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                    <text>gs—v—r-w m—vm

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-

January 28, 1988
Mrs. Edward M. Bigler
#0 Doubling Road
Greenwich, CT 06380

Dear Mrs. Bigler,
Thank you for your request that I participate in the Phil Donahue show.
Beginning with the appearance of the New Yorker article by Berton Rouche
"As Empty as Eve' in 1974, and my subsequent work with the APA Task Force on

Electroconvulsive Therapy, 1 have actively assessed the merits and limitations of
the ECT process. What may have been a debate in the 19703, as to the merits of
the treatment, has been resolved by the many assessments by individuals and
international commissions and committees, culminating in the 1985 NIH Consensus
Conference. The question of ECT efficacy is resolved. Until a more effective and
safer treatment for the serious mentally ill is devised and tested, ECT remains a
useful and needed treatment. That is not a matter of public debate, either by the
Phil Donahues or the Opreh Winfreys of the entertainment world.
Indeed, the acceptance by laymen that there is a 'debate‘ on efficacy and
into the hands of the anti-psychiatry lobby. There is no more reason
plays
safety
for a debate by the laity on TV or radio of the merits of ECT than it would be
reasonable for a debate on the merits of insulin in diabetes or penicillin in
neurosyphilis or any other technical medical therapy.

In the face of the anti-psychiatry lobby, there is a need for public
education, but in proper fora. For that reason, my associates and I were responsive
to the requests by Susan Squire for an opportunity to meet treated patients before
she wrote the November 22, 1987 article in the New York Times Magazine; and
why we have been cooperative with the PBS/BBC producers of the series MIND, to
appear later this year.
We continue to seek to improve the delivery of mental health services, and
my present missions support this aim for ECT. I wrote my review of ECT in 1979,
launched the journal CONVULSIVE THERAPY in 1985, and have developed a
training program in ECT at SUNY at Stony Brook in the past year.

But I will not cooperate with a 'show', surely not one of the kind produced

by Phil Donahue under the guise of a 'debate‘ or a 'balanced‘ presentation. But if I
can help you present the facts of EC‘I‘ history and present practice in educational

venues, please call on me. I enclose articles that may be of interest, as well as a
description of CONVULSIVE THERAPY.
Sincerely yours,

cc: Donald Klein, M.D.

Max Fink, M.D.

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                    <text>January 6, 1992
Mrs. Renee Bigler
Doubling Road
Greenwich, CT 06830

4O

Dear Mrs. Bigler,
have searched my collection of videotapes and cannot find one of
the Phil Donahue interview to which you refer. Since your letter asks that it be
returned, it is probable that did so at the time.
l

I

I

appreciate the problems with your son. Looking back at our

experience since 1987, do believe that we have confirmed the observation first
reported by Meduna in 1937, that patients who have been seriously and
continuously ill for more than two years achieve little persistent benefit from
ECT. We treat only one such patient, mainly because without ECT he becomes
aggressive and hostile, and with it is more relaxed and cooperative. His family
insists that we continue, even though he remains in a protected environment.
I

It

is probable that the hope of an important effect from ECT for your

son is misplaced.

Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

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                    <text>August 22 , 1967
Mr. Alan Billig
E'Loffmarm-La Roche

Inc.
lﬁngsland
Nutley, New Jersey 07110
3H0

Dear Mr.

Billig:

Thank you very much for your willingness to support our
study program. As I had mentimed to you in my office, we have
been using Libriwn for the past four months in the psychophannacology

study program in the Mental Health Clinic as a stardard in the treat-—
anxiety. We would be grateful to receive 5,000 capsules of

ment of

Libriwn, 25

mg

eadl.

We'have been treatimg cases of anxiety in the clinic and
fave used Libriwn as one of the standard medications. I believe
that this is the best way t9 train our resident physicians in
the proper treatment of the acute mentally ill.
Thank you very much

for your assistance in this program.
Sincerely yams ,

'

Fink, 91.1“).
Prufeesor of Psychia

Max

V

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                <name>Text</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="101196">
                    <text>January 8 ,

R.

Simmer,

M.

196%

D.

Medical Director
Sandoz

Wutioals
Jersey

Hanover,

New

Dear Dr. Birdwr:

olinicaland
Ithas takanm ayeartoeotablishthe
now we are progressing

laboratory facilities of our Dmtituto. but

125me mm

in our
prom.
I am writing to request yam? mommim in obtaining
supplies of LSD-25 in «3mm sufficient for two stﬂos. In one,
, wwld
Dr. Sam Gemhm, Principal Reward: Scientist
and
oomlike to comm the antamxism of«-131) to craorpmmuine.
In
this
affect with tho Ditran ohloxpmzine pattern.
pm this
of blocking agenm
study, he is continuing his assessment of a variety
and EEG,
olinioal
both
The
has
study
to andoholimrgic

very nicely

(Why)

aspects.

Woo.

interested in the effects of
Sm yous ago, I boom
various drugs on olootmmphioal slow wave activity. Dr. Tumn
who is on the staff of the Institute as Principal Research
Itil,
Scientist (EEG) , has makemd that intemt by his observations
dependent on
of the effects of LSD on EEG panama whim is higxly
We
would
like to
the initial state of the alootmnoephalmm.‘

reassess this relationship.
From am of the Wardens which Dr. Ulott, mmctor
to m, I am more that
of the Divioim of Mantel Diseases, has sent
LSD.
The control of the
of
distribution
tho
in
there are pmme

�Bimhar, H. D.
Jammy 8, 196%

R.

Pam The

distribution and we of LSD in the mssouri Institute of Psychiatry
is vested in my office, and fw this mason I am waiting dimctly
to you. I would appmciate your ooopemtim in providing us with
about

30Wefﬁb,iftheymstillmdaupin100 gm

quantities.
year.

Dr. Ulett joins m

in wishing you the best for this
Sinmmly yours ,
fink,
Director
Max

Wsmlg

M.

D.

�</text>
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                  <elementText elementTextId="101217">
                    <text>January 21, 196k

R.

Hitcher.

Meal

M.

D.

mmctor

Dear Dr. Bimher:
by NIH!

'me

investigatim with

pmjectsz

LSD

am suppmmed in part
'

- EEG and Human Paydxophammology

m

072%

Md

08517 .. Thampy
New

I haw also

Resistant Psychosis and

W

askad Dr. George A.

mutt, Director of
to

mm.

the Division of Mental Dims of the State of
send you a note regarding his appmval of this pmject.
Sincerely yours .
Max

Fink,

Dimmer

MFxmlg

Em.

2

M.

D.

�</text>
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                    <text>January

30 , 196%

Birdxer, M. D.
”adieu Director

R.

Sandaz

Manuals
Jamey

Harmer,

New

Dear Rudy:

has been received. Many thanks.
Wewiubeginmeatwﬂieswithinthemxtfewweeks, andwill
10d: forward to making some contribution to the litemtum.
The supply

When

of

LSD-25

next you'am

have you stop by and

inSt. taxis, wewillbe pleased to

visit eur

new

labomtcrias.

Simly yours ,
Max

Pink,

Director

H. D.
,

�</text>
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                  <elementText elementTextId="101482">
                    <text>MI}

3,

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“utabnahtag a clinical and alaetroencaphamgraphic away of the
tantalum-tan of thiorldnim with ahlordtnamxtda in schizophnnic
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put far maths, at. Matt

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ﬂak. 3.3.
M
Btu-ate:

III/1|:

m: M.

Blunt:

9:. let!

�</text>
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                    <text>Ely 21. 1964

Dr. R. Birohor
Hodtool Dirlctor
Sondox Phornoeouttoolo
Honov31. ﬂow Jorooy
Door Rudy:

th
this instituto, I rosrot tho: V! have

In roply to your

lotto: of

7, ooocotning the no. of
no onto :ooordn

LSD ot
for the

ported Juno 7. 1963 to January 7, 1966. Indood, "I have just
boson our studio. with L33 during tho past ton dayo. In this.
on or. odolniotoriu; L8H to psychiatric patients in our BEG
laboratory to ﬂotation. tho rolstion botvocn changes in EEG

pottoro
Boob

quoot

and bohovlor.

iniornoeton will ho nods Ivoiloblo to you upon your to-

at

noun

future date.

Sincerely yours,
Kn:

rink,

Director

HIV/1b

H.D.

�</text>
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                    <text>June 1, 1966
Dr. R. Birchor
Hodical Director
Sando: Phatmacouticals
Hanover, New Jorsey
Dear Rudy:
Enclosed is a copy of tho abstract odbmitted by George Ulett
to the 018?. The dots for this study is that material cokﬁ

looted by him two yoars ago and presented, in part, at various
It is our intention to summarize both his
experiences, those of Dr. Itil, and my own with regard to tho
EEG effects of combined drugs.

nesting: since.

With regard to the mothod of administration of these compounds,
I do not beliovo we intended to mix the compounds. It is our

policy to give medication to patients in liquid vehicle, and,
they are accustomed to roceiving ona or two liquids two to
thtoe times a day. Since we will be giving two known compounds
and administering thom soparatoly, I do not believe that an IHD
would be necessary. I hopc this is a feasible resolutiou.
Thank you

for your consideration.
Sincerely yours,
Max

Fink,

Director

Hrljb
3m: 0

M. D.

�</text>
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                    <text>.—

.

Jana 17.

\
N,

an",

1966

U‘y

A

Dr. R. Bircher
Mhdiccl Dircctor
Sacco: Pharmaccutlcals

ﬂancvcr.

Haw

Jersey

Dcar Randi:

for both of your recent letters and for your many excellent
con-cuts conccrning our cachiacd drag study. We arc indeed grateful
for your Consideration of our rcquast for grant funds. The funds in
lupport of the research studies at the Missouri Institute of Psychiatry
are handled by the Psychiatric Rcacarch Foundation of Missouri and we
would be grateful if you would concidcr making any contributions in tho
nan. of the Psychiatric Research Foundation and would ask that your
lattcr of transmittal be phrased in a form similar to tho proposed
Thank you

draft cttachcd.

We

are

now

in communication with the manufacturers of chlordiachoxide

and as noon :3 crranacncnta can be made with them. I should like to work
out a suitable proparntion.of concentrate and matching placebo.

I

.

an act planning to be at the AHA nor will I be in Now York until late
in July. ﬁcwcvcr, if you are going to San Francisco I would be most
grateful if you would stop off enroutc, either before or after.the mootinns, and arrange to meet with Dr. 1:11 and mynelf so that we can discuss
this program in greater detail._
»In tho mounting, we have recently begun our studies with LSD and the
supply which you provided some months ago will soon be exhausted.
Dr. 1:11 18 unccuring the tolerance of our patients to increasing dosages
of LSD, and considering that he is doing two to four trials each week,
I would bc gratcfnl for an additional supply. Would it be possible for
you to send an an additional 100 ampoulca?
Thank you

for your cooparction.
Sincerely yours,
Pink,
Director

Max
M3115

M.

D.

�is pleased to

The

approve your request for a grant in aid in the sum

of s

for the general corporate purposes of

the Paychintric Research Foundation of Missouri.
or:

...£or tho toaoaxch

and

training programs of tho

Psychiatric Rosearch Foundation of Missouri.

�</text>
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                    <text>June 11!, 1965

m.

R.

Bimher

mum
3m:
Hmmr. Now Jemcy
Hndioal

Wale

Dear hwy:
on

Pint htmthamcyoufortheinfomatimyousentm
Yam"
latter was helpful

LSD.

and salty

this aftemom did
which I will

I maniw the pacing: of photocopied articles
and this wank.

your

W
I

towritetoyoumgaming
ammopportmity
12411;. liming the past few mums we have been

Wt

mined drug
program and special
studies with butnpomim and triﬂuperidol. Hy associates mad
I have
a variety of
including the informa-

pmoocmpiod with our

lama

W

tien you 3%“:th regarding SAW—1123 and T9843. We am more
interested in IZ—Slu and would appmciam any additional inform»
tim vanish you may now have available mgaming studies with this
wand. Specifically can you all us who else is studying this

WMinwhatkindafpopulaﬂm?
Many

'

thanks .
Sincerely
Max

Pink,

yam ,
PM).

meessor of Psychiatry

�</text>
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                    <text>member 21.

1965

Dr. R. Bimhw

Wale

nineteeMeal
Sandon
Hammer,

New

Jersey

MM,

Inmthetlmwubletonttwdthemﬁngein

mmmIdywmmmmmlym
mined mmmm-mmmaa stuck.
mmimlmlmmmnelmgandwemhegmmg
Puertoﬁioo.
the date of mm

Aehmyhmmtimadtoym,ﬁn
mmmm.
Whtahugimmmm. '11»me
bemtmtiedaminhemglcbinmdhmomtinthe

mam.-

dimotim of a distinct fell marina thioridezine
and again when thiamiduim is webbed with

ticn,

dzlordimpmdxle. Tomﬁmthimwemnwmviowimtm
obsewrtime with other phmthiazinee and with our placebo

Munitions.
mummofintemst,thisabemaﬁmdoeemt
aemdt w mmtindings in‘anmberof subjects;
the hospital internist has NW changes in the m; dam
ﬁxioziduine aministmtim interpreted as indicative of
”bdee bmeh block.“ In four of our eubjeeta we have withm
alludieetimmdmmmommdingbimkly‘m. As soon
mm,wewouldlikctohave all
eswehmthmemmive
records) taken dining ﬂan
(epprmcimetely
the

mus
m

reviewed by an eutaide

agreeable, uwld you like to
in this analysis?
My

W

atwy
a ooneultmt and participate

multamz. If this suggestim is

best regent and Beet

Wishes

for a prosperous

New

85:16:!er yours ,
Mex

Pink.

