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                    <text>0‘.

December 20, 1966

Dr. Alain Sanseigne

The Squibb Institute
Georges Road
New

Brunswick,

New

for Medical Research

Jersey

Dear Alain,
Enclosed is a protocol of our proposed fluphemine
decanoate study in ammlatory psydntic patients at the
New Ymk Medical College - Metropolitan Hospital Medical
Center. A coupleted set of PM forms «md my mimlum
vitae am also enclosed for your files. This protocol
follows our recent discussions closely. Patients receiving

otrmrphencthiszineemfirsttobeu‘ansfmedtooral

fluphenazine and then to intrumscular decenoste. Patients
not receiving phenothiszinee are first to receive oral
fluphenazine and then the intmuusculsr preparation.

Asaomtmlgmuplsterintmstudy, anmnbercf
patients who are doing well on the intamsoular prepmtion
are to continue receiving injections but with the fluphenezine
at 1/100 the dose. By this novel method, I believe we can
obtain some mderstarm of the direct phannaoologicel effects
of ﬂuplwmzine.

Ifthisetudymeetswithymmappmval,wewillhesble

to undertake the first transfers or minismtions of oral
flupl’aemzine about mid—Jetway and the intrumswlar minions-timsearlyinf‘ebmary. Wewillrequirecontinuedmppliespf
omlfluptmzine, fluphmazinedecemate,andabmtApril, a
lwstruxgthfluphenezinedecanoate.

Initially, 200 cc of flnphemzim decmoate at a
25 nag/cc would be useful This could be
wppliedinsmallmlti—pwpcsevioleor2ccanpules,
whichever is available. As for the ﬂupimxazine hydrochloride,
concentration of

Imtetruttmususlprepmtimisasl, 2.5m5ngtablets.
Shmmmplmmingdoesgessveragixghomwmg,canlem
tablets be supplied? If so, an initial supply of 2000 tablets

would be helpful. In addition, a placebo form (1000 tablets)
would provide us with madam:
ﬂexibility in the moment

of our patients.

�H"

g 5,§

Deoanber 20, 1966

'I’hedatatobeprovidedwillincludeslmtcasemies
the fem
will

mquast
clinical laboratory Narration. I
not available
these
are
If
usedbthNIMH-BCDHmegzwm.
and the

wrenthesunyiabegun,mwillcreateourcwnfommdsem1t
towaoryourcmments.
In addition to the supplies of mdicatinn, which
large study will be a‘ significant cmtribution to the
I would request your consideration of a grant—~in-aide
to be made available at the end of the study for data
appropriate case reports and a final evaluation.

I look
My

forward

of $8,000
analysis,

to your cements and to undertaldng this study.

best regards.
Sincerely yours ,
Pink, 3.1).
Professor of Psychiaty

Max

81108 0

for such a

pmgmn,

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                    <text>March 16 , 1967

Dr. Alain Sanseigne
The Squibb Institute for Medical Research
Georges Road
New Brunswick, New Jersey
.

Dear Alain,

is a draft

copy of the summary information in the
deoanoate project. This contains only the
most important clinical informatim , for we are planning to submit
Enclosed

first fluphenazine

this to a general medical journal.

have also written a longer version, which contains the
data, and a cepy of this
report will be submitted with all the definitive data of the
project. Most of the infomatim is now in my hands except for
four additional summaries of clinical data which Dr. Keskiner
has prunised to send me shortly. As soon as this information
is received, I will submit a full documentation of this initial
study program.
We

more conventional psychophazmcological

‘

draft copy is still undergoing review and I
for your cements. As soon as a definitive
draft is available, this will be sent to you for your distribution.

The enclosed
would be grateful

It was

kind of Dr. Joy to send me the letter from England,
available to him copies of the definitive draft
for your English colleagues.
and

I will
Dr.

make

Simonhastakenanactivepartinthe smdypmgmm

in New York and we are ready to develop the fluphenazine decanoate
study in the Mental Hygiene Clinic. Can you tell me when supplies
will be available?

Hybestregazdstoywandymrclmdngwife.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>February 27 , 1957
Dr. Alain Sanseigne
The Squibb Institute
Georges Road
New

Brunswick,

New

for Medical Research

Jersey

Dear Alain,
me to participate in the
It was kind of you to invite
must
discussion of fluphenazine. I
tell you that I enjoyed

the afternoon very much, and I hope that the contribution
was helpful to you and your associates. I am impressed with
the data of fluphenazine decanoate, and am anxious that this
program continue. Surely, a liberalization of the dosage
ranges will make fluphenazine me acceptable to hospital
psyclﬁaatrists.
'

I also have had an opportunity to read the surmary of
data on 8010,1496. This is indeed an interesting canpound
and Dr. Horovitz is to be congratulated on the description
he provided. If there is an opportunity to study this
compound later this spring, I believe we would be interested
in doing so.

I tell you how much I enjoyed our dinner Friday
evening? Your wife and yourself were outstanding hosts and
provided an evening that Turan and I will long remember.
Need

My

best personal regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

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April

26 , 1967

Dr. Alain Senseigne
Associate Clinical Research Director
22.

R. Squibb and $018

Georges Road
New Brunswick,

New

Jersey

08903

Dear Alain,
Jovan and

I

have revised the fluphenazine protocol

permit the possible inclusion of the enanthate. If this
revision meets your approval, would you please call me?

already have a number ’of patients in the clinic
and are able to begin the decanoate part of the study as
soon as you send us'the supplies.
We

Sincerely yours ,
mm.
mm,
Professor of Psychiatry
MF:kp

to

�</text>
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                    <text>April 25,

1967

Dr. Alain Sanseigne

Associate Clinical Research Director
E. R. Squibb and Sons

Georges Road
New Bnmswick,

New

Jersey

08903

Dear Alain;
Enclosed

is the final

decanoate study.
My

swunary of our first fluphenazine
any questions, please call me.

If them are

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

HFﬂcp

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                    <text>April

25 , 1967

Dr. Alain Sanseigne
Associate Clinical Research Director
E. R. Squibb and Sons
Georges Road
New

Brmswick,

New

Jersey

08903

Dear Alain,
Enclosed is the proposed protocol for high dose and very
high dose fluphenazine therapy, as you requested in our last
meeting with Dr. Itil.

In addition to the protocol, we are enclosing ooPies of
the psychopathological rating scales , both in the English and
Turkish versions, and the laboratory data sheet. You will note
that these forms are organized for machine processing and the
equivalent of the Turkish and English forms should make possible

a detailed analysis of the changes in psychopathology.
Thank you very much

for your interest.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.
cc: Dr.

Itil

�</text>
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                <elementTextContainer>
                  <elementText elementTextId="105500">
                    <text>"I ..

A

,

'_

1,7,, "m“,

,.,

WW,” ,....

"wrwmlk u

,w,

1.“. "A."

.11,,mr.whwlwh -r

v

,_...., __.,v..,,.n._w

3,":

_,~,4-.

r

,7.“

w...” “4,7-.." an? ~._,._‘-p,.

«A.-

&lt;

w'-"'r"—“

My-”

....

m...“

,_
l

”w:

{mewgm

u
1"
«m.

May 21+,

1967

Dr. Alain Sanseigne
Associate Clinical Research Director
E. R. Squibb and Sons

Georges Rd.
New Bnmswick,

New

Jersey

08903

Dear Alain,

.

Enclosed are two copies of the revised protocol on the
fluphczmzine project. The only change is on page two where
Dr. Pclvan correctly edited pan: of the second
Would

nwfﬂ‘ﬂ'nuwrwrrnrvﬂ

to replace your
it be possible
Many

revised drafts?

thanks.

mph.

copies with these.

Sincerely yours ,
Max

Fink, Md).

mecssor of Paydxiatzy

MF:kp

.7...» ..,. r:~('-'r‘r.qlm'n1)“

13,—‘t-I'w.

r

~

..

war

.«1;

-

,

m)

(—

v«--

�</text>
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                    <text>�Dr. Sanseigne

‘

a2-

These cmzplaints are picayune

I can only agree with the data
.

Turan called

Istanbul.

me

.

.

&gt;

August 15, 1967‘

but, except tbese omnts,»

and oonclusibns.

and medial discuss bigh‘ dose study

is

in

so important as to provide any difficulty
for any of our friends and I do hope that our encowagerrent of
this program has not anbmessed you: in any Way. We will
probably. help the Tlmkish paychiat-rists mdervtake such a study,
if we can obtain the supplies for than.

-

No

study

,

In the ,nwanwhile, our study in New York is going well and
row, to our dmgr‘in, tint Many of the arbulatory patients
who were apparently doing well on ﬁnalmged phenothiazine mdioatim,
have been doing just as well On plaeebo! We have many ﬁbre patients
in our stMy group thanhave reoeived flupbenazine decanoate. But I
.

we

have

am

sure the {timbers will: morease..

'

Many

‘

My

thanks for, the opportlmity to see the
'Sineerfely yours ,
‘

‘7

MFEkp

..

o'T'Tv‘P'i‘J"

.-y

w-.

..Wur\

demate swarms.

best personal regards.

,'

Fink; M.D.
,
Professor of Psychiatry

Max

�</text>
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                    <text>..

v-mw-

.v-n

.1..-

Wuwnr'J—vvr

September 7, 1967

~

Dr. Alain Sanseigne

Associate Clinical Research Director
E. R. Squibb and Sons
Georges Road
New

Brunswick,

New

Jersey 08903

Dear Alain,

Enclosed is the revised fluphenazine decanoate/enanthate
Thank you for your help.

project.

'

In our discussions I believe we indicated that we could
after
start a few patients on oral fluphenazine immediately
the placebo period as a priming treatment. Or. Bucci seems
to recall this and was asking me for some fluphenazine. If
this isﬁagreeable, I will modify the project so that in
selected cases he will be allowed to use a priming dose.

tablets) of Prolixin
hydrochloride in the largest available amount (5 mg)? Thank
Would you send me a supply (lOOO

you very much.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                  <elementText elementTextId="105554">
                    <text>n
A»,

.«&lt;

«r

wrn—vm-mvwmmrm

v,

~11”

3.5."

my...

4—...wr.“... n,
q

"1~

v.

;nv—v-y'ﬂi"‘I'W‘W'J-MW*SWWWW'EtrLJv-,mp-Jrvgx v

InwptiT-s

Frv.‘ ..m.¢.mn—~~.¢w-m-

,an

,~rv.~wﬂwm&lt;wymwnm Y‘lan’vn‘JMHP‘r-umw»

J...” "my...

November 22, 1957

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York, New York

near Alain,
Dr. Denham

enjoyed the

visited with

visit

practitioner.

