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                    <text>April

25 , 1967

Dr. Nocmettin Polvan
Cod. Bumn Apt. 17/1Taksim - Talimbane
Istanbul, Int-key

Win

Dear Dr. Polvan:

'Ihmnhasahamdwithmtmmportsofpmgmssintm
I an very phased that this collaboration
lagoingoomll. ‘l'umntellmetMtheiaplmnjngtovisit

butapomzine study and

ymwlyinﬂayandlmpeﬂutlwillraveanoppmity
tovisitdtmingﬂmesunner.

mcloscd is the proposed protocol which we have worked
out for a accord study, that of high and very high dose
fluprnnazine. It wmld be helpful if you mold critique
this proposal and discuaa'it in detail with mom when he

meets with you.

Also,

extended to
When he was

let me

‘

thank you for any camtesiea you may have
chel. I hope be contacted you

friend Joanna
in Istanbul last

my

week.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

ale.
cc:

Ir. Itil

�</text>
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                    <text>April

11 , 1967

Dr. Necnettin Polvan
Lamartin Cad. Burun Apt. 17/1
Taksim - Talimhane

Istanbul, Turkey

Dear Dr. Polvan:
This will introduce Mr. and'Mrs. Joshua Vogel who are
close friends and are visiting Istanbul as part of a tour
of
the Near East. Mr. Vogel is a lawyer who has become interested
in my psydwpharmacology program and is intrigued by the
collaborative idea.

I have asked these friends to call on ybu in the hope that
to provide them with some introduction to the
interesting sights of Istanbul. Mr. Vogel just told me two
days ago of his planned trip to the Near East and I enoomeged
him to visit Istanm1, which Was of such great interest to
us.
you may be able

“Duran has told me of the initial observations in the
butaperazine study and I am very interested. It is exciting

to participate in this collaborative effort and I hope that
there will be an opportunity this sumner to cane to Istanbul
with
a

Turan.

Incidentally, 'mr'an did share with

month ago resending your
Thank you very much

Mr. Vogel.
My

visit

here.

Are you

for any courtesies

a question
plaming to cane?

me

you may extend

best personnel regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
M'r":kp

to

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                    <text>a,“ WP

.W
.

._

‘

'

.,

..

,‘_VW‘W.\.‘v.-mem‘7”my ..mum:..Mum—v
V

——

-»--" I

May

'

,

vvd-n,
»

V“ 1*3'""‘vv-n'mn’w’u:JV” HI'H'T‘FWPVW-W'Wr7‘70”"

214

W"v""" """r'ﬂ

"V "

, 1957

Nemttin Polvan
Taksim - Talimhane
Dr.

Lanartin Cad. Bumn Apt. 17/].

Istanbul,

Dear

Dar.

My

1°0le:

Imgladﬁmt'fhmnlushadacmmetometwithyou

*3

about the project and nape that the first study is naming
well. I am enclosing copies of the fluphenazine protocol
as revised by yetme and Dr. Itil.

1am;

Sincerely yams ,

76’

Mr

n
m“-

fiv.&amp;‘2'¥§;)‘?ﬂ5¢"llr‘

Max

Pink,

PM).

meesaor of Psychiatry

.»L~zu«r

HPﬁq)

"""'"" m-vr,

�</text>
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                    <text>“WNW

errr mm. y-mu»..mn-r~

ammunmmw-mrv-nm-v‘v.m4”

wry-Tww'WI-i-ww..uitmﬁw‘w

'm’w—a

:m

.

.

.

ﬁrm."I-

December 29, l967

Br. Necmettin Polvan

Abuulhak Hamid Cad. 76/4 Serin Apt.

lalimhane, Istanbul

Turkey

near Gr. Polvan;
Your recent letter about the fluphenazine and butaperazine
studies was most welcome. Turan has told me of the data from the
butaperazine study and I look forward to reviewing this with him
on my next visit to St. Louis.

pleased that the concentrated flunhenazine arrived and
found
useful. This supply was specially prepared for
that you
have
we
and
usﬁ
requested a large clinical supply be made available
as soon as practicable. The laboratories in New York have agreed
to supply us with a large quantity and they are proceeaino with
production rapidly. Additional supplies will he sent as soon as
I am

it

they are produced here.

Turan has suggested that I visit Istanbul on my next trip to
Europe. I have already made plans to be in Switzerland during
the period February l0 - 24. I would like to visit Istanbul during
the last week of February, arriving February 28 or 29. I will have
a more definite itinerary late in January.
Will you be in Istanbul during
to visiting you then.
My

best wishes for

that

week?

a Prosperous and Happy

May I
New

look forward

Year!

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

NF :

kp

‘
-.

a.
-,.
.r
i:

ri-i.;.;;4_g;..

.n‘

o
a.
gag;

2r...
—‘

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                    <text>March 4. l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad. 76/4 Serin Apt.
Taksim ~ Taliehane
Istanbul, Turkey
Dear Dr. Polvan:
You know that I enjoyed my visit to Istanbul
very much.
Your hospitality and that of your associates was overwhelming.
But most important, I was enthusiastic about the
progress of
the fluphenazine and butaperazine.studies.

return, I found your letter requesting some medical
supplies from the United States. I regret that I had not
received this before I left for I would surely have complied.
Please excuse me.
On my

Dr. Itil about the studies and have
plan to meet earlier in the week of the GIMP
meetings to write the report for presentation. I have told
him of the tables 1 suggested and I am sure that he
will write
to you either confirming or changing the outline.
I have

written to

suggested that

we

I look forward to seeing Miss Guven in New York

early this
yourself in the fall. Please extend my best personal
regards to Drs. Ziyalar. Yagcioglu and Songar for their courtesy

summer and

and patience during my

visit.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>February 7, l968
Dr. Necmettin Polvan
Abdulhak Hamid Cad 76/4

Serin Apt.
Taksim, Istanbul
Turkey

Dear Dr. Polvan:
Dr. Itil has written, I am planning to visit Istanbul
end
of February. My present plans are to leave Zurich
at the
on Swiss Air 326 on Sunday, February 25. The flight is scheduled
As

to arrive in Istanbul at 7:05
Dr.

grateful

pm.

Itil suggests that I stay at the Divan and I would be
if you would call them and make a reservation on my

Failing that, I would trust you to
at any hotel convenient for you.

behalf.

As I

understand my mission.

it

make a

reservation

is to see the patients with

you on high dose fluphenazine; to review the butaperazine project;
and to visit your hoSpital and, if possible, the Bakirkﬁy in

order to maintain our relationship with that institution.

this trip I would like to visit the laboratory of
Professor Roubicek in Prague and have scheduled a flight
from Istanbul to Prague on February 28.
On

I look forward

best regards.

to seeing you at the end of the month.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

My

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                    <text>September 11, 1966

Dr. 023%: Polvan

.c/o Profossor

N. Polvnn

Department of Houropaychiotry
University of Istanbul

Istaohnl.

Tutkoy

'

Dear Dr. Polvan:

to take this opportunity to thank you for your tour of
Istanbul and your excellent translation of my report. Before
I left I had broaktast with Dr. 56mm: and he confirmed that
you had done a vary good job. Many thanks.

I

want

I

am

enclosing a number of reprints of my work in ECT and son:
of the more recent articles on drugs. I hope these interest
you and I wish you the boat of luck in your study programs.
Sincerely_yours.
Fink,
Dirootor

Max

Hiljb

M.D.

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"m...

February 20, 1987

Wmuuwlwmm'wmww,

Paul 3. Poppers, Md).
Professor 6: Chairman
Department of Anesthesiology

at Stony Brook
Long Island, New York H791;

SUNY

Dear Paul,
1 am pleased to submit this letter endorsing the promotion of KENNETH
FREESE, MD. to the rank of Clinical Associate Professor of Anesthesiology.
1 first met Ken when he delivered anesthesia for the ECT service in 193$.
At the time, we were studying the relations between seizure duration and outcome.
Ken was particularly remonsive to our needs for Controlled anesthesia. Later, when
i decided to edit the journal Convulsive Therapy, I raised questions with him, which
he answered with good documentation. One response led to the report "Can

patients safely undergo electroconvulsive therapy while receiving monoamine
oxidase inhibitors?", which 1 published in 1985.

A

v"

w—rryu—n-vvv

um—w-

Wu‘mmvH—m

"‘WVHWv—rtwm'w

Aww‘zmv‘w—‘m

Last year, i invited him to discuss the relations between anesthesiologists
and electrotherapists in the American Psychiatric Association training course on
*1 ECT in Washington. His presentation was authoritative and stimulating; the
students loved it. His success led us to invite him to present again in May this year
in Chicago.
Since he took over the chair at the Nassau County Medical Center, we have
met occasionally, to discuss our common interests. He has maintained his interest
and enthusiasm for this special application of modern anesthesia.
Ken is a most engaging, enthusiastic, responsible, and competent physician.
He is an excellent student and teacher. He aroused in his residents (and in mine) an
interest in anesthesia, and encouraged their understanding of the physiology of the
processes. His administrative skills are excellent, and are reflected in his being
selected to take over the arduous position at NCMC. I am pleased to recommend
his promotion, and do so with enthusiasm.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry"

'

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                    <text>March 26, 19 88

Professor Paul J. Poppers, M.D.
Department of Anesthesiology

at Stony Brook
Long Island, New York 1.1794

SUNY

Dear Paul,
I am pleased to submit this letter in support of the promotion of Dr.
FARROKH R. MENEKSHA from the rank of Clinical Assistant Professor of
Anesthesiology to Clinical Associate Professor. 1 have worked often with him in the
ECT treatment unit. I first met him during his residency training, and since then he
has frequently been the attending anesthesiologist for our treatments. It may be
useful at this point to indicate that our ECT facility is a tertiary care center, with
many high-risk patients sent to us from other treatment facilities for this complex

treatment.

He is a dedicated and responsible clinician, well trained with a sincere

interest in our patients. He shows good clinical judgement, relates well to patients,
and is well liked by the psychiatric staff. Regardless of the medical and anesthesia

complexity of the case, he has been deliberate, careful, and reasoned in our
collaboration. He has a knowledge of a wide range of interventions, and l have yet
to see him upset by a case.

He is well versed in the anesthesia literature and discusses the treatment
with assurance. His knowledge of anesthesiology appears excellent, and he likes to
teach. He is comfortable teaching both anesthesia and psychiatric residents and

students.

Farrokh has been interested in our research studies, and he has been most
cooperative regardless of the delays which our tests and requests imposed on the
clinical process.
Finally, Farrokh is friendly, relaxed, interested, and enthusiastic about our
work. Given encouragement, I believe he will expand his research accomplishments.
He is a valuable member of the clinical staff, and lam delighted to recommend his

promotion to associate professorial rank.

This letter may be shared with him.
Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>7hSB-l22SB
May

J. Silvio, M. D.
National Institute of
Rockwell Building

10, 197h

Drug Abuse

llho Rockville Pike
Rockville, Maryland 20852
Silvio:

Dear Dr.

Enclosed is a formal report of the studies completed at
Hospital, Northport, under contract HEM h2-73-260 during the
first quarter of the year.

VA

While we have obtained the support of the local staff at the
Hospital and have a fine facility, VACO has decided to end the
DDTC funding on December 31, 197h. They have indicated they will
provide a decrease in the budget fer the second half of l97h and none
fer 1975. This support is the mainstay of our program and we cannot
sustain our effbrts without it.

VA

With the funds remaining in the contract, we can sustain the
project through the third quarter of the year, provide followuup for
some patients during the fourth quarter with an orderly termination
of personnel and transfer of patients to other treatments with the
present termination date of the contract.

Unless the present circumstances change, we will be unable
to participate in this interesting and imyortant study program beyond
the present contract period.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure
cc:

3. Yolles, M.D., H30
8. Kieffer, M.D., KSC

D.A. Swanson, M.D., VAR
Brissendin, M.D., VAH

A.
M.

Knahner, M.D.,Dean,

HSC

�</text>
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                    <text>,

—_

“.77... m:

.

,N—

n-

,

nun-m7. y

‘

7m“... "w.

“‘

WWW -lnnanpwuwwqua—warm

March
Mr.

Porlo

New

York,

Chief U. S. Chemisf
64| Washingfon Sireef,

|

New

York

Room

.

’17-“

-

W‘s—w

~_-

~

..

”ﬂung—w...

l3, i969

l003

Dear Mr. Porlo:

Following my discussion wllh Mr. Tagley of The
Federal Bureau of Narcotics, i am enclosing +wo samples
of presumed narcotic subsfances confiscaled from paiienls
admiffed to our deparfmenf during The pasf monfh. i
would appreclale an analysis for oplaTe subsfances (heroin).
We have been Told ihaT lhe malarial may haVe been cu? wifh

procaine.

Sample

capsule.

3/l is

in

silver foil; sample 3/8 is

in whife

Sincerely yours,
Fink, M.D.
Professor of Psychlalry

Max

Mszp

�</text>
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                    <text>July 1,

1964

Miroelav Posedel, H.D.
3950 Kelsey Place
Colombia 4, Ohio

Dear Dr. Posedel:

for your inquiry. The Missouri Institute of
Psychiatry is the research and training center of the Division of
Mental Diseases of Missouri. It was established in October, 1962,
with laboratories and clinicsl facilities for research. At the
present time, of 150 beds, we are utilising 70 for research pur—
poses. Laboratories are established in pharmacology, psychology,
and electroencephalography. as well as a computer center for both
Thank you very much

statistical and BBC analyses. There is a specialised psychiatric
reseerch library as a component pert of the Institute. Animal
facilities are now being built and will be completed by the end of
the year.

there are a number of research programs in
progress. These include Lithium as e therapy for mania; the use
of Yohiubine an a precipitant of snxiety and the deveIOpment of
anti-anxiety agents; relation of EEG patterns and organic factors
in the treatment of therapy resistant psychotics; computer analysis

At the_present time,

of the electroencephalogram; the effects of drug withdrawal on
behavior in the chronically ill; the evaluation of new psychotrOpic
drugs is part of a national early clinical drug evaluation program.

.c‘

..v.‘--.,.oq-,~.

.

