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                    <text>October 22,

19634

Dr. Fini Sehuleinger
Chief Huysioim, Psychiatric Clinic

Kamehoepitalet

,

Copenhagen K. , Dermmk

DearFini:

Itwasegmttpleasuretohearfmnyou, andIam

pleased to write you on the second anniversary of the estab—
lishment of our Institute. As you described the problem in
establishing om study, you can well imagine the problem of
establishing many. It has been an interesting time and during

‘

tmpest fwmnmlfindmatlhedefwowesimsmml

could return to the research world. I am very soda interested
in your study, for if you om separate the congenital problems
from enviromentel in schizopluenie you will be doing much for
our field. One of our studies is an attempt to measure neurophysiologio differences in thwe patients who are still in the
institution and those who leave after relatively short periods
of tmetrmnt. Our enphasis, as you can imagine, is to determine

differences in msponsivity in the subjects to external agents.
and
these differences in terms of EEG charges, tolerance

mm

and some biochemical.

masons.
I an pleased also to try to answer yew question
about BCI‘. This problem is an old one and when I did sous studies
in commisive thempy looked seriwsly at the differences between
direct cutout md alternating ourment instnrnents. You may re»
cell that early in the 1950's there was a great deal of interest
met subomwlsive or direct current treetnent might have fewer
side effects than the conventional alternating current methods.
As a consequence, during one of our studies we compmd the clinical,
electrmphic, and psychological test charges in a group of patients
randomly assimed to suboonvulsive, threshold omvulsive using an
alternating cutout instmment, e convulsive nethod using direct
.

.

~

current (parethreshold—«direotionel on the figure) and suprathreshold—alternating current instrument. The results
ized in the short report in the diseases of the Nervous System,
and in the figure which I am pleased to enclose. Depending on your

m SW
.2:

�October 22,

52..

196|+

Dr. Fini Schulsinger

theoretical model for the node of action of convulsive
therapy, you will either believe that high degree slow
wave activity in the electroencephalog‘mn is an important
and variable index in the therapeutic response or you will
believe that it is a side effect with mgative cometations.
will
If you believe the former, as I do, then the figureachieved
slow
wave
damastrate that high deﬁes
activity is
with suprethreshold alternating oment instrumnt earlier
and smtained better during a three times a week treatment
.

period than with any other method. The differences between
the three convulsive methods and subconvmsive is very significmt. The differenms between the convulsive treaumnt
methods is slight. When Martin Green and I did this study,
we used to say that therapists in private practice using
unidirectimal mdﬁms world on the average make $25~50
mm per- patient than those using the alternating cument

Mine! Bythisweneantthattheywouldtendtoseevarious
than those patients
five days

clinical results three to
later
treated by supmthreslmld alternating current nethods. So,
inanswertoyowquestim, ifIhadtobuyamaclﬁnehem
I would insist on an alternating current instrument. Plowever,
I had a midirectional machine available at no cost, I
if
muld wider the difference so trivial that I would comtinue to use that machine.
What

ever happened to your comtional Per

is

Usden?

are rapidly approaching our winter seasm. Temis is still my major pre-occupation,
and when I do not travel for the National Institute of Health
or for the Institute, I find the days in St. Louis pleasant
and relaxing. I missed visiting you this sumer, and I regret
that my assodate did not visit you became I feel that he
could have learned much. However, there will be another- summer
The summer

and

over here and

we

I will look forward to visiting with

oppor'tmiity.
My

'

enes.

at 115: earliest

best regards to your family and to Dr. Katy.
.

Inf/ls

you

Sincerely yours ,
1%

PM, NJ).

Director

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                <text>1964 </text>
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                    <text>November 27, 1961;
Dr. I-‘irﬁ. Schulsinger

Chief Physician, Psychiatric Clinic
Karmmehospitalet
Copenhagen K. , Denmark

DearPini:
Yesterday,

I

had the nest pleasant experience,
to St. Louis and called me before

for
his talk at St. Louis University. It was a great pleasure to
talk to him and even more so, to attend his lecture last
evening. He presented your study in considerable detail. His
report was received well by the large audience of students.
The background for the program, the decision to do such a study
in mpmmagen, the selection of psychophysiological variables ,
Dr. Sarnoff Mednick came

the control group and many other aspects were described well and
gave us the feeling of a well designed and well thought-out
study.

My

reactim were two-fold. I was impressed by
looked forward to the findings. I am sanewhat

own

the program and

dubious that the psychophysiological .measwres selected are the
best measures of brain ftmctim. The theory that Dr. Mednick
projected and my own understanding of the possible genetic
theories of schizophrenia lead me to think that alternately you
are assessing a reasure of brain function, and if so, GRS,
heart rate md rﬁ‘spiratory rate are but distant and possibly
unsatisfactory reflections of brain function. After the meeting
I asked why you had not included some other treasures such as

or caref tests of mermry function.
being considered and will
that these
probably be included in the next phase. If there is anything
that I can do to help you in the selection of variables, I
would be pleased to do so.
The other feeling. that Dr. Merrick projected was one
of great therapeutic nihilism. At the beginning of his talk,
often in the middle and accentuated markedly at the end were
statements reflecting his feelings that there is no treatment
for the severe mentally ill and that the only hope is in pre—
vention. Perhaps he is right. However, the audience was one
of many young students and while I hope that he is right and
perceptual tasks,

EEG,

Dr. Medniok answered

'

�Dr.

Fini Schulsinger

that these and many others will

November 27, 1964

go

into a research career to
still seems to be a need

find the causes of the illness, there

andanimportantmetocareforthesenentﬂy illandto

try, as best as

we cm, to ameliorate their symptom. Our
studies in the treatment of chronic schizophrenics
have
given me a feeling of limited optimism that we can help some
of them with the treatxmts available to us today.
own

lhe iupression that he left was so strong, that a
of the students did ask about the possibilities
of
your populatim at the present time. Dr. Mednick
laugned md said that the present mup, while they anticipated
wwld include '40 schizoxmmnics, would
not be taupered with
but

W

nmnber

that you were planning that as soon as the criteria were
clear, that you would look for other young people
and
various
treatnsnt measures. Dr. Mechick indicated that he hadtry
idea
no
which measures should be tried but did speak som‘ewhat
ally of a oanbination of drug and learning therapies . optimisticEqually interesting was his description of mother
genetic study that you are mdertaldng with Dr. Ketcy. This may
do much to clarify the genetic and the social factors in early
schizophrenia. Good ludc on bdth your studies.

in

Dr. Mednick indicated that he will probably be back
Copenhagen in the late spring, and I do hope that your

project will permit you to come to this country soon.
My best regards to your family and my best wishes
for the new year.
Sincerely yours ,
Max

Fink,

Director

M.D.

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                    <text>January 25,

196-5

Dr. Fini Schulsinger

Chief

Miami

WW?
Dem

Paydxia‘mic Clinic:
~

Bowﬁni:

Imdangxmdwimﬂnmmtofymmtdp

W

tothelmimdsmm,mditgimmpleammtoinvim
before
of

13:4:th

mu to present a
Paydziutxy of Washingtm uximraity. The staff of that
t are partiwlarly interested in the classifica»

timofmmntallyinmxithegmoticaspemofthe

psychoses.

Itlﬁnktiwwmldbainmmsmdinming

mmsekadmofymmmlaﬁms,ﬂnclassifiuatimpmchms,andanycmoftmpmmmmwﬁdm
ywmyhomyingmtin'mmumutiwstmy.
mm.mm1dcwasm,mmsmtedhismportto
thumpmmtofl’symoloyofsmmistmimity,

“Mmfwwulf,Ismmoﬁurwberoftm
Fwﬂmismsm,

Wmmaffatﬁmm.
pmmtatim could overlap his witrm fear of

your

duplionﬁm.

Ihavelodwdatymmscmdulemdseeﬁutyw

mplumingtoleaw Datxcitmf‘ebnmy
In
spend Pebnmy 25th

in Chicago.

2ut11,and

that intentia'al?

IfIzudtrnmtofthaitimrley,yuuwill
Muﬂvingmﬁnmirgofhbmﬁthmdpmg
Ishallmuge
mmmmmgxtforﬂw‘fmk.
formtﬂkﬁiday mum, Fem-y 26th. altrmgh

Waﬁmatﬂﬂﬂmbemmthm
Wowillmpeytluomesyounqmst.

Ifymcmmmgotomtoﬁt.muisoarlier
.mtmzsm,1maldliketohmymmtmoftm
staffstmymmdmwmge‘bospendmowﬁngwith
us. Wannabepmdtohmyousteyatmm
to St. Lads.

WWymmviait

�milelanwiningtoshamymmtimwiﬂxﬁn

www.myusociatwmdlmuldbeplemdtochat

withyouaboutymmmbutymﬁm,asmmcuwying
out an cvaluatim of trifluperido , and have an active
managemuatimwﬁt.
Have

a

good

trip.
Sincerely yams,
D.
m
M,
Professor of Psychiatry
No

Pﬁzjm

�</text>
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                    <text>February 3, 1935

m Finis

Ihemermngecforycetcmtwithttneteffc!
«t
tau
Wlofhedicimmﬁiday,

MWQIWWWWIW
FWZﬁﬁxetmm.

'

They

willhmelmﬁmmtm:sndlwillmeemaet
ymzedeftwymrtam.»

Ihewtcldmmtymmmpsychiammin-

mery
heintereetedih
Wealmntemmﬂd
wudescribeti'zeeelectimo!
steyoi'thehdsidcmﬂKatymjecte.
interestedin

mcrimiemdthmblm,
rmy. mtymhewhsdinfulfillmthecriteria
tsfsrhcth

Ihmfmmmwhmmwmiologicel
dete,Ithinkycu
Whempuedtcmtmdf

it mimmim.rmm.thetttﬁewimoeie
ewwiticalm. ImmthattMywilleskqmstime

Mmmﬁmdoldw.

Ilsakfmnﬂtomvisitaadmmma

rewardingtrip.

Sincerely yaw-e.

Fink. ELI}.
M
Professor of

Psychiatry

mule

6.0.! Er.

3W

Katy

A

�</text>
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                    <text>April

19‘, 1955

Dr. Fini Sohulsinger
Grief mysioim
Psychiatric Clinic

Kunmlwspitalet

W

Wagon K.
DearPini:

InymmlmtletteryouindioatedﬁutyouhaddismsedwithSeymm

htyﬁnpoasibintyofmmmbeingmdeinymmstudyofohildrenof
Mmindioatsdthatheﬁrwghtﬂaismgxtbean

MWQW.

miwadditimtoyumpmgrmImpuzzlsdsinoaImmderm
such a collaboration.
that he would
ispmsim

support

Ihadthaoppornmity lastmktodismsmﬂrerpmblemwithkukety
mmmwpwhmtytoaakhinahwthismmmdatim
Heindioated,

asImoheliam,thatmstudyisamiqueopportmitytoobtainpmspeotivedatawhimmsuppatormtutesmofﬁnhypoﬁmsesregamingﬂm
etioloyofsohiaoﬁmda. Preoisalybeoauseofitsmiqmnatme,youhave
Wtforpmdiotorsmridruyhelpym. Iindioatedtohimmdlbelieve

ywareuamofﬂnlitemumthatinjmyinhminfmotimmyooourearly
mdnayhemisportmtdeteminsrxtintmsohizoplueniopmoess. Ifsudma
serit,theoolleotimofEI-Erecordsifdoneoaxefully,
Wishsssny
mldpmridsamiqmandspeoialopportmitymdmyeffortﬂutis
nasaublsshwldbenadetooolleotsmhdata IbelievettmtDnKety

mldoonwhthisophnim,modifyingitmlymarashewmldwantto

momsinumstxﬂyismylaxge,goingtothe?edsmleomm~

beassmdﬁratyoutudareliabhomsultmtmoseuperimoeineleotrowas

sufficient to

make

his malyses credible.

Seomdly,

mtforadﬁtimulsupportforalammtofﬁmequimntmaynotbe
warmted,minthisopinimeouldm.
Iwouldliketosuggesttlmtifﬁmmoomingofﬁmsimalsombe

inolrmdaspartofymmsmdy,itwwldhaveomsiderablemeritmgam1ess
ofwhetherﬁiefindingsdoordonotshwdiffemsinthsstudymd
omtrcl pepulstions. Insofar as I have been interested in this subject for

smyears,lm1dbeploasedtomuabontewiﬂrym. Iwouldalsoassure
ymﬂmatifﬁreremarewellpmpared,lwillmlietthesupportof
stainaxevieuofﬁre
othersmiwels our
-.
zeoorthbefoaetmdataisretmdtoymforﬂmomeelatimsthatwin
—

havetobedonewithyourolinioalfindings

ﬁght he carried out with very expensive equipment such
tapemoorderssothatweomdothequmtitative
analysis here, I believe a very modest pmmwwld suffice. I believe you
alreadyhaveanOfmerdymg‘aph
While the shady

”www.md

'

�Winger

Dr.

A

«2-

April 19,

1’me
ifymwim.mdmtmpapermcordsbommminimm.

1955

Whitwmmbeadvisabhtohmfwmpmmuﬂem,lbelim

that Mmuldbe sufficicnt
Andn'irmeffortwwldbeto
WEEG aim-ml: in yourchildmn under set'cmditicns which I can detail
Analysescan

bedanviauallyandﬂmmavaﬁetyofhmdqumtifyﬁxgmﬁwdawhim

mavaildalemdmiehcmdoaawllasclomic

devises alﬁxwghwch

mmalowly.
If. in additim, you wished to avail yourself of the latest electrmic
gadgetry, that a sun m tape rump would be mquired. 'Ihe Mom
medals can be purchased for rims mdur QMOOOJO, and I believe that: if
this am is too
ticn to your budget. it should be possible to
an
obtain

wt
imam.
sumammrohmmﬂm

Wmemtactwimm'.lhm1dcwasﬁntamthathegmin8t.Louis

com mums ago.

who have

1:083:1an
It is writethem

greater experience

that he 1mm elwhmnaephalogmphem
and whose interest in this pmject
um
m

wouldbemater. Inthatemnt,1wmldurgeyoutoenliatﬂmirsupport

fwmntuybemiwortmtadditimtoymmpmgrm.

Ifymwiah.l~mover,

tomliatthowpoztof'dﬁahbomtmyImassmyouthatmwﬂldo
amthingpmsibhtopmvizhﬂwmlysuaitherofﬂmtapeorofﬂm

Ithimcyoushould
Wmnmuddiﬁmumttompmw.
anticipate mly those mats inherent in the initial equipmt, md the costs

ofgmdingimludingtmuofpapenmtictapemdthemdmdm
an ass.

Imtakingtlmlibertyofsondmgacubmofthiohttertonr.xe

bemolboliowﬂntﬂﬁspmjwtismimmmtmomdbwamIthm,
ﬂuthahasbemnguidaﬁmmthommofthegmtspmm.
Lastmkllmtinwmgismﬁmsforthelntmﬁmalmmﬁngs
inVimmudngthoﬂmtmdcofSeptamr. IMpetlntIcmmmgeto
visityouaiﬂurmﬂwwayteﬂmormmymtuminﬂwthirdweekin
Septomor.

Iwinwriutoyouagaininafwweekamcemytxipscmwe

ismdoclur. Wbutmgardstommm.

Sincemly yours,
D.
Fink,
m
Professor of Psydmiatry
M.

Mszp
CC:

Dr. Seymour Kety

�</text>
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                    <text>Nay 26, 1970

Dr. Fini Schulsinger

medical Director

Konmunhospitalitet

Copenhagen, Denmark

Dear

Fini,

It

we have written, but I
friend, Dr. William Karliner,
summer is is interested in visiting
some of the facilities . Dr. Karliner is an expert in convulsive
therapy and has an extensive clinical practice with chronic

has been some years since

writing at the request of
who is visiting Denmark this
am

a close

schizophrenics and the acute depressive psychoses. Would it he
possible for him to visit your facility and meet with anpropriate
members of your staff ? He plans to be in Copenhagen about August
(Wm. Karliner,
1749 Grand Concourse, Bronx, ﬁuw York 10453)

7 ?

I keep hearing good things about your program~ in part
from Jan Volavka who hears from Mednick, and in part from Seymour Kety,

has presented the findings of your studies widely. Last I heard
Sarnoff was planning another decade of study plus an adventure ior the
Who in Hauritius. I hope these go well.

who

studies continue, focussed on EEG and drugs-— now
the narcotics, cannabis and their antagonists, as well as the special
problems of ECT. We have become the local experts on the narcotic
antagonists, particularly cyclazocine and naloxone, and have even been
asked to plan some studies of cannabis in Greece. (These are unrelated
studies, but there is a great overlap in the funding of the narcotics
and cannabis). Volavka seems to be enjoying his work although he is
Our own

concerned about

life in
is

New

York.

and in college and away from home. The
girls, 12 and lé are doing well in school . Martha is teaching first
grade and seems to enjoy it very much.
ﬂy son

now 19

about calling us the next time you are in New York ?
My staff would love to hear about your studies first hand, and I will
be pleased to arrange a seminar. Please call.
How

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>Hey 10. 1968

Dr. E. Ned Schultz
Director, Medical Affairs
E. R. Squibb &amp; Sons. Inc.
460 Park Avenue
New York. New York 10022
Dear Dr. Schultz:
On my

enclosed

return

summary

would be useful

from the Sitges conference I prepared the

for presentation to
to you.

my

staff.