15.1).

Professor of Psychiatry

cc:

Dr.

Itil

Year.

�</text>
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                    <text>September 21,\1964

Birch‘r. MOD
Mbdleal Director
Rudy

0

Sande: Pharmaceuticals
Hanovot. ﬂew Jersey

Dear Rudy:
Thank you for your lotter of September 14th. I look forward to
meeting Dr. House on the 23rd, or the 24th of Soptomber. I believe
that George Ulott will be in out-scata Missouri during those days, and
Dr. Itil is on his holidays in Europo. However. the rent of my staff
are here and we will be pleased to show Dr. Benz; our program and the
plans VB havn for our collaboratlvo studies.

I will be at

homo that evening, (Mission 5—4579) and will be pleased
to moat with him, either at home or in the city.

I look forward to hearing from Dr. Hanna and
has. an opportunity to visit with us soon.

hope

Sinceroly yourn.
Max

213k. M.D.

Director

will.

that you, also. will

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                    <text>thy

25 , 1966

Dr. Emily Birchex‘
Sande: Laboratories

Hammer, New

Jersey

Dear Rudy:

As'ymhm,mhawbmdatmningﬂnﬂnusholdto

lSDlnmrschizoptmiopatisntsusingEEGmdlmgmge with
mamsaseriteria forﬂnmbmapmmc. Wemfwad
mmessityofobtainingacmpariamgxwp, anditwas
suggested that

we

mdertake trials of

13D

in volunteers.

for
mliar studics we have givm LSD to volmteevs We
asinghaMnismtimindoaesupto2mperkg.
of LSD in
are new mtieipating the repeated
doses varyingfmeJStoLﬁ mmkg, atmkly
In

Wtim

intervals for an avenge of six ammtima.

Imﬂdbegratefulforanyinfmﬁmwlﬁchymmy

haw available: mgrding the repeated administration of LSD
inmlwhmtuminthisdosagemgemdatmtesas
fmqmnt as one achinistmtion a weak or every ten days.
Specifically, our research mittee is intematad in
4:1:

Uthomisanyovidmeemgamingtmmhp—

mt
ofﬁddictimtoamhwhﬁmﬁmormemimof
payouts
.

Ir. H. 143mm visited us last week and presented his
fixﬂingstowmeamhgmup. 3111.311):wameticn fwuemjoyed

itmm.

'

Sinceraly yours.
Max

Fink,

M.

D.

meesaw of Psychiatry

�</text>
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                    <text>Jme 22,

Dr.

J.

1968

Bird

Director, Clinical Peasant:
Starling iﬂnthmp Raaoamh Institute
Ranaanlaar,

Haw

York

DaarDr. Bird:

mmstudiaaofcyclamixtam,uyat,inmlateand

ImmtimdngthuinmtigatiauinﬂewYm'k. Ihavnahippad

ﬂamingcyclammmuawmﬂcmitismmmnait.
Ratmﬁmnmﬂtisawply,lmﬂcmtymcmpymm
mmindicntaﬂntmamsndyiuminuingatﬂn
Nat: York helical Collap
Phtropolim Hoapital Cum. ma
tillhauaduavailabloatﬁnmlmimofﬂnstwy
thanmdllmiuamobamatima

mmmmdafiniuwinmimtothe
mlchmofpaycmmpicmmyactiwdm,
mfficiuﬂymiqmmmtmming Aacomulhava
mammamiu,ltdllbaplaaudmmyouaoopy.
Itmatwaom‘cmtimnthiaatndyinmismlocatim.
Sincerely

yam ,

.

Fink, M.D.
Professor of Psychiatry

Max“

mfvwv‘n:

,...

.‘

warn-r."

nw:mvrv

"a

HF:kp

�</text>
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Dr. Joseph Bird
Staling—Wintlmap Research

Rensselaer,

New

York 1211“;

Institute

Dearth Bird:
Enclosed

I trust

My

it is

is the statement of irwestigator‘ you requested.

satisfactory.

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Ifzkp

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                    <text>January 10 , 1967
Dr. Joseph Bird

Sterling-Wintm'op Research Institute
Renaeelaer, New York
Dear Joe,
Enclosed are draft copies of the reports of the
secondary effects of cyclazocine and our EEG sumary.
The secondary effects data has not been submitted for

publicatim; theEEBmaybepubliabedbytheAmrican
College of Nempsyohophamaoology.
Thenk‘you for your

'

interest.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max
MF:kp

.

,

�</text>
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                    <text>J1me
Db. Joseph Bird

-‘

New

York 12141}

1967

7

t

Sterling-Wintm Research Institute

Renaeelaer,

29,

»

-

Dear Joe,

Wise

Sepamtely I am wading; you the
of the active
inactive owes" of the cycle’zocine trials fm 8~—1~66 to
3~31~67 at Metropolitan Hospital. There is little additional
infanmtion available. I hope that these are useful
the records
I have arranged .ﬂmt these were "owned?
by two resident physicians end agreed to
them at
and

‘

m
mate
review took 60m.

,_

_

$5.00 an how. The

-

-

It would be met

helpful

if we

eould wnpeﬁsate these
mule? ask that Sterling»;

wen

for this reason I
indirectly
Winthrop make available ’a sum of $300.00; to Psychopharmeology
Services, Inc; and seem to we at the New York Medical College.
This consulting; fim will ”in turn compensate the residents.
I look forward to seeing you next mmday. My best
and

‘

mgams.

,

.L

'

’
.

Simly yom ,
Fink ,
t
m
Professor of Pathiatr-y
‘

.

:51”sz
-

:‘
.

‘
:—

A-vrmrr"

my

—~

-&gt;

"um-Wyn

-'

mummw-f-r'

;

MuD

l

'

�</text>
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                    <text>June 27 , 1957
Dr. Joseph» Bird

h

'

.Sterlingmintrmap Research
Reneeelaer, New Yark 1.21M

Inetimte

..

Deer Joe ,
1

I

should like ta report on my reeent presentation of
the
cyclazocine—depreseim data to the ECDEU investigators in
Montreal. The mter’ial was presented at e
on enti~
depressant drugs and me than 30 investigating team were

mime

‘

represented.

.
.

CW

Since the only other optimistic name were
about
a report fmn Perle *on chloxﬁmiprenine and referencee jto
mltiple EC}: (Blachly g3; all, University of Oregon), mch
interest was
The. beet mggeetion was male
mm
by Dr]. Cole who indicated a7 willingness 1:0 use cyclamcine

em

,

_

:

mm.

in the present NDIH depmasim etudy program Eight mspitale
are studying standard entidepeeeeent drugs and cycle-moire
may be 'intmduced in the mement failures. The study is

,Lcentrolled by Dr. Raskin of the Peycmphmaacolqw Study

?

"Bremh, NW. The units most likely to be interested are
Dr. Cole/DiMaecio at Boston State; and Dr. Tyce at Rochester
(Mirme'ota) State. But Dr. Reskin indicated a willingness
to
call a meeting of the investigators later this summer am the
‘invee‘tigatere weld be pelled.
.

a

.

-.

Othfn"

j

units which expressed an interest and dealt! test}
are:

~"musicalememe

,

Dre. H. Let-mm and Bay,
Dr. A. Kmrland, ﬂexing

Manual.

Ii

'

-

We State Hospital,

Dr. Dmmld

next

ﬂesh, Hillside Hespital

'

,

I mum be pleeeed to ﬁlms; the text ates-e1: our visit

May.

.

'3le we

,

Fink, 14.9.5:
Professor of Psyclﬁatxy

Max

MF:kp

,

�</text>
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                    <text>.
-

,
v
A.

..,,

-

v—ww...

.A

uN‘WMWq-‘Krww-t‘vvr—‘w

raw—ran

um.

June 20 , 1967
Dr. Joseph Bird

Sterling-Winﬂmap Research Institute

Remsslssr,

New

York 1211“;

Dew Joe,

Emlosed are

some

copies of shipment notes for your

files.

Dr. Simon has requested an additional supply of cyclszocine
tablets, 0.26 11g, 50 battles x 50 tablets each. The meant
supply will be exhausted by mid-«July.

Sirmmly yours ,
Max

Pink,

PM).

messsor of Psychiatry

�</text>
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                    <text>May 3 ,

Dr. Joseph Bird
Sterling—WinthrOp Research
Rensselaer, New York 1213a
Dear

Joe,

that

we

It was nice having

you

1967

Institute

visit. I regret that the date

picked,
to be unsatisfactory for
would
be grateful if you would
our visit to Rensselaer. I
and
me
time.
we
another
call
can set
WIN

May

Would you

20,7“0, .25

22, turns out

bottles of
tablets per bottle) for the

kindly arrange to send
mg (50

me #0

continuation of our antidepressant study.
Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July

25 , 1967

Dr. Joseph Bird

Sterling-Winthrop Research Institute
Rensselaor, New York 12144

Dear Joe,

is a

letters written to
the collaborative investigators in the proposed cyclazocine~
depression project, explaining our present status.
I am also enclosing ten additional reports of patients
treated with cyolazocinn in the narcotic study program.
These are the patients who have been treated most recently
and were still on the ward at the time the original summaries
were contracted. 'Please add these to your collection.
Enclosed

call

carbon of one of the

With regard to the depression study, perhaps you would
on me in late August so that we can make the necessary

arrangements.
my

best wishes for pleasant fishing.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>:q-u

:r
rm

‘ef'oa‘ﬁ-"n‘

July 17,
Dr. Joseph Bird
Sterling—Winthep Reeeerdu
Rmsselear, New York 121%

1967

Institute

Dew Joe,
Enclosed are copies of the letters from Dr. Allen Raskin
of the Psycmphamecologr Research Branch as sent to the
preject coordinators of the MIME depression study. As we
diemseed I will call each of the projact coordinators and
attempt to set up a mating to develop a collaborative

cyclezocine study.

In additim to these irweetigetors , the other invitees

should include Dr. Cole,
and Zeke

I will

speak

to

you:

Ir. Itil

end from

at the end of the

my

staff,

Dre. Simeon

week.

Sincerely yours ,
Mex

Fink,

PM).

meeseor of Psychiatry

7

1'4?sz

�</text>
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                    <text>July 1a,

1957

Dr. Joseph Bird

Research Institute
Mm
York
Ransom,

Starling

New

121m;

Dear Joe,
At Dr. Itil's request, I am enclosing the case smuaries
eleven depressive: treated with cyclazocine in Missouri.
the
for
These will ocmplate your files for that atmiy to date.

Sincerely yours ,
Mal Fink, M.D.

Mszp
cc: Dr.

Itil

�</text>
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                    <text>Febnmy

2%,

1966

Dr. Joseph 6. Bird
Dixootor, Division of Clinical Research

Sterling-Hinthop Howrah Institute
Division of Sterling Drug Inc .

A

Rensmlaer,

New

York 121:“;

DeerDr. Bird:

I

I’D-1572

pleased to enclose t}: ﬁatemnt of Investigator Form
regarding the study of the EEG effects of cyolazocine.

am

Ihavereedthetmbroommsmﬁmywhave mmmittedsndyow
letter with great interest.

The reaction of typemyndu'ony which is described in the
sectim related to oats would permit the olemifioatim of this
as e narcotic or native. 'me bdxevioml observations ,
twwever, indicating a 5% development of Mllucdnetims would
suggest that saw subjects do develop a desynchrmized pattern
at the mug-s given.
We mold like to take advantage of the opportmities
presented by these laboratories to determim the EEG spectrun
of activity in sane of the psydwtic subjects and possibly a

amber of volmteer-s.

Sinoemmdosageswillprobablybelesstmnlmg,m

wouldeppmcieteesupplyofmpulesoflmm .Smgpotenw.
Adozenmulesofeadawouldbeanedequetesupply.

Wewouldbedelig):tedtohavsyouvisitmin8t.louiscn
mofyoxmtrips. Pertmpeweshouldestablishedosagesohedule
and EEG
effects of
oyouzocixnmdthensendmisinfomtimtoyou. Iwouldagme
ﬁxatettlmttim, evisit mightbewtuelly helpful.
‘ihmk you for yam assistance.

which domatrwtes some

of the behavioral

Sincerely yours ,
Pink, Md).
Professor of Psydxietry

Mex

�</text>
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                  <elementText elementTextId="105253">
                    <text>‘p‘i’nhV

-m-m

-:

wm’r—

:
m.

'zv—In

"‘s—rwz-z-

r

octobsr 4,

1966‘

6. Bird

Dr. Jossph

Director. Division of Clinical Rssssrdh
sterling-Winthrop Rosoarch Instituts

nonssslssr.
Dos: 3b..

Row York

Enclossd is a propossd protocol for tho
study of cyclazocino in depressive disordsrs.
I would be grateful for your connsnts haters
tho proposal is otticislly submittsd and
approvsd.

srs beginning a now rotation
opportuns tins to initiats this

As ws

of rssidsnts in tho usntsl Hygions Clinic.

this is

an

prOposal.

I will hs away until
you early nsxt weak.
Many

Monday.

so will

csll

thanks.

sinosrsly yours.

as:
rink ‘H.D.
o: Psydhistry
Protsssor
l33kp

.é‘.