In neurophysiology, we have the following major programs: evaluating
the 330 changes with psychotropic drugs and relating these to the
behavioral results; a study of the cortical averaged evoked potential
and determining the stability of this method in our patients; and in
determining the interrelationship between different methods of EEG
analysis and efforts to quantify these, and to relate these changes
to behavioral changes as reflected in psycholinguistic methods.

m,—

awdqfw

wiw

At the

present time. the Institute is planning to expend these pro~
We are inviting the collaboration of scient-

stems in the coming year.

ists

whose

intereste are compatible to our

tunity such as this institute provides.
applications.

.
..

A

"mas-Farmy—

own and who wish on oppor~
and are pleased to consider

�Miroslav Poocdal. H.D.
7-1—64
Tho

Pas:

I

uuuld apyrnclata a copy_o£ your curriculum vitae. listing
chronologically your .ducatlonal and professional experience.
In addition. a small photograph and thc n1mea cf at least two
rcferuas to whan us may write would be moat helpful.

Sincercly youro,
Mu Pink, Md).
Dirnctor
luv/1b

�</text>
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                    <text>Robert M. Post, M.D.
NIMH
Building 10 Room 3N212
9000 Rockville Pike
Bethesda, MD 20892

May 21, 1996

Dear Bob,
I am pleased to nominate Harold Sackeim of Columbia University for the

NARSAD Selo Prize.

For the past decade, Harold has been the nation’s leading researcher into
the practical issues in electroconvulsive therapy. He has deﬁned the importance of the
seizure threshold, energy dosing, and electrode placement in the eﬂicacy of ECT for
affective illness. In addition, he has clariﬁed the role of ‘pharmacotherapy-resistance’ in
the efficacy of ECT in affective disorders. Leading from those experiences, he has
organized and is now analyzing the data of the nation’s only study assessing the relative
efﬁcacy of continuation TCA vs continuation lithium plus TCA vs placebo in the aftercare
of patients who complete ECT. He has also made important suggestions as to the
mechanism of action of ECT, and in the present brouhaha about TMS, he is carrying out
the most organized and detailed studies of this possible alternative induction method.
He has been an NIMH scholar, a NARSAD scholar, received an award of
the ACNP, and is now a member of the APA Task Force on ECT.
For the decades of the 19605 to the 19803, it could be said that I led the
ECT research community. In the past decade, that role has surely been taken by Harold
and his leadership should be acknowledged. I am pleased to nominate him for the honor.
My best regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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Dear Mr. Poterba,

I regret that my schedule of appointments made it
you in person for your thoughtfulness in making
a drug administration kit available for this laboratory. It is
a useful addition to our facilities, and I thank you for your con-

difficult to thank

sideration.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>February

9,

1967

Mr. Alexander M. Peter-be
39 Cedarlewn Blvd.

Valley Stream,

New

York 11580

Dear Mr. Poterba:

for the copy of Wittenbom‘s book
Clinical Psychoplumacology of Anxiety." I have read
this during the past few days and found it met interesting.
The date he presents is highly sophisticated and provides
some of the more rigorous data in our field.
"The

Thank you very much

Thank you

for yew courtesy.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MFsz

�</text>
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                    <text>May 23, 1984

Steven G. Potkin, MD.
Department of Psychiatry
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20857
Dear Dr. Potkin,
was interested in your presentation at the Society of Biological
Los Angeles on the continued use of insulin coma in China. My own
in
Psychiatry
l

contribution to the insulin coma story was to carry out a random assignment,
insulin coma gs chlorpromazine study at Hillside Hospital in New York in 19571958. This was published under the title "Comparative Study of Chlorpromazine and
Insulin Coma in the Therapy of Psychosis ( JAMA _l_§_6_: 1806—1850, 1958).
The enclosed Chinese paper reports on 2,858 cases of psychoses treated
with ECT, and send it on, as requested. If you can translate the data tables, I would
be most interested in the findings. The citation list of ﬁve papers is for reports
between 1950 and 1960 only. Do they not get any Western books or journals? Is
that a reason for the continued use of insulin coma?

thanks for an interesting paper. I would be grateful to receive any
reports that may come from your experience with insulin coma (and ECT, should
My

you get back there again.)
My regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>July 21,

1965

Potter
5. Sterling Gummy

Mr. Tom

7849 North lindbergh Blvd.

St. Louis.

Hismi

Doarﬁr. Patton

Hymociates mdlwwldliketogoalnaduiththeexdxmge
I'll—1300 tow a 7
313.300 with four additional moon}!
mpmm militia-a. m tmslatim of ow present family of

m1

of an

100, fmm mama mime to $19400
y
matibloismquimd,andasmaathedetailoofﬂuemmnga

up»,

&gt;

H

mmhted.mwillmkmtatmfarofthesetmstoyw
hbomtorics for we): tummion.

We

is a signed mquiaitim
masonry stop in this
of Missmri, which W is tedmioally tho
of the £34800 . Attmd is a purdwoe order oopy which
has just been submitted to tho University for their acceptance.
The Wmity will bear no mmmility for the additional
clauses new: in your lotto» of July 2, 1965. These additimal
chars” ($3,825) will be paid by the Psychiatric Round:
Pamdatim of Missouri. This omtmot mktimship of the
A

m

from the University

Pamdatim is contingent

«new.

As soon

upon

the unwmity'a

mm the

as tho University has signs! the requisition, I

shall omtact you again.

Sincerely yours ,
ﬂax Fink, NJ).

Professor of Psychiatry

8?sz
one.

�</text>
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                    <text>May

2. 1966

W].
Indistxy Maegan - Medical.

Mr. F- A.
IBM

'

_

112 {Last Post Mad

mite Plains,

New

York 10601,

Dean Hr. Powell:

for ycur lettnn of April 22, 1966.
fact that I will he mlccating in New Yam, I
taupe that the ccllabomtion begun have with Dr. Donald Shapim
(who is reheating at Washington mimity) will permit us
to
a suitable demonstration in 1967.
Thank you vary much

Danpita the

m

mthmeklhcwtmmgotiatingwithtm

mpnaaantativcs in Na: York mending the pcsaibility cf
«obtaining a 1711 and 179% frmt and cumin: fan the presently
available IBM 1620 pmsaor M: 1:11. New York
College.
I have emphasized to the local representatives that the
availability of such aquipmnt will maka ponsibla the ccntinmticn
of the ewlomticna which was have begun in St. Louis withut
the nccaaaity of axpenaivc and time cumming mpmgmwing.
IBM

mm

As

IwillbetmnafaningmcfnyatudicstonYczk.

and since: the (18%

is

suppontmg this pnognm for conputcn

services at a amthly rate of approximately $1100 for aquipmmt
that a continuation
mxtal. I believe that I could mince
of this program in ﬂaw York at appmximtely the same rate
muldbea lcgicalcmﬂitm of funds. While itwouldbc

m

W

vazymasmabletomqmatsuppcnt fwafullunitcfanIBH
1800, I do mt helluva that our study
in extensive
such a facility fun a single user. Rather,
enough to
1' believc we can contribute heavily
to tha {mammal from New
York Madical College for an IBM 360 System. Weaver, this is
sanctum in the film, and I an writing to tell you these
details became in my diamaaion with the IBM mpmamrtativa,
Hr. Robert Shannan, he indicated that my present suggestion
for such an upW‘wwld be difficult to achieve and thought
hemﬂdcalltoankycm'advicc. Imuldbamtaful fonany
asaistm that you could give him.
I will be in touch with you late in the Fall.

Wt

‘

Sincemly your-s,
Fink. Mal)Professor of Psychiatry

MEX

mnjmh

�</text>
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                    <text>E
February 7, 1972

Dr. Juan de Dios Pozo-Olano
21 Webber Avenue
Bedford, Massachusetts 01730
Dear Dr. Pozo~01anoz

Neither of the articles you requested are available.
Psychiatric Research Foundation of Missouri, Publication No. 65—
10 was a preliminary report of our EEG
sleep classification studies,
and was recently much elaborated and published in EEG Clinica£ Meadophyéia£.,,27= 76—83, 1969.
—

Psychiatric Research Foundation of Missouri, Publication

No. 66—1, a manual

and no copies are

prepared by Shapiro and myself, is out of print

available.

I have not yet seen your report on computer studies of
brain waves, but would be most interested in sharing a copy with
my associates.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:ig

�</text>
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                  <elementText elementTextId="105013">
                    <text>February

9

, 1966

Wt Mom

meessor 8.
0011.3.

How/mm

01'

of

Humming

Lhiversity

Hakim,
Dear

N. Frames:

9.0.

meessm

20001

Wm:

”Antimonumforﬂnmhmm
magmas was computed: 1’st ago. Myeo—spmsor,
format?

Hallueimgam"

m.3rwloyhubmwaym1hmyattomceiveamdmim
ﬁmhiumgardingﬁnpooaibmtyofalteringﬁnpmgm.

Imuldbaimmudinmivhganabsmct
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1970

2

Praha, 1, Czechoslovakia

Ref: Matejkova
CINP

Gentlemen:

Tour # 66

I am in receipt of your letter of 8 July confirming
double rooms with bath at Parkhotel. Enclosed is prepayment in the
requested amount of $ 192, our check # 543.
2

August 10

arriving at

I ask that the reservation arrival be changed to
are arriving from Amsterdam on KL 281 on August 10,

May

? We

1025.

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>March 28, l968

Dr. Arthur

J. Prange. Jr.

Department of Psychiatry

University of North Carolina
School of Medicine
Chapel Hill, north Caroline
Dear Dr. Prange:

for your paper “Enhancement of Imipremine
by
Thyroid Hormone." I have read this
Antidepressant Activity
with interest and can find little that I can criticize. The date
Thank you very much

is impressive.

may be of some help, and personal interest, to read
some of your other reports. notably Nos. 55,and 64.
of
copies
If these are available, I would appreciate the opportunity to
read them before the meeting.

It

I look forward

to seeing you in Boston.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>March 28, l968

J. Prange, Jr.
Department of Psychiatry
Dr. Arthur

University of North Carolina
School of Medicine
Chapel Hill, North Carolina
Dear Dr. Prange:

Thank you very much for your paper "Enhancement of Imipromine
Antidepressant Activity by Thyroid Hormone." I have read this
with interest and can find little that I can criticize. The data
is impressive.

It may be of some help, and personal interest, to read
copies of some of your other reports. notably Nos. 55.and 64.
If these are available, I would appreciate the opportunity to
read them before the meeting.
I look forward

to seeing you in Boston.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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V

.-.,.«-w~-w.-W-~-r~r‘w1-m‘m.u.m.m“mm-7.." .u—v—wnvun .vuun u...» w—z—W~

..

,

.,,.,.,_,.

. m."—

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.w.

u.

7

,

,...

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1
,

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April 17. 1969

war-r

Dr. E.

A

atix:3':ximmm‘

m

.n‘GWWZ-w‘w‘wu

\W.txw”‘vw.'v

\‘W‘.7

I“.

J. Preston

A. H. Robins Company
1407 Cummings Drive

Richmond, Virginia

Dear Dr. Preston:

Re:

Tybatran Laboratory

for not submitting the enclosed data
when
earlier. but the data has been misplaced until this week
additional
the
Enclosed
I reviewed our fenfluramine data.
are
records of laboratory tests in narcotic addicts assigned to
Tybatran treatment. The data filed earlier was that available
in patients who sustained treatment. Each of the patients in
I must apologize

the present group withdrew from treatment before repeated
laboratory tests were completed.

W?

Please add these records to those filed

r;

earlier.

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

.

.

ﬂ

,

�</text>
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waW—'.

rmmwvnw

July 27, 1%?
Mr. Lester W.‘ Preston,
A. H. Robins Company
11407

Wings

Rid’umnd,

Drive

Virginia

Jr.

23220

Dear Mr. Preston:
Enclosed am.1:he publications which you requested during
the meant visit to cur laboratwy. We are mast grateful for
your interest and your help in the EEG study.
.

Sincerely yours
ﬂax Pink, M.D.

.,

Professor of Psychiatry

MP:kp

&lt;

'ﬁ'r-n-qm-r

v-r

,

'.

war,

.

'

�</text>
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                    <text>~,

9.»... ,n

..

.—

_..,.W_.W“ . W “m- .m-w~_
,r

V

..

.vm..-

,..

.

.

a“, ”.7. .7 Va.

mw—

'—

72'.
v

#1) 4

&lt;-———v

-—

«w

mv—"-vmﬁu’llr

er—vvwrv-r‘vv

.r—

.

March 1, 1982
w-w_.y..~_wv_..—_r

Mr. C. Prettyman

.

Ail,_“w,wm.

Division of Neuropharmacological Products
FDA
5600 Fishers Lane
Rockville, Maryland 20857

Ref:

A'WHNWW

”WV

- Mianserin

Dear Sir:
The following is in response to your inquiry of February 24, 1982.

-m&lt;wmt=-mV—nwww"7

""1"“

1ND 17,365

in 1981, five TCA non-responding patients were inducted to courses of
mianserin. The first two patients began their treatment as in—patients at University
Hospital. Doses ranged from 20 to 160 rag/day in one patient, and 20 to 60 mg in
the second. Their clinical response was not outstanding and both went on to receive
successful courses of ECT.

Three patients received mianserin as outpatients, with doses of 20 to
nag/day. In one, the response was considered very satisfactory and the
treatment was discontinued on 2/ 15/82. In two others, the results were not
one was readmitted to a chronic hospital and the second was
outstanding
successfully treated with ECT.
120

-

Two patients have been inducted in 1982 and are now doing well under

treatment at maximum dosages of

120 mg/day.

In none of the live completed patients (and in neither of the two in
progress) have we recorded any untoward effects of the medication at these
dosages, either in the self reports, observations, or laboratory tests.
I

trust that this information is useful.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>73AP~771AP

16 November 1973

Joseph Zubin. Ph.D.
Chief of Psychiatric Reeearch (Biometrics)
State of How York Department of Mental Hygiene
772 West 168 Street
new York. New York 10032

Dear Joe:

I

am

delighted that the voluna Contemporary Sexual Behavior

in in such demand. Your optimism in reprinting 2000 additional
copies is commondeble and. onee egein. I think your vision has

been substantiated.