Perhaps

it

take this Opportunity to thank you for your kindness
during the meeting and your recent consideration.
Hey I

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>August 20, 1963

m.

Anselm Sohwgaet
130 East this Street

Widen, Connecticut
Dear Anne:

It was a mat

If my calculations

surprise to get your letter.

amoorreot. ittasheensixteenyearssinoewe firsttalhedabout
In the last ten. devoted as they were to Hillside Hospital,
I fours: a lot of pleaeum in developing a research program Despite

psyordatry.

the psychological

framework

of the mspitel.

more than om~half

the

petimts were treated with psychouopie
. electro convulsive
turepyendimulin,andco1mabletof dmuohthatiuterectedm.
Sims scrim to Miami. the biggest diffsreme is in the changein
population. Psychiatric patients who are in State Mspitals are in
terrible shape 'Ihey consist of treatsmt failures but also a large

mnhermeoeialmroeasts. l‘orthismpthemis littlsthstoan
hedonsmsdically. Smaslwalktm'ougzthecewsrdsand
problems of large mom‘s of patients and few staff.
as'

the meldiswihution that exists, case of the adolescence fury and

protest.

again.

whiohmsomimntmnmmtogem. cemeteries

Itmforthismasonthatlmeverypleasedtomadyour

Idohope
Mammapcyeldatriohsspital.
in getting
started and can dmnstrete the

youare cwosssful
it
utility of your metteds.
Anything that can premt the prolonged Mcpimlizetion of patients,
would be

View at this point.

frailyhasbemsbletomkea
SimsmvingtoSt.Iouic.ey
My son. who is now 12, has
my {views
madmtolnvetakmuohoﬂahiceducatiomlmhissociallife
mmleftoffinllew‘rork. Ihavetmdaughters. age'lands.
satisfactory adjustment.

art},

of

My

commas.

many

their adjusmsntmmosteasy.

We for your kind wishes.

Sincerely

yum,

Fink. M. D.
m
Director

,

�</text>
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    <fileContainer>
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                    <text>,

-

-

.

v-v—ur—w-wv-‘.v—.~.--1W_..w....~. "mun-..”

ﬁr“..- .—nw.-...w,...,

.....m~~«_ :....r-—w-v...w.m.n.w..e.._....._.w....v.

“V"...

.—w.7

.,,

.....(“chit-mn,_1~..r..~..-.....

w

e...,... .._._..-w_ -. ...

—

.r,

..

m.

September 16, 1975
John

J.

schwab, M.D.

University of Louisville
P. O. Box 1055
Louisville, Kentucky

140201

Dear Dr. Schwsb,

Nikolovski,

I

am
M.D.

pleased to write e

letter of reference

on

behalf of Oliver

Oliver Joined my staff at the New York Medical College about 1968.
after his training at the Missouri Institute of Psychiatry with Professor

Turns

Itil.

'

,

Dr. Nikolovski was assigned to outpatient clinical evaluations of
psychoactive substances at the Metropolitan Hospital. The initial exper—
iences were difficult, since the population was largely lower—class and Spasish—spesking, providing all of no with serious handicaps in the evaluations.
Oliver did well. however, and became a principal assistant to Dr. Jovan Simeon,
the unit leader. Together. they completed evaluations of some antidepressant
and antianxiety compounds in these outpatients.

new

V

In 1970, the Department chairmen, Dr. Alfred Freedman, asked that I
transfer Dr. Nikolovski to a newly established community clinic, where he needed
a principal psychiatric therapist. He has continued to do yeomen service at
the College in this position.
Lately, he has been helpful in evaluations of a putative memoryenhancing compound, studies that have been undertaken by my co~vorker, Rhea

Dornbush, Ph.D.

Oliver has extensive clinical experience.

He

is intensely loyal,

dependable and reliable. He is meticulous in his relationships with the staff
and the patients. He is personable and likechle, although at times he appears
ohseqnious.

training qualify him for that posi—
tion described in your letter as functioning in an outpatient clinic with 255
of his time dedicated to research. It is a pleasure_to recommend him.

I believe his experience

and

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

.

.

�</text>
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E

E

E

E

E

Nhy 17. 1953

m. Ibhért 8.

SM

MW

Manama-m Guam Hospital
Beaten 1»,

Mfr. 801mb:

Recently you presented a classification of your

mm.aswcllasaclasaiﬁmtimofmmbjm.
I am in the process of establishing a awaifimim of
th- monda of this mm mm, and I should be. grateful
if you could and no a copy ofthe classification fem

demlopod in year laboratory.
Many

thanks for your cooperation.

_

Sinmraiy yours,

Hva

Pink. M.
m
Mater

D.

�</text>
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wm—s—wwwu-m

September 30, 1968

-

rpmmrp-nn

nun

Dr. Otto Schwarzkopf

Schwarzkopf Microanalytical Laboratory
56-l9 37th Avenue
Hoodside, Mew York ll377
Dear Dr. Schwarzk0pf:
we

would appreciate your analyzing

diacetylmorphine delivered with this

that it is this

compound, would you

measures as previously to determine

It is possible that this

morphine or

inert substance.

Thank you

this

sample of

letter. Assuming
please make similar
its purity?

sample contains up to

for your cooperation.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

5%

�</text>
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“7v

4'

»-‘.rv~v-;“-.. ,_ Iu'w~4'-’r ——.W,. «a»... NN..n‘V»m..—-.r.,.wmmr—wmm‘...

TO:

Mr. Schwarfz

FROM:

Dr. Fink

v.3...wm-..

‘.‘.._.._.v..._

ﬁn.“ "w.“

”\wauwr ..

DATE:

..

V,

.,

n...

‘

.

.

May

m,

.. 7,...

19,

SUBJECT:

I.

concur in Ken Skrlvanak's recommendafions wITh
regard to fhe Division of PsychOpharmacology.
How

I

are fhese

+0 be implemented?

2. Can Tradeaoff an office af Mef for The one
usad 3+ £02nd Sfreef?
I

Mszp

Ken

,

IQCQ

�</text>
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                    <text>October 21, 1969
TO:

Mr. Schwartz

FROM:

Dr. Fink

I have received a request
rooms:

for shades in the following

Room 1539a
Room 1589b
Room 1589c
Room

158910

Room 1589 4
Room 1589 -

Main

Office

H

yellow

~

104 "
H

H

2
2

Dark Green - 104 "
yellow - 104 "
yellow —72 "

1

yellow

6

—

72 ”

These rooms are used not only by the Division of Biological
Psychiatry, but also by the Training Division and soon by
Dr. Denholtz.

MF

:kp

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

DATE:

January 25, 1971

M.D.

are operating at a 21 bed capacity, although we have 25 beds
for a variety of reasons, chiefly monetary and space. The units
changed from a detoxification, revolving door facility to an extended
treatment facility many years ago. when 128 was reclassified as general
We

psychiatry,
and

we

remained on

15A

where:

(1) Staff ratios were low,
inpatients with the same staff.

and we had

(2) Space on 15A had been assigned to
the medical supervision of our patients.

to treat outpatients
2

laboratories for

(3) Once we were committed to an intensive, careful study
of opiate dependence we filled fewer beds to provide adequate medical
care and increased our CPU load. we now have lOG patients in continuous

aftercare. During hospitalization we detoxify, treat medical illnesses
(of which there are many) and induct on methadone, cyclazocine or naloxone.

MF:kt

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

SUBJECT:

DATE:

April 21, l97l

M.D.

Neurology

at

Kirby Manhattan

Psychiatric Hospital

Would you arrange for Dr. Morell to visit Kirby Manhattan.
to assist in the assessment of the neurological cases and in the training
of the staff? I have asked the residents to summarize the relevant problem
cases, and these summaries are attached.
When

regarding the

he

staff

Thanks.

is prepared to visit.

arrangements?

would you ask him to

call

me

�</text>
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                    <text>.

I.

TO:
FROM:

B. Schwartz

DATE:

July 9, 1971

Mu Pink, “.11.

SUDJECTé

Division Coverage

I will be

away

July

10

July

—

23

(approximately) on the

following visits?
July 12-13

In

Aberdeen

Narcotic Antagonists

14

Edinburgh

Opiates

15~21

Athens

Marijuana Study

absence, Dr. lake is responsible for the addiction
programs,
Dr. Abrams, the Kirby and Met~ECT—psychopharmacology
and
my

programs,

Dr. Volavka, the programs

MF:kt

at

5

East 102nd Street.

�</text>
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              <elementText elementTextId="49812">
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                    <text>August:

so, 1972

EEEQEAEEEE

To:

1. B. schwartz

FROM:

Max

SUBJECT:

Attached

The

Fink,

M.D.
PD

attached

PD

Form-

forms U111

transfer staff to

47-072—7, follow—

ing the guidelines of Mr. DcLucenn; use son: ”on campus" funds of

the

KIHH

contract 41r809~lg

and do son: housekeeping

41-382~3 which ends 9/30/72. and providc
and a change

in

my

for

some

to close out

leave for Br.

Crown

status.

Missing 11 ch.

PD

for: for

Dr.

antanaga.

Also. ch. juatificction page: for Mt. DcLucanc (to be added

to rcvitcd budget)

and a request

to hit! a nuts: to rcplacc Hrs.

Thomas.

�Giordano, ruignod to toko position in mother city.
plocuont deferred to Soptonbor.

D.

A.

Thoau promoted to coordinator of inpatient oorvicu.

plnconont roquutod.
B. Riemann)

J. Roldan)

B. Boddio )
R. Mayan )

RoRm-

Rouarch uoistmtu and technician: mignod
during July-Auguot. Replacements appointed
includo:
Loslio Suntan, Pat Sibony,
Carolyn Poinior, ﬂark Koala“. (1/2 time).

L

replace am of the services of A. Thomas, as coordinator
of the cyclazocino trutment program. we have promoted .‘iiso
Frmces Waiter at a higher salary.

To

hov- oxtonsivo data requiring are-programing of our
computer unit. Ho roqunt the addition of Ira Snapper, progrmor
analyst for six months, offoctive 9/1/72.

We

now

-

�</text>
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            <elementTextContainer>
              <elementText elementTextId="53012">
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                    <text>IR. Echvtrtl

T0:

PM:

M15:

staining in a:

1971

buoyant“

LN. hu burn “had by Dr. Hanna
«ch «7 u: mtmolitm Kupiul. Since
bun working both at Kirby and mtropontm it. 1. Manama

mum
Much,
and

to sign in

she has

July 8,

Pink, hid).

Max

SUBJECT:

DmTE:

out

Miss Durbin had bean signing for but
she
to Kirby, but. this is mmpnblc.
was
assigncd
the
days
on
would it be possible to «Intact have hot sign weakly, or no: sign

for he: to accomplish this.

at all?

Thank you.

arm:
cc: Dr.

Katalin

.

.a:

Li

�</text>
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              <elementText elementTextId="49852">
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                    <text>December 6, 1972

EEEQBAEREE
TO:

I.

FROM:

Max

SUBJECT:

Equipment at Wetropolitan HOSpital,
5 East 102nd Street.

B. Schwartz

Fink

All equipment listed

was bought by

NYMC

Antagonist Study) and is so labelled.

under

to

NH

he moved to

12567

(Narcotic
Total

To 102

8

5

1

1

18

10

3

1

3
1

1

1

sides)
single pedestal)

Desks (brown top, black

(each 30 x 60,

Desk

Brown “wood", double ped.

—

Chairs

w

Black naugahyde, some with arms,

S one

s t raigh t

Colored (red, orange, white)
Executive chair, brown

-

Chemical lab (green)
Cabinets ~ (black or grey 5-6
Desk

(
'

Table ”wood top”
Shelving units
—

ft.)

10

File cabinets

It is

my

1

3

0
3
1

that the number on the right be released
East 102nd Street as soon as practicable. Nurse

recommendation

for transfer to

5

Sonna Durbin has made the inventory and can act as liaison
identifying units to be moved, storing contents, etc.
The

3
1

shelving contains

EEG

These should be moved to

5

for transfer,

records from the psychopharmacology studies.
East 102nd Street as well.

�</text>
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                    <text>H-ZJC

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
Mr. 11 B. Schwartz
TO'

Max
FROM:

Fink,

June 29, 1970

DATE

M.D.
SUBJECT

attached

memo

Please request honorarium of $50.00 to be issued to Dr. Sarnoff Mednick,
2 Perry Street, New York, New York 10014.
This should be charged to
Research Training Funds and is for seminar which he presented on
April 14,1969.
Thank you.

mm:

Kﬁ}’:i

2X5

�</text>
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                    <text>M E M O R A N D U M
_——————.—~-—-«-——.

June 23, 1972

To:

Irv Schwartz

FROM:

max

Fink

I have reviewed the personnel previously assigned to the Psycho~
pharmacology Clinic and the various budgets. I believe the following
assignments provide for the continuation of programs, and a proper

utilization of funds.

Miss Sonna burbin and Miss Doris Giordano: These two research
nurses are devoting more of their time to the drug abuse service.
They are budgeted on 47—072~7. Dr. Levine has indicated that Miss

Durbin's time is now almost fully occupied in the drug abuse program,
and her assignment should be clearly designated as part of the addic~

tion program.

Miss Giordano has committments to the BCT program, and as Dr.
Taylor implements his lactate program, he may wish to utilize her
time. I suggest she be reassigned to the clinical services, and her
salary be paid from the new grants awarded to Drs. Taylor and Abrams
(to the extent they wish to use her time), and in part to that budget of the clinical services that support the treatment program,
notably ECT. The researdh aspects of ECT are no longer funded as
a separate project.

I endorse the request of both nurses (attached) for a review
The job descriptions should be modified slightly,
but both have exhibited a flexibility of assignment and a willingness
to assume reaponsibility that has been most useful. (Appropriate
of

their salaries.

levels

may

be $12,700 for Miss Durbin and $11,500 for Miss Giordano).

�Jr. Irv Schwartz

June 23, 1972

Pedro Gaztanaga, H.D.: He is working full time in the training program. It seems to me that if his salary is to be paid from
47~O72—7, we should assume he will have some relation to the addici
tion service. At present, there is no opening. Should the training
division wish to use his services, a fair guid pro guoﬁwould he the
assignment of residents, in rotation to 15A, on an equal basis with
residency assignments to 13A or 133. Lacking such a rotation, I fail
to see the justification for the use of these fund (47—072—7) to sup—
port clinical teaching away from the drug abuse treatment unit.
The remaining assignments of personnel and budgets of 15A seem
appropriate to me, (iiEia 47-072—7 and the personnel assignments of

the

15A

Addiction Treatment)units).

�</text>
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                    <text>June 2“, 1965

Mr.

Irwin Schwartz

York Medical College
5th Avenm at 106th Stmst
New York, New York 10029

New

Dear Mr. Soluar'tz:

I enjoyed

my

visit on

Monday

with your

staff,

and indeed

the only disturbing note was they news that you were having
some diffiwltiss with the building on 105th Street.

Dm‘ing the day I not with Dr. 'Shamff and his associates,
Dr's. Sorvino, Solmsdek and Major. modisoussim centered
about the two principal research program planned by Dr. Fmedman~

blocking of heroin addiction by oyclazocine and methadone.
Dr. anroff and his associates have had some mosual results
in their first group of nine patients.
There

is

need

for mplioatim, and for

some

additimal

studies to oognplsmnt the clinical observations. Truss types
of supporting studies were discussed: biochemical examinations
for X's-exposure to heroin, psychological tests for the evaluation
of personality of addicts who any or may not respond to such
studies to masons the duration
tmstmt and murophysiologiosl
of blodcing notion. Dr. Shaxoff and his staff are well equipped
to omy out the second and third parts of these ancillary program
but will probably need better supervision for the biochemistry.
if codified,
It seems to me that their experience is sufficient,
NIH
of
the
an
to
planning
application to
or to other

mt

for support with which you may be acquainted. I left
scum
Dr. Sharoff with the mooamdstim that his associates write

upeaohofﬁmnijmoasesinashort
I muld

be pleased

to

mview these.

‘

(2 page)

swansryandthat

Dr. Stamff invited as to sit in on his staff meeting,
following which I lectured on the subject "EEG in Psychiatry,"
During lunch with Dr's. Scrmeok, Losmnkopf , Shamff and Sowino,
m oontimnd to discuss the drug addictim problem.

�Mr.