�</text>
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                    <text>December 16, 1966

Dr. Joseph 8. Bird

Director, Division of Clinical Research

Sterling—Him

Ransselaer,

New

Research

York

Institute

Dear Joe,

B'xclosedisadraftcopyofmmmpm'tontmmseffects
ofcycluocine, aspmsentedinthammetingsinﬁmollmo
mﬁerﬂmianonth. ﬂayhavemquasted pemiseiontopublish

ﬂﬁspmlimimymportasputofﬂnirmceedings.

May

I

Iwouldlﬂcetocite-tlwmnm(seemfmsland2).
have the permission of Sterling-Hm to do so?
Pleasedonotslmﬂxisccpywithanymeasitisa

draft. Assocnastrafinalcopyisprepamd

.withinthe.mxtfewweeks,1willsendonetomfortm
useofSterling—Wintm.
My best regards for the

New

Your.

Simely yams ,
that Fink, PM).

Manor of Psychiatry

'

HF:kp

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                    <text>January 18 , 1967
Dr. Joseph G. Bird
Sterling-Winthrop Research Institute
Rensselaer, New York

_

Dear Joe,
The study of cyclezocine as an anti-depressant in the
Wmtal Hygiene Clinic has begun. The initial patients are
now receiving :Imipmmine and will shortly (about February 6)

begin active cyclezocine treatment.

,

The supply of cyclazocine which was shipped on October- 26,
contains l£00 tablets of .25 mg. We will Mgin with this supply
but I anwriting toaskthat youmake available an edditioml
supply of . 25 mg cyclazocine and equivalent placebos. I would
ask 1,000 tablets of each to start.
My

St. Louis friends have sent

study and it is most heartening.
study wrist way.“

I

me

am

another report on their
very anxious to get this
‘

}

Sincerely yours ,
Fink, 14.13;
Professor of Psychiatry

Max

Mfzkp

�</text>
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                    <text>_.

.
.

r
a

-

A»

:

:
was,

r

Dow 22, 1966

«2.;

«u-

wow.

Dr. Joseph a. Bird
Sterling~WintMup munch

var-9

any

which:

Rancher,

games;

1"!

New

York

Institute

Dear Joe,

_

Itwasvezykixﬂofyoutormanbermatthistm.

k5137'zW-1'J-‘Vw'mm.

7

childmnhavealmysenjayedopeningpackagesdelook

fmtotakmgthisranetonightmdmmiamgﬁm.
Sincerely yams,

r'

.-~m:'»":,:r

Amx'nzrlzl‘wln

Max

'1)“.

A

ryr-r-W

Frugal.

lynx“:

zf14.".j‘:,l

_-

)4
‘1'.’

LA'I’v_-4ﬂ...‘i"l‘."'

:v
x.
.v

1-1.»!

..

2w"

eg
351-.—

_

I77

Fink,

M.D.

Professor of Psychiatry

W.‘(:.:‘Mnyy{/.V

Wzkp

My

�</text>
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                    <text>April
Dr. Joseph

(3.

17 , 1967

Bird

Director, Division of Clinical Research
Sterling-Wintln'oo Research Inttitute

Rmselm,

New

York

Dew Joe,
Both Dr. Freedman and I were pleased with your letter of
April 12. The anti-depressant study of cyclazocine has been
going quite well. Nine patients are already in the study and
three of these are receiving cyclazocine. Each has tolerated
the treatment and we are waged to continue the study.
The supplies of cyclazocine
were shipped from St. buis to

NewYorkandweamnwusingthan.

Dr. Madman was delighted with your imitation to present
a seminar in Rensselaer, for, as you knovz he frequently visits
thempitalmwrmhehasfamily.
PerMpsymmuldcam
to arrange such a visit after the American Psychiatric Association

meetings .

Imldbepleased to haveyouvisitanytimsdnringtl'e

wafewmoksexceptAprilZIandMayS.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MP:kp

cc: Dr. Madman

�</text>
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~mxmnm-

August 22 , 1957
Dr. Joseph G. Bird

Director, Division of Clinical Research
Sterling-Winthrop Research Institute

Ramselaer,

New

York 121M

Dear Joe,
The study of cyclazocine in the Mental Health Clinic has
been going very well and I am writing to request an additional
supply of cyhlazocim. Wand you please send 200 bottles of
cyclazocine 0.25 mgm (50 tablets per bottle).
Tharﬁc you

very mch.
Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

Mftkp

,

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                    <text>.mp1..-: my“ .‘~ .~._

_.... w-v-xr

. . ~

.

-...

mama

Mmmmwvmun—wn

-

.

-

v

7~m~vmwr&gt;wn .,

,

wmw Vrlr" *-'.¢'&lt;-m—u.v

m».»

..- new mm (at--

n‘ 51'-)‘qt

”mp,” ”tum-47., “an.“ ,5...wwumw-n-rrum-murm-w

October 26, 1987

Dr. Joseph G. Bird

.

Director, Division of Clinical Research
Sterling-Winthrop Research Institute
Reneeelaer,

4

New Yowk 3.2144

'

"WV—n...

Dear Joe,
Iwu—Tv'r'mvu-

I have spoken to Dr. T. P. 8. Watts of Geigy Phannaceuticrals
and he beliewes there should be no problem in obtaining the
for this study. I spoke to him on Howey after his
511de
from
return
a trip and he believes he can give us definite informetion early next week.

.K‘W

mm...

wr(wv-vvy¢

Because the dosage Scledule
is defined I have asked Dr. Simeon and Dr. Zeke to begin the next
few patients on this new schedule withwt going though prior
imipmzmne tmam'ent.
The

revised protocol is enclosed.

'

‘

.

the time that we haw the supplies, we should have had
experience with this new dosage scledule .
to suggest payment for the expenses of our
It is kind of youncminal
and can be defrayed from the funds
trip, but these were
we lave already zeceived.
By

.

As part of this new protocol, you will note that we have
decided to use the Hamilton Rating; Scale. This scale has the
advantage of widespread use and has been adopted by NEW for
the early clinical program We lave asked Dr. Shapiro, our
omxputer director, to develop a special diagnostic program
and this should be available in time to be mienented in the
cyclezocinenimipmmine study.
My

best regards.
Sincerely youre ,
Pink, Mi).
Professor of Psychiatry"

Max

{‘1sz

v

m...

.—

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                    <text>October 4, l§67
Dr. Joseph 6. Bird

Director, Division of Clinical Research

Sterling~winthrop Research Institute
Rensselaer, New York l2l44
Dear Joe.

Enclosed

institutions.

is

a proposed protocol

for the collaborating

In addition, the modification of our protocol is also
enclosed and I would be grateful for any criticism that you

have before I implement this. If the protocol is
agreeable to you, would you be able to supply us with

may

cyclazocine capsules with .25 mg cyclozocine in a pink
capsule as enclosed. I can obtain the imipramine from
Geigy directly. If this is not satisfactory, would you
be willing to obtain imipramine from Geigy and make up
matching capsules of 25 mg imipramine and .25 mg cyclazocine.
Sincerely yours,
Fink, M.D,
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>September

l,

l967

Dr. Joseph 6. Bird

Director, Division of Clinical Research
Sterling~winthrop Research Institute
Rensselaer. New York l2144
Dear Joe,

of the investigators you might consider
for the callaborative cyclazocine study. Dr. Allen Raskin can
be reached at (30l) 495¢l393. Dr. Itil can be reached at (314)
Enclosed

M1

5—6230

is

a copy

Ext. 618.

I would

like thlt

Dr. Jovan Simeon and Arthur Zaks from

this department also be invited to the meeting, since they
have been active in the cyclazocine study. While both are
away. I will speak for them and believe that they will be
available at any time after Septemher 22.
Sincerely yours,

Fihk, M.B.
Professor of Psychiatry

Max

MF:kp

enc.
3::
my

¢'

-.-v-.-::\

34;?er

:‘f"W—‘12'\r"‘7‘fw‘}'1fir

my.

law

'-.-‘

twain-1.x

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mm

17-75];

,

�</text>
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                    <text>_

movember 14, 1967

.o\‘—-—w.-.~1_.~..v..-.4,

‘

".

”

;,X Dr. Joseph 6. Bird.

-Director of £xperimﬂntal Medicine
Sterling«w1nthrap Research Institute
RensseIaer, New York 12144

‘

r~muw_yrw-¢-I&lt;-v~v&lt;ﬂ-

'

‘

Ifﬂear Joe,ﬁ

m.

'

Thank you very much-for

A

open study of

cyclazctine as

the grant~in~aid in'sunport of the
antidepressant. We are,~indeed

an

”grateful for your-continued support.of this study program.

just compTeted an additional raport concerning the
background for the recommanéation of cyciazocine as an
antidepressant. This report #111 be presented at the forth«
coming meeting of the ACRP in Puerto Rico. éEncIosed is a copy
I have

EEG

for your informatian.l

'

‘

‘

3

,

It was a great pleasure to have Drs. Rosenberg and warsha11
visit with us on Friday“ I trust that they will share with yea
.

some of our

recent experiences with naioknne. Dr. ﬁarshaI]
indicated that he wou1d like to.discuss a study.of oxypertine,
and I look forward.to meeting with him next Monday.
»

Again, our thanks.
SiﬁCerely yours,
Max

Fink,

M,D.

Professer of Psychiatry

'

MF:kp

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                    <text>mm «vs Hw wwwummmwuwwawww"':~‘l-

‘vin' my van-,|-:-*-n--n1-w.w m«m.vg...; 's’usﬂm-memw

w ‘m‘n-‘mw'nvm

www.mwrx-ruvm-mr

W'vv

um nurwmuwm‘mﬁﬁ

ﬁovember 8, 1967
Dr. Joseph G. Bird

Sterling Hinthrop Research Institute

Reasselaor,

New York

12144

Dear Joe,
We are continuing the present cyciazocine ~ depression
study and are in need of additionai supplies of cyc1azoc1ne
placebo. Would it be possible to provide us with an additional
ton bottles of placebo (50 tablets per bottle)?

Many

thanks!

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

‘

I'ern-rr-w'rew

I.

"Maw

arm-Wu

W'mm'mwrﬁmm

7

mmrv-xﬁs'v

‘
_

MF:kp

.u-wv

'v

w rum

--

arr,

sv‘u w

'F‘s‘“

�</text>
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~

‘

M

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‘W W

..

M"

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»

~m..“mmmmme—VWW.mvmwmwmm.wmmwm mwmmw

{I}

November

2,

1967

Dr. Joseph 6. Bird

Director, Division of Clinical Research
Steriing~winthrop Research Institute
Rensseiaer, new York 12144
Sear Joe,

of a

this

As yau know, we have carried out some preiiminary studies
new narcotic antagonist, naioxone. The EEG patterns of

compound

are different frcm cyciazocine.

data is quite similar however.

The

clinical

you or any of your associates are interested in
attending, I wouid be pleased to see you at the meeting..

If

q
My

best regards.
Sincerely yours,
Max

Fink.

M.D.

Prcfessor of Psychiatry

Hszp

“Vim“...“w‘”

�</text>
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                    <text>_‘m.,.:,,..‘.. .u, u...,.

.- ,

.

v...»

, .
-m. 7.2
m“u. «muwv-‘Tsklv'llvzr$~,&lt;w-:K,xr
~

,

,
-.,.
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-

,

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.«

I»

7,

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.
v“. yr“:
«WV-«m.&lt;- ,wn,‘ "v.“m-.-y.-v-mvmn,
“7. (4r"".
-.|
_

v

.

December-29, 1967
Dr. Joseph G. Bird

Ster1ing~winthrop Research
Rensse1aer, New York 12144

Institute

Dear Joe,
As I have written, we
are now comp1eting the co11ection
6f data in the Open cyc1azocine study.
However, there are a
number of patients who wi11 continue on cyc1azocine
the
next two months and I need a sma11 additiona1 supp1y during
of

cyc1azocine p1acebo and active. Wou1d you be kind enough
to send us 1,000 - 0.25 mg cyc1azocine p1acebo.and an equa1
amount of active cyc1azocine?
My

best regards.
Sincere1y yours,‘
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

“Ange“.

~,.w

.‘v

y':--

v

«a

‘

�</text>
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                    <text>—.

v1

'w'..‘~"vvr\\.uvi

n '.\,«.~"\v.-

,~

n -.--..v~.-w~~,~.;$

;~.v.m~-.rv~.~

K"

a

,

—

nr.rv' nr'owvn

saw wum—x-wum—csr

.w-w

.v.

.v

.7,

mu“

.m

_..‘-.

V..-

_,.7nu

December 20, 1967
Dr. Joseph 6. Bird

Sterling-Winthrop Research Institute
Rensselaer. New York 12144
Dear Joe.
on

The meetings in Puerto Rico were
cyclazocine was well received.

excellent

and the

report

Dr. Cole did discuss his problems with me one I recognized
the difficulties he faces in trying to develop a new program.
I have read
My

the

new

protocol and

best wishes for the

New

it

is satisfactory.

Year.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Hszp

�</text>
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                    <text>December
Dr. Joseph 6. Bird

l3, l967

'
»

Sterling-Ninthrop Research Institute
Rensselaer. New York l2l44
.

Dear Joe,

After submitting the various preposals to the Research

Committee of the Medical College, I find

grantor's agreement

that

one form, a

not submitted. We would be grateful
if you, or another responsible officer of the Sterling»
Winthrop Research Institute would approve the agreement.
enclosed Ind return it to’mes
was

-

.