I called Milt Greenblatt and was satisfied that the Com~
mittee had made an appropriate recomnendation with regard to
Philip May. A copy of Milt's note to we is enclosed, and I
believe that the View expreeeed in this letter abould be made
a aetter of APPA record. I plan to raise this in the discus—
sion at the next Council-aeeting.
Again.

voluae.

my

congratulations on the success of the "eex"
Sincerely yours.
M“ Fink,

MF/cie

he}. 0

Md).

�</text>
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                    <text>August 28 1997
Dr. Valdir Pricoli
Rua Albilio Soares, 639-123
04005-002 Sao Paolo
Brazil

Dear Dr. Pricoli,
Thank you for your letter. I am pleased to have been of help.
I am moving my teachiong and research operations from SUNY at Stony

Brook to the Long Island Jewish-Hillside Hospital complex in Glen Oaks, Long Island. It
is closer to the city. The hospital has a long tradition of ECT research -— back to 1953 -and I have developed a research team there.
We would be pleased to have you visit. Arrangements can be made to stay in
Great Neck, about 10 minutes from the hospital, or in New York City —- about 30
minutes.
You can reach me at my ofﬁce address as on this letterhead.
My regards.
Sincerely yours,

Max Fink, M.D.

�</text>
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                    <text>Dacrmlmr

1).".

1N

, 1965

Robert F. Prim

Project Coordinator
Biometric laboratory

The Georg: Washington University
Room 618
11%
Stunt, NM.

241th

‘

Washington 6, 13.0.
Dear Bab:

for the list of study patients at
We will analyze the initial set
efdatatodatemdmifﬁnmupammmblemto
their ass characteristics. We will soled: various items
from the EEG analysis and than arrange for multiple discriminant
Thank you wary mach

War:

State Hospital.

analyses.

'mmk you for your cooperation.
Sincerely yours ,
Max

Pink,

PM).

Professor of Psychiatry

”(P

�</text>
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                    <text>Dr. Rabat-t A.

Priest

Hammer 15, 1963
Page

'I‘wo

.,

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mu.

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within tin
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established policy of the Imtituu
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                    <text>Fohmuy 23, 1966

Primntm Applied March Corp.
Dapt- 3
Box 565

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300w of bulletin No. 119 Mmibing
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550 First £39..
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the

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                    <text>Septenbor 25, 1953

EBB

M

meeasimal
on
Electmica

Bio-Medical

Institute cf Radio Engineem
me East 79th

New

Strut

York 21. New York

6311th
mngmsz, 1m aWrofyaux-mpandmiwd
the tmmactims. Since naming to try new poaition in St. Louis,

I have missed the transactions.
I wmld be mtaful if my mayhemhip and subscript-1m would
bu minstated at the present

We:

m Fink,
Dimcmr,

'

D.

mm Institute

M.

of Psydaiatry

sneo Amelia].

M

81:.

you very

Wis

-

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39, Missmri

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Sinmmly

ms ,

m m, H. D.
MPmlg

�</text>
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                    <text>w»

.~

Jine 17,

mm'

1977

Dr. R.A.F. Pronk and A.J.R. Simona
I'm-WWW

TNO

PO
yr

Box 5011

Utrecht, Holland
Dear Drs. Pronk and Simone,

-m‘~:a-:~ernmmw

Thank you

International

'-&gt;

“wavﬂ'n

“W

.

,A,

1-www'1w,

EEG

Appollan Hotel.

for your inquiry. I shall attend the
Congress and have requested reservations at the

I plan to return to the U.S. after the EEG meetings and
should be available the latter half of September in my laboratory.
You should know that my laboratory is 80 miles East of New York
City, about 2 hours by train.

that
that

visit

While I would be delighted to have you visit, I must say
do very little on line study. The samples of EEG traces
you sent me are very sophisticated, and surely you will want

we

to

Reginald Bickford in La Jolla, California who has a similar
system and interest. I know of no other workers involved in such research

in the Metropolitan area.

Sincerely yours,
,
.
A

‘r

v..p|n"r"._vlvm

my.»

-

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 18, 1991

Harry Prosen, M.D.
Chairman, Department of Psychiatry
Medical College of Wisconsin
9455 Watertown Plank Road
Milwaukee, WI 53226
Dear Dr. Prosen,

is with pleasure that I write this letter
It
behalf of DONALD P. HAY, M.D., in
of his

of recommendation
promotion to the
rank of Associate Professor. I have known Don for the past four years
in his research and writing on ECT and geriatric psychjiatry, and in
his work with the Association for Convulsive Therapy. As Editor of
Convulsive Therapv, I have often asked his advice about the
suitability of articles submitted to the journal, and we have
published some of his case material.
He has an active clinical practice from which he has
abstracted his experience in a useful teaching fashion. He has an
interest in education, and has been an active member of numerous
psychiatric organizations. He is willing to assume responsibility, and
has been elected Executive Director of the Association for Convulsive
on

support

Therapy in 1989.

is a dedicated, enthusiastic, empathic, and intelligent
psychiatrist. He has a well organized mind, knows the literature, and
is exceptionally sophisticated with regard to ECT and the special
problems of the treatment of the elderly. He speaks well at meetings,
command
and
Don

has a good
of teaching techniques.
I am pleased to recommend his promotion to the rank of
Associate Professor of Psychiatry, and do so with enthusiasm.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>r“

-

"r“ '

»

~

7’

-

«w:

&gt;

-- ma

mama”. I'm-u mug-em" WM“- ,.

,.

c.‘_w ,m mun

.u

I"

Vim-mu.

Far-arm.”

~.-_ V..r..,m,...-....—..W.1ww..—~mv5mm...”.77.,“

w...

_.r,

m

Wm.

“Wu“_..,.,.‘M.V.Mwinwnawh.7-..,......M,..,Ah._,.,..,w.-.....

June 26 , 1967
Box 1

Psychiatric

News

Street,

1700 18th

NM.
20009
D.C.
Washirgtm,
Gentlemen

:

is of special interest to me , not
for myself, but for associates who are interested in developing
their om research facilities in New York. As you may know,
Your advertisement

I was responsible for developing the research study program
at Hillside Hospital, 195%62, and for establishing the
research facilities in St. Louis, the Missouri Institute of
a

Psychiatry.

During this time, I have become associated and acquainted
with a nmnber of physicians who may be very suitable for this

position. Iroanbeofanyhelpinmakingsuchamcamnenda~
tion, please call on me.
Sincerely yours ,
Fink, M.D.
Proﬁesscr of Psychiatry

Max

Hszp

�</text>
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                    <text>any 19, 1969

Editor

Psychosomatico

Irvingtan,

Dear

ﬂew

Jeraay

Sir,

Enclosed are the carrcctad gallay proofs at our articlu
rgvtewing the alinical 3nd EEG effects of Doxapin. Tha dcl‘y in
their return insulted fro: my being nuly in Europe, und I trust that
tbs corrections may yet be undo.

Please revise aha 11:: of authors as indicated.

Sincltcly yours,

Fink. H.D.
Profeanot of Psychiatry

Max

mf/

�</text>
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                    <text>Munch

m». Harvey A. Robinson,

n, 1966

Hanging Editor

Disease
TraJmalofNemuomrbntal
Tho

Psychiatric Institute
Univorﬁty of Maryland

Baltimora, Maryland 21201

M w. lbw-um:

Folloudng your mentions, I have mdraftod portims of
the report ”(Molina-git: botanist“ in convulsive morapyﬂ’
corrected rm use of generic mas, and mdified the citations

toftttmstylcoftlajoxml. m motodchemgosintm
usingmyomlmgmge.

memnhmluoad,
were

altered tho title and deleted
cmtmdictow.

I

have

soon

sections

which

Ihopethatthiodmft, aﬁchIlﬂoenmhbottar, roots

with your approval.

nmk

you

for your accounts.
Sincerely

m,

Fink, H.129.
Paofesacr of Psychiatry

Max

�</text>
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                    <text>June 15. 1965

Division of 'I‘mining Grants
Public Health Sewioe
U. S. Department of Haalth, Education, and Welfam

ﬁshingtm,

D. C.

-

Gentleman:

W

Would you

please send us a copy of PHS publicatim
lejew,601:.Policy
(Milluwch
and PBS publicat
m 1302 ’
lej'cw '
Policy Statement?
1301,

Gm

85.110:me

Max

Pink.

TmSW,

m
M.D.

,

Executive Director

Mthp

�</text>
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                    <text>“v.7,“- -- pm” yr': \ rmvnrm

October 8, 1969
Dr. D. Purpura

Albert Einstein Medical Center
Department of Anatomy
Eastchester Road
Bronx 61,

New

York

Dear Dr. Purpurn:

Enclosed are two abstracts from members of this
Department for consideration for presentation at the
Eastern EEG Meetings in December.
”A

To

Physical Model of the EEG Response
Intravenous Sodium Pentothal“

”Lateralized

Convulsions"

I

EEG

Changes

after Induced

trust these are of interest to the Society.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

u

�</text>
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                    <text>June

1, 1988

Dominick P. Purpura, M.D., Dean
Albert Einstein College of Medicine
1300 Morris Park Avenue

Bronx, New York 10461
Dear Dr. Purpura,

I am puzzled by your letter of May 31, asking for an additional assessment
of Dr. Gregory Asnis' qualifications. 1 will do what Team. The request is to 'expound
on how much time and originality he contributed to these articles . . '.

Dr. Asnis came to my laboratory fresh out of his residency at the Mount
Sinai Hospital, where he had undertaken independent case material studies,
sufficient to receive the annual award for the best 'resident' presentation.
Our first published study (his {I 5) was a survey of the use of ECT in
metropolitan hospitals. The study was undertaken at my request. Sue Saferstein
was a third year medical student, and Greg Asnis was her supervisor in the study.
The commission came from the APA Task Force on Electroconvulsive Therapy. My
recollection is that I developed the design of the study; Greg and Sue Saferstein
carried it out, and wrote the initial reports; and that I edited the final report. I do
not think that Greg was interested in ECT thereafter.
The second study (his #9) was an outgrowth of an interest in abnormal
motor movements. Both Ed Sachar and Herb Meltzer had shown that active
antipsychotic drugs elevated serum prolactin. I cannot recall whether the idea of a
study came from Greg or another of our team, but my main contribution was to
develop the relationship with Ed Sachar, obtain his agreement to undertake the
assays, and make one trip to Columbia University to meet Mrs. Halpern, the
technician who carried out the assays. Greg left Stony Brook after the samples
were collected and the patient' status defined. The report was written at Columbia
University, and I received a penultimate copy for my advice. Ido not recall making
a contribution to the analyses, nor do I know what processing went on at Columbia
University.
Greg's experience at Stony Brook was marked by our unsuccessful attempt
to organize a research unit at Central lslip Psychiatric Center. I was given that
mission by Stanley Yolles, and it was a frustrating and unhappy experience.
Because we could not provide a satisfactory site for research, I urged Greg to go to
Ed Sachar (and I moved my research to the V.A.). That is one reason why his two
years with us appears so unproductive in his record.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>January 24, 1991
Dominick P. Purpura, M.D., Dean
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx NY 10461
Dear Dr. Purpura,
with pleasure that | write this letter in support of the appointment of Dr. Bertrand
the
rank of Visiting Professor of Psychiatry.
Winsberg to
It is

first met Bert in the mid-19703 when he joined the faculty of the Long Island
Research Institute, a state supported facility of the Department of Psychiatry. His work in Child
Psychiatry was a central teaching unit of our residency training program. My contacts with Bert
were in two arenas -- the administrative meetings of the senior faculty of the Department, and in
his psychopharmacologic research.
I

Bert was an active and thoughtful member of our faculty, who provided reasoned
judgement on issues of concern. He ’fought’ actively to develop a child psychiatry fellowship
program, and was enthusiastic about both the clinical research and teaching activities of the
Department. think he was sorely disappointed that we were unable to convince the hospital
administration to open an in—patient child/adolescent unit.
I

His research was mainly psychopharmacologic. When was interested in the
pharmacology of a new entity, mianserin, he studied its pharmacology and pharmacodynamics
in children and adolescents. He provided a much needed complement to our own studies in
adults. His studies of methylphenidate were also illuminating.
I

Bert left Stony Brook in the mass exodus following the decision by New York State
no longer to support the scientists of the Long Island Research Institute. He was well liked and
we were disappointed when no other funding was available.
Bert is a friendly, enthusiastic, energetic man, with a keen interest in clinical
He
has specialized skills in child psychiatry and psychopharmacology. He is an able
psychiatry.
teacher and a dogged supporter of his staff. His administrative skills are reflected in his creation
and maintenance of a Child Psychiatry Program when none existed before. He trained a skilled
staff, and encouraged young researchers to develop careers in child psychiatry.
l consider Bert
a leader in clinical psychiatry and am delighted to recommend him,
without reservation, for appointment as Visiting Professor of Psychiatry.

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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Department of Psychiatry and Behavioral Science
Health Sciences Center
State University of New York at Stony Brook
Stony Brook, New York 11794-8101
telephone: (516) 444-2990

StonyBrook
November 21, 1985
Mr. John S. Purvis
Div. Neuropharmacological Drug Products
FDA
Rockville, Maryland 20857

Dear Mr. Purvis,
reply to your inquiry of November 5, 1985 regarding the status of our
ongoing studies of mianserin, please be advised that we continue to have two
patients who are receiving mianserin. The study is continuing.
In

There have been no reportable untoward effects observed in this study.

mW
Sincerelyyurs,
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>l

E

l

i

‘

l

May 23,. 19 87

Mr. John S. Purvis
Division of Neuropharmacological Drug Products
Food 6: Drug Administration

Rockville, MD 20 857
Dear Mr. Purvis,

E

E

S

The studies of ORG 3770 (6-azamianserin) under IND ”.915 were
completed. The results were published in 1982 (Psychopharmacology 78:44-48).
We were the only investigators under this IND.
We no longer have supplies of

6-mmianserin.
Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>306‘7 . {so

géfaﬂuuggei

Ref: 72-3103

June 24, 1972
Derek Quantock, M.D., Ph.D.

N.V. Organon

Oss, Holland
Dear Derek,

We are progressing with our studies of intravenous OI~63.
In the present assays, we are using 15 mg doses, and for these subjects,
we are not finding the behavioral changes we obtained some months
ago. One thought, is the possibility that the samples I have left,
may have deteriorated; the other, is that our earlier assay was an

error.

