of opiate users
to marijuana to be a social good, not evil, in the present climate
(provided the penalties were removed for marijuana use).
The

for the ’soft~drugs‘, here too, the pharmacology and
of
physiology
methedrine, amphetamine and the barbiturates are
sufficiently unique that the distinction from ooiatee is easy.
Addiction may occur, but deaths are lose common; dosages necessary
are very large for fatality; and while I am not so enthusiastic
about channeling to these drugs from opiates, I consider them
eo much less damaging, one addiction so difficult to achieve, that
e ‘uer' on opiates with a resultant increase in the abuse of
these drugs is still a useful 'wer’. (In the balance of nature,
the abuse of these drugs seems less commonly achievable than the
abuse of alcohol, and we have been able to live with that abuse
as a nation.)
As

-

You mey be pleased to know that the National Institute
of Mantel Health has looked upon our suggestion that a team of
atientiote be sent to Greece to study chronic (20»30 year) heehieh

users with

some

favor, and called to any that that contract will
effort to obtain some

be awarded effective June 1. This will be our
data on chronic cannabis abuse (use).

for the comments, the questions, and especially
for the preliminary reports with their novel (7daring?) suggestions.
Thank you

Sincerely yours,
Fink, M.D.
Profeaoor of Psychiatry

Max

mf/

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                    <text>nunsawv Wm—“

w—w w

'm.‘-1'1‘

,

-

,

May

:

}

‘

l

i

E

.W

,

“‘\.n.'~.

16, 1970

Mr. Max Singer
Hudson Institute

Croton~on~Fudson, N.Y.

Dear Max,

E

k

E

E

‘

r

l,

I have read the "First Draft of Final Report”, dated

interest, enthusiasm and some eventual disappointment.
Interest, because the report is well-written and some expressions(such
as the need for better enforcement against heroin) are clearly stated.
Enthusiasm, because I know the problem is urgent and any thoughtful

Hay

1970 with

approach should be listened to with care. Disappointment, because I
find the medical aspects treated tritely, even diffidently, and with
an immaturity that casts doubt on the value of the effort. Perhaps my
original doubts are re-enforced by this report. Let me give you a few
examples.
"Moreover, physical damage from even

protracted use of heroin

is rarely serious or irreversible.” (pg 16,par. 1); and, "Current addiction
. . . . is a dﬁseaee one can treat, and in most cases is not terribly
serious even if untreated." (pg 19, par. 2). What fatuous comments !
Death is irreversible, and death is an ever~present aspect of opiate
dependence. So is liver dysfunction and heart disease and post~traumatic
}

g

‘

brain disease. Your views of opiate dependence are the views of the
upper classes who rarely saw the dangers of syphilis or tuberculosis,
diseases of 'those other people', and therefore could say that they
were unimportant—~ until it affected their children. Heroin addiction
is a serious, fatal disease, especially among the young.

seems likely that many or most of those who take up heroin
are weal or immature personalities, perhaps psychologically dependent
types. It also seems likely that the addiction experience strongly

"It

reinforces the tendency tpvard immaturity, weakening the character of
those who might have been stronger when they began." (pg 19, par 1).
There is no evidence for these views, and they are eqyllly fatuous.
How

does

it

help to see the

ill

as "psychologically weak" except to

superiority. I suppose it makes you feel better, for after
not
addicted, therefore you must be 'strong' or have a
are
you
all,
'mature personality'. Come off it, Mr. Jack Armstrong, All—American
assert your

own

Nixon hero.

There is more. I am disappointed that we know so much that
research is not needed. I am delighted that there is little danger
of methadone spillage, especially if the delivery system is computerized.

more

-ps

�WI" We."

.

351w

-

mm,-

W

.

){ax

,

Singer OOOIOOIOOC-l-QOODOI...P8882

w

1W wmrmww:WH-+r

mv~w¢rmau~z("4" ‘W“&lt;:Vm"rm

COCOOOCUODOOCOOIOUBIay16’

It is valuable to

know that a methadone delivery system can be
and
indeed could eventually replace off~track
self—supporting,
as a source of state revenues.

"Wm—W

Remind me

1970

betting

There is some hppe in the future, I am glad to see.
to have faith in the democratic process, if does work.

"WWW.

v...

I

thanks for sharing this preliminary report, and
sure you will appreciate the candor.
My

WW...

am

..

My

Wmvvaum

best regards.

_-

--

Sincerely yours,

E

Max

Fink, M.D.

Professor of Psychiatry

[

mf/

P.S.

Truitt position paper on legalization of marijuana is
equally trite and superficial. The issue is not the medical
data on marijuana, where I agree we need more information, and we
are participating in obtaining the necessary data. The present crisis
is the disparity between the severity of the legal penalties for
marijuana use and possession and the complete lack of evidence of
any harm from occasional use (or the harsh comparison with alcohol
use and its prominent medical complications). The political issue
is in a relaxation of legal penalties for marijuana use and the
clear separation of its relative safety with the severe harm of the
The

opiates.

"1'

~.

w«unm.~n~vw~

many-r

�</text>
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                    <text>7385*75333

12 Bovcnbcr 1973

3313.11 Gordon. Ph.D.

3:13:01 Liberatoricn

P. 0. no: 657

Syracuse.

Butt

Haw

York 13201

Max:

Your progress with Voluno 3 is enunnnddblo. I htvn abackcd
the tgxt of my aontrtbution sud find that I huvh not taprodueod
nay mutatinl which has bean pnblichaé ptuviously in an idonttn
tiabln fashion; n» toqunst to publiahcra for petuinnian to re~
pradnnn Eh. nicotial is nacanacry.

in

I an tnprculad with ch. alcuably of fin: pharmacologiues
which you hﬂﬂl placad no. and I wish to thank you.

But mums,
sineotnly youru,
Max

rink,

M.D.

Profaaaor of Plychiatry

�</text>
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                  <elementText elementTextId="106982">
                    <text>December

2,

1975

Dir. Ken 8.101111

Dupartnont of Public Safhty
lhh - Administration Bldg.
SUE! at Show Brook, 3. Y.

Room

In:

ARA

momma,

Md).

Dear Mr. 85011.11,
The above-named

is a

member

of the

Mutant

of

Psychiatry and Behavioral Science and as such should be afforded
a parking

sticker for tha

”Y"

parking

lot.
Sinmmly your: .
Fink, M.D.
Professor of Psychiatry

Max

KF/mr

�</text>
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                    <text>T,,.

.14,

,_

“mm, ,

-~

NJn-na-nmnrrrw

mirrﬁh—iﬁwvm

wuaqﬁaﬂ

wwwwzmm»ww "W"

4, l970

Universily Clinic

Allan+a, Georgla 30322
Dear Cr. Skellon:

Enclosed are some of our recenl reprlnfs, including a copy
of fhe Q~scale reporl. The Techniques for cyclazoclne are
dascrlbed ln sufflcienl defail To be useful. Cyclazoclne can
be obfained from Sferlingnwlnlhrcp Laboraforles in Renssalaac,
York. Naloxone is no? available for Trlal.

New

You can ”lune ln” cyclazocina by using fhe scale and
lnducfien schedula, and as paﬁianls are in freafmenf, revlewing
fhese wifh us. We would be pleased +0 have you vlslf us, or have
one of us consul? wifh you in Allanfa if you wish.

Sinceraly ycurs,
Max

Fink,

M.D.

Professor of Psychlafry

"r.

1‘

.

Dr. w. Douglas Skelfon

Emory

'M.

v

.rrw,» “a“, ,.

May

«y-

.vwvnvx-my.

1,3;

NF: k5)
GHC.

�</text>
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                    <text>‘

ﬁ

f. ‘1

May

Dr.

W.

4, i970

Douglas Skeifon

Emory University Clinic
Allanfa, Georgia 30322

Dear Dr. Skelfon:

Enclosed are some of our recenf reprints, including a copy
fhe
of
Q-scale reporf. The fechniques‘for cyclazocine are
described in sufficienf defali To be useful. Cyciazocine can
be ob+ained from Sferling-Winfhrop Laborafories in Renssalecc,

New

York.