Irwin Somartz

~2—

Dr. Sorvino presented the model

June 2a, 1965

of establishing an

EEG

laboratory for clinical investigation. I indicated that it
was probably difficult to establish a second clinical BEG
laboratory at Metropolitan Hoopital, but that a research
laboratory dedicated to the problem of the drug addict or
to the other projects of the department could probably obtain
support. It became clear that Dr. Servino was very Immh
interested in carrying our neurophysiological studies in drug
addicts. To assist him, I gave him some reprints of work that
might be helpful to him. I would like very such to continue
our discussim at the next meeting.
his interest in 1301’. At an earlier
visit
interested in carpeting Indoklon convulsions
with electrical convulsions. After reading sous comparative
literature and in the worse of our discussion he seemed to
focus more on studies of the mode of action of ECT. After
describing my experiences at Hillside and the corroborating
studies of others, we seesed to agree that a predictive study
of the EC! process could be undertaken at Metropolitan. I
indicated that to types of data would be necessary, psycho—
logical tests and neurophysiological indices . It was apparent
that if Dr. Sorvino established a research EEG laboratory,
Dr. Schneck could obtain the necessary EEG data. For the
psychological test data, however, he would probably need the
collaboration of a clinical or experimental psychologist. He
suggested that he arrange for the three of us to meet during
my next visit.
I also pmnised to send him sons literature
which I we doing under separate cover.
Finally, I spent some time with Dr. Ioewenk0pf. We discussed
his program of drug evaluation in the out patient department.
As he described his interests it seems that he is less interested
in the testing of new ccnpomds than in developing predictors
for the application of the drugs. We discussed the Domstate
Psycl-ophannacology Program and also some of the behavioral
typology approaches developed at Hillside. Since Dr. Sorvino
already had the references from Dr. Overall, I suggested that
be «mad Dr. Sorvino get together. Since I know Dr. mgelhardt
well, I indicated that I would write to him and obtain sure of
his reprints. I also suggested that I would send Dr. Loewenkcpf
some of those from Hillside and that we should be able to
oontinm this dialogue after his vacation.
Dr. Schweck discussed

he seared

�Hr. Irwin Schwartz

~3-

June 2'4, 1965

I am inpresscd with the enthusiasm of your staff and believe
that a umber of projects can be stimulated. It may be advisable
for me to return to New York in mid-July, to meet with some of
these staff numbers and any others that you would care to recommd.
The date is probably irrelevant and I can suit your commence
(:1 any Monday

or Friday.

I had the enclosed

forms with me

but decided to send

you personally as Dr. Freeman had requested.
am

to

also enclosing a statement of my expenses for this trip
well as a receipt for the air rpmspcrtion.

I

am

'

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MP:kp
‘

them

enclosures

�DEPARTMENT OF PSYCHIATRY
NEW YORK MEDICAL COLLEGE

Expenses in consultation and lecture June 20/21, 1965:.

Air Trmsportation

$108. 00

Gmmd Trmsportation

8 . 00

Total

$116.00

�</text>
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                    <text>Jammy

Hr. Irwin

10 , 1966

8W3
of Paychiatry

new at

Nadia]. College
106th Street
5th Avenue

New Yogic
New

York,

New

York 10029

DearIrv,
Dr.

Itilmdlhawbeenworkingmamseamhpmgm

m the mutant of m mm mtally 111. knowing of your
interest in the problem of mhabmtaticn, we mum be pleased
and am writing
to have you participate in this study
Western
that
during
us
visit
masses!
forthmudng
you
your
:31

pm'

9.

My

best mgams.
Sincerely yams ,
Pink, ”.13.
Professor of Psychiatry

Max

HP:kp

vow-.mwv—awrwmnmxvyrwvm—

-

y-vm—

rm

.

�</text>
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                    <text>May

2, 1991

Dr. John Schwartz

Inc.
Tustin CA 92680
CME,

730 El Camino Way

Dear John,
An

old friend wrote the enclosed note in response to
New York. I thought you would like to see it.

the events in

As a confidential note. Linda Andre, the woman who
intruded so emotionally in the course, is not accepting a
reasonable settlement of her malpractice suit. The lawyers
called this week to say that they were preparing to go to
she apparently wants her day before the media rather
trial;
than a reasonable resolution of her complaints.
I look forward to seeing you in New Orleans. My best
regards.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>April 30. 1979
Marc D. Schwartz, M.D.
26 Trunbull St.
New

Haven, Conn. 06511

Dear Dr. Schwartz,
Thank you for the copies of the past issues of Micro-Psych.
Psychiatrists were among the firstvphysicians to see the merit of
digital computers and the present enthusiasm based on smaller and
less expensive devices continues this drive. There are many
excellent applications vhich are being developed and I expect such
devices to be as secure in clinics and offices in the 1980's as
typewriters areztoday.
Our initial interest in digital computers was to reduce the
tedium and inaccuracy of hand counts of EEG and ECG wiggles, and in
measuring the changes induced by drugs on behavior. My first digital
computer EEG analyser was established in 196h at the Missouri Institute
of Psychiatry (IBM 1710) with the support of the staff of the Computer
Center of Washington University; second an IBM 1800 system developed in
New York in 1967, by D. M. Shapiro, D. So. This system is operatidnal at
SUNY at Stony Brook and consists of an IBM 1800, 36K memory, 2 disks,
printer, typewriter, card read and punch and assorted other gear. The
system has steadily churned out EEG analyses using period analysis and
power spectral density analysis for the initial data reduction, and I
wide range of statistical and display packages for later presentations
(t—test, AHOVA, AECOVA, linear and quadratic regression, etc.). The
system analyses tapes from drug studies ~—- about 8/year from our
laboratory and as many from outside laboratories that collect their
data and ship the tapes to us for analysis.
‘

also developed an interactive diagnosis system based on a CD0
interactive display terminal (one 217A with digiscribe) and an IBM ass/ho.
The programs were written in PL/I (DOS) and were basedoon two diagnostic
logics --— that of DIAGNO—II develOped by Spitzer and Endicott and the
We

by Overall and Gerham. These exercises found such interactive
diagnostic systems very useful in research studies but their expense

BPRS

�M.

2.

D. Schwartz, M.D.

April 30, 1979

precluded a general utility. Those programs were published in 1971, and
I have-not gone book to that problem since, but the newer systems of
psychiatric diagnosis, particularly the DEM—III and RDC use logics that
allow computerization with little translation. I an optimistic that
some of your headers will be able to accomplish these translations and
programs for the smaller machines. Such facitity will provide the
necessary underpinning for a more systematic diagnosis system and much
better data for the inevitable revisions of D8M~Iv and —V which are
sure to come.

Quantitative EEG analysis is esteblished as a useful process in
psychOphsrmscology ——— to classify'and identify new psychoactive drugs
one to define their pheroacodynamic properties. Some references are
cited betas for the readers who may be interested. There is an oppor»
tunity for those who wish to collect EEG or ECG date on compatible tapes
(IRIG T~channel Annex SP 300, 1/2 inch; or 1316 h—chsnnel Hewlett Packard
3760A or 376b, l/h inch) to have them processed in our laboratories at
nominal expense.
Good Luck

in your venture.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

References:
Fink, M., Shapiro, D.M,,ssdckman, c. and Itil, T. Quantitative Analysis
of the Electroencephalogrsm by Digital Computer Methods. III.
Applications to Psychophsrmscélogy. Computers and Electronic Devices
,' in Psychiatry, (Ed.) H.S. Kline and E. Leaks, Grune and Stratton,
109-123, 1968.

Fink, M.,
EEG

Fink,
.

Itil,

:

T. and Shapiro, D.

in Psychiatric Research.

classification of Psychoactive Compounds in Man: Review and
of
Behavioral Association. Psychopharmacology A vaisw of
Theory
Progress, 1957-1967, (Eds.): ﬁ. Efron, J. Cole, J. Levine and
J. R. Wittenborn, v.8. Govtt.”Printing Office, washington, D.C.,
M.

EEG

—

pp. h97~507. 1968.

3

Fink,
.

Fink,

Computer Analysis of the Human
Qbmprohsns. Psychiat., 8: 521-538, 1967.

Digital

:

5.3 aes- S. and Fink, M. computer Aided Interactive
Psychiatric Diagnosis Programs. New York, Biodeta, Inc. 75 pp., 1971.
M.

in

M.

EEG

Profiles of Fenflurenine, Amobarbitel and Dextroemphetemine
volunteers. Psychogharmooologia (Barl.)'23:,369—383, 1971.

Normal
EEG

Profiles

Itil
Problems in
In: T.

Biosvailability Measures of Psychoactive Drugs.
(Ed.): Psychotropic Drugs and the Human EEG. Modern
Pharmaopsychiatrﬁ, Basel, S. merger, pp. 76-98. 19714and

�www—ssz

Fink,

Cerebral Electrometry: Quantitative EEG applied to Human
Psychopharmacology. In: H. Kﬂnkol and G. Dolce (Eds.): Chan M.

computeriacd’EEG

analysis.

Sﬁuttgart,

G.

Fischer, 271-288, 1975.

Empirical Comparison of Three EEG Digital
In: M. Matejcek and G.K. Sohnnk (Eds.):
Quantitative Analysis of EEG.“ Konstann, Switzerland, AEG Telefunken.

Irwin, P. and Fink,

M.

An

Conversion Techniques.

—.—

1“

379-39h . 1976.

AA.._,_—,_.‘V.

._.V

April 30, 1979

References continued:

-

_m

2.

Schwartz, M.D.

M. D.

:

Fink, M., Irwin, P., Gastpar, M. and de Bidder, H. EEG, Blood Level,
and Behavioral Effects of the Antideyressant Mianserin (ORG GB 9h).
Psychopharmaaologia 54: 2h9—25h, 1977.

Fink,

M.
Mania and
Manic Illness.

Mszc

Eloctroseizure Therapy (EST). In: Shopsin,
New York, Ravgn Press, 221-230, 1978.

B.

(Ed.):

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                    <text>u—n

&lt;"1“"-anr-

"v—AVWWn

'—'

v.

«w»

.v

-W

-,

~«r.A~———

‘
m-

vaewr.»

w

"1."

August 15, 1988

'
"

l
""

"
c

Mr. Ronald B. Schwartz
4916 Conrad Street

Skokie, IL 60077

""

.

"—"'"‘

‘7

Dear Mr. Schwartz,

.—

‘7

‘

A

Mr. Buckalew contacted me and my response was to advise him of the
variety of videotapes and audio cassette recordings about electroconvulsive
therapy in which I have been a participant. I did not make a special tape for the
library. I am unable to transfer the copyright to any of these recordings.

‘

WWWMMW-

‘-

Good luck in your efforts.

Sincerely yours,

_—

v.1—

«mm

Max Fink, M.D.

Professor of Psychiatry

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                    <text>WW-«nuanm

"zanww-hwu-oc

--..

a.

use

x..u.—..

“van-lawn“

-.

.

w

r‘

V"—ir-‘

'r-

\V-w.u_.._~,_m.w...

October 17 , 1967
Dr. Otto Schwartzkopf
Schnertzkopf Micmanalytical laboratories

um»-

Ara.»

'V—vn

56~19 37 Avenue

Flushing,

Tim‘a‘ﬂ

aw:

New

York

.375,-

Dear Dr. Sommacopf:

.5“,

discussed on the telephone, I am serxiingyou by
two
capsules, each presumably oontaiming mugs of
messenger
“Heroin Hal. (pure) Reorystalized. " We would like you to
As we

‘ew~u,n&gt;w—‘ITV

A

carry out such analyses of the denies]. and physical properties
of this compound as my be necessary to answer the following

y.w-vu¢rvwml¢uwkunpy~

questiOm:

is the purity of this sample (what percentage
of heroin does it contain)?

um...

What

Ms

note

is

for this catalysis.

.r,

an autlnrization

to bill us

up

to

$100. 00

“pm-v.1."

For your information, this sample was derived from a
govemsental agency and is part of a sample used in a study
pmgzm at this college.

“up-van

',.~ww,.,.,vr..~WWW.”

Thank you very Mich

a."

for yaw help.

.._

Sincerely yours,

‘Wv

Av'nw'-

'ﬂm“'ﬁ

)w

m

~$r:"-

Fink, M.D.
Professor of Psychiatry

Max

m»
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we.

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                    <text>June 22. 1966
‘92

“)‘z

M
'

“t5

\f

wgciyk .hasar H. Schwars-vittpar. H. D.
Y I
80, Sokolov Street
/’
Cholon. Israel
1

Dear Dr. Schwars—Pittpar:

thank you very much for your inquiry. The Hissouri Institute of Psychiatry
is the research and training center of the Division of Mental Diseases of
Missouri. It was established in October, 1962, with laboratories and
clinical facilities for research. At the presont time, of 150 beds, we are
utilising 70 for research purposes. Laboratories are established in phsrmn~
cology. psychology. and electroencephalography. as well es a computer
center for both statistical and EEC analyses. There is a specialised
psychiatric research library as u component part of the Institute. Animal
facilities are now being built and will be completed by the end of the year.

present time. there are e number of research programs in progress.
These include Lithium as a therapy for mania; the use of Yohimbine as n
precipitant of satiety and the development of snti~snxicty agents; relation
At the

of EEG patterns and organic factors in the treatment of therapy resistant
psychotics; computer enslysia of the electroencephalogram; the effects of
drug withdrewsl on behavior in the chronically ill; the evaluation of new
psychotropic drugs is part of s national early clinical drug evaluation
program.

In neurophysiology. we have the following major programs: Dr. Turan Itil,
formerly of Erlangen. hes established a program in evalusting the 286
changes with psychotropic drugs and relating those to the behavioral results.
Dr. Takuei lk’uta has established a complete laboratory for the study of the
cortical averaged evoked potential and is now determining the stability of
this method in our pntiouts. my own program is dedicated to determining the
interrelationship between different methods of EEG analysis. and efforts to
quantify these, and to relate these changes to behavioral changes so reflect~
ed in psycholinguistic methods.'

ptaaent,tine, the Institute is planning to expend these prggrsns in
the coming year. us are inviting the collaboration of scientists whose
interests are compatible to our own and who wish an appprtunity such as this
institute provides. and are pleased to consider spplications.

At the

�Dr. Schwarz—Pittpar
6-22-66
Page Two

I plan to be in Iuranl during the period August
to discuss this opportunity with you in person.

I

4

to 13.

and would be able

appraciatc a copy of your curriculum vitae listing chronologically
your educational and professional eupcrionce. In addition. a small photo»
graph and the name: of at least two rafcroos to whon'we may write would he
would

not: holpful.

Sincorely yours,

“‘3 Piﬂk.
Dictator

HF/jb

H. D.

�</text>
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                    <text>July 7. l969
Dr. Otto Schwarzkopf
Schwarzkopf Microanalytical Laboratory

56-19 37th Ivenue

Woodside,

New

York ll377

Dear Dr. Schwarzkopf:

Enclosed is a package presumably containing heroin.

it
heroin

possible for you to estimate the amount of
available? It is important for us to determine the
amount that our subjects are taking from the street. The
degree of accuracy for this determination is not high.
We would be satisfied to know the amount to the closest

Would

be

milligram.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
ENC.

�</text>
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                    <text>3‘.

w

June 20, 1978

Paul

Schyve, M.D.
Illinois Mental Health
Chicago, Illinois
H.

Institute

Dear Paul,
Thank you for the fine review of the relation between
prolactin elevation and breast cancer. I found it thorough and
rather disconcerting.
During the past half year I have been working on the
review of BCT which will be published later this year by Raven Press.
In trying to assess the relative efficacy and safety of ECT and
drugs in depression, mania and schizophrenia, I became more and
more aware of the many risks that our patients run in taking
medication. Now, I have added a citation to your review. On balance,
it is clear that drugs are safer and more effective than ECT in
schizophrenia and mania, but the issue is far from clear fer
depressive disorders. In fact, if one had to write an opinion today,
PCT is safer and more effective than any of the trecyclics. That is
the reason I was so interested in the review of mianserin.

In any case, thank you again. I am sure the review will
meet the standards of the Archives and look forward to its publication.
My

regards.
Sincerely yours,
Max

rm,

24.13.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="100882">
                    <text>Jum 11,

1963

Box 138

SCIENCE

1515 Massacimsetts Avemu. NM.
Washingtm 5. D. C.

Dear Doctor:
‘me Missouri Institute of Payahiatry is a newly established
research center devoted to inmstigatims in psychephamacolog.
brain fmctim and behavior. Aippaintxmts at the principal scientist
(Sam Gemini. H. 0.),
level have almady been mach in

mmhyaioloy (Mn Itil,
{aurPh. 1).). In

m
Mmion

and

Wag};
D.) and psychology (80]. Garfiald,

M.

clinical psychiatrists are on the staff
additim,
patients in the Institute section. A
of the Institute is wetland.

msmible for the

Initial studies of this prom m devomd to tha asusmnt
111 Mindor- and the influence of
of brain molimrga
Lithium ion on blood and spinal fluid eloqtmlytes in psydmotic
subjects. whomtm facilities in ,ptmlogy and biodmistry,

W538

'

asmuasaxﬁmlfacintios,mnmunderemmctandshou1dbe

for positions at the Institute am
Division
the
of Mental ‘Diaems- of tho State of
thrmgh
provide:
completed by October. Funds

mam .

If this msumh possibility is of interest to you. I would
bepluaaodtommiveaoopyofyowmicuhm vitaandtomam

the masonry arrangements to discuss this further.
Sincerely yours,
MEX

’1me

m.

Fink,

Diractor

M. D.

�</text>
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                    <text>‘Novunber 23, 19%
Box 539

mmm
0..
Wm.
Sir:

‘SC‘IENCE

1515

D.

