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                    <text>WEE

‘

mum—w

March 1, 1972

Dr. Arthur W. Increiter
March Sharp 6 Donna Rascarch LaboratorieWest Point, Pennsylvania 19486
Dear Dr.

Iacroltcr:

The supply of levomethadyl arrived safely w many thanks.
augment our studies by incraaaing the
nunbcr of subjects and the time. Our report is now in galley
for the JANA, and should Appear shortly.

We

will use this supply to
My

best regards.
Sincerely yours,
2h! Fink, Moi):
Professor of Psychiatry

mrzig

cc; Clyda Strickland, 3.0.

�</text>
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                    <text>February 28, 1972

Dr. Allan P. Berger:
Associate Director

Pfiur Inc.

Eastern Point Road
Grown, Connecticut 06340
RE:

Lithane

ERR 2/13/72

Dear Alan:

are most grateful for the supplica of Lithane (lithium
carbonate) which you so kindly made available to us in 1970. Silica
that time we have trested more than 20 patients, neatly those unifaring from mania, and the supplies are exhausted.
Re

Early in 1971, Lithane was approved by the fomulary courmlttee of ﬁetmpolitm Knapital Medical Center for psychiatric uses,
and is no longer "investigationnl" and not under out control.
Thank you

for your assistance.

ﬂy

best regards.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry
has:

�</text>
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                    <text>Februnry 28, 1972

Stanley Einstein, Ph.D.
Executive Director
Institute for the Study of

680 West End Avenue
Raw York, New York 10025

Drug

Addiction
’

Bear Stan:

Th: potential importance of the narcotic antagonists in
both the trcatmant and prophylaxis of opiate use should mako a pra~
scntttion of the availablc data a muttcr of high priority. While
I do not believn the College will bu able to find the travel coat.
for the misting, I could suggest you list my presentation and be~
tween us, we should be abla to find some solution. If not. the were
listing will, at lcast, give the possibilities some visibility. and
enhance the historical record of the meeting.
As a title: "Antagonists in the Prophylaxis and Treatnnnt
of Opiate Dopandenco".

Goodlluck.

Sinceroly yours,
ﬂax Fink, H.D.
Professor of Psychiatry

HF:ig

�</text>
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                    <text>~“K‘

“-‘mw‘vﬂrw-‘m'"' mm run: n“

"Km 7

‘

»-

'_—zvs.uv§"""xJorv-«mtl‘H-m-rq rm. haw-v! 7‘

«awn

-

1:.er

wry-w

x:-— v—lwa-rh

«no-.W‘ -‘ur',—).In ”p"...

,

\

,_, Ht... “Hrs," w”,

_

.

.

1...

__,.,‘V

.Y,

‘_

March 33, 1972

Julian It. Laoky,
ﬁational Institute of'obntal Boalth
PEAK}.

ﬂockville,

234m land

Eef: mom

M23158~01

Dear Jack,

While the propocal, "Treatment of'Schiaophrenia by
important and interesting goals, the methods are

EU?" has

Regressive
inadequate to

it

tile?

wish. to encourage such
tho invoctigatom to discuss

task. Shoula tho Comrlttoo

for
a program,
'tao loouoo with others: tho lntorrolationo of’modiflcations of‘tﬁe
EC? process to thorapoutlc outcome, and the ioauos in quantifloatlon
of the EEG. In addition, since the twin leouoo in rogrosoivo 3326‘? from
a publéo health point of'olow are the long torn offocto of‘multlple
ooizuroe, coon as an assault on the oontral nervous syctong particularly
on matures of brain function and on ouch capacities as concorztmt’lon,
momory, and thought processes, the evaluation of‘nourological doflcéts
and paychologicol tosto fbouoaod ow what to usually called 'organiolty’
must be conoldored.
would be adviecdalo

The investigators have done an
of'rcgrocoioe EC? in schizophrenic patients.

interesting clinical study
There to a mood for such

a ro~ovaluatlon of’rogroaaivo ﬁll; for thin modification has a chequered
rarely useful. Recent otudloa of’multlple
history. Oldor studies found
Elf; undor omygonatlon control, have indicatod that multiple ECT ans

it

dofloito, or EEG
soft, producing no moro momory loss, neurological ECT
only occasionally
changes than single ECT. Unfortunately, multiple
produces bettor results than single EST in doproeood patients. The data
for schizophrenic patients is unclear, holevor; and thorn now are some
roports of'bottar results with multiple ECT. Those data require vorifloation, and in this framowork, the proposal by Ewnar warrants some

aselstanoo.1h its prooont form, it is inodbquate to the tasks outlined
by the investigators, and suggested by my view of the public health ioauoa.
5%:

favorable foaturos of the proposal:

1) the population is adequate, and the setting to probably a good one for
such studies. (1h our investigations of ECT at Gracia Square and Hillside,
was in those small hospitals that tho staff’wore favorably diaposod tp

it

Elf; allowing tho inventigationa to proceed.)
2)

Tﬁo

investigatora

have an

interact and

coma

experience in regressive

ECT.

�.-&lt;

. .w-r—

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”g:-

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W\Jr‘v4r-'wv-n.wl Jaw.

EXNERO'IIOOOOOUOIOOOOOIOIOOOOOOI. EICOIOOIOOOOOODO

3) The PI

..

.

.n,

.

‘n'mgrﬂwrr

:IWBst"-v~l*’!‘-vm

March 23’ 1972

sahibits statistical and design sophistication, and his

rocord as psychometrist

../.,._~

~....-_».-r.~n.

is

good.

"7”,

The

negative features of the proposal:

1) The design is EDT vs. drug treatment. Ihie
the design to be followed,
issue, but were

it

is not the

most important

there are specific problems.

While the evaluation methods may be adequate indices of
2)
change in personality and behavior, the issue in gegressive ECT is the
impact on interpersonal behavior, neurological deficits, thought
processes, memory, and concentration. In their first study, they
emphasise a persistence of’some of the thought disorder—- but is
and how is
changed ? The clinical aspects seem inadsquately
it different
covered, and the emphasis on a psychiatric interview no less than 30
minutes and no more than 45 minutes is mechanistic and less than helpful.

it

,

ihe EEG evaluation is at thewwrong time for any important
issue. Perhaps the EEG should be evaluated soriatim (weekly) to assess
the rate and degree of change in brain function. But most critical
is the likelihood that the patients will all receive drugs after the
treatment course. The druggcontrols of‘neeeseity; the EC? patients
most probably. Since no statement is Mada about the specific drugs,
dosages, and relation of.EEG measures to drug intake, I have to assume
the investigators are not acutely aware of the impact of drugs on the
536. To unravel EEG effects of BCT from drugs without attention to
the controls necessary, is exceedingly dijyicult.
Zhe same problem in the evaluation and followvup will
occur for other indicss»~ what is the impact of'drugs given after
regressive EC? on the EC? process, and on the comparison of ECT and
drugs ? (For this reason, I would favor regressive ECT vs single ECT).

3)
Patient selection is an issue. The statement of'proceee
schizophrenia is inadequate. The tests described are too non~specific
to help others define the population. It were better for the investigators
to specify which criteria of'process schizophrenia they use (3.9. Fish,
ﬂuylor, others ?). Psychological tests are supplementary~~ they cannot
be used as the diagnostic criteria.

criteria

While

I

am

not ordinarity prone to question selection

ethical grounds, in this instance, the authors should be
asked to make clear some of their minimum criteria of'prior treatmonts
and failure, recent treatmont and failure, etc. before regressive ECT.
Should not all patients have had a course of 'regular' ECT and failed ?
4)
Psychological tests are given heavy emphasis, but the
theoretic base from which these tests more selected is not indicated.
Why the MMPI and the SPEC ? Neither is sufficiently specific in its
interpretation to be very helpful.
on

.

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7..

�M.

,yv.—..-r-.m.~-«.:.

w-vv—

"1“sz -qumwa.

‘f‘~w-"'~'

,—)-wl*'..rxw‘uﬂ-v‘r't‘m‘mw'fran

raw-m

EXNEROIOOOOIOOOOUDI0.00.00.03.00 3

wuvvmuw-mgw..~-mw '3.“ “y“ we

.-4"p~)'I-‘l

.47” 'WF‘J"‘V§‘I’\“‘.w,—,‘-.;.~.-.7r nah”.

OIOOOOOOOOODOCIIOOOOWI!

.»

—.- .

~

emu--

PM

....~

23’ 1972

There are many problems with the EEG measures, but since
I)
the study could be done without EEG measures, I will not go into full
detail of’theinadequacies. It is not clear why the investigators are
measuring EEG effects, for the only specific suggestion comes from the
description of lack of’abnormality before and after treatment, as

evaluated by the neurologists on visual inspection. Ihe issues
that could be investigated are the differences in EEG effects of
regressive ECT vs other Elﬂk the rate at which the induced changes
disappear; the relation of change to improvement, to memory ef?ects,
or to other neurological indicee.

They suggest quantification of'the EEG; suggesting
recording and analysis for short epochs. The equipment they
request, representing a large part of'the budget, is adequate only for
the analog to digital convereion, and some simple steps of'data reduction.
But EEG data ie voluminous, even when reduced, and the interrelations
among many channels a horrendous task. (Indeed, very few investigators
have challenged more than one or 2 channel data, and if'more, only for
1 0r 2 minute epoche).
3 channel

To

is

Their interest in sleep

EEG

is unjustified in the protocol.

eben suggest cloep EEG recording (3 hours), for 8 channels (1),
so voluminous a tack, tiat I suspect they do not mean this. gheir

suggestion about.doing visual analysis of the sleep records is
interesting, but thie too it a big tack, and will not in their
few cases, answer any of the auctions. She came problem of drug
control must be considered here.
#-

10

d

J!

.Ez.reureading this proposal, I believe the investigator
brings to the questions, posed by his clinical colleagues, and experience
as a clinical psychologist and psychometrician. fhese aspects seem well
handled. For 'eeientific' reasons and interests, they are suggesting
EEG analyses, sleep recording, and some follow~up studies. In these
aspects, they seem to lack experience, but also sufficient judgment to
visualize the taske and to obtain advice. Perhaps, were they encouraged
to visit and'worh ith one of the university based centers studying
ECT and one focussed on quantification of the EEG, these issues might
become clearer to them. were they then still interested in the studies
suggested here, a better proposal might (?) be forthcoming.

Alternatively, the design could be reduced to a clinical
replication of their pilot study, with some better statement of'the
population, assessment of’neurologioal effects, control of EC? parameters
and drugs, etc.—- and a contribution made to the EC? literature. In the
latter case, the budget could be subjected to reworking, deleting
sleep and statistical consultants ($3800), equipment ($20,500), and
EEG chart paper ($600); with additions for neurological evaluation.
helpful. Iou already know the
I trust those comments are
these
laboratories
in
interested
issues, and I am confident
principal
that any would be interested in this study.
’ISincerely yours,
Mam

Fink, M.D.

.

u--- .

.7

.,.r

,.

.

_.

�</text>
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                    <text>February 22, 1972
Norman

Pitts,

M.D.

Pfizer Pharmaceuticals
Groton, Connecticut
Dear Norman,

time ago, Garden and Cole asked us to

Some

assist

them

in the analysis of their date of a chronic high and low dose thiothixene
study. They supplied the tapes, we did the analyses. There were some
problems in the data collection, related chiefly to the copperation
of the patients and our inability to train the staff adequately. Hevcrtheleaa,
the analyses do demonstrate consistent EEG effects, similar for the high
dose thiothixene as
summary

I

we

am

found some time ago.

taking the Opportunity to send you a copy of the

report, for your information.
My best regards.

Sincerely yours,
Fink, M;D.
Professor of Psychiatry

Max

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                    <text>February 22, 1972
Dr. E. Garden

Boston State Hospital
Boston, Maaaachusetts
Dear Dr. Gardos,

Enclosed is thc summary report 0! the EEG data analyses
of the high and low dose thlothixcnc studies completed recently. while there

technical difficulties, there was sufficient material to elicit
drug~EEG effects in the lang~tcrm treatment condition. Thu ahort~tcrm
cffccta were less clear, probably as a result of the small sample.
The decrease in mean frequency and in mean frequency
is consistent
variability measures with chronic thiothixcne administration
the
and
with
of
thiothlxcne,
thc
effects
of
ctudica
with our earlier
Pharmacol.
CAnn.
Rev.
earlier
publications
classification proposed in our

were some

9:2blv258, 1969).

h

I trust these data are
information, please call.
Hy

artful.

Should you wish any

further

best regards.
Sincerely yours,
Max

Fink, M.D.

Profcsaor of Psychiatry

cc:

J. 0.

Cole

�</text>
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                    <text>,

WWW”.

.-_‘-.,.___v.-.

.mm

.mm,..,-_,..

.,.,,,_WI

,.

February 22, 1972
Samuel C. Kain, M.D.

Director, Alcohol

&amp;

Drug Dependence Service

Veterans Administration
Washington, D.C. 20420
Dear Sam,

.m

pawl-"Wu”...‘mu,’

I look forward to participating in the 17th annual V.A.
Conference in St. Louis next month. At the and of the week, I will have the
time to write a summary of my presentation on tho panel, and should send
it to you next nook, well in time for the session.
A.nhort c.v. is enclosed.
For the teaching session, I will prepare a summary of our
present treatmont approaches, onphacizing the similarities and the
differenceosin using mnthadono and lnvoncthadyl, and cyclazocino and n31—
crane; and the relation of thosn drug rcgimona to rohabilitation, caaawork,
re»education, counselling, and psychopherapy.

It was kind of you to consider my serving on the steering
committee for the collnborative studios in drug abuse, particularly for
acetylmcthadol. I would be pleased to contribute whatever I can. and have
that my experience may be of assistance. (My paper on l~alpha~acotylmethado1
will appear soon in the J.A.M.A.~— they changed the name of the drug to
the

new

generic

'official' titlo of

My

LEVUNETHADIL.)

best regards.
Sincerely yours,
Max

Fink, 3.9.

Professor of Psychiatry

�</text>
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                    <text>February 22, 1972

M133

Roberta London

Monoging Editor
Contemporary Drug Problems
515 Oxford Street
Heatbury, ﬂew York 11590
Dear H139 London:

v'-

made, the biography submitted, and the
I nave added the latest data to the text, and the
title shortened.
N133 and the White ﬁance
report should be most timely, for the USPHSon- the
antagonists, which
SAODAP are both preparing larger programs
should be announced shortly.
The

own—mop."

“h...

.w

awn..-”

—

v

~—~w-w

corrections are

additional chores, should you docide to prepare a cannabis issue, our studies of the acute and chronic
effects, both in New York and in Athens, are most interesting.
While I am not looking for

I look torwcrd to seeing your

anwwuuy—mv—

first issue.