I do not know how long it takes to make up, and to ship
additional supply of 01-63. But, I would like to re~do some
subjects at the end of this run, and for this purpose, will need
400 mg OI~63, in ampules of 10 mg each (if that is possible); or
the equivalent in the available lgfmg lots.

an

Many

thanks.
Sincerely yours,
Max

P.S.

My

trip to

One. I

Copenhagen

in

August

will write before then

Fink,

MD.

will include a side—trip to

when

I have the details before

me.

�</text>
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                    <text>A

pm

F'vv’rl-,‘p,""v:'4‘vv-

,.\d.f"1n[lpa‘rrmfhs

1w

qr
nu:

733:029
January 22, 1973
Derek Quantock, M.D.

N.V. Organon

Oss, Holland
Dear Derek,

week, but I

I regret that

trust that

we

were unable to meet during

you are

my

visit last

sufficiently recovered to accept

my

congratulations on two accounts: your new position, for which I
wish you all success; and the remarkable progress your unit has made in
developing the methodology of drug assessment. It was a remarkable
achievement which the staff demonstrated, when they replicated our studyof doxepin: the conversion, analyses, and the statistics yielded the same
data which we had achieved. It is clear that your unit in Gas is now
fully equipped to analyse records.

the extent that the first goal set in our initial discussions,
you to establish an analytic facility, has now been set,
we can now take comfort and some pride in setting the goal and its achievement.
In my discussions with Drs. Vossenaar, Bpilvogel, and Overboeck, I was
pleased to bring this success to their attention.
To

that of assisting

The next goal, that of establishing an operational test
seems well in hand. I met Dr. Leo Lange, and visited his
also
facility
You have equipped it well (Mr. v. Lierop is most
London.
in
facility
capable in seeing to the equipment needs) and I am impressed by Leo and
by his technician. We had a fruitful discussion and it should be possible
for him to replicate our methods during the next few months; and for
us to carry out a study in parallel.

I agreed to monitor his development; to agree to a common
protocdl fer the study of GB—9h; to carry out one study in New York, and
to supply a set of tapes for analysis in Gas; and to analyse the London
tapes in New York, so that two comparisons can be made: of the recording
units and of the analytic units.
Finally, on my return to New
Dr. van Riesen of Dr. Joyce
by
requested
New York. I was able to communicate the
of 01-63, as presented to me by Alan and

York,

I discussed the studies

Small with Dr. Small who was in
needs of the studies of GB—9h and
Hank, and I believe she will

�."rrﬁw‘i ,.
,

...._V,.._.

&gt;

v-7

“w 1",“ -L’r 'vm‘s—Vﬂmvo‘ 4 have” t

mr

WL‘W’rﬂv‘P-w'wn—q.“

”‘0.

was“.

,

.

.muwu ”we,

-.»-

m—

~an

,.,,

-

-2'v-lw‘

w—

«v

"‘wm.mw—-W

submit protoclla for your consideration.
This report would be incomplete without a note of
gratitude to Alan Giles, for the many courtesies he showed me, and fer
the planning that went into this visit. I very much enjoyed the discusaions
and hope that I was able to show, by my efforts, how stimulating the
many questions were. Considering the short time he has looked at EEG
issues, Alan is a remarkable young man, and I hope that he will continue
his interest in this problem.

I trust these lines find

you

well,

and hope

that

you

will

be as successful in your new position as you have been fOr Orgenon.
My very best wishes for your success.

Sincerely yours,
Ml: Fink, M.D.

�</text>
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                    <text>‘

Judith

June 20, 1979

H. Quattlebaum

President and Executive Director
National Committee on the Treatment
of Intractable Pain

P.O. Box 3h571

Washington,

D. C . 2003‘:

Dear Mrs. Quattlebaum,
My experience with Opioids in limited to experimental studies
of.the central effects of heroin, methadone and levomethadyl. and
their antagOnists, naloxone and cynlaaooine. These studies were done
between 1966 and 1972, at the New York Medical College. Some reprints
derived from these studies are attached. It is not clear to me how

;

othese experiences, which are focussed on EEG, pupillary response,
gheart rate, respiration and mood, would be helpful to your mission.
In our experience, we did find that intravenous heroin could

produce a seizure. This effeet'could be blocked by naloxone. We
‘also found_that tolerance to methadone and levomsthadyl developed
rapidly (balk days), as did tolerance to the agonist (opioid) effects

ﬁftcyclazocine.

concluded that the narcotic antagonists could be a useful
therapy'of opioid dependence, if drug delivery could be assured; but
opme to no conclusions regarding the usefulness of heroin.
1;

1
§

we

I

J],

e.

K."

-

‘

As

1.

Evidence of heroin

2.

No

effects.

See

reports.

special knowledge.

‘3, h, 5.

Not

studied.

6.

Hot as therapy; only as a "challenge"

7.

Ho.

__

‘w.
.:—‘/¢fy

.

to your specific questions;

activity of antagonists.

to determine

�J.

H. Quattlebenm

8.

2.

June 20, 1979

I could testify to the experience noted in the references.
Scheduling e drug is an aﬂminiatretive and political act,
not medicel. Nothing in our experience would suggest that
heroin is uniquely different from other opioide, except in

rate of entry to the brain and in half-life. The present
restrictions are not based on the pharmacology of heroin; but
on political considerations. Similarly, the suggestions that
heroin is a "uniquely" mofe effective analgesic than other
opioids, is not clearly pfoven.

9.
10.

No.

Probably not.

history, and my con experience from 1966—1967.
You may wish to write also to Dr. John Kramer (University or
California at Irvine) and Dr. Arthur Zeke (971 Madison Ave., N.£.I.).
11.

who haVe

Only by

extensive experience and knowledge of the pharmacology and

history of heroin use.

I trust these reports ere of

game

help.
Sincerely yours,
Fink. M.D.
Profeeeor of Peychiexry
Mex

MF:bo

Att.

�</text>
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«

1

,.y___1-__,w—-W

.

-w-ww~r“w“mww

n...

w'ﬂ-IF-m"

,.
.7

rqvww-u-nvvgyw-nmw-mraw

1-

September 2, 1970

‘

Queen's Printer
Ottawa, Canada

E

Dear

Sir:

would appreciate a copy of the LeDain report,
an enquiry into the non—medical uses of drugs, as recently puhlished.
Would you advise us as to the proper procedure to follow ?
We

Thank you.
WWF"EWW'SJ'PAWW'MP¢VF"W1

Sincerely yours,
Max

-ngm—n~mw

Pink, M.D.

Professor of Psychiatry

WW.

mf/

�</text>
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                    <text>July 25, 1991

Jacques

M.

Quen, MD.

New York State Psychiatric Association
200 Garden City Plaza
New York City 11530

Dear Dr. Quen,
I

responded to your letter of July

and Senators.

11

and wrote to my Congressmen

am interested in the guidelines for electroconvulsive therapy. Would
be possible for your office to abstract the relevant RBRVS recommended
schedules for ECT, as well as anesthesia for ECT, and send these to me?
I

it

Recently, wrote to Harvey Bluestone about the unavailability of ECT
for patients at Kings Park and Rockland Psychiatric Centers, and that their
patients were being treated at University Hospital. He wrote that my note to him
was sent to you for consideration. Dr. Oldham of OMH appointed a committee
two years ago to consider ECT in OMH hospitals; the committee under Dr.
I

Russakoff surveyed the practice (and probably found it wanting). The report has
not been made public, nor has OMH taken any action to rectify a defined lack of
services. Perhaps the matter deserves consideration by the Association?
Thank you for your help.
Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>w-u‘mm‘w

w-..

February 11, 1971
Mr. Timothy E.
Box 1459

Quill,

Amherst College

Amherst, hassachusetts 01002
Dear Mr.

Quill:

available
for this summer.
are planning a series of experiments, however,
in which volunteer males are asked to take various psychoactive
drugs, either on dingle dose or daily doses for 3 weeks. We are
interested in recording changes in behavior, brain waves and memory.
Volunteers are paid by the project.
Regrettably

If

we

We

you may wish
Irwin (212 - 369-7900,

do not have summer fellowships

to volunteer, I suggest
ext. 249) in late May.

you

call

Mr.

Sincerely yours,
Fink, M.U.
Professor of Psychiatry

Max

Mszt

Peter

�</text>
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                    <text>October 3, 1975

Fred Quitkin, M.-D.

Hillside Hospital

P. O. Box 38.
Glen Oaks, saw York Ilooh
Dear Freo;
5/?
Enclosed is a copy or the 1976/77 Program Statement and
Budge£?Requcst for the Division of Therapeutics of the Long Island
Research Institute. I think you may find this useful. The program
is set up so that we will develop all five laboratories of this

division during the next four years.

entiinterest butIthese

theiprogram.'
.
.

,

W

whether

I

The
may be modified by
"

on a more personal

knew a Enr. Fred

matter,

my

Quitkin" and

missions reflect my presthe scientists who Join

wife asked

when

me

yesterday

I said I did, she told

that your son.£s in her class. He's quite a charmer and she
looks forward to ﬁeeting you when you visit the school.

me

u.

.

‘\

'My

A

,:

regards,

“5‘ij

Sincerely yours,

v...“

.

/

l

i

MF/mr

Enc.

{1

K.

Fink, Me Do
Professor of Psychiatry

max

r

*

�</text>
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                    <text>w-V'r‘

w‘vy‘. Immnn‘fw'".

WWVNK.A

~

March
Mr. R.

a.

Sfar Roufe

l3, l969

Mannlng

Soufh Plymoufh, New York l3844
Dear Mr. Mannlng:

spoke #0 your wlfe l? was To lndlcafe fhal we have
had dlfflcullles ln obfalnlng supplies of marljuana for research
do
purposes. Whlle l would like very much To have a supply, we know
Thls
already
Perhaps
you
no? have grant funds for
purpose.
fhal The Naflonal lnsllfufe of Menfal Healfh has announced +he
believe
esfabllshmenf of a few growlng confers for marlJuana.
The
To
of
rho
mee?
needs
sclenflsfs.
They wlll affempf
When

I

I

Thank you very much

for yourlnferesf.
Slncerely yours,
Max

Fink,

M.D.

Professor of Psychlalry

MF:kp

�</text>
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                    <text>December 20. 1968
Dr. Loon Rackaw
Franklin E. Rooaavalt Hospital
ﬁentrcse, New York

la N

Dear Dr‘

f

thkow.
Dr. Roubieek and I wish to thank you for tha splendid

welcoms and

interesting visit that

we

had

last

weak.

I

have

also

received the notes you sent ané haw. read chaos before sending them

on

ta

Dr. Freadnnn.

opportunity to: rasaatch at your hospital era indeed
I
will
encautnge Dr. Freadmnn ta establish the ralationahip
bright
which will paruit somber: of this staff :0 participata 1n the
special programs whiah the VA has aatabliahad. In reading the
reportn. I van most interested that half the patiento ware nude:
44 ycurs of age and that of theta, half taunincd less than two wecks,
suggesting thgt the population is more acute than was initially repr¢~
and

The

canted.

Again. our thanks fer year enthusiasm and I

Ftoaéman and the

visit

noon.

staff here will

trust

havu an occasion to discuss

Dr.

this

lineeraly yours,
Fink, M.D.
Prafesuor of ?aych1atty

Max

�</text>
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                    <text>December 20. 1968
Dr 9

“on

Franklin

“at“
Roouevclt Hospital

D.

Honttoae, Rev tbrk
Dan: Dr. Knekow.

Br. Roubteak and I with to thank you for the splendid
intereating visit that we had last wmak. I hava also
received the notes you sent and have read thaae before sending than

welcoma and

on to Dr. Yraeéman.

for taxaarch at your haspital art indeed
I will encourage Dr. Frﬁeﬂman ta establish the relationship
ahich will parmit mambers mi this staff to participat$ 1n the
apocial programs which the VA has astablsshed. In raading the
vaports. I was most intareﬁtqd that half the patients were unéer
Mb yum-'3 of age and that. 0f these, half remaineé less than two weeks.
tuggasting that the population is mare acute than wag initially rapt.»
vented.
bright
‘

an&amp;

The apportunity

Again, our thanks for your euthuaiasm and I truat Dr.
Praodaan and uh: staff hare will have an occasion to discuss thin
Vitit soon.

linceraly yours,
Fink, .5.
Professor of Paychiatty

Max

112'

�December 15, 1968
To: Dr. A. M. Freedman, Chairman
From:

Max

Subject:

Fink, M.D.

Visit to

VA

Hospital, Montrose, December 11,

1968

At your suggestion, I visited Montrose VA and was
receved enthusiastically by the Director, Dr. Rackow. Dr. Roubicek
accompanied me on the visit. We met two of his associates and visited the
research facilities in experimental psychology and chemistry, and
the projected space for additional research programs. Dr. Rackow was

most

enthusiastic, cordial

and cooperative.

hospital is at least 1 hour from our present facility.
It is a typical chronic care institution with the majority patients
in residence for more than a decade. Schizophrenia is the principal
diagnosis, but alcoholism, brain damage and psychopathy are frequent.
Depressive states are rare.
The

1

Dr. Rackow has no resident physrﬁcians and is unhappy with
the present Dean's Committee which has emphasized committments elesewhere
in preference to his institution. He asks that a research and/or training
relationship be established, and anticipating the move to Westchester

asks

if it

could be done now.

Advantages: The VA has funds and has shown a flexibility in
other centers that is greater than other chronic care institutions. THe
center can provide funds, space and chronic mentally ill for a large
scale research and training situation, especially in research methodology.
Dr. Rackow

is enthusiastic

and cooperative.

Disadvantages: Distance from the present site is the
principal drawback. All the advantages of the VA center can be
provided by Manhattan State Hospital, if the Director of that
hospital could be convinced of the merit of cooperating as Dr.
Rackow sees it.
Employees recommended to the VA would have to sign loyalty
and
non—citizens are not permitted on the preserve in any
oaths,

official capacity.

Recommendations:
If an American

citizen of high academic stature could be
found, interested in developing the research or teaching program,
the opportunity would be of importance as both a source of salary
supplementation of senior staff, of patient populations for research,
and of much needed laboratory space.