Avenue. NM.
20095

Dear

The Missouri.

Institute of Psydxiatr‘y,

new

a

Division of the Immunity of Misswri School of Madicim,
and mo—
ha mamtly established a not of
physioloy Wtor‘ies in support of the principle program

of

march in paydwphmeoloy.
in

W103;
We

are interns-had

new

in developing a laboratory clinical Mum-bath as
a supporting unit to the alinioal'ps'ydwphmmoolby pmgzms, and for mic march.
Ms Institution was established in Sepmr,
1962 and effective January 1, 1965 hams a Department of

mm.

I
the School of Maire of the {hivemity of
enclosing a copy of our first mam}. report which provvidea the best awry of the structure of the Institutimt

a

Mpositimismmdemicmemdifit

intmstsyou, Imldliloatommiveaoopyofyom‘

mm

vitae.

‘

Sincerely yours,
Mm:

Fink,

Dimmer
mfﬂs

enclosm

M.D.

�</text>
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                    <text>Jammy s,

1965

Ben: 5H3.

301mm

‘

1515

WWW; Amt. NJ}.

Hashingtm, 13.0. 20005
Dear Sir:

mnepmt

Wm

of
at the Missouri Institute
of Paymistry of the. [adversity of. Missouri School of Medicine
has moontly established a u»,\ tattoo center for the mural
mum sciences After a demmtmtim and study pomod, the
principlesofooominatoindmdngmdaeidedasﬂmwis for
Wopmm.
'medomntommthevaﬁeﬁesofjmmals
in the mtal Mama field.
~

tim the 929;” is being «paraded mad
Watalists mo shﬁlar pummel are

At the pmsent

sdditimal abstractom.

being sought.

vitae,

We

would be plowed

to have you submit your curriwlun
to you.

if this opportmity appears of interest

Sinoerely yam-s,
Max

Pink,

PM).

.

Professor of Psydﬁatry

�</text>
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                    <text>May

10 , 1968

Box 143
SCIENCE.

1515 Massachusetts Ave..
Hashingtm. D. C. 20005

NW

mar meter:
-

Mamparmentofﬁsymiattyinsn Wishes

facilities in mumphysiolow.
mam
and bimstry. With the expander: of
Wicca. we are interested in the appointmt 0f
WW.
additimel pemml, and your advertiseeent interested
own program are dedicated to Wysiologieal
me.
teammate in psychiatric Meats with pawllsl studies
developed

My

inthe 3mm

mm“.

I ammseekingtmaesistanee
ofaco—uorkervmocandsvoteamjgmpomim ofhertim
to the animal labmtety studies , with specific emphasis
m the testing of EEG Mid balmviml effects of various
in dog and Wye. Positions in
paychetmpic
thievexmntmmafulltimebasistmytm
perquisites of the mivemity of Hissmi.

W

Immcloaingamwoprtblicatimlieteatmt
ywememidanefﬂaekiMofstndimwhidzIMm
mdsrtﬂceninthepwt.
to

If this

appointment interests you. I would be phased
receive a copy of your curriculum vitae

Sincerely yours.

Firk,
m
Professor of Psyduiatxy
V1.99

MP”!!!

Enclesm

'

�</text>
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                    <text>My 10 , 1965
Box 155
SCIENCE.

mm

1615

Wmhimtm.

13.0.

‘

Ava... aw
20005

harm:

Tm Deparment of Paydﬁatry

of Psychiatry in St. Louis is

immry.

For

m

at the Hisaouri Institute

1m animl
time we have bean intanasted in
new completing

W.

You may
expanding our electwhysiolmoal
be acqminmd with the EEG studies which have been undertaken
of me
by
incluins rm. 6. A. mutt,
11:11, and mysalf.

Wm

m

As

a

Wt,

admit): departmt,

our primary mission

is

in tho duvelopunt of museum prom relating to the
of tin mntally 5.11. and in the training of psydﬁatric
cm
mitigate. me facilities include clinical wards homing
up tc 150 patients , laboratm'icw in mumphysielogy,
library and our
Wmmlow, and Matty; a.
.

mn

«2mm

center with an

W-

IBM

1710-16203 emanate».

the
any
this
Opportunity
If
inﬂmtsym,1wouldbcplmdtommimamwof
maimlum vitae.
Appointmnta am on a full time basis
Muskeg of the University cf Missouri.

mad

your

Sinéamly your-n ,
Max

Hfzjm

Pink,

34.23.

Professor of Psydﬁatry

�</text>
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                    <text>April 7,

1967

Box 387

Science

.

1515 Massachusetts, N.W.
Washington, D.C. 20005

Dear Sir:

of Psychiatry has recently developed a
computer facility for the study of neurophysiological
signals and for other applications in psychiatry. The central
computer will be an IBM 1800 which will be delivered early in
The Department,

digital
May.

Among

retrieval.

the special applications are those in infomation
.

I am particularly interested in individuals who lave an
interest in canputer programing with a medical bachumd.
,

This position

Fifth Avenue in

is in the laboratory at 102nd Street and
York City. If this interests you, please

New

call my secretary at

212 369—7900

Btt.

2148.

Sincerely yours,
Fink, M.,D.
Professor of Psychiatry

Max

Mikp

�</text>
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                    <text>May

Box

2, 1957

ml

Science

1515 Massachusetts, MI.
Washington, D.C. 20005

Dear Sir:

advertisenent in a recent issue of Science regarding
a wish for an appointment as biostetistician is of interest to
us. The Deparment of Psychiatry of the New York Medical College
has recently anbarked on an intensive study program of the effects
of changes in EEG signals in relation to changes in behavior
induced by psychoactive drugs in mental patients and narcotic
addicts. The laboratory is equipped with an IR! 1800 system
and we are anxious to expert! the statistical approaches necessary
in the analysis of these signals.
Your

The appointment

is in the

Department of Psychiatry and would
psychophamaoology studies , evaluations

enconpsss omsultetion in
of mannent, and other related applications.

If this

interests
a copy of your curriculmn vitae.
appointment

you ,

I

would

appreciate receiving

Sincerely yours ,
Mex

Firm, M.D.

Professor of Psychiatry

�</text>
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                    <text>w

y1
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«.w,

waxy?

SCW-MIW

“Vivi“

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Juno

2’5,

1969

Soorototy

o! Roooorch rocilitioo
um annoy
Broio Bcioocoo

in

Notion).

lotionol

Mouth
Aoodooy

ﬂoohiostoo. n.c.

Council

of Sciooco

boot Giro:

hook you {or o copy at tho mo Botvoy of looootoh tocilitioo
ond Honpowot in Main Scioncoo. It io indood o moivo took. gonotolly
won. dooo, out o voluoo thot will hovo iuoodioto utility.
-

a

writing
io ooticipotod thoto oto oooo ottoto. ond I
tho out
to count oolo choogoo which ohooid ho incorpototod innow
York
tho
oditioo. I wito “cording tho oootioo doyotod to
hoodod
by
Llodicol Couogo. pogoo 213-215. rho fiool mogropho
"tho Btoio noooorch ..." contoio oooy ctroto.
Ao

Doportoont of Poychiotry. hoodod by A. ll. hood-on (Choinon)
(Editorial Boord. Anoticon Joutool Orthopoychiotty) hoo on oxtonoivo
lRho

in two
pronto: in tho tolotioo of broio function to hohoviot. dividod
N.
(
Pink.
principoi divioiono - tho Divioion of Biologicol Psychiatry
R.
B.
Ditoctot).
John.
Diroctot) ood tho ntoio Roooorch Lobotototioo (
tho Divioion of Biologicol Poychiotty io mootood with tho roiotion
of BIG chagoo ond hohoviot in non. opocificouy tho iotioonoocf

ioduood oonvoloiooo. poychotropic and holiucioogonic drugo. ond opiotoo
lobotototioo. coo with oo-iino
on no. no ﬁocilitioo includo thtoo
oooiyoio ooio; on Ila-1800 oyotoo; toot topo oyotono; and 25 bodo for
poychiottic tooootch. Tho ooiootioto includo Dr. D. u. Shopiro, cooputot

m

molyoio of biooloctric oignolo; s. Foidotoin, poyoholinguiotico;
3. Dornhooh. ooooty oochoniooo;
J. Volovko. nonotivo quootitotivo no;
H. Koolot. odvotoo offocto of
J. noobicok, BEG out! holluciuogooo;
hoilucinogono ood comb“; out! )4. Fihh (Ditootor) . quontitotivo
drug offocto. induood convuioiono. and hohoviot in poychiotric
m.
ouhjocto ond natal volootooto.

Division will mo to o tic-unity Montol Boolth Contot in
1970, vhoro opportunitioo to: ditoct clinicol - oourophyoioloxiool
otudioo win ho oxpoodod to o 50 bod rooootch unit.
rho dooctiptiono of tho Btoiu Roooorch Lobotototy oro oooontiouy corroct.
lrho

hook you for your cooporotion.
Siocotoly youro .

7123‘

“I",

“523:3!"

”C.

F
771.

I'm-mom»

Ho: Fink, 24.1).

Professor of Psychiatry

�</text>
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                    <text>wzvi-l‘t'n‘rwﬁva-upt-“VVJV1....

....,

.._. 7.,

.w

.

"W"

my W.

.-.».,¢....1,..W.

..-i._,..gzﬂ-mi.. 7...": ,v‘.. “n.-.

q

.pvwwwmc

.-:w»_r~u... m.

,

...

.-

r

-

--‘rn.' .,

,

www—

~.—--

_,,.._

“it my .. .,....1

,‘
v."

m

March 15, 1971

—._.,,~._.....wr-A.

.hwrwn...“

American Association for the
Advancement of Science
1515 Hasaachusetts Awe., N.w.
Washington, 3.0. 20005

m-....,.«_'

”my?”

wm—wuwwwmw

w“

Gentlemen:

I am writing with regard to invoice M74709f for 500 reprints
of ”Narcotic Antagonists in Opiate Dependence”, in September 4, 1970.
The invoicc is for $90.00.
According to our records, the reprint request was submitted in
July and at that time the estimate was $36.00.
would appreciate your checking your records
the invoice.
for
basis

I

and

verifying the

Sincerely yours,

WW&lt;

u’hwvvrﬁov

Max

Pink. M.D.

Professor of Psychiatry

Mr:kt

�</text>
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                    <text>May 15 ,

1967

Box n31

Science

1515 Massachusetts, N.W.
Washington, 13.0. 20005

Dear Doctor:
The Department of Psychiatry of the New York Medical
College is smarking on a series of new programs, mung
which is one dedicated to the evaluation of changes in
brain function associated with psychophamaoologic agents.
We are establishing
a research laboratory in HQ and computer

techniques of analysis. The drugs mder investigation will
be the majority of psycl'nactive agents , and the populations
will be“ the acute mentally ill and narcotic
addicts.

If such a study program interests you, I would be
pleased to receive a copy of your curriculum vitae.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MPtkp

�</text>
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                    <text>May

BOX

15, 1967

#53

Science

~

1515 Massachusetts, N.W.

Washington, D.C. 20005
Dear Doctor:

The Deparment of Psychiatry of the New York Medical
College is embarking on a series of new programs , wrong
which is one dedicated to the evaluation of Changes in

brain function associated with psychophamacologic agents.
are establishing a research laboratory in EEG and computer
techniques of analysis. The drugs under investigation will
be the majority of psyclnactive agents, and the populations
will be the acute mentally ill and narcotic addicts.
We

If such a study progran interests you, I would be
pleased to receive a copy of your miwlmn vitae.
‘

Sincerely yours ,
Fink, M.D.‘
Professor of Psychiatry

Max
.

,

"furry—”mu

.

-W—w

MP:kp

�</text>
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w

91.,

.p:«.,.-—»v,.-u-

y‘mmA-zmm1vwml

“Hr:(z&lt;xl-m-.g

July 6, 1964

'&lt;

Science Information Exchange
Madison Rational Bank Building
1730 H Street, N. W.
Washington. D. C.
Gentleman:
We

hnvo rocontly undertaken 3 study of the changes

in spinal

fluid protein. and enzymes in patients with chronic schizOv
phronio. This is a subject which attracted considerable
interest about 10~15 years ago and recently, may hawo been

now studies. no would ho grateful for dbatrccta
referring u: to studies now in progress in the following area:

subjected to

Cetobrospinal fluid, psychoain. protein chanson.
Corobroopinal

fluid, psychosis, onzymcl.

proteins and enzymes, we are particularly interested in
eloctrophorotic analyses of protain patterns, such enzymes as
cholinostorasco. MAD inhibition. etc., and such tronsmittera
an acotylcholino, serotonin. and various amines.

Undo:

Thank you vary much

for your cooperation.
Sincerely yours;
Fink,
Director

Max

MF/jb'

M.

D.

�</text>
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                    <text>January 10,

1970

Editor, Calendar
SCIENCE

1515

Massachusetts Ave.

Dear

Sir:

Washington, D.C.

we wanid appreciate inclusion in the calendar of
a record of the next meeting of the American Psychopathological
Association, in ﬁaw York am February 13«lé, at the an York
Eilton Hotel, on the subject of " Mona Discréers“. Requests

for information are to be directed to the Secrataty,
at 5 East 102 Straet, New York City.

Max

Thank you.

Sincerely yours,
Ha: Fink, H.D.

Secretary

Finka M.D.,

�</text>
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                    <text>September l2. 1967
Research Fellowships Sect1on
Behavioral Sciences Training Branch
National Inst1tute of Mental Health
5454.wisconsin Avenue
Chevy Chase, Maryland 20203
Gentlemen:
At the suggestion of the Chairman of the Department.
Dr. Alfred M. Freedman, I an writing on behalf of a resident
physician who is now in his third year and to whom we would
like to recommend the Mental Health Research Development
Program. We would appreciate an application kit and the
instructions for submitting an application. It is my under~
standing that either Dr. Freedman or I w1ll act as sponsor
and the candidate, Dr. Arthur Zaks,w1ll be CGMpleting his

resldency training in June of l968
Thank you

for your cooperation.
Sincerely yours.
'

Mszp

Fink. M.D.
Professor of Psychiatry

Max

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                    <text>May

2.

1968

Dr. John Scigliaoo

Center for Studies of Rarcotic
and Drug Abuse

ﬂationai Institute of Naotai Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

Dear 0r. Scigliano:
For many months I have been making the arrangemants

necessary to undertake naurophysioiogicai studies of marijuana
and its extracts. Before receiving the iotter from Dr. Mayer.
indicating that the supplies of these drugs can be obtained
from your office. I had uwitten to Commissioner Giordano for
the mariauana leaf.
we are equipped to undertake some preiiminary studies
of THC and wouid iike to make such axpiorations. At your
convenience. may we request 250 mg of THC for this initial

triai.

Thank you

for your cooperation.
Sincaraiy yours.
ﬂax Fink.

".8.

Professor of Psychiatry

Mszp
cc:

Or. Mayer

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                    <text>September 17, 1968
Dr. John A. Scigliano

Executive Secretary
ad hoc Merihuane Advisory Committee

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

In support of our application for supplies of tetrahydrecannabinol and marijuana, enclosed please find the
original of the letter from the Internal Revenue Service
dated September 12, 1968 confirming the official nature
of our special Tex Stamp number 405087 and Registration 127M.
As indicated in your letter of August 23, this letter from
the District Director will serve as an order form for marijuana.

Sincerely yours,

Professor of Psychiatry
Mszp
enc o

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                    <text>September 3, l968
Dr. John A. Scigliano

Executive Secretary

ad hoc Marihuana Advisory Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

Separately, I am answering your letter of August 23,
regarding the additional information requested by the
Advisory Committee which met in July l968. I trust that
these answers will satisfy your interest.
have a list of the present ad hoc Marihuana
Committee?
Advisory
May I

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ko

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                    <text>September 3 , 1968
Dr. John A. Scigliano

Mecutive Secretary

ad hoe Marimana Advisory Camittee

National Institute of Mental Health
Wisconsin Avenue
Chevy Cruse, Maryland 20203
51450.

Dear Dr. Scigliano:

for your letter of August 23 referring to the
Advisory Cannittee meeting of July, deferring my request for
legal supplies of marijuana and me for research, pending
answers to questions raised by the Committee.
Thank you

The following

are the answers requested.

First , let me imiioate that the BEG-behavioral studies of
any new drug are complex and while some analyses can be accomplished
with few trials, most require many experiments. The number of
trials (and the mnnber of subjects) are "as many as necessary".
For example, the recent analyses of fenﬂmemine required twenty
subjects only. For heroin, however, we have completed mm than
one-hundred and fifty trials in mre than seventy subjects and
methadone we now have mre than eighty
still areinunsatisfied. Forand
probably have enough for a preliminm'y
subjects
twenty
record:
analys 5.
additional problem is the rwte of ministration. We have
limited experience with drugs given by inhalation. I anticipate
that we will make many errors initially. For this reason the answers
to the questions below are approximate.
(I) How many subjects me you planning to use?
An

,

sw/W-znanz'nm'rz

Wﬂm.-lﬂﬁ"5‘7AY¢3meﬂNm79'r-T\VNY'

run:

mains-1

raw

:‘Wx‘v

(a)

POM-addicts?