Good

luck!

Sincerely yours,

,

A

—».

an: Fink, M.D.
Protector of Psychiatry

-~v~mr——wmm.._

Ming
Enc.

.
W.—

A

.mmm

»

"'

mm.

-

w”-

'w-pm

-

�Dr. Max Fink is Professor of Psychiatry and Director of the
Division of Biological Paychiatry of the New York Medical College
in New York City. Since 1966, on has extensively studied the neuro—
physiologic and clinical effecte of narcotic substitutea and antagonieta in opiate dependence. and the effects of chronic cannabis use,
both in the United States and overseas.
He is a graduate of the Rev York University College of Mad~
icine (1945); is certified in neurology (1952) and paychiatry (1954)

the American Boards of Psychiatry and Neurology; and in paycheanalyaia (1953) by the William Alanaon White Institute (New York).
In a research career begun in 1954. he has been Director of Raaearch
at Hillside Hospital (New York) (195A-l962), and Director of the
Missouri Institute of Psychiatry, and Raeearch Professor at Washington University (St. Louis) (1962-1966).
by

Hie principal studies are in the neurOphysiologic (electro—
encephalographic) and clinical effects of psychoactive drugs and
coneeileie therapy. Applying computer methods to these analyaea.
he has provided theoretic models of the relation of EEG changes and
behavior in man, and of the node of action of convulsive therapy.
He

has

just edited a special issue of

Seminanb

in Pbychiazay devoted

to convulsive therapy, and will chair an international symposium on
this subject in collaboration with the Rational Institute of Mental

Healtu in 1972.

Institute of Mental
Administration, the Columbia Broadcasting
Syetem, and numerous industrial concerns. He is the Executive Di—
rector of the International Association for Psychiatric Research,
Inc. He is married, father of three, and is a resident of Great Neck.
He

Health, the
Long

has been a consultant to the National

Island.

Food and ﬂrug

�</text>
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  <item itemId="5183" public="1" featured="0">
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                    <text>February 22, 1972
Dear Dr. Plstcow,

It is quite

I have read the section

good, and

my

on

few comments are

antidepressants carefully.

listed in the margins.

I would suggest that the sections related to the presumed
effectiveness of the MAUI be reviewed, for the available data is chiefly
uncontrolled testimonials. The list of dangers is well documented, however,
and the contrast sufficiently great for us to have eschewed the use of these
drugs in our treatment programs. Indeed, the risks are as great as with the
amphetamines, and perhaps the same cautionary tones should be encouraged.

Recent evaluations of convulsive therapy, particularly
with the modification of unilateral ECT, with succinylcholine and
Brevitsl, show this technique to be 80~9OZ effective (and safe) in severe
depressive states. Perhaps the Council should review the whole range of
therapies listed under 'antidepresssnts', and introduce a section on ECT.
This treatment is surely more effective and safer than the amphetamines
or MAUI. For a recent comprehensive review, see the February issue of
'Saﬁfﬁafg {M organtatﬁy; published by Grune &amp; Strstton.

these notes

may

Finally,

may

give in the

I ask that

list

you acknowledge the

of acknowledgements

? Many

little

thanks.

help

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>n‘w‘

Va.

r-

-

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4v

m

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--

.

~

W “fl-WW"

1-:

v.

,

rdm'wv'nvv"mwl'melwvva—H."IMF—VJ «.wi van

:-

Fabruary 22, 1972

Binaa, Ph.D.
Director of Biological Research
Hoffmann—La Roche, Inc.
Nutley, ﬂew Jersey 07110
Mr. L. R.

Dear Len:

I hava read the data ahaata on Lorfan and RD 6-6711 with
interest. ﬁocuaaing on thair possible uaa in opiate dapandanca.
The data on Ro 4~67ll ahows this to be similar to cyclazocine in structure, with similar side—effects on low oral dosage
(0.5 mg) - sleepy, uncomfortable thoughts, “drunk",bhtt with
vomiting also. Thasa effects reflect a nigh dagraa of agoniatic
effects, canaidarably reducing our intaraat.
data on Lorfan is more promising. It is a well defined
antagonist, and a program dcaignad to extand its duration of action
may be useful. It may be important, howavar, to clarify the commant
in the packaga insert, regarding enhanced respiratory dapraasion
with repeated doaaa. If varifiad, this will be a deterrant to further davolopaant.
The

Thanka

for the opportunity to raviaw these data.
Sincerely yours,
Fink, ﬁ.D.
Professor of Psychiatry
Max

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                    <text>February 11, 1972

Dr. Robert Petersen

Division of Narcotic Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Bob:

Enclosed are the two revised budgets, for the Jamaica

and Greek study prOgrams.

Separately we will send the detailed progress report and
protocol for the Greek study, probably within the next 10-15 days.
For the Jamaica study, we are unable to relate our proposal
to the prior study without your help. With it, we will accommodate
the social aspects to the data of the prior study.
Many

thanks for yourttime.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming
Bic.

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                    <text>February 8, 1972

Prof.

Hebrew

Israel

R. Mechoulam

University of Jerusalem

Dear Prof. Mechoulam,

&lt;7

:-

Mammy-”WV

I have just returned from examining some of the chronic
hashish users in the laboratory of Prof. Miras in Athens. We observed
4 men as they smoked various doses of hashish, U.S. grown marijuana,
THC impregnated placebo marijuana, and placebo marijuana. Our data
is confusing, for the men exhibited 'tolerance' to hashish, but not
to marijuana; they showed behavioral changes to marijuana which seemed
distinguishable from their responses to hashish; and they showed
no reaponse to 75 mg THC.
One

&lt;v:

is the different

of the

mix of

possibilities underlying these
constituents in the

mixed observations

two samples. Before

leaving

Athens, Prof. Miras provided us with another sample of hashish which
has a low concentration of THC, and the men reported this sample to be

'without

effect'.

are replicating these observations in another sample;
THC~A~9 and ~8. I have some
samples of the two types of hashish, and the U.S. marijuana, and I am
writing to ask if you would be willing to assay these for us. There
is some question in our minds as to the actual concentration of the
presumed active substances. May I send 4-6 samples to you ?
and

We

will undertake additional trials with

Many

thanks.

O

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
“swap-7m

vvm-J

rummrvrr‘r'

~
"“7

=

-.

W‘V'm'li‘

mam.

“Mvm‘cvir

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«war—Wm :u,

—..

v.—-‘—vm-um‘,pv_..m -:‘n‘.w m

.

Hmwrwm"~me w-mms—v-W

February 8, 1972
Max

Gordon, Ph.D.

Bristol Laboratories
Syracuse,

New

York

Dear Max,

a follow-up on the inquiry on Clumacran, I asked
the
to review the notas in their files, and I received the
enclosed extensive print~out. This may be 01 interest.
As

ﬂIMH-PRB

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

w—uvv—mn

»

v

m

�</text>
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.W—vrx

~«

«

"wvvnw-s$g‘n

“F...“-

‘--n.—.-.

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,7

Itwm—Vwrrvtmw

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7,”:

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WV.

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yr:

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February 8, 1972
David Davis
PRB—NIMH

Rockville, Maryland
Dear Mr. David,
Thank you for the print—out of the ECDEU summaries on
clomacran. These were indeed very helpful in my decision not to
undertake an EEG study of this dnug at this time.

There are two other searches which are of immediate
preparing a report of the EEG profile studies of
and
doxepin,
clinical evaluations of the compound in depressive
and
in
anxiety states, would be of interest as background for
states,

interest. I

am

the evaluation of this profile.
(Ortho) and

am contemplating EEG studies of ORF 8063
(Pharma Research Canada). Are there any
of these drugs underway in the ECDEU system ?

Secondly, I

PR—F~36—CL

clinical studies

Many

thanks, again, for the data on clomacran.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ay’

,

mm...“

4

:zowang-ya

inf-A,

‘—

�</text>
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We.

,~

w ” at“ m

r.

,

V

V

.

.

V
,

‘

y

,

vane—ow 3'53!“va ~_-.mwrs+ ~ A.»

V

,

,

7

-wwwwwmwiwj

i
i

February 8, 1972
Ms. Judith Kiolbassa
Copy Editing Supervisor

AMA

Chicago,

Illinois

Dear Miss Kiolbassa,

Enclosed is the typescript copy of article 0658 for
the Archives general Psychiatry, and my notes on the text. The
handwritten notes are sufficiently clear, and refer to the text
pages. Please add the additional reference.
Thank you

for your assistance.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

.

-

,

"""-“““ W “F ““'“""' V -

�</text>
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                    <text>.

February 8, 1972

Paul H. Blachly
Professor of Psychiatry
University of Oregon Medical School

Mr.

3181 S.W. Sam Jackson Park Road
Oregon 97201

Portland,

Dear Paul:
Your letter regarding Congressman Pepper's bill is interestI do not know the bill in question, and can only comment on
your questions.

ing.

In general, in our study of the narcotic antagonists, I have

found the FDA verbally c00perative. Their dependence on rigorous
and extensive animal toxicology data has prevented human trials of
M5050 for 2 years, since we have been unable to find $30,000 to pro—
vide this data. The same attitudes have caused delays in studies
of BC~2605, and added immeasurable costs to studies of naloxone.

to your suggestions, I believe these are useful and may
- who discussed some
proposed changes in his section of the FDA at the recent ACNP meetings.
As

be in the process of adaption by Elmer Gardner

I would not encourage another committee. The present NINEcommittee reviewing protocols for drugs is sufficiently restrictive and limiting in its views (E;E° of cannabis) to provide a lifetime of delays and excuses to stifle research another could do

FDA

little

—

good.

I

not encouraged to attempt redress by the Congressional
or committee routes both are fora for selfish ”politics" interests
and not effective roads to research. The latter can only come from
the scientists assuming the burdens of research and challenging the
variOus agencies' on a case by case basis. Perhaps it is in the
education of our colleagues (345., the limitation of unsophisticated
dependence on animal trials) that our hopes and opportunities lie.
am

—

Sincerely yours,
Max

MF:ig

Fink,

MA).

Professor of Psychiatry

�</text>
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u.“ WY s—vmw-m

February 8, 1972

Miss Risa Dickstain
Vcra Instituts of Justice
30 East 39th

New

York,

Strsot

Now

York

Dear Risa:

I road of your prcsontation to a lcgistativo commission
raaliasd that tho heroin program has been well
formulatsd. If a copy of the proposal is frooly available, my

on Friday. and

associatcl

and

Good

I

would

luck. and

like to road

many

it.

thanks.
Sincarely yours,
Max

Fink, H.D.

Professor of Psychiatry
MF:ig

�</text>
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                    <text>-Ww

February 8, 1972

Dr. Arthur W. Tacroitor,
Merck Sharp £- Donna

3.0.

Division of Harck &amp; Colpany, Inc;
Heat Point, Pcnnnylvania 19686
Dear Dr.

Tacroitor:

for making additional ouppliao of tralpha-acetylmethadol available for our studies. I an ancloaing the appropriate
3ND 222C form and a xerox of the schedule I permit PF0024555.
Thank you

I trust our ongoing studies will continue to support the
usefullssa of this compound.
Sincerely yours,
ﬂax Fink, M.D.
Professor of Psychiatry

ﬁF:ig
Enc.

.

�</text>
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                    <text>February 8, 1972

Dr. Turan M. 1:11

Professor a Asaociate Chairman
Chief, Section of Clinical Neurophysiology
&amp;

Psychopharmacology

University of Missouri
5400 Arsenal Street

St. Louie, Miaaouri

—

Columbia

63139

Dear Turan:

Congratulations. on your energy and enthusiasm to edit a
and drugs. It would be a pleasure to participate, and
I will try to provide the two articlea you requested.

book on

CNS

our

new

EEG

"EEG Profiles to Identify New Psychoactive Drugs and Measure
Bioavailability" by Fink and Shapiro will privide a aunnary of

classification scheme, and our recent 4 years of experience
drugs and conpariaona of drugs of different fornulationa.

will

I will be glad to work with Volavka to prepare a summary
Effects of Druga of Dependence and Abuse". describing the
similarities and differences among alcohol, opiates, amphetamines
and LSD, etc.

on

“CNS

In your

list

of proposed models. I aieaed a presentation

by Don, and note the tapic XII ~ Statistical Techniques. while I
aeaune you will ask Mucciardi, perhaps you would reconsider. Muc~
ciardi'e experience in limited and his recent report to you primitive.
Don and his aaaociate Marvin Glaaaer have examined acne of our data
by many etatiaticel techniques. Our data is extensive and an invi~
tation will provide an incentive for then to present their experience.

�away—w

mnw~

u

-

Dr. Turan

I

M.

Finally,

do not know

Fun,

fun.

Itil
who

.

February 8, 1972

aro Caillo, Danbcrg, Horowitz, and Robinson?

thoir work. Should I?

tho 3 F's, I havo addad a fourth - Flying; nnd Family,
Financial arc vary unaful guidelines. The chapter: will be
To

My

later this

but to Ellan,
month.

and

I look forward to using your family
Sincerely yours,
ﬂax Fink. M.D.

Profasaor of Psychiatry

�</text>
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                    <text>,,

...

.
w...“

‘qu.an

1-. ‘

.vmmmmtwmmawwanmw—uw

February 7, 1972

Dr. Leo E.

Holliater

Hedical Investigator
Veterans Administration Hospital
3801 Junipero Serra Blvd.
Palo Alto, California 94304

-/v-A

ur—wv-W—w—u—w‘

Dear Lao:

studies of cannabis are proceeding in chronic and
acute trials in volunteers in New York and in studies of long term
hashish users in Greece.
Our

The ﬂew York

studies are focused

on the behavioral. memory,

and SEC effects of different doses of sacked marijuana, both in
single dose studies and 21-day chronic studies. The data define
the central EEG effects, bear direct dose relationships, and show
some evidence of tolerance development. These data could be pre—
sented as "EEG and Behavioral Effects of Marijuana", by Pink, M.,
Volavka, J. and Dornbush, R.
we have examined 35
we are now comparing

In Greece

subjects

who have used neon-

the effects of seeking hash~
years,
THC~8-9,
and ganja (Jamaica) on beish (Greek), marijuana. (U.8.),
havior, EEG, heart rate, and performance tasks. These data could
be presented by Dre. C. Stefanie or C. Miras - "Long Term Effects
of Hashish Use" by C. Stefania, C. iiiraa, R. Dorcbuah, J. Volsvka,

ish for

and

M.