Naioxone is no?

available for Trial.

can "fune in" cyciazoclne by using the scale and
inducfion schedule, and as pafienfs are in Treafmenf, reviewing
These wifh us. We would be pleased To have you visif us, or have
one of us consul? wifh you in Allenfa if you wish.
You

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
MF:kp
GﬂC u

�</text>
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                  <elementText elementTextId="100736">
                    <text>December 28, 1962

Boleslaw Skowronoki

130 West Mch

York 19,

New

Street

New

York

Skowronski:

Dear

I thank

for your recent

vary
I have withheld from roplying until
letter.
knew whether I would be in New York in the
yOu

much

I

near
writing to

future. As thio seems unlikely, I am
indicate that there are, indeed, a number of‘
opportunities for peroonnol in the laboratories
in St. Louis. However. the principle experianoo
reflected in your ourriculum vitae is in microbiology. Suoh a laboratory is not being established
at the present time.
I would be grateful to know the kinds of
experinnoe you have had, with specific reference
to such questions: What biostatistioal Operations
have you carried out?
.

»

to

In what laboratory procedures
pharmacology are you proficient?

do

in a psychiatric hospital setting?

What

related

kinds of work would you like to

Again,

my

thanks for your inquiry.

Sincerely yours.
MISSOURI INSTITUTE OF PSYSHIATRY

Max

Fink,

Director

M.D.

MF:bk

Please address

all

oorrospondence to:

suoo Arsenal

Street, St.

Louis 39,

Mo.

�</text>
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                    <text>January 27, 1985
Petr Skrabanek, Ph. D.
Department of Community Health
University of Dublin
196 Pearse Street
Dublin 2, Ireland

Dear Dr. Skrabanek,
It was kind of you to send me a reprint of your arguments on the
biochemistry of schizophrenia. As before, I enjoyed your review. I have little faith
in the present biochemical or animal models of mental disorders, but they seem
necessary steps in our learning. Both Horrobin and Ackernecht reflected my
appreciation of the problems.
I had already cut out your note in Lancet on "Holy Dread" which
found delightful.

I

also

you will see from the letterhead, I have succumbed to temptation and
the
invitation of the publisher of Raven Press, Alan Edelson, to edit a
accepted
journal CONVULSIVE THERAPY, which is a quarterly, with the first issue to
appear in March. While most of the space will be dedicated to refereed research
reports, there is room for innovation. ECT has just passed its 5lst birthday, and its
very persistence is a challenge to our understanding. For almost three decades,
research interest lagged, but lately there has been a re-awakening. In 1978,
Timothy Crow challenged the belief that a seizure was necessary to the outcome
and thereby launched six or more studies in Britain. While most observers now
accept that either the seizure or something accompanying the seizure is necessary
for maximal antidepressant effects, Tim still believes that good nursing care will
do as well. There are other beliefs which are as contested, not the least of which is
the range of theories of the antidepressant efficacy of ECT. The two principal
(‘serious') theories are those of Grahame-Smith, Costain, Green, and Modigh on the
neurohumoral theory; and Ottosson and myself on the neuroendocrine.
As.

I do not know how much experience you have with the ECT
process, nor
whether it is a feature of your University landscape. But should you wish to tackle
the ECT beliefs, consider a contribution to this new journal.

My best regards.

Sincerely yours,
Max Fink, M.D.
Editor

�</text>
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                    <text>T0:

Mr. K. Skrlvanek

FROM:

Dr.

Max

DATE:

May

19, 1969

Fink

SUBJECT:
.v'.wu~w—

Nvm—‘V—m-W‘WI’WTIWW-"T

rm...

is wtfh greaf regref The? received a cepy of your
of
laffer
restgnaflon. Your associaflon with This Dtvislon since
your appointmenf Two years ago has been 3 mos? useful and pleasant
one for me, and The pafients and sfaff have beneflffed from your
in?eres+ and enfhuslasm.
IT

My

,.._

hes? wishes In your

of Mental Hyg!ene.

sum-W

w-v-Vrv‘vu,

I

MF:kp

new

poslflon wlfh

The Deparfmenf

�</text>
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                    <text>October

Joseph

911111.311:

Slap.

M.

155,

1963

D.

Assistant Professor 0f Mudicinc
and of Psydxiatry

Baum Medical Collam and
Whisk
230 um Broad
Strut
Philadelphia 2. Pennsylvania
The

I-bspital of

Dear Joe:

Ishmldheplsmis tomoommndym formamhip in
numbers
mlikaly that

the C.I.N.P.

3mm. it

tumor

for

C.I.N.P. will be subsequently selected, exacpt {cm those who
hold mmbcmhip in the local - mtimal society, where such a
society exists. I have just looked
the AC"? Roster and
do not find year

m.

my:

I would. mamfm. remnant! that you
joining
this organization first. I wmld be pleased tomid»
mmnd you
forthisgroup. Ifyouudahformtodoso. pleasesendmea
copy

of your

Woulm vita.

811103313: youm ,

Max

Fink,

Director

M. 1).

�</text>
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                  <elementText elementTextId="104353">
                    <text>May

2, 1991

PhiIip SIavney, M.D.
Department of Psychiatry

Johns Hopkins HospitaI
600 N. Woife

BaItimore,

Dear

MD

Street

21205

PhiIip,

It was kind of you to recommend The Life and Work of Josef
Breuer. It was difficuIt to find, but I am deIighted that I finaIIy got

it.

The picture of Viennese medicine at the turn of the century
much
Tess
a few decades ago
is
idyIIic than the anaIysts portrayed
I
I
(when
sat at the feet of the anaIysts). appreciated the notes on
Anna 0., particuIarIy Breuer’s case history. The emphasis on opioids (my
own) is Tess c1ear in this text, aIbeit stiII present in sufficient
detaiI not to vitiate my argument that dependence was a feature of her
’dis-ease’ and many and prolonged hospitaIizations. In my defense I see
in these notes, and in some others from that period, a reminder of our
present attitude to anxiontics and hypnotics. Many patients are

to read

it

admitted or referred to us with detaiIed notes about their use of TCA,
anti-psychotics, Iithium, carbamazepine, a1cohoI, and cocaine, and
onIy passing reference to the prescribed aIprazoiam and f1urazepam.

MAOI,

Andy and Laura are doing weII. They proposed a ’smaII study’ of
as a mode] of maintenance ECT which we are able to fund from a
gratefu] famin. The parents are wi11ing to support this research even
ECS

though they admit that our course of

IittIe reIief.
i1] patient

ECT

for their daughter

gave her

Andy aiso has become interested in a high risk medicaIIy
with a very recent repaired aortic aneurysm who was

successfuIIy treated with
Thank you again

ECT.

for thinking of

me.

My

best regards.

Sincerer yours,
Max

Fink,

Editor

M.D.

�</text>
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Ausust 7 . 1975

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Ivan

W.

Sletten,

M.

D.

Professor and Institute Director

School of Medicine
Department of Psychiatry
University of Missouri-Columbia
ShOO'Arsensl

Street

St. Louis, Missouri

63139

Sletten.

Deer Dr.

I am replying in a formal manner to your letter of inquiry
regarding Jan Volarka, M. D. It is not clear for what position he is
being considered, but he is an excellent candidate for the position
of Director of the Institute.
Dr. Volsvks Joined

~College in the £311 of 1968.

staff at the

my
He came

medical
as a well-trained psychiatrist,
New York

neurolOgist, and electroencephalographer, with extensive research
and
experience. Within a short time, he established‘collaborative When
independent research projects in the areas of his competence.
I left the College, it use a pleasure to recommend him to assume
responsibility for the EEG programs of the Depehtment.

In addition to mastering the English and Spanish languages that are necessery for his work in New York City, he has become
fully‘sccredited in psychiatry by the American Boards and has become

licensed to practice in

New

York.

Dr. volevha is a keen researcher, well read and well
trained, capable of independent and collaborative research. He is
an excellent statistician, in addition to his training es s physi—
cian. He is well liked by his co~workers, is able to establish good
relations with patients, and an excellent teacher.
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‘1‘.

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,
4.,

.

r
A,

,
_,

«Trump—y;n..—‘mriv.,,,ne.l.,

w‘rivl'vm‘ﬁr

w

urn:

a

inr“

Ivan

Sletten,

W.

M.D.

-2-

.