He

us

this

morning and I hope he

as much as I did. He is a charming experimental
sat in on a meeting with the patients and

their questions in a witty and enthusiastic
ﬁrs. Eucci ané Simeon joined me to discuss his
experiences with fiuphenazine and we found his reports interesting

answered some of

manner.
and

heipfui.

Thank you

regards.

for suggesting that

he

visit

with us.
r

Sincereiy yours,
Fink, %.9.
Professor of Psychiatry.

Max

MFtkp

My

best

Vina-"ulna suym- .j‘v‘g "mum

�</text>
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v

ww'—~'rw~w-wnv

.

,

.

ww-

'

,

December

l3.

1967

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New York, New York

Sear Alain,
I have been asked by the Separtment's Chariman to present
of our findings in our new drug studies to the full
department staff on Friday, February 2. I have decided to present
the Prolixin decanoate and enanthate material. I would be pleased
some

if

you would be a

discussant.

I am also preparing some lectures for the residents and as
this will take place on Friday from ll to 12, I should like to
ask you to participate with me that day at ll o'clock.
The
‘

i

My

staff conference is
best wishes for

from 12:15pm

a Happy

New

to 2:00

pm.

Year.

Sincerely yours,

E

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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.

.m

..

ﬂ.
.,

..._,-..

alas-r

February 6. 1968
Dr. Alain Sanseigne

Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

It

was very kind of you to participate in our program on
I enjoyed very much your hospitality.
and
Friday

mentioned in our discussion, I recently came across
the following citation which will interest you.
As I

Czerwenka-wenkstetten, H. and Hoffmann. @Clinical Experiences with Helleril-retard.
Mien. Klin. Wschr., 1966, 78-48: 845-847.
Again my thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

P.S.

Enclosed

is

a

the ticket with you.

ticket for “Titicut Follies.“ Please bring

�</text>
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",4

m—Apﬂ',’(‘ﬁv~hrjmwrr&lt;

January 29. 1968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York.

New

York

Deer Alain,

Enclosed is a copy of the staff announcements for
this Friday's presentation. and a copy of Luigi’s notes.
Dr. Simeon will report on the data from Missouri, and a
copy of that report is enclosed.
As I mentioned, I would be grateful if you would join
me about quarter of eleven, l5th floor, Metropolitan Hospital
in the Mental Health Clinic (inquire at the psychiatric office).
At ll o'clock I would like you to Join me in talking to the
resident physicians about the methods ind problems in new drug
evaluation. They have had two lectures already, one on the
history of psychooharmacology and one on models and classifications
0 drugs.

Turan

is planning to Join the

can have lunch afterwards.
My

noon

lecture

and perhaps we

best regards.
Sincerely yours.

4.,

Fink, M.D.
Professor of Psychiatry

Max

_.

we!

we

Wm

.mm

MF:kp

�</text>
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                    <text>January

ll,

l968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue

New

York.

New

York

Dear Alain,
I look forward to having you join us on February 2.
Enclosed is a list of the seminars in psychopharmecology
for the residents and I look forward to having you discuss
with them the practices and problems of new drug evaluations.
The presentation will take place at ll 00 am at
Metropolitan Hospital (97th Street and First Avenue) in
the fifteenth floor classroom. The group will consist
primarily of first year residents and some additional
members of the staff.

.

AV:

V

w-wvauw;7-l\-

"

'~‘r

At l2:l5 pm we plan to meet with the whole staff to
present our experiences with long acting fluphenazine.
Dr. Bucci is away, but as soon as he returns he will summarize
our data and we hope we can get it to you before the presenta~

tion.

www-

'
xv:

_my:~mtrnvmr

Incidentally. I received the corrected text from the
Anchivea 05 Genenaz Payehiatay of our report and this should
appear shortly. I have called Mr. Bold and asked him how many
reprints he would like.
I look forward

-

to your participation in our program.

best personal regards.

Sincerely yours,
Fink. h.D.
Professor of Psychiatry

Max

MF:kp

My

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                    <text>May

10, 1968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

draft

is a
I have

copy of the summary of the Sitges
Symposium.
prepared this as a summary for my staff,
but
may be useful if you plan to prepare a volume of the

Enclosed

it

Proceedings.

that

you do prepare a volume, we would
like to summarize our observations in New York more adequately
than are represented in this summary.

In the event

As I

indicated

Dr. David Graubert

on

the phone. one of

my

is anxious to undertake

a

former associates,

clinical trial

of depot fluphenazine and if such a study could be structured,
we would be pleased to process the data in our center or assist
in any other way.
Thank you once again
the symposium very much.

for your kind remarks.
My best regards.

I

enjoyed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>.

:2‘

.Yw

-

mg

”-1

,_

we.

was“... “aw—g.

mam...r..r-qp.~u

v,‘&lt;’vw

vvu'v‘u» ..,;w-‘.-:~ ~.....nw.m.

-

.1,

“-7".

V

,

-,

-,-.v~»-..v,n..

., .,

“WV/wt MW. .w“,,___,. ”W,

,

.

.e.

July 18. l968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New York. New York
Dear Alain,
I enjoyed lunch very much and I hope that
under such pleasant circumstances more often.

in

Enclosed is

"A

we

can meet

Selected Bibliography of Electroencephalography

Psychopharmacology" which was published in 1964.

Human

It

is the definitive supplement to the first bibliography wtitten

by Mary Brazier and covering the period l936-50.

of Phogeeaa in Baain Reacaaeh.
This
was organized by Phillip
symposium
”Anticholinergic Drugs.“
and myself and the major portion of the editing of documents was
undertaken in my office. This symposium was the second which I
organized on the same subject. The first is published as part of
volume Advances in Biologioaz Paychiateg edited by Joseph Hortis,
the
966.
I am

also enclosing

Volume 28

interested in the tremendous value of
depot phenothiazine therapy, not only in treating chronic mentally
ill but in relieving acutely disturbed patients in a community
mental health center. If I can made a contribution to this
subject by assisting in the publication of the available data.
As

you know, I am

I would be
My

pleased to do so.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp
one o

7”

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                    <text>September 26, 1968
Dr. Alain Sanaeigne

Squibb International
460 Park Avenue
New York, New York
Dear Alain,

Enclosed is a final copy of the report "Depot Pluphenarine
in the Treatment of Psychosis in a Community Mental Health Clinic."
we would be pleased to have you conaider this for publication with
the other reports from Sitgea. In the event that this publication
is not forthcoming or inordinately delayed, I would appreciate your
release of this draft for aubnieaion for publication elsewhere.
As I indicated to Dr. Morkel. we are discontinuing all
administration of fluphenarine decanoate and are transferring
patients to the ananthate form. he soon as the transfer is
complete the remaining supplies of decanoate will be destroyed.
As you know, fluphanarine enahthata is now available for clinical
use in our Center.

again, I want to thank you for the opportunity to have
and to provide both our Division and the
Department with a new and useful form of treatment.
Once

carried out this study
my

beat personal regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp
013C 0

P.S.

I think if you read this draft carefully you will find
that the difference in incidence in extrepyramidal
effects is probably as much related to dosage problems
as to the drug since we believe we used too high initial
dosages too frequently in the early (FD) phases of the study.

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                    <text>October 29. 1968
Dr. Alain Sanseigne
Squibb International

909 Third Avenue
New York. hen York l0022
Dear Alain.

N,

”m,

“Hymn,

Enclosed are the individual case summaries for each
of the patients in the fluphenezine decanoate - fluphenezine
enanthate crossover study. More complete case records are
available in our files and will be supplied if you wish.
These summaries indicate the essential nature of the changes
accompanying the treatment and provide the backround for

our report which

..

we

submitted

earlier.

\wq

I

”New

trust these are helpful.

,.

Sincerely yours.

4;
i.

um,

«

a~

4‘:r

Fink. M.D.
Professor of Psychiatry

Max

w

v
4v-

nut-"mm

.OL-J‘I".

bemoan

u

mun-L

-

:w/rvnwuynv

:
N«'e'm:

was:

"auger

her

[’7'

7.

Inwnwsquvmuw

MF:kp

�</text>
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                    <text>January 31, 1969
Dr. Alain Sanseigne
Squibb Intarnational
ﬂew York City
Dear Alaina,

It was kind of yau to sand as the translation of the
Lumbart/Midenct report, which I have read with interest, and with some'
disappointmant. The concepts are good, bit as you know already, thare
is

no data and while

I

impressed. I fear that

am

not be stimulated to look into

this ptoblam.

my

colleagues will

studies, however, shculd do much to revive interest in
the high dose problem, and I look forward to hearing of your results.
Your

that I write

will

be pleased to know that Charles Shagaaa has aakad
a short chapter on tha longwacting fluphenazines for a

You

clinical
justics 1t antics.

forthcoming review of advance» in psychopharmscology in

I hope-that I will

practice.

Yaur

lunch soon

3

My

asaiatant

do the subject tbs

sounded deliciouu over the telephone. Roé.about

best ragards.
Sincerhly yours,

Max

Fink,

M.D.

�</text>
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                    <text>March

l3, l969

Dr. Alaln Sanselgne
Squlbb International
909 Thlrd Avenue

New

York, New York l0022

Dear Alaln,

Enclosed ls another report whlch was requested and whlch
should appear In a book edlted by Charles Shagass.

ulsh you would get a publlshar and
Lulgl Buccl would feel fultllled.
l

My

edltor so that

best regards.
Slncerely yours,
Max

Flnk, M.D.

Professor of Psychlatry
Mkap
60C .

�</text>
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                    <text>November

5,

1969

Dr. Alain Sanseigne
E. R. Squibb and Sons
Georges Road
New

Brunswick,

New

Jersey 08903

Dear Alain,

grateful for your kind assistance last week.
The study is now under way and I will submit protocols to the
idea, that
investigators you suggested. It is an intriguing
and
that we
I
hope
of a child psychopharmacology study unit,
will learn something new in the process.
I have continued to recommend Prolixin Enanthate in
problem cases and now have two patients who have required
more than doc/week for maintenance. Perhaps these higher
dosages, tested in Europe, should be made more commonly
known to the psychiatrists in this country.
I

am

most

Again,

my

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>Catcher 25, 1963

Alain

J. Sameime,

M.

Parka. Davis 8 Conway

D.

Research Laboratories
2800 Plymxth Road

Ann

Arbor,

madam

DaarDanmim:

Wm
dewinbaplcaaedtometwiﬁzywonﬁwafmmomofﬂm
Reﬁning toyowletterofmtobor 22.

In".

7.

Myoufm‘thematwialmyammm (II-#19“
21-515 which

I

found of genuine

intamst.
Sinoemly yours ,

fink, H. D.
m
Director

�</text>
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                    <text>Jammy 8.

J. meiw,
mu
Parke, Davis 5

M.