+25

Fink.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>February 7, 1972

Dr. Stanley Muhler
Office of Aviation Medicine
AHrlOO

Federal Aviation Administration

mmmgm,mm
Dear Dr. Muhler:

City, invited the participation of our laboratory in a conference on cannabis in Oklahoma
in June. When the invitation was discussed, we realized that a
flight simulation task would be a most sensitive index of central
nervous system effects. Indeed, the sensitivity of the driving
sienlation has been demonstrated, and the additional planes of
Dr. James Lewis, FAA. Oklahoma

'Im—v

-

reference of the flight simulator should exaggerate the sensitivity

greatly.

Are

,wvw.v.w‘m

consideration?

studies of cannabis on this task in progress, or under
If not. would such studies be of interest?

w,

are involved in a variety of studies of cannabis in
volunteers in the United States, and in chronic hashish users in
Greece and Jeeaeca, West Indies. My personal interest is based on
my recent licensing as a pilot, BEL.
we

Thank you

for your reply.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

w-

W's-v"

“rm-ewe-

'

m’oW‘W

www-

wwwx-

MF:ig

�</text>
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                    <text>February 7, 1972
Dr. Avram Goldstein
Department of Pharmacology

Stanford University Medical Center
Stanlord, California 94305

Dear Avram:

reports to the Methadone Conference were progress
reports, as participants in a symposium. The basic data is in
press, the cyclazocine in Comprehensive Psychiatry (1971), naloxone
in JAMA (1971), and the iralpha—acetylmethadol in JAMA (in press,
Our

1972).

though you

It

does not appear

may

wish to

LVT‘

useful to reprocaat these reports, al-

cite these sources.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ig

Resnick, R., Fink, M., and Freedman, A. Cyclazocine Therapy of
Opiate Dependence - A Progress Report. Comphehenb. Psychiat. 12:
491-5023 1971.
Zaks, A., Jones, T., Freedman, A. and Fink, M. Naloxone Treatment
of Opiate Dependence. JAMA, 215: 2108-2110, 1971.
Zaks, A., Fink, M., and Freedman, A. [ralpha-acetylmethadol in
Maintenance Treatment of Opiate Dependence. JAMA (in press).

�</text>
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                    <text>ruv-v—u

mow—w‘n.mm‘la‘”"rﬁv’ni~xﬁm“r4-'

,

_

,

,

.

.

February 7, 1972

ﬁr. Stanley Einstein, Ph.D.
Associate Director
Division of Drug Abuse
Associate Professor
Dopartannt of Provantivo Madlcino

&amp;

Community Hoalth

Harriaon S. Martiand Hospital
85 Bergen

Nauark,
E

Stroct

Jorooy 07107

How

Dear Stan:

It

1- an intoroating program that you are planning in
and of May. I would liko to attend, but can do so

Israel aadthe

only

if

funda

for travel are

nada

available.

Sincerely yours,
Fink. H.D.
Proteaaor of Psychiatry

Max
i

'1‘

y".

w

”77'1”"

'wv—x

mu»

,‘m,

Y—vvrww.—v—wl’—-

a...”

v.

um-nwav-n—w

.

HF:13

1

....

---

Wyn“

�</text>
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                    <text>February 7, 1972

Dr. Frank Veress

Director
ICD

Mental Health Clinic

New

York,

340 East 24th

New

Street

York

Dear Frank:
The program of seminars you outline is so extensive that
be necessary to discuss the best way to satisfy your request.
special subject is the use of long term phenothiazines', for
should this be an important aspect of your treatment program, there
are some new compounds which require evaluation - an injectible drug
for 3—4 weeks, and a 7-day oral drug.

it may
Our

request.

It

may

be useful for you to

(369—7900).

visit

my

labs and discuss your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ig

�</text>
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                    <text>E
February 7, 1972

Dr. Juan de Dios Pozo-Olano
21 Webber Avenue
Bedford, Massachusetts 01730
Dear Dr. Pozo~01anoz

Neither of the articles you requested are available.
Psychiatric Research Foundation of Missouri, Publication No. 65—
10 was a preliminary report of our EEG
sleep classification studies,
and was recently much elaborated and published in EEG Clinica£ Meadophyéia£.,,27= 76—83, 1969.
—

Psychiatric Research Foundation of Missouri, Publication

No. 66—1, a manual

and no copies are

prepared by Shapiro and myself, is out of print

available.

I have not yet seen your report on computer studies of
brain waves, but would be most interested in sharing a copy with
my associates.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:ig

�</text>
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                    <text>February 5, 1972
Paul Janssen, M.D.
Janssen Pharmaceutics
Beerse, Belgium
Dear Paul,

I have

first

You gave me so much

sorted

my

thoughts

to think about during

this week-end.

my

visit, that

I am most delighted that such longer acting narcotic antagonas R 15497 provide a basis for further development. Should the
minimal toxicology data, and supplies be available, we will file a
research IND with the FDA, and undertake the clinical testing to assay
the dUration and extent of narcotic antagonism (measured as the response
to intravenous heroin, 25 mg/2 cc saline/2 minutes) in post-withdrawn
opiate dependent subjects. We would also evaluate any agonistic features.

ists

Should

it

prove to be an active antagonist with a duration

greater than the available

the long-term clinical

compounds, we

trials.

will support

and undertake

I called Dr. Allan Green (U.S. Special Action Odfice, The
White House) and Dr. Jean Paul Smith (National Institute of Mental health)
Center for Studies of Drug Abuse) to tell them that I had reviewed some
of your compounds of interest; that these had been tested by the
University of Michigan and the data were in the appropriate archives;
showing these compounds to be similar to others already under investigation;
and that prior to further study, they required, as with M—SOSO, additional
formulations of supplies and animal toxicology studies to satisfy the FDA.
Dr. Robert Rees also called and I repeated these observations.

variety and special characteristics of your many new
fascinating. 0n the return flight, I read the many clinical
reports carefully, and am impressed that penfluridol should be an
The

compounds were

important improvement over our experiences with fluphenazine enanthate
and decanoate. I would like to evaluate penfluridol in our V.A. unit.
I have given the data to my associate, Dr. Alexander Don, and we will
write to Dr. Stevens at MsNeil, to ask him to visit with us on his next
trip to New York.

�.
L“

man‘s

“ac-'9.

Paul Janssenll.OOOIOOOIOOIIOOOOIOI. 2 IClo...-OIOOIIOOIIIIOFebruary 5, 1972
The usefulness of tetramisole as an antihelminthic is
dramatic, and the possibilities in oncology most exciting. It is the
alleged antidepressant activity, however, that interests me. We are
assaying one compound, ORE 8063, from Ortho Research, in our EEG
screen, but our methods may be more appropriate to examine the
possible central activity of tetramisole. I will call Dr. Bill
Pollack as you suggested.

With regard to haloperidol in addiction, I have reviewed the
available to me, and the suggestion by Lal is interesting,
though poorly substantiated.. I have intererted an experienced member

summaries

of my staff, Richard Resnick, to examine the data and he will design
a study, which will run in parallel with the ongoing trials of narcotic

antagonists.

I enjoyed discussing and reading the descriptions of the
compounds
other
in your catalog. You are to be congratulated
many
and
the
Special characterittics of your products. A
on
variety
30-day narcotic antagonist would complement your list most dramatic-

ally!

visit
visit

Your hospitality was exemplary; your family charming; and the
most memorable. Please give Dora my best, and trust that your
'down under' will be exciting and interesting.
My

thanks for your many, many kindnesses.

Sincerely yours,

“Whittx’GVG—"m'

,_

rw

m"‘-v.

waw-vwmcm-mmwui-Wmam

7r—’

wai'

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>February 4, 1972
Gary Boyer

&gt;m‘o;r.w~

wqwr.w..—WV....&lt;

.,,.,m-W

Center for Studies of Narcotics
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland
Dear Mr. Boyer,

“A”,

W.-

.,_,,.,.,.._

.—-.,

gmrﬂ—mw

As Dr. Durnbush explained, we have become most interested
in dissecting the different responses we have observed in chronic
hashish users in Greece in smoking hashish, U.S. marijuana, and THC.

availability of concentrated

The

an opportunity to

men.

~

dissect

some

THC-A-8,9, CBD, and

CBN

of the responses of these

may

provide

'tolerant'

v...»

weuvv—m-K'ﬂ'”

.nmw

Enclosed is the official BNDD order form, 222C for the
substances requested, for use in studies under contract HSM 42—70-98,

in Greece.

n."

it

We

will be visiting

expedites delivery,
Many

but,"

we

Dr. Petersen on Thursday, and
with you that morning.
meet
can

thanks.
Sincerely yours,

-

ru

-,»~yu—.~uw~

.

(Jenna-Ar»;

1'

r
~

Max

Fink, 24.0.

if

�</text>
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                    <text>r‘—¢""

:
rwr

January 25, 1972
Eugene Vogin, Ph.B.
FDRL

Haspeth,

New

York

Dear Gene,

I have read the final renort on the delayed release
preparation for narcotic antagonists, and feel that much progress has
been made. Surely, the effort should not be discontinued.
With this in mind, I have asked Dr. Freedman to file
a copy with the ﬂew York State Narcotic Addiction Control Commission,
and to enquire 6f the NINE and SAODAP whether they have an interest
in continuing this project. Meanwhile, I would suggest that you
file such requests as you may wish with Dr. Bergner of New York or
other agencies as may be available.
My

important study.

thanks for your cooperation and

interest in this

Sincerely yours,
?'1ax

Fink ,

PA:

0

D

0

Professor of Psychiatry

�</text>
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                    <text>January 24, 1972
Walter Essman, Ph.
Queens College

Flushing,

D.

New York

Dear Walt,

I would be pleased

if

you would consider an evaluation of

the central effects of 01—63, the l~10 polypeptides of ACTH, with a view
to elaborating the observations of DeWied and of Indrocki. We have
assessed the EEG effects in volunteer males, and in our pilot study have
observed systematic changes to 10-12.5 mg intravenous. The changes are
seen withing a half an hour. The effects are more prominent and somewhat
unpleasant in dosages of 15 and 20 mg. These data are insecure, however,
and require verification in a systematic study, which I plan to undertake

this spring.

Should you wish to study this compound, the monitors at
Organon are willing to allow some of the material to leave my laboratory;
and should there be some eXpenses for the chemistry, I amy be able to
obtain some support. I am most interested in your opinion as to whether

the

data justifies the conclusion that the drug may have effects
and thus may justify studies in man during the ECT process.
I had suggested such a study to Dick Abrams, and it was he who reminded me
that your methods are probably much more sophisticated than our human

on

DeWied

extinction,

methods

for such evaluations.
In addition, I

am

I will call

my

enclosing copies of the reports sent
his ddta in your
presentation at the meetings in April.
by Dr. Dunn. I would hope

that

on

you would include

return later this

me

month.

Sincerely yours,
Max

Fink, M.D.

""u

"”1“

A’WUW“

P.S.

Can you

vet

my

application to the Neuroscience Society

7

Thanks.

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                    <text>,.—VV_,.

...

January 24, 1972
Charles

Inturrisi,

Ph.D.

Cornell University Eedical College

New

York City

Dear Dr.

Inturrisi,
Enclosed

is

a sample of

MK—790,

which you requested.

We are not, at present, planning intensive studies of methadone.
Nevertheless, I have sent your letter and reprint to Robert Levine, M.D.
of my staff, for his consideration. Should he or his associates wish
to establish a study, he will contact you. It will be necessary for
a protocol to be written and approved by the appropriate commitees of
this medical school, and I presume of your ownv- but those details can
wait on some common interest.

for the assay of MK~790, then
in
interested
correlating the blood levels of
definitely
thsi compound with the clinical course of our subjects. I wish you

we

would be

Should you develop methods

success, and should you achieve the result, olease call

me.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

cc: Robert Levine, M.D.

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                    <text>-.

-.-‘-.w7.-..,w-—.....u.n. :mwt ,~~

V

«mvmyvml «smwuw-r-mwugmu-z m.
-

-»

"h‘w‘r‘ _

..

ya“

_,

namwv

.

w»

I. in?

ww— --

~

~~«..~n,w.-

0-6! “New“...

._

~...-

u r.

w".

.

w,

w"...

m

mm

“a“:

w‘III-rvvnx-q'lmvv

-—‘.

I”
.

,

vm-rwmwmm.

"hwy..-

,

'1‘ﬂrw¥~"'wnr'"'W:-—

m1

n
r
v

January 24, 1972
G.

F. Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Cary,

The Lord

preserve us from.the enthusiasms of childred

!

Your letter about the M5050 situation was most welcome, but
the situation is murky, confused, disorganized, and typically American—during the War, we described the situation as SNAFU.
To recapituiite: our laboratory became interested
in the antagonists in 1967. We heard of diprenorphine and contacted you,
as well as Lederle. They were uninterested~~ you and we were. We proposed
a study of the animal toxicology, peior to obtaining an IND to assess its
activity in man. We requested funds of the New York State Commission,
but were denied. We tried NIbiB, the Cityoof New York, and private donors-~

and each

felt that

such

trials

were the expense of

industry.

tried Nlhi,

and they were receptive, and.
Meanwhile, the White House
appointed a brash, young man to h.ead its program; and he asked for assistance
from other brash young men, without experience. Nevertheless, when they
called me some weeks ago, I shared the full file with them, for
is
irrelevant to me who provides the support for the animal work. They
called to ask how much material I had, how much would be nodded, etc. I
answered, openly, and offered the material in hand to start, and indicated
that I would write you for additional material as needed.

Last

summer, we

hence the application which you read.

it

last week, Dr. Green told me that he had assumed full
the program; that he had called you; that there were
for
responsibility
the usual bureaucratic complications of the precedence of a U.S. grant to
do the work of industry, and who would get the rights if the material was
successful, etc. I suggested he review the massive contracts between the
military and industry, and that he disregard the trivial amounts necessary
heae. But, he indicated, that I did not understand his many problems, etc.
Then,

MIME has indicated that they will fund the grant
of
first April; and the City of New York has indicated that they
fund
animal trials, if I guarantee that we would have enough
the
will
do
the clinical work thereafter (which I did); and Drs. Green,
material to

about the

Meanwhile,

Jaffe, et al. are

runnung about.

.

.

.

,

�..

v

w

'7- '

~,

-

»

-«

'vnwrr

Jr

u'vhb-J'vvn'rr.

,.

'

n1”:

,

_

x

A

,

wv'ip::—

. .
”7"1'30'.N‘W‘F="|"'Y:'XKW»

.. ,,

.7

,.'mriwlwﬂ‘wmﬁl—(wé-WNWﬂW'thWH‘.