(b)

Momma?

(a)

20—30,

(b)

6

-

12

fewer,

How
How

’

if

repeated

many?
many?

trials are satisfactory.

�-2-

Dr. Scigliano

(2)

September 3, 1968

Dosage
(a) Dosage to each?
(b) How my doses?

(a) Dosage to each?
1. Tm: 20 mg initially. This dose will
be increased as needed until either EEG
or behavioral effects , or both are
clearly manifest.
2.

(b)

How many

1.

2.
(3)
g
s
E

Marijuana:

'IWo

"puffs" increasing to a

full cigarette or nultiple cigarettes ,
as wmnted.

doses?

at least two trials per subject,
If the dose response
becomes of interest , probably three to
five doses for each subjects.

THC:
THC

Same

and a blank.

as

THC.

subjects to be scanned psyche/tummy
(a) Post addicts: a psychiatric examination is recozded
in each subject. Those with complicating diagnoses ,

How

Me

«the

as depressive psychosis , schizophrenia or chronic
alcoholism are excluded.

E

E
E

E

Q

(b)

E

Volunteers: Each volunteer undergoes a psychiatric
examination and evidence of psychosis is sufficient

reason for exclusion. In addition, we plan to
include only those volunteers who admit to previous
marijuana exposure in these studies. Each volunteer
also completes the MW]: which we are not investmating
as a screening device.
(4)

whet

mama will be taken to pleated: the normal vomnxeu?
present study progmm with normal volunteers provides
the basis for the trials with marijuana and THC. The
project is frankly eXplained to each suhﬁect by a
research assistant and then again at the end of the
psychiatric interview, by one of the senior scientists.
At the end of this explanation the subject is asked to
sign a permit for a research study.
The

�-3-

Dr. Scigliam

Septenber 3, 1968

After each exposure, subjects are advised
to undertake only limited activities for a
minimnn 2n hour period. We do not permit

thentodriveaoarardpayalltaxiexpenses
home
member
and all subjects
is monitored by a staff
areaskedtoretumtothe 2Hlaboratoryortobe

to and from the laboratory. Their return
visited by a staff umber

hours

after exposure.

In the event of an untoward reaction, admission

to the Psychophamacology Research

Metropolitan Hospital

Ward

of

is assured, or for

females

the private pavilion of Flower and Fifth Avenue
Hospitals is available. The principal investigator

is

m

W'v-

-.

(5)

(Um-v

psychiatrist at both institutions.
CW” 5M. the heaoin challenge studied - the due
and whethu M4119 poet-addicts and/on newt voluntew.
Heroin challenges have only been done, so far, in
post-addicts. Our usual dose is 15 - 30 mg/ch
saline/ 2 minutes intravermsly. When heroin is

Yty'rI-‘Q'Wﬂmrr’vn'x

given to subjects who are not receiving duonic
narcotic antﬁonists , we administer intravenous
naloxone (1 mg) at the end of the eaqaeriment and
give oral naloxone (2 mg) approximately 3 hours
after heroin exposure.

F,¢n-.¢u~v.—

Man-w,

..

.—

n

sea-.1

V’a-zr'"

Viva“

:v

xy-nvawvv

an attemling

(6)

a
$221be
heat £a

ace

«:0qu be

~

the dwge - both mau’juana and A9-THC
ue compounds and the passe/med Manage
l8'CC. Secwxg Ahoutd be mntained by

inch and hey.

.r:

:

&lt;t1wemvvrwmr¢smmmrmwwrr

wa'rv

,

'er-r‘

W‘s,-

Stability of the drugs: yes .

�a.

Dr. Scigliano

(7)

September 3, 1968

-l&amp;-

0554mm! owe/L 5mm: -

etc.

Letter requested (see xerox enclosed)

Sinceme yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>my”,

a-v

.

rv-uvg-nm

October 21, 1969
Dr. John A. Scigliano, Ph.D.

Executive Secretary
ad hoc Marijuana Advisory Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:
As the letter from Dr. Coy Waller indicated, the samples
of haahieh which we obtained in Athens are active but 'impure'.
His note and his comments during a visit to us suggest that
NIMH has, or may have available soon, supplies more active in
THC-A-9 and less in cannabidiola.
We are now beginning a series of better controlled studies
of the behavioral and EEG effects of marijuana (NIMH sample)
and hashish (our Athena sample). We would prefer to work with
supplies that are more 'pure', and I am writing to ask that you
keep us in mind and make supplies available to this laboratory

when

these become available.

Thank you

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                  <elementText elementTextId="105815">
                    <text>m.

wnwlnw",

m.

y

.V

&lt;

.—-

vm‘..u——- m'AWaV—w*

. .

.. l.

., ,3.

m'wm'wm—‘V—me"

m’wwr‘wmmwmz—a

u.

n lama—u ‘rrqr-“V—V—uw—I‘r'm—‘z'n-W'V-v-‘m.VT&lt;\

am...»

February 16. 1970
Dr. John A. Scigliano, Ph.D.

Consultant, Pharmaceutical Sciences
Center for Studies of Hnrcotic and ﬁrug
National Institute of Mental Health

Abuse

5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

”—7..."

Dear Dr. Scigliano:

studies of marijuana are continuing and 1 am writing
to request an additional supply. Our initial supply was from the
Our

sample NIMH-l.

Is

it

possible to request

an

additional

500 Grams?

Sincerely yours,

Professor of Psychiatry
Mszp

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                    <text>March 23, 1970

rr’.

w.

w—

Dr. John A. Sclgliano

Executive Secretary (NIﬁH)
Psychotomimetic Agents
Advisory Committee
FDA—NINE

Center for Studies of Narcotic and Drug
National Institute of Mental Health

Abuse

5454 wisconsin Avenue

Chevy Chase,

ﬁatyland 20015

Dear Dr. Scigllano:

Enclosed is a progress report of our work, a record
of the usage of marijuana, and a copy of the IRS Tax Stamp.
each.

Qur present schedule anticipates 40 experiments, 1-1.5 Grams
We would like to begin in mid—April and work
through the

summer.

If available,

may we

request

100 Grams

marijuana of

potency approximately equivalent to our present sample, VINE-l?

Sincerely yours,
Max

Pink,

”.9.

Professor of Psychiatry

MP

:kp

enc.

Tax Stamp

Progress report 3/1/70

Use

of Murijuana

�3/23/70

RECORD OF MARIJUANA USED

12/4/68
12/18/68
1/15/69
4/18/69
11/29/68
12/6/68
12/20/68
1/22/69
1/29/69

.
.

17.0
11/10/68
through 11/26/69

(1.0

1

Gm/day)

3/2/70«3/S/70 4.0
(1.0 Gm/day)

Gm

2.0

Gm

3/6—3/11/70

3/5v3/6/70
3/5/70
3/6/70
10/31/69
7/28/69

3.0

1.
1.

Gm

G

»

.0
0

�</text>
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                    <text>April l6, l970
Dr. John A. Scigllano
Confer for Sfudies of Narcofic and Drug Abuse
Mafional lnslifufo of Manfal Healfh
5454 Wisconsin Avenue
Chevy Chase, Maryland ZOGIE
Dear Dr. Sclgliano:

Enclosod are xorox copies of my lelfer of March 23, l970,
The record of nmrijuana used, fhe pregress roporf of March l970,
and a xerox of The Tax Stamp. ln addlflon, a copy of a leffer
fhaT l have jusT wrlffen +0 fhe Dlsfric+ Diracfor of Internal
Revanue requesfing fhelr cerfiflcaflon fhaf The Tax Stamp has
indeed been lssued by fhom and is nol counfarfelf is also

enclossd.

in order To accomplish The prasen? range of

studies before

summer recess lnTerferes wifh our subjects, we would like +0
begin on Monday, April 27, and i would appreciafe your earliesf
affenfion #0 our reques? for lOO Grams of marijuana.

the

Slnceroly yours,
Max

Fink,

M.D.

Professor of Psychlalry
mf:kp

encs. Tax STamp
Progress report 3/l/70
Use of MarlJuana
Letter #0 IRS

�</text>
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                    <text>July 6, 1970
Dr. John A. Scigliano
Center for Studies of Narcotic and Drug Abuse
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Dr. Scigliano:

have completed one study with the marijuana recently
supplied us and are planning to undertake two studies during
August. In one we will use marijuana left,es£ the amount left
is adequate for our needs.
We

we wish to test the marijuana extract
hand the three ampules 880 #61152 rated
have
on
distillate.
AQ-THC.
To
17.12
at
carry out this study we will need an additional
three ampules.

In a second study
We

it

would
be
few
weeks?
next

possible to obtain this supplement within the
\

For your information I am enclosing a summary of our recently
completed marijuana experiment as well as a record of our drug use.
Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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‘avwrw;plrw“v&gt;r’awm,‘~—Vm

Dr. John A. Scigliano

.
w

Executive Secretary
Psychotomimetic Agents
Advisory Committee
Center fro Studies of Narcotic and
FDAwNIMH

Drug Abuse

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, ﬂaryland 20015

Dear John,
A

is A Grams. 0f the original 3 Grams
(ll~4*69) we used one ampule in pilot trials last coring, and a second
ampule this November~Dccember. We have one ampule (l Gm) left and
3 ampules of the batch of 7-10-70.
We will use one additional ampule
in pilot trials these next few weeks.
Our

&lt;-&lt;

raw-"mm...

.W'rr-‘c-"w-ﬂwv:

warm-w

MED

For our proposed study we wish to assay 20 subjects at each of
doses, for a direct use of 1400 mg THC. Since we have a 10-15%
dropout rate (inco'plete trials) we anticipate the need for 1600 mg
THC. Hence, our request for 10 additional ampules, to complete tho
study and provide 3 ampules for additional trials and/or errors in use.

Sincerely yours,
Max

Fink , Nun .

Professor of Psychiatry

l...

'q

present balance of

3

—

—r-_~‘1-4v-',

progress report of the recently completed study is enclosed.

MF:kt

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                    <text>January 8, 1971
Dr. John Schinel
£0 Granercy Park N.
New York. New York 10010
Dear Jack,
Enclosed is a revised version of "Toward a Rational Theory
of Behavior" for Career Directions. I have made the deletions
suggested by the editor, and almost all the changes in text which
I could. I hape this ”compromise" is satisfactory.

In re~reading the text, perhaps it may be useful to add the
citations as sources where the observations are reported in more

detail.

My

thanks for your cooperation.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kt

enc.
cc: Freed Scheel

0.3. Publications
299 Park Ave.

New

York, N.Y. 10017

�</text>
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                    <text>i

v

,
m

August 20, 1987
Dr. Allan Scott
Department of Psychiatry

Royal Edinburgh Hospital
Morningside Park
Edinburgh EH10 5HF
United Kingdom
Dear Dr. Scott,

"'Ivn

"tum-WI

‘T'V‘WVLWFNTW""W"’VW_"F!""=V"

(Following your call, we made reservations for you and your wife at the
Three Village inn in Stony Brook, N.Y. for late arrival on Saturday, September 19,
and departure on Tuesday, September 22. The room is a double, with one bed. The
charge is $75 to $95/night, depending on the location. (Inn: 516-751 0555).

Kennedy Airport is about 55 miles from Stony Brook. The principal
connection is by airport limousine. If you let us know your flight number and arrival
time, we can arrange for either Winston Limousine (516-589-3938)or Colonial Taxi
(516-589 7878 or 800-645 7878) to pick you up. if we arrange a limousine, you will
call the appropriate number on arrival and they will tell you where to find the car.
The rate is about $35. Do not take a regular taxi —- the meter rate is excessive. if
you are in trouble, call us from the airport (516- $2 6651).

V1"'WI""'~“"N"WVW

~
-

mw-cw-ﬂ-wv'w—v

‘

We plan to be at home (about 7 miles from the Inn) that week-end, as I am
'on call' at University Hospital. You will be welcome to join us Sunday afternoon or
evening, according to your jet-lag. i will plan to pick you up at the inn on Monday
morning at 0715; I will be treating patients with ECT at 0800 that morning, and
making patient rounds later in the morning. You are welcome to join in. After
rounds, approximately noon, 1 will be free to work with you.

Stony Brook, and the associated villages of Setauket and Old Field, are
quaint Old English villages, with a strong association with Long island Sound. There
are museums and old houses in the villages. A neighboring village is Port Jefferson,
which is a major port. A trip East along the North Fork will bring you to the
wineries and farms. A trip to the south will bring you to the Hamptons and Montauk
-- the ‘in' communities for the yuppies, the rich, and the famous around here. Or,
directly south is Fire Island and Jones Beach -- among the finest beaches in the
world. Bring bathing suits and boating shoes.
Have a good trip West.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�.
.
m...“

_.-

February 9, 1987
&lt;w..-,,.W——w«

—.,

W—wrv

vv'Vll‘F'r'mr'v-W»

Dr. Allan Scott.
Department of Psychiatry
Royal Edinburgh Hospital
Morningside Park
Edinburgh EHlO 5H1”
United Kingdom
Dear Dr. Scott,

at Stony Brook later this year.
end
the first Monday in September. A visit anytime
Summer holidays traditionally
after mid-September should be convenient.
We will be pleased to have you visit us

I

University Hospital is about 60 miles from mid-Manhattan. it is usually
more convenient to stay at one of our local inns; the Three Village inn (Main
Street, Stony Brook, New York 11790) is most favored.
Our present interest is in two projects -- the efﬁcacy of ECT in therapy
resistant psychosis with an associated study of prolactin metabolism; and the
el-ectrophysioiogy o1 induced seizures. For the latter, we are re-examining the
relationship between the seizure EEG’and the efficacy of seizures; and between the
inter-seizure EEG and clinical outcome. We have completed a study of DST and
outcome in ECT, with disappointing results.
‘

.Your studies of ECT are indeed of interest to us, and i look forward to
reading the results of your studies. As you may know, i launched the journal
CONVULSIVE THERAPY in 1985. We are in our third year and i am quite pleased
with the quality of the material which we are receiving. You may wish to consider
the journal for the publication of reports from your studies.
Oswald.

We look forward to welcoming you in New York. My best regards
I

Sincerely yours,

Max Fink, M.D.

.

Professor of Psychiatry

to [an

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                    <text>c“

&gt;=W1"\W“DX.\YV

-._-.V_._..,u.~;—v.,.

m... ...,. 7-“

,

1/ra”... _M u, a........,:w-wyn: .—
a

he?

m.V‘!-'-c“:v.‘rw—

November 12, 1970
Miss Bernice Scott
New York State Narcotic Addiction
Control Commission
1855 Broadway
New York, ﬂew York 10023
Dear Miss

Scott:

pleased to enclose our report "Treatment of Heroin
Dependence with Opiate Antagonists" which appeared in Current
Psychiatric Therapies.

I

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc. (5)

�</text>
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                    <text>Ayuwa

..--

..

.vyv-

Octobar 8, 1970

"m

‘.
v-

_._.—r--,

.2JWW‘

arm,

WW,"

Miss B. Scott
Now York State Narcotic Addiction
Control Commission
1855 Broadway
New York, Now York 10025
Dear Miss

Scott:

Enclosed are the summaries of the meeting on narcotic
antagonists of June 4, as published in Science.

I wan. to thank the

support.

Commission

for their interest

and

Sincarlly yours,
Max

Fink, M.D.

Profesoor of Psychiatry

Hrzkt

�</text>
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                    <text>W1» 2, 1963

Dr.

J.

The

Hospital

C.

Scott

Multan: Paydaiamst

Perthhim
My,
300th

Burr». Seott:

mm.
for a position at this Imtitute as an m; Reewdist.

806th
Gum,
emdlwouldapmShehnsubmitudymrmvasamfm,
infmntien regarding her personality. hm
date moaiving
Miss Ame Welsh

has applied

any

of

n Dryburgh

ability to participate: in manna with mar-ham, and the potentialities for
a clinical

Wat
my

Thank you

W.

mat for yam cooperatim.
Sﬁauaembv yams.

Fink.
Dime'tor

Max

MFxmlg

Pl. D.

�</text>
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'I'J-I-cm

mwr

Mhrch 22, 1971
wwrnwrmw-wvvq—wv

Dr. Barrett Scoville
Deputy Director

»~'

~'

"a,”

Division of Neuropharmacologicel

1

W

N

W

nu.

n
&lt;.

,nm

Drug Products

Office of Scientific Evaluation
Bureau of Drugs
Rockville, Maryland 20852

”VP”

Dear Dr.
nag—.7-

v'vw'"

,7

:r-

«war-rmraww—x-y-gwmwg

.-.V

:uvmmvmew"

-.—v-

-n—m

www-

Scoville:

RE:

IND

6825

Methadone is obtained from the pharmacy at Metropolitan Hospital,
York City in liquid form. The appropriate dosage is measured by
trained (R.N.) nurses and dispensed to patients diluted with grenadine
syrup. Each day's dosage is dispensed separately; patients coming to
the clinic 5x, 4x, 3x, 2x a week.

New

For £*a~acetylmethadol, we have received pure powder foam Merck,
Sharpe and Dohme Research Laboratories, West Point. Pennsylvania 19486.
This is measured cut by the licensed pharmacist at Metropolitan Hospital;
dissolved in grenadine syrup; and dispensed 3x/week. Dispeneation by the
same

trained

R.N. personnel of the methadone

unit.