The same could be develOped more cheaply, with less
travel restrictions, and with less dependence on citizenship, in
the state services. If we need such a facility (and we do) I would
urge another effort at developing the relationship at Manhattan

�State Hospital; and

Rackow.

for

VA

if that fails, reconsider discussions with

Dr.

(Note: Dr. Rackow will need a proposal and candidates
funds by early Spring for funding in 1969—1970)

(Note 2: Dr. H. C. Denber has volunteered to allow the
of
his ward for the students and residents, and would consider
use
-expanding his facility under your auspices. This solution would
not allow for our staff to write orders and treat patients directly

unless Dr.

Diamond

agrees Specifically).

Max

Fink,

M.D.

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                    <text>"7.,” ,,

~--—

—

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...«_w-..e,~J-_ rum'vxuifﬁ

,

uvwamrwv“WNW

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v,

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any n»... in

...w

rrwwuvwmuw'«-~.——..

‘w.

»

‘. YT...

“

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Octobar 22, 1975

PM

L.

mm. “.8.

Central E1¢nnnt:ry'8chool

Fourth Awunun &amp; Bueand Struts an.
8%. Cloud, Hinnosot: 56301
Dear Mr. Badman.

unknown

I rugret to any tha£ the ansvnr to your quastion is
to no. I do not know if Ill. und (bugle children differ

in their lavnla or

I
in Holland.

ABTH.

ham. sent your

letter

on

to Prottssor

David doWiod

3. in the principgl invoctignmor of this

and perhaps ha

will

haw! an unswur

program

fbr you.
Sincerely yours,
Pink, M. D.
Profbasor of Psychiatry

Max

MF/ur

.10.“, ,.

,. .

.«rw

,

,4

..

.

.,

�</text>
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‘17.... an.“ m, .... .7- .-m—.-.:,...

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_

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,_

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v .

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v

.
v4

'Wmm;w——nm

March 1, 1977
Mr. P. Rageth
we,“

an“.

S. Karger

AG

Basel, Switzerland
Dear

Sir:

"EEG

I have reviewed the page proof of the article,
and Task Performance after ACTH u-io in Man". There are no

-v-...»~wn~v—me._muvr

remaining corrections except the following:
~v

f
a,

V

m.wv~—w.q-

Dr. Halter Sannita has returned to his native Italy,
may be more helpful to list my name, Dr. M. Fink, as the
addressee for reprint requests (bottom of page 882). It is more
likely that cards addressed to me will be delivered properly.

it

As

"rm

.w.

a.

.
'Mw»

Sincerely yours,

w_-L—w:‘«.~=-wmvw

My,

”mun

"an.

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>\ﬁ
—~

June 11. 1963

Paul

stotto,

W

H. D.

Dimctsur dos
Psydmim'iquss
napiml St-ourm . m Janette
1000 Baal. Sta-Anne
Janette, P. Que.

m

User Paul:

mr
envision.

to
Conwtulstiom on yam new assimnt. The
of
since
how
no
I
difficult
is
your qmstim
mention the
spans available, nor the types of program yw

For

m1¢.ifﬂ1slsbiopdmilyo1hﬁosl,ﬂma&amp;usmsis
possibly best; but, if mm, than a more sensitive amplifier
be

remanded.
May I suggest you visit Mac-35.11 and ask the advice of the
(whammplsostlmgass) «ormllm‘. Santer£8631“me
Fonsr at Qmsn Hsry‘s and ask his advice.

system (Offnsr) my

Sampls

notssmtobe obtainsdbywx-itingOffnevand

Gr'sssat:
(for Offnsr information)

Immm.

Badman
Spinoo Division
901 Oxford Street

Grass

Inc.

Imtnmnt

Quincy,
U.S.A.

Tormto 18. Ontario

Hssssohmtts

Canada

Good

luck.
Sinesnsly yours ,
Max

Fink,

Director

MP:jr

Germany

101 Old Colony Road

M.

D.

�</text>
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1?

(:2

\jldﬂ.2“‘,¢«-r,..,~‘?m_m
,

Member 22, 1953

M. 9.
biota.
0mm Paychiatriquc

Paul

W

dc

Janette

1090: Boulevard Saints-Mm

Janette,
Canada

Boar Paul:

Wyouwxymdafarywimuiry. mutate!

ﬁmtmporthmhominpmfoermthymmm

hasmtasyotboenpublishod. Ido'mthavomympiw,ﬁnn-n
fame. Inmaloaing, hmm,afileoapyafmtmiclo. I
trust that it will be helpful to you.
I d° “a!” VOW W laboratories am mrldng well.
’5'

best

regard-3'.

Sincerely yum-g,

m Pink. )4. 1)..

mm
Hfmlg

ma.

1

pg

aha"

r"!

I!

���</text>
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                    <text>Jane 10, 196‘

teal nsjotte
lnotitut do Reohercheo Psychiatriques
do Joliotta

Dr.

Hopitsl Saint-Charloo

1000, Boul. StawAnne
Quebec. Canada

Joliette.

Dear Paul:
would be pleased to have Dr. Normand Giard spend some time

we

the Missouri Institute of Psychiatry to

our

EEG

laboratory.

become

acquainted with

at

With regard to the actual dates, there are too problems with
October 15~19 - Dr. Itil will probably not be back until the end
of that week. as I do not expect him officially until the 12th.
I plan to be away at tho American EEG Society meetings from
October 1 to 5. and will probably not be back until the 8th. at
I on planning to spend a few days in Los Angeles. For these
reasons, I would suggest that Dr. Giard come after October 11.

while the accommodations of the St. Louis State Hospital are not
the vary boot. we hove on occasion been sble to make them availsble to visitors. As he is coming alono. I will do my best to
provide sons place for him during his visit.
My

beet regards.
Sincerely yours,
Fink,
Director

Hex

MF/jb

M.D.

�</text>
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                    <text>September 21. 1964

Paul Rajoteo, M.D.

Institut

Do

Roehorohos Psychiatriqoos Do

Hopital Saint~€harloo
1000. Soul. Sto‘Anno

Jollotu,

Jolletco

Quoboo

Door Paul:
would be pleased to have Dr. Glard visit with us. and look forward
to having you visit us on the 213:. W! will provide him with a place
to work, and give him to opportunity o6 participate in the EEG program.
I do not know whether 3:. 1:11 will be back by that data, but I will do

we

my

boat to help.

‘

'

there is a Sheraton Hotel in St. Louis._1t is in tho downtown
lootion and somewhat distant from the hospital. The two closest and
While

nicest motels to the Instituto ore the

Admiral-Bonbow Inn, 5120 Baklund
Blvd., St. Louis, no. and the Bol~A1r Hotel on 4630 Lindell Blvd., St.
Louis, Mb. If you do not widh.to make the reservations from Montreal,
we will be glad to provide them hare.

Sincerely yours.

:4“ Fink’
Dlroctor

mf/la

MOD.

�</text>
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                    <text>November 12 , 196%

Paul Rajotte, M.D.
Hopital Saint—Charles
1000, Boul. Ste-Anne

Joliette,

Quebec

Dear Paul:
The local newspaper, the St. Louis Posthad
an editorial regarding your problems in
Dispatch
Canada. It seemed to me to be sympathetic to the
views expressed by yourself and Dr. Giard. I thought
you would

like to see

information.

it

and enclose

it

for your

Sincerely yours ,
Max

Pink,

Director

mf/ ls

e nclosure

M.D.

�</text>
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                    <text>Sﬂptldbﬁr 29. 1966

Dr. Paul

anotte

Juliette.

Quebec

Hapital Saint Charles
Canada

Dear Paul.

enjoyed talking to you in
returning to New York have
been able to review the opportunities and the

I very

mudh

Madrid. and since

study programs at this College.

I would, indeed, be interested in reviewing
your curriculum vitae and in arranging for you
to visit New York at your earliest convenience.
My

best regards.
Sincerely yours.

‘.

.,,r,

,
u.”

Max

a

Avg—“-

73;.“r-"x-“uv

‘*"&gt;¢;

ﬂww—m—Vr—g-zum-

,

Pink. 3.0.

Professor of Psychiatry

�</text>
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                    <text>Novanber

Dr. Paul Rajotte
Institut de Recherches Psychiatriques de

Hopital Saint Charles
1000 Bwlevard Ste. Anne
'

Joliette,
Canada

l,

1966'

Jolictte

Quebec

'

DearDr.Rajotte:

Itwouldbeapleasmtoluveyouvisitwithusif

youareavailableanydayofthemekochvanber7crlu,
excaptNovenberllandls.

'I'hebesttimfcrmisanyaftmfsz:00pnon.

Iwillalsommgeforyoutomttlnﬂmimlmoftm

Departnent.
Ext.

If you wish to
2'45.

My

confirm this, please

best mgardsr

call

(212) 369-7900

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mfkp

�</text>
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                    <text>December 18, 1969
Dr. S. Venkat Ramani
1918

New

First

York,

Avenue

ﬂow York 10029

Dear Dr. Ramoni ,

for your application for a fellowship.
are unable to consider additional
appointments at this time, but will hold your letter in
I

Thank you

regret that

our

files,

we

pending a change in our programs.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>x
&lt;-.~,

7'

-.
w

,—._-

w.

an”,

August 10, 1972
yww‘wwavmwﬂ-JW-n

Allan Ramsay, M.D.
National Institute of Mental Health
Rockville, Maryland 20852

ewaquup4m‘n

Dear Allan,
-vu-.r.wa-

N,

nag-'3'

..a:a,,.g.—~

Separately, we have filed an IND for cyclazocine for the
on-going studies at the Metropolitan Mental Health Center, and I ahve
requested Dr. Levine to institute the proper procedures with Mr. Boyer
to sustain our supplies. He will tell you that we are treating about
80 patients daily, and while the majority are receiving 4~5 mg/day, there
are at least 12 who receive 8—11 mg/day, and we are proceeding in a
few to 20 mg/day.

Paralleltstudies of Z~cyclazocine are in progress. For
the present, we have adequate supplies, but these should he exhauseudd
within three months.

file

for chyclazocine, or will MIME
provide us with the supplies to continue the ongoing studies under our
Should we

new

contract

of the

FDA

a new IND

?‘

If we should file an IND, will you request the cooperation
regarding the extent of the submission ?
Will additional supplies be available through Mr. Boyer or

from Sterling-Winthrop

?

Meanwhile, we have hegun the study of haloperidol; the
animal pharmacology of diprenorphine is delayed by supplies from
England, which have been promised for later this month; and the study
of BC-2605 has been delayed by an administrative problem, which we feel

will

be resolved by the end of the month.

Thanks, again, for your help.

Sincerely yours,

:_.

ZV'N-aq

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>ﬂovonbor 22, 1972

Alan Ramsey, M.D.
Modicnl Consultant

National Inititute of Mental Health
5600 Fishers Lena
Rockville, Haryland 20852
Boar Dr. Ramsey:
Undnr the torn: of contract
studies are in progress.

88M

42-72—207, the following
_

(l) ﬂelogeridgl. Twonty~four opiate dependent non have
been withdrawn from heroin using decreasing doses of methadone and
placed on either halopcridol 10 mg or placebo. Both groups have
been given 4 mg of benzotropine with each dose of active drug or
placebo. he methods of evaluation set forth in the contract are
being uncd. The remaining subjects have received medication for
two months or longer. An evaluation will be available in February
March, 1973.

study

(2)

Naloxono panoate.

was completed

The dooc~duration of antagonism

in early September.

We

defined a

maximum

tion of 60 houra for 6 cc parenteral. A copy of the: report
sent to you, and submitted to Cliu. Phanm. Thckap.
(3)

Czclgggging.

Tho high dose

study

dura-

was

is continuing the

definition of eccoptability, tolerance, and duration of antagonism
to heroin. Ho ounnerircd the data of 20 mg oral, noting blockade
to 25 mg heroin for 72 hours. A copy of that report is oncloocd.
1639 (naltrcxone). ‘wn provided a protocol for the
and filed on IND application for the FDA on
compound
this
study
October 25. this was rcgintcrtd as received on Hovcnbcr 10. 1972.
Of

(4)

EH

Additional details of our aporetion were providod in your
extensive site~vioit of October 26.

-

�Alan Ramsay,

Hovonbcr 22, 1972

3.3.

You may

also be internscod in parallcl studios

now

rlsu in tho Division:

in prog-

a. _Digrcnogghino. H. at. enopnrating with the Citybeof
canHaw Yeti in datining annual toxicology studion. which should
platad by the and of tho your.
b. Lovonnthggzl, We conplctod a second study of lava—
uethadyl and confirmed our earlier rnport that‘ao :3 won effective
for 72 hours, allowing a t.i.w. dosage schedule.
Sincoraly yours,
Fink, 3.9.
Professor of Psychiatry

Max

MF:1g

ﬁne.

�</text>
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73$B*5h3A

February 26th . 1973

Alta Runny, Md)”
medical

mutant,

(:11an Drug Studs.”

Canter for Maudie;

Section,

or Eutectic and

Drug Abuse,

anticml Institute of hunts]. Health.

5606 Fisher: Lam,
Rock's-111.,

mama 20852.

Dona-Alan,
The work at
mart haw to

is going Quite well. we have taught
the
ayalmcine and nethadona.
the use or harem challenges. aha-um the program: continues: ,
the

VA

must“

m

be able to assign patina on an alternate but: to
amimoina
and methadone within the next
weeks.
V111

6—8

This study was awn-d by tha human Adainiatmtion
on November 6th, 1972. A copy or that approval is enclosed
for your ﬁler, as in a. copy at our permit. Amara“).

m
a unwind in the contract proposal
I look inward to having yen and Steve 8m with
at your comninncu.
grim for the study
“hunted to HIM.

mama-013'

Mu:

Fink,

ymra .

11.13.

Frofeam of Paychntry
20/15
M: .

�</text>
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7383—509

January 30th, 1973
Alan Ramseyg M.D.,

Medical Consultant,

r

Clinical

f

Drug Studies

ﬁectibn,

far Studies of Harcotie and Drug Abuse.
Ratianal Institute of Mbntal Health,
Center

5

5600 Planers Lane,
Rockwille, Maryland 20852”

3

§

Re:

HSMkhauTarllﬁ

Dear hector Ramﬁey,

3

Attached is the quarterly report of the studies of
cyclazocine and mathadone at the VAR—Northport. Two
considerations are brought to=your attention which

;

i/~

5

3'

‘

supplement the formal

report.