196‘;

D.

Inseam Labomtcries
2800 Plymouth Road

Ann Arbor,

madam

Daar Dr. Sanseigme:

Sommeks amywwemkindonmmtosubmitapm—
toool to us regarding Succinic Acid as an mama;- to the
Psyehanimetic Effect of Semyl, ymr Pmtoeol 395-4».
In reviewing this protocol, a

mater of quastims
believe
the diamostic clas—
emerged.
I
sification shmld be scrdzophmia and amicpaths.
On

page 3. sectim

Page a

H,

stimlated a problem in interpretation. It
mmloﬁoal and
the
airing
mistmtim of new «mamas.

thim

is
urinary
ﬂapmtooolimlies ﬁntﬂnlabomtorymatmpagekwouldbo
not mummy for us to carry out repeated

mm

repeated during drug administratim. mder am garment
organizatim, with mly me Laboratory tedmician maimed, we are
tumble to carry out those detamdnaticms, and these moans} either

bedshtaloraamotherpxovisimmdcifﬁmymmmssary.
In similar fashim, the Formal}: - Laboratory is me
In addition, the Rating Scale
that
are not able to
section related to EEG is incanplcte. mat mtim should be
deleted and any ratings that are provided will be in the ram of
quantitative statmts of frequency pattern change and will be
carried out by Dr. Itil. Because of prior comim‘ts of the
EEG laboratory, I believe it may not be possible to have the
we

mum.

�Swim,

Alain J.
January 8. 196“
Page

M.

No

electroenoopmlomm
done

D.

dunes panofthetrial, butﬂmywillbe

sufficiently fmquant to provide us with

infmtim.

If you mum be so kind ax to modify the laboratory
sections of this protocol, we shall be glad to sign it.
Sinaamly youm .
Pink.
m
Dimctw
Mf’mlg

ﬁne. 1

-

Pmtoool 395.4

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D.

�</text>
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                    <text>24mm 9, 1965

Smut”.
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                    <text>June

1'4 , 1965

Dr. Alain J. Smoaigta
Parke, Davis 5 Canpany

Departmzt of Clinical Investigation
Research Labomtorias
2800 Plymmth Road

km Arbor, Michigan

smeigna:
I am plowed to submit the

Door Dr.

oopy of a latter moantly
0.
Kelsey
indicating that our
remind
Moss
(Ci-395)
of
clinical
for
investigation has
spmomhip Samyl
been accepted by the Food and Drug Administratim. as IND 26110.
In accordmoa with Dr. Kelsoy's mmst, we have submitted the
micalm vitae of each of the investigators responsible to

from Dr.

me

as sponsor.

it

With this information, would
be possible for you to
mice supplies of Semyl for clinical investigation in our TR?
patients available to us? What infomtim would you like to

supplemt this request?
I want to thank you moo again for your halp in permitting
us to file our lattors with the FDA.
My

best regards.
Sincerely yours,
Max

Fink,

M. 1).

Professor of Psychiatry
I

HFﬂcp

enclosm

�</text>
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                    <text>.

Dr. Alain

J. Smigne
5

Parke, Davis

Cowmy

June 17, 1965

'

Department of Clinical Investigation

Laboratories
Ream
2800 Plymouth Road

Ann Arbor, Michigan

Dear Dr. Saweigxe:
Thank you very and: for yet»: call regarding Semyl. You
some work was being done in EEG analysis by
Dr. Komin. Perhaps you would be interested in this report
which I have just sent to 816‘ which will tell you something

indicated that

abOut the present Istatxm of our

art.

Sincerely yours,

Fm,
m
Professor of Psydﬁatry
McDo-

Mszp
enclosure

�</text>
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5:."

-“~Ls\—.~wnuvm‘

hwy:

June

2%, 1965

J. Sameigm
Depaxmnt of Clinical Investigation
Parke, Davis and Ccnpmy

Dr. Alain

2800 Plymouth Road
Ann Arbor, maxim

Boar Dr. Smeigne:

ﬂunk

«mules.

web for your supply of 20%
per cc of Semyl, which we received

you very

10 mg

in satisfactory condition

on June 22.

Sincerely yoﬁrs,
Max
4

HF2kp

Pink, M.D.

Professor of Psychiatry

�</text>
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Dr. Alain

J. Smaim

Parke, Davis 8 Oman);
1:

of Clinical Investigation

2800 Plymouth Road

km

W. Himigan

mar Dr. Sansoigm:

are unable to supply the FDA with the information
that they are requesting. If such is available without too
we): dismfm, my associates and I would like to be able
to supply this infomatim. If it is not too inconvmiwt
am am of than inquiries be
We

Mybastwishea

M?
forﬂnﬂw'fm.

Sincerely

yam ,

PM,
m
Professor of Psychiatry
MOD.

.

�</text>
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                    <text>April
Dr. Alain

J.

17 , 1967

Sanseigne

Associate Clinical Research Directw

E. R. Squibb and Sons
Georges Road
New

Brunswick,

New

Jersey

08903

Dear Alain,
have nede all the preparations for the fluphenazine
deoanoate study in the Mental Hygiene Clinic at Metropolitan
Hospital, and would be pleased to start as soon as you can
We

make supplies

available.

of a canparasion of the decanoate and the
enenthate forms is quite reasonable, and if the initial
experiences with the decanoate appear to go as well as I
anticipate, I do not think we would have any difficulty in
The suggestion

undertakingacoamarisonofthetmcompomds. Iwouldbe
delighted to discuss this with you.
Tl'xedraftcopyofthemportonProlixinDecaxmte is

mxdergoinganothermvisionandlplantobeinSt. Louis
this Ieekend. The reports of this first study are complete
and I have held than pending the completion of this report.
However, I will send themout topu before the report is
completed.

Sincerely yours ,
Fink, M.D.
Professor of Psychiauy

Max

Mchp

�</text>
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                    <text>wry—acr—
q
w.».=.~wmmv../mnw.,-- x I-K'»'
.

m

g:

'4

.. —,... mun-w.-s
1—9“7" .s'up». an“

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.
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w
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.

mummy-w mun-w, ‘w-wwr‘ ..‘ ‘~7’.«'-:~C_p-:qv~-ar«‘.(-3A"1IV'RMIVZ

"-ww:-r—;~v\'v-Y"ﬁYYn-“ww'ix‘

‘4,"

v

(m.

l,

October 10, 1967

.

-

V

.

~7‘
3r. R. Kaelbling
Associate Professor of Psychiatry
The Ohio State University
Department_of Psychiatry
.

7....

W.

V

430 west

“maven-v

.V

loth

Avenue
Columbus, Ohio 43210_

_

.

‘

{

~

‘Dear Dr. Kaelbling:

“VHF...“

has been some months-since we discussed Unilateral ECT
and-during the interim my associates‘and I have reviewed the
literature and decided to undertake a systematic study. Recognizing
that the populations available fer convulsive therapy studies in a
municipal hoSpital are limited; we have been most fortunate in
establishing a geod relationship with the staff at Gracie Square
HoSpitala This hospital is-a erivate facility with a very active
in—patient and euteoetient treatment program. Dr. Lothar Kalinowsky
has agreed to help_us in selecting cases both from his own popula~

It

v

-

»

y-Wpy-v-l

'M'J-

Mums

tion and from those of others at this hospital.

«7

«

WWVV

rv.‘

course, we reviewed your work carefully and were impressed
with the data presented in your unilateral studies. Gur'present
protocol calls for a comparison of unilateral (non—dominant) seizures
with bilateral seizures given at a customary_rate of three times a

~4\

Of

r

.714‘

-~..-

r:
:u

week.

Hurry-«w:

The

criteria for

change

will

be memory

.

tasks, quantitative

measures and behavioral scaless- If indeed the unilateral
seizures show lesser degrees of memory impairment and equivalent
of
clinical results, then_we would nape to undertake a comparison
and
the MMECT as described.by slachly, both in the unilateral

a“

EEG

-»~r

bilateral

modes.

"

'

‘

-.

Will be extending.both your work and that
of Paul Blachly.’ For this reason, and with the collaboration
sof'Dr. Kalinowsky, I would like to ask your permission to list
you as a consultant to this project. We have asked Dr. Blachly
and-he had'agreed to assist us. As you can guess, such a study
will be difficult to carry out with proper controls and we would
he encouraged if you would be able to assist us from your experiences
This will also give.us an epportonity to get to know more of your

,In this study

'

'

‘

we

experiences.

’

‘

say I_have your permission to
"'
this project?
'

My

1

.

best regards.

list you as's

consultant to

.

.Sincerely yours,
Fink, M.D.
Prefessor of PSychiatry
“

Max
L

MFrkp&gt;

.

“q..-

,

nrJ-~9~vvvwv

~-'-'-P"|--'

�</text>
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                    <text>September 13, 1967
Dr. Aiain Sanseigne

Associate Ciinicai Research Director

E. R. Squibb and Sons
Georges Road
New

Brunswick,

New

Jersey 08903

Dear Alain,

Enclosed is the latest reVision of the depot fiuphonazine
study as changed by us on Saturday. Please see page three.
I enjoyed being with you.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MszP
GﬂC.'

�</text>
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                    <text>March 29, 1967

Dr. Alain J. Sanseigne
Associate Medical Director
The Squibb

New

Institute for Medical Research

Brunswick,

New

Jersey

08903!

DearAlain,

I very much enjoyed the opportunity, once again, to
discuss the fluphenazine projects. Following our discussion,
I have made up a protocol entitled "Treatment of Schizobimenia

with Fluphenazine: High Dose and Very High Dose Therapies. "

Ihave sentthistoDr. Itilforhiscannentsandassoonas
I have received these, will send them on to you.

The first fluphenazine decanoate data is ready to be
into
put
folders, except for four additional smuaries. As
soon as these are carpleted, all the material will be sent

toymandshwldbeinywrhandswithintwomeks.
Sincerely yours ,

Pink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>November 1%, 1983

M We

Philip Sapir, Chief
8 Fallwahips Brands
National Instimta of Jamal Health
Dapartmnt of Pkalﬂx. Edumtim
Mr.

and Welfare

Ramada

24mm

1H.