8/7/75

we have published together. and in this relationship I
him critical, independent, and e perceptive student of
found
have
the literature. I know his family, and while it is difficult fer
me to conceive that his wife would be willing to share the rigors
of St.Louis, she is an outstanding student and athlete, being a
world champion in tennis and skiing. He is personable, Joviel,

herd-working, sensitive, and enthusisstic.

He is an outstanding‘candidete for the position.of
the Institute and I commend him to you for that posiof
Director
deem it an honor to hive him assume the title which
would
tion. I
I relinquished some years ago, with the'full knowledge thatofhis
training and experience would serve to carry out the type
clinicel—electrophysiologic investigations_for which the Institute
has become known under the aegis of Turen Itil, George Ulett, and
myself.
.

.mv-«W._—~.~l_m,_..i

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

*1!

�</text>
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1971

Dr. R. Bruce Sloane

Temple University
Health Sciences Center
Department of Psychiatry
Philadelphia, Pennsylvania 191b0
Dear Bruce,

I would like to send you a copy of the SBP report, but it
is still in preparation. For the meanwhile, you may wish to
read the enclosed preprints of our recent studies of unilateral
ECT and a progress report of the ”MEET.
The SBP
when
copy

it

report will

be ready by May

1

is completed.

and

I will

send you a

Sincerely yours,
\

ﬂax Ylnk, M.D.

Professor of Psychiatry

HF:kt

H

£5;

�</text>
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e

.4

“.Ve-nww

ymmv_‘

”v...

May

“ﬁn“

11, 1971

.,
.

Dr. R. Bruce Sloane
Temple University

Health Sciences Center
Department of Psychiatry

Philadelphia, Pennsylvania 19140

Dear Bruce,

is

Sorry for the exchange of reprints. Charlie told Ie that he
narcotic committee at EPPI. Perhaps he would like the

on a

antagonist data.
The ECT

reports are enclosed.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

�</text>
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                    <text>May

11, 1971

Dr. R. Bruce Sloane
Temple University

Health Sciences Center
Department of Psychiatry

Philadelphia, Pennsylvania 19140
Dear Bruce,

is

Sorry for the exchange of

on a

narcotic

antagonist data.
The ECT
.—~.

committee

at

reprints. Charlie told

EPPI.

reports are enclosed.

.31,

Sincerely yours,

.

ru’,ngz.:r;.v

W

41..

Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

me

that

Perhaps he would like the

he

�</text>
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                    <text>.

.

Jammy 18,

"mam-w

V:',vc"nmu'.

4""

1968

Miss Karen Slotky
Copy Editing Department

Meal

American
Associatim
535 North Dearborn Street
Chicago, Illinois 60610
WWW»7«W‘&lt;1'z‘waywavxe-ww

A

Dear Miss Slotky:

I am writing with regard to the report "Long—Acting Depot
Phenothiazim Treement of Psychosis." My associates in St. Louis
have reviewed the paper and I an enclosing pages which they feel
warrant correction.

_
«ray-W

'W

'

The page nunbers referred to are your page numbers, marked in
the upper right hand corner. On page It, the last line of paragraph
lshouldmsd’WtoQSmeks." InpamgraphZ, tmelinesfmthe
bottan delete "(Table 2)." The last sentence should
be changed by
deleting "disoonfort and secondary" and replacing by "eutrspyrmnidal."

'I‘i-‘AWUW'TW

64"

l'.

On

page 5, the paragraphs require a few changes and these are
the attached page 5.

marked on

principal changes are in the results and I have taken the
liberty of retyping pages 6 and 7. Following your editing, please
use these to substitute for all of 6 and most of page 7 up to the
portion marked secondary effects.
On page 8 , we Nomad suggest that paragraphs be deleted foam
the section starting "10 patients in group Eb" and "9 patients in
The

group 2" .

Similarly, the section on page 9 "there was no weight loss"
is logically a continuation of the previous paragraph.
_

In the smmsry, in paragraph 2, the third line should be
charged to read "discmrgeable, and seven did not improve. The”

(the

word secondary should be

deleted).

�-2-

Miss Slotky

January 18, 1968

Finally, the tables have became inverted and table 3 should
2 and table 2 shwld be marked table 3. m1: is,
2
in Individual Symptoms with Fluphenazine
"Changes
table is
Decanoate" and table 3 is "Mode and Outoane of Treatment."

be mrked table

Thank you

for your cooperation.
Sincerely yours ,
Max

Firm, M.D.

Professor of Psychiatry

MF:kp

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                    <text>v

January 10. l968
Miss Karon Slotky
Copy

Editing

ﬂepartment
American Monica Association
535 horth Deartorn Street
Chicago. Illinois 60610

war

~wwm..wr:wrmwm-

Dear Kiss Slotky:
I am returning the text of our report ”Longuncting Depot
Phenothiazina Treatment of Psychosis,“ which is to appear in
the forthcoming issue of the Aachivea og Gaaaaat Raychzatag.

rsmuv'u

Please change the

0:"

Wm.”-

The

«v.3,-

.A-

name

of the coauthor to Turan

M.

Itil.

M.o.

address listed is a permanent address.

V.

wm.

With regard to the reference now numbered l6, this appears
The original text is incorrect and reference l5
ei
page be 2t.
0:
s.ou
.

l967

l 0.

The personal communication

of reference

There are minor corrections in the
In Table

text

11 was

oral, July 22,

on pages 1, 2. 9 and

”yaars" for average number of
ambiguous. That should be deleted.

I, tho subscript

hospitalizations is

In other regards the

text appears correct.

Finally. I believe the layout can be improved. The layout
shows the report beginning on the left side of the page. This
is awkward and if at all possible. perhaps this report should
two of the results and the
start on the right side. Paragraph
4
do
go together. If we start on
figure which now is on page
a right~hand page than the first paragraphs of the rasults
will appear on a page facing the figure. I would also suggest
a realignment of those pages so that tho figure and the legend

�Miss Slotky

«2-

January 10, l968

appear on the upper left~nand side. in the location on page 3
where Table 1!! now appears. By continuing the copy so that
extends on the loner half of the left column and the upper

it

half of the right column. Table
of the right column of page 3.

111 can occupy

the lower half

For page 4. Table IV might suitably occupy the upper righthand part of the page so that the text fills in the left side
and all of the left column. The comment would then appear under
Table IV and would continue to page 5. It would not be necessary
to change page 5.

if

the recommendations for page

The

reprint order is enclosed

are unsatisfactory an:
in the lower half of page 4
filling out the right-hand corner, allowing the copy to complete
the left side and the upper right part of the page.

alternate approach is to

h

,

“am“.

,.,‘.

.—

_-;&lt;«

.n
.urv

_

-,
:-

will follow.

4

have Table IV

and a formal purchase order

r,

Thank you very much

“urea-wry;

for your assistance.
Sincerely yours .
Fink, ".0.
Professor of Psychiatry

Max

MF:kp

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                  <elementText elementTextId="105344">
                    <text>Decanber

I». Victor Slomiok

McNeil Laboratories,
Caup Hill Road

118,

1966

Inc.

Port Washington, Pennsylvania 190314

Dear Dr. Sloﬂlick:

Recently, Dr. Heweon was kind enough to write regarding
a population of patients with mental retardation that might
be cardidates for vial with haloperidol.

Mlcalled,lindioatedtlut1mu1dinquimatthis

College and did so. While there are pOpuJations available,

Ihavemtbeenabletoenlistthesuppmtofamembwoftm
.stafftomdertakeeuchastudyatthistime. TheDapertment
of Pediatrics indicated that they might wish to reward a
pediatricianwlymxtyear. Inﬂueventthatsuchestaff
pwsonisaveilable,1willmitetoymagain.
'mankywverymchforyomintemst.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>January 12, 1972

Drs. Ivor and

once Small

Indianapolis School of ﬁcdicine

1315 West 10th Street
Indianapolis, Indiana
Dear Dru. Joyce and

46202

Iver:

«a..-

,-...,..—_A

.,

-m...._,

an,“

of

I want to thank you for your contribution to the issue
in Pzgchiatdy. I am grateful for your couperation,
pleased to make available 100 reprints of your contri-

8£m£naAA

and

I

am

bution or

my

expense.

