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                    <text>Wm WT...- ﬁr “WV—mm-

nv-vw'

.»wwm"ww.ﬂw

March 10, 1975
Ms. Maya

Pines

Washington, D.C. 20008
Dear Ms. Bines,

is a report written last
status of the research efforts in the peptides.
Enclosed

May

on the

Since then, some Of the reports have been published;
the studies in convulsive therapy have had some preliminary results;
and studies in the elderly and mentally retarded have been designed,
funded, and are in progress.
WW.“

N__

n"...

The

latest findings are those reported

by David DeWied

effects of vasopressin; the studies of Kastin supporting
central effects for ACTH h—lO; the reports by Itil that THE, another
polypeptide has CNS effects; and the animal studies by McGaugh,Gold
on the

CNS

and van Buskirk.

I trust these data are of

some

interest.

Sincerely yours,

~.....

_,.__,......-m

'v‘m‘w"wnrJl-remI-5Wun._.wv

nw-wr

r~
ran

.

-A

..

.
‘9‘“.

WW.

rem“

Professor of Psychiatry

�</text>
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                    <text>MW~

~ w—"q—w—gw

-»-.

rw-vww

"vu

__.‘.

.
"gm-"w

.1» w.

k

August ’4. 1975
Ms. Maya

Pinea‘

h72h 32nd

Street,

washington,

N. w.

20008

Pines,

Dear Ms.

m.

D. C.

for alerting me to the latest issue of Saturday
to the fine article that you wrote. It does capture the
excitement of our work. ORG 2766, the long acting peptide. will be in
clinical trial in Europe and the U. 8. this winter. It is going through
human toxicology trials now. Among the early tests in the U. S. will be
assays of its effects on the EEG and on memory function, and in elderly
patients. The studies of ACTH h~hlfin the elderly are in progress now
at New York Medical College and Néw York University, and soon will also
boast the Hillside Hospital in New York.
and

Thank you

Your

article was well written

and described the state of the
you.may wish

art well. Perhaps, among your other writing assignments,
to tackle another interesting story.
The human EEG has been

studied since

its first

published

report by Hans Berger in 1929. During these hs years, there have been
many applications, including some of those described in the Saturdgy
Review. One interesting development which is not widely known is the use
of EEG methods to find new drugs for clinical psychiatry. Since the first
descriptions of modern psychoactive drugs in the early 1950's, most cons
pounds developed by industry are based on their similarity to an ettablished compound, or to their effects on animal assay systems. The first
methods produce "me, too" drugs; the latter are often inaccurate, for
someilIuInnds that are psychoactive do not satisfy the animal assay
‘

criteria,

useless.

and some compounds

that

meet assay requirements are

clinically

quantitative EEG analysis has been successful in providing
a classification of psychoactive drugs that is based on neurophysiologic,
The

not on chemical criteria; and new psychoactive compounds have been found
by these methods.

�‘V’nwr

wuss-r:

r‘wr‘l-YW'

V

7.77 ._

.. nu war

WWW‘IC'W‘wummmw—VVnruwman-rm—w

"1. war "W"‘m‘ -wn.w.~A—a-.r-a—mm.w~rnrw—qw—~nwr-sm—r—mvw

M's.

Maya

,

g
i
-

rmr-~

4

—:.-,

W;

cm.

y!"7!f‘l‘7"*‘

.

qmiuvw-prw—u.—

-—.-1-.-

wmawW..—V.w-ywu-.m

Slit/75

-*

EEG methods hare also been extended to estimates of the half
bioavailability of drugs. This latter use has become important
as the FDA has demanded that drugs from different manufacturers meet
stringent standards of safety, purity, and availability to the patient.
These studies show an intimate relation between changes in
brain function and behavior in man. Some physiologists describe the
electrical activity of the brain as a 'matabolite' of brain function,
reflecting its underlying activityh.
The quantitative analysis of EEG is distinctly different from
the clinical analysis of EEG.as is ordinarily done by neurologists. It
depends on careful control of the setting of the experiment, and measure—
ments or the EEG, using digital computer analytic methods. A review of
these developments would be timely, for it will provide the lay reader

life

E

Pines

m—N

and

with another

View of brain function to complenont his information of
depth electrodes, chemtrodca, biofeedback, and sleep research.
-

.