Re:

I

07%32—431

I‘d-273.5%”
Famrly
‘

Dear Mr. Sapim

'

writing to request
this grant.

am

tuma' undat-

ImeGF

Hi

Maxim

for two special amenab-

Mr

this grant, I haw new
Following mvim of the work
employed an additicml Research Assistant who is helping us write
up mob of the information. while I have bun able to supply all

may Wur-

the Pamtho offiaa fumitm, files. etc...
rm funds of($00)
for
daticn, I would 111m permission to mmhaao a
he:- mo.
As in mum years, I ahmld like to
the results
of than studies at m mating of m CIR? to be held in Birming-

pmt

May I have permission to use am
80pm,to19613.
England (Waugh? $500)?

ham, Englmd in
of those ﬁnish, for

m1

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                    <text>Mitch 17. 1964

Raf:

IKE-30F

K6¢Ma~22, 572~01

Hr. Philip Suptr. Chief
Rananrnh Grants and Fullauahips attach

Hatianal Inatituto of Hintal Kaalth

of ﬁnaleh,'£du¢ation. and Vulture
Bahama. Haryland

Dupnrnnunc

”(It

Hr. ﬁapir:

aunt tuna, of anemia, of my knan dttappoiatnoat
that the eouulttua has not btcn ‘bll 85 recommend
this nppltcattan tor support. Thu burden: of ustablinking chi: rusenreh facility hsvu been great, ¢nd
this aqcaod eh: nos: ruanounbla way to racurn to the

You

IMEIMEIVD

In aha twant that taapplicatton sucks feasible, 1:
halpiul to h¢v¢ any information that the
Puhlte ﬁnalth $urvtaa any talent: regarding thn
countagcu's canatdcrattou, a: ordinarily may ha includné in uh: ”pink about”.

would ha

Thank yau

vtry

nuah

to:

your contidarutien.

Sincaroly ynura,
M”

’1“.

Ex¢¢ut1vo

um»
cc: Dr. Gnargc

A.

913::

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SCHOOL OF MEDICINE
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Mr.

Phillip Sapir

Chief, Research Grants Bmch
Natimal Institute of mm- Health
Bethesda. Huxylmd
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                    <text>Tim

C"

',
F,-

a
“a.

“macho,

July 29, 1970
Mr.

Saratella

Xerox Corporation
New York, New York

Saratella:

Dear Mr.

I am sending you seven books of computer data to be
photocopied and bound. As you described, they are each to
be bound on the tap edge, like the data book. As I need
different numbers of copies for each book, please noteza
4 Drug

Stony Regression Analysis

Thiothixene Prolonged Studies

—

~ 5

3

capies

Tniotnixane Study Regression Analysis

-

~

2

copies

Placebo

~

5

copies

PCP 250 mg

~

3

copies

75 mg

~

2

copios

S

GP

4 mg

—

I would like to
possible.

capies
~ 3

copies

have these picked up Friday afternoon

Sincerely yours,
Max

Fink; M.D.

Professor of Psychiatry

MF:kt

,

if at all

�</text>
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                    <text>September 17, 1970
Dr. G. J. Sarwer-Foner
613 Cote St. Antoine Rd.
Montreal 217, Quebec
Canada
Dear Gerry,

Since returning from Europe, I have been swamped by reports
due and projects in distress, and find that I cannot attend the
October meeting. Knowing your history, the meeting will be a fine
one and I will regret not having participated.
My

best regards,

and I

trust

I

will see

you in the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

fall.

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                    <text>July 1,

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best mamas.

Simuly your-s,
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14.1).

measaor of Psychiatry

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                    <text>Number 20,

Gerald J.
613 Cote

21.13.
SWFmer,
Antoine Road

St.

Emma,

PoQo

.

1961}

'

‘

Dear Jerry:

delimted that Don has sent you the Chlomxunazinh
paper- for ﬂamsim at the Research Momma
Inwtﬁutmmmldyouﬁmtthismpoz‘t
infamy.
to publish the proceedings
is new in press no that if youplan
as you have done hometown, it wcmld be necessary to indicate
that this has already appemd.
Mymntmvelscmdules fwmxtyaarhmnatyut

I

am

.

r

czyatalized,

'

soﬂntIdonotmiromattmdﬂwmthg.

mwaritetoywewlyinJmu/axyiflamabletojoin?
Mybestwishas forasuooasaful mama, and forthe'
Newman

'

-

_

Sinmlyyom,
Max

Fink,

Erector

Inf/18

c.c.

Dr. Donald

main

M.D.
,

�</text>
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                    <text>Deoenber' 31, 196k

J. Sarwerhfmer, M.D.
St.. Antoine Road

Gerald

613 Cote

Montreal 6. P.Q.
Dear Jerry:

I

have read your proposed program with considerable
interest and believe this will be an excellent meeting.
At the present went, however,
is
a toss-up as
to whetiwr I will be able to attend.

it

still

However,

'

I noted with pleasure that you have listed
our phenothiazine treatment of depressicn as one of the re—
ports. I called Don Klein yesterday to indicate that this
report

you an

willbein
alternate

inJanuary and urgedhimto send
and perhaps an inverted set of authors

so that he could present some of his more recent data, com
firmng these earlier observations. I would be embarrassed
if this report were listed as being read, since it will appear
in the public press during Jmuary. Please alter the title
and the authorship to reflect his wishes.
My best wishes for the New Year.
Sincerely yours,
Max

Fink,

Director

M.D.

�</text>
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                    <text>November 18 , 1966

Dr. Gemld

J.

Sarawak-Former

Cote St. Antoine Road
Montreal 6, Quebec
613

Canada

DearGerry,

I have held your letter of July 13, 1966.311 this time
hoping the CPA] mlement would find its way to me. It

hasn'tandemldbegmtefulifywmuldeendmamﬂmr
copy

to the present address.

I

have recently seen Paul Rajotte. He appears interested

inmtmningtcNewYork.‘ ﬁxewcrkhemhaebeengcingvery
I am excited that we have received excellent support
from the calamity, funding agencies and the established staff.
Ifycuareplaming to attend mofthemeetinge inNewYork

well and

in

December,
My

I

would be pleased

to see

you.

best regaxﬂs.
Sincerely yams,
Pink, M.D.
Professor of

Hex

1!!ka

Wm

�</text>
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Salon,
Professor of

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t

3181. 8.9). San

1965

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Park
Jmm
97201

Portland. Guam

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Road

Darker-gs:

Impmdmmomseapmﬁntcfm
ﬂmmwmsmtyofaiologioalhydﬂam. A11
manmimlud-dmitmyhemmmmroryw
atﬂxistimﬁnnmitingforﬂmmprdntwbichmywt
beamihblcforayaar.

ﬁrmly yours,
Max

Pink,

M.

D.

Professor 0: Psychiatry

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                    <text>my 20.

1965

Saslow, H. D.

Professor of Psydﬁatzy
of Ouegcn Hedieal School
{hivevsity
1: of Psychiatry
3181 SM. Sm Jackson Park Road
Portland, Dream 97201
0931‘ George:

I

am

pleased to enclose a pmpr-int of the presenta-

timmdetotheSocietyofBiologicalPaychiatry. A11
mania includodenditmaybemhelpml forym

atﬁmisﬁmﬂnnwaitingforttwmpﬂntwhichmymt
be available

for

a.

year.

Sincerely
Max

Pink,

New
melon“

yam,
M.

‘

D.

of Psydxiatxy

�</text>
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                    <text>September 5, l967
Dr. James H. Satterfield
Gateways Hospital
189l Effie Street
Los Angeles, California 90026
Dear Jim,

pleased to receive your letter for I have known of
Gateways Hospital for some years and am delighted that this
fine institution will have your support. Knowing of its
similarity to Hillside Hospital, I was pleased to discuss the
development of research programs with the Ziskinds on many
occasions during the past few years and was most encouraged
by their forward looking point of_view. Good luck!
I was

I am pleased to enclose a few of the available preprints
of studies recently completed. This work was done at the
Missouri Institute of Psychiatry using the IBM l7l0 a l620

system which

I

established there.

I do not know of anyone using a link computer successfully
in the analysis of EEG signals except its widespread use for

averaging evoked potentials.

Please give

my

next you see them.

personal regards to both the Ziskinds when

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>aw-.w, WWW," .-. ___,,_,

r.

NF

...

.v

., .,. ‘-kmnwrrwvw'.rvw‘_WWW-N'

.

'mmm

Sebtembék 5, 1§67

‘

Dr. deﬁes H;

Satterfieid

:theways Hespitai

7
1891 Effie Street
Los Angeies; California 90026
’

h

.

Dear Jim,~

I was pleased t9 receive your letter far I have knewn ef‘
Gateways HQSpita1_for some years and'am daiighteé that this
fine institutien wiii have your suppart.r Knowing of its

‘

-"

similarity_tQIHi}iside Hospita}, I-was pieased to discuss the
deveiopment of research programs with the Ziskinds on many
occasiQns during the past fﬁw years and was mast enccuraged
by their forward iocking point 9f View; 509$ luck!
I am pleased t6 ehcibse a few of the availabie preprints
of studies recently compietad. This work was done at the
Missouri Institute of Psychiatry using the 18% 1710'~ 1620.
-

&lt;

system which I estabiished

there...

I do nct know of
.
anyene usiﬁg t iink computer succeésfuiiy
in the anaiysis of EEG signals except itS'RideSstad use for

averaging evoked vetentiaIS;

,

"

'

Please give my persenal'regards to Seth ihe Ziskinds
next you see them;

when

.Sinéereiy yearsg.
.%ax¢Fink,*%.2§.

Professor cf Psychiatry‘

:Mﬁfkp

�</text>
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                    <text>May

11, 1978

Paul Satz, Ph.D.
Department of Psychology

University of Florida
Gainesville, Blorida
Dear Paul,

I have had the time to read your interesting report
it should be published. While I would consider the
standard neuropsychological journals, I will suggest that you may
want to place it in a journal dedicated to drug problems such as
"Contemporary Drug Problems". The audience is the legal profession and
those sophisticated drug research specialists who have an interest in
behavioral variables. I have published in the journal on a number of
occasions and know the editors, who would (I think) be interested in
the review. (Laurence London, 2” West Terrace Road, Great Neck, NY
and do

believe

11021).

I found the summaries of the studies well done and
the report interesting. If I were to critique the Greek summary (since
I know it best), it would be to indicate that we dedicated a lot more
effort to the EEG testing and it was this component which complements
the other brain tests in other studies. The translation of the EEG
data is not too difficult—— we found that the resting BEG records
of users and controls were the same; that the effects of cannabis,
even in high doses, altered the EEG patterns transiently; that the
patterns were similar to the effects of acute use in lower doses, but
lasted longer. However, when the EEG records were examined after a few
days of abstinence, no abnormalities or drug effects were left. In sum,
cannabis produced a transient CNS effect (toxic psychdsis in a technical
sense) whcih had no long lasting component. Similar to the psychologic
tests. The very absence of the findings in our study, and in the other
studies is the remarkable fact. Like the stony by Conan Doyle, the
significance of the dog's not barking was the critical clue-- the
absence of neurologic and neuropsychologic effects is the important clue.
You could emphasize these more.
Thanks

for the chance to read the review.