If you nave already ordered
change your order with this in mind.

reprints,

you may with

to

I harm your suggestions for title changes for the ECT
seating in April, and as noon as I have an opportunity to review
those with the program connittce, I will answer your letter more
spocifically.
My

boat rcgards.

Sincerely yours,
ﬂax Fink, M.D.

Professor of Paychictry

33:13

�</text>
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                    <text>'*

V"“'I~=-Mr'l"-

‘Ww-w.--r-» w“"“‘7&gt;

’7'”!

.~—-r—w..—.—».‘.V.

._

“Pa“ ~r—P—vry—v-r-r'v‘m ,..,.., ,,

m, .e

.. w.

,

.

or

.

”ﬂue-”myK. .

,

.

r» ,_,”_,, r.-.“ V."

_

..

m“

r

r

TSIzohhct
12 February 1973

Iver Small, M.D.
Professor of Psychiatry
University of Indians School of Medicine
Indianapolis, Indiana
Deer

Iver,

have finally settled on a publisher for the ECT volume:
v.3. Winston Sons, who have promised to issue a hot-type, hard cover
copy by September. In reviewing your contribution, Ihhalant convulsive
Therapy, we have made some editorial revisions for matters of uniformity
We

&amp;

of style.

'Indoklon'

has been replaced by flurothyl;

rating scales are listed without capitalization (pg 3); and,
trade

names

of other

compounds replaced by generic or

listed in parentheses for identification only.
With these minor changes,

publisher, and
my

trust that the

changes

it

on to the
meet your approval.

I have sent

will

thanks for your contribution.
Sincerely yours,
Max

Fink,

M.D.

N

r

,

�</text>
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                    <text>m

—.

n

wwnuwam

ww,j—v‘r'r,4

q’w—‘lvw

.
w
v—

‘W’v‘rw-rv'w“"'

,.,_ un- ~-.

wr _,_ wwl' «_ t...“—7 _,_Wm

ammm W mt. _ mm.
I

,_,,

'r-u'.

x

.

_..m....... u...‘ «qr-v.”

.... v

w"

.w—w

wlw-‘wr.m-1nm&lt;\m‘&lt;~—_ ..m.....—.~.._...w...,..W” .mwv

January 22, 1976
Iver Small, M.D.
Secretary, Society for Biological Psychiatry
Indianapolis, Indiana
Dear

Iver,

First, let me thank you for the invitation to participate
in the workshop on ECT at the WCBR. I thought the session well
attended, the questions excellent, and the presentations served to
alert this audience to the interesting possibilities in ECT research.
Paul met me for dinner that evening and we were able to discuss the
many problems in California and the possible resolutions, which he
may bring up at the task force meeting.
I am writing on another matter as well. For a number of
years, Don Klein has been active in trying to arrange a meeting of
interested learned societies to bring the benefits of biomedical
research to the attention of society. He has alerted me to his
efforts which I strongly endorse. He has asked me to solicit the
support of the Society of Biological Psychiatry.

I enclose his letter to Jolly West, and ask that you
bring up the participation of the Society in this worthy effort
the next Council meeting. I am confident that you will have the
full support of Charlie Shagass and Arnie Friedhoff.
Many

at

thanks.

.nrw.~nm-Wwvm

Sincerely yours,
-

v

nv‘wu

emu

Fink, M.D.
Professor of Psychiatry
Max

M—wm

N...

�</text>
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                    <text>73$B~808SB

11 Doccmbor 1973

Thelma Jonas, M.D.

8

Harvost Drive

Scaradalc,

New

York 10583

Dear Thelma:

Pleaaa accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Micropolitan
Hospital. I have found your enthusiasm and cooperation invaluable in supporting our explorations into new usos for untried
drugs. Without your help, our evaluation: of onloxone, onloxono
pamoate, lcvomochadyl. ctclazocino, and many others would not
have been successful.
'

My

boot wishes for the health of your family and the suc-

cess of your practice.

Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

HF/cia

�</text>
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-—nvw~wwa——-—w—p~

—
~

731:0h30t

-‘=r

"vrrw—

1...

.

W

12 February 1973

”pp—"Ar...

yaw

v
wy'ur

w

mu...-

my!

4;

w-wr

-..

Joyce Smell, M.D.

Professor of Psychiatry
Indiana University School of Medicine
Indianapolis, Indiana
Dear Joyce,

.4

Having

"guzz-

wrrwnpr

van

finally settled

on e

publisher,

we

have edited your

contribution to the BOT symposium, EEG and Neurophysiologioal Studies
of‘ConvuZeive Therapies, according to the style of the volume. There
are a number or changes which I have introduced, chiefly:

warm-gar"-

'Indoklon'is replaced by flurothyl;

aw

1W"-

for 'shock' end'electricel stimulation', on appropriate
of unilateral electrode placements;

:WUIIV'

:Hv

”-4:

amyl-

1'7,m‘

w-wn'.

..._.:..~

phrase embodying the concept

citations updated including Volevke et a1 (1972) instead of
et el (1970) on page 10, and a fuller citation for MerJerriaon;end,
deletion of the last line of the discussion as gratuitous in
the written text.
I trust these changes will not be of consequence, but they
date is
some
will allow
greater uniformity of style. Publication
&amp; Sons, who have
V.H.
Winston
and
the
is
puilieher
set fer September,

Abrams

promised a hot type, hard cover book with a low cost to the buyer.
My

thanks for your contribution.
Sincerely yours,

um-

‘

“qr

2.25211

7
"'

WW»,

v-VW'VP

Max

Fink,

M.D.

�</text>
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                    <text>7583*08088

27 February 1974

Peter J. Fell,
Head

M.D.

of Modicsl Affairs

Fianna Limited

Bnkowoll Rood, Loughborough

Lsioestsrshirs, LEll

OQY

ENGLAND

.Dsar

Peter:
accommodate Tony Croft in our ls~
during tho second half of Mirth. w: will set up a

would be pleased

We

boratories

program which

to

will ineludo observation of our data collection

and data analysis methods, experience in running oxpsrinonts,
and an opportunity to srtofact rscords. Ho may loatn as much

as he wishes about the data analysis, including the statistics.
be spproprinto. we will also go into dstsil with toShould

it

I left anything out?
to visit other laboratories while he is

sard to the behavioral data analysss.
Do

you wish him

here? If so,
.

till he make

Have

the arrangements or should I?

to accommodations. I boliovo he would enjoy the Three
Village Inn in Stony Brook. Rooms cost 312*15 per day. Other
imitations" and have slightly
‘hostslrios arc all~modnrn "ﬂiltonaccommodations
wish
at the Inn or
Should
you
tariffs.
higher
the othar motsls, please let me know.
As

‘

;
'

N

you give him the sons instructions that
you~~to phonn no at 516~644~2447 in the
(daytime or, svonings, st 516~751~é665 or 516~466—5544. I will
probably suggest that he take s limousins to Stony Brook or
Great Neck, depending on whats I so.

I

would ask

that

I originally left for

cal-

�w.

75:.

wwwv—Ju-ﬂqv

wuv

P.

J.

F011, H.D.

-2~

27 February 1974

In confirming these arrangements, 1: would bu helpful if
you would give mm can: information as to Mr. Croft’s background
and training, as well as spacific additional quaationa which
should bu studied whila he is here.
my

bunt regards.
Sincorcly yours.
Fink, M.D.
Profcsaor of Psychiatry

Max

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                    <text>March 13, 1975

Joyce Small, M.D.

Street
Indianapolis, Indiana

1315 West 10
Deer Joyce,

pleased to enclose a copy of the final report of
our study of DH-52h (fenmetasole). we had spent a few months
defining the EEG effects of the substance and were convinced that
we had a good profile. To verify this classification. we suggested
a definitise cross-over study. we suggested this, a step that was
consistent with our original protocol, only to have the monsters

I

am

refuse to supply drug for additional studies. This
prepared, reluctantly, as a final stateeent.

summary was

I have had a chance to read a report by Mendelson on
the lack of alcohol blockade for this compound. I believe that his
study. which was poorly done and was not definitive, may have

tipped the scales against further studies of the drug.
On anapher matter, I have been called by Sol Goldberg
to ask whether I would be willing to act as an ad hoc site visitor
to an application from your laboratory. While I felt that I could
act reasonably impartially, I did indicate to him that we shared some
common

interests,

and

that he should ask your approval before

making

arrangements. I would, as you know, be pleased for an opportunity to
visit with you again.
conplete~~

My

it

best regards. Tell Iver the 33? program is almost
should get off my desk during the next few days.
Sincerely yours,

v4

«-

.g

2“
..-.

v.
1.