1. It was our understanding that various itams of
equipment would be made available to the program, to
supplement those we anticipated bringing'to ﬁUNY~Stony
Brook from Raw York Mbdlcal College. We requested, and
believe we received approval, for a storage safe,
pupillomnter, printing calculater, and

h

channel~FM

reearder; WE indicated we would supply an Electroencephalo~
graph, oscilloscope, oscillator, and a tape analytic systam
(IBM 1800). These latter items were shipped to Stony Brook
on December 7, 1972.

;
g

v
v

ﬁ'ﬂm.’"-m71':.=m'.";ﬁr

m

A
.

2. At the formal site visit on November 16th, the
question or randam assignment of subjects to methadone and
cyclazocine was raised. While VB believed wn coula achieve
such assignment. yam: consultant, Dr. Raymond Knawles,
raised a quastion of ethics with sufficient acervity that our
Vﬁﬁ associates have requested that fbr the present, VB
assign patients on the basis of patient choice.

is otherviae progressing wall. we have
suaeessfully inducted three patients to cyclazocine during
Docamber, and undertook our first heroin challenges in
The program

�6

E

Alan Emmy. Md).

January 30th. 1973

While the mangmntu are still tenuous,
3mm.
eatsblished
to
ta

outpatienta.

’g

«2—-

Freewares

eantim

we have

treat patients as

E

gimerely yours ,

E

E

Fink, Md).
m
Professor of Psychiatry

:

Proaeat

.{

WI 1.1

..-

.

,zh-2‘\(’“1’:C”HPZW7'

‘

Dimtor

�</text>
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                    <text>June 22nd. 1973
Hr. H. 8. Vellum.

1:10..
northern-m
07110.
Nutley,

NJ.

mam,

.

Eula-ed. in e list or the blood eeuplee delivered
on Friday to your office. You will note
cue «elm
inﬂate: the drug alas (1, 2. 3) end mother
aw
drug code. reflecting e tendon augment. I indicated to
Dr.
that em or the tubes bed erected; tint we
bed need different tube: far different
of the new;
end thet in e few hut-mu we hm! en edditiouel +2): hour

mt

Sam:

.

calm.“

We

ample.

I regret that

we

bed so much

difﬁculty with getting

the» blood mlee. but can ewe you thee should the
study meat 11:. we will repeat thou Me. including
mum-1 blood emlee. ea m be meeeery.
Hy

beet

rem“.

Sincerely years.

*3 ”It,

Hebe

Preteen: of

thtetry

�</text>
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                    <text>rm“
f

7383~787SB
26 ﬁavaubcr 1973

subtcription Dupartunnt
Internatiannl Coancil on

Aleohol and Addiction.
Cane Postal: 1‘0
1001 Launannc
SHITZIRLARD

in:

Change of Address

which you

nail your publica»

ﬁcntlanan:

Plain. chtnsa the adds... to

tion to as

addruss:

from

th- uddrosn nttadhad bolav to the following

9%.

as: I!!!

DEPARTMENT OF PSYCHIATII
ICHOOL
HIBICINE
HEAETH SCIENCES CRETE!

0!

8.9.N.Y. AI $10!? 3390K
810“! BROOK. NEH YORK 11790

0.8.A.
Thank you.

Sinatraly,
Ha: Fink. E.D.
Profculor of Psychiatry

Mllcts

�</text>
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October 15, 1973

Laonnrd 8. Brahon. Ph.D.. H.D.
Dir-ate: of Radical Ina-arch and léucntion
County of Nassau
Dcpaxtnnnt of Drug &amp; Alenhol Addiction
214 Glen Cave Rand
Carla Elude, Haw York 11514

Dist Lani

I rcsret thlt I will b. unable to attend the conference on
naltrexan. on.Ictober 25. As I inéicntad to your ca~workar. I am
leaving for Europe on October 22 and shall be away for thrae weeks.
I

hope ch.

slasion is fruitful.
Sincerely years.

an: Fink, 14.15.
trotcauor of Paychiacry
Kilcil

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7

David

W.

Harris,

January 1974

M.D.

Chief of Staff
Votcrcno Administration
Franklin Dolano Roosevelt Hospital
Mbntroco. How York 10548
Rn:

620/11

Door Dr. Barrio:

Itii.

I

on writing in support of tho apnlicction of Tutnn M.
M.D.. as a resourch psychiatrist at tho V.A. in Mantra-o.

I

havo known Dr.

Itii

ninoo 1958, when our

common

interest

offocto of psychotropic drugs brought no togcthor
incarnationcl
on
coating in Roma. I was instruacntcl in
at
him
Unitcd Statoo in 1963 at his rcccnt posithe
to
bringing
tion at the Minnouri Inititutc of Psychiatry.
in tho

BEG

Be is an outstanding roooarch ocicntint who has workod with
onthuoincn and order in dcvcloping tho whoio fiold of quantita»

tivo ole-trouncophclography and it: applications to clinical psychiotty. In tho many yccrl that on workcd coauthor, I found him
enthusiastic and innovative. no is a dolightfnl person to know
and has

friend. all over the wotlé.

I an pica-0d to :oconnond him no I research psychiatrict
to tho V.A., and I on confidant that his contributions to tho

V.A. progrcao

will be significant.

Sincorcly yours,
Fink, M.D.
Profocoor of Psychiatry

Max

MF/cio

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                    <text>74AP~009AP

7

Junnnry 1974

Gerald L. Klnrnan, M.D.

Suportntandant
Erich Lindtaann anneal ﬁnalth Cancun
Govurnnnnt Cantu:
Sultan. Hasutchusatcn 02114
Dun: Garry:

I hang

gong ovur tho 11st o£“1ndiv1dunln under conﬂidarn-

tian for gloatinn to tho APPA. Thar. arc.unny nuns: about than
I know littlu; for thosa with when I an aeguaintod. I hav: a

The following aro ruceunnndnd for unabordhip:
Cnncro, Gurshon. Inglis, Mbore. Hoshnr, Quintin, Rnsniek,
Rifkin, 3nd Shophard.

fun onunnnto.

I ball-v0 that c. c. Duhlbcrg has 6106.
I an troubled by only an: nan: that I know, that of

A.

Diunacio. While
is a fin: axporinantnliut. my recon: can:nctn with his as a follow aaionciat hnvo bccn unplaanant, and
I vauld ho rcsnrvnd about ro¢ounnndtng him for nunbership in
an crannisation like tbs APPA. My rgstrvations are not very
strong. but his rigidity would anus. I. to try no clue: 0th.:1f thay at. I! Will qualified.
A1

Sincoroly yearn.

m min. 14.1).
HP/cis

�</text>
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                    <text>August 13, 1953
Mr. A.

Systems

a.

Randolph

Wing Laboratories,

P. 0. Box 91%

Inc.

Port undamale 10, Florida
Dear Hr. Randolph:

Mummies maul

W
mt,
mmxtalandmtcstingitformapplimtiom.
In". John

kind

Stem of the

to

form your latter of July

the mamas. At the pmamt

I

am

we

Health Cantu was

23, 1983 mgarding
have an 133 1710 systw:

@0113th of your instrument and
I should be mum. for an invitation.

interested in a

intruevontthat it 13an15331:th St. Imaismain
few
tha

mt

14me

months,

Simly your-a.

Fink, H.
m
Director

D.

»

�</text>
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                    <text>;1

i
{E

I

my 23,

1969

Dr. Axel Rendrup

Sect

Hospital

Hans

4000 Roekilde

Denmark

Dear Dr. Rnndrup:

Enclosed is a cepy of the report of the symposium
"Experimental and Clinical EEG" in Liege. Would you

make any corrections or additions which you feel
necessary, and add relevant citations using the same

please

style that I did?
The

corrections

directly to:

and

citations should be sent

Dr. G. Verdeeux

Centre paychietrique Sainte-Anne
Laboratoire d’E.E.G.
1, rue Cabanis
75

Paris

France

I

was

very

and noradrenalin
I hope I quoted

14c

much impressed

with your theory of dopamine

sensitive syntems for the neuroleptice.
it correctly.

For many years I have been interested in the convulsive
therapy process. Some time ago I summarized the biochemical
evidence for cholinergic mechanisms and attempted to relate
the changes in EEG and behavior to the little biochemistry
that I could find in the literature. I am taking the liberty
of enclosing a copy of that report and would like to ask your
comments regarding the following questions from your experience:
In there any evidence for ECT for
any of the neurohumors similar to that
which you presented for the neuroleptics?

�t

11W‘V‘ﬁwt'quﬁWxI'awa-rr

Hum/m!

‘

'-

.-'—n.'.

-2-

Dr. Randrup

Can you recommend any

May

23, 1969

additional

workers or rcforonces regarding the cholinergic
nochonismo or other nourohunoral machinisns
which may be involvod in induced convulsions?
Do you have any theory of the
mochaninn of convulsions from a biochemical]

pharmacological point of View?

and hope
to continue our discussions
know
me
let
that when next you are in New York that you ofwill
associatos.
my
meat
scan
to
for
you
so that I can arrange
Many thanks for your participation in our seminar.

I

would

likc vary

much

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkp

�</text>
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                    <text>m17'r

«.vwwgm-m

.v.

1......” 73--..

.

..

,w

”m mm

aﬂv

...,,—_.

&lt;.Wuw-'Ax-».-.v

r: '.v.~4www.m‘--“nmV14:"-9:'—-;=

(Irrhnr'a‘nii' n’u'yv.»

..

-r\ .~....-w

ma

w...

Tu'u'”

.1“. .

qm—

A“

,

a... “wen—um .411..."

.-

..

June 15, 1976

Judith Rapaport, M.D.
Department of Pediatrics

Georgetown University Hospital

Washington, D.C. 20007
Dear Judy,

have read your report with interest, and some
on to
sorrow that the results were not more positive. I have sent
We
should
hear from
Dr. Menditwicz and the Journal Neuropsychobiology.
him shortly.

I

it

‘

Henk will be coming to see you Thursday. Please excuse
I hope that I
as I shall be busy with my daughter's graduation.
'
will be able to cash in a rain—check shortly.
me

v

I'mwr.

My

regards.

W‘s-W1

rr

-mz-..-v-v—-

Sincerely yours,

'0.‘l:-'rmm

,1”

AV

«um-M.

.
«wry

t‘riﬁ'ﬂ’nwm“

ku—ry-

run.“

.

wwa.m~,-uwwuu.;-

ww-wmux-wo

.mm’n'rrt

131.27?

my:

an:

Professor of Psychiatry

�</text>
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                    <text>Octobar 30th, 1972
A1

Rankin. Ph.D..

Clinia:l Research Branch.

Hational Iantitubo of Mhntal He‘lth.
5600 Fishers Lana,
Roekville. Mhryland 20852.
Deur A1,

the recent EEG mnetings, I had the occanion.to disauas
projects with various workara, inaludins Whiter
Obrébt az Duke. He in ‘aquainted with the cardiovascular
and can: of the aerebral offoctu of hypafbnrie chambers.
It may be useful for yuur project to revicv his work.
At
Queuing

Thu wanting; also aurfuood name advances in portrayal
of result: that arc buuaming inerigaingly aw‘ildble. and
which may improvn ycur proposed studies.

Bincarely yours.

Fink, M.D.
Profasnor of Psychiatry
Mhz

mm:

�</text>
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                    <text>March 9, 1967

Dr. Allen Raskin
Research Psychologist
Psychoplmmacology Research Branch
National Institute of Mental Health
Bethesda, Maryland 2001::
Dear Allen,

Iwasverypatefulfortheopportunitytcreadthefirst

paw,

and would
report of the collaborative depression study
and
most interesting
like to congratulate you on your clear
presentation. It was especially rewarding to find that the
clinical efficacy of chlcrprcnezim in depressive disorders was
confirmed, for I can clearly recall the difficulties and
anxieties with the first Hillside study which appeared to be

oontmrytotheprevailingopinions- mtonlyregardingthe

treatment of depressith inrespmse toamyththat
chlcrpmnazine could induce depressions (1958-59).
Your study

indicates that the canbination of dﬂorpmnazine

and procyclidim was no more effective in the treatnmt of
depression than chlorpmnazine alone and the detailed measures

stew that procyclidine was exerting some pharmacological effects.
Perhaps we were still under the influence of the state of the
art for we tried chlorpmnazine alone in only a few patients,
'

fearing that the side effects wmld be too great; and then,
the patients tolerated the combination, we were

when we found

sopleasedthatwemdertookthecanpamtive studyofthe

combination against ﬂuipramine.

the merits of the culmination were, in part,
a response to the often asked question as to whether the
efficacy of the coubination in depression may have been due to
Our focus on

thepmcyclidinealmeaxri, inpart, tothefavorablereports
in the literature which appeared to be consistent with
out observations. We did treat five patients with procyclidine
alone, and discontinued the study for reasons that are unclear
to me today.

we found

�1‘”

Dr. Rankin

~2-

March

9,

1967

Aslreadycnmmportlmadeafewmtesaxﬂlslmotl'nse

withyouas commute, wtoritioism.

‘

_

MonumtonpageQIogaxdingtl‘nlmincidea-xceofeompymidal reactions with chlorprunazine alone is puzzling. Is
it possible that the patients did not get their medication as

prescribed, or that antiparkinson medication was made available
outside the regular record keeping procedures? 0n occasims,
both at hillside and in Miami, such puzzling observations were

fumdtobemlatedtoextm—medicalpmcedmsmdtheclinioel

factsmmmtsodiscmpentwithourclinioolexperionceasthis
observation would
imply.

Table 3 has most interestim date. The combinatim appears
to enhmoe or sustain excitement - an observation consistent
with the defined BEG effects of parocyclidine‘; and to enhame
drymssofthemrthandblumimofvisim-possiblemleted
to the antiornlinergic properties of pmcyolidine. that
interesting, Wet, is the clear denmstmtion that adaptetim
to the secmdary
effects of drowsiness, nasal congestion, blm'red
visimamilossofappetitedoesocctm-ﬂmscmfimingmm
clinical
It is here that the similarities of the
combination to the chlor-prunazine slam are so convincing.

swim.