Sincerely yours,

.

Fink, NJ).
Professor of Psychiatry

Max

�</text>
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                    <text>unnumwm

.

.

_,.

"v

.r.yr~‘w~mw«

May

11, 1971

Dr. Barrett Scoville
Deputy Director

Division of Neuropharmacological
Drug Products

Office of Scientific Evaluation
Bureau

of

Drugs

Rockville, Maryland 20852
Dear Dr.
The

which

Scoville:

RE:

IND

6825

curriculum vitae: of the investigators are enclosed.

is prepared by the MetrOpolitan Hospital pharmacy,
is staffed by licensed pharmacists.
Methadone in solution is obtained from the pharmacy by our

Methadone

nurse. and then kept in a locked wall closet, in a locked room,
until dispensed. Supplies for 2 days at a time only are kept on
the unit.
Urines are collected from patients one at a time by a male

aide (psychiatric assistant).

We are using methadone as a comparison for L—alpha-acetylnethadol;
and the filed protocol is the only operational protocol at present.
At an earlier time, methadone was the standard for cyclazocine and

that protocol was filed with Sterling Winthrop, for submission under
their IND for cyclazocine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>wx-

~n,
~

me

"4““:

October 14, 1971

#"W~,

W‘Ac:

‘71.:-

7-7.0

Dr.
FDA

Barrett Scoville,

M.D.

Rockville, Maryland
Dear

Barrett,
I

am

writing in reply to your request for information

from our study of l-alpha-acetylmethadol (IND 6590).

are completing the data analysis for the two
groups of patients, 10 each, who received methadone (100 mg daily)
or l-alpha~acety1methsdol (Bx/wk). Three of the patients are
now completing their 4th month of treatment, and our evaluation
period extends for 6 months in each case.
We

initial

it

is clear, however, that
l—alpha-acetylmethadol is equivalent in every way on a 3xlweek
schedule to methadone-w in patient acceptance, staff awareness,
urine test results, duration of antagonism (cross tolerance) to
injected heroin, and drop out rates. Indeed, I am impressed with
the data, and have asked my associates to complete a preliminary
report for your use, as I believe that further testing of this
drug is warranted, both in the maintenance of patients, and during
the ambulatory withdrawal schedules now actively used in my city.
From

the

I believe

Committee and/or
My

group,

you should

SAODAP

alert the

Methadone Advisory

that such data is available shortly.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

difference in our recent results from earlier published
results is in the dosage schedule of 70-70—80 mg.

P.S.

The

�</text>
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                    <text>Novsubsr 16. 1971

Barrett Scovills,
Deputy Director

M.D.

Department of Health, Education
&amp; Welfare
Food 5 Drug Administration
Rockville, Maryland 20852

Dear Dr. Sioville:

studios under

Vs
IND

progress report.

hsvs conplsted the snclossd summary of
4724, and are submitting this cepy so our

Sine-rely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mrzig

�</text>
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                    <text>1-.

'

y...

»-

svaC‘ﬁ‘

.

-_

mum-n. »_v-.v.mzuv--

is
W
'1“ MI. 3"
n13.1314-

g

V

":5

_,

August 22. 1973

K1113. Hons

hospital

YO“

Durban.
I hm sosd tho outliuo of tho smootod pron-so for tho
sad not for so oxcollont formation.
sposkoto. you hm thou-mod tho
s
stroy

.

sud wish to mootulsto you
ms hosting, such
£o'tuidsblo
of

ly dmlopiua
lootwot sad as to

Roch

costs up with

«nothing of oquolly tins qus‘lity.

to spooitios. 8.1m mom is prosontin: on tho
dismount to: Labor-sky sud Prod: should ho Lovitt. I would
to mass his “potion“ so ho dooos
and»: ho
soproprists, olthough ho could to on woolloot oltsmts choimu for tho
As

second dsy. tho
concur thot Boy

mom

first action.

You osy out to couoidst moths Shogsos so o discussont of tho
hoh-stiot thotsuy nation 1! Joins Frank is not sscoudsd. masons hos so
sctivs iotot‘sot in this thstspy sud hos misusd tho dsto wtonsiuoly.
'

'

sddooss should
tho Koch sword

tho troditiou of tho

Foch «std sud tho Possidsotisl
sud hsvius one ooch dsy is sstisfsctory. with
also no tho
sword, sud this osy «quits o too oars oinutso.

to stintsiuod,

will

V

rum

For moons of history, it would ho us'oful if so could inoludo
Exits Payton. ”shops so s couchsirosu o! coo of tho sossions.

I

would oucoursxo you

to {cmlsto this prom-so so

occsptsd, soot-sins tho othot woos oi tho Council moo. sud you writs to
tho invitod portioipsnts tor so abstract. Should thoso ho svsilshlo by was
sod of
or only Octobor. to soy yo: ho shlo to host tho usual
rush for tho dosdlino of tho Journal.

not“:

My

thanks for on

woollsnt job.

diatom, you-rs.
Koo

to.

30 Colo
R

Spits“

Fink.

24.1).

�</text>
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                    <text>a

V-‘“

~V’

'-

arr-1r.

--r_v-x~wxmw.-v

mm

w

7383.83988
20 December 1973

Dr. Alexander Levine
Chairman of the anberehip Division
and Fellowship

Anericen Psychiatric Association
1700 Eighteenth

washington, D.C.

Street,

H.w.

Dear Dr. Levine:

I

Dermen

am

pleased to

recommend

to Fbllowahip in the

the promotion or Dr. Robert M.
Psychiatric Association.

American

I have known Dr. Derman fbr more than two years, first
in his role as Chief of the Addiction Service It the Manhattan
Veterans Administration and lately as Associate Professor in
this Department. During the past year I have worked closely
with him on e number or academic essignmente. In these relationships, I have elwnye found him to be friendly, modest, reliable,
and innovative. an accepts responsibility and he: carried out
the missions of the Department admirebly. He in e well-qualified payehietriet with extensive clinical and administrative
experience. In his present position, he is actively involved

with community education.

vw—x-

‘vzu-

v:
-

I am.pleeeed to recommena him for Fellowship, for I believe that he has already demonstrated the attributes of this

honor.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

:W—"mmwmw

EARA,

1951

President, Nassau (N.Y.)

District Branch,
MF/cis

1959

�</text>
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                    <text>vv'

any-ya."

or
n

73AP~767AP

'wwmm-W‘

-

-

NW?

16 Rovodbot 1973

‘W-xr‘

'm‘.

(ﬁn-m»

Jonathan 0. Coin, M.D., Secretary
Anorioan Psychopathologicol Aaaociation, Inc.
Tomplo

Univoraity

Philadelphia, Pennsylvania 19122
'W‘W'WMMW

Baa: Jon:
Tho minutes are ooaantially correct. Since Lowrance Kulia
has died. I have delotol our raconmandation from tho paragraph
on Page 1.

“MEIER"?

Wm

1

Wmm’m’

I have

aakod Fritz Froihon to that: and Joe Zubin and Sam
be
on the Nominating Committaa for 197&amp;. This amendto
ho
addad to tho minutes of Octobar 15. I agree that
uoot might
both Milt Grocnblatt and Mt. Goollnor bo invitad to tho March 6
Council looting. Invitations to Spitacz and Freihan also would
be appropriate.
Guaa

I am also enclosing a copy of a letter that I hava received
from aux: Grenoblatt following our diacuoaion of tho Roch award.
beliovo the latter to self—explanatory and supports tho Com~

Inittaa'a
‘7‘»?

.ieuzwrmﬂwmmﬂwwmm

rocounandation.

Thank you for your help with tho ACNP invitation. I was
able to clear tho invitation for Dr. Van Riozon with Dick on
tho balls that Van Elston to a Iotaisn pharmacologiot. I trout
you will havo a chance to coat his in California. Ho hawo a
date with Lyla Hillar for Novoﬁbor 27.

Sinearely yours,
:4"

ﬁsh:

Hhx

n—xmra

H
95“

at
77-22).?

...v.

ﬁllets

Ennis.

Fink, H.D.

�</text>
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                    <text>February 8, 1980

Barrett Scovillo,

M.D.

HINCDS

Bethesda, Maryland
Dear

Barrett,

Thank you for the articles on barbiturate withdrawal. I raised
tho question in answer to the suggestion, made by Dr. Tyrer, that misnserin
may have epileptogonic features. His case report was flawed, however, by
the fact that the patient had had lorszepsm withdrawn two days before
the seizure.

In the recent issue of Lancet (January 19, 1980, p.151), Einsrson
four
cases of withdrawal seizures with bansodissepines in one year.
reports
Dr. Tyror’s response is also included.

It is clear

the paucity of literature and the persistence
of the question of bensodiszopine withdrawal seizures that systematic
studies in man need to be done.
from

Insidentally, I had dinner a few nights ago with Dr. John
Davis of ColuMbus, Ohio, who remarked on your work and some association
with him. I thund him most pleasant and particularly knowledgeable about
FDA and drug regulatory matters.
My

regards and

my

thanks.
Sincerely ydurs,
Fink, M.D.
Professor of Psychiatry
M3:

�</text>
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                  <elementText elementTextId="100961">
                    <text>Manet 20, 1968
Dr.

J. Mhuz‘

Seaholm

A. H. Robins Oanpeny,
1&amp;0? timings naive

MW 20,

Virginia

m. Seeholm

Deer

Inc.

Way

In June. the
Mitten of the Missoxmi Institute
of Psychiatry approved a pilot study of butepemine dimeleete and
the etetmnt of investigators were filed with your office by m.

Thdeeignheemtbemcrmgedendtm studyisin
mun.
I
have,
women.
We“. suggested that a etetment is
new

not necessary.

Asymmm.thedeteiledstudyofemdmg.beyom

mm

minimal clinical obeervatimo, entails extensive
keeping
and examinations of a specialized nature. At the present time,

information. lathe
mmmvidemlyﬂnminimnelinicel
event that you have em interest in acme detailed investigations,

Imldmgeetthetyouvieitenddimsﬂneewithus.

arm

Sincerely

yam .

Fink,
m
Director

M.

D.

�</text>
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                    <text>Septenﬁnr 30, 1983

Arthur Seaholm
‘A. H. Robins
1&amp;0? Gunning: Dr ve
11-.

'

mm 20, Virginia
m swam:
Dr.

have received 288 pints Elixir Butapwmim and 2n
berths with 100 capsules each of Bumper-axing.
We

thank you vary mah.

Simmly yam,
Fink, H.
m
Directw

D:

�</text>
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                    <text>‘r

,-

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WW

A. H. Robim

Many.
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WWW.

15 , 1963

D.

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we began

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am, in 1&amp;an chronically $.11 psychotic subjects.
Wealsohavohadaeoupariammml armpofthjm.
months

thawonemdmimtingeffmmdwwldlikoto

mimethisstudyinalwgarmofpatienm,includinam
Woulditbepmsiblctoobtainmadditiaalmpmmjocu.
ply ofbutapemzine? The mtnoededia «on pints of 011m

humming.
M.

Ourxmentwyplywinboemudmw

In the evant that you wish my traditional infant-1m,

wwldhcplemodtolnvaywvisitwiﬁzua.

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                    <text>November 29 , 1965
‘

tester Sebastian

Mr.

Chief ,

szts

Managemt and
Audit Review Section
Grants Management Brandi
Division of Research Grants

National Institutes of Health
Bethesda, Maryland 2001!;

Attention:
Dear Mr.

Todel C. Ball

RE: m;08597~01

Sebatim:

is the Final Report of Bxpmditurea for Public
Health Senda- grant iii—0859741. The last bills for books
and equipment bought mder the grant was submitted and paid
Enclosed

mmingﬁmmthofwtober. miewas oooasimedbyﬂwfeot,
that equipment ordered one year earlier was not delivered sinoe
a mufactmer in Englmd had difficulty in pmduotim. It
was decidedtohawrthie orderinsofaraa theequiwmtwas
necessary for the studies which, while terminated at the
Foundation, have been omtinued in tmnsfer at the University
of Missouri in the

em

location.

left this Institution and
this final reporthaenotbomapprovedbyhim. However. the
pmliminarympoxtwaeeimedbyhimandﬂmmamnochangeo
'

In the interim Dr. Gerohon has

fmthatreport.

.

In addition to this final report on 08597, we are taking
this opportmity to file final expenditure reports on training
grate 8388 md 8%». The deficits noted on both these
tmininggrmtearerelatedtoanemrinohargingﬁxegrmt
and in paying social aecamity taxes. We have requested the
Internal Revenue Service to mimbme the Pomdation for the

manta so expended.
I twat that these are satisfactory.

Sincerely yours ,
Fink, M.D.
Executive Director

Max

MF:kp

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                    <text>May

12, 1971

Dr. Steven Secunda

Depression Section
Clinical Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Dr. Secunda:
With reference

to your letter of April 29,

I

find that the

quotations are accurate, and are not quoted out of context.
may quote these for the Director of the Institute.

You

we have recently presented the results
patients treated with MBCT, and I regret to say

For your information,

of our

first

34

have not achieved a "dramatic" reduction in improvement.
most puzzling and we are continuing our studies to understand why MECT acts like single induced seizures.

that

This

we

is

Our studies clearly support the data that unilateral non-dominant
electrode placement produces clinical improvement in depressive
illness with minimal or no memory deficit, even in elderly patients.

I

trust these

comments

are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

_

-,.

s

.

�</text>
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                    <text>~

~wm-n-.v.mwvm"‘m-Wssmw may...

. “0.:

.m:mu.-, .‘wuyn—Ig J‘JI'WC'mmm-

.

-

,

7

May

u

g

,

.vur y'arth-‘g-Wg ;7~‘,.‘..W,»Wmlmn,— rvvv-v

4, i970

Dr. Maurice Seevers
Univarslfy of Michigan
Deparimeni of Pharmacology
Ann Arbor, Michigan
Dear Dr. Seevers:
in a leflar from Dr. G. F. Blane of Reckiff and Colman
describing sfudles wifh narcoilc anfagonlsfs, he menflons
320*M as an inferesilng cempound 3? Michigan Unlversiiy which
failed “To prolacf dapandenf monkeys againsf sympfoms of
morphine wlfhdrawai”. i presume the work comes from your
laboratory and would appraciafe your raferring This nofe +0
fhe appropriafe co-worker for any pre~prin+s Thai may be

available.
Many

+hanks.

Sincerely yours,
Max

Fink, ”.0.

Professor of Psychiairy
MF:kp

-x-.-—_

'.-‘:V

-

‘ni‘Vm‘mﬂ‘m'n

~

,
-..;,-

'v‘

u:.~muu.;.~—~,,vvy—«ww‘w-m.w:mmgmmvw

.v

,

.,.

.

�</text>
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                  <elementText elementTextId="101166">
                    <text>December 23 , 1963

J.

P. Segundo
Brain Research Institute
U.C.L.A. radical CenterLoe Angeles 2», California
Dr.

mar

Dx‘.

,

Ssgundo:

of the
I amwriting at the: amnion of Dr. 6. Sierra who
has
Dapartmnt of mum of the mivemity at Navm, Spain,
applied for a position at the Missouri Institute of Paydxiatry. Dr.
Slam has indicated that he would like to join tbs Imtitute in the
positim of a Research Scientist in Neumptwsiolom.

program. and
mew
has develowd laboratoriaa in electmanaephalmhy. mater sciences ,
The 1:131:11:th has an

active clinical

the present tim, them is no pmgram
in experimntal mumphysiolow mick of clinical mseandm prom.
I would be mteful for your moaamndatim regarding Dr.
and especially
ability as a
Siam, his personality, his
any sugmstims regarding his ability to maintain an indepedent m~

phanmcolow, and pawl-50103;.

At

Mr

search program.

have recently established a close relationship with the
amputer canter of Washington adversity and a major effort is the
We

application of

tactmiques to the analysis of the
digtal Wear
would be
for any infmmatim regard-

I
electmenmphalowu
"
in
Dr.
1mm:
ing
ﬁlm's

grateful

such applications as mflacmd

in

any

�Ir. J.

P. Segmdo

December 23, 1963
Page Two

Thank yen very much

for your momdatims.
Sihcamly yours,
Max

Fink,

Director

H. 1),

�</text>
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                    <text>November 18, 1969

Ex. Kaith Sehnert
COMEED

Rockvilla, Maryland
Dear Keith,

It

was kind of you

:your new position and the

opportunity.

ta sand me tha informaticn about
activities of COEMED. It sounds like a fine

Our own work has prograssed well. The EEG analysts that
projected in 1965 as a technique for the evaluation and classification
of psychotropic drugs in mag is now an oparntionnl technique. we have
rec¢nt1y classified doxcpin; previously ideptlfied the sedative propertiaa
of fenfluramine and the antidepressant qualitiea.of cvclanocine; and
are now busy identifying three navel comveunds for three different firms.
The same techniques are also under gaudy by my associate, Dr. 1:11 in
St. LQuis and he has some similar data with other compeunda.

we

I believe thg techniguaa are now at the stage where they
generally. It may he of interast to you and your
assaciates to visit our lateratory and observe the processes in operation.
can be applied more

-

to your

Again, my best wishes for your auccaaa; and I look forward
your convenience.

visit at

Sincerely yours,

Professor of Psychiatry
mil

�</text>
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                    <text>June 18 , 1965

Dr. Keith

w.