I

am

enclosing two reprints describing this work, one for
that may give you a better idea of this topic.

1969, and one for l97h,
Again,

have an opportunity

congratulatiOns on a fine report. Perhaps
to meet'to discuss this interesting project.

my

we

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Max

MF/mr

Enos.

will

,

7

Wm, e..-

um

v.7. V...”—

__

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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitts, Jr.

Department of Psychiatry
Renard Hospital
4940 Audubon

St. Louis, Missouri 63110

Dear Dr.

Pitts:

It was a pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved as three months
of work.

are anxious to replicate your study and would be
grateful for an initial supply of one-half molar sodium
We

lactate.

Our discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administration of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor

who

is a third year resident undertaking this study.
Incidentally, I will be in St. Louis on Monday or Tuesday,

August 12-13 and

if

we

can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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October 31, 1969
Dr. Ferris Pitts
Washington University School of Medicine
4940 Audubon
St. Louis, Missouri 63110
Dear Pete,
We completed our study of sodium lactate and when we
summarized the data found that we contributed very little
in addition to what you had presented. A copy of our interim
report is enclosed. Nevertheless, it seemed worthwhile to
include a statement in the literature that your work was
confirmed. My associates and I have, therefore, drafted the
enclosed letter which has been sent to the New Engﬂand
Joannal 05 Medicine. I trust
will appear and it should
permit you to refer to the work of this laboratory as
confirming the data presented in 1967.

it

This may become important since the Aachtveé 05
Genaaaﬁ Paychéatag contained some criticism of your work
which I must admit was not too clear to me.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp
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                    <text>February 19, 1971
Dr.

Ferris Pitts

Washington University School of Mbdicine
660 South Kingshighway

St. Louis. Missouri
Dear Dr.

mm

a
~:L

.w.

57.

“may

“.1.

,a‘
(

WWI-V

Wnrva"

Pitts:

Seminars in Psychiatry, 3 new quarterly publication edited
by Milton Greenblatt and Ernest Hartmanu, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I am pleased you have accepted the invitation
to contribute the report on "Medical Aspects of BCT”. The notes in

the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200~3OO

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced page: (including

7

($11?"ng

63110

To meet

citations).

the publishers deadline, can you

by the end of June?

make a

draft available

"m"

maumnm.

47

m

,5.

an!)

W

It is

a policy of the seminars to re~iesue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

'01

I

x...

V.

;L-v

hope you can

join us.
Sincerely yours,

nz—w-m-wwm

I/rJ

en;

"r“:

Max

mm.

.IWV.‘7

‘HT’E'T

a
U-Z'

a.

WWW/1’

‘34

‘:

«um-"c

--

.7“!

"my"

Fink, M.D.

Professor of Psychiatry

an'

MF:kt

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                    <text>November 8, l97l

Dr.

Ferris Plffs

Sf. Louis, Mlssourl
Dear Pefe,

varlous arflcles for The ECT Issues of Semlnars
of fhe publlshers. The Index and
Psychlafry are
Idenflflcaflon nofes for The aufhors are enclosed, and If fhere Is
an error, please lef me know.
The

In

The galley proofs should
In February.

fhe Issue Is due

arrlve wlfhln

6

The publlsher ls grateful, and will send
fhe journal.
fo
subscrlpflon
And,

—-

..

.quv—m»

In fhe hands

I

flnally,

hope fhe Issue Is wedl

be.

Many

fhanks.

I

weeks, and
you a

van? #0 fhank you for the fine arflcle.
know fhaf your reporf wIII

recelved, for

I

“awn-”am.

-v—v

Slncerely yours,

mm...

..
v
w-

n“

-.—.-

WW

~qu

vw-r

wwu—w—WWF—I'MEWFW

Max

Flnk,

M.D.

Professor of Psychlafry

�</text>
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                    <text>Janunry 11, 1972

or. Ferris Pitts

1035 Bellview Avenue
St. Louis, Missouri 63117

Dear Peta:

I want to take this opportunity to thank you for your
contribution to the February 1972 issue of SeananA in PaychiaIAg.
I have seen the page proofs and the issue should be out within
four weeks.
a small payment for your participation in this volume,
I have asked the publisher to aako available 100 reprints of this
urticle without cost to you. You may wish to review your reprint
needs with this in nind.
As

ﬁy

bolt regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

ﬂrzig

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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitta, Jr.