_

‘nr—I‘»

».\

My reaction is similar to what it was last summer—- to take
holidays. I am off to Greece for the week, and hopefully, the various
competing agencies will resolve their problems.

some

Our position is what it was two years ago-- we are prepared
interested in establishing the clinical efficacy, dosage range,
toxicity, utility, and anything else that may be interesting of the antagonists
in opiate dependent subjects. We are now embarked on essays of naloxone

and

pamoate; have been promised l-cyclazocine next month; and

BC

2605

in

Should some agency probide the basis for an IND, we will do
what we can-- and hopefully, R 8 C will make some material available
for our studies at that time. Or, should I husband my present supply,
and let MIME, Green and Jaffe, and New York City obtain their supplies
from you ?

April.

Incidentally, in the usual disorganization of our governement,
will probably get out funds, eben if the toxicity is done at the
military centers in the v.3.

we

I look forward to meeting John Lewis again. There may be

error, however, for I believe the Drug Dependence meetings are
to be held in the late Spring in Ann erbor and not in February-— unless

some

he

is

coming to a committee meeting and

scientists in the field.

that is not

open to the

Keep weal, and do what you must to secure your compound's
study. While I would like to be its monitor, I do not see how I can ask
us are brash, and unSOphisticated, and tend
it, for the forces aboutwherever
and whenever they can.
to assert their powers

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mm

.4.‘

w..-

.
4.,

amyyrcwm-w.au-awm-

'n'

v-um

.

.7...“

”WA

5.-

r,

»,

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�</text>
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WW“

r1.

"WFWW-

mv

"-uvurl

A.

‘.

um—umwr-r

January 24, 1972
Elmer Gardner, K.D.

Division of Neuropharmacology
Food a Drug Administration
Rockville , i'iaryland
Dear Al,

It

pleasure to hear your rational presentation
that your approach will bear happy
fruit, in establishing feelings of cooperation between the investigators,
industry. and the Administration.

before the

was a

and I do hepe

ACNP,

The advances in EEG quantification have been rapid. Much
of the information has not yet appeared in press, although Jon Cole
just published a study classifying fenfluramine as a sedative compound
(Paychophanmaco£ogia 22:369-383, 1971). I am enclosing some preprints
and reports of our recent studies, and trust that these may interest

you and your

associates.

My

best regards.
Sincerely yours,
Fink, M.b.
Professor of Psychiatry
Max

é

o

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.,_

.va-r'ﬁ""m w ‘. I.run».. P . ...,., “a ”“5,-».mv: v, J
_

-

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.-

January 24, 1972
S. Clyde

Strickland,

Herck, Sharp

West

M.D.

Laboratories
Point, Pennsylvania
&amp;

Dohme

Dear Clyde,

It was a pleasure to discuss-the EEG and methadol
research programs, in Las Vegas. As I indicated, our report comparing
methadone and lualpha-acetylmethadol, has been accepted for publication
in the Journal of the American Medical Association, and should appear
within the next two mohthe.
would like to extend our studies, and I am writing
to request additional supplies of l—alpha-acetylmethadol, should
We

still be available from your laboratories. Since it will require
12.5 grams/subject/year for an evaluation, we could use up to
1250 grams/100 subjects; or any portion thereof that would make the

"these

study possible.

Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

P.S. Should you be able to make a supply available, I will submit the
necessary BNDD forms on request.

-

:

~

Au

-

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“M w... ‘EVIIM-

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January 24, 1972
Samuel Kaim, M.D.
1200 N. Vash Street

Arlington,

Va.

22209

Dear Sam,

It was a pleasure to discuss the programs of the V.A.
with you in Las Vegas; and I do look forward to joining you in the
sessions in St. Louis.
There

is

a need

for the

NIMH

and/or the

V.A.

to undertake

a more extensive evaluation of l-alpha—acetylmethadol. I believe the
V.A. can do it, and am taking the opportunity to enclose a copy of our
report, comparing methadone and l-alpha—acetylmethadol. The report has
been accepted by the JANA, and should appear within the next 6 weeks.
have continued our studies since the report was completed,
and the present group of patients continue to fulfill the expectations
established by the patients in the study. I would like to establish such
a study as part of the programs at Stony Brook.
We

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>,___

.,.

,

,.,-,..A.._r.:

.

n-

-

.,

._,a

nvr.._.r~.,..,..v.;.x.—;~,7

r,l....y "new”...

.,.

.

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w. ,1.

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:»"'I:»‘

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wan-7‘ VIN-W“

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.17

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was.

January 24, 1972

unsw—

,me

Nathan 8. Kline, M.D.

Director of Research

Rockland State Hospital
Orangeburg, New York 10962
Dear Nate,
As you know, I have been most
interested in the development
of narcotic antagonists as a treatment ior opiate
dependence. After many
years of effort, the model has been supported by clinical studies, and
the qualities of an ideal antagonist have been defined. The National
Institute of Mental Healhh, the SAODAP of the White House, NACC
the
State of New York, and the City of New York are all interested inof these
programs. They are making research funds available, and their
support
has much to commend

it.

However, the principal agencies that have the facilities to
produce the necessary formulations, the industrial laboratories,
preoccupied by their prior committments, and some effort should bearemade
to bring the needs of this program to the attention of the formulating
chemists. With this in mind, I would ask that you consider approaching
some of your foundation friends, with the idea
a special award be
established for the production of a successful that
formulation with the

following characteristics:

specific narcotic antagonism, similar to naloxone;
duration on single administration of 90 days, with
antagonism to injected heroin, 25 mg/ch/2 minutes;
tolerated by man ('safety'); and,
without agonistic features.

is the most likely starting substance now at hand, but other
candidates may be l-cyclazocine, diprenorphine (M—SOSO),
other
specific antagonists now under study at Bristol, Geigy, or orother
labs.

Naloxone

A single prize of $50,000
or $100,000 for 36 months, well
publicized and supported by the authority of one of the leading
found~
ations may serve this program handsomely.

I hope you agree, and raise the question at the best levels.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychigggy
r//\

.

s..,.,..,..7..,..

, ”r,“

e,

vs, ,7...“

y...

�</text>
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January 17, 1972

Dr. Elna: Gardnar
Division of Nouropharnacology
5600 Fishers Lano
Rockvillo, Maryland 20852

Dear Dr. Gardnat:
Enoloaod 1a our application Cor an Inn for 01-63,
a potential paychoactlva compound which in to be coated in

our

EEG

profila syatau.
Many

thanks.
Sincaroly youra,
Ha: Fink, 1-1.1).
Profoooor of Payohiatry

“£313

inc.

Aw—ngrm: ..WV'17.V

4-1.

—

�</text>
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                    <text>M

E

M

0

R A N D U

M

January 17, 1971

To:

Alfrod Froddnnn,

mm:

mm Pink, 21.1).

SUBchrzz Protocol

Addlttion

~

M.D.

High Dooo

CD3

Itootnont of Alcohol

Tho ottoohod protocol 18 on intorooting expansion of
the ongoing studio. of drug dopcndonoo. Constantin; out recon:
difficultioo with the KING Roooorch Connittoo, would you one:
with Dr. Lovino and porhopo, v0: this protocol by calling Dr.

Lohr?

Thanks.

HFalg
Ehc.

�</text>
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                    <text>wry-m.

a—u—r

~rvr

m

1
a

wwwarnmuw-ru.

'1.
aw.-

January 17, 1972
Maxwell Gordon, Ph.D.

Bristol Laboratories
Syracuse,

York

New

Dear ﬂax,

pleased to have the opportunity to review the
clinical pharmacology data on Clomacran— SKF 14336, for I had heard 05
the compound but had not read these dlta. It is a well studied compound,
and there is sufficient conventional evidence that the drug has antipaychotic activity. One of the questions that should interest you
is the possibility that it may have unique pronerties, but this hypothesis
is questioned by the two comparative studies.
I

was

Considering the extensive clinical studies, the EEG analysis
will
'after the fact'. In our recent work, we have ftcussed
on those compounds with interesting animal profiles and with limited
human data; for an EEC analysis is time consuming, and we have yet to
'prove' that this technique has merit. An analysis at this time would
add little to your body of data that would be helpful to your clinical
or your FDA position.
indeed be

Many

thanks for the opportunity to read this material.

Sinceeely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>,,._,,~_ 7....‘l‘n.._....,..v

V

.

.

,

,

,

w,

.

,

...

t

..‘t

...

.

..

..

...

January 15, 1972
‘—

»:u

n,

-

Jerome Levine, H.D.

Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Rockville, Merylhad

ﬂ-ﬁmv'70‘wﬁ-

....

Dear

Jerry,

have been asked to examine the EEG pragile of
clomacran (SKF 14336), with a View to defining any unique preperties
of the compound. From the availahle data, it appears that the
We

clinical studies are extensive.

would be helpful for me to have an opportunity to
read the summaries of the ECDEU studies of these compounds. Is

It

possible to request such a readwout

it

?

ﬁany thanks.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>H E H

0

R A H D

U M

January 1‘, 1972

TO:

Alfred Freedman

FROM:

Max

SUBJECT:

Study

Fink

at Hontroaa

V.A.

is internataa 1n boginntnx lone paychopharnacology studies. The attached protocol examines the relation
of EEG, blood lavol, and behavior of butaporaziuo in $0h180pht€*
Andy Don

nia.

The protocol has bean accoptad by Dr. Barrio and Dr.
Rackow, and I on writing to obtain the cooyeratioouof tha chan—
1otl at A. H. Robina for tho blood atudiao.

Ara

MF:13

Enc.

thara

any other

atop: nocaooary?

�</text>
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                    <text>Ianuary

Dr.

14,’ 1972

Hilliaa Tabor

A. B. Robina Company
1407 Cummings Drive

Richmond, Virginia 23220

Dear

Bill:

Enclosed are two copies of a protocol to assess tho
level, and behavioral effects of the formulations
of butapcrazine; and a copy of the curriculum vitae of Alexander

EEG,

blood

Don.

will request supplies of both cone
tablet butaporazine, and a small amount of placebo
of either formulation; your willingness to file this protocol
contrate

In the study,

and

we

as a supplement to the concentrate IHD; and the cooParation of
the laboratory ~ to assay the blood ramples for butaperazine

levels.

Dr. Don was

my

student in Hiaaouri. no taturnad to

South Africa to raise a family, and than emigrated to the U.S.
in Nova-bar 1971. He is capable, and interested in the special
problcna of drug availablility. For this reason, I posed the

quastion of this protocol.
The study

will

be reviewed by the appropriate insti—
and should be ready to begin by

tutional authorities shortly,

nid~¥abruary.

to Jaca

Many

thanks for your teaporation and

and Fred.

my

best regards

Sincerely yours,
Fink, M.D.
Professor of laychiatry

Max

Hrzig
Enc.

�</text>
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                    <text>,

ﬁr. Hilton

Feldman

Treasurer
Grune a

January 12, 1972

Stratton

I11 Fifth Avenue
New

York,

New

York 10003

Dear Hr. Felduan:

vriting to request a quotation for 50 and 100 capies
of the February 1972 issue of SeminaAA in Paychiatay, on the topic,
Electka Canvuléive Thenapy, at the author's discount price.
I

am

Separately I have requested

for tho eantribucors.

100

reprints of each srticlc

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

31:1;
cc:v

Hill Rafael: Valdez

�</text>
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                    <text>me
I

I

I

I

I

I

I

I

January 12,

1972

ﬁles Rafaela Valdez
Rnprint

£=£annger

Crane &amp; Stratton
111 Fifth Avenue
Nay York, Haw York 10003
Dear Miss Valdsr:
With regard to tuc February 1972, Seminaab in Paychiatay,
on the topic, Electao Convulblve Therapy, Volume 4. Rumber 1, we
would like to purchase 100 reprints of each article beginning with
page 3.
.—w"nw:u-—-r‘mmmwmw'

There are

8

articles.

tation for this requnac?

is acceptable.

A

Hould you provide a sinala quopurchaae order will follow if the price

Sincerely yours,
Ha: Fink, M.D.

Profassor of Paychiacry

31:13

�</text>
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                    <text>“nu-Av]?

—.—-rvm,~a-.-~mww .

n -.:.r-

.1“

;‘ch-

~

~

music...

January 12, 1972
Y.

Langlois,

M.D.

Pharma—Research Canada, Ltd.
Pointe Claire, P.Q.
Dear Dr. Langlois,

I have been delayed in completing the protocol you requested
by the ongoing wprk, but will complete the program outline shortly. The
data submitted is sufficient for my purposes, and we should plan to
start the pilot phase with doses of 25 mg, and increments at this
dose.

To

compare the compound with fenfluramine

will require the

be able to
availability of this agent in identical capsules. Will you that
we obtain
arrange for.the supply of this standard or is it expected

this

compound

7

Thank you

for your interest.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>January 12, 1972

Drs. Ivor and

once Small

Indianapolis School of ﬁcdicine

1315 West 10th Street
Indianapolis, Indiana
Dear Dru. Joyce and

46202

Iver:

«a..-

,-...,..—_A

.,

-m...._,

an,“

of

I want to thank you for your contribution to the issue
in Pzgchiatdy. I am grateful for your couperation,
pleased to make available 100 reprints of your contri-

8£m£naAA

and

I

am

bution or

my

expense.

If you nave already ordered
change your order with this in mind.

reprints,

you may with

to

I harm your suggestions for title changes for the ECT
seating in April, and as noon as I have an opportunity to review
those with the program connittce, I will answer your letter more
spocifically.
My

boat rcgards.

Sincerely yours,
ﬂax Fink, M.D.

Professor of Paychictry

33:13

�</text>
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                    <text>Janunry 11, 1972

or. Ferris Pitts

1035 Bellview Avenue
St. Louis, Missouri 63117

Dear Peta:

I want to take this opportunity to thank you for your
contribution to the February 1972 issue of SeananA in PaychiaIAg.
I have seen the page proofs and the issue should be out within
four weeks.
a small payment for your participation in this volume,
I have asked the publisher to aako available 100 reprints of this
urticle without cost to you. You may wish to review your reprint
needs with this in nind.
As

ﬁy

bolt regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

ﬂrzig

�</text>
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                    <text>January 11, 1972

Dr. William Gal?

Biometric Laboratory
1145 Nineteenth Street, N.w.

Washington ,

20036

D. C.

Bear 8111:
Enclosed are the data sheets and covering notes for our
study of GP-41299. we assayed this clinical study following the

demonstration of Specific
Tuero

scale data.

is

EEG

activity.

one general purpose

scale used, for our anxiety-

Should there be specific questions regarding the data
shoots, please call the study coordinator, also Sauna Durbin at

212-360~6746

or

Dr. Abrams

Thank yOu

at

212*360—6746.

for your assistance.
Sincerely yours,
Max

Fink, x.D.

Professor of Psychiatry

ﬁrzig
Enc.