Good

Sincerely yours,
Max

Pink,

M.D.

lucﬁ.

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                    <text>.4

‘2‘.

October 28, 1986
Dr. Heinrich Sauer

Psychiatrhcbe Universitltsklinlk
Vow-8m 4
6900 Heidelberg
Federal Republic of Germany
Dear Dr. Sauer,
In your

cite a report by C. Ernst
1396-1405, 1982. attempted to obtain thk article from

abstract for the

1986 CINP meeting, you

in Schweiz. Arzteztg. :49:
our library, and have been unable to do no.

I

Would it be possible for you to send me a copy of the

complete citation?

article and the

Many thanks. My regards.

Sincerely yours,

Max Pink, M.D.

Profemor of Psychiatry

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                    <text>May

Ir.

23, 1953

Michael G. Saunders

Pmsident, Central Association
of Electrommphalogmphwn

The Wimipeg Gunmetal Hospital
700 William

Winnipeg 3,

Amue
mnitoba,

Chanda

DaarMiko:

web for the invitation to maniac a meeting for
the OuntmlEEGSociety. Asyoukzww, Imammmerto St. Louis
and before accepting your invitatian I took the opportunity to discuss
it with Dr. O'Leary. He had some
suggestions. the chief of
which was to imuim as to the feasibility of balding a joint mating
with the Eastern EEG Society. Befom going ahead, I )mnder if you
would be willing to inquire frm the President of the Eastern EEG
Society as to the fusibility of such a joint meeting, and if so,
whether they would like to establish a joint program
Thank you very

mum

I have never attended a meeting of the EEG Society, so I do not
hmthegmmlmngeofintomst. As Ihawmado some inquiries
have I havc bean talc! that most of the when are clinical electmo
and that a pmgzmn with
on neurophysioloy
oranimal studios muldpmbablymtbeasmlmasmebaaadm
clinical and office E36. 18 this your impmsion 0f the Society?

WWW

Pleaaa advise me.

Wis

My

best mgards.
Sincerely yours,

m

MPzaw

Pink,
Mmetm‘

M. D.

\
\.

\
K

�</text>
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                    <text>July 25,

Br. Michael B.

1963

Smdem

The Winnipeg General Hospital

Department
Wampum}:
700 William Manna
Wimxipag 3. Manitoba
Canada
.

warlike:
Following your letters I not with Dm. O'Leary and Landau on
om occasim; and lately with 13m. Joyce Small, Robert Wolsey. and
Tumn 11:11. to discuss the next mating of the Central EEG.

w 17 am iwmctioal, imofar
have
been held. Secondly, the
will
just
Moan mating
Insti'mm laboratwies will not be opemtimal. Bliss would not be
in a position to be host as that institutim will be undergoing conThe suggested

as tho

dates of

EEG

November 10

structim.

Hard:

For

or

this mason,

mid Febnmxy.

we

would suggest the

mating be held in early

If this is awable, is it your wish to have
committee

:Vinbem

sex

the St. howls
as well as mungenm-ts? Also.

act as program

(1) Usual umber of
(2) 2 or 3 days?
(3) who prints
(it) Who plans

mgswmm

mm,
de'

mailing, «0.?
affairs?

If a mating must be held in Nmmbor. than
to find an alternate host im‘dtution.
‘

it would be necessm

Phase advise. mania.
Sincerely yours,
“a“ Pink.
Niki!»

plum

Dimctor

”0 Do

�</text>
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                    <text>7.

”ﬂy-.w-wu—xw-v-u-

1..-

—-V

..

.&lt;

March 5, 1971
Mr. Richard

Scsrpellino

General Foods Technical Center
Tarrytown, New York
Dear Mr.

Scarpellino:

Dr. Arthur Zaks of our College has delivered 240 cc of
Narcan (naloxone) concentrate (100 mg/ml). This is to authorize

your experiments in improving the

taste of the material. We hold
the necessary federal and state authorizations for the study of
naloxone, and this request is sufficient to allow your studies on
our behalf.

We request the return of unused material and an acknowledgment
of the amount used for our research purposes.

.0...

Thank you

for your efforts.
Sincerely yours,

WWW—W‘WWWW.

WWNVIIMWW

‘I'rm’u-

WW

Hex Fink, H.D.

Professor of Psychiatry

MF:kt

cc: Walter Schulok

Michael T. McGuire

Jacob,

R. Feldman

�</text>
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                    <text>June 30, 1986
Charles B. Schaﬂer, MD.
and Linda C. Schaﬂer, M.D.
711 University Avenue
Sacramento, California 95825
Dear Linda and Charles,
It was a pleasure having you visit with us this past week. This note is to
conﬁrm that you attended three ECT treatment sessions on June 23, 25 and 27;
observed and participated in the treatment of at least 10 patients; made rounds on
our in-patient unit; and spent more than six hours in discussion with my associates,
Drs. Greenberg and Gujavarty our research nurse, Mrs. Carasiti, and our attending
anesthesiologist. Discussions included reviews 01 present treatment practices,
indications, consent procedures, anesthesia, monitoring, complications and their
management, and the features of three of the ECT instruments (Thymatron,
MECTA, Medcraft).
I

trust the experience was useful. Good luck in your work.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>July 7.

1978

Dr. Gunther Schenk
Essen, Germany
Dear Gunther,

I received your letter this afternoon, Just as I was preparing
to leave for Vienna for the CINP meetings and for Deals. I am writing
this note now to tell you that, in principal, I am sympathetic to your
project and.will do what I can to encourage you. But before I write
a letter about the project, I really must know more about it. I already
know about your ability (which is very high) but a letter in general
terms can do little to help.
In any case, to do the project Justice, I would like to discuss
with you in Basle. We should have some time together,apdrticularly
to discuss the nature of the work you propose.

it

ﬁbula it be possible to have an official request for a review
of the proposal 7 In the U.S., we often send proposals to gg,hgg ’expert'
reviewers for their opinions, particularly when committees may not have
the necessary expertise to give the application a satisfaetory review.
(I have done this often). The advantage of an official request would
be that the reply would be confidential to the committee and would

therefore be given

much more weight

in their deliberations.

I look forward to seeing you in Basle.

My

best.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>‘

ﬁé/ﬁm‘hm

”September 28 , 1978
Dear Gunther,

I regret that

did not find the time in Vienna or Sasle
to go over your program in detail, so I have had to write a more general
letter than perhaps is needed to convince a committee to give its
support. However, I have written the recommendation as strongly as
I could, and I hope it is helpful.
As

I

we

have been on the grant giving end of

things for a

number

not sure that such testimonials are very helpful. It is
still best for the commission to enquire of consultants, on a confidential
basis, for the advice of consultants. Perhaps they have already done that.
of years, I

My

am

best regards.
Sincerely yours,
.Max Fink, M.D.

Professor of Psychiatry

~

24'-

“am-“V

rm::v-'mwv.-,-v.-»-v.vm—

:
&lt;

r,"-

urn-w

swat

"-

70*“

a,~
farm

/

�</text>
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                    <text>T
m

June 18, 1971
Dr. Jordan Scher, Director
The National Council on Drug Abuse
8 S. Michigan Ave., Suite 310
Chicago, Illinois 60603
Dear Dr. Schcr:

for your kind thoughts and nomination. While
I
in accord with the principles of the Council, I regret
that I have neither the time nor the energy to take on another
am

Thank you

committmont, and must decline your

In passing, I believe

invitation.

much can be done

to reduce the

particularly with the narcotic antagonists.
I would commend your attention to those substances as therapeutic
agents for addicted at all ages and as a prOphylectic agent.
Good luck in your efforts!
Opiate epidemic,

Sincerely yours,
Fink, £1.13.
Professor of Psychiatry
Max

ﬁrst:

�</text>
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                    <text>April 5, 1991

Ms. Rita Scheman

Raven Press
1185 Avenue of the Americas
New York City 10036

Dear Rita,
am responding to your request for advice regarding the publication
of the 1990 ACNP Satellite Conference proceedings on the development of new
antipsychotic medications. am well acquainted with the organizers of the
meeting and with most of the participants. believe that this symposium was
Sandoz-supported (possibly with contributions from other drug manufacturers).
As such, the main thrust was an exposure by laboratory researchers of their
newest putative antipsychotic entities. These substances have been selected for
their similarities in pharmacology to that of clozapine, which is being touted as a
major advance in psychopharmacology [which it is not].
I

I

I

As is generally true for such proceedings, the better material will be
published in refereed journals; the material in the book will be either re-hashes
or so preliminary that it would usually not pass muster before responsible

editors.

To answer your specific queries:
1.

no comment

2. No.

3. Yes.
4. No.

It is not clear from the outline for whom such a book would be
intended. Libraries are cutting back on their purchases, and if were asked by
my librarian, would surely not approve the purchase of such a melange.
Especially, if had to choose between such books and journal subscriptions (as
have been asked each of the past two years). presume the main market is
the researchers themselves (and their mothers) and industry libraries. Such a
market seems limited, and such a book will probably require considerable
subvention.
I

I

I

l

I

�Ms. Rita

Scheman

Page 2

Two attitudes regarding publication seem reasonable.
A non-judgmental attitude would argue that

such preliminary material

may stimulate research and eventually lead to new drug therapies. But the
critical publisher would know that the best material, the most illuminating and
stimulating, will be published in the main journals, and that nothing will be lost
by denying this publication in a book form, with limited distribution and limited
(to no) indexing.

A more cynical attitude may also be taken. Since

these articles were

selected with the support and encouragement of the pharmaceutical industry,
and since the industry will gain the most benefit from such a book [they will
surely peddle it to the FDA and their Boards of Directors as evidence of
’scientific’ validity], there is no reason why Raven Press should not publish the
book provided the industry guarantees the purchase of sufficient copies for
their use and distribution, or a sufficient subvention to justify this type of selfadulatory and limited interest publication.
I

trust these comments are helpful. My best regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>~m-r-swmm v arm-V.—n- u v ﬁvm‘x

November 23, 1970
The Honorable James H. Scheuer

House of Representatives
Washington, D.C.

Dear Congressman Scheuer:
and concern of the attendees at the Michigan
methadone
was obvious. Your question, that of
conference in
methadone
available to your constituents
assistance in making
with
my associates, and they concur
discussed
was
in the Bronx,
The

interest

in the sense of our discussion: support for the further
development of the narcotic antagonists in exchange for

methadone guidance.

on my desk,
Addiction
Narcotic
York
State
which I
which
and
optimism)
with
Commission
(although
little
Control
would be suitable for support.