Department of Psychiatry
Renard Hospital
$940 Audubon

St. Louis, Missouri 63110

Pitts:

Dear Dr.

pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved us three months
of work.

It

was a

are anxious to replicate your study and would be
grateful for an initial supply of onenhalf molar sodium
We

lactate.

discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administratiOn of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor
who is a third year resident undertaking this study.
Our

Incidentally, I will

August 12-13 and

if

we

be in St. Louis on Mbnday or Tuesday.
can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>ouch“

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September 27, 1968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis, Missouri 63ll0

Dear Pete,

to take this opportunity to thank you for the time
in
demonstrating your techniques and for the supplies
you Spent
of sodium lactate. They arrived with minimum breakage and we
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
the continuation of our study.
I want

it

I found my visit so interesting that I discussed
with
Dr. Freedman, who would like to invite you to give a talk to
our full staff. The subject can be a sunnmry of your studies
in anxiety, or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

a

I will call you later in the
date that is acceptable.
My

week and

will try to work out

best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

H

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wt!

.e..-;_

m...-

~wxw..m_~m .- ‘. m&lt;mnvlfmw .mwpgq..."

._

“Wu-w v" 1;» .mvw': .v.w-w=w...w . a...

Haw-«~—rue—m

”n.-

..wu—w

—~-) erma—mua

n...

7...".-.

...w..;w‘w.. ”up.

September 27. l968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis. Missouri 63ll0
Dear

Pete,

you for the time
and
for the supplies
you spent in demonstrating your techniques
and we
minimum
with
breakage
arrived
sodium
of
lactate. They
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
I want

to take this opportunity to thank

the continuation of our study.

it

with
I found my visit so interesting that I discussed
talk
a
to
would
to
give
who
invite
like to
Dr. Freedman,
you
of
be
studies
The
can
a
summary
your
subject
our full staff.

in anxiety. or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

will call you later in the
date that is acceptable.
I

a

my

week and

will try to work out

best regards.
Sincerely yours,
Fink. N.U.
Professor of Psychiatry

Max

Mszp

.

”M17”

,s

-...-.,..H.

7“,...

n...

�</text>
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                    <text>February 9, l968
Dr. Nonman Pitts
Chas. Pfizer a Co., Inc.

Groton. Connecticut
Dear Dr.

Pitts:

Enclosed is a revised protocol for the continuation of

our Doxepin studies. You will note that the next group of
newly admitted anxiety cases will receive doxepin without

necessarily havtng‘a preliminary period of treatment with

doxepin.

Please

amend our

project file.

Also, thank you for the matching capsules of doxepin,
chlordiazepoxide and placebo which arrived yesterday (Thursday).
I

look forward to seeing you March 7,

3pm

at

5

East lOan St.

Sincerely yours,
Max

Fink,

M.D.

Professor of rsychiatry

MF:kp

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.W'Jn

Aw...”

..

1v

May

7, l968

Dr. Norman Pitts
Chas. Pfizer &amp; Co., Inc.

Groton, Connecticut
Dear Dr.

Pitts:

Separately I have sent you the summaries and behavioral
rating scales of the subjects receiving Doxepin in our initial
Mental Health Clinic study. Enclosed is our interim report
which is our summary of this information.
I

trust these are helpful.
Sincerely yours.

F
1‘

.
I“

Max

I

amwuwusql

.MWVL.‘

w“.

;
1],.

w

-,
,
.

"14:54“

raw-r"

‘RM‘W‘Marwwwwmil/Mm!xi»

Fink, H.D.

Professor of Psychiatry

m-“

Mszp

�</text>
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                    <text>July l8, l968
Dr. Norman Pitts
Chas. Pfizer &amp; Co.

Groton, Connecticut
Dear Norman.

but

The second oral doxepin study is now being completed
are in need of additional supplies. Would you please

we

send us:
12

bottles -

l2 bottles

—

per bottle

50 mg

-

lOO

25 mg

—

100 per

bottle

We are actively doing the EEG study as well and have
completed three volunteers. I need a few more in order to
establish a definitive doxepin dosage.