Semen:

Assistant Hedical Director
Dorsey laboratories
Lincoln, Nebraska

Dear Dr. Sel'nert:
have just been able to make the necessary pmvisiaw to
mdertahe the study of pymvalerme. It will be in progress by
middle of July and we would be pleased to have you visit
with us. Both Dr. 11:11 and I expect to be in St. Innis during
that week. In general, Mondays and Fridays am difficult days
for us. We would be pleased to meet with you on Tuesday, Wednesday
or Tmrsday. If you muld let us know what day you are planning
to visit, we will be glad to have lunch with you.
We

tn

make

Incidentally,

would be

drug.

Dr. Pogge

indicated that he might

interested in any

be able

Sincerely yours,
Max

Fink,

H.D.

meesaor of Psychiatry

Mfdcp

to

If this is so, we
infatuation that is available on this

dibanzothiazepine available for study.

�</text>
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                    <text>July 12,

1955

Dr. Keith H. Selmert
Assistant Medical Director
Dorsey Labomtories
Lincoln, Nebraska
Dear Dr. Sebnert:

to having you visit us on Wednesday and
suggest that you come to the laboratory about 10: 30. We have
a case conference from 9:00 am to about 10:30 am every Wednesday
morning. You are welcome to join us at 9:00 if you like. We
would be pleased to have you audit one of our cases.
I believe we can complete our discussion in tine for you
to leave at 2:15. We look forward to having you visit us.
We

look forward

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>A

.

Irww'h'

Dacanber 26th, 1972

wr.u7§"w

M?.'Gary Seidler, Editor,
Addiction Research Foundation of Ontario.
33

Rusaell Street,

Tbrento 179, Ontario.
Daar Kr.

ﬁeidler,

I have been receiving Ike Journal for the past few
at the ﬂaw York Madical

months at my pwevioua addrasu
0011333. I find year rayorts

of tn» arug scene excallant.

interesting

and the coverage

I wenld appreaiate continuation of the subscription

u
c-.

addressed to:

‘

Max

i
n

Fink,

M.D.

Dapartment of Psynhiatry,

p

fE

Health geisncan Center,
Stata University of ﬂew York at Stony Brook,

i‘

?

Stony Brook. 3.1. 11790.

Sincerely yours,

th

Fink, M.D.
Frofessor of Psychiatry
MF/iﬁ

�</text>
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                    <text>H.

r-..

.

mu, .M was» m'so-

tw-‘rrVrv-n www.c—

-.x pm,

-0"va w-ur—a «n mwrw-

em“. a-.- -w'

w.

..-.VV._:....

,.

“kw".

. a

Jun—-m—ns.

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PW
February 13, 1976
Mr. Gary Seidler
Editor, The Journal

Addiction Research Foundation
33 Russell Street
Toronto, Canada
Dear Mr.

Seidler,

For a number of years, I have subscribed to the
During
this time, I have watched the scientific quality of
Journal.

the reports deteriorate, with the report by Ms. MacLennan, describing
an interview with Dr. Eugene LeBlanc, the latest low point for opinion
without evidence.
At no point in the report is there any data presented. One
tell if Dr. LeBlanc is a researcher, admonisher, or administrator;
and if he is a researcher, I cannot find a clue as to the type of
work that he does which Justifies his opinions.

cannot

It is sad that the newspaper of a research organization
serves to print opinions without basis in fact. The issues regarding
cannabis are controversial, and we seem to need more light and less
heat. I wonder if your office will try to report the transactions
of the recent chronic cannabis use conference in New York; or the
results of the Greek study of Stefania and Dornbush (a copy was
sent to the Foundation last summer ); or the 197% meeting sponsored

by NIDA on cannabis

?

I fear I shall not find out, for I
to
subscription
lapse. I am disappointed.

have allowed

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

rwww

�</text>
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                    <text>north 26. 1968
Dr. Joseph Soiftor
Research Professor of Pharmacology
Dept. Coordinator of graduate Program
How York Medical College.
new York. "on York 10029
_

Door Dr.

Soiftor:

I have reviewed your request

to April

ll.

for lecturos

from April

l

.

It is difficult to undertake this mission at such short
notice since I will bo‘augy part of the time. The principal
other memter of the Department able to carry out this series
is-Dr. Herman c. 8. Dunbar. who can be reached at ﬂoohattan
-

Stoto Hospital.

Enclosed is o-list of the seminars now in progress in
(tho Department. .Porhaps those loctures, espociolly those

presented by the invitod speakers would be of interest to
the students. It is probable that those seminars will be
holo again in l969 and perhaps the noxt class of students
can be scheduled to ottond than at that time; or. we can
arrangt a special series for the graduate studonts.
Sincoraiy yours.
ﬂax Fink, M.D.
’Profossor of Psychiatry

ﬁfzkp

bet: 9r. Froeéaln

�</text>
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                    <text>March 26. l968

Dr. Joseph Seifter
Research Professor of Pharmacology
Dept. Coordinator of Sraduate Program
new York Medical College

New

York. New York l0029

Dear Dr.

Seifter:

I have reviewed

to April

ll.

your request for lectures from April l

It is difficult to undertake this mission at such short
notice since 1 will be away part of the time. The principal
other neuter of the Department able to carry out this series
is

Dr. Herman C. B. Oenber, who can be reached

State Hospital.

at

Manhattan

Enclosed is a list of the seminars now in progress in
the Department. Perhaps these lectures. especially those
presented by the invited speakers would be of interest to
the students. It is probable that these seminars will be
held again in l969 and perhaps the next class of students
can be scheduled to attend then at that time; or. we can
arrange a special series for the graduate students.

Sincerely yourS.
Fink, M.D.
Professor of Psychiatry

Hex

Nszp
bcc:

0r.

Freedman

�</text>
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                    <text>19 March 1974

Isaac Marks,

M.D.

Institute of Psychiotty
do Groupigoy Park
Dcnmork,ﬂill
London 8E5 8A3
EEGLARD

Door Dr. Marks:

First, lot no thank you for your participation in the APPA
settings. You: contribution was vary helpful, and I trout that

you cnjoyod tho ocooiana as ouch on

I did.

I havo rcod the proposed rosoaroh program untitled

youtio Studio: of Booiotant Noutoooo."

"Thora~

yroposcl is an ambitious one and should make significant
contributions to the trootmont of thooc complex problems. From
the point of vicw of poychoohormccology, I can one no inherent
rationale for tho study of clooiprooioo. From the evident: avail~
oblo to no, this is on octivo thymolcptio, prdbably indistinguishable
from imipranino. Tho study will doiino tho efficacy of this
compound and will soroly juotify the invoatuont.
The

the point of viow of nouroohyaioioay, I bcliovo that
in a much stronger position to dofioc tho rolo of
the pharmacologic ngoot in tho trootooot process if you could
specify that brain changooudid or did not occur, the dcgrco to
which tho changoo wore contained, and tho relation to tho troutuont couroo. A: I iodicatod in my lecture, I bcliovo that thorn
in a good tolationohip botwooo bohaviorol changos and nouro~
physiologic offooto in ECT, and with psychoactiVo drugo. Should
you be able to racetd EEG signals in a oyotoootic way, undo:
roooonobly woll—controllod conditions, your cloctrooocophologrophor could quantity tho EEG ohangoo and provide you with an
indopoodout nocouro of drug affect.
From

you would ha

-1-

�rm-

«-..-v

Ava“):

wwmrr

I. Markl‘

19 Match 1974

~2~

M.D.

Should you not have facilitias available at Denmark Hill,
wuuld be glad to coopnrata and provida you with quantifina~
tion of tapes; if these are «ollncaad in a ayatcnatic way. under
canditiana which permit us ca nuke tho measuranant. To c01ldborata with this laboratory would regatta thnt you havu a tape
system cangntible with aura, amplifinrs which era of ransonnbly
high.qua11ty, and a teghniciun who undnrutanda eh. presentation‘
of 339 data for quantitativu mcaaurcunnt. Thar: axe rwo technicians in tha Landon urea and, dhauld.you be intotcntad, I can
string: to: your technician to be superviaod by cithcr of those
um

units which

new

at: caapnratins with us.

During uh: pat: year, I have bacon: particularly interested
Eh.
in
psychoactiva.prapert1us of a tttraeyclic campaund. nianu
auxin (GB-94), praaucad by H. V. Orguuon in Holland.' We bilieva

that niunnariﬁ is

rapidly aetivn than anitriptyliue, with
fiﬂit scdntivu tad taxicholincrgic effects. Should you be intaraatod in alias this compound.rlthcr’thtn annthar in your emu
periunnt, I would be.gind»£o propose to the pharmneoloxistn at
mere

Orgauen that they canaider providing you with such equipnnnc as
gay bu unctul far a cbllabaraciaa.

I

hopu ynur weak;

.My

best rugsrds,

in Israel are fruitful.
,

Sincerely yours,
Max

rink,

M.D.

_

Ptofcsnnr of Psychiatry
Mr/cia
Baal.

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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              <elementText elementTextId="99866">
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                  <elementText elementTextId="100975">
                    <text>August 26; 1963
Dr. B. A. Semﬂ’cinidu

my'smsley Nemmgiaal unit

The Memdsley Hospital
Denmark

Hill

London, 8.11. 5, England
Dear Dr.

Smfetinidem

Professar Irim has with“ to Ir. George
of the Division of Mental Diseases of
regarding an oyportmity with Dr. mm.-

A.

mm,

mutt.

the!

Dinner

matting infomtion

m. Ulett ammdamwpositionayearandahalfagoasmmcm‘
of the Division of Mental Diseases of the State of Missouri. At that

wuisat
timhecmamdamwmamharﬂtminingcenterinsn
Louis
This

oenter is dammed in great»
Stat. Hospital.
detail in the enclosed descriptm
I recollect mating you (having my visit last Septamber to Professor
A1: ﬂat time, I had no idea that you wig“: be interested
Maison.
in
to the States.

the St.

W

We have establism laboratories in elmoemephalogmphy, pharmacology,
and a macamh computer mnter. Er. 'I‘tm Itil joimd my staff in March
ﬁrm the Univemity of Flt-lam. Hi3 inmmat in EEG and mm psycho-

phumlogy mimidawithmyown. andmgethormmdewtingamjor
patina of the labommries' entrain to this type of work.
.

Last winter,

Hargerison visited us at 5 than when we were
mem
Imul.dboplcaudu tohaveyoudismsmoppwtuni.-

stilliﬂmmiw.
th‘
tea
Ifymmirrtmstedinjoiningaunitsmhuthis,lshouldbo
gmtaful for a copy of your amicuhm vita, as wall as a candid letter
mgmimemsmdmitimsinmmingtothesmus.
Simeraly yours,
Max

Khan
10:10.

Fink,

Dimetor

M.

D.

�</text>
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                    <text>October 1'3, 1963

Semfetinides, M.
Institute of Psyd'xiatry

E. A.

1').

Hospital
Why
Hill

“me
Denmark

Landon S. E. 5. England

Dear Dr. Semfetinides:
an
not
be suitable to 37mm

we do

11‘th
ina

latter.
‘mankymwrymfwmmmnt
have
opening available at the present tine that would

mtmnt

taunts. the institute already

in omﬁeal neurophysiology.

I haw

has

of 65.3mm your interest
Mm,
unmlabamtoriea smiah may have

taken the liberty,
with two
in coming toms
an interest in your program.

mm

35.110:me yours.

Max

Mf‘mlg

W

Pixie,

M.

D.

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                    <text>September 2h, 197h

Mr. Berton Roueehe
The New Yorker
2h west h3rd Street
New York, N. Y.

Dear Mr. gouache:

are sure to write about your article, "As Empty as Eve”,
to sympathise with Mrs. Parker and to praise your presentation. Some
will write to criticize the errors of fact and of experience. I am
writing to express my sadness that you have chosen the public press
to air a single medical case report, without the leavening of
clinical experience, which would permit this case to he ’eeen in the
context of the goals, successess and failures of this therapy. I do
not understand what service you uere attempting to offer, but surely you
.ghaVe added.your powerful voice to the many who fear that vh1ch they do
I_not Understand, thus making_it more difficult for patient 5 Who may be
helped to receive treatment.- YQn are encouraging many patients to
I.veehs and months of the unnecessary hell of a severe depression; and
even some to a suicide that may have been prevented.
Many

_

‘

'

I am sad that the New Yorker and particularly you. with your
a.record of fine writing, have choSen this topic to attack.. It is easy
easy to damn
"to find the single case which hes not done veil; it
'vith innuendo, error, misquotation, and selective quotation,balance
it is hard
to stay one' a voice when we are ignorant, and to speak with
~

is

V

when we have an urge

to speak.

Some specifics. Free the record given, it is probable that
_.
curs. Parker was a poor choice for this therapy. I anticipate that she
is a person who is critical in her perception of her environment —- in
:.psychological terns, she has a low California F-Scale, makes few errors
c;on figure-ground tests, and is unusually accurate in the perception of
*the visual upright. Such individuals, when they become depressed, do
so gradually, and characterize their depression not in mood or affective
terms, but in body symptoms (often termed hypochondriacal) and are
,

:

'

,

�Page 2

Berton Rousche

September 2h, 197h

generally poor therapeutic risks. The outcome you describe with convulsive therapy is rate, since patients who have her background are
infrequently treated with this therapy. One of the limitations in
getting therapists to have adequate experience with convulsive therapy
is the prevailing social attitude that the therapy has less success
than the psychotherapies, that it is less elegant, and that it repre—
sents (in some minds) a failure of a 'better' therapy. Indeed, one
would guess that the consulting psychiatrist was reluctant to recommend
Regr tfully, had he chosen a form of
this candidate for this therapy.convulsign
there " in which the appli—
the therapy called "unilateral
cation of the electrodes is not to both temple, but to the scalp overlying the non—dominant cerebral hemisphere, the complaints would
surely have been less, for this therapy yields allmet equivalent therapeutic change with decreased effects on memory and recall.
There are also many errors of fact. The historical origins
of convulsive therapy are not usually related to the experiences of
Reil, but rather to the interest aroused in the biological causes of
insanity by the successful treatment of general paresis by fever
therapy by Wagner von Jsuregg. This observation was universally
hailed as a step forward in the treatment of the insane (yon Jsuregg
receiyed the Nobel Prize for medicine for this obserVatioh) and led
many scientists in Europe to-seek other biological rays to relieve the
symptOms of the mentally ill.- Convulsive therapy is usually described
as originating in the lehdrstories of the Hungarian, Ladislas von Meduna,
who Observed that schizophrenia was rare among epileptics and that
;-epilepsy was rune among those with schizophrenia. Seeking_a way to
'rnlieve the plight of severe psynhotics, he tried to simulate epilepsy
hy'intrayenous administrations tirst of camphor, then of pentelenetetrasol
"(Metrszole). The first-patients improved markedly and it was following
his early reports that the Italians, Cerletti and Bini, tried electrical
itinductions of seizures.

»1

,

;

,

Electro—eonvulsive therapy has gone through many'modifications
‘hin the past 38 years. The techniques of administration have improved
(succinylcholine is the latest of the muscle relaxants; the use of a
gﬂ-sedstive, usually Brevital, is not to improve breathing, but to pro-

vide relaxation for the patient before treatment and to-reduce the
excitement which occasionally is seen after a seizure, unilateral
seisures and flurothyl seizures are used in selected cases, etc.).
‘iOur understanding has gone from ideas that the treatment is a punish—
nent for sins, or to frighten the patient to health, through the stage
where the therapy was related to amnesia, to present views uhich ascribe

“K\\\
\

�Berton Roueche

September 2“. l97h

Page 3

to the biochemical hhenges which result from the seizures.
Indeed, the therapy is seen to produce long—lasting biochemical changes
in the central nervous system which are remedial to depressive mood
and psychotic idention, in appropriately selected patients.
improvement

carp about a few specific errors. Insulin come therapy is
not in widespread use. For example, there is no insulin coma therapy
unit in a community hospital in New York. It is far from the inspiretionsl prototype of electroconvulsive therapy since Sahel clearly separ~'
sted insulin come from the convulsive therapies, as did many of his
followers.
To

ECT

cemphor were used

I

first

was not the

earlier.

convulsive therapy - metrezole and

surprised by the quotations from Noyes end Kalb, Hope and
Adams, and Aubrey Lewis for none of these authors have written on the
subject within the past two decades. The quotations from Squires end
Ottosson are appropriate. Ottosson is one of the most experienced
observers of convulsive therapy and it may have served him better to
quote from his more recent studies, and those of his co—VDrkers,
Lsurell and d'Elis, then to use an older study. Squires is a young
am

who hes done only one experiment.
The gho—
"New
Home
from
Medical
Encyclopedia" is probably accurate.’
the
tstion
but one would wonder why you have selected this lsy volume as an

experimental psychologist

authority to quote in the

New

Yorker.