I

It

have two

useful proposals for antagonists

plan to send to the
was

New

stimulating to discuss the addiction problem.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

nf:kt

�</text>
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                    <text>September 11, 1993
Mr. Ivan Schick
ElCoT
14 East 60th Street; Suite 1207
New York, NY. 10022

Dear Ivan,
I had a very ﬁne lunch with Dick Glabers and Bob Ewing (we met at the Mirabelle,
our **** restaurant near my home). Their questions were mainly about the present status
of ECT as a practice; the impact of health care changes on ECT practice; the relative
strengths [and weaknesses] of the present devices and their manufacturers, and the [my]
experience with the ElCoT devices. I do not know whether I was of some help to them (or
to you), but we did agree that if another device were to come to market, the manufacturer
(or the manufacturers together) would probably need to develop an educational program
for both psychiatrists, generalists, and the public on ECT in order to expand the market
for ECT devices.

In any case, we missed you. Call me when you return from Turkey and we can
discuss their ideas.
My best regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>Department of Psychiatry

September 17, 1972

Gerold L. Schiebler, M.D.
Chairman, Psychiatry Search Committee
Prof. &amp; Chairman, Department of Pediatrics

University of Florida
Gainesville, Florida

32601

Dear Prof. Schiebler,

Like every man who has established a laboratory and seen
have thought of the opportunities in developing a Department
of Psychiatry. Finding the working and living arrangemnets in the city
too hazardous, I recently moved my laboratory to SUNY—Stony Brook; but
I am still interested in a Department.

it

grow,

I

I am pleased to enclose my curriculum vitae
for your committee's consideration.

and bibliography

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>April 5, 1966

Sabine
Em
of
meuaor Psychiatry
Dr.

Lhivemity of Minnesota

W113, mm

MM,

Immofulforﬂuopportmitytodinmswpmm
It
giwsmyutplmmtoundyoumpieaofﬂmemporm
which
which
the extent
may have bun muted
ofowmmﬂziapmgrm.
animatiaammhicmview
'IhoIm
“ﬂmmmmimlpmmformrmlym.
Symoaim mm tells of m of the applicatima. I». Itil's
mvicwofdolizdmshawaﬂuuaetomiohfmqmncymdyur
nthawhaenputinmmamdypmm.
"mmwnuxhymnphmmlog"withyouinﬂuhingtm.

mm

Ihopeﬁmtmmlesmrnlpful.
Sinoanly
Hm:

yam,

Fink. H.D.

Professor of Psychiatry

1mm;

enclosures

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                    <text>awn-v

r—ﬂ'www‘vﬂw’u‘-

:- w~

up“

",—

Ww-W'...

wrww‘

mvv‘n'rnmmw-nw-WICI'rWI—v

”mv

W'v-nnnwrwrm-"j

r."

w,

mv‘w‘

March 22, 1971
Dr. Burtrum Schiclc
‘w-v

77 Barton Avenue

ﬁinneapolis, Minnesota

-'r--;w-r1~r

'-

“.mrlum‘d

-

Dear Burt,
A few months ago I completed the enclosed technical report
on the present state of the EEG program for psychopharmacology.
My

mvpvvm-

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

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                    <text>March 22, 1971

Dr. Bartram Schiclc
77

Burton Avnnuo

Minncapolis, Hinncsotc
Door

Burt,

WWW.

A

WI-

‘

fcw months ago

on the proton:
My

state

I completed tho enclosed technical report
of the EEG program for psychopharaccology.

best regards.
Sinccrcly yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkt

�</text>
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                    <text>June 26, 1967
Dr. Bummn C. Schiele

Professor of Psychiatry
Department of Psychiatry 8 Neurology
Univemity of Minnesota Medical School

W113, Mﬁnmsota 55%5
Dear Burt,

mat know I enjoyed the recollections of your Eastm
tourverymoh; andanwritingtoaskﬂmtympoxmitmeto
homo»: your Istanbul slides so that I might have a few from
Bakfrkfy copied. I will return the set pranptly.
You

A

a
Many

thanks.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>August 22, 1967
Dr. Burtzun C. Schiele

Professor of Psychiatry

Department of Psychiatry

8

Naumlogy

University of Iﬁmesota Medical School

Iﬁmeapolis, Minnesota

551455

Dear Burt,
Thank you very much for the slides of Istanbul. I have
them
had
mpied and I am most grateful that you have given me
an opportunity to augnent my slide collection. As I told you
before , I very much enjoyed your travelogue.

Again,

my

thanks .
Sinoemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>January 16. l968
Dr. Burtrum C. Schiele

Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,

It

was a

My

best regards.

Friday. The discussions
of the Sugermen proposal suggested that draft copies of my recent
reports be made available. I am pleased to enclose copies of the
reports prepared for the ACNP. These still require editing, but
they do describe our present view of EEG, drugs and behavior.
pleasure being with you

on

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

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                    <text>June 6, l968
Dr. Burtrum C. Schiele
Professor of Psychiatry
Department of Psychiatry and Neurology
University of Minnesota Medical School

Minneapolis, Minnesota 55455
Dear Burt,

I have Just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric Journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>June 6, l968
Dr. Burtrum C. Schiele

Professor of Psychiatry

Department of Psychiatry and Neurology
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dear Burt,
I have just spoken to Joe Bird and since no meeting of
the investigators of cyclazocine is being planned for June,
I am suggesting that perhaps we can get togehter during the
ECDEU meetings on June 24-25.
In the meantime I am enclosing
the prepublication copies of the two reports from this and
Dr. Itil's laboratory which will be completed in the next few
weeks and sent to a psychiatric journal.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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“(Ivar-V

"VLW

—-—,—

mu
..
.A.

'lmﬁmr'wm

um-

m.

March

25,

1969

Dr. Burtrum Schiele

Department of Psychiatry
University of Minnesota
Minneapolis. Minnesota
Dear Burt:

is a draft cony of our report as submitted to
Phanmacology and Thenapeuxicb.

Enclosed

Clinicat

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

'rw:

‘r-W'W'Ir"ya

�</text>
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                    <text>March

25,

1969

Dr. Burtrum Schiele
Department of Psychiatry
University of Minnesota
Minneapoiis, Minnesota
Dear Burt:
copy of our report as submitted to
and
Phanmacozogy
Thenapeuzicb.

Enclosed

Clinical

is

a

draft

Sincereiy yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March 2a, 1969

Dr. Burt Schiele
Department of Psychiatry
University of Minnesota
Mixmeapolis, l‘ﬁnnesota
Dear Burt,

I have just received the

1969 program

of the

American

announcing the
Society of Clinical Pharmacology and Chamﬂmerapy
know
we are
You
report of cyclazocine as an antidepressant.
read a copy
to
Is
possible
data.
very much interested in your

it

of the data tables?
Many

thanks.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>December 30, 1982
Joseph Schildkraut, M.D.
Massachusetts Mental Health Center
74 Fenwood Road
Boston, MA 02115
Dear Joe,

Congratulations on your appointment as editor of the Journal 9!;
Psychiatric gesearch. It must be a good challenge to direct an ongoing enterprise,
and I am confident that you and Merton will work hard to maintain its reputation.
Your invitation to ‘share views about growing points in psychiatric
research, as well as areas not well covered by other journals' stimulates my reply.
Convulsive therapy remains an active treatment in psychiatry. In 1984, it will have
been used for 50 years -- a remarkable longevity when we consider that the
average half-life of medical treatments is much shorter. In the 1940's and 1950‘s,
there was the Electroshock Research Association which focussed issues about ECT,
and they published their annual proceedings in Confinia Neurologica. When that
association was prematurely digested by the Society of Biological Psychiatry in the
mid-1960's, the central focus ended. Of course, we expected the treatment to be
replaced by drugs. But that has not happened.
There is a significant gap. No journal and no society has taken the
leadership as a focus for convulsive therapy research. As a consequence, the papers
are scattered. Recently, i did a survey of the Medline citations under
'electroconvulsive therapy', and the attached data resulted.
ECT is an important treatment of depression. Indeed, I cannot see how
any research into the mode of action of antidepressants or the pathophysiology of
depressive illness can ignore the ECT process.
Considering your fling into convulsive therapy research, perhaps you and
your co—editor would want to consider a trial period in which you would establish a
section on ECT and invite review papers, conference reports, etc. My estimate of
the literature is a publication rate of 11 papers/month and increasing.
My

best wishes for your and the Journal's success.
Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>{

/

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v.7,

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wurupw

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War 1' 1

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Schilling

Innis, Missouri 63109

I

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nadyourlattor of Octobur 25, with intamt. While
you with regard ta mommdations
offaxmoo—woxkora,ﬁnfewwhomminpmctimmmtin
have

I mad be pleased to

3t.LouiabutianYoxk. MnyIsuggestthatyouhavoymr

Wursuabyymfmﬂyphyddmmdifmmdmllm.l

Whaphmdtodiamhiaobsmatimsmdpeﬁupsmkem

Wmmtywnquest.

Sincerely yours ,
Pink, PM).
Professor of Psychiatry

Max

"hkp

�</text>
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                    <text>September 2, 1970
Dr. John L. Schimel, Editor

Career Directions

40 Gramercy Park North
York, New York 10010

New

Dear Dr. Schimelz

Enclosod is a corrected capy of the summary "Toward A
Rational Theory of Behavior". I regret that the previous
copy which was submitted hurriedly had many errors.
I

trult this

new

draft is satisfactory.
Sincerely yours,
Max

mm,

mm.

Professor of Psychiatry

MF:kt
011C.

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Schlcmr
War
ms East 57th Strut
New

York.

Haw

York 10022

mum:
0n Jammy 31, we mm a 15.31th No. N5~5-3ul128,
Ihmmiwdammindicating
ammmwdbmspm.
mtlhavoadurgammt,butwahavemtmaaivadtm
clock. Wouldyoupleasa mamms mmt, acopyofwhidz
18 MM?
Simmly yams ,
Max

Fink, NJ).

Professor of Psychiatry

�</text>
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                    <text>amm—r—WW

'm

1%

New—T

-

mm

Merch 28, 1978
Mr. Jacob R.

Schlenger, Secretary

Research Foundation for Mental Hygiene, Inc.
hh Holland Avenue
Albany, New York 12229
Dear Hr. Schlesinger,
Thank you for the notice of election of March 6, 1978.
I regret that my committments for the coming year preclude my
active participation in this worthy effort, and I am writing to

decline the election.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Mex

cc: 8. F. Yollee,

M.D.

�</text>
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                    <text>..-

.77..—

.ﬂ

...=

,, _,_

—_r.~_a.-r"~_.nv ,.

7.,

_

"—1.? “v.

w

'1‘ “H W.

.

.7 ”amuucv—n‘ ,Shnwi_ iv .WV .7

\

,c

January 22. 1975_
Steven Schloasberg,

Janssen

R

&amp;

501 George

New

D,

Inc.