T

«www-

:
,..

&lt;-

V“.&gt;~

.

'.

-.W~"‘(Ws2-"WW-‘W‘

13;.-

.\

r
:
’.v";¢

,-.,..

,
'9

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>June 13, 1979
Joyce G. Small, M.D.
Larue D. Carter Memorial Hospital

Indianapolis, Indiana

h6202

Dear Joyce,
Thank you for the copies of the progress report on ECT and
the preprint on the lithium-BOT study. I found both interesting and
useful. If I understand the ECT-drug study, so far the ECT alone,
drug alone and combined treatments are equally effective with son:
advantage for the combined drug—ECT combination. I do hope that these
findings are examined further.
The lithium study is quite stimulating. The data are the.
basis for a prospective study witch needs to be done. I found three
citations that I missed (Hoenig &amp; Chaulk, Ray, and Remick)-- and I thank
you for bringing these to my attention. I believe that the cautions
you recommend (not to use ththium and ECT together) are good ones, and
I will adopt them, until further data are developed. (While the other
combination, lithium and haloperidol [or chlorpromazine] is controversial
as to its toxicity, as a therapeutic conservative, I still do not like to
use the two together, and so teach my students).
Many thanks. My regards to Iver and
help in teaching in the two courses in Chicago.

my

thanks for his

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>July 9.
Dr. Joyce 6. Small

Clinical Director of Researhh

1968

and

Laboratories
Larue 0. Carter Memorial Hospital

l3l5 Nest lOth St.
Indianapolis. Indiana

46207

Dear Joyce.
You

are correct.

changes in laboratory
and a cooy of the

My

associates

and I did measure the

test data during out drug study program,

report is enclosed.

Since completing that study we have become even more
concerned that any drug study should have concurrent laboratory

controls since established textbook figures are inaccurate

when

applied to an individual institution. We have designed a
laboratory form and set up programs for the analysis of the
data. Our first results were quite good, but we learned that
some corrections should be made in the form itself and we have
involved a private consulting firm in New York to revise our
data analysis and provide the results not only for ourselves
but for other institutions that may be interested. In the
event that Biodata Inc. can interest some of the pharmaceutical
concerns collecting data from various centers to send them the
data sheets then a central bank of laboratory results, hopefully
both for drug data and for placebo control will be available

for analysis.
A

be

copy of the MIP form is enclosed and the new one
you when it is available.

sent to
My

will

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>July 9, l968
Dr. Joyce G. Small

Clinical Director of Researhh

and

Laboratories
Larue D. Carter Memorial Hospital
l315 West lOth St.

Indianapolis, Indiana

46207

Dear Joyce,

are correct. My associates and I did measure the
changes in laboratory test data during out drug study program,
and a capy of the report is enclosed.
You

Since completing that study we have become even more
concerned that any drug study should have concurrent laboratory

controls since established textbook figures are inaccurate

when

applied to an individual institution. We have designed a
laboratory form and set up programs for the analysis of the
data. Our first results were quite good, but we learned that
some corrections should be made in the form itself and we have
involved a private consulting firm in New York to revise our
data analysis and provide the results not only for ourselves
but for other institutions that may be interested. In the
event that Biodata Inc. can interest some of the pharmaceutical
concerns collecting data from various centers to send them the
data sheets then a central bank of laboratory results, hopefully
both for drug data and for placebo control will be available

for analysis.

copy of the MIP form is enclosed and the new one
be sent to you when it is available.
A

My

will

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>‘

F“J-IvIK‘,"

«&lt;1

up

win—H

.wv-v'vptwu-r-n

v"

.r um“.

.

“.25' 151-- “in -~

w

—~.~~v-n7m-rw~-u

mum-.‘rm, . .wwvm-w~m~am

A~&gt;~r~m1~vwmma‘

-

urns—u

”m.wrvawr.l—F»mﬁ mumV‘WEV-wra-NIJVU1W

«an

napalm»: w. ...

-

«n-

Vex-m7

.w

v.

—n

September 20, 1958
Dr. Joyce 6. Small
13l5 Nest Tenth Street
Indianapolis. Indiana 46207
Dear Joyce.

It

was a pleasure discussing the electroshock program
I have reviewed six sets of records of unilateral

with you.

and find no bursts and only small degrees of background
slowing. These records are distinctly different for the
number of seizures from a similar group of bilateral cases.
ECT

When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

will be coming for the
to arrange to have you

New

York

City.

I would,

and I

of course,

anticipate

you

in early December, I would like
visit and go over some of our records
together. When we have had more experience, I would like to
arrange for one of my staff to visit you and to see the similarities
and differences. if any, in our treatment procedures.
ARNMD

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

Mszn

"z"- :-

»

-.- .,

,—

l'r

,:

w

'v

-

---

:-

.

~~

�</text>
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                    <text>September 20, 1968
Dr. Joyce G. Sma11

1315 West Tenth

Street

Indianapo1is, Indiana 46207

Dear Joyce.

It

was a p1easure discussing the e1ectroshock program
I have reviewed six sets of records of uniiaterai
ECT and find no bursts and oniy sma11 degrees of background

with you.

These records are

slowing.

distinctiy different for the

number of seizures from a simi1ar group of bi1atera1 cases.
When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

for the

New

York

City,

I would,

and I

of course,

anticipate

you

in early December, I wouid iike
to arrange to have you visit and go over some of our records
together. When we have had more experience, I wouid 1ike to
arrange for one of my staff to visit you and to see the simiiarities
and differences, if any, in our treatment procedures.

wi11 be coming

ARNMD

Sincereiy yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFrkD

�</text>
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                  <elementText elementTextId="102754">
                    <text>Novombor 28, 1968

Door Joyce,

plooocd to talk with you and I look forward to
Gracia
Sonata Bospito1- tho cite of our convulsive
your visit to
therapy study. on Thursday morning. I would oak that you moot
with my nooociatoo and discuss your :tudy, roviow our records and
stuéy and assist us in tho further develoonont of this program
by amounting thou: questions whioh already have no onowor.

I

won

The

on the main

hospital in at

float.

we

would

Street and our laboratory is
anticipate touting about 9:30 a.m.
620 East 76

I thall try to attond tho Eastotn EEG nesting and we
should bo ablo to make the plans-morn dofinito at that time. In the
event that I cannot coho, I can be rooohcd at 369-7900 or in
the ovoning at 516~666 5A44.
The

physician: involved are

physician and project leader; Dr.
’

and

recently amigrotod

Our

psychologist, Dr.

Jiri

from tho Prague

Dru. Riohntd Abrams. a roaident

Rouhicok. Visiting Profoooot

Psychiatric Institute;

and

Dr. Martins Green. and attending neurologist and long time ocuworkot.

I

on most

Rhea Dornbuoh

grateful for your assistance

to matting with you next weak.
My

will also attend.

Eavo a good

and look forward

flight

I

best regards to Ivor.
Sincerely yours,

Max

Fink, H.D.

�</text>
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                    <text>Roveeber 28, 1968
Dear Joyce,
was pleased to talk with you and I look forward to
your vieit to Gracie Squero Hospital—~ the site of our convulsive
therapy study. on Thursday morning. I would not that you meet
with my associates and discus: your etudy, review our records and
stuuy and easiet us in the further development of this program
by answering those questions which already have no answer.

I

hospital in at 620 East 76 Street and our laboratory is
floor. He would ontioipete meeting about 9:30 e.u.

The

on the main

I shall try to attend the Eastern EEG meeting and no
able to make the plane not. definite at that time. In the

ohould be
ovont that I cannot cone, 1 can be reached at 369~7900 or in
the evening at 516—466 saaa.

physician: involved are Dre. Richard Abrams, a reeideut
and
physician
project leader; Dr. 11:1 Rouhtcek, Visiting Professor
and recently emigrated from the Prague Psychiatric Institute; and
Dr. Martin; Green, and attending neurologist and long time cowworker.
Our psychologist, Dr. Rhee Dornbush will also attend.
The

on moot grateful for your eonietenoe and look forward
to meeting with you next weeke Have a good flight !