�</text>
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                    <text>January 6,'1971

TO Wﬂﬂﬁ

IT ﬁAX COﬁCERﬁ:

Doctors Professor aha: Dornbush Ph.D. and ProfessorﬂewJanYork
Volavka, H.D. are mambera of the Department of Psychiatry,under an
ﬁadical College and are carrying out studios in cahhabis
Grant 18172 and Contract “5% él~70~93 (Studies of Marijuana Users
in Groece).
Under the terms of those grants, Doctors Dornbush and
Volavka are carrying with them marijuana oravidcd by the Rational
not exceeding 500 grams
Institute of ﬁental Realth in an amount
which
an import document has
and 200 grams marijuana ylacebo, for
of
Greece.
been obtained {rem the government
thom sup—
their return, oitner or both may bring with
invcs~
by
our
forms
provided
plies of hashiah or cannabio in other
attached.
tigators in Greece. An import permit for this is
On

This inboratory operates unéor the appropriate regulations
of the United States Bureau of Narcotics and DongcrOus Drugs and the
Sttte of ﬂow York, and copies of these documents are attached.
In the evcnt that any questions arise regarding the truns~
or from
for of those materials from the United States to Greece
undersigned
the
Grooce to tho United States, we urns you to contact
Na~
at 212c369-8‘83 or 516-666—56‘k or Dr. Robert Peterson at the

tional Institute of ﬁontol Heclth (301w443w4663).
In the event that problems aria. in Graces,

we urge you
of
Biological
to contact Professor Constantine Miras, Protcnuor
Costa: Steand
Profossor
Chemistry, Univuroity of Athens (771«155)
(6&amp;3—2025).
Athens
of
fania, Professor of Psychiatry, University

�Thin projact has been brought to the attention of the
American Ambassador to Greoce, Hr. Charles Kennedy and should any
questions arise that should require his intervention, 1 would appreciate your contacting him.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

ﬂY:1g
Enc.

�</text>
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                    <text>January 6,

1972

Accountant's General Section
Reckitt &amp; Colman
Household Division
Danaon Lane

Hull, England
Dear

Sir:

chloride.

We

We

have received the supply of diprenorphine hydrohave not received a bill regarding charges for

this shipment. It

material, supplied

was my impression that this was research
by Dr. G. Blane for research purposes.

Should there be a charge, we will be glad to
pay
Please submit a specific charge in dollar equivalent.

Sincerely yours,
Max

Fink,

m.

Professor of Psychiatry

H!:ig

cci

Dr. G. Blane

it.

�</text>
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                    <text>January 6.

TO:

Dr. A. Proud-an

FROM:

Dr. Max Fink

SUBJECT:

Questions on

1)

K

5050 Prepoocl

1972

Fro. Dr. Borgnor

ﬂ 5050 but been shown not to reduce blood pressure or to

interfere with respiration. No EKG data is available.
is widely used in veterinary medicine and
is
it unlikely that cardiotoxic effects would not have

The substance
been

reported,

if

they occur.

have no data as to absorpoion of

2)

We

3)

Because man

istration.

3050 on

is the ultimate target, and
to obtain data from mammals as close to

anticipate going right
human volunteers.

we

4)

H

I

IV

from animals to

admin—

anxious

feasible,

studies with

do not know wuether the technicians at Woodard can give
for 1k days in the rat. I assume they will try and in

the event that it is not possible, I
subcutaneous instead.
Ming

we are
man as

oral

am

sure they will try

�</text>
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                    <text>'—

v“
w

m-rvr-w-v

January 14, 1921Dear

Peter,

you

Thank you

for your

two

letters.

I hope that you have overcome

illness-- it is a shame to miss the early classes, but I
will make these up.

your

know

that

The notes on the Clyde Mood scale were very helpful. I had
already compared the output to the placebo schles and was sure that
the CMS was helpful. Your suggestion of comparing the last five minutes
of EEG to the CMS is a very good one, and I will try to keep it in mind
as the data analyses proceed.

I have asked that you be reimbursed for your travel, and
due course.

.this should arrive in

Your notes about the start of the placebo paper are
good; but I am confused by the request for a return of the general
summary you left with me. The summary I read, I believe I returned.
I have made a folder on placebo/EEG/Irwin, and
is not there; nor is
does Bruce have it. Are you sure I did not return my
it at home; nor
copy to you ? If not, descibe it again, please. (I'm embarrassed,
because in the past I could always turn to kathy and she would
save me from an embarrassing memory 0.

it

Feb 1, and

We

Glasser has just appointed a research assistant to begin
I believe he will Spend much time on the problems as outlined.

shall see something

by mid-March.

Keep working and keep

well.

�</text>
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                    <text>January 14, 1972

Lal, Ph.D.
University of Rhode Island

Mr. Harbans

College of Pharmacy
Department of Pharmacology
Kingston, Rhode Island

&amp;

Toxicology

Dear Dr. Lal:
Thank you for your kind invitation to participate in
the volume, ”Drug Addiction w Experimental Pharmacology.” Our
data, relevant to the interest of your readers, was presented
in 1971 in Clouet's volume. As tne results of our ongoing
work are not yet in a form that will allow publication, I re—
gret we cannot contribute to your interesting volume.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig

�</text>
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                    <text>January 5, 1972

To:

Alfred Freedman.

FRUH:

Max

SUBJECT:

Proposal for Medical Students, Chavez and Schwarzfarb
for Cannabis Studios

M.D.

Fink, H.D.

The attached protocol has been reviewed and is feasible.
However, the taking of blood samples in volunteers requires
special care and will interfere with their cooperation. that
and I believe we should pay ”a bonus" for blood samples.

I.

Will you approve

2.

From ﬁn 18172, may

3,

May

this study?

vs allocate 3300-400 to pay
those volunteers for their cooperation?
In xiv! these

raquoated?

men and Dr. ﬂoodles

(They are
Thanks

MF:ig
Enc.

available).

the chemicals

�</text>
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                    <text>1%-“. w:- gun‘s." Erma,”

.,

.

.

.7, V‘A'

.

‘n

ﬁrwwu— rmu-AM .u.

.

.v-

,. "7117'"

.v,:v-..W mum-w-—w--.-—rpvav.—~v.zu~-.-w—

-—

wry.» nuvm-w-w-

'

.WW

ymWVw-W‘VW'MN—FY'

wan—"pm”

mummy-rt."

-..,.

vw.’

,.

.‘rw'wum

”me

v-rr

7:me

wmwmm‘wﬁrw‘w

January 4, 1972
Henry

Brill,

M.D.

Pilgrim State Hospital

Brentwood, New York
”mm-w

y-r

Dear Henry,

-Wrw...~w_

w
v

.w...

and

it

may

Rhea Dornbush brought

interest

you

as well.

article to my attention,
anticipate examining our subjects

the enclosed

We

in Greece with these observations in mind.

m'

my

best regards.

awrwwmm—vw

rm

1'

Sincerely yours,

—y-

"Wv-u-v-r,

v—wv-‘m—r'w

wwwv—r'

I‘mzlmrml

Max

Fink, M.D.

--

�</text>
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                    <text>January 3,

1972

Stanley Einstein, Ph.D.
Executive Director
Institute Eér tug Study of Drug Addiction

680 West End Avenue
York, New York 13025

New

Dear Stan:

’It was Kind of you to invite the participation of our
laboratory in tau Second International s'mgosium 0n urug Begundcnce
‘h
in Israel, Hay 28w31, 1972. it will be at honor to garticipaCC A.”
the panel on chemotherapeutic approacuos to treating narcotic addicts.
We will be able to éisCusa our experiencea since 1905 witn cyclazocine,
naloxone, £~alpua~acotylmetnadol, and methadonc; and we then snould
also Have some data on too newest antagonist formulations, naloxone
pamoatu, £~cyclazocine and BC 2605.

It will

participation

be

funds available for

with the

necessary,

h waver,

for the expenses of this
there being no

to be defrayed outside our Department,

travel or maintonance overseas.

airlines, it will require
“Should this prove

(After checking

about $1,000).

practical for the Sponsors. I will sand

the requested abstract promptly.

Sincerely yours,
“8X Fiuk’ “.13.

Professor of Psychiatry

MF:ig

mug.“ n»«.s~¢.¢.‘d.».sa‘

..».

.ml'af‘uti‘a‘ 4m

'
.

'

n

.,

.

n’

�</text>
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                    <text>m

-

nu.—

~.

0‘ -m—v' n
.

r—-.wt n
....'WI aw‘ WV

v

n.

..., m

u :m.

m

7'“ ‘7

mummy-u.W..." “aw—9.,” 9, AM'“
,

_

,

«pun.

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..._._~~..... ,

we.

,,r~.r--.ww.,.-

raw-«Wm

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go-

,qrw..~_,.p
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twvwv
,.. .
.

,

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m. 5,. w,.“r---

w

_....V

January 3, 1972

wwmlwu'r‘vav‘v-ww»

Jaffe

Dr. Jerome H.
SAODAP

u

n

‘wn‘

The White House

Washington, D.C.
v-wwnm

»«

.w-‘Fvw—

rrwW.

Deer

Jerry,

In an interesting discussion with Dr. Cameron of the W.H.O.
in Mexico City, I was alerted to the possibility that Paul Jannsen
may have some potent and long acting narcotic antagonists. I wrote
to Paul and his answer is enclosed.

I plan to be in Europe en route to Athens between January

W—

v

I'Wr'

awrwrmw-qw

20 and February 10, and

will visit Janeeen at that time.

staff to accompany
It may be helpful for a member of your
have
indeed
some interesting
does
Jenesen
event
the
that
in
for
,
leads, these should be evaluated independently of any evnluation I

me
"I'm-IT."

"Jim-w"

may

make.

mun-r

my

best regards for a successful

1972

I

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

_

awwm—m”

1'"

‘7
mm.

-‘m'ﬁ'ﬂimrgrr

mf/

P.S. I am also enclosing e copy 01 a letter from Professor R. Mechoulem
of the Hebrew University. A1 Freedman interested him in the problem
of a formulation of naloxone for delayed release, end we supplied
him with some naloxone. In the event that you have e list of
potential research laboratories for this program, you may wish
to include him.
P.P.S.

What

is the status of the animal toxicology for

M—SOSO

?

.

u

.

.n— u..._‘.__.

”—77--

_

�</text>
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wwwmﬂwwvvrw-

——."—..Wv..v—.r~

«v.-

January 3, 1972
Dr. Paul Janssen

Janssen ?hsraaceutica
Beerse, Belgium

Dear Paul,

thanks for your letter of December 28. I plan
between
in Europe
January 20 and February 12, en route to
and
Athens,
will plan to visit your laboratories. I will write
Many

to be

or call and

make

the date more definite.

Because of the

potential importance of the study of
antagonists to the public health missions of our nation, I have
suggested to Dr. Jerome Jaffe of our special action office for
the President of the United States, that he send a member of his staff

with

me.

it is

If this suggestion is not acceptable, please advise

me.

his office that is responsible for the coordination of the
research efforts in the nation, any studies that may be undertaken will
be expedited if they are aware of the data at the outset.

As

My

best wishes for a successful

1972.

Sincerely yours,
Max

Fink, H.D.

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wwwmﬂwwvvrw-

——."—..Wv..v—.r~

«v.-

January 3, 1972
Dr. Paul Janssen

Janssen ?hsraaceutica
Beerse, Belgium

Dear Paul,

thanks for your letter of December 28. I plan
between
in Europe
January 20 and February 12, en route to
and
Athens,
will plan to visit your laboratories. I will write
Many

to be

or call and

make

the date more definite.

Because of the

potential importance of the study of
antagonists to the public health missions of our nation, I have
suggested to Dr. Jerome Jaffe of our special action office for
the President of the United States, that he send a member of his staff

with

me.

it is

If this suggestion is not acceptable, please advise

me.

his office that is responsible for the coordination of the
research efforts in the nation, any studies that may be undertaken will
be expedited if they are aware of the data at the outset.

As

My

best wishes for a successful

1972.

Sincerely yours,
Max

Fink, H.D.

�</text>
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                    <text>’

June

Ur. Aobert

r1.

30 , 1972

Rees

Corporate Medical Officer
Drug, Inc.

Sterling

90 Park Avenue
Jew York, how York 10016

Dear Bob :

Enclosed
As

as

is

a

project report of the £~cyclazoc1ne studies.

soon as we have mare

outlined.

material,

we

will extend the stud“:

We also have received the concentrated dC-cyclazocine and
expand
our studies to include 3 (or A) subjects to 20 mg cycle:will
ocinc. Our data on 10 sag cyclnocinc (extending antagonism to #8 hours

-

25 mg

heroin)

is

being ”written-mp".

Thanks again

I

for your

antenna.
Sincerely yours,
Fink, 3.x).
Professor of Psychiatry

Hex
21?:13

ﬁne .

�</text>
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                    <text>fl..-“

_

a- ”a

,

”a

.

..

.

.

_

,.

.___, _.,w___-.. a...

we“. "my.W_n-_m_,.m~__.v~.r..__mr.,__ amm,ww~—w.-—".-.wwwrw_.—n.—wmmmm

.

I
5

June 29, 1972
Jerome Levine, M.D.
Head, Psychopharmacology Research Branch

National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Jerry,
The

are enclosed.

additional copies of the progress report for

MH—13358

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

V

�</text>
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                    <text>Ref: 72-326N
June 28, 1972

Alfred

C. Ling, M.D. Ph.D.
Ciba-Gcigy

Summitt, New Jersey
Dear Dr. Ling,

Thank you for your favorable consideration of our
subvention of a report on GP—41299, to be published in
for
request
Arzneimittel—Forschung. I have written to the diitor indicating

this support.

I trust the report will be useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Ref. 72-325N

June 28, 1972
Dr. med. L. German

EditionCantor

KG

796 Aulendorf

West Germany
Dear

Dr. German,
We

are pleased that you have considered the publication of

our report, Clinical Evaluation of GP—41299, with favor. We can
reimburse the journal for the additional costs of earlier printing,
and understand that the cost will approximate 1400 DM.
Enclosed

ability in written
translation, and I

on our

behalf.

Many

is

an English summary of our

German

would

report.

Our

is insufficient to provide an adequate
appreciate an effort by one of your editors

thanks.

We have found a number of interesting reports in the
Arzneimittel-Forschung which have been helpful to us, and we would
be pleased to share our experience with the pther readers of your

journal.

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>review- www.mmmemm

'w‘ww.

r

Ref: 72-324N

June 28, 1972
George L.

Fite,

Senior Editor

JANA

M.D.

Chicago,

Illinois

Dear Dr.

Fite,
As an

60610

addition to the

letter

on heroin maintenance whieh

you will publish, it may be useful to add three citations,
to give the scientific readers the opportunity to refer to the sources

you

indicate

of the statements.

At the end of paragraph 1:
At

the middle of paragraph 3:
and again,

l.