Street

Brunswick,

New

M. D.

Jersey

08903

Dear Stgve:

.vn

(«hi—v.7"

.Congratulations on your new position. From my know—
ledge of Paul Janssen and his teams, you will be kept busy with
interesting and novel ideas. My Bast contact with Janssen R a
was with regurd to tho central effects of an anti—helminthic
with presumed antidepressant qualities - tetramasole(?). What
did happen to it?
My

1..

best regards.

an"

Sincerely yours,

7*

.7.

lmuu"!-«1::~.'V".‘~xr

Fink, M. D.
Professor of Psychiutry

Max
-

maﬁa-"1:

..

v.»

”an-mum.

vwmrwvww‘

A

Merd

D

�</text>
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                    <text>Mitch 29. 1965

Esther H. Schmidt
Resident Manager

Thu Grand Towars Apartmnntl
3520 Laclcdc Axnnue, Apt. 707

St. Louiu. Histaurt

63103

Dun: Endan:

During 1963 81:: Gasparovic.wns employed by the Missouri
Institutc of Pnychiatry an a rotaareh nurse.
During but work hora sh. exhibitad a grant deal of
intogrtty. hounaty and responsibility. In my dealings
with her I had no occcaiou to qunutton hat honesty,
and I vauld rheolunnd but without question.

Sincerely yours.
Fink. H. D.
Profaanor of Psychiatry

Mn:

Hrzkp

�</text>
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                    <text>May

Dr.

meis 0.

10, 1965

Schnitt, madman

Nemciencos Ream ngrmn
280 Newton Street
Bmdclim, Haasaohmam

021%

{bar Dr. Schnitt:
Your

presentation before the Society of Biological

Psychiatzymmoofﬁxemat inspiringandmaxding
ﬂutlhaveheam Pollmingﬁmmting,10btaineda

oopyoftheNRPBulletin, Velma 2, NW5. mdhavetakan
ﬂielihcrtyofpmsmtingthistothonbmyofﬂissm
Inatituto of Psychiatry.

I

would be

grateful

if we

could receive an

earlier

copy

ofﬂmNRPmnetin,mdifIcmﬂdbeincludedinyourmiHng
lint.
Wmmymchfomymmooopemtion.
Sinmmly yam-s,
Max
HF:

jm

Pink, H.D.

Hofessar of Paydaiatry

�</text>
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                    <text>‘ﬁw:,yv'maw1ulﬁ

v-m.

--

‘IA-«rra'mw

w...

A

ww

'"an

w,

,

V’iwmmnw-m

.
__,_n

January 31. 1969

r

.

new-mm

vr-

"‘VIW'JJV'E'

I'M!"

_

Dr. Max Schnack

Department of Clinical Pharmacology
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Schneck:

-g"mv-wr-,¢V,.u.,,m.

Ir—r“

"‘

I

It

‘1‘lfiﬂ’i'vo‘vWFVWEM-rrmix-Err

"n”:

""“‘""‘"“3"-

r1:

"a"???

Yaw-CV.

[WIFE

you about IPA 2443.
when
some evidence of
from you

chatting with

would be pleased to hear

its antinarcotic activity in

animals has been accumulated.

Enclosed is a summary of the EEG classification data
as well as two reports describing the specific application

to cyclazocine.
Thank you

for bringing this problem to

my

attention.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.
r.

WW'W'JN‘aw-r

was a pleasure

ﬁFskp

�</text>
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                    <text>February 3, 1970
Dr. A. M. Schneider
Departuznt of Psychology

University Callas:
Raw York University
Bronx, Kev York

Dear Dr. schnaider,

discussions in Aspen, and have
tried to ahara my notes with my asacciates. gay I aﬁk that you
send an capiao 0f ynur more recent reports an memory changes

I vary

and

cansolidatiun

much enjoyed your
?

Enciosed is the program of tha APPA which is maeting
1n Raw York February 13 and lé. $ome of the reporters era well
known and yen may enjey the presentations. I am encouragad ta invite
you to the cocktail party, and look ferward to welcoming ymu.

Sincerely yours,
Max

Fink, M.D.

Profaaaor of Psychiatry

mf/

�</text>
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                    <text>tv—xw

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WW
AOctober 16, 1975

M. Schneidor. Ph.D.
Senior Editor
Raven Press

Diane

Awenue of the America:
now York City 10036

llho

Dear Dr. Schneider,

I have never studied cocaine, and while I would be
follow
in the historic steps of Sigmund Freud, I cannot
to
delighted

do so.

My

present commitments are too

mneh

to beer as

it is.

I have not lbllqwed the latest cocaine literature, but
incidental.resding in the psychiatric Journals, I don't think
there's sufficient new infbrmntion to warrant even a systematic
review urticle on this very limited subject.
from my

nr

~i‘4'1/

Ira-7.,“th

to reed the volume put together by Dr. Eyck,
"cocaine Papers," published by Stonehill. Dr. Eyck is a well-trained
physician and he was unsble to put together a very useful volume.
A copy of my review of his book is enclosed.
You may wish

E'v'r-

Thank you

for thinking or

me.

Sincerely yours,

pr“;

.~

,

n«;.n

,
A

w

rrn

Fink, M. D.
Professor of Psychiatry

Mex

MA

32%

cm,

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                    <text>Hitch 5.

Hr. Raymond E. Schntocz
Vics Prlntdont. Soutkwnut Bank
2301 8. Kinsshighwuy Blvd..

St. Louis. Missouri

Duct Hr. SchntotI:
Encloond

is a

chuck

for $1,946.00 in payunnt for

the loctcr of crndit on hehllf 0! ch: ﬁan- Van Gogh
Anstardau Liberatory. Sltuncwog 11, Aﬂltltdll, Rnyou 18.
This 1: in prior paynnnt of the counarcial lattc: of
canal: ruqunazud on Hnrch 3rd in paynnnt for our order
#vnr 424.

Thank you

for your help.
Sincerely yearn,
Max

Fink. H.D.

Exacnttvu Director

u£;13

uncloouta

1965

�</text>
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                    <text>unav'ur'21,

&lt;

warm-—

July 14.

1964

Mr. Lee Schnnre
Elmer Fox and Company
230 South Beniston Avenue
St. Louis, Missouri 63105

n

rum-m

Deer Lee:
During the pest year. the Foundation has appointed a number
of employees from oversees. dome of whom have come to the
United States on an immigrant visa while others have come
as exchange students under P.L. 87~256. We hold exchange
student visa P-lI—3388. On behalf of a number of scientists.
we have filed Form I~140.
‘

Three men have recently been appointed. including Dre.
Alexander M. Don, Teknmi Iknta. and J. C. Holden. The first
two are on exchange student status, while the third is on
immigrant status. It has been brought to my attention that

the Federal taxation lows sppliceble to these men are different then those applicable to permanent residents of the United
States. Therefore, I would appreciate your obtaining all the
necessary documents from the Internal Revenue Service. review~

ing them, and providing the Foundation with a general statement
regarding the tax status so that we can be prepared to notify
these appointees as well es new appointees of their obligations.

important. perhaps. is that if there in a discriminatory
ten situation. I should like to bring this to the attention of
the Foundation IO that modifications may, if necessary, be made
in the stipends paid such candidates.

More

Thank you very much

for your cooperation.
Sincerely yours,
Hex

rink.

M. D.

Executive Director

MF/Jb

�</text>
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                    <text>February 23. 1965

Hr.

Lu Schnurc.

Elan:
230

to:

&amp;

CPA

Conpany

8. Boniaton

.CIayton. Mtlsouri
Duct Lou:

Insofar as tho administrative problems of this cantcr are now
in the hands of Mr. Thompson. I II sending the rosuan regarding
tn: dttfotuntiall tot forotaa scionttatn to him. A copy of :3
lcttar 13 enclolnd for your information.
Thank you vary much

for your coup-ration.
Sincerely yours,

at:
-

H?:jn

‘

Fink, um.
Exncutivu Dizcctor

�</text>
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1965

a. sum.
mama Blvd.

Mr.
7 sum:

St. 1min.

was:

CPA

mm

Whmimmryofﬂmequipmntmhmdas
01M. 1985,Wtbyfmdsofﬂn?aydxiatriom
memtamincludumgifta
martian-i.
'62, #3, us). Forﬁmitmmutimatod valueia
(1m
includod.
macamdofmmqtmofﬂmfmtimwoumm
oftho
tobavethesoim listedaapanof-tMassets
mdhave

and
mm,
themtqmly
fwmmtimmgudngﬁnpmpcrfminmid:
Fanatimin

«wallets mpmoodm for depmuiatim.
Iwouldbcphasedtohmmylomeymmuawith
whodcs
atthemdofﬂay. memxtmetingofﬂn

this timid!»
Pamdntim

done

W

foera a,

11h an int-rim £3.an

1965, mdwe muld

atatmt, at that tin.

Hazy thanks.

Sinaonly,
Max

MFij
Eml.

ﬁnk,

H.D.

Incentive Director

�</text>
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                    <text>.v,w...1.vAw..-u.--~v-

a.

w.

,

.wv

«,

;

\w~

3M w van-p m_-‘“u- rum-mv‘m

4nn-.V-Iv'--

V-

v

,-

~

_.‘~‘ may
»m,-mmu.w.m—w—r--,

._

.

.....~,- ~.

.

v...

“7“", r

.,..,.

.

....

Ely 5, 1978

Neil

B. Schofield, H.D.
Flaker Drive
Wykoff, N.J. o7u31
M16

Dear Dr. Schofield,
The question of fractures after ECT has not been
assessed recently. Neither in the Task Force Report nor in the many
recent reviews, has the issue been raised. Perhaps. because the
problem seems to have been solved by the introduction of succinylcholine. There are a number of studies assessing the impact of
succinylcholine on practice, but these appeared soon after the
first papers on the drug, about 1963. The ninth meeting of the
Electroshock Research Association in 1953 discussed the effects
in some deeail (Confinia Neurologica 132313 ff, 1953). Some reports
are cited by Kalinowsky and Hippius, but these are not well

documented.

The

best reports comparing modified

and unmodified ECT

are those of Havens (1958) and Huggins, Sandifer and Pearson (1969).
I would start with those as the baseefor any studies now.
I

am

sorry that I cannot be of more help, but the topic

has not been covered recently.
Good

luck.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry
Max

3‘:

.wnz;

w.»

.

�</text>
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                    <text>"'1

.September 16, 1977

“U

swnww'wr“‘

C.B. Schorer, H.D.

Lafayette Clinic
951 East Lafayette

Detroit,

“We

rmwsvﬂ.

Michigan

Dear Dr. Schorer,

—u.-mwr'

regarding

m.“

'7‘“.