I

My

best regards to Ivor.
Sincerely yours,

�</text>
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                    <text>January 22, 1969
Dr. Joyce: Small

lame Carter Hospital

Indianapolis, Indian

DearJoyoe,

Indmddngﬂmghsom ofxrymtee, Ifindthat

Ihadprouﬁsedyoaendymapreprint Imgretthe
delay, but enclomd are two oral-mints demibing our
prawn: View of drug classification using EEG criteria.
One report is from the Armani Rewlw 05 Phamacotow

and another, a mom pomlar version, from a forthcomng,
book ”D1133 and the Brain.

__

IoouldmtmakeSmamsinJmmy,buthopethat

IcandosoattheCentmlEﬂSmtingainMardm. Is
possible for you to send me a mpy of the program and
any other data regarding motels?
My

it

.4.

,,-_..;.‘r,.

'M..;

‘

best regards.
Sincerely yams
ﬂax Fink, M.D.

_.

Professor of Psychiatry

”79¢

‘

�</text>
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                    <text>A.

.
,.

December 22, 1969

a
.A

y

~..,..-’.‘

rmvwnwun

Dr. Joyce Small

LaRue-Carter Hospital

Indianapolis, Indiana

nemmw;

W

—-vv'ww'"7

Dear Joyce,

Enclosed is a draft of the report read at the EAEEG. In
relating your observations to our own, I am aware of two problems.
Your data relates to the seizure and immediate post—seizure
activity; ours to 24 hours later. Whatever changes are induced
by repeated convulsions are more prominent in our sample than yours.
Assuming the accuracy of the observations, we can conclude either
an aspect of the immediate seizure state suppresses hemispheric
differences; or these are of such a clinical nature as to require
hours to emerge. I have been puzzled at the disinterest in MMECT,
and one possibility, from our experience, is that a chemical

aspect of the post seizure state is the therapeutic agent, and
this takes time to emerge, regardless of the number of seizures
at one time.
The September meeting was a

.A

Ma‘.‘

7'.

7;;

.:..w«r_-r(~o-,‘

an.

v-,~.~W:‘-na

success as

a meeting - good

discussion, interesting participants - but the group seemed too
heterogeneous to agree to meet again. The question was raised
of the advantages for such a group being formed, and when I
suggested that fund raising for travel, meeting rooms, guests,
etc. are feasible by a group and not an individual, there was
a unanimous authorization to form a "group". The World Congress
of Psychiatry in Mexico City was suggested as the meeting site.
I wrote to the secretary and have been told that an official
membership, as a section, is impossible; but an associated

meeting is possible.

If

I have

See you

in

the will,

I may

write again to

all

our friends.

Aspen.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>J

v

r

,

‘

'rvgle7grA"IWT~7¢‘—n"2«vwf'

‘3?
.
:vhw'w‘r

v—w

May

Dr. Joyce
1315

W.

Shall,

16, 1970

M.D.

Tenth Street

Indianapolis, Indiana

46207

Dear Joyce,

and

I

It

was nice spending some time together in son
much
enjoyed your presentation at the SBP.
very

Francisco,

I am writing to ask you send me a copy of the letters
to)
Joe Bird of'Sterling Winthrop regarding cyclazocine.
from.(and
am
distressed
that they are discouraging testing of’this interesting
I
compound. I don't think I can do anything directly, but I do talk to
JOe Bird occasionally and I may be able to have him review his decision,
if I know the basis he gives.
at 58?.

Many

thanks, and

my

congratulations to Iver on his election
—

Sincerely yours,
Max

Fink,

M.D.

Professor of.Psychiatry

mf/

�</text>
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                    <text>February 19, 1971
Dr. Joyce Small

Carter Hospital
Indianapolis, Indiana

LaRue

,u
..

NLJq-yInLL-I

L"¢I~{"

"Jl‘

«aw-:12.

-,:r
\r
.1

“ygmﬁ'ﬂ”

~'E‘1-".G"I‘_'!"‘7"

‘

‘qua-uey

an?!

Dear Joyce,

Sbminars in Psychiatry, a new quarterly publication edited
Greenblatt and Ernest Hartmann, has suggested that the
Milton
by
be devoted to Recent Progress in
first issue of 1972 (February)
am
I
pleased
you have accepted the invitation
Convulsive Therapy.
Results" Indoklon (vs. KCT)".
"Clinical
on
the
report
to contribute

notes in the outline are suggestions, and you are free to expand
on the topic as you wish.
The volume is usually 120-160 typeset pages, equivalent to
200—300 typescript pages. Your report should range from 25 to 30
double spaced pages (including citations).

The

To meet

the publishers deadline, can you

by the end of June?

make a

draft available

I.
w
-,

y
a;

'Kauc'qa

-'
o;

“L!“

.

a policy of the Shminars to rewissue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

It is

"jﬁ"?1"!‘l'_

"
r?

I

hope you can

join us.
Sincerely yours,

u‘f'A‘szﬂ

:'
.

‘-

'rﬁawumz'

Fink, ELI).
Professor of Psychiatry

Max
FCWJ.‘

Mime-:5}.

"Ref:

rmmmlwaw'

in?"

7W}
laws

MF:kt

�</text>
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                    <text>Il

“mm_ﬂ_‘

WWW—w...

~W

November 9, l9?!

.w—u—v—"n—

v-W.w—w

Drs. Joyce &amp; Ivar Small
lndlana Unlverslly School of Medlclne
lndlanapolls, lndlana

v

VWW

«W

-—

—-

Dear Joyce and

lver,

varlous reporfs for +he ECT volume ln Seminars
In Psychiatry are now a+ fhe publlsher, and fhey have a planned Issue
am encloslng the llsf of authors, and
dale of February, l97l.
ldenflflcaflon/addresses. lf correcf, please do nolhlng. If lncorrecf,
please wrlfe me.
The

I

fhe Seminars.

You

should recelve The galleys within

6

You

wlll also recelve

subscrlpllon To

a complemanfary

weeks.

fhanks for your flne confrlbuflon. l fhlnk the
Issue wlll be a useful one, and your report ls most valuable.
My personal thanks for The fine cooperaflon.
Many

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry

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                    <text>January 30th, 1973
Joyce G. Small, Md)...
Larun D. Cartar Mamorial Hospital,

10th Street;
Indianapolis. Indiana
3.315 V.

hSEOT.

Dear Joyce,

Eneloaed is a manorandum prcpared by my associate.
Dr. Khan Dornbush, which describas the proceﬂnres for
unwary teating H! found useful in our EGT and cannabis
etudiea. whim paradigm may ha ayylicﬁble to the study
of OI~63 and aeizurea. It the task is too aimple or toe
difiicult for your population. the rung: of tasks allows
a ready modification, by incraasing complexity or
simplification, to accommodate your lawndiute needs.
The articles on Oluéa Appear in volume 32, Progress
in Brain Research, edited by de ﬂied anﬂ waidnen and
carries the title “Pituitary. Adrenals and the Brain".

It was

we can
GB~9h

good to talk to you at langth, and have
find the occasion soon to diseuas QI~63 and

further.

MW

beat to Ivan.
Sincerely ycura,

Fink, M.D.
Frafeaaor of Psychiatry

NR1

MF/iJ

ﬁnes.

"'?’f:?-YV1‘=W'"L“"

M-vvq:n~rw,a

.v

a

�</text>
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                    <text>V‘W-u—Im.

‘21.:

.wmvmx.

~

y

rswrwvwr a“;

-

.

imm 1W

,

.uuo-m mar-u
7

,

-

*‘--'rv&gt;'v-vr.

"..mm.jnlm»any. my“. «yen-V

-V1u:wg-1m~7‘g' A...

.

. In”
.
.rrnrwmr’l-

.

guy-1‘5.

r

.v.»

we.“5“.7,“.
.

December 17. 1973
Dr. Alex
Old Post
Rye, New
Dear Dr.

Carlen
Road

York

Carlen,

.—

lb."