Inthediswssimwogelmtheopeningpamgmphenlarges
foamsesmtmincidehoeofseoondaxyeffects. Theimidenoe

ontrnattritionmtecflﬂforthsactive mumts,m1d

mpwmdismttoohigxincowarismtoclinioelexperimoe,

mmmoontmststmldbemdemtwithnotmetmnt
or with placebo moment but with other
accepted ‘matmnts

fordepressivedisorderasﬁcrammipzmim. Amtheseside
effectsandtheattritionmtedisoomdmtwith that whichwas

observedinﬁxsimipzmimstudy? ‘misaqmasismsyperhaps
bemdifiedbyymmsubsequent emerienoe.

Mfiming'thetcwdosagermgemsyhavebemtoohigh
ismtuwwected,forwehadbeenworkingwithapowlationof
ﬁnrapyfailmsandhadedjmtedqmdomtobeabovethat
neededbyﬁOtoftlntestgrow. Sincethen,Ihavefoundthat
chlotpmmine dosages of 500 - 800 m are generally adequate.

Assimletmethankymfortlwoppommitytomedthis

ropes-mendfortmmtlutyoumyedomwrlsssstudyat
Hillsideinmfiningmmobsmations. 11001ch with
Mantidpetimtoﬁumtmpmsofﬂndepmssionsumy.
Many themes and my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc: Dr. Jonathan 0. Cole

�</text>
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                    <text>July 26,

1957

Dr. Allen Raakin
Research Psychologist
Psychophamacology Research Branch
National Institute of Mental Health
5494 Wisconsin Avenue
Chevy muse, Maryland 20203
Dear Allen,
Thank you very much for yam letter of July ll. I have
called three of the investigators m the list as well as
Dr. Bird and Dr. Itil. I famd the vacation schedules to be
so varied that no satisfactory meeting date could be selected

until after Labor Day.
For this reason, I have not gone ahead with our suggested
amngmnts and will call you soon after Labor Day regarding
the possibility of a meeting at that time.
Again,

my

tharﬂ&lt;s and my

best wishes for. a pleasant
Sincerely yours ,

an

w'

Max

rink,

M.D.

Professor of Psydﬂatry

“umsmmmnwur

MF:kp

smarter.

�</text>
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                    <text>.r-ws

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9cm; 5,7196;

Dr. AITen Raskin

Research Psychaiogist

a

APsychapharmacology Research Braﬁdh
National Instituta of Manta] Health
.5454 wisconsin"Avenue~f"~
Chevy Chase, Maryland 20203

‘

‘

;

Eear A11en,'
.I want to thank you far your supportfand
intérest.dur1ng
the recent cyclazocine conference in Reassalier. I hope that
:this compound-can be assayﬁd by the ﬂIME study groups. It
would be-most.hé1pfu1 ta know if'the prasent trantment models
n_£an indeed be faiated to their EEG profiles, and if a new group“
of antidepresSants exist in the antinarcqtics.

l

I.havg written a suggested prgtccal, and have sent the
original to Br,.Jaseph Bird 9f Sterling-Hinthrop.’ He is
particuiar3y interestgé fﬁ‘this°eva1ugtien.and has agreed to
organize these Speciai stadieS; Wouidryou‘srﬁtique this
suggested proposal and eithér write Gr 6&amp;1} him with-your
suggestions? If~a proposal can be agreed to, I-trust
will be abIe to BSstt us in the necessary arrangementsyouwith
the study grsups;

,gl

.

'

;

‘Again,”my thiﬂkSé .~

Singeve}y yourSs

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:

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cc:

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-Dr.'81rd

I

Fink, ﬁQD.
‘Prafessor of Psychiatry
Max

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�</text>
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                    <text>August 19, l968
Dr. Allen Raskin
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland

,

Dear Allen,

Enclosed are the initial reports on cyclazocine as an
antidepressant as submitted for publication. I trust these
meet your expectations. Dr. Bird has called to say that he

plans to hold

a meeting

in late September.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF2kp

�</text>
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March 2“, 1969

Dr. Allen Raskin
National Institutes of Mental Health
514514

Wisconsin
(base, Marylmd

Chevy

Dear

Ir.

Raskin:

have recently completed our report of the trials
of cyclazocine as an antidepressant. I am writing to
aakifmytrialsbygmpe ctherﬁxmAbuzzambaMSchiele
have been reported, and if so, if the data is available.
We

Many

thanks.

Simly
Max

rink;

yams,
M.D.

Professor of Psychiatry

MF:kp

,

WWW-aw

w" m,wvva

Viv-w,-.

a?

�</text>
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                    <text>"Mm-"-

nx—an

mm mu“..-

.

_I.

7.

,

_

,

r.

,

.l

.

“www.mw, we“. ”aur.:g2;qusm;

W"..-"

uv'

U,

~

rap-mum‘-

November 12. 1970

mnmv-w—Vm

mem

7

Dr. Allen Rankin
Research Psychologist
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015

Ya

qr

.FWy—v—

Dear Allen,

for the opportunity to read your report on
depression subtypes. Taken together with Jonathan's heroic
effort to be optimistic about the variety of new studies,
your study indicates clearly that the present antidepressant
drugs are an unsatisfactory answer to depressive illness.
In part, this was presaged when, in reviewing the neuro-~
physiology of different psychoactive drug groups for the
ACNP in 1968, I found four drug classes with four different
neurophysiology patterns a reflection that no one treatment
Thank you

“var

.,

_...,.._..._,~.

,1...

_

A

_—..

—

.-..-H.—rv,w-v—u—

was

satisfactory.

.

Vx-wn'rnwv~

.w

.4
..

.0.

a

,ivﬂ-

warm-”v...“

”Wm

The reawakened

interest in

1966-67

in unilateral electrode

in multiple treatments in convulsive therapy led me
to reopen my studies of ECT, and we have made some interesting
observations. It is possible to effectively treat depressive
or
patients (of any age) within 3-5 days, without measurable
made
by
possible
is
Such
treatment
rapid
clinical memory loss.
seizure
of
and
rate
oxygenation
placement,
changes in electrode
induction.
that ECT is the primary treatment for a
It is apparent
and
that drug treatments may be most useful
depressive state,
regimens.
and
maintenance
as adjuvants

placement and

- ECT comparisons are probably useful in
the combinations
delineating the relative dosages of each, andThis
"radical" view
Imipramine

most

suitable for each depression subtype.
the initial startle reaction
it, despite
needing answers are two:
questions
specific

has much to commend
may excite. The

it

.w.-m,1.._...

WNVWW w'o. maln&gt;wwmm

�w.

-lwwww-

ww

“V.

W,”

._....A.,.

.

,~(v,'q

ww

_&lt;,..

,._—._

.t.

,W...‘,_

m

‘.,

“a “j ..

Dr. Raskin

November 12, 1970

-2—

(1)

For each of the

psychotic, schizophrenia), is

3

ECT

depressive subtypes, (neurotic,
equally useful?

(2) To what extent is a supplementary drug therapy
necessary for each subtype; and which ”antidepressant" drug is
most useful?
A direct comparison of EC? and imipraminc should confirm
the superiority of imipramine, as the Greenhlatt-Grosaer and
Shepherd~NRC studies showed. (There are 5 other studies quoted
by Klein and Davis showing ECT equal or better than imipramine.)
Perhaps, the typology and predictor approach is more useful new.

We

‘wwv—mr-wnu

-

y”

Mandela

have tried to confirm the Carney, the Robson and the
predictor scores in our recent ECT study and were

unsuccessful.

is our latest report as sent to the Archives. I
of the active ECT workers, and I look forward to discussing
this work with you in Puerto Rico.
Enclosed

know many

.-—

Again, thanks for the preprint.

.m.

wry».

Sincerely yours,
‘Wv-Fm-Mn

Max

.wrw-v

«ow—pp

mr’

-

:WﬂvT'WTW’WJrV-‘WW_Z~UWMM~

r-u

Fink gen.

Professor of Psychiatry

r,"

‘(F :kt
811C 0

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                    <text>“run. :r,~cr§'f" “an...“ Jury-my s... -.u ~rﬁr-WI'JFW-Vav: ”w

m7

V

~~

,

ya

«yr-wuuvvwnwmna

v

mnw‘? Maw-v: ~&gt;mmw&lt;-

mm

roan—pr“

‘v-Iww'r‘wawr-V“

.

,

,,.,

October 23, 1970
Dr. Allen Raskin
PRB~NIMH

5456 Wisconsin Avenue
Chevy Chase, Maryland

Dear Allen,

I very much enjoyed your presentation in New York on
Thursday, and I am writing to ask if you could make a copy of the
preprint available for my liesurely reading. If I understood the
text, the first study confirmed the Hillside findings except that

of the subclassifications which we found responsive to the
different drugs were blurred. The second study is a clear statement
of the limitations of the proposed antidepressants.
some

and ECT,

are in

?

Is there any consideration to a comparison of imipramine
or a more detailed study of ECT, now that these results

It is

a fine study and

my

congratulations.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
mf/

�</text>
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                    <text>catcher IOth, 1972

All” MWI 293MB. 5

Research Ptyéhologist.
Pnyuhaahirnnablogy RatiIrah arIaah.
national InatituﬁI at Mantal HIIlth.
5600 rilhawt Lune,
Rockvillo, MIrylnnd 26852.

Allan.
I ha IﬂrI d the nglieItion. "gzgg;~:ggd HormobIr1g
*as~1n 1» $021 11’” ‘v1th intcrost. As undIrItInd thc
prapOII1.'3O patients will be assigned in h cohorts of 20 cash

Dear

I

ta hypcr~ and nornder1¢ oxygen I31 I11; with four dIyI
910~t10I1aIaz515 aIyI of troatunnt with 2 IIIIionI I day.
Ina cvuluItionI on day 16 (Ind 1 7) Thnjpr1n¢1ptl tout

1nItrunIntI arI thy ﬂichalar unwary scale, Bender Gosttlt.
steakton acrittr1e IeIle. ThIII instrumIntI are selectcd
1n pu1t, thy 1n$asr1ty at thI contrnl nervouc
refleet1ng.
II

and

system.

_

sinae'ihn Itudy Ittcupts ta rIplicItI curlior Itudiea
ﬂhtturc cauld be
the report by
Talton at
I31 natcd that tth aarriad out auroral EEG
analyses without £1nd1na ehInJII. Unfortunatcly, they did
not doaaribe the size of sample nor the tauporal rclItion of
the EEG mIIIurII to other tIIkI.
1n whieh EEG vurinbla uIrI IIIIurad, thiI
1n¢1udad.5 A: part of our rcvtnv, II road

5;

In raw1avin; th1I praposcl with my coavorkort. VI boliovn
Ihould be praat1eIl to record 320 atlplﬂl from then.
pat1cnts; to- gravide quantitat1vc aIIIurII o! traqnnney.
amplitude. and varinbility ahInaII; Inn to relate thIIe to Inch
‘uﬂllﬂrOl at behavior, part1eulIrly of eogn1t1vb partormnnca.
'ﬂl may be axillable. A Iuggestcd prubocel. bIIed an our
undorsﬁgad1ng of the project tram thI dooumcntu provided. is

that

1%

appoaded.3

Our IngsIIt1onI Ire based on an IvnranIII thIt recording
during thI actual sessionI would be too coutxy and.controln
toe difficult to ash: such recora1ng In 1nhorcnt part of the
study. Rathsr, In use the EEG nIIIureI prov1d1ng 1ndcp¢ndInt
1nétces of change: 1n brain funct1on, their extant Ind duration.
1n parallel to the measure: of cognitive performance.

�Allan RIIkin, Ph.D.

OIIobIr 10th, 1972

~2-

IhII III

WI III InssIII1n3

EEG

IIIIrdI II IbIIinId

III plIIIbo pIr1od III fur IIIlimatiIation. III III

Inr1ng

II III IIII11II analyliI.
WI

III IIIIIrnId

IhII IhIII patients

may be

rIIIiving

pIthIIIIpia III IIIII1vI IIIiIII1onI during III
record IIII III IpIIify IhI nInnIr
IIIIII of III IIIIy. TII V111
1a Ih1Ih IIIIIIIIII drugs
II IrIIIII. Binco III EEG 1:
highly IIII1I1VI Io pIthoIrIpic qugI. Iither all drug: Ihnuld
II withdrImn I1I*Ih1Ih IIII I long VIIhnauI pIr1od, ngIIIr
IbIn 3 IIIkI. IIuld II IIIIIIIry) or. IIrI ahcnld bI IIkIn
that III IIIIIII'I usual nId1III1III II IIIIiIIId Ihroughout
III IIuﬁy 1n the IIII IIIIIII III III IIII IIhIdulo as
various

during the III~IVIluII10n pIr1Id.

BIIIIII_II hIwI {IIII IIII 1nIIrw1nII1tuI1InI1 yrIJIIII
rIquirI IddiIiInal IIII, II IussIII I p110I study {Ir III
IIIord1ng IIIIIII. IrIintag of pIrIonnnl 1n III IpII1Il
rIqu1rIIIIII It the IIIII. Ind {III1b111Iy or III var1ous

IIIIIIIIII It the I1III IpIIifiId.
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IlIIIrIII IIIIrdins IyIIIII, may prav1dq IhIII IIII.
IIIII InadingI IIId III II done by the IIII IIII aiing
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II III1I1II II III protocol.1 hIVI Iubuitted I 11st
at Ihi Iqu1pIInI vhleh vuuld II rIquirId for such I study, and
III1IIIII IhI IIIII {Ir Ibo IIIIJI inrolvbd.1£ III suggIII1InI
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more

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,

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III rIporII IuacIII IhIngII

flaw, and while II hIVI no airIII IIpIriInII with
tho proIIdanI. II think IhII rhIoInIIphIlongphy any
contribuII II the IIIItioII poIId. ThI IcahninII hlVC bIIn
IIIII IIudy {Ir many yIIrI II Bocklnad State HospitIl by
1n vascular

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should

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III probIb111Iy If 1nI1uI10n 1n IhI study II h1gh.w
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III prIpIrI I aorI-forIIl rIviIv I! III 11IIrIIurI of

EEG

�Anon Rankin. mm.