The
who have
minimum.

first

depression_study has an additional ten cases
received cyclazocine for a period of four weeks
I have asked Br. Simeon'ahd 8r, Zaks to summarize
the status of the patients as of mid-December-and we will
write a formal report during the first weeks of January.
With this group of patients we found that the dosage schedule
suggested in the proposed comparative study is a suitable one.
As

are
study.

made
Hy

soon as the supplies of oyélazocine and imipramine

available,

we

are prepared to undertake the comparative
‘

best regards.
-Sincerely yours,

-

Max

Fink;‘M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>March 21. l968

Dr. Joseph 6. Bird

Sterling-Hinthrop Research Institute
Rensselaer, New York
Dear Joe,

pleased to tell you that an abstract describing our
experiences with cyclazocine as an antidepressant has been
accepted by the American Therapeutic Society for presentation
at their Honolulu session on June 12 - l6. A copy of that
abstract is enclosed.
I am

-

to attend this meeting and present this
be
may
helpful to have Dr. Zaks or Dr. Simeon

I am planning

report. It
participate with

me

in the event

Is

it

My

best regards.

we

stimulate interest.

possible for Sterling-Hinthrop to consider sending
participant to this meeting?

an additional

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
P.S.

May I

remind you to send me the names of the

last

few

patientS'treated with cyclazocine according to your records.

�</text>
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                    <text>March

6. 1968

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute
Rensselaer, New York 12144
Dear

Joe,

The question of withdrawal symptoms upon discontinuation
of cyclazocine after extended use was discussed in the reports
published in the J.A.M.A. and to appear in the American Journal
of Psychiatry. Y3§~ﬁay recall that a variety of symptoms were
recorded by the patients upon acute withdrawal. These included
increased irritability, headaches. suspiciousness. depression.

a'hrippe-like” syndrome. The sy-ptoms persisted for one to
three days and were not serious enough to warrant treatment.

and

We concluded that in the usual treatment with
cyclazocine
the termination should be accomplished over a three to five
day period, much in the way the termination of imipramine
treatment is ordinarily concluded.

In those subjects who spontaneously stopped cyclazocine, we
have never had a complaint regarding any significant secondary
e facts.

It has been our impression that the withdrawal symptoms to
cyclazocine are of an order of magnitude and most similar to the
withdrawal symptoms reported for imipramine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>January 29. 1968
Dr. Joseph G. Bird

Steriing~winthrop Research Institute
Rensseiaer, New York 12144
Dear Joe.

Enclosed is a revised and updated capy of the report

of our EEG studies with cyciazocine. The originai was
presented at the ACNP meeting in 1966 and it is now going

to press.

‘

of the clinical experiences with cyciazocine
as an antidepressant is continuing and we should have a report
The review

avaiiabie very shortly.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max
NF: kp

enc.

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                    <text>January

ll,

l968

Dr. Joseph 6. Bird

Sterling~hinthr0p Research Institute
Rensselaer, New York l2144
Deer Joe.
I

have received the supplies of cyclazocine (0.25 mg) and

placebo to match.

I think these will suffice for the remainder
of study #l. I have asked Dr. Simeon and Dr. Zaks to replace
the active medication with placebo in each of the patients and
to observe the changes which follow.
May I take this opportunity to thank you for
your thoughtfulness
in sending me such a fine holiday gift. I took this
home and my
wife and I are pleased to thank you.
My

best regards.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

�</text>
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—

nIWMr-w-r

'Vnu‘ym.

wu—

May

Dr. Joseph G. Bind
Sterling Winthrop Research

chsselaer,
Dear-

New

York 121%

a,

1968

Institute

Joe,

Bmlosad is a cepy of the report which we
mad both in Tarragma and in Atlantic City. Irecently
believe
it will be published in the Proceedings of the GIMP.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

2, 1968

Dr. Joseph 6. Bird

Director. Experimental Medicine

Sterling«winthrop Research Institute
Rensselaer. New York l2l44
Dear Joe.
Thank you very much for your letter of April 25. The
9rant~in-aid in the amount of $400.60 will permit us to send
Dr. Simeon to the meeting of the American Therapeutic Society.
if you could request a check payable
It would be least involved
Simeon.
directly to Dr. Jovan
We

have completed the data requested by you

for the

FEA

in the depression study and are

the oyclazocine patients
in the process of completing the narcotic addiction group.
Both should be available within the next fortnight.
on

Thank you

for your assistance.
Sincerely yours,
Max

Fink, H.D.

Profesnor of Psychiatry

Mszp

�</text>
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                    <text>June 21. 1968
Dr. Joseph G. Bird

Sterling-WinthroP Research Institute
Rensseleer, New York 12144
Dear Joe,

Enclosed is a draft of a pharmacological study
of cyclazocine undertaken at the university of Tennessee.
at our request. This was presented at the Society of

Biological Psychiatry on June
in their annual proceedings.

15 and

will

be published

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Hfzkp

enclosure

�</text>
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                    <text>June 6, 1968
Dr. Joseph 6. Bird
Sterling Winthrop Research

Rensselaer,

New

York

l2l44

Institute

Dear Joe.

Separately

I am sending you complete data folders and
patients who received cyclazocine in the
cyclazocine-depression study at the New York Medical College

summaries of 19

and Nos. 072-098 of

patients receiving cyclazocine in the
treatment of narcotic addiction. I trust this data is helpful.
Thank you

studies.

for your assistance in carrying out these
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>Augwst 5,

ms

0h. Joeeph 6. Mad
Dace/talc, Expmnental Medicine

Sic/bung-Wmmp Rueaheh

Ramadan,

New

You: 12:44

1mm

Dem Joe,

the ewe}:

mm

as one eyelazocine etudéea in
ﬁnd
05 den/Luann. Theae have been Admitted to
05 the Medea: Joulmmt 05 Péycmy 50!: ha

EnclOAed ahe

the MWW
eomidehaﬂon

60):.

pubueaaon.

we AWu

The“. twa hepom and the
bummed in
June hephuent the emptetéon 05 can htudy mogmm with
eyetazaoéne 0.6 dueuued (in OM manombze medium both in
New: Yeah and Rweetaee
but yeah.
Lt

ha

been a. pleaawte

when StenLLnQ-MMMOp haA

acquae

My

continue this

to

week with you and I

«(mm
[11:20th evaCuaLéom

behavzomi. and

Wnehip.

m1: that

novel compoundb

Sineehdy
Max

Fink,

,

you/L6 ,

ALI).

that

we may

'

Phoéeuoe 05 Psychiathy

�</text>
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                    <text>September 6, 1968
Dr. Joeeph 31rd

Sterling Winthrop Institute

Reneeeleot,

New

York

Dear Joe:

I completed the report: of oycleeocine en en
cop} to Dr. Nathan Kline. He has expreeeed
the study. I know of no one in the ECDEU programs
when

entidepreeeent. I pent e

an

intereet

1n

who he: as good a record on he bee, in defining oer compounds. and
may be most useful for you to have him look at oyoleeooioe.

it

Inoideotelly. I have enquired about Tolwin in our community
and no one has been reported abusing this compound in our population.
Some of the etetf thought the: vo ohould look among the Village
population tether than the Harlem scene. A: upon ee my staff returns
from the summer exodus, I will discuss the ptogten with them.
My

bent regards.

sincerely yours,

Mix

Fink.

HOD.

�</text>
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v.

,
A

,V...,.

March

‘&lt;._V_V-.,,..&lt;.=.t._-v_....-,

To.

,..,,A

,ﬂm".

"Hy—.‘..,c.m

.

25.

1969

Dr. Joseph 6. Bird

Director. Experimental Medicine

Sterling-Winthrop Research Institute
Division of Medical Research
90 Park Avenue (5th floor)
ﬂew

York.

New

York lOOlG

Joe.

Dear

copy of our report as submitted to
and
czinicaz Phaamacozogy
Theaapeutica.

Enclosed is a

draft

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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W

July 28,

1969

Ir. Joseph 6. Bird
Director of
Maine
Resend: Institute

mung-um
90 Park Aveme

New

York,

New

York 10016

Dear Joe,
1M1): you for the two articles on
Win synﬂnsis inhibitors.
IhadﬂmeonebyW.Waybutrmthoadmr.

I,too,domtmthem1evmfwammmmkgm
Wtakmﬂnlibwtyofsmﬁmgitmtonmmn.

am, also, for sanding the cyolazoc-ine so may.
Shmly yams,

Max Pixﬂc,

Md).

meessw of

Psydxiattry

�</text>
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                    <text>December 22, 1969
Dr; Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute

90 Park Avenue

New

York,

New

York 10016

Dear Joe,
As a follow~up on your letter of December 4, enclosed
are the case records, dates of discontinuation and other

corrections requested.

Laboratory data on ambulatory patients

unsystomatic and unavailable.
My

best regards for the

New

is wholly

Your!

Sincerely yours,
g
:t‘wv

Fink, MD
Professor of Psychiatry

Max

17.1.

«.mwmmnmumrw-nvm-npwzw

MF:kp

�</text>
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                    <text>lair.ud

November 13, 1969

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-WinthrOp ResearCh

90 Park Avenue
New

York,

Dear

New

Institute

York 10016

Joe,

Enclosed are the latest group of reports on cyclazocine,
representing patients #0100 to 0114. You will note that most
of the subjects of this group received an induction period
which was much shorter than previously and as a consequence
suffered insomnia, floating feelings, nervousness and irritability.
In most instances we have given the patients oral naloxone first
as soon as symptoms occurred and more recently on patient demand.
Thank you

for your assistance in carrying out this study.
Sincerely yours,
Max

Fink, M.D.

Professor of psychiatry

Mszp

�</text>
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                    <text>”mu—Vw...”

March

4.

7 7,.

n

1970

Dr. Joseph C. Bird

Director of Expnrimenta1 Medicino
Ster1ing~winthrop Research Institute
90 Park Avnnue
new York, new York 10016

Dear

Joe,

to enciose two reprints of our paper “Ciinical
Antidepressant Activity of Cyciazocine - A Narcotic Antagonist“.
I am p1ensed

We

Stu dy.
Has

are gratefu1 for your support and encouragement in this
there been any progress

on a 1ong

cyc1azocine?
My

acting formu1ation for

best regards.

Sincere” yours ,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                    <text>wwmu‘w'w

.v

~

-,..._..,_.,—._.....—

m.__w_~.&lt;..m«

“.mwm‘w

October 9, l970
Dr. Joseph Bird

Sterling Winthrop Research Laboratories

90 Park Avenue
New York, New York

Dear

l00l6

Joe,

Enclosed are the available
program.

new

case reports in our cyclazocine

study is progressing well. we now have 52 patients in the
induction schedule is most satisfactory.
clinic..
The

The 4-day

I am

meeting.

also enclosing

a

reprint of the

summary

of the June

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

MF:kt

4

A

»

�</text>
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                    <text>September 27, 1967
Dr. Paul Blachly

University of Oregon School of MedicinePortland, Oregon
Dear Paul,
Thank you very much for sending me a capy of the
proposed
symposium at the forthcoming APA meeting. I hope that the
Program Committee will welcome this suggestion and I look

forward to participating.

It has been almost eight years since I participated in a
study of convulsive therapy, but your suggestions for HMECT and
the enthusiasm for unilateral ECT has stimulated me to under~
take another ECT study project. In my present facilities at
Metropolitan Hospital, the number of cases treated with ECT
are quite few and I have sought the cooperation of Dr. Lothar
Kalinowsky to study cases at one of New York's largest treatment centers. Gracie Square Hospital is well known as a center
ECT.
for

would like to obtain some support from the National
Mental Health and in doing so I would like to be
able to call upon you and Dr. Kaelbling as consultants. As
the originator of MﬁECT, I know of no~one more qualified to
advise us in the most satisfactory method applying this technique.
We

Institute of

May I have your permission to include your name
among the
consultants for the study ITheoretical Clinical Studies of

Convulsive Therapy?”
Many

thanks.

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>August 1%, 1967
Dr. Paul H. Blachly

Asmiate Professor

University of Omgm Modical School
3181 B.

San Jackson Park Road
Portland, Oregon 97201
W.

Dear Paul ,

lhank you for your

forming
new data

for the

enough

APA

letter of July

mothmgs.

regarding

EEG

I

clumgea

19, describing a panel

low if them is
in convulsive tMrapy

do not

except for your own work to warrant a panel. Perhaps, a numgeneral subject like unilateral and bilateral treatments or
single and multiple tmatxrmnts might be a more appropriate

subject.

If unilateral and bilateral are discussed , then you might
consider inviting Dre. Kaelbling, Martin, Cannicott
and Small.
There is a ymmg man who has just joined my staff,
Dr. Richard Abrams, Who has undertaken a series of studies

while in the military of unilateral versus bilateral and
multiple treatments. In this My he has made measurements
of changes in mmry and I bolieve he wold contribute to the
mm gemml panel.

I wmld

be pleased

to participate in either the

or the unilateral - bilateral program
Thank you

for the invitatim.
Sincerely yours ,
Fink, M.D.
Profoasor of Psychiatry

Max

MFtkp

EEG

discussion

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                    <text>“’5

"wwwv,

&lt;

1w—vr.’~.v.w

-,—

-a—n—.-v.»

my,“

a-—-

“,.._.,.v.

"f-..

,

,
~.~.5--

March 18, l968

”-mmw.