In sun, I em disappointed that the New Yorker, known and read
for its accuracy and fine reporting, sew fit to publish a single case
report, with many errors of feet in discussion therebydoing e dis~
service to the many patients uho‘will undoubtedly read or be given
this article, Ind who will be scored out of their wits if a physician
recommends this therapy. The harm that has been done will never be
known by you, but the many therapists who will find it more difficult
to use this therapy when it is useful will have reason to remember
you, as will the families that will have lost a member by suicide..
—

A

Should you wish to reach other scientists who may find your
report a disservice, I suggest you call Dr. martin Kata, head or the
Clinical Research Branch of the National Institute of Nentel Health,
or such concultants to the NIMH as Dr. Seymour Katy, Harvard Medical

School, Dr. Lather Knlinovsky of the New York Medical College, or
Dr. Charles Shegsss, of Temple University (also this year' s President
of the Society of Biological Psychiatry and the American Psychopatho-

logicsl Association).

‘

�Berton Roueche

Page h

You may

Septuﬂber 2h, 197h

also vish to read some of the more recent volumes
to assist you, I am appending citationa that are

on the subject. and
well known.

Lastly. I would suggest that you spend a week studying a ward
of chronic mentally 111 (in any State mental hospital) and a week visiting laboratorics renoarching the nawnr tharnpiea of tho_mantally ill.
Perhaps than you may be able to write a more balancoaroaponse to your~

self.

‘

Sincercly yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

cc:

Peter F. Fleischmann, President

The New Yorker Magazine,

Inc.

Kalinowsky, L. and Hippius, H. Pharmacological, Cbnvulsive and ether
Sbmatia freatmunts

in Phyahiatry,

N.

Y., Grune and Stratten,
'

1969.

Fink, M., Katy,

8.,

EcGaugh,

Cbnvulaivc Therapy,

Fink.

M.

J.

and Williams

T., Pbyahobiology qf

Whahington; V. H. Winston and Son, 19TH.

Convulsive Therapy, Saminara

in Phyahiatry, 1g; 1972.

/

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                    <text>July 15, 1968
Mr. Jerome serchuck

Ends Laboratories
1000 Stewart
Garden City, New York 11533
Dear Mr. Serchuck:

our luncheon on Friday, and I want to thank you
was
for the candor and the fine cooperation sf Ends Laboratories which
assessment
expressed. we look forward to the opportunity to continue the
of naloxone, and hope that such studies will improve the present care
provided these mentally ill.

I very

much enjoyed

presentation and the attitudes expressed suggest, regrettably,
has
that an adversary relationship, rather than one of cooperation,
denands
that
developed. For my part, I must apologise for my demands,—
in
program
study
experimental
maintain
an
desire
to
are expressed in a
and
Federal
by
and
State
support
continual
which
justification
man
requires
to a maintenance
authorities. We see the ready acquiescence of the community
drug treatment model (as the enclosed report indicates), and regret that
The

this is occurring without sufficient independent extensive testing.

that some of the problems in the evaluation
active consultations between industry and
the clinicians. My suggestion is for an active collaborative relationship,
so that the course of this complex program may be optimised. Such arrangements
between industry and the academic community are not novel and may be useful

The essence of my argument is
of naloxone may be averted by more

here.

thanks for a most pleasant luncheon and for the assurance of
continued supplies of naloxone.
Again

my

Sincerely yours,
max

Fink,

M.D.

Director, Division of
Psychopharmscology

Mrzkp

cc: Alfred M. Freedman,
Max Beltand, M.D.

M.D.

one. (2)

P.S. I am enclosing a recent review of the EEG studies of psychoactive
Dr. Dunn and consider such
drugs. Perhaps you may share thishewithalready
doing these in St. Louis
is
Perhap.
gtudigg formplindOne.
or Princeton.

�</text>
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                    <text>-

.1

'1,

--..n—~A,~....«

mr-Ww-Vwam—rn

ransom

”2:15"

"rw

July 21,

'w'r

.1“:

1970

Mr. Jerome Serchuck, Vice Pres.
Bndo Laboratories, Inc.
1000 Stewart Avenue
Garden City, New York 11530

DW-a'ﬁzuﬁm

mn'r'rrnpum

or“,

Dear Mr. Serchuck:

TJ‘J'SW

Both A1 Freedman and I thank you for your prompt reply and
favorable consideration of our request to continue supplies of
naloxone for clinical trial in the treatment of opiate dependence.
The proposed supply

of

6

kilograms of naloxone,

3

kilograms

by November 1, 1970 and 1 1/2 kilograms each by December 1, 1970
and January 1, 1971 is satisfactory and will permit us to undertake

our present

clinical assay.

We have discussed with Dr. Jacobson the formulation of naloxone
and he has assured us of his coeperation in providing the supplies in
either tablets or liquid vehicle, as most feasible for the study.

On behalf of the College and the New York State Narcotic
Addiction Control Commission we are indeed grateful that you are
considering supplying this at no direct cost to the people of the

State of
on

.

New

York.

My personal thanks for your cooperation
behalf of this program.

and sincere

Sincerely yours,
mawr{mm.xrw.w

Max

Fink, M.D.

Professor of Psychiatry

“1r-":w=-vmmmvzwm'“wf’w

'1'":

‘W

WWW)?”

we

m
‘

MF:kt

efforts

�</text>
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                    <text>April 23, 1969

Sesata
Sales Representative
The New York Hilton
1335 Avenue of the Americas

Mr. Joseph E.

New

York,

New

York 10019

Dear Mr. Sesata:

Following our discussions and your memorandum of March 28,
iike to reserve the Mercury Bailroom and Promenade for
meetings of the American Psychopathoiogical Association on
Friday. February 13, and Saturday, February 14, 1970. would
you piease arrange the necessary documents for our signature?
we

would

Sincerely yours,
Fink,
Secretary

Max

Mszp

M.D.

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                    <text>(W,

.0...

Dacanbar 3, 1968
Dr. Savaringhauaa

Editor

Currant Therapaucic Raaaarch
520

Haw

Fifth

York,

Awanuc
Haw

York

Daar Dr. Savoringhaua:

are plaaaad to submit tha report, "Liquid Butaparaaina
in tha Traatlant of Chronic Paychoaia in a Mantal Haalth Clinic"
for your conaidaration for publication in Currant Therapautic
Ha

iaaaarch.

Thank ynu

for your conaidaration.
Sincerely youra,
ﬂax Fink, H.D.

Profaaaor of Paychiatry

I

Hszp

�</text>
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                    <text>m7..——-‘vrv—

4-1"lem-‘IIer':&lt;w.r-v—ernvfn~1.m—.ﬂﬁm

November 29, 1956

any;

Wm:

an

Chairman

of the Editorial Beam
Research Press, Inc.

'

Wutic
520 Fifth Avenue
New

'

York,

New

.
'

York

Dear Dr. Severinghaus:

for your, letterof Novexnben 22, .1986 micatingr
in Schizophrenia" will be
that “Clinical Trial of MothixeneCement
issue
TRpruc' Rea-wok.
the
January
of
published in
Citation No. 7 has been exhumed for publication to the
Thank you

‘

Iowa
be

06 New

listed

Dix/.196

but has not yet been accepted.

as "to be published. "

.

It

should

.

Citation No. ,8, is already in galley and $3th appear in
one of the femoommg issues of Canpaehwiue, Payduéax/Ly.
Since the latest issue of Cmnpmhwéve Paychmay was the
August issue, I would expect this to appear in Volume '7.
Thank yOu for- your consideration.
,

Sincerely yours ,
Fink, M.D.
Professor Of Psychiatry

Max

MFUcp

cc: Dr. 11211

Dr. Simeon

..

‘

�</text>
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                    <text>-'

mun

.w ~‘Y"V\‘!

warm-myur-n»:

w

:

x~151§~n~v&gt;m4w£aﬂ yo. aw.

«n» .-.v

.

x

_

,t,

,.,

,

..--.

3—»

—_‘V‘_-'~,11'.'u

-

r..._;-,.g.—

..-

..

._..

.

ym;

, Y7

.,

December 3, 1968
Dr. Savoringhauae , Editor

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New York

Dear Dr. Savoringhaua:
We are pleased to submit the report, "Liquid Butaporazinc
in the Treatment of Chronic Psychosis in a Hantal Health Clinic"
for your consideration for publication in Current Thorageutic

Research.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Key :3. 1964

Steel!
national Library of Medicine

Mr. V;

Whehlnsten, D. C.

neer'nr. Sunni}:
During the recent Eastern

Jule:

Computer Conference.

I had

visit the Rational Library of Medicine} During
the: tour. Mme C. J. Anetta indicated that the part of your

occasion te

programs related to the retrieval of citations from the 1963
Index undieu51wee new undergoing triel. I am writing to eug~
gust e eelleboretive etudy which may indicate the extent to
which your reviews eetuelly ere eucaeeeful far 1963.

I have recently eeupleted I review of the citations under the
headings ef “EEG and Renee Feyehopbermecelogy“ for the period
1952~1962. This iiet is new in press and will be pdbllehed
as Supplement 23 to the EEG Journal. For the past few nunthe
I heve had my useletence cull Ehe literature for citation:
for 1963. The descriptors to be used are psychotropic end

hallucinogenic drugs,

It veuld be

EEG

recordings, and

human

subjects.

nutuelly helpful. I believe. 1f‘90u‘weuld be

V111-

ieg to undertake a review of the literature using your necked},
and cementing it to the citations available to us at the
present tine. If each a collaborative study is of interest
to yea, I wenld be pleased to send you e detailed 11:: ef the
descriptor: that we need, ea well as to submit a 11!: of the

citation:

now

available far that period.

Sincerely yours,

H“

”at,

Director

mm

n.

D.

�</text>
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                    <text>—-~-——

~ v— —,.u~. V“...

.v» 'Iww-rvw-v'uv

WW.”wu-‘wtmwwmw‘m.wv~

.A

N».

...,-‘ 7.”... v-W4W¢\Ir~"mv—. mm...”
.

June

u“...— .. "u.“ ._ 7—H”,

mm..-

u‘lvlww‘ww—‘erv. mmmmw

-'.YMww'-—m

1 , 196%

Misc Winifred Sewall
Deputy Chief, Bibliographic

Services Division
National Library of Madicine
Bethesda 14. Maryland

Dear hiss Sewell:

I

am

most pleased

that

um

will be dble to coupatato with the

National Library of Medicina and concomitantly determine the
accuracy of our hand search for information. The terms from
the Madical Subject Headings of the Index Mbdicus which "B
have requested are attached, and fall into three lists. From
our point of view. the articles which shauld be included are
those which relate to elactroencephalography, in human sub~
jecta.and with the concurrent use or the effects of drugs
having or presumed to hava psychotrcpic action. For this
reason, I would suggast that the search be for articles which
satisfy three criteria coneuxtently, 1,g., EEG and subjects
and drugs.

receipt of your list wa will chock
be glad to discuss any discrepancies.

Upon

'

it

against our: and

Sincerely yours,
Ma: Fink, H. D.

Diractor

242/51»

Att.

rm,

�</text>
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                    <text>July 20, 1964
uiae Winifred Sewalli
Deputy Chief
Bibliographie Servieee'niviaion
National Library of Medicine
Bethesda, Maryland 20203
Dear Mien Sewell:
we

have reviewed the

request. your

citations sent to us in response to our

number 3119370.

.

or the 63 citatione which fit our eriteria, there were 28 that
were relevant to our interests and were not in our lists. 14_
rataraeeea were matches between the two lists. 21 references
appeared in the E.L.M. list which appeared to us to be related
primarily to epileptic disorders. or to animal studies. or to
atediee in neurological subjects. aha were therefore not of

interest to ea.

The

principal reason: for these overhinclueiona

were the more apeeifie nature of our studies. exeluding as
do neurological groupe end patients.

.

we

In addition, when we checked our citations. we found 14 which
this search did not retrieve. “A copy of that list is enclosed.
Alan, there were articles in two books which were highly rele~
want. and 8 abstracts which we believe are important to obtain
early in a search. as this gives we an idea as to who may be
producing data in the near feture. copies of these-citations
are alao eacloeed..
The principal reason for the talee~hite would be the restricted
nature of our needs, and it was no problem to cull theee'from
your citations. However. the reason for the misses is lees
obvious. In part, it may reflect the feet that electroencephalocrane were a smaller part of this study and were only retrieved
by us because of our epetial interest.

In general. we search was excellaet and I believe that as your
liata become more inclusive, we would be most pleased to be able

to participate.

Thank you very math

for your eooperation.
Sincerely yours;

HI/jb
ﬁne.

Max
'

I

Fink,

Director

M.D.

�</text>
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                    <text>p.

my

May

28, l97h

Gordon Barclay, Ph.D.
Director of Research

.

Department of Mental Hygiene
Albany, New York

,

Dear Dr. Barclay:
At a recent meeting of the
Jonathan 0. Cole brought the problems

investigators, Dr.
that are increasingly
facing researchers in various States of the nation to our attention.
He indicated that each Itate was frequently changing the laws and
suggested we contact the agencies in our itate to Obtain the latest
information regarding the laws now extant.
ECDEU

I have been carrying our research in human subjects in
various institutions of the State for many years, lately, at the
V. A. Hospital in Horthport, on the campus at Stony Brook, and soon
at the Central Islip State Hospital. I would appreciate references
to the laws applicable to studies in human subjects, including
patients who are mentally ill and normal volunteers. we study such
special problems as the eValuation of new treatments (including
drugs and convulsive therapy), and use controlled substances (can»
nabis and opiates)..

.—

-,.
.y

ma...“

»(

33w,“

Is there a codification of the laws applicable to these
research problems? Is it possible to obtain copies through your
office, or can you refer me to another that may make the documents
available?

.
,,._,

Many

thanks.

,.,m.......,.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

°

�</text>
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                    <text>pvnwwvawwrwv.

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May

10, 197h

Mrs. Mildred K. Lehman

Chief, Mental Health
Rational Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
_

Dear Mrs. Lehman:

I very mtch enjoyed the conference

on April 17, 197h, and

I am indeed grateful fbr the tape. I have already received a number
of calls and letters tram "patients" who read an overuenthusiastic
summary which appeared in a Chicago newspaper.

I hope the meeting served a useful purpose fbr
glad to have had the opportunity to participate.

NIMH

and was

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
M3:
MF:ed

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                    <text>-.
”n.5,

"mtw—WWWWW'HV“;W

May

Richard Shader,

23, 1977

M.D.

132 Homer Street
Newton Center, Massachusetts

02159

Dear Dick,

I have been using the sedation threshold as a diagnostic
1955, and have not had any complications associated with
this procedure. Recently, I have re—instituted a study program for
another assessment of this test, using the RDC as diagnostic

test since

criteria; in the belief that much of the difficulty with the original
test data was inherent in the lability of diagnosis, and not in the
specificity of the test. To do the present study, my associates

Drs. Martin Heymand Had Timothy Ts'o have prepared and filed a
protocol which has been approved by the appropriate review committees
of the VA Hospital, Northport, and the Long Island Research Institute.
In both protocols, permission has been given to carry out tests in
patients prior to definitive treatment with drugs or EST, and to
repeat the test periodically during the treatment course to assess
the changes in the test with cahnged behavior. Dosages of amobarbital
up to 1.0 gram are given at the rate of 0.5 mg/kg/HO seconds following
the descriptions of Shagass, up to nystagmus, slurred speech and
defined EEG cahnges (higher voltage 20-25 Hz spindling).
In filing for these studies we referred to the extensive
data reported by Shagass (for reference see my summary in Katz, Cole
and Barton: The Role of’Msthodblogy in Classification in Psychiatry
and Psychopathology, PHS publication 1584, 1968; to the volume by
Gordon ClaridgezPersonality and Arousal, Oxford and London, Pergamon
Press, 1967, 274 pp.; and the reports by Mario Perez-Reyes in
Williams, Katz and Shield: Recent Adbanaes in the Psychobiology of
the Depressive Illnesses, DHEW publication 70-9053, 1972. It was
our impression that these reports supported our estimates regarding
the safety of the procedure.

I trust these date are helpful.

Good luck

in your studies.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>1—1

WVWFVW

'iu—r'.

“ﬁrm—w

v
v

AFWW,-w

V

April 24, 1986

Richard I. Shader, MD.
Department of Psychiatry
Tufts University School of Mediocine
171

Harrison Avenue

Box l007
Boston, MA 02111

Dear Dick,
A few weks ago, l was consulted on the question of hepatotoxicity to
phenelzine. After a literature survey, in which 1 found no examples to justify an

association, 1 re-read the PDR package insert, to find that there are assertions of
risk. in some texts, risks are described for the class of compounds, usually including
iproniazid as well as phenelzine and tranylcypromine. i did find many reports of
toxicity to iproniazid, and I wonder if the package insert description is not a
spillover, 'guiit by association', from the chemical similarity of the two

compounds?
I

would like to pose a question to your experts for the Journal:

What is the degree of risk of hepatotoxicity for depressed patients
receiving phenelzine therapy? Is the risk sufficient to require that we modify the
written advice (as to diet and risks) we regularly give our patients before we

institute this therapy?

Thanks for your help. My best regards.
Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

�</text>
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