M

Wm,

r—w—w-m

.

.1..."

-mmwvmmw—

A,

e,

.
-

'Lefkowits

I

pleased to recommend the elevation of Dr. Henry
in the American Psychiatric Association.
fellowship
to
am

Dr. Lefkowits was a resident in psychiatry at Hillside
Hospital in l957~l959, and then remained at the hospital for an
additional three years as an attending psychiatrist. During that
time he was active both in the treatment of patients and the train»

inig of residents.
of my division.

He

also participated in the research programs

Since leaving Hillside, he has been in active practice
in Uestchester. From time to time, I have heard of his work; most
recently, in his role as consulting psychiatrist to the elderly
at the Guild for the Blind he has worked actively with my mother
who

tas a social worker at that institution.

In these relationships, I have always found Dr. Lefkowits
sincere, dependable, and considerate. He is a fine physician. In his
recent interestiin community activities, I believe he will make the
contribution which we would expect of Fellows of the A.P.A. I
endorse his promotion and election without reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Fellow, APA, '51
Former, President, Nassau

NP

Society

~

.

—

�</text>
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                    <text>7483—06288
6

Mr.

Charles Schultz

Burcuu of

narcotics and Dangerous
v.3. Departunn: of Justice
555 West 57th Street

February 1976

Drugs

ﬂaw York. New York 10019

Dear Mr. Schultz:

Enclaacd is a copy of my roapnnno to thc
from the Drug Enforcenant Adainistrntlon.

letter of

Rovenbur 12

In chacktng the paper: available to me frém A3008, I have no
rnacon to changa my opinion submitccd on thnt data.

sinearoly years,
Pink, M.D.
Professor of Psychiatry

Max

MF/eis

Encl.

5‘
-~.

.swn

w,

r‘g-n

”Ir

wm

-,—

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                    <text>June 17, l97h
John Stern, M. D.
Behavior Research Laboratory
Department of Psychology

Whehington University
1h20 Gretten Street

St. Louis, Missouri

6310h

Dear John:

I thank you for sending me the reprints which have kept
informed of your progress. Lest year I moved from the New York
Medical College to the Health Sciences Center, State university of
New York at Stony Brook, New York. A good friend of yours, Bernard
Tursky, is in the next building. We have had many pleasant dis—
me

cussions.

I look forward to being in St. Louis at the time of the
Neuroscience meetings in October, and perhaps we will have a chance
to discuss the many changes that have occurred in our science and
in Missouri since I left.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed

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                    <text>July

23 , 1963

Dr. moms L. K. Suva].

Director, Office of manta 8 Research Contracts
Natiml Aermmﬁm and Space Ministmtim
Washingtm 25. n. c.

warm". Smll:
fmm

‘I’nia

latter-

follm

the

mummt in the A183 Bulletin 0f October

the analysis of EEG sigma; modifiers of hallucinogenic
W:Mmﬁmmmchbwmthobiologimmm
in
the affects of axpar'imsntal empomds on the

1962.

of

I amwritingﬂmis latteraf inquiry mmdingmaenmhswpwt
NASA of studies mu being developed at this
team mar.

mum,
«We»
illusory swim in perceptual iaqlatim Wm.

Fwanunborofyummlnwbeanstudyingvarimmysof
dumps in brain wave potentials induced by mychiatric
Tm initial todmiqms mm hen-1d analysis fonmed by
mama.
fmqmmy analysis using mmant filters. In the past six momma
we have devolomd a program for amputat- mlysis of EEG signals,
using an 1314 1620-1719 system. me first mm is now manning
wacimand
aﬂprovidesmwithanofﬂixmspeetzmofﬁmﬁﬁe
agtituﬂes. The
able tim
pcmits variable baselines,
mountains

patina

W

and variable frequemy hauls.

mmmmmmmingantidmlimrgichallmim

toirxiuoa psydwticstatesindogmdm. Wmeminga
variety of compounds for their bloddng activity of this paydwmmimtic effect. The first
of a series that is effectim in

Wad

banammmddomisnmboingpmpumdfordimctolinioal trial.

�W.

m

In K.

W

Jay

“2"

23. 1963

'mathirﬁsmdymmismiﬁngﬁnmletimofan
1115.: will ha
@13th by the and of October.
Itisotmplmtoasmaavarietyofpaydw -c mm
mﬂmﬂmmmmdsfamdtobesmssful
Immdcholimrﬁc
in mdifying
sensatims
sum-n few their
Relation dumber.

ability

illusory

in an isolation dumber.

cumming

measure of Gangs in behavior.
amtInmmnmrme,EEGandysosprwideam

The masonmi Institute of Psychiatry is a research mm:mated by the Division of Mantal magma of the: State of Nissan-1.
The staff is made up offal-time investigators. The Institute has

its facilities
as
laboratory
tists an

Sityo

a

space. 5
appointed
V

unit, 20,000 mm feet of
unit and medical libmxy.
etc. Sciento the staff of Washingtm Uniwr-

150 bed Inseam}:

mm
may

Ifanyoftmsepmvmofinumttoﬁwbimcimsthese

promofNASA. I

with a

shwldapmcigmmwpomitytodim

topmontatiw.

V

Sincemly yours ,

Mm:

m,

H. D...

and

Dimctor

Research meosaor,
Washington Lhivemity School of

'Mthr

Maine

‘

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                    <text>July 19, 1968
Dr. Alan E. Smith
Duputy Director

Division of Anti~infectiv¢ Drugs
Office of Now Drugs
Bureau of Medicine
Food and Drug Administration
ﬂushington, D.C. 20204
Dear Dr. Smith:
The

RE:

IND 2822

studies of cycloaarina, with or without

Dilnntin
undertaken at the University of Missouri were couyleted
in
the

winter of 1965. Unfortunately, I moved from
in May of 1966 and have not had an opportunity to Missouri
summarize
the information. I have contacted one of my associates
and asked that the data be summorizod.
The

study was discontinued in the winter of

1965 and

each of the investigators were notified. The unused
supplies
of cyclosorine were diocarded.in Missouri and are
no longer
available.

Sincoroly yours,
Max Fink, M.D.
Professor of Psychiatry

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                    <text>NEW YORK MEDICAL COLLEGE

NEW‘

FLOWER AND FIFTH AVENUE HOSPITALS

mmommum
CORRESPONDE‘

FIVE EAST IOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

July 19,

1968

Dr. Alan E. Smith
Deputy Director

Division of Anti-infective Drugs
Office of New.Drugs
Bureau of Medicine

Food and Drug

Administration

Washington, D.C. 20204
Dear Dr. Smith:

RE:

IND

2822

The studies Of cycloserine, with or without Dilantin
undertaken at the University of Missouri were completed in
the winter of 1965. Unfortunately, I moved from Missouri
in May Of 1966 and have not had an opportunity to summarize
the infOrmation. I have contacted one of my associates
and asked that the data be summarized.

study was discontinued in the winter Of 1965 and
each
the investigators were notified. The unused supplies
Of cycloserine were discarded in Missouri and are no longer
The
Of

available.

Sincerely yours,

W

Fink,
Professor

Max

Mszp

ﬂimwf‘é’“
M.D.
Of

Psychiatry

3

”Ct:

�</text>
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                    <text>August 17, 1971
Dr. David Smith, M.D.
321 Crestmont Drive

San Francisco,

California

Dear Dr. Smith,
While I would have no objection to the republication
of my article, "A Rational Therapy of Opiate Dependence: Narcotic
'ﬂntagonists”, the original publication is set for the proceedings
of the international symposium held in Ann Arbor in October. I am
enclosing a copy of that report, and suggest that you write to the
editor of those proceedings, Dr. Chris Zafofenetis at the University
of Michigan, for his approval.
Should he permit, I would ask

necessary footnote that the

etc.

that

you provide the

article is republished, with permission,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>Mazda 25, 1966

Ginny R. Smith
Q‘liﬂf . Grimm Hanammant Brmch
Division of haunt-ch 6mm:

Mr.

ELEM.

Beti'nsda, Maryland

mar

Mr.