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
.V

.

own—nun,

._.

mwﬂ‘1varcww-v

3181 S.H. Sam Jackson Park Road

Portland, Oregon 9720l
Dear Paul,

visit and could show you
and
Gracie
at MetrOpolitan Hospital.
Square
what we are doing at
Because of the organization of our project, in which Dr. Kalinowsky
is the consultant, I would ask that you not contact Dr. Impastato
to visit our project because this may complicate the relationships.
I would be

pleased to have you

it

To meet the staff of the Narcotic Addiction Program,
would be necessary to come during the week and if Wednesday
or Friday are available these would be ideal. If this is not
possible, I would be glad to meet you on Saturday morning, but
I cannot speak
We

could

for the other

visit

members

Gracie Square on

me when you know your

schedule.

of the

staff.

either day. Please call

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March 18. l968

Dr. Paul H. Slachly
Associate Professor
University of OregOn Medical School
3l81 S.H. Sam Jackson Park Road

Portland. Oregon 9720l
near Paul,
what

I would be
we

pleased to have you

are doing

at Gracie Square

visit

and

and could show you

at Metropolitan Hospital.

Because of the organization of our project, in which Dr. Kalinowsky
is the consultant, I would ask that you not contact Dr. Impastato

to

visit

our project because

To meet

the

this

may complicate

staff of the Narcotic

the relationships.

Addictihn Program.

it

to came during the week and if Wednesday
these would be ideal. If this is not‘
available
Friday
or
are
I
would
be
glad to meet you on Saturday morning, but
possible,
I cannot speak for the other members of the staff.

would be necessary

we
me when

could

visit

you know

»

Gracie Square on

your schedule.

either day. Please call

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January 26. 1968
Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School

5.”.

3181

Sam

Jackson Park Road

Portland, Oregon

97201

Dear Paul.

project at Gracie Square

has begun and like all such projects
have obtained the concurrence of the staff and
appointed both a nurse and physician to the staff. I am recommending the
appointment of a psychologist whom I have Just met. The EEG equipment was
delivered this week and the laboratory will be set up early in February.
We have written some computer
programs for diagnosis using the Hamilt‘n
The

is progressing slowly.

Rating Scale.

We

expect to
bilateral treatment in
MMECT in the early summer.
and

'
.
*’

‘*2

I

make some
March and

A few days ago I received a phone call from Dr. Strain who heard
of my interest in ECT. He reminded me that he is coparticipant in our APA
panel, and while I have done little for that presentation, I look forward
to it.

I read your

notes

on

and the observations are very

'
M"

-'
’

-,.
-

12:11:.s,»‘~'=«;~

.«pr

1.0.2:»

"w

-

systematic observations in unilateral
and should be ready to start

April,

Pyridoxine.

interesting

this
further study.

I know nothing about

and warrant

compound

Enclosed is a preliminary report of our experiences with naloxone,
as well as a reprint of our cyclazocine data. Of the two drugs, used in
the same population, the naloxone gave us less complications, was better
accepted and seemed more promising as a therapeutic agent than cyclazocine.
I regretqi very much that we were unable to continue our study because the
manufacturer discontinued production because of expense. I am trying tn
every reasonable political way to urge continued production of the compound
for I think it holds much promise.

-.?r.".«':‘rW€;.-N+f.~.m.

Fem

ﬂat—ﬁle.

for

Incidentally, your

comments on acetylmethadol

are most interesting,

have never heard of this material. A year ago we asked Sterling Winthrop
(and were supported in our request by NIMH) to produce a long acting cyclazocine.
This has not yet been done.
I

My

WWW

"ﬂ

best regards.
Sincerely yours.

HT’VK-Willi-

'1713i75m7W-u72'v'ﬁ”

Fink, M.D.
Professor of Psychiatry

Max
W

FV‘T'

if"
—

5
~

MF:kp

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                    <text>May

Dr. Paul Blachly

University of Oregon Medical School
Department of Psychiatry
3181 S.N. Sam Jackson Park Road
Portland. Oregon 97201

’

Dear Paul,
Thank you for your letter of May 22. I would be pleased
to participate in the Institute, especially since Dr. Jaffe
will also be present. The idea of such an institute is new
to me and I probably will plan to be there on August 14 and 15.
I will plan to discuss the psychopharmacological treatment
of opiate addiction, emphasizing some of the newer experimental

approaches.
Your

run our

visit

encouraged us very much and I am planning to
ECT during the forthcoming week.

first monitored

Thank you

for your kind invitation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

’

"
~‘

.“"
‘

:‘ﬁw'vweanﬂhmw

kifﬁﬂW.-/

_

,W

ran?

29, 1968

�</text>
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                    <text>:7“.

April

ll.

##1va

l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l3l S.H. Sam Jackson Park Road
Portland. Oregon 9720l
Dear Paul.
Thank you

comparing

ECT

for your letter of April 4.
electrocardioversion.

and

and the

reprint

For your visit on May ll. we can arrange to meet you at
Gracie Square Hospital (76th Street and York Avenue) at l0:00 a.m.
on Saturday, May l. If you will let me know where you are staying
my associate. Dr. Richard Abrams. will be glad to pick you up and
bring you to the hOSpital. He can visit there and observe the
treatment program and i would then like to have you visit our
laboratories at the Medical School. while I cannot guarantpce,
a demonstration. i may be able to show you enough to make the

visit

worthwhile.

The program of Drs. Dole and ﬂyswander is the best program
for narcotic addicts in the city,(and possibly in the country)
and you should visit. Their principal center is at Beth Israel
Hospital which is at lath Street and Second Avenue. 1 would
suggest you write directly to Drs. Dole and Nysuander. indicate
your interest and your earlier experiences with addicts, tell
them of your invitation to visit our laboratories and ask for
an opportunity to see the Bernstein Pavilion on Saturday afternoon

or Friday evening.

A

visit

Your question about a
rings no hell with me. for

compounds.

should be very much worthwhile.

new beta adrenergic
I have not studied

Both Dr. Abrams and I look forward

blocking agent

it or similar

to your visit.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc:

Dr. Abrams

53%

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                    <text>July l8. l968
Dr. Paul Blachly

Associate Professor
University of Oregon Medical School
3l81

5.“.

Sam

Jackson Park Road

Portland, Oregon 9720l
Dear Paul,

for your kind invitation to participate in
the summer school. I know that you will be busy, but if
you are planning to treat patients any day that week other
than Wednesday, I would like to make arrangements to be in
Portland to, once again, watch the treatment administration.
Thank you

I

look forward to seeing you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>November

7. 1968

Dr. Pau1 H. B1ach1y

Associate Professor
University of Oregon Medica1 School
3181 S.H. Sam Jackson Park Road
97201

Port1and, Oregon
Dear Pau1 .
As

is typica1 for this time of the year. there are

studies under

many

The naioxone study was begun again and we
have recent1y given as much as 600 mg a day. Protection against
antravenous heroin seems to 1ast, at this dose at least eighteen
way.

ours.

In para11e1 fashion we have continued to expiore the
efficacy of methadone in b1ocking intravenous heroin and find
that at 100 mg per day. the subjects do not obtain a euphoric
response for up to 75 -heroin. at 1east for eighteen hours
after a dose; and for- mg for at 1east 36 hours.
The duration of methadone using this criterion is 1onger
than we anticipated. and we are continuing to exp1ore the
duration and dose response. Neverthe1ess. one of my staff
has proposed a study of acetyi-nethadoi. Hith our present
methods and experience. we shou1d be equipped to assess the
re1ative merit of methadone and acety1~methado1. not only on
the c1inica1 syndrome of addiction. out in the heroin cha11enge
criterion as ue11.

Before progressing with the detai1s of a protoco1. do
think
that suppiies of acetyi-nethado1 may be avai1ab1e
you
and in what re1ative quantity? If the supp1y is very 1imited.
as I think it might be. then we wouid suggest a simp1e heroin
cha11enge study in some subjects in when we have aiready
determined the duration of effect of methadone.
Our present detai1 studies of methadone shouid be comp1eted
by the end of the year and we cou1d undertake a comparison
study in January or ear1y February. Is
realistic for us

to continue this expioration?

supp1ies are indeed 1imited to ask
supp1ies avai1al1e?
My

it
be worthwhi1e if
it
NIMH
make

Hou1d

to

the
additiona1

best regards.
Sincere1y yours.

Fink, M.0.
Professor of Psychiatry
Max

,
w

NF:kp

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                    <text>‘3'.

K’Wﬂ‘rvﬁv'v

7"“

zrlw'nf'mmvmmm—menmw

w a

WWW

a“

-=

-

mi-

muwwwwm&gt; saw-m- Vl'mmumisrnmvww

‘K’E’mf:T’WF'W'VJYI'1'5‘7‘WS-WYW‘"‘.'¢W 'A—wﬁ'. "v- n~»y~m—aw.wm.m

November

mum-

-

v-w-r.‘

4‘

'-

- m-v.

,

=»

m

a

--

...,

»

..

w --

7, l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l81 s.w. Sam Jackson Park Road
Portland, Oregon 97201
Dear Paul,
As is typical for this time of the year, there are many
studies under way. The naloxone study was begun again and we
have recently given as much as 600 mg a day. Protection against
intravenous heroin seems to last, at this dose at least eighteen

hours.

we have continued to explore the
methadone
in
of
blocking intravenous heroin and find
efficacy
that at lOO mg per day, the subjects do not obtain a euphoric
response for up to 75 mg heroin. at least for eighteen hours
after a dose; and ford‘bm’g for at least 36 hours.

In parallel fashion

duration of methadone using this criterion is longer
anticipated, and we are continuing to explore the
duration and dose response. Nevertheless. one of my staff
has preposed a study of acetyl-methadol. With our present
methods and experience. we should be equipped to assess the
relative merit of methadone and acetyl—methadol, not only on
the clinical syndrome of addiction, but in the heroin challenge
than

The

we

criterion as well.

Before progressing with the details of a protocol, do
think
that supplies of acetyl-methadol may be available
you
and in what relative quantity? If the supply is very limited,
as I think it might be, then we would suggest a simple heroin
challenge study in some subjects in whom we have already
determined the duration of effect of methadone.
Our present detail studies of methadone should be completed
by the end of the year and we could undertake a comparison
realistic for us
study in January or early February. Is
Would
be
worthwhile
to continue this exploration?
if the
it

it

supplies are indeed limited to ask
supplies available?

NIMH

to

make

additional

.ve'x

My

www-

best regards.

uni-re

Sincerely yours,
mmavww

Fink, “.0.
Professor of Psychiatry

Max
"-a',

wan-M‘mmn‘

n

Mszp

r...

w «- r-

~»

-

-~

~

;,

-

.

,

.

..

v

.

.

ma

--

»

�</text>
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                    <text>w-m‘w".7"7,.r‘,‘w,,-m‘vw~..m&lt;warn mum

v

.

vv‘V/Wﬁﬂ'

uv-w WV .- n

IXWIruwlnuwm-w-wg

rump-“WM w—u- "tA-Wrmﬁ‘wlﬂuA'mmimw.~-v..n-—u‘..._..,-u

_,,.

.mttmmvwvw .m-wv..-“

August 11, 1976

Paul Blachly,

M.D.

University of Oregon

Portlan,

V

ﬁnnr‘.

,—~;~.~wmwvz

1......

www.—

ear—w

Oregon

Dear Paul,

I want to congratulate you on a fine issue in the latest
I note on my return from my holidays that a number of
readers have taken your advice and written for preprints of my articles.
(Incidentally, the one on cost/benefit was sent to Dan Freedman. He sent
it to 5 editors, and each chewed the report over like it was a
favorite bone-- criticizing the length (too short and too long); critic—
izing the inclusion of schizophrenia (EST is not a treatment, only a
sedative); criticizing the language (too loose, needs tightening); etc.)
(#3) of

GTE.

s
n

arm

——r-ww,vn

vr'wawlr-er'

W

writing with regard to the announcement of a course
I would so like to cooperate and participate but the dates you
suggest are those that conflict with the APA Divisional meetings in
New York where I am scheduled to give a report on EST. If it is still
possible to change the dates, perhaps the next week-end ? Indeed any
week-end thereafter in November will find me in California.
on EST.

I

am

WWW

"Wv

"am-w:

sure you have written to the APA NEWS-sad the announcement to
I believe. I would also send it
Med
Sabshin asking his intervention for its publication in
directly to
the newspaper. Otherwise it will get lost on page 35 or so.
In addition, I

am

Mr. Robinson,

My
erme—rqqu—u

regards and agaén

my

congratulations.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

P.S. This

letter is not for quotation, please.

m- :rwwuv-uw

_,_, ,

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                    <text>December 22, 1971

Dr. Paul H. Blachly
Professor of Psychiatry
University of Oregon Medical School
3181 S.W. Sam Jackson Park Road

Portland, Oregon 97201
Dear Paul;

again, I find your questions thought—provoking and most
relevant to public issues. I accept your premise that ”those who are
physically dependent or have been so in the past” should be admitted to
methadone programs ~ and our program is limited to those males with at
least a Zwyear history and one confirmed treatment failure. In answer
to your questions:
Once

(1)

We

(2)

I

(3)

We

do

not use naloxone to screen routinely.

know of no program

that does.

do not use naloxone to screen, for we admit all patients
to the ward, observe for withdrawal symptoms, and then detoxify with methadone if symptoms are observed.

to run a large methadone program, I would use naloxone
give naloxone for test purposes auout 4m7 days post—withdrawal
(0.8 mg IV) 24 hours (or more) before we give heroin challenges. At various times, 3-6 days after the last does of methadone, our patients have
had chills, piloerection, irritability, and insomnia ~ sufficient for the
staff not to wish to do a naloxone challenge routinely.

tests.

Wereel

We

(4) About prisoners, your suggestion is interesting. In nor~
subjects, naloxone has no effect on behavior, pupils, heart rate, or
EEG. In the recent post~addict, symptoms are precipitated.
I do not know
what to expect in an addict, ”clean” for some weeks or months, although I
would anticipate he would be like our normals. Surely, a man claiming to
mal

be dependent - and using opiates within
easily by a naloxone test.