~3~

Octabw 10th. 1972

ottoctaaﬂlﬁhwporbcrie tad nornanrie oxygen and tho methods
ywoﬁoeal to unqt tn: ﬁends at :n
inaugrltaa utudy; and apply fur the acedtnary institutional

u: unplay; nodity uh:
.

aypwovulxé

’

{uy‘heqtvresurds.
Iaincnroly yéurl.

m mat, Mm,
“Ilia

ecu Sc

..
m.m’ﬁuanﬁ
‘

-

�</text>
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                    <text>mmnmwxmw

A

November

1hth. 1972

Allen Rankin. Ph.D.,
Beeenreh Psychologist,

Peyehapherneeology Research Branch,
National Inetitute of Mental Health,
Sksh ﬂinconein £70.,
Chevy Chase. Maryland 20203.

Deer Allen,‘

I can underetend ﬁne relucteuee or the eaumittee to
increase the costs of the project. In our review, we vere
impressed that the daze an the etfeets of hypeﬁberic oxygen

lent themselves to a more rigoreue measure by using
phyeiologieel indieee.

Perheyl, if the first study show! eons cheese: which
are of clinieel merit an a result of the procedure, then
perhaps the more deteiled studies would be warranted.
my

best regards,

”Whi-

mmmm‘vv

i

sincerexy yours.

1“!

Flu.

Mad).

Professor of Psychiatry

MF/iJ

�</text>
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                    <text>February 15, 1966

E.

Ratimff.

t

EM).

of Mammy

Haunt Sinai. fioapitnl

5th

New

Amman and 100th

York,

New

York

Strut

Dear Dr. Batinoff :

Wt
mmmdlmgmtmthavingboanabletomit.

Imjmtmiwdmmmmntofﬂnmthly
of Neuroloy for May.

omfemnoe of the

library

1%.

The

title

of yum mwrt

inmmts

me

wry

yum ago we undertook observations of amtyloholim
levels (twins abotmomvulsivn tummy, and warn particularly
Mamet in the earlier obmatims of Bomstein in

Sam

macs.
We
obmations
If

the
reported an availablo in a pmprint
fem, Iwmldbegmteful forenopportmitytomadﬂnmpon
taminmat wayﬂnobaowatiom mymlatetoourm
studies.

Please extend

my

personal

new to Dr.

Bender.

Sincerely yours,
Max

Mfajm

mm,

21.9.

memcr of Psychiatry

�</text>
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                <text/>
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      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
  <item itemId="2260" public="1" featured="0">
    <fileContainer>
      <file fileId="1397">
        <src>http://exhibits.library.stonybrook.edu/mfp/files/original/8187ab5e9c81837d49ca31a881ac7363.pdf</src>
        <authentication>268eb7472152a1a55d2190e811bc93b1</authentication>
        <elementSetContainer>
          <elementSet elementSetId="4">
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              <element elementId="52">
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                <elementTextContainer>
                  <elementText elementTextId="102023">
                    <text>’3?"

'

-

m-rwl;t='v$

LP"W

:z—Kanv‘u

'4«»'-"’~719’;U'r"-

m

7,

1966

Dr. E. C. Betinoff
of Neurology
ﬂaunt Sinai Hospital
100th Street at Fifth Aveme
New York, New York

t

Dear Dr. Patinoff :
than): ym very and:

for your letter. I

am

pleased

toencloeeeoopyofemportmwheebemmpted
Nam/om and Mental
for publioetim

014w“.

by the

Jam 0‘

We have not mderteken any wetylcholine studies
during the past few years. When in New York. however,
I etteepted such studies and fmmd that the eoetyloholine
using clan heart preparations, were so
unstable that we mum never satisfactorily mlete
We did, however, mder'tehe
time
of duelineeteme in spinal fluids chasing the convulsive
therapy process. We dete were incomplete, and we were
meble to cowlete these with sufficient mm]. for e
aetiefwtory resolution of the quatims.

mama,

mm“.

mum“

this mvieu indicates. I believe that the
studies
of Bomstein, and those of Twer and
early
omtm‘butions. and
Whom we still the mjaindeed
venerated.
that e ﬁrmer study is
As

this idea in

mind, I was interested in your
be
would
I
pleased to have an opportunity to
report.

with

W it.

Sincerely yours ,

~
-

2'

rv-rvner-rsw

11-71417W‘W:mw'“3wrwvwr;m3ﬁ

Mex

Hfsjmh

Fink,

M. 1).

Professor of Psydxiatry

�</text>
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                    <text>rr.

,r.

r.»

memuvww

March 5, 1968

r“

u

wwyljr

,Wa—=«.Wn

Mr. Vincent L. Reyaschieri
l03~l Avion Hay

Minot

a.“

"a.”

AFB

Minot. north Dakota 5870l
Dear Mr. Ravaschieri:

‘
"
'
"
'

w,

WM"-’S""

We»

1.1-

2—way

Ware-ﬂmmr‘

Thank you for your reply to our ad in the New York Times
for a Research Assistant. We are interested in your qualifications and would like you to communicate with us further as the
time approaches for your military separation, regarding the
possibility of a position in our laboratories.
Our research involves the evaluation of changes in brain
function associated with pharmacologic agents based on digitalcomputer EEG analysis. using as subjects. psychiatric patients,
narcotic addicts, and normal volunteers. The enclosed reprints
will give you an indication of our studies.

w

We

.

look forward to hearing from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

kp

..

‘6er

�</text>
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                    <text>73AP~768AP
15 Novunbar 1973

Donald

Elain,

M.D.. Troasurar

Annrican Psychoyathological Association, Inc.

Htllsida 30:91:31
Glen Oaks. new

Yomk

11004

Dear Don:

It 1: tr“. that one can buy and 3011 shnren of the thnan
Corporttion at thin 13 a elooadacné invescncn: trust-1t has
a limited number at churns outstanding which are sold on the
cpun market. Considnrin; tho dcbacla which has oceurrnd this
week, it may be prudoat ta 0.11 p‘rt of the charts now and ins
vast the profits at 8! in Treasury bills or 8.5! in government
bonds 0

I spoha to Mrs. Podrid this afternoon.‘ Sha told as chit
aha knaw of no probluna with the APPA program. Should you find
that. are any probleus, 91...: call no.
..,

Sincurely yours.

rnmruumrm,

"“7“

WV

”4

Max

3:,

m/cis
cc:

Dr.

J. Cole

Fink.

M.D.

�</text>
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                    <text>INTERNATIONAL ASSOCIATION FOR PSYCHIATRIC RESEARCH, Inc.
BOX

457, St.

lames, NY.

I

I780

l5I6I 862—665]
(516) 444-2929

July 12, 1991

Chown
Exmouth House
3-11 Pine Street
London EC1R OJH
Davall

&amp;

UK

Dear Ms. Ravenhill,
was either in the British Medical Journal or Lancet that a news story
within
the past six months noting an unusual report by an Australian
appeared
Royal Commission (presumably medical) which explored the claims of a
scientist that Deep Sleep Therapy was particularly useful in treating the mentally
ill. The inquiry was launched because of allegations of deaths associated with
It

this treatment, and the Commission was reported to have found the methods
unsafe and recommended their discontinuation. lack the original note as it was
sent to my librarian who returned only a note from the Royal Society in London
that Davall &amp; Chown was a source for this material. enclose a copy of their
leﬁen
I

I

based on experience with insulin coma therapy of
psychoses, electroconvulsive therapy, and what has conventionally been called
’sleep therapy’ without the ’deep’ modifier. The latter therapy was described in
1922 by Swiss psychiatrists, and was used until the late 19305 when insulin
coma and electroconvulsive therapy were replacements.
My interest is

I

would be grateful for your help.
Sincerely yours,

ﬂwab‘wc

Max Fink, M.D.
Executive Director

�llNTERPUNHCNVAL/K
SSOCIATION FOR P SYCFHATRK:RESEARC}ilnC

&amp;m4315Lmnmst&lt;H7&amp;)

(516)862-6651
(516)444—2929

July 2, 1991
Davall &amp; Chown
Exmouth House
3-11 Pine Street
OJH
London EC1R
UK

Gentlemen:
We

of the Australian
copy
a
obtain
I have beenb
Therapy.
would like to
Sleep
on Deep

Report
Royal Commission is available from your
advised that
FAX

it

office.

the charges for
to
as
advise
Please 8604.

this report.

#: 516 862

Thank you.

Sincerely yours,
Fink, M.D.
Executive Director

Max

Our

�</text>
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                    <text>W.

&lt;-

'm'mnw—Iwnnwv-7r"--

.amn‘

"ﬁre-"v .- .7

“wen-my“, w .W. my. r-w.'7,—

July 14. 1969
Mr. Denison Rey

Squadron end Piesent
292 Madison Avenue
New York. New York 10017

Dear Mr. Rey:

It was kind of you to bring my attention to the case of the
U.S. vs. Finley. Unfortunately. I do not consider myself an
experifin marijuana having Just begun our studies less than one
ago. I do not have any information which has not been pubiished
gear
and could do no more then present data which is not
others
y
from

this laboratory.

Sincereiy yours.
Fink, ".0.
Professor of Psychiatry

Max

Nthp

.1

�</text>
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                    <text>September 29, 1965

Dr. Mark Rayport
Department of

Nemlogical Surgery

Albert Einstein. College of Medicine
New

York 51, New York

Dear Dr. Ramon:

six copies of an abstract entitled
of Dissociatim of 2m and Behavior with
Anﬁemlimrgic Agents.“ by Dr. Itil md myself, for your
omnidhmtim of tho forthcoming meeting of the America:
Enclosed are our

"The Qmstion

Sincerely yours,
Max

Fink, H.D.

meesm of

enclosures

Psydmiatry

�</text>
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                    <text>“(v-e-«nww-l

July 13, 1970
Dr. Richard Rech
Department of Pharmacology
Dartmouth Medical School
Hanover, Raw Hampshire 03755

Dear Dr. Roch,

In Aspen this year, Fred Brunet suggested that a session on
and drugs be organised for 1971. I believe I was supposed
to send you some saterial, and some recent reprints are enclosed.

EEG

Sorry for the delay.
From

active

the point of View of human psychopharmacology, the most
is being done by the following:

work

C. Shagass

I. Itil

A. Kales
C. Pfeiffer

—

-

~

Evoked responses

Sleep EEG
Sleep EEG
Amplitude Integration

Recently, I have become interested in the effects of unilateral
on the EC! process, and we have
observed differential EEG effects which are closely related to changes
in visual or auditory memory tasks. .This type of study, in animals
and nan may also be of interest to the participants of the Aspen
and

bilateral electrode placement

sessions.

Is there anything that needs doing in September/October? [I
away in August.]

will be
My

best regards.
Sincerely yours,

5

Fink, H.D.
Professor of Psychiatry

wnwr:

Max

mam-nu:

r
.-

w-v..-e~

Mr:kt

,v

cc: Dr. F. Brunet
BBC e

�</text>
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..

”my." uwm

H.737-

w... )Iusl‘l'w‘umw‘1Y

wnv,~mu-vmmmza.

.

w ,

«,H.“

~._v.-

w:

“‘-

"wﬂw

WWW-Av."

r
-.
&lt;

.

”mu—amu-

"a...“

September 28, 1970

um:.-v~m.-m.«-.

uwz‘.n'

IW‘V‘

Wm

Gmmm‘

mim

W

Dr. Richard H. Roch

Associate Professor of Pharmacology
Dartmouth Medical School
Hanover, New Hampshire 03755
Dear Dick,
Thank you for the outline of the 1971 Aspen meeting
program. Both Itil and I will participate. Shagass is unable

to attend but suggested either Heninger (Yale) or Seletn (Univ.
of Missouri) as capable alternates. Before inviting them, I
wonder if we don't have enough with five speakers? There are
2 hours allowed and I think we prefer discussion to another
speaker.

;

seem fine.
one for me.

Titles

enclose

Looking forward

to

I have asked

Itil

for

an

abstract,

Aspen.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

and

,_

m’- u—wvv-w.

1-

:

‘_,_ rx

m.

�</text>
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                    <text>w.

.w

w-~r

v

WWF‘WW

emu-W

Mfr?

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology
Dartmouth Medical School
New Hampshire 03755

Hanover,

Dear Dick,

write a useful review of EEG and drugs is probably a
idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
good

Review of Pharmacology,

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
To

other processes with which association—dissociation theory has
to deal.
In sum, the idea

WW‘IM'WWWN'Lty

unI-x'w

-.:.ur"N'

a—nwma-

'nvtr‘rlwwaw-mwamm‘J.

To

may

be

interesting but

I do not see a

central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CNS
changes induced by drugs" is grand and unfocussed at this time,
and probably very difficult to focus.

It

in

Aspen and the memories sustain me through the
in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

of

days

Sincerely yours,
an

p:.-~n.-rzuv.c~

Max

.u—wq

w".

'

-r'x:~mnu1«..

":1

.

Fink, M.D.

Professor of Psychiatry

r,

MF:kt

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'

1
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'
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-

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology

Dartmouth Medical School
‘Hanover, New Hampshire 03755
Dear Dick,

write a useful review of EEG and drugs is probably a
good idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
To

Review of Pharmacology.

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
other processes with which association-dissociation theory has
to deal.
To

In sum, the idea may be interesting but I do not see a
central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CKS
changes induced by drugs” is grand and unfocussed at this time,
and probably very difficult to focus.

It

in ASpen and the memories sustain me through the
of days in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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WWW

7-

..,,V____._.-,,__._k..,.,.w._..”WWW.,,--,_“,_,__..‘_WHWWWWWWVWW‘"WWWW,“

”w

V.~W..n.,._wm,._m-_W-____W,V.MW-.__m,.....,.mu“.

October 13, 1985

Allan Redunduffm. 81.0.
Associate hot-ham

“vanity of Chicago

The
950 East 59th

Chicago 37.

Strut

Illinois

Dar Dr. Bachﬂdnffm:
ﬁnding mpy is «Inland.

Your

comma will be appreciated.

Sinmnly yam ,

HF:

jnh

Pink, H.D.
m
Professor of Payduiatry

.m.‘m.-‘\_.__..wm_.-

�</text>
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