H

. . .

. . .

stuporous states." (1)

" . . . levomethadleZI) "

narcotic antagonists (3)."

Volavka, J. et a1. : Electrogrephia Effects of Diacetylnorphine
(Heroin) and Naloxone in Man. Neurogharm. g;587-593, 1970.

2. Zeke, A.

et a1.

Dependence.

: Levomethadyl in Maintenance Treatment of Opiate
J.A.M.A. 220:811-813, 1972.

3. Pink, M. : Narcotic Antagonists
1006, 1970.

I trust these

in Opiate

Dependence. Science 169:1005-

comments may improve the

letter.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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"

'v ., W- —--—- --——— .ww... --vn-

(“.mur

‘-""-"""‘l—-'

m.

...

..-«-

w'r-‘W'

a

.
..

-’W

w...

-........_.. v—n. .r .—.-_-—. We. -mw-.——w,may"..-

r—‘Wuwmw

.

e

.7

~

..—~_‘..

1

Grants and Contracts Management Branch
National Institute of Mental Health

5600 Fishers Lane
Rockbille, Maryland 20852

Re: BSM 42-70-98

Dear Leo,

Since March, we have continued the studies under this
Greece. we wished to sustain the 'team', and we were
in
contract
encouraged to do so by the interesting data they generated.
1. We authorized the following additional expenditures
under the subcontract:

III B-l

3—5
3—3

3-6

Salaries
Patient fees

Laboratory costs

EEG

costs

$

7200.
1500.
280.
310.

2. In December, 1971, we approved a visit by Costas Stefania,
M.D., the project leader in Athens. He visited New York and Washington,
giving us an opportunity to review the data and plan the next phase of
the studies; and reporting to the staff of the Institute of his
findings. He submitted a statement of his expenses for Athens-New York$825.
Washington-New York Athens in May.

latest

voucher (07, dated June 16, 1972), we
requested the balance of the funds under this contract, and found that
the balance left for overhead transfer was insufficient by $ 1,222.
3. In our

The

w.

.,,-

‘

June 28, 1972

Mr. Leo Sanders

-.

ﬁve—«.m-

-

Ref: 72~327

vu—w—rvw—m-v—pm—r—~—wv——..—mmmmmuw—Iw—_W.W,

._,

—-—-mwm—w w-vww.-m\~-w"Jr ~-m..W.-_..—.;-

«n—

pilot

EEG

data collected this spring

was analyzed

in

York, using machine time and personnel supported by NIMR grant
ME 18172. Such additional costs, as well as supplies, incidental
fees and travel, are not reimbursable.
New

My

negotiations.

thanks for your cooperation and understanding in these

Sincerely yours,
Fink, M.D.
Executive Director

Max

W.

m. m

—.—.m.......

�&lt;
.
v

MIMWV

m‘mm

m—«q—urW—FWV

WWW—'w—n

,wm_w

W"...

HSM

.. .w—‘mw'm

W,

.

.7 --_..).

W

,

,

Wm.

r..— Y

June 28, 1972

42-70-98

Explanation of Costs incurred

III B-l

3-5

Dru. Liakos and Boulogouris ($400 x 2 x
Miss Kokkevi (psychologiat)
Dr. Panayiotopoulis (neurologist)
Miss D. Gefou (Social worker)
Mrs. A. Liakos (EEG technician)
Mr. L. Bassiakoa (Research assistant)
Smoking sessions. ambulatory,
60 sessions at $25

3-3

Echo-EEG

8-6

EEG

8-4

Travel

(14

at

3

pilot assays

$20)

costs (62 hours at $5/hr)
(Athens-Now York-Athens)

months)

$

2,600.
1,050.
1,200.
1,050.

750.
750.

1,500.
280.
310.
825.

-

‘nf'! 1m—'-v--’

�</text>
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_

Ref: 72-321 I
June 28, 1972

Michael Beaubrun, M.D.

Professor of Psychiatry
University of the West Indies

Mona, Kingston, Jamaica

Dear Michael,

I regret that

we

have been unable to obtain a contract for
at this time. It seems that one hurdle
is permission from the State Department

the cannabis studies in Jamaica,
that we cannot overcome directly
to undertake these studies.

Two weeks ago, when we spoke, I called Dr. Smith at NINE
and assured him of the answers you gave regarding the premature
release of the data. Not hearing from them, I called the contracting
division last week, and was told that it was too late to support the
study this fiscal year. I called Dr. Bunney, and after some discussions

with others, permission was given to fund the contract out of this
year's budget-- provided State Department approval could be obtained.
When the question was raised in Jamaica, apparently, the negative response
was sufficient to push the discussions to the next fiscal year.
Should you wish to proceed, I would suggest you enquire of
Dr. Jean Paul Smith or Dr. William Bunney, for an official interpretation

of the status of the application.

would be prepared to write a letter to the Secretary of
State, indicating that this Association has had experience in Greece and
that we have a good record; that it would be sad for the program to be
We

aborted because of the misbehavior of someone over
cntrol, egg.

whom we

have no

Incidentally, the 'worksheets' prepared by Dr. Smith, Dr.
Szara, Miss Carroll, and Dr. Petersen are most satisfactory, and I do
believe they were prepared (or are prepared) to see the program through,
if the administrative hurdles can be overcome.
Regretfully,
Fink, M.D.
Executive Director

Max

p. rm“-

, "1..“

�</text>
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                    <text>ﬂag:

7v3w4/
June 27, 1972

J. Bellisri

Mr. John

Director
Bureau of Narcotic Control
State of how York
Department of Health
84 Holland Avenue
Albany, ﬂew York 12208

hr. Bellizzi:

Dear

I am writing with regsrd to Certificate 2984. issued to the
Psychiatry hrug Addiction Unit st 1901 First Avenue as s Class VI

-Registrent~ﬂethsdone Haintensnce Program.
We

Scientific
(1)

request re-designation as Class VI:

and Medical Research.
We

are not a methadone maintenance

Laboratories for

facility.

treat more patients with methadone as part of their
we also use group therapy, narcotic antagonists
but
psychiatric care,
(cyclazocine, naloxone. 355.), use heroin for experimental purposes,
(2)

and

We

do

test methadols.

hold

we do abide by FDA regulations, for methadone but also
for levomcthsdyl, nsloxone, L-cyclezocine. etc.
While no special regulations apply now. I anticipate that

IND

(3)

Class VI « HIP

will

be

restrictive

broader Class VI: Laboratories
Metropolitan Hospital.

—

and request re~designstion to a
both at 5 East 102nd Street and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Mex

Hing

�</text>
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Ref: 72-316N

June 27, 1972
Robert

M.

Derman, M.D.

Veteran's Administration Hospital
New York City 10010
Dear Dr. Derman,

Enclosed

consultant at the

vitae.

is a completed application for the position of

V.A.

in

New

York, and a copy of

my

curriculum

In February, I was appointed consultant to the V.A. in
Montrose, and I have requested Dr. Harris of Montrose to send a
your attention.
letter indicating that this was indeed accomplished,to
V.A.
allow
the
to transfer
will
the
that
appointment
earlier
I trust
the appointment to New York, and avoid the extra effort in process-

ing.

Today, I spoke to Sam Kaim who indicated that he had
received support from SAODAP for the collaborative studies, but had
not received answers to his request for additional supplies of

levomethadyl.

My

thanks for your

invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Ref: 72-323

SB

June 27, 1972

Stanley Yollea, M.D.
Department of Psychiatry
SEXY-Stony Brook

Stony Brook,

New

York

11760

Dear Stan,

In checking the events at Montrose V.A.

this winter, I find
and that this
appointment was approved in Washington. Enclosed is a copy of that
application. Dr. Harris at Montrose has the file and can write the
that they did appoint

appropriate

I

me

a Consultant

in Psychiatry,

letter.

Perhaps this will make

have sent the same to Dr. Derman

methadyl study.

I shall be at Raquette

my

appointment to Northport easier.

at the Manhattan

on August 1 and

for the

lava—

for July. Should the
office in New York;
York. I expect to
will call your office that week.
Lake, N.Y.

occasion arise, you can reach me by calling
or writing to Genereal Delivery, Long Lake,

return

V.A.

my
New

Finally, the Greek cannabis study will be funded; the
Jamaica was sunk by lack of State Department clearance; and Jerry
Levine has yet to answer me-- I will call him at the end of this week
again.

Hy

best to all.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>.,_, ..

ww‘nw—

,

NV

.q...

,

;
g

E

Ref:

72—322

June 26, 1972
Morris B. Bender, M.D.

Professor

Chairman

&amp;

Department of Neurology
Mount Sinai Hospital
100

New

Street and Fifth Avenue
York City 10029

Dear Morris,

the Presidency of the
attended the meetings
It seems like
There are
found
and
discussions
rewarding.
so
of the Association
its
times when I regret that my path for research led me away from the
sure diagnoses in neurology and the clear images of the PEG and the
arteriogram. Surely, the squiggles of the EEG are a far cry from the
images on the x-ray.
But, I am also writing to congratulate you on your address-which was reported to me as a tour de fbrce.To have found an under—
standing of acupuncture in DSS is magnificent, and should the ensuing
research prove your hunch to be correct, it will provide a new impetus
to the research you so ably fostered.

ANA

hope

on your election to
so many years ago that we

Congratulations

I

that

regrets at not attending the meetings in Chicago-- I
will be able to meet again under such favorable conditions.

My

we

My

best regards to Sarah.
Sincerely yours,
Max

P.S. Thinking of the past reminds
Have these been discontinued

me
?

of the

Fink,

M.D.

Israel Strauss lectures--

�</text>
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                    <text>June 26, 1972

Jack Enroll, ﬁ.D.
The

Fsychiatric Institute

2141

K

Street.

H.W.

Washington, D.C. 20037
Dear Jack:

Enclosed

is

an

abstract, marijuana,

Habhion Md Tetaahydhocau—

nabinoi-l-% Eééecxé on tEG, Heant Rate, and mood, for your consid«
oration for the October meetings of the Psychiatric Research Society.
The report will daocribe dosenrelated EEG, heart rate and self~report
effects, witha focus on the relations of brain changes to behavior.
Suould you wish, Peter Crown will
by a song ”The Talking Killer Weed Blues”.
'l'he

illustrate the

presentation can be made in 20 minutes, but
for discussion. thereafter.

an opportunity

Sincerely yours,
Mux

Fink, 3.0.

Professor of Psychiatry
nF:ig
Enc.

mood

we

effects

would enjoy

�</text>
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                    <text>306‘7 . {so

géfaﬂuuggei

Ref: 72-3103

June 24, 1972
Derek Quantock, M.D., Ph.D.

N.V. Organon

Oss, Holland
Dear Derek,

We are progressing with our studies of intravenous OI~63.
In the present assays, we are using 15 mg doses, and for these subjects,
we are not finding the behavioral changes we obtained some months
ago. One thought, is the possibility that the samples I have left,
may have deteriorated; the other, is that our earlier assay was an

error.

I do not know how long it takes to make up, and to ship
additional supply of 01-63. But, I would like to re~do some
subjects at the end of this run, and for this purpose, will need
400 mg OI~63, in ampules of 10 mg each (if that is possible); or
the equivalent in the available lgfmg lots.

an

Many

thanks.
Sincerely yours,
Max

P.S.

My

trip to

One. I

Copenhagen

in

August

will write before then

Fink,

MD.

will include a side—trip to

when

I have the details before

me.

�</text>
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                    <text>M E M O R A N D U M
_——————.—~-—-«-——.

June 23, 1972

To:

Irv Schwartz

FROM:

max

Fink

I have reviewed the personnel previously assigned to the Psycho~
pharmacology Clinic and the various budgets. I believe the following
assignments provide for the continuation of programs, and a proper

utilization of funds.

Miss Sonna burbin and Miss Doris Giordano: These two research
nurses are devoting more of their time to the drug abuse service.
They are budgeted on 47—072~7. Dr. Levine has indicated that Miss

Durbin's time is now almost fully occupied in the drug abuse program,
and her assignment should be clearly designated as part of the addic~

tion program.

Miss Giordano has committments to the BCT program, and as Dr.
Taylor implements his lactate program, he may wish to utilize her
time. I suggest she be reassigned to the clinical services, and her
salary be paid from the new grants awarded to Drs. Taylor and Abrams
(to the extent they wish to use her time), and in part to that budget of the clinical services that support the treatment program,
notably ECT. The researdh aspects of ECT are no longer funded as
a separate project.

I endorse the request of both nurses (attached) for a review
The job descriptions should be modified slightly,
but both have exhibited a flexibility of assignment and a willingness
to assume reaponsibility that has been most useful. (Appropriate
of

their salaries.

levels

may

be $12,700 for Miss Durbin and $11,500 for Miss Giordano).

�Jr. Irv Schwartz

June 23, 1972

Pedro Gaztanaga, H.D.: He is working full time in the training program. It seems to me that if his salary is to be paid from
47~O72—7, we should assume he will have some relation to the addici
tion service. At present, there is no opening. Should the training
division wish to use his services, a fair guid pro guoﬁwould he the
assignment of residents, in rotation to 15A, on an equal basis with
residency assignments to 13A or 133. Lacking such a rotation, I fail
to see the justification for the use of these fund (47—072—7) to sup—
port clinical teaching away from the drug abuse treatment unit.
The remaining assignments of personnel and budgets of 15A seem
appropriate to me, (iiEia 47-072—7 and the personnel assignments of

the

15A

Addiction Treatment)units).

�</text>
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                    <text>June 23, 1972

Dr. S. kanowski

Freie Universitat Berlin

Nussbaumalee 36

1000 Berlin 19,
West Germany

Dear Professor Kanowski:

I

am

most

interested in your studies of blood levels of Perzin

years ago, Itil and I tried such a study of
failed to find a correlation but thought this may
butaperazine.
have resulted as much from the problems of measuring blood levels
as from the EEG measurement. In our studies of cycloserine, we did
find blood level n EEG correlations, and others have reported similar
correlations for lithium.
and

EEG

effects.

Some

We

The

reports

you requested, and some others which may be rel—

evant, are enclosed.
Many

thanks for your

interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                  <elementText elementTextId="106438">
                    <text>Ref.

72—3115

June 23, 1972
Drs. G. Dolce and
E. Merck

K.

Offenloch

Darmstsdt, West Germany
Dear Drs. Dolce and Offenloch,

I am enclosing a draft of s recent report from this
laboratory, as presented at a meeting of the Drug Information Assoc-

istion.

August,

it

meetings in Copenhagen this
visit to Dsrmstsdt either
The meetings are scheduled for August

As I plan to attend the GIMP
may be possible to arrange a

before the sessions or after.
13-17.

Should such a
my

visit

be convenient,

please advise

me.