3—6

days

-

would be

identified

�(5)

The suggestion about naloxone's

availability to police and
objection would be the rare sadist who would enjoy the discomfort of precipitated abstinence - but this
is a miniscule risk compared to the possible saving in overdose deaths.
I would anticipate a coma from non~opiate cause would have no adverse consequences from the naloxone.

ambulance

drivers is brilliant.

On two

The only

occasions, in patients receiving

100 mg methadone

daily,

our heroin challenges (50, 75 mg) elicited euphoria, respiratory slowing,
and miosis
evidence of insufficient blockade (cross-tolerance). We gave
1 mg naloxone IV, and in each case, precipitated a severe abstinence
syndrome, unresponsive to additional heroin, methadone, and chlorpromazine,
and being relieved only by time (3-6 hours).
—

Note also, that naloxone IV is usually effective for
only and in overdoses, must be repeated frequently.

2—3

hours

I would support the suggestion that naloxone be freely available
to ambulances, police, physicians', and pharmacies; would not object to
an over—tne—counter availability; and would encourage studies of naloxone
in prison (or hospital) units as a test for eligibility for methadone maintenance.

Incidentally, our acetylmethadol study is completed and it coninitial optimism in 1969. It will appear in JAMA a copy is
enclosed for your interest. Also, Eur first trials with naloxone pamoate
firms your

—

began December 16.

My thanks for the good wishes
about these provocative questions.

—

and

for the opportunity to think

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

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                    <text>.

February 8, 1972

Paul H. Blachly
Professor of Psychiatry
University of Oregon Medical School

Mr.

3181 S.W. Sam Jackson Park Road
Oregon 97201

Portland,

Dear Paul:
Your letter regarding Congressman Pepper's bill is interestI do not know the bill in question, and can only comment on
your questions.

ing.

In general, in our study of the narcotic antagonists, I have

found the FDA verbally c00perative. Their dependence on rigorous
and extensive animal toxicology data has prevented human trials of
M5050 for 2 years, since we have been unable to find $30,000 to pro—
vide this data. The same attitudes have caused delays in studies
of BC~2605, and added immeasurable costs to studies of naloxone.

to your suggestions, I believe these are useful and may
- who discussed some
proposed changes in his section of the FDA at the recent ACNP meetings.
As

be in the process of adaption by Elmer Gardner

I would not encourage another committee. The present NINEcommittee reviewing protocols for drugs is sufficiently restrictive and limiting in its views (E;E° of cannabis) to provide a lifetime of delays and excuses to stifle research another could do

FDA

little

—

good.

I

not encouraged to attempt redress by the Congressional
or committee routes both are fora for selfish ”politics" interests
and not effective roads to research. The latter can only come from
the scientists assuming the burdens of research and challenging the
variOus agencies' on a case by case basis. Perhaps it is in the
education of our colleagues (345., the limitation of unsophisticated
dependence on animal trials) that our hopes and opportunities lie.
am

—

Sincerely yours,
Max

MF:ig

Fink,

MA).

Professor of Psychiatry

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cvu-«sqa-urxwvw-wrmmmm-umm‘.wwg—uuuwpmvmmw‘

--

V,

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,n

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A
&lt;

.w,

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wuwvvvw-m.

July
nummww

-

Dr. Pent-y Black

1967

6,

Divisicn of Neurological Swgery
The Johns Ibpkins Hospital
601 North Broadway

Baltimm, Maryland

.

.

21205

Dear Dr. Black:
Thank you very nuch fer yaw kind invitation to participate
the
"Drugs and the Brain." I am pleased to participate
this pmject and will try to provide a general medical summation

swim:
of the mm: state of
in
in

the

£3213

in mlatim to psychyphamaoology.

IbelieveIcanmtymmdaadlim'ofOctobex‘landmyhave

initial dmft available wlier.
Good

luck!
_

Sincerely yom‘s,
Fink, 3-2.1).
Professor of Psychiatry

Max
Mf'ﬂcp

cc: Dr.

A. Ian-land

‘

�</text>
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                    <text>vaember 21,

1967

Dr; Party Biack
Jehns Hopkins Hospitai
'

601 North.8roadway

Baltimore 5, Maryland

Dear

0r. Black:

writing with regard t0 the symposium "Drugs and the
Brain.“ You were kind enough to invite-me.to submit a manuscript
and I suddenly realized that the date for submission has passed.
I am

At the request cf the ACNP, I'am in the midst of an extensive
review of Iiterahure and wiii be pleased to make the kind of
presentatien which you requested, provided that the deadline

can be moved up to mid—Becamber. I shal1 try to have an'appropriate
manuscript avaiiabia for you by that time.
'

-

Sincereiy'yaursg.
'Max Fink, M.ﬁ.

Professor of Psychiatry

Mszp

�</text>
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January 25. l968
Dr. Perry Black
Division of Neurological Surgery

Johns Hopkins HoSpital
60l North Broadway
Baltimore, Maryland 2l205
Dear Dr. Black:

Enclosed are two copies of the report "Orugs, EEG and
and the
Behavior." as a contribution to the symposium "Drugs
Bra n.‘

mammm

.wn‘

w"

1:
u,

is.

For publication purposes the prooer academic affiliation
Professor of Psychiatry. New York Medical College.

31-me-

Thank you

Wm

r

for your kind invitation.

"'

1;:-

Sincerely yours,

.
~,\,/€?:Il,

1»;ngst

Fink. M.D.
Professor of Psychiatry

Max

wan-man:

&lt;WF“K:V(J!Z-!‘

QWER'm-J-mewat

‘-'
W?

‘-’-”'?'-'«""‘

:»

raw-«xv

i""ww1eermmi-1

w

mmgm

IZZY-.7

Mszp
GHC.

�</text>
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                    <text>May

9, 1968

Dr. Perry Black
2006 South Road
Baltimore, Maryland 21205
Dear Dr. Black:

Enclosed are corrected pages for the manuscript
"Drugs, EEG and Behavior" following your suggestions

0:

‘mrr-wu—

—-

yesterday.

free Levin for the whole
volume, although if reprints are to be made available
if the publisher
to the authors, I would be grateful such
use, set up my
would, as partial compensation for
reprints with this paragraph as a frontispiece.
Table II should be corrected so that the heading
You may

use the quotation

for:

.

Ia

Mai

nly increased s].oving
Alpha
Seizure Activity

Increased
It With
Ic With Increased
IIa With Increased
IIb With Decreased

Amplitude
Amplitude

in each column should be listed alphabetically,
but the parentheses should be maintained wherever indicated.
of
Also, in Table II the type selected for the title
be
should
class IV and V, alpha increase, alpha decrease,
and
Page
7,
III.
for class I, II
the same as the typeface
h marked in italic are to be rpplaced by
3
and
paragraphs
the paragraphs appended.
On page 8, a footnote should be added with the asterisk
after the word "phantastica". The footnote is appended.
EEG Applications” should
The title on page 8, "Clinical
The drugs

—

be

deleted.

page 9, the two paragraphs relating to the
should be replaced by the paragraphs appended.
On

deliriants

�-2-

Dr. Black

references
as follows:
The

May

on page 2 and 3 can be

at 3;. Digital
Psychophernacology.

9, 1968

brought up-to-dete

Analyses in
In Kline, ﬂ. and Leeks E.
(Eds) Congntere and Electronic Devices in Pezchietrz,

Fink

Grune and

Computer

Stretton, H.Y., p.

EEG

109—123, 19

.

Itil, T. and Fink, M. EEG and Behavioral Aspects
of the Interaction of Anticholinergic Hallucinogen:
with Centrally Active Compounds. In Bradley, P.
and Fink, M. (Ede), Antioholiner ic Dru e, Eleevier,
Amsterdam, p. 1&amp;9-163, 1937.
The citations should be changed on page 8 from Fink 35 e1.
(in press [a]) to Fink 33 e1., 1968. The reference to the
other citation was changed in the section on deliriente.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>February 9. 1969
Dr. Perry Black
Johns ﬁcpkino Hospital
Bgltilora, Haryland
Dear Dr. Black.

thé page proof: of tha section of ch»
forthcoming book, chapter 10.
Enclouod

at:

There arc {cw typographical errors and than: are marked.
Thurs are non. prebleut in thg way the tax: reads, and attmr re~reading
this an Friday. Saturday and tldny. I reacted with sown caneern. I! the
vulva. is co hava wide diatribucion (and I have
does), the chaytcr

it

rctloets thc oditorn not: than mysalf.

Rance, the changal and the rntnrns noted. I

am

confident

will rccagntze the idiosyncrasies involved; baththan, the
article is written under my mama and not that of the unknown aditors.
Plans. accayt each of the changas, as marked, aven if the usage is
that

you

improper by the standard: a! the Johns ﬂopkins $resa.
Thank you

of

my

lettct

for your coopcracion.

and

my

hast ragards.

In the cvcnt chose suggestion: tr: untcnublc. tha tcacriction
of November 17, 1968 still holds.
Sincorcly yours,

Ht! Fink,

M.D.

Profs-tor at Psychintry

at!

�</text>
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                    <text>November 17, 1968

Dear Dr. Black,

Enclosed are the corrected galley proofs of my contribution
to the volume 'Drugs and the Brain'. I have answered your questions
and brought the references up~to~dste. Unfortunately, I could not
follow your injunction to limit the changes to those of scientific
accuracy. I have made many corrections in the text.

In some places, your editorial assistants made useful
suggestions, and these have been accepted. In others, the corrections
clouded my meaning. I have indicated the text which I prefer, and
which must be accepted for the contribution to remain in the volume.
Despite your plea that the English specialists made corrections
which you had to accept, I remind you that the production of an
article of this type is the creation of the author; and not a

joint endeavor.

In the event that you or the editors wish to change
s single word or a single frame of punctuation, please accept this
note as a withdrawal of the complete article. The suggestions
could have been submitted to me before going to galley; and the
plea that it is too expensive to make changes new is regrettable
but completely yourr responsibility. If you have any other
suggestions, please make them in writing before setting them in
type.
For some years I have found increasing disregard of
the idiosyncrscies of authors by the 'so-cslled' specialists
asked to review the articles by scientists. If the text is
unsceeptsble,then please reject the complete text. But the
text is mine; and not that of the Johns Hookins Press. Nor, for

that matter, yours as editor.

Please honor me by returning a corrected galley proof
for my signature. If no galley proof is submitted, I must insist
that the article be withdrawn, even if you find the corrections

acceptable.

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

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                    <text>&lt;

v:

.11--‘

November 17, 1968

Dear Dr. Black,

Enclosed are the corrected galley proofs of my conand the Brain'. I have answered
and
the
references
questions
brought
your
up—to~dete.

tribution to the volume, 'Drugs

text.

In

You

many

will note that I have made many corrections in the
places, the editorial assistant contributed to the

clarification of the message; in others, the corrections clouded

meaning. Despite your plea that the corrections be limited, I
insist that ALL the corrections be accepted as made. I regret
that neither you nor the editor saw fit to send me a copy of your
suggested corrections; for had I had the text before it was set
in type, much expense would have been saved.

my

must

If you or the editors feel that the corrections are
unacceptable, I request that you Withdraw this contribution and
I will submit it elsewhere. It is my belief that the author is
the principal artist in the presentation, and I insist that not
a single comma or word he changed without receiving approval in
writing. All the words appear in the dictionary, and you or
the editors are free to put them in sequences of your choice; I
choose the sequences submitted, and these sequences are my creation.
Such an endeavor is not a joint enterprise and I cannot accept the
suggestion, even by implication, that an editor, even one presumably
specially selected by the esteemed press of which you are the servant,
can alter the text.
your

I regret that I must

letter are unacceptable;

those changes that I could.
indicated, must stand.

~&lt;

insist, since the suggestions of

as are the changes. I have accepted
the corrections as

The remainder of

I trust those are acceptable.

/'-:g

Y‘s-h

1

7‘

i
-.rW-v.'r‘

31

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MF/

�</text>
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                    <text>heir—In

‘

January 31, 1967
Dr. Lionel H. Bleelanan

2035 Lakeville Road
Park, New York

New Hyde

Deer Lionel,

a pleasure to visit with you at the NP Society,
and I was especially delighted to hear of your ECT study progzem.
Enclosed is a reprint of my present theoretical view of 801',
andIbelieve that it isnottoodifferent fmyomnom. In
addition, I am enclosing xerox copies of two articles which
may be of special interest since they describe the differences
between unilateral and bilateral EC'I‘. I am pleming to undertake a study of these two forms of treatment at the New York
Medical College early this fall.

It was

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hatch 30. 1972

Dr. William Blackmore

Sterling Winthrop Research

Institute

Reusaalser,

ﬂew

York

Dear Dr. Blackmore:

Enclosed are case reports of patients inducted in 1971,
to be added to our files at the Institute.

Sincerely yours,
ﬂax Fink, ELI).

Professor of Psychiatry
Mfzig

Ens.

-,
n.‘

�</text>
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                    <text>January 31, 1969

unnu-

“35.1w."-

YA-"chev"‘!w,

0-0.2”:

mump

Dr. William P. Blackmore
Director, Clinical Pharmacology
Sterling—WinthrOp Research Institute
Reusaelacr, New York 12144
Dear Dr. Blackmore:

is in reply to your letter of January 27, reatating
your intention to withdraw the Sterling-Winthrop IND for
cyclazocine as an anti—depressant.
This

Studies of cyclazocino as an anti-depressant were
concluded in the spring of 1968 and a summary submitted to
Dr. Joseph Bird. No additional patients have been treated
with cyclazocine as a potential anti—depressant since that
summary was completed.
qu-‘e:

_.