2001:»

Sndth:

With regard to your letter of Him}: 11. 1966, requesting
infomtim cmonming tho fiml report of cupmdimms in
Grant momoonuswa and ~0381, plam be notified that the
final mporthuboenfilodmdamvisodexpendnd grant
nutmdution adjustmt notice received. A copy of the
latter is enclosed. In that authorization, the sum of $150.98

to be

withdrawn, and the Pomdatim has almady

to the
wt
I trust that this will

was requested

mtmd this

D.H.E.W.

earlier this

month.

clarify yaw hoards.
Sincerely yours.

Hszmh

Encloowe

m Fink. Md).
Director

Win

�</text>
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                    <text>November 1, 1971

nun

wu~

Vw‘....a....-.~.m—n

5.....-"

Dr. Jean Paul Smith

Division of Narcotics &amp; Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland

mvvuvw'fv-

Dear Dr. Smith,
aw?

I am enclosing preprints of a number of our reports
regarding naloxone and cyclazocine, and the latest report on the
comparison of methadone and Z-alpha-acetylmethadol. The latter
report is being submitted to the JANA.

‘m

A

«Izslv'll'mn‘

Separately, Dr. Alfred Freedman has submitted a grant
application entitled Novel Narcotic Antagonists in Mhn for the
consideration of the appropriate committees of NINE. Included
that proposal is a sum of money for the subcontract to do the in
animal toxicity studies necessary for an IND for the antagonist,
MFSOSO. Any assistance you can give to that
application will
allow that agudy to progress rapidly.
Again, I regret missing the meeting on narcotic antagonists,
trust that we will be able to contribute our resources to this
interesting program.

and

Sincerely yours,
Max

gm.

;
‘77

~1‘lw‘v‘ww—

mf/
.

,‘ﬁkww,,“w.-wnr—.V

r6"

vaI-

2w:

wwwrw‘

“trap-535w.

.
r':

-.

Fink, M.D.

Professor of Psychiatry

4

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                    <text>March 31, 1972

Jean Paul Smith, Ph.D.

Division Narcotic

&amp;

Drug Abuse

ﬁational Institute Mental
Health

Fishers Lane
Rockville, Maryland 20852
5600

Dear Jean:

all our reprints relating to diprenophlina
enclosed.
capies are
We have sent 10 ﬁt::;?ﬁ*5050 to ﬁr. Woodard for animal
toxicology studies.
I otzﬁzrlhe
will be helpful.
He

(ﬁvSOSO);

have collated

reprints

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF:1g
Enc.

�</text>
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                    <text>Jun. 7,

Jean Paul Smith and Alisa Runs

To:

1972

,

national Institute of Hental gtzicn

5600 Fishers Lane
Rockvilla, Maryland 20852
ﬂax Fink, ﬁ.D.

PROM;

SUBJEDv4

4

Drug Use:

harcotic Addiction

Program

During 1972-73, the SUNY~Stony Broot Drug Abusa ptogram.will

examine tha usefulness of cyclazocinc in their treatment of opiate
to methadone and leVumethadyl. In this
dependence, and compare
study. diacetylmorphine will be used in “heroin h lleuges” to mea—
sure tha degrea-of blockade (to éefine adequacy, duration) and to
demonstrate the potency of these substances as a 3tep in the decon*

it

.

ditianing process.

(1) nglggggigg. After detoxification, patianta will be
1ndt¢tod to h—6 mg. cyclazocine in 4~6 days. As an antagonist to
the agent-tic features of cyclaxocine, naloxone hydrochloride (0:31)
600 mg. q3h; prr.n. will be availabln for the 4»6 days of the in—

duction period.

�Jean Paul Smith

8

Allan

2

June 7, 1972

Romany

Following the ptovailing high dose roginono,
on will induct patients in 20—40 days to 100 mg. oral daily. (Should
it peeve hooful, we may adfpt a low dose (50 mg/dly] schedule).
(2)

Mothodono.

0

Induction to 80 n3. thrac
in plannod.vith tho induction poriod of 6 weeks.
(3)

v. will

Levomothadz .

tin“

a week

(b) Heroin Chgllongo . Following our doocribod nethoda,
use intravonouo heroin (20,30 ng/lcc onlino/luiinutc) when

subjects at. drug-fro. (to dotino heroin response) and whom induction
to cyclnxocinc, levooethadyl, or nothodoln 13 achiavod, to define
efficacy and duration of blockade, and b» {novide a basis for do—
conditioning.

mueaﬁﬁeﬁem
Based on 50 patients receiving cyclazociné, and 45 each on
methadone and levomethadyl.

6: 90

liters,

Cyclazocine:

36

Naloxonoﬁ

240 grams (800

Methadone:

500 grams (powder)

Levomethadyl:

150 grams (powder)

Heroin;

10

grams

grams

tablets,

(powder)

2 mg/Scc)
300 mg each)

/

�Joan Paul Smith

&amp;

3 _

Allen Ramsay

Juno 7. 1972

CITAIIOHS

Haloxonn Paloata: A Long~Act1n3 Opiate Antlgoniut, (submitted for
publication). (R. Lavina, A. 23kt. I, A. Frudlun).

Luvoanthadyl 1n Haintenanco Trcatncut of Opiatc Dopendcnna.
(A. Zaka, f, A. Froodnnn).
Duration of Hathadon. Induced Crocc~Toleranca to attain.
Addict. 66: zoswzos. (A. 2m, 9. A. M. Kama-nu).

84.

J.A.%.A.,

'“

I

J.

Cyclaxocina Therapy of Opiate Uepcndcnca w &amp; Progress Report.
Compachenb. Psych£a£., 12: 491‘502, (R. Rasnick, 3, and A. M. Freedman).
A

Rational Therapy of Opiate Dependence:

Amen.
and R.

J.

NuAéLug, 71:

Maniac) .

1359-1363.

Harcotic Antagonists.

(with A. H. Frocdmsn, A. inks,

Naloxone Traatment of Opiate Dependence.
(A. Zaks, T. Jonas, A. ﬂ. Fraedmnn) 5).

J.A.M.A., 215:

2108*2110.

Cyclarocins Typology in Opiate Dependence. Amen. J. 7&amp;ychiat.,
1256-1260. (B. ﬁesnick, # and A. H. Freedman).

126:

Intravenous Qiacetylmorphina (Heroin) in Studies of Opiate Dependauco.
Ned». Syét. Supp£., 33: 89~92, 1969. (A. Zaka, A. Brunet, 5.

die.

A. Freedman).

aaloxone in heroin Depcndence, C££n. Phanm. Thenap., 9: 568~577.
(with A. Zaks, R. Sharoff, A. Mora, A. Brunet, S. Levi: and A. H.
Freedman).

Clintcal Studies of Cyclazocine in Narcot1c Addiction. AmeA. J.
P3gchiat., 124: 1499~1504. (A. a. Frcedman, #. ﬁ. Sharoff, and
A. Zikl).

V/

�</text>
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:t'

'a:g.-¢~w_

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11 . 1977

Jeanne Smith, M.D.
210 East 73 street
Nev York

City 10021

Dear Dr. Smith.

During the past nine years, I have studied the effects of
cannabis in long-term hashish users in Athens. Among the studies
vere detailed EEG examinations of men who used hashish for a mean
period of 25 years. smoking on the average the equivalent of 260 mg
TBC-dajisaleﬂle did not carry out spinal fluid examinations.

Var‘ﬁ.’

W“

v. .r_.r..w——.—.;mi,w~,,,..v

damage

tests.

In these studies, we failed to find evidence of brain
after prolonged use, either in the EEG, echo—EEG, psychological
and neurological examination.

Similar studies sore done in long term users in Jamaica. The
findings are published by Rubin and Comitss, GAEJA in JAMAICA, Mouton
ress, Paris, 1976. Our findings are in press and will appear this

month (Raven Press. New York, HASHIBH.
Stefanie, Dornhush and Fink. Editors).

A STUDY OF LONG—TERM

USE,

it unlikely that the
spinal fluid protein determinationssare related
to two years of marihuana smoking. I would suggest that your son have
a thorough neurological assessment and if the findings ere incon—
clusive, that other causes for the illness be sought in hormonal

abnormal

From

EEG

these experiences, I think

and high

dysfunction.

I trust those

comments

are helpful.
Sincerely yours,
Fink,
Director

Mex

M.D.

,,,.

... any“...

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