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>.

-

-

-

-*

'2'~*&lt;-&gt;~&gt;

--

mun—m

:w..w—,..wmu.w.m.w «w “n"‘m ”mm.wv—vw'v’-—q7vx~

p..." .,,-.....,.

,,_,__

a... m’lxk'ﬁw—W

1.“:r-,..,..~,~m~-_—.-..—r..~.r»w.r

Ref: 72-301N
June 23, 1972
Mrs. Roberta London
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590
-Dear Mrs. London,

with

much

first

issue of Cbntemporary Drug Problems
interest, and found much that was new to me. I hope you

I read the

will be successful.

I have read the articles by Samuels and by Hochsteeter. They
are disappointing. Both are vague polemics, hoping that drug delivery
problem.
will, in some undefined way, solve the Opiate dependence
Neither provides answers to the technical issues with which we have
how to select patients; how to deliver drug safely;
grappled——
what about spillage; what is the duration of the treatment; etc.
More important, neither gives a clue as to their view of the etiology
of dependence and how heroin delivery will serve the patient, or
even society. Perhaps the third paper is better-- I should like to
read it if I am to provide a commentary, which I will do gladly. Can
you send me the San Francisco report ?
Yes, I should be pleased to participate in a panel discussdon
on heroin maintenance. I will try to bring to it the technical issues
which seem so complex, the problem, of 'after heroin, what then?', and,
so as not to be wholly negative, some alternate solutions based on
a different view of the etiology of drug dependence. I do not know
whom else you are considering for the panel other than the well known
advocates (Vera representatives, Samuels). Have you thought of some
official points of view, as that of BNDD (Haislip), SAOBAP (Jaffe or
Kramer), NINE (Bunney or Petersen), and the Marijuana Cpmmission

(Brill)

?

Good

know

it will

luc} in your

succeed.

new

venture.

It

serves a need, and I
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>EEEQEAEQEE
June 22, 1972

To:

A. M. Freedman, M.D.

FROM:

Max

SUBJEC":

Proposal, ”Effects in Man of the Chronic Administration
of Hethadone or Cyclazocine“

Fink,

M. u .

proposal is an experimental study in addicts, involving
tongue biopsis and infusions of methacholine and Zenorephrinephrine
to define cholinergic effects of methadone (or cyclazocine). The
study bears no direct or indirect benefit to the subjects.
The

proposal alludes to some experimentation data on the mouse
and salamander, but it is not clear wnat the relevance of these data
The

for

man may

be.

author treats methadone and cyclazocine as if they were
equivalent drugs. For example, what print data was obtained in
animals with cyclazocine?
The

The protocol is incomplete. How many subjects, how selected;
and by whom? What will be paid the addict volunteers? If not paid,
what benefit will they get? If any is part of treatment regimen,
who is responsible? What will be done with the samples?

infusions are cited but for the protocol, we do not know
how subjects will be selected; who will be present, what duration
and what criteria for the end of infusion. What of the blood pres—
sure effects? How will vagal effects be assessed and how will subjects be protected?
The

In

sum,

the protocol is incomplete, particularly as i
’

to the selection of subjects and benefits for subjects

ting.

�</text>
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                    <text>94‘; 11"}uu

M

June 22, 1972

Jerome Levine, M.D.

Chief. Psychophareacology Research Branch
National Institute of Mental Health
5600 Fishers Lane
Rockville, ﬁerylend 20852
RE: 'MH

13358

Dear Jerry:
Enclosed is a detailed summary of the studies in the program,
and Human Pégchophadmacoiagy, since January 1, 1971. This
should
provide summaries of the activities since the renewal application
summary. I have also outlined the studies now in progress and the
EEG

anticipated continuations after transfer to

Stony Brook.

There are some funding problems for the coming year. I have
developed a talented and well trained staff. Each is loyal and en—
thusiastic about the program and desires to move with me. What I
an not sble to face is that not all ~~ indeed only a small part of
those working on this program ~ are paid from this grant. The other
budgets remain in New York City. and I find that a realistic budget

to sustain the effort and pay for transfer and renovation is closer
to $90,000 for the first year
or until each a time as I can assign
their services, in part, to other programs. (Part of the delay in
sending this summary is based on my attempts to obtain additional
funding for this transfer).
——

Nevertheless, I believe I can sustain the program and I enclose
for the transfer year for $60,000.

on pages 20-22, a budget

�June 22, 1972

Jerome Levine, H.D.

I have also added eoee coenente for the continuing years of
to write, for I
the program. These latter were the moot difficult
ECDEU
supeort for this
believe that I should anticipate closure of
of the reviewers
comments
program, reflecting my perception of the
sustained this
have
period. I
for the continuetiou for this project
1960.
ECDEU
since
It is tire to
effort for PR3 since 1957 and for
in not
selfish
sometimes
I feel
summarize what we have leerned ~~
should
and
closure
hove
learned,
having ehered the details of whet we
provide the impetus.
however, the program is to go forward after three years,
197‘.
the decision should be anticipated in 1973 or the first helfendof that
consideration
There are two suggestions-which deserve your
the
of the Peychopharmecology Coumittee. It may be useful to have work—
a
end
convene
to
academic review you suggested in ﬂexico City;
of this diegrowth
the
in
who
have
participated
of
scientists
shop
relevant
to clin—
cipline. To both, we could address the questions
for
your pro~
ical psychopharmacology and provide additional inputs

If,

grommatic

decision.

Should

Stan Yolles

it
has

program to Stony Brook,
by the Inter—
administered
be
the grant

be pooaible to

agreed that

transfer the

Box 269,
national Association for 9eychiatric hesearch, Inc. (P.0.
is
possible
We
urge this, because it
Great Neck, new York 11022).
from
that Association if they administer
additional
support
obtain
to
the project.
I am most grateful for your support and interest these many
continue
years, and truat that your faith, and that of Jon Cole, will
to be rewarded by the results of these efforts.
Sincerely yours,

ﬂax Fink,

e'ieDe

Frofessor of Psychiatry

Hing

�</text>
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                    <text>June 20,.1972

William.Guy, Ph.D.

ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 ﬂuff Court
Kenoington, Haryland 20795
Dear

Bill:

I have read the various mohk~ups of scales sent on June 12.
the extant it is possible to review these outside the laboratory
situation, I have done so.

To

The
11

RPR

seems

satisfactory.

The FMS is an interesting addition. It is not clear whey item
is requested. These items may be significant only in relation to

concurrent illneoaes or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
to use.

The 90138

is

an

interesting change,

TESS, Data Shipmont, and 93E

satisfactory.
We

should have

that

seem: easy

in using these forms,

Sincerely yours.

1,1“. 5.9.
m
Profoooor of toychiatry
“3:13

‘

are difficult to asSess but seem

littlc difficulty

anticipate thoir inplouontatian.

and one

and

�</text>
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                    <text>Juno 20, 1972

G.

F. Blane, Ph.ﬂ.

Reckitt &amp; Colman
Hull, England
Dear Gary:

Enclosed

is

an

official

U.S. import permit #3349

diprunorphine, for our annual assays.
Thank you

for

for your cooperation.
Sincerely yours,
Max

Fink, d.D.

Profnssor of Psychiatry

3F:1g
Enc-

’

15 grams

�</text>
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                    <text>June 19, 1972

click
32—15

Long

Book Binding Company

37th Avenue

Island City,

New

York

Gentlemen:

three volmes of EEG Gun. :Jemphyséoin which
would like to have bound in nation with gold lettering.
Enclosed

we

an

Lettering should read:
£30

EEG JOURBSAL

V01.

1971

30

'

JOURNAL

Vol.

31

19 72

EEG JOURNAL

Vol.

32

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming, purchase order

will follow.
Sincaraly yours ,
ﬂax Fink. 24.3.

Proton-or of Psychiatry

iii : is
Enc.

�</text>
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                    <text>Q,

l":

June 20, 1972

William Guy, Ph.D.
ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 Huff Court
Kensington, Aaryland 20795
Dear

Bill:

I have read the various mohk—ups of scales sent on June 12.
the extent it is possible to review these outside the laboratory
situation, I have done so.

To

The

RPR

seems

satisfactory.

My

an interesting addition. It is not clear wheytitem
II is requested. These items may be significant only in relation to
concurrent illnesses or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
The

to use.

PMS

is

The DOTES

is

an

interesting change,

TESS, Data Shipment, and DSE

satisfactory.
We

should have

and one

that

seems easy

are difficult to assess but seem

little difficulty

anticipate their implementation.

in using these forms,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

and

�</text>
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                    <text>June 19, 1972

Click Book Binding Company
32-15 37th Avenue
Long

Island City,

New

York

Gentlemen:
we

would

Enclosed are three volumes of EEG Cﬂin. MauKOphyA£0£., which
like to have bound in maroon with gold lettering.

Lettering should read:
EEG JOURNAL

Vol.

1971

30

EEG JOURNAL

EEG JOURNAL

Vol.

Vol.

31

32

1972

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming purchase order

will follow.
Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry
Ming
Enc.

�</text>
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                    <text>June 16, 1972
Walter Essman, Ph.D.
Department of Psychology
CUNY-Queens College

Flushingn New York

Dear Walt,

Enclosed are two checks from the New York Medical College
representing consulting fees for the period ending April 30. If my
calculations are correct, we are now "current" with the payments from

the Association.

I am obligated to leave a 'clean' grants situation at
in September. As I mentioned, I am able to support some of the
studies in the biochemistry of CSF in ECT in relation to the balance
available to me in the ECT grant. Unhappily, these funds are limited
and I can sustain the relationship until the fall. With regard to
Mrs. Heldman, as we have no reasonable support in the offing, I will
ask that she be transferred tp other funds available to you, effective

NYMC

August 31.

I have discussed this with Dick, and ehile he is willing
to continue collection of samples and freezing them, he will discuss
with you the most feasible ways of continuing his work.
My

holidays during July will be spent in the Adirondacks,

My

best regards.

and I can be reached through my office. I will return about August 1
and we can discuss the future work and the data of the present studies
at your leisure. Also, should it be possible, I would appreciate
your reaching Rhea to see what can be made of the cannabis data.

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>"liq“.- .

“ﬂﬁﬁm
‘,"',.'I

.J
m

E

-‘

Hit

533%?“

1‘

Jun. 16.

“sm-

3-way?

1972

l1"?

"

E

-

Lr.;n"_¥§t.

J»

E
7&gt;'
"v

j

"‘1:."“I"“"~iﬂm.

'.

Hr. Robcrt Cuddihy

2‘:

Drug Information Bulletin
Sandoz Pharmaceuticals
Hanovor, New Jersey 07936

:Lr

':&amp;‘LmiL-fzi..L-’;JZ
,“,.-~.‘

A

Dear Mr. Cuddihy:

Enclosed at: two copies of the report ”Quantitative EEG
as a ﬁensure of €88 Bioavailability of Paychoactivo Drugs", which
was presented to the DIA in May, and which is submitted for your

considoratton for the

Drug

Information Bulletin.

Sincerely youro.
ﬂax Fink, H.D.

Professor of Psychiatry

KF:13
Enc.

fur-‘1’,

�</text>
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                    <text>June 16, 1972

Exacuttvu Sacrutarial

International Symposium
Clinical Pharmacology

Pontiach

on

345

3-84 Eagensburg

West Germany 1
Guntlamen;

I obtain the noceanary rugistratiou information and
preliminary prograus for the moctings scheduled August 10«13. I
have submitted an abstract to Professor E. Garrett.
Hay

Thank you.

Sincerely yours,
Fink. ﬁ.ﬂ.
Professor of Psychiatry

Hex
MF:1g

�</text>
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                    <text>June 16. 1972

Profossor Edward Garrett
University of Florida
Gaineavillo, Florida 32601
Dear Professor

Garrett:

In March, I submitted an abstract for your consideration
for tho Intornntional Symposium on Clinical Pharmacology 1n Regen8~
burg. I havo received no further information, and am writing to
inquire what programming decisions hovo been made.
Romy

thanks.
Sincerely yours,
Ha: Fink. M.D.

Prof-330: of Paychtatry

ﬂf:1g

�</text>
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                    <text>June 15, 1972

Mr. John Mcﬂiff
334 ﬂowery

Apt. 7F

New

York,

New

York 10012

Dear John;

I regret your decision to leave, for I do believe that you
contributed to the success of the program. but, as Bob and Bruce
are finding their way in other educational programs, I am sure you
will do well in yours.
Good
many

years.

luck in your studies, and
‘

Yours

Max

my

thanks for your help these

truly,

Fink,

M.D.

Professor of Psychiatry

HF : 1g

P.S.

We

will send your check, including earned vacation to the

address given.

�</text>
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                    <text>-

,.

.«w—v'7' —u w'—"uw

A

n.

7*“ may

June 15. 1972

John m. Davis, M.D.
Department of Psychiatry

Vanderbilt University
School of {wiediclne

Rashville, Tennessee

37232

Dear John:

I have read your letter, "Chotinekgic Revenbaz 06 Manic
Symptomo" in the Lancet of June 3 with much interest. The role
of cholinorgic mechanisms in depressive states ané their treatment
has been ignored for too long, and such data as you present is most
role of cholinergic mechhelpful. Some years ago, we reviewed the
we were intrigued by
ECT.
of
by
depression
anions in the relief
diethazinc,
benactyzine,
of
cnticholinorgics
(g;g.,
the ability
such
physiological
ECT
(and
induced
improvement
Ditran) to reverse
I am
EEG)
states.
and
depressive
the
to
exaggerate
indicer as
thooc
otudiea,
summarizing
of
a
reprint
enclosing
the
taking
liberty
own.
complcmentary
to your
as
But I am writing because I am particularly interested in
your comment, "... that norihuann*induccd euphoria and talkativencss can be converted to a severe depressive syndrome by phyoostig~
mine". I do not recall these data at the APPA meeting. and I am
to
writing to ask if a copy of that report can be made availablewith
interactions
by
of
effects
of
The
method
drug
analysis
us.
known pharmacologic agents is one that we have just begun to apply
to our studies of cannabis.
ﬂany thankn.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

ﬁfzig
Enc.

�</text>
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                    <text>June 13, 1972

Mr. Gary Boyer

Biomedical Section
Cancer for Studies of narcotic
and Drug Abun-

ﬂotional Institute of Mental Heolth
5600 Fiohoro Lona

Rockvillo, Maryland

Dear ﬁr. Boyer:
A~9, and

Our ongoing

v.3.

~ NINE

studios of cannabis ~ comparing hashiah THC~
marijuana in Greek chronic bookish unors re—

quires additional supplies of marijuana (35 grams. 2.6x

THC~A-9)

and IEC~A~9.