_-..&lt;

-

"WW,

man:

The remaining supplies of cyclazocine that we used in
the treatment of depression were transfered to our narcotic
addiction treatment evaluation program and have been used in

that program.

Sincerely yours,

”,ua'uktvmrd:

(:2?!

r:

.

:A
#4:

Fink, M.D.
Professor of Psychiatry

Max

W713M72

“37:1,!

:-

“Hagggmgm

iii-721".

MF:kp

�</text>
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                    <text>Januaty 10,

1969

Dr. B. Blackwell, M.D.

8. Merrill co.
Cincinnati, Ohio

Wu.

Dear Dr. Blackwell,

I have read both the information btochuro and the proposed
protocol for otudios of Bimothocrin in dopreasivo disorders. While such
problems are of interest to this laboratory, we have recently decided that
our energies were better spent in the analysis of EEG profiles of new
compounds. to determine the logical populations of risk and the classification
'

of the compund.
Snob

special interns: to
chemical structureo, and we would be pleased

profile analyses

havo boon of

industry in the study of new
of interest to
to review the animal pharmacology of oompoundo that oro boon
decided by
hovo
you. The oloasifioation of this compound seems to
Co.
has
apparently
tho Swiso workers and the research staff of ﬁerrill
If this interpretation is incorrect. and
accepted this determination.
chore is intoroot in teviowing the population of risk for Dimethacrin,
I would be pleaood to review the data with you.
.Good luck

you

at the next

itself.

in your

ECDEU

new appointment, and

meeting, at

I look forward to meeting

earlier, if the opportunity presents
sincerely yours,

I

mf/

max Fink, M.D.

�</text>
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                    <text>J's Uw-va'rwt'evx- «mm.

‘VV—WK,"""\'W

aura-rm

—-

.v-.:

v

erm'ﬂ’lW'Il‘AvrqvnwmAm-xw'VWWrw-vnwl‘wrrﬁ'nx-Ynuww- . uv-WV—

May

——:~r.-v

,.-

1‘.

"WW "
v

cw...

run-WW...”

- v—vv

exvvv-

26, l969

V

.‘_.4_

,._.._

Dr. Barry Blackwell
Wm. S. Merrell Company
Clnclnnatl, 0hlo 452l5
The

.r.——,,....,

rev,

..

Dear Dr. Blackwell:

lt was a pleasure to dlscuss our drug evaluatlon programs
durlng the recent meetlngs of the Soclety tor Blologlcal Psychlatry.
Whlle we have undertaken many cllnlcal drug trlals In psychotlc
and neurotlc subjects, we have found these of less relevance to
our eventual appllcatlons than our EEG studles whlch show
lnterestlng predictable relatlonshlps. Untll we have exhausted
our lnterest, we are devotlng our prlnclpal cllnlcal energles
to

comblned EEG-cllnlcel
A

"w

trlals.

sample protocol and some

relevant reprints are enclosed.

”to

.v“,

“FEW.

.«mg»..,.,.

you

lf these

vlslt

methods

lnterest you,

I

would be pleased

our laboratories to discuss your compounds.

Thank you

for your Interest.

y—my—

Slncerely yours,
Kev»

Vv-I-‘T

mm

WWW:4:

aw"..-

\w

'va

vr‘l-wv.

“NH-J

m
‘

Flnk, M.D.
Professor of Psychiatry
Max

to

have

w.

.... . m-

.

..

.V

v

.n

.

�</text>
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                    <text>n.
;

w

m-

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urn—arm

a-rsw

mun-w

g

May

26, l969

Dr. Barry Blackwell
The Wm. S. Merroll Company
Clnclnnafl, Ohlo 452l5
Dear Dr. Blackwell:

pleasure to dlscuss our drug ovaluaflon programs
recon?
moeflngs of lhe Soclofy for Blologlcal Psychlafry.
during fhe
Whlle we have underfaken many cllnlcal drug Trlals ln psychotlc
and nouroflc subjecls, we have found These of less relevance To
our eventual appllcaflons Than our EEG sfudles which show
Interesting predlcfablo relaflonshlps. Unfll we have exhausted
our lnlorosf, we are devoflng our prlnclpal cllnlcal enorgles
to comblned EEG¢¢llnlcal frlals.
l?

A

was a

sample profocol and some relevanf roprlnts are enclosed.

If fhese mefhods lnforesf you, would be pleased #0 have
vlslf our laboraforles To dlscuss your compounds.
I

you

Thank you

for your lnferesf.
Slncerely yours.
Flnk, M.D.
Professor of Psychlafry
Max

MF:kp

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January 26, 1986
Joan M. Blaies, R.N.
Director, Mental Health Nursing

Waukesha Memorial Hospital
725 American Avenue
Waukesha, Wisconsin 53186
Dear Ms. Balies,

You are, of course, free to use the model consent form form my book, and

to modify it as you may need. i am pleased that it may serve a useful purpose. The
issue of consent in psychiatric therapies remains complex; it was a central issue at
the 1985 NIH sponored ConsenSus Conference on Electroconvuisive Therapy.

that the patient and the family have been given
sufficient information about the ECT process, which remains a surgical type
procedure in psychiatry? One answer is the diligence of the psychiatric staff in
How is one to assure

explaining the procedures, and in the training and experience of the therapists. But
since guidelines for therapists are not established, nor for consent procedures, we
have come up with another solution, that of an informational videotape. 0n the
invitation of Somatics Inc., producers of the THYMATRON, l participated in
making two videotapes, one for patients and their families and the second for
therapists. These may be of interest to you and your associates and I have asked
Somatics to send you a description.
'

WVWPWWMWV

Good luck in your work.
wrwvu—m

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

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5

February 25, 1971
Daniel Blain, H.D.
2100 Clarkson Avenue

Philadelphia, Pennsylvania 19144
Dear Dan,

There is one member of the Association, Joseph Zubin, who
has been most intimately involved with the association for half
its lifetime. He has written the most recent history (1965) and
I have asked him to answer your inquiry.

affiliated with Hillside Hospital, and
of the dramatic impact that Israel Strauss played
in New York psychiatry between the two World Wars. While Hillside's
impact on American psychiatry may be considered modest, it had a
great influence on New York psychiatry. Historical notes can best
be obtained from Joseph S. A. Miller, the medical director to 1961.
came

For ten years I was

to

know

Also, many research institutes were established with much
enthusiasm and optimism as the way to cure schizophrenia during

the 1950's and 1960's. I was intimately involved in setting up
the Hissouri Institute In St. Louis (1962—66) and notes about
this history may serve as an example of this trend. But then
you could document the centers in Omaha, Galesburg, Iowa City,
New York, 335,, with as much profit.
Good

luck in the project.
Sincerely yours,
Max

Mszt

Fink,

M.D.

,.

-.

.

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                    <text>me—n ""erm
r

‘1’;

July 31, l97h
Samuel T. Robertson, III
3267 Queenstown Drive
Mt. Ranier, Maryland 20822
Dear Mr. Robertson,

Division of Biological Psychiatry of this Department is as
that it is relatively easy to describe the work in progress.
The senior faculty consists of myself, Joseph wortis, M.D., and
Harvey Karten, M.D. Other scientists contributing or collaborating with
our work are Bernard Tursky (Political Science), David Krikorian (Botany),
The

yet so new

and Michael Gazsaniga (Psychology),

to

‘
..

name a few.

work is in two directions—~ the measurement of
electrical signals from the scalp of man using digital computer methods
and correlating these changes with dose, type, and duration of action of
psychoactive substances, both therapeutic and those of abuse; and a
clinical study program evaluating the efficacy and safety of new
treatments for menttl illness under grants and contracts with NIMH
and NIDA. Dr. Whrtis is a specialist in developmental psychology
and the editor of Biological Psychiatry. Dr. Karten is a neuroanattmist
Most

of

my

tracing pathways in the brains of pigeons. Mr. Tursky is a psychophysiologist who is measuring bodily functions as predictors a!
attitudes and voting behavior. Prof. Krikorian is interested in the
botany of khat, another of the substances of presumed abuse, used in
East Africa, and which may be the subject of studies of its neurophysiology
and psychological effects. Prof. Gasssniga is known for his studies of
the split brain, and these issues continue to excite him and the students.
My laboratory consists of the usual neurophysiology
Hiinstruments and an IBM 1800 computer for the analyses. We recording
spend much
time with studies in volunteers, and usually have 2~3 fellows in residence.
Should you visit the campus, you may wish to visit the laboratonies. If
so, I suggest you call in advance ($16 hhh 2hh7).

Thank you
‘

for your inquiry.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.

�</text>
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                    <text>17

.
n—w,

Wm:

"er

.-.-n

wan»

.

"any“.

‘

t..-.‘-,_r.,..,....

if.

7.0

.ww,..w,_......__

__

~_m1-qu»w.—_,mn- .ﬂtwm—mwmmwwm. .d .m

-

mwwv

‘4‘W'V'~

March

.. -‘ ,, 7., ...u

6,

,

.

.

_

..-,

v

.7...

u» -

N

v

7

in

._-.

....

....- "r...

1970

Dr. G. F. Blane
Rackitt &amp; Sons
Hull , England
Dear Dr. Blane,
Tue

yanrs ago I wrctv to obtain information on

narcotic antageniats, particularly SOSO—M. it the recent
NRC meetings in Washington, a format associate, R. E. Lister,
mantioned that you had worked on a long~aeting narcatic but may
have discardad it because of its unusual length of action.
long acting narcotic with cross tolerance to opiates
useful adjunct in the treatmant of cplatm
dapendence; as would a long acting and potent narcotic antagonist.
A

would be a most

I am writing to raquast any infatuaticn that may be availahle
regarding patential human trials with either 0f these compounds.
Bava trials with 5050~M progressed to aageasments in man ? Is
there, indeed, a vary long acting analgaaic with cross toleranca
to opiates available ?

bafcre, we are actively involved in
of
these
aubstancea, and unuld appraciate the
trials
opportunity to extend theaa investigations in any masningful

human

As we wrote

way.

Thank you

far your assistance.
Sincerely yours.
Max

Pink, M.D.

Profesaor of Psychiatry

mf/

cc:

A. M. Freedman

,_

"y:-

,

.4 w

-

7-“

-.

‘

,

V...,

-

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—

�</text>
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                  <elementText elementTextId="103300">
                    <text>33?"

'3‘ wr-rvmmumu‘nmmn‘w.“ﬂ

-...-,

,

-

w

«lax-war

May

Dr. G. F. ﬁlana

Clinical Research
Rackiff

&amp;

Calman

4, 3970

Co—Ordlnafor

Dansm Lane

Hull, England
Dear Dr. Blane:
Thank ycu

for your reply

To my

inquiry about

SOBO—M.

are lndeed Inferesled ln Gaveloplng a long~ac+ing opiafe
anfagonlsf, and if some clinically usable supnlles of 5050~M ware
available, would be wllling To underlake or underwrife The Tesfs
nacessary for an lNDA.
We

I

am

no? acquainted wlfh 320~M, bul will Try To obtain lhe
which i presume comes from Dr. Seevers.

available dafa,

leek forward +0 gafflng logefher in July in New York and
ask fhaf you write as soon as your Trip plans are crystallizad.
l

Slnceraly yours,
Max

Fink, M.0.

Professor of Pchhlafry

Mszp

.m

.,r

awry-u

warms;

w

.A,

mum-nay”;

"fully”

A

.

.

*wzmmnnrr'“

�</text>
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                  <elementText elementTextId="105898">
                    <text>“1,”,7,”

.__,

,.. .._.,..r

.

.,

"um.

..

7.,w‘Jg 7W a V...”

r M-

3.71.1.1v-71 sung-n.1,

1

.1

1.1,.

inquu‘wﬁ‘rw,, ..

1,,.-cv:-:.,,r

1h

.wwxum~r:mwrr ‘gt‘cwmuew‘kwrﬂ‘ W"

w‘uué

vmwa-w

June 23, 1970
Dr. G. F. Blane

Reckitt &amp; Colman
Hull, England
Dear Dr. Blane,

?

?

and

I look forward to meeting you on July 15;
will arrange to meet either in the city or at Kennedy

airport, whichever is
Hay

L

g

most convenient

for you.

I suggest you call me on July
? I can be reached:

to confirm a time and place
0700—0830

13

1900-

516 466 5444

(home)

1000-1730

212 369 8488

(office)

I look forward to your

visit.

Sincerely yours,
Max

mf/

Fink,

M.D.

or

14

-,.~,..

_

“u. .~,-~

,,.

-~ww-~

&gt;,ay-w-

r‘w‘-'.n&lt;-r'M-Vnm

.1.

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IPZMF" 1”

�</text>
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                    <text>i

‘31

t

41

mm... 7..

mmrvvﬂvw-mw u..." ”——

..__._‘

“WM—mm...

WWW...

"T.

.

l...

Mm,

_._..

v
...

r-'

1.,._....

..,..

Vm"v

March 5, 1971
wmpm-x-uwmwuhv-v

Dr. G. F. Blane

c/o Etabliasement Reckitt Ltd.,

3? 31,
m...