'WIIV'V1W

mm&lt;

#8207

I

am pleased to respond to your request for information
association with Oliver Nikolovski, M.D.

my

Dr. Nikolovski was a clinician in the out-patient departments
of the Department of Psychiatry at the New York Medical College at a time
when I was Director-of the Division of Biological Psychiatry. Soon after
he joined the clinical staff, he sought me out to develop clinical research

projects.
ﬂew-M:

developed a number of studies together. I found him to be
a meticulous worker and he carried out the details of the protocols with
exactitude. He was reliable and thorough. He was liked by his aptients.
He taught resident psychiatrists the elements of
descriptive psychiatry
We

and

his reputation in this role

was good.

is a reliable worker who cartees out instructions well.
is neither innovative nor adventurous, and if he were placed in a
He

He
Inn—‘—ywj'Imum—"J_nwuu‘mmw.wwWI‘NWWT

position with specific missions,

the

staff.

I

trust these

he would be a most productive member of

comments are

helpful.
Sincerely yours,

'vw—m‘

,

-

.w

,

Max Fink, H.D.
.Professor of Psychiatry

�</text>
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                  <elementText elementTextId="102805">
                    <text>January l6, I969
Dr. Ger? J. Schuller
Asslsfanf Cllnlcal Research Dlrocfor
The Squlbb lnsllluTe for Medlcal Research
New Brunswick, New Jersey 08903
Dear Dr.
.

Avryrﬂvr'pw‘:

«w

Schuller:

Separafely am sendlng you our fllo coplos of lho
record absfracfs for each case In The fluphenazine docanoafo/
enanfhafo sludles; as well as a wrlfe-ouf of fhe laborafory
I

dafao

:wﬁr"?

The lndlvlduol case records Include coples of The summary,
and vlslf records for each paTlenf in +ho sfudy.

~

«xv-a»

raflng scales

The laborafory dafa book confolns the acfual dale reporfs

WWWW

for each subJocf, lo

The exlenf colloclod durlng The sfudy period.
of lhe laborafory dafo report ls a copy of our
standards and fhls oeflnes fho upper and lower llmlfs for Thls

The
strewn-1min

flrsf sheaf

loborafory.

“3w:

,
gar-a

tyrant-arm.-

Ho would appreciate return of the records as soon as you
have complofed your review. The laboratory data slafemenfs
are The orlglnals, run for you, and tholr rofurn ls no? necessary.

Slncorely yours,

w:m%w‘r;hﬁ'ﬂw

n~

main-:1

Max

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                    <text>April 11,
Dr. Gert

1969

J. Schulier

Assistant Ciinica] Research Director
The Squibb Institute for Medical Research
New

Brunswick, new Jersey 08903

Dear Dr. SchuIIer:

manuscript has been submitted to Dr. AIain Sanseigne
of Squibb International to be published as part of a volume
commemorating the meeting in Sitges. I have no other information
at the present time.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

A

M,

a.“

o
—

.:
.w
..
.
‘

'"W'"I&amp;'W""nr‘u

�</text>
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                    <text>Earth
Dr. {Bert

J.

13., 1969

Sici‘mllex‘

Assistant Clinical Research Bimctor
The. Squibb Institute for Medical Fﬁsam
New Bmmswiok, ﬂew Jersey 08903
Dear Dr. Schuller:
31-15:ka

you

disthinuim

study period.

for your inquiry regarding; the reason for
depot f1uphenazine in 22 patients during a
'

Fifteen {wtienta were disomtinued ltuecause of failmr'e
to keep appointmen‘m; of these, tl‘m'ee were imaznvec} , ten were
unimpmvec‘; and We had complained

of secondami effects .

Eight mtiemts cut of the fifteen haﬁ remix/12d l~~2
injectims mly, and. the regaining seven patients received
34»? injectt'ums.

patients were dischemg cm transfemed to other
fm‘ﬁf‘ﬁeatmnt by the ﬁnerapist; of these, two refused to
continue treatamt, time had secondary effects , mo of which
war»: hmyﬁtalized by other doctors , cm was; heapitalized fem
alcoholism, and another one was hospitalimd became of the
severity of his mmtal ccmditim.
Seven

.3

fmm patients were hospitalized. MG patients
were disomtinued because of toxic effects or physical

In

total,

mlicatims.

Sincemly yours ,
nun-wyww;

mu

.
r.

v

mm’w‘nmJ'l—Ir

Ptofessor of Psychiatry
Mszp

�</text>
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                    <text>October 17. 1963

Fini Sehulsinger.

Chief Physician

H.

13.

Psychiatric Clinic

Wpitalet

(Depenhaaen. Homeric

Dearf‘ini.

Ithasbeenalittlemthanayearsinoelvisitedmpen-

hem;mdalso,1havebeeninhissourialittleowrayaar.

Bjnou.

msmkeshouldhevemportedhadctoyou,end1hopeshsMsgiven
youapietmofoxmpromss.
Shehesbeenaverygoodnursemdwewemsmytomhergo.
we gave her one of our wards of abort 20 Lang-tom psychotic subjects.
In a few months, hermrdwas ”alive” - with the patients active. wide0.1”.

Patients on emther ward. organized at
make, and participating in
the am time, with a different staff muse, appeared withdrawn, quiet
mdinaotive. Bothwardshedtm samthempist. andhewas soon devoting me tin with Miss Deneke, largely because he felt more optimistic
with her patimts. After sane name. I had a problem ward. and asked
her to assume respomibility for it. She did this so well that this mp
now became our ”met” populetion. She
well liked by staff and patients
alike-— endespeciallyby maides mdatundmts, forﬂuomehem a good
leader. There was we problem in her stay she liked her patients so well.
and identified with than, that she beoam upset Men the patients were upset, and was elated when ewe did well. We miss her already and promised

m

‘

hermaminhnwtifmwishedtoretumforamtheryear.

Manythenks

formomndinghertom.endifothezswishtoependmtiuinthe
said candidates.
Statemhermoordwassegoodaetooeneeuetomlm

Why,
tothe

lebomtoxies in eleouoemepmlogmphy and
endthe oomtermit areal]. opemtingmll. I look toward
The

�Fini Schulsinger,

M.

October 17, 1963

Pam

D.

M

tim.ayearfmnow,whenveehmldheable toatartmportingdm.
0n the wards. my biggest problem is the classificatim of patients'
he in
War.
ficult; and the

&lt;3de
New

York,

I find the classificatim of patients very dif~

of the parameters of patients' change almost

mandible Thais. mtilItakeaverysimleappmadzmdmmelf
Momentum. Ihave
andwfellwstudenteeemmuringinstmnt.
become interested in Fritz
eiwle “tarmt 3mm” approach. After spending two years with factor analysis. Mathis-rate fmction analysis
and such Omar "salmi' tedmiquee. I am a bit disenchanted and believe that

W‘s

simhmmmydomformcmmlmmmmmmm

plex.

me?
anticipated mat soon new equipmnt for
is your study

I last discussed
wmldhemingin. Hasthiemrioedautwell?
How

When

it with you, you

Woman]. manna-ate

MWMM leot,Iettmdedﬁaeinericm£EGSociety

metingoinﬁmﬁancieoomtookﬂuthewiﬁxm. 'miemthefirst
melvamﬁmsimeomingtomsmimdwemjweditwrywch. I
lodcfmdtobrinmmtoﬁmepemxt mmrmdshouldliloe,on
that

mien, tommcmtwithyou again.
Ky heat maul regards.

Sincerely yours,
Fink,
m
mmtor

M.

D.

�</text>
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                    <text>July 23, 1964

lini

Sohulsingor.

Chief Physician

H. D.

Psychiotric Clinic

Konmonehospitalet
Copsnhagen, Bennett
Bear

Fini:

’

Another year seems to have rolled around. and we are just making
our plans for our summer vacation in conjunction with the psycho—
pharmacological meetings in Birmingham. I had hoped to be able
to visit Copenhagen this trip, but I find that my schaule is so
oomolicatod with business meetings in Tai.Awiv, Istanbul and in
England that I on going to have to forest the pleasure of meeting
with you. unless you and your friends will be attending the psyohopharmacological moorings.
The work here has gone along fairly wall, although I now realize
what others have said - that
takts two years after a move to
roostabliah a laboratory and tolloot meaningful data.” It has only
been dating the past few youth. the: I have been able to sit down
and review some of my work. lbo- lobotatories. however. are
functioning vosy wall. especially in neurophysiology, pharmacology,
and out eonputar tantet. Mostly. the work this year has been in
quantifying the EEG thangas with drugs, and tho methods appear

it

suitable in quantifying other analog signals such as GSR. We are
now applying this nethod to soon studies of barbiturate induced
changes in EEG, reaction time and behavioral change in a group of
long term psychotic subjects.~ This is part of one of our largest
evsloatioo of some of the factors which may lead to
programs——
long term hospitalization of the severe mentally ill.

it

ate continuing our studies of 826 changes. pneumoencophalogtams,
and neurology findings and associating these with the family hiototy.
and Sooial charaotoriating of our patient papulation. We are not

we

sophisticated enough. at present, to undertake the genetic study
future

which you are doing, but look forward to a time in the near
when such informatioo_will be added to our studies.
Den

'

of our senior soientista. Sam Gerahon, plans to be in Copenhagen
about the 5th or 6th of August. I am taking the liberty of suggest~
ins that he call you at your office and if you have the opportunity,

�"M
,-

wry...

My”.

-—.

Dr. Ftnl
7-23~64
Page Two

H

I

would

hollcvu

b. plansad to

it would

bu

the Kbmmunehospltalct. I
to see your wards, as
their being an especially v.11 super-

haw. him V181:

:tlunlaulng for

hhm

I was srnatly luprnsaad by
vised and unnagcd, and by ch. typa of care you 31v. you: patiants.
associates and I miss H13: Douche, whose aehievements her. were
quite good. I trust that she is happy and as succetsful 1n ha:

My

new

:nvironmnnt.

'

.A

w—n

w,

"Ir-Hm“

—u,-.——-

"mu

.nr

Il',»nr\-‘&lt;—)'m

Plano. :unnnbcr an to Hanna.

cVnryOna

can‘nakc

‘.

-.-...u...v~.

A

few

nights ago.

when Sam and

his

vita, Lill, ynre nt our homo and told us that they wart planning to
be in CopgnhagCn. Htrtha and I began to tell them of our pleasant
visits and bean got out th. guide banks, and 1t banana obvious to
my

that wt

it

had a-vnry pleasant
again soon.

ﬁlms

with you. I hope that w.

bag: parsonal regdrds.

"slncaruly yours.

-.

Fink,
Diroctor

Max

32th

M.

D;‘

�</text>
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