Pilot studies on these subjects for other constitunnts or:
in progress, ond so request additional amount: of THC—A—s, CBN, and
GED.

The appropriate Bab—2226

my

is enclonsd.

thanks .

Stncoruly yours,
Max

Pink,

211.1).

Prof-user of Psychiatry

Mrzig

Sac.

�</text>
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                  <elementText elementTextId="106445">
                    <text>r7.

.

,

~.,.'.._._.~mmwvm-v '3'".

WWﬂW—v—m

-

-

-:2-

~—

,

w'mr‘wnwn‘n

unwahilmw'rwnw‘m‘m‘r '7'“, w": .m

Wynn“.

June 12, 1972

—

r”

w—,

"cw-nun

m,-

F. Gilbert McMahon,M.D.

Department of Medicine
Tulane University School of Medicine
New

Orleans, La.

Dear Professor McMahon,
Thank you for the invitation to participate in the
symposium, Clinical-Pharmacological methods of Drug Evaluation, to
be held in New Orleans next March. I will be pleased to participate
and to discuss the role of EEG methods in new drug evaluation and as

indicies of bioavailability.

In your outline, you indicate the other titles to be
reviewed in the session. If it is of any help, I would suggest you
consider Milton Kletzkin, Ph.D. of Wallace Laboratories, Cranbury,
New Jersey for the review of skeletal muscle relaxants. If he is
unable to carry out the assignment, I am confident he will be able
to recommend someone to you.

Similarly, Dixon Woodbury is well known for his interest
in the anticonvulsants; or, possibly you would wish to consider one
of the more classical neurologist-clinicians as Gilbert Glaser or

Melvin Yahr.

fall,

may

As I will be changing my university affiliation this
I suggest that my address of record he changed to:

P.0.

Box 269

Great Neck,

Communications addressed to

Again,

my

that

New York 11022
box should reach me promptly.

thanks for the

invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Juno 3, 1972

T0:

Billie Jones,

FRDH:

Max

SUBJECT:

Freeing of ﬁrs.

M.D.

Clhnical Director
Fink. H.D.

Thomas From 15A

On my return from a trip I find
Mrs. Thomas from 15A to another service

that you have tranaforred
at ﬁetropolitan ﬂoaﬁital

at a higher salary. effective immediately.
I

am

pleased that you think so well of

staff to seek her services, for I

know she

a member of

the

ISA

is capable. I even ooro

dolightoé that you ovaluato her sarvicaa as worth about $5,000 more
we are paying her.
I have indicated to Mr. Schwartz, on prior
occasions. that the staff ware grossly undorpaid, and your evaluation
than

confirms

this judgmont.

While I am grateful for your confidanco, I am aware that
Mrs. Thomas is directly roaponaiblo for patient care. until we
have an adequate roplacaonnt. I have asked her to continue to oervo
15A. I know that you will agroa that bar promotion in work duties
ahould wait upon a roplacanant, for otherwise tho patients will
suffer a loss of care; but that Mrs. Thomas does not suffer for her
unuaual capacity and rocogniaing your judslant, I am asking ﬁr.
stowartz to pay her new salary ottoctivc innodiatoly.

Again, I thank you for your confidant. in our

cc: 1.

B. Schwartz
Mr. M. Thomas

or.

x. Koanick

Dr. R. Levine

staff.

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                    <text>w."

WWM',

June 7, 1972
Mr. John A. Hamilton
New
New

York Times
York City

Dear Mr. Hamilton,

1

I very much appreciated your balanced presentation of
the problems inherent in a heroin delivery research project in your
article, Free Fix fbr Addicts ? on June 5. In addition to the problems
described by Drs. Jaffe, Dole, and Phillipson, we should add the special
risks of heroin administration. In our studies at this center, we have
used 'heroin challenges' as a specific index of the duration of action
of narcotic antagonists. This experience has brought to our attention
that intravenous heroin has effects on heart rate and the EKG; on
cerebral rhythms (exciting seizure activity sufficient on at least three
occasions to precipitate a grand mal convulsion); and on respiration.
The sequence of events are often unpredictable, since the men vary in the
degree of the induced cross-tolerance to opiates they have developed.
Even in the laboratory, there are problems; we are not sanguine about
a large scale delivery system.
Indeed, rather than seeking the use of shorter acting
opiates, as heroin or morphine, there is logic in seeking opiateelike

with durations of activity longer than methadone. Levomethadyl,
the l-alpha-acetylmethadol, is such a substance. Instead of seeking the
use of a short acting substance, the leaders desiring to innovate might
do well to look into the greater use of this substance: by providing a
longer duration of cross~tolerance, dosages must be taken only three times
a week, reducing both the problems of irregular intake and that of
'seepage' of illicit materials into the community. Levomethadyl is
also taken orally, as is methadone.
compounds

Again, I wish to commend you
heroin delivery recommendations.

on a reasoned view

of the

Sincerely yours,
Fink, M.D.
Professor of psychiatry

Max

�</text>
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                    <text>Jun. 7,

Jean Paul Smith and Alisa Runs

To:

1972

,

national Institute of Hental gtzicn

5600 Fishers Lane
Rockvilla, Maryland 20852
ﬂax Fink, ﬁ.D.

PROM;

SUBJEDv4

4

Drug Use:

harcotic Addiction

Program

During 1972-73, the SUNY~Stony Broot Drug Abusa ptogram.will

examine tha usefulness of cyclazocinc in their treatment of opiate
to methadone and leVumethadyl. In this
dependence, and compare
study. diacetylmorphine will be used in “heroin h lleuges” to mea—
sure tha degrea-of blockade (to éefine adequacy, duration) and to
demonstrate the potency of these substances as a 3tep in the decon*

it

.

ditianing process.

(1) nglggggigg. After detoxification, patianta will be
1ndt¢tod to h—6 mg. cyclazocine in 4~6 days. As an antagonist to
the agent-tic features of cyclaxocine, naloxone hydrochloride (0:31)
600 mg. q3h; prr.n. will be availabln for the 4»6 days of the in—

duction period.

�Jean Paul Smith

8

Allan

2

June 7, 1972

Romany

Following the ptovailing high dose roginono,
on will induct patients in 20—40 days to 100 mg. oral daily. (Should
it peeve hooful, we may adfpt a low dose (50 mg/dly] schedule).
(2)

Mothodono.

0

Induction to 80 n3. thrac
in plannod.vith tho induction poriod of 6 weeks.
(3)

v. will

Levomothadz .

tin“

a week

(b) Heroin Chgllongo . Following our doocribod nethoda,
use intravonouo heroin (20,30 ng/lcc onlino/luiinutc) when

subjects at. drug-fro. (to dotino heroin response) and whom induction
to cyclnxocinc, levooethadyl, or nothodoln 13 achiavod, to define
efficacy and duration of blockade, and b» {novide a basis for do—
conditioning.

mueaﬁﬁeﬁem
Based on 50 patients receiving cyclazociné, and 45 each on
methadone and levomethadyl.

6: 90

liters,

Cyclazocine:

36

Naloxonoﬁ

240 grams (800

Methadone:

500 grams (powder)

Levomethadyl:

150 grams (powder)

Heroin;

10

grams

grams

tablets,

(powder)

2 mg/Scc)
300 mg each)

/

�Joan Paul Smith

&amp;

3 _

Allen Ramsay

Juno 7. 1972

CITAIIOHS

Haloxonn Paloata: A Long~Act1n3 Opiate Antlgoniut, (submitted for
publication). (R. Lavina, A. 23kt. I, A. Frudlun).

Luvoanthadyl 1n Haintenanco Trcatncut of Opiatc Dopendcnna.
(A. Zaka, f, A. Froodnnn).
Duration of Hathadon. Induced Crocc~Toleranca to attain.
Addict. 66: zoswzos. (A. 2m, 9. A. M. Kama-nu).

84.

J.A.%.A.,

'“

I

J.

Cyclaxocina Therapy of Opiate Uepcndcnca w &amp; Progress Report.
Compachenb. Psych£a£., 12: 491‘502, (R. Rasnick, 3, and A. M. Freedman).
A

Rational Therapy of Opiate Dependence:

Amen.
and R.

J.

NuAéLug, 71:

Maniac) .

1359-1363.

Harcotic Antagonists.

(with A. H. Frocdmsn, A. inks,

Naloxone Traatment of Opiate Dependence.
(A. Zaks, T. Jonas, A. ﬂ. Fraedmnn) 5).

J.A.M.A., 215:

2108*2110.

Cyclarocins Typology in Opiate Dependence. Amen. J. 7&amp;ychiat.,
1256-1260. (B. ﬁesnick, # and A. H. Freedman).

126:

Intravenous Qiacetylmorphina (Heroin) in Studies of Opiate Dependauco.
Ned». Syét. Supp£., 33: 89~92, 1969. (A. Zaka, A. Brunet, 5.

die.

A. Freedman).

aaloxone in heroin Depcndence, C££n. Phanm. Thenap., 9: 568~577.
(with A. Zaks, R. Sharoff, A. Mora, A. Brunet, S. Levi: and A. H.
Freedman).

Clintcal Studies of Cyclazocine in Narcot1c Addiction. AmeA. J.
P3gchiat., 124: 1499~1504. (A. a. Frcedman, #. ﬁ. Sharoff, and
A. Zikl).

V/

�</text>
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                    <text>May

17, 1972

Mr. R. Graﬁwcll

Contracting

folcct

Jotional Institute of

Manual Hoalth
20852
Rockville, Maryland

Dear Mr. Graduall:

Enclosed

is a formal application for the study:

PHYSIOLOGICAL EFFECTS OF CﬂRﬂHIC CANNABIS
USE IN HALE JAHAICANS

The protocol and budgets have been worked out in detail
with Professor Michael Booubrun of Jamaica and the staff of the
HIHE, Division of Narcotics and Drug Abuse.
We

look forward to meeting with you noxt week.

Sincoroly yours,
Fink, H.D.
Profcsoor of Boychiotry

Max

Hing
Enc.

�</text>
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                    <text>ﬂay 15, 1972

Representative Paul Rogers
Representative:

House of

Washington, D.C.
your Sir:
Some

months ago you were kind enough to discuss the national
and invited any progress report-

effort in the narcotic antagonists;

be brought to your attcntion.

Enclosed are some report: I have pulled togathcr in
to the extensive publicity given the Vera Institute proposal response
by the
New York Times, radio and TV mndia.

Sincerely yours,
Max Fink. ﬁ.D.
Professor of Psychiatry

MF:1g

Enc.

�</text>
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                    <text>.vrrw- paw.»-

-.. .

x.

.

~

"w...“

v-

-

w

m’m-rr‘aa’ll¢\mn—w'ru'

".

Arr..»-.—...; .... m

.mwrnv ”.1“.

'I-W

a..- mu—u—rugnwmq...

._

.N .

”we“. , w.“

.

,

..

e

.. w...—

rhuwwnw «we... st

5"”!

May

a“

12, 1972

Robert L. Robinson, Editor

Psychiatric News
1700 18 Street NW

Washington, D.C.
Dear Robbie,

I am pleased to enclose a copy of the special issue of
Seminars in Psychiatry devoted to the newest experiences and theories
about ECT and Indoklon therapy. This issue serves the special purpose
of bringing up-to—date the clinical experiences with unilateral ECT,
multiple ECT, Indoklon Edi; some of the theoretical formulations assisting research to understand this process; and some interesting questions
and answers most frequently asked by students about this unusual form
of therapy.

Perhaps, you would think
reviewed for your readers.
Many

it is

done well enough to be

thanks.
Sincerely yours,

man-um

.
"no“

:
ngn

nwrur-

wm-zvvu

nravmsr-

V’THVV‘I

,,.
m-x

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>May

ll,

1972

Miss Candy Poinior
Colby College

Wotarvillo, Raine
Dear Min:

It

Poinior:

like I will be unable to visit Colby College
this
I am willing to offer you an opportunity to work
in this laboratory as soon a: school is over:
now

looks

month, and so

In

New

York

until

September/October.
a Research

we nova

to Stony Brook in

Technician at $7,200/yoor
in training. plus the usual perquisites of
fringe benefits (Blue Cross. insurance. holidays.
sick leave, etc.) of the College now (and the
comparable at SUNY—Stony Brook in the fall).
As

return .

Enclosed

is

on

(EEG)

application form; comploto what

you can and

I look forward to mooting you.
Sincerely yours.
N.“ Pink, PhD.

Profoloor of Psychiatry

HPxig
ﬁne.

�</text>
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                  <elementText elementTextId="106452">
                    <text>May

Mr.
9

Patrick

11, 1972

Slbonoy

Winter Street

Hatorvillo,

Maine

Door Hr. Sibonoy:

It now looks Ilka I will be unable to visit Colby Collage
this month, and so I am‘villing to offer you an Opportunity to work
in this laboratory as soon as school is over:
In ﬂew York until we move to Stony Brook in
September/October.
a Ronaarch (EEG) Technician at $7,200/year
in training, plus the usual perquisites of
fringe benefits (Blue Cross, insurance, holidays,
sick loave, etc.) of the College now (and the

As

comparable

return.

Enclosed

is

an

at

SUNY-Stony Brook 1n

the

fall).

application form; conploto what

you can and

I look forward to looting you.
Sincoroly yours,

“a
m. ”In.
Protoooor
of

Psychiatry

ﬁrsts
Eat.

�</text>
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                  <elementText elementTextId="106453">
                    <text>Hay 11, 19 72

Representative Paul Rogers
house of Iepreaenrativos

Nashington, D.C.
Dear

Sir:

to discuos the national
invited
any progress reports
effort in the narcotic antagonists;
attention.
(and problems) he brought to your
Enclosed is some material I have pulled together in response
Now
York Times publicity and apparent enthusiasm for heroin
to the
50m: months ago you were kind enough

and

maintenance.

the lites indicate, there may be a small problem in the
supplies of dipronorphine. ‘We have been assured of assistance byShould
saooAP; of intereot by Lederlo; but the facts are at variance.
you wish to assist those researchos, an inquiry from your office may
be productivo.
As

Sincerely yours,
Fink, M.D.
Professor of Faychiatry

Max

ﬁfzig
Enc.

�</text>
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                    <text>May

10, 1972

Dr. David de Wied, ﬂ.D.

University of Utrecht

Vondelann 6

Utrecht, Netherlands
Dear Dr. do ﬂied,

June.

My

I look forward to your visit to
present plans for that period allow
We

New York
me to be

at the
in

New

end of
York.

are presently in a study of 01-63 and the data collection
It will be most interesting to discuss

should be well along by then.
the work and the background.

Please write to

Irrive in the city
in the evening, at

me

for a specific date. Should you
at 212—369 8488; or

you may reach me in New York
my home, 516 466 5444.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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