"F“,

15 Rue Ampere
91 Messy, PARIS

5'4:

”I'v—mn—T‘

Dear Dr. Blane:

Since receiving your

Amn-

ww’v-

letter,

we

have:

"-—

~v'

--

of Masosn.

w"

y-w‘vrz"

‘

Im'rz-mr'

ry-H-rl'ﬂﬂr'éﬁﬂ'v-‘W'V'wwu""ﬂ""v‘7‘m

N.Y.

our

(1)

Requested release of our funds for the animal toxicology

have a reasonable bid from Food and Drug Research of
[The release should be approved by mid~March; the study April-June;

FDA

We

filing in July.]

(2) Requested funds in our 197l~72 budget for u~snso, using
your figures as a guide. Because the price is as high or higher than
naloxone, we are not sanguine about an allocation, unless our naloxone
situation becomes critical. We did ask about supplies, and it wee useful
that we did so, since the cost difference between naloxone and
M~5050
appears to be slight.

mu

(3)

N'"m"m’x

“ovulﬂgﬂwul‘

w-I:

aw

mew-5'33"

:Mgmvw-rr-wrwan

non—committal

have written to Dr. Jack Danton and received a friendly

reply.

Based on these data, we will possibly go on with the M~5050 toxicology;
and request a small supply for human study by the parenteral route.

Incidentally, we recently received 6 kilograms naloxone for our chronic
oral studies, and these are in the data collection phase.
The article appeared in Buéincaa week. A copy is enclosed.
Many

.
.

new."

We

thanks for your interest

and

cooperation.

Sincerely youra,
Fink, M.D.
Professor of Psychiatry

max

Mszt

�</text>
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                    <text>May

18, 1971

Dr. G. F. Blane

Divisional Projects Manager
Reckitt &amp; Colman

Dansom Lane

Hull, England
Dear Dr. Blane:

if you

received the enclosed letter dated
as of that date, and
there have been no material changes since.

March

I db

not

5, 1971.

know

It represents the status

are trying very hard to obtain funds, but with the
present pressures on both state and federal funding to sustain
the war in Viet New and our war against poverty, the fight
for addiction seems somewhat hopeless.
We

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
811C.

�</text>
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                    <text>July 23, l968
Dr. G. B. Blane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons. Ltd.

Hull. England

Dear Dr. Blane:

of the MAS-NRC Committee
just read the l968 report
reference to the
on Problems of Drug Dependence and note
meeting,
narcotic antagonist M-SDSO. As we presented atin that
treatment
the
we are particularly interested in antagonists
I have

of opiate dependence.

data is
Has M-SOSO been assessed in human trials? If the
we
are particularly
available, I would appreciate a citation. since

interested in its duration of action.

are supplies available for
If it has not been assessed,
clinical trial or will they be available in the near future?

are interested in making such assessment if supplies
with
could be made available. since we already have experience
cyclazocine and naloxone.
Sincerely yours,
We

Fink. M.D.
Professor of Psychiatry

Max

mf:kp

�</text>
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                    <text>T

“

w-

w.n~w.r—-~ntr-v.-r-u .. ...
,

.

w.

"my... ‘_

1r»wr:t-

_

.

~4v-.~:.~,—m--m;n,--m»v..‘u

w,—-

W»

‘0'." V"U'-v,—w-r~—

w-

.v

v...—».,ku.ru-u.---~

-.,

vn

~-

»

~

-»-~ .

. ..., '-W-

F5.

August 8. 1968
Dr. G. B. Biane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons, Ltd.

Huii, Engiand

Dear Dr. Biane:
For the past two years we have studied the conditioning
theory of narcotic addiction as expressed by Wikier. We started
with cyciazocine and carried out some studies with naioxone.

Cyciazocine has the disadvantages of a narrow therapeutic
index and naioxone appears to have a very short duration of
action. Despite these iimitations, both treatments appear to
foiiow the deconditioning modei and have shown sufficient promise
to excite us to continue. We are interested, however, in any

other narcotic antagonists

which can be of longer duration of

action and with fewer side effects.
I am

enciosing copies of our reports which wiii bring you

up—to-date in our present program.
.

In the event that SOSO-M, or other active antagonists
goes to human triai, we wouid be anxious to test it.

Sincerely yours,

~_v,ww..wnv,_

Fink, M.D.
Professor of Psychiatry

Max

mmﬂwmuvm.mwﬁlwvmww

.m

.
.~

Mszp

v—

m

W»

W

~

.

�</text>
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                    <text>September 3, 1970
Dr. G. F. Blane

Clinical Research Co-Ordinator
Benson Lane

Hull, England
Dear Dr. Blane:
we

would

studies of

your copy

like to continue our exploration of antagonists

M5050.

I have

is enclosed.

by

obtained an import permit (#2533) and

Can you make a small supply

available?

available a description of the completed animal
toxicology, and a description of the fbrmula, chemical synthesis (in
narrative outline or literature references), address of site of
preparation, and a copy of labelling data. I will need these for
the U.S, F.D.A. to file an IND.
I trust these are the next steps, and would like to proceed.
Can you make

You

will note that the permit lists

M99

be ignored.
Many

use of

thanks for your cooperation.

this interesting

compound.

as well -

this is to

I hepe we can make some

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
611C 0

clinical

�</text>
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                    <text>October 20, 1971
Dr. G. F. Blane

Reckitt

&amp;

Colman

Danson Lane
Hull, England
Dear Gary,

is our application (finally) for support for
research. I an optimistic that this will gain approval,
particularly since my government is showing special interest in
the narcotic antagonists.
I have received the note regarding change in shipment
route for M—99. I called our BNDD and am assured approval
has been sent to the British Home office and to Reckitt
Enclosed

MrSOSO

and Colman.

I enjoyed meeting Dr. Lewis. You may tell him there have
been additional meetings of the FHA Committee on treatment; and
NIMH has appointed a select committee to
plan research in the
antagonists. Its first meeting is October 28.
Thanks again

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>September 7, l97l

Dr. G.F. Blane
G.F. BLANE, RECKITT
Pull, England

&amp; COLMAN

Dear Gerry:

Enclosed is a U.S. import permit #3252 for the
1

tnﬂlsfer of

official

of Etorphine. I would appreciate your
sending copies of the available reports on the human use of
Etorphine, and as much of Etorphine as you can make available.
,

I have

gm.

Just returned

from Europe and will be

the

attending
meetings in Washington on narcotic antagonists on September 9.
Many thanks for your cooperation.
Sincerely yours,
Max

MF/rs

Fink,

M.D.

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                    <text>Docsabsr 6, 1971

Dr. Garry F. Blane

Rsckitt &amp; Col-an
Hull , England
Dear Garry:

Ho bass rscsived the supply of storphins.
undsrtaks our studies rapidly; many thanks.

We

will

Thsrs is much enthusiasm for an sscslation of rssaarch
in the narcotic antagonists. Ha hsvs, this vast racsivsd a supply
of naloxons psaosts for study; and l~cyclasocins is now in suffi—
cient supply for human trials bsginning next south. I an opti—
aistic that we will obtain funds for toxicology, sufficient to

file

an IHD.

Again, sy thanks for your hslp.

Sincsrsly yours,
ﬂax Fink, M.D.

Professor of Psychiatry

3311;

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                    <text>-.

-.-‘-.w7.-..,w-—.....u.n. :mwt ,~~

V

«mvmyvml «smwuw-r-mwugmu-z m.
-

-»

"h‘w‘r‘ _

..

ya“

_,

namwv

.

w»

I. in?

ww— --

~

~~«..~n,w.-

0-6! “New“...

._

~...-

u r.

w".

.

w,

w"...

m

mm

“a“:

w‘III-rvvnx-q'lmvv

-—‘.

I”
.

,

vm-rwmwmm.

"hwy..-

,

'1‘ﬂrw¥~"'wnr'"'W:-—

m1

n
r
v

January 24, 1972
G.

F. Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Cary,

The Lord

preserve us from.the enthusiasms of childred

!

Your letter about the M5050 situation was most welcome, but
the situation is murky, confused, disorganized, and typically American—during the War, we described the situation as SNAFU.
To recapituiite: our laboratory became interested
in the antagonists in 1967. We heard of diprenorphine and contacted you,
as well as Lederle. They were uninterested~~ you and we were. We proposed
a study of the animal toxicology, peior to obtaining an IND to assess its
activity in man. We requested funds of the New York State Commission,
but were denied. We tried NIbiB, the Cityoof New York, and private donors-~

and each

felt that

such

trials

were the expense of

industry.

tried Nlhi,

and they were receptive, and.
Meanwhile, the White House
appointed a brash, young man to h.ead its program; and he asked for assistance
from other brash young men, without experience. Nevertheless, when they
called me some weeks ago, I shared the full file with them, for
is
irrelevant to me who provides the support for the animal work. They
called to ask how much material I had, how much would be nodded, etc. I
answered, openly, and offered the material in hand to start, and indicated
that I would write you for additional material as needed.

Last

summer, we

hence the application which you read.

it

last week, Dr. Green told me that he had assumed full
the program; that he had called you; that there were
for
responsibility
the usual bureaucratic complications of the precedence of a U.S. grant to
do the work of industry, and who would get the rights if the material was
successful, etc. I suggested he review the massive contracts between the
military and industry, and that he disregard the trivial amounts necessary
heae. But, he indicated, that I did not understand his many problems, etc.
Then,

MIME has indicated that they will fund the grant
of
first April; and the City of New York has indicated that they
fund
animal trials, if I guarantee that we would have enough
the
will
do
the clinical work thereafter (which I did); and Drs. Green,
material to

about the

Meanwhile,

Jaffe, et al. are

runnung about.

.

.

.

,

�..

v

w

'7- '

~,

-

»

-«

'vnwrr

Jr

u'vhb-J'vvn'rr.

,.

'

n1”:

,

_

x

A

,

wv'ip::—

. .
”7"1'30'.N‘W‘F="|"'Y:'XKW»

.. ,,

.7

,.'mriwlwﬂ‘wmﬁl—(wé-WNWﬂW'thWH‘.

_

‘nr—I‘»

».\

My reaction is similar to what it was last summer—- to take
holidays. I am off to Greece for the week, and hopefully, the various
competing agencies will resolve their problems.

some

Our position is what it was two years ago-- we are prepared
interested in establishing the clinical efficacy, dosage range,
toxicity, utility, and anything else that may be interesting of the antagonists
in opiate dependent subjects. We are now embarked on essays of naloxone

and

pamoate; have been promised l-cyclazocine next month; and

BC

2605

in

Should some agency probide the basis for an IND, we will do
what we can-- and hopefully, R 8 C will make some material available
for our studies at that time. Or, should I husband my present supply,
and let MIME, Green and Jaffe, and New York City obtain their supplies
from you ?

April.

Incidentally, in the usual disorganization of our governement,
will probably get out funds, eben if the toxicity is done at the
military centers in the v.3.

we

I look forward to meeting John Lewis again. There may be

error, however, for I believe the Drug Dependence meetings are
to be held in the late Spring in Ann erbor and not in February-— unless

some

he

is

coming to a committee meeting and

scientists in the field.

that is not

open to the

Keep weal, and do what you must to secure your compound's
study. While I would like to be its monitor, I do not see how I can ask
us are brash, and unSOphisticated, and tend
it, for the forces aboutwherever
and whenever they can.
to assert their powers

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mm

.4.‘

w..-

.
4.,

amyyrcwm-w.au-awm-

'n'

v-um

.

.7...“

”WA

5.-

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"'rr‘

�</text>
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                    <text>Juno 20, 1972

G.

F. Blane, Ph.ﬂ.

Reckitt &amp; Colman
Hull, England
Dear Gary:

Enclosed

is

an

official

U.S. import permit #3349

diprunorphine, for our annual assays.
Thank you

for

for your cooperation.
Sincerely yours,
Max

Fink, d.D.

Profnssor of Psychiatry

3F:1g
Enc-

’

15 grams

�</text>
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                    <text>28
G.

April

1972

F. Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Gary,

Thank you

for your letter of April

7.

have entered into a contract with Woodard Laboratories.
their work with the 10 grams diprenorphine you sent me,
and earlier this week called to say that the material is sufficiently
non~toxic that, to meet the FDA requirements, they may require an
additional 15 grams for toxicity studies.
We

They have begun

I called Dr. John King, as your letter indicated (I had
not heard from Dr. Kiltie or Dr. King) and when I broached the subject,
he said that he would call me back that day with some answer. He
did not call back.
Since the White House has entered into negotiations with
Lederle and with yourselves, it is clear that our original understanding
(that of supplies from Hull) is no longer valid.

I have indicated to Dr. Jerome Jaffe that, in the face of
office he holds, I can do no more than wait patiently for
some resolution. The present studies will end within the next fortnight,
lacking additional supplies.
C'est la vie !
the

awesome

my

best regards.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

�</text>
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.mw

——.———..__..m

W.—

...

w—w-p—

—._.—.w

August 21, 1972

Gareth Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Gary,

for the supply of diprenorphine (M—SOSO),
arrived this morning; and I which I immediately
delivered to Dr. WOodard in Virginia, who is carrying out the
Thank you

15 grams, which

pharmacology

trials.

anticipated, the National Institute of Mental
Health and the special office in the White House have announced
the organization of a number of contracts for the clinical evaluation
of narcotic antagonists. The amount announced was $2 million, and this
sum includes some funds for periodic meetings on the subject of
As we

antagonists.

present schedule at Woodard provides for the completion
of the studies by the end of the year; and we should be prepared to
undertake clinical trials soon thereafter.
The

My

thanks for your help in providing

this material.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
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    </tagContainer>
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</itemContainer>