Thank you

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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.—

.Nn

”‘5‘

w-

.p

mm

1.,

w

v,-u...y.-u;...«.-.—yi.—.

-

,3

October
Dr. Norman

l0.

196$

Pitts

Chas. Pfizer a Co., Inc.
Groton, Connecticut 06340
Dear Norman.

part of the review of our experiences in the clinical
we have completed this report which may be of
interest to you. especially in interpreting some of the clinical
data in studies using chlordiazepoxide as a comparison drug.
As

doxepin study,

Sincerely yours.
Fink, ﬁ.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>September 9, 1968
Dr. Norman

Chas

Pfizer

Pitts
&amp;

Co.

Groton, Uonnecticut
Dear Norm,

I look forward to your visit sometime in the next
few weeks. We are actively involved in the EEG study
and I will request a review of the ongoing DoxepinChlordiazepoxide study so that I may have some data when
you come.

In the meantime, would you please send us an
additional supply of doxepin ? The present labels read,
"Sinequan, 25 mg.."l00 caps/ bottle, (white and black
capasules).
Would you
Many

arrange to send lelOO

?

thanks.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>‘

“ﬂy ,. :rrxmww,

run-'rm'- ‘L-w‘“"".p-‘--W'r»w~.~\-r':.wny

Jr'r.‘-VWwyun

w

February

~./~.,.-V.~...-‘.wav-».m

”w“.

-ﬂ..‘. 7. 7,.

7.

‘

”,1. ,

MT-“ __. ,. ,...r., ”u“,

6 , 1969

Dr. Norman Pit-ts

was. Pfizer

Gmtm,

8 CO:

Cmctimt

Dear Norman,

is a swam of the clinical laboratory observatims
mien should be added to the mummy
datsd January 7 , 1969 (III) . ihis laboratory data is sumitted
Enclosed

in the omoing

Boxepin study

as a :mtter of record

mumtim.
The
My

EEG

mud

should not be

mama in any

study is going well.

best mgards.
Sincerely yours,

:1,-

Fink, Md).
meessw of Psychiatry
Max

:n

wwr

v
70.

:
r-x‘w»

Ml"
My"”gm"

«ﬂint-3'

'ma

l

30;“,

:'w"’€4&gt;".-W'H

W

mm

":1;

:kp

interim

�</text>
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                    <text>Jammy 10,

1989

Pitts

Dr. Nmaan

(has. Pfizer

8 (Emmy
Oameotiout
Gmton,

Dear

Harm,
Enclosed

.
«
u.

7.

‘W

w

told
as

you

v.w;...,-..,

y

v...“

and when

I

was

were in Europe, I canolated the report as best

I could.

mats , as always, will be most welcom.

also enclosing a revised protocol for the
definitive mt; study (12-30~68). The earlier draft
had some terms in the EEG and Clyde scale data which
are corrected in this draft. Please destroy the earlier
I

.,,,.-1-v.u—.~«_—-w

smmary requested by Mr. Fimxan.

I called your office for clarificatim,
Your

W"V‘R”,"V—“WHVV‘I’

is the

am

draft (Hemmer 29,
My

1968) and mplaoe with

this

copy.

best regards.
Sincerely yours,

”(7-1..WT,”

-7...

Fink, MD.
Professor of Psychiatry

Max

MFﬁcp

�</text>
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                  <elementText elementTextId="102830">
                    <text>April 21, 1969
Dr. Norman

Pitts

Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Norman,

.‘

Would

«my...

‘:uF?--mt,w~‘

it

be possible

for

us

to receive

3 x 100

are completing our Doxepin study

capsules placebo?
and I think this would be sufficient until termination.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
5;.

a;
«1;

1a
1*

“"1

MF:kp

war?

“55.13"”

’.“I'-F*£VW?¥'?"

aw

magewmwmmmr

gag/‘22:

~.
122;?

g;
y
‘,

ru‘vrn

-

\
wu-

V

..,'

”wan,

mama;

"1

W‘s:

Fl

�</text>
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                    <text>m‘ma‘TW-nrwow +r~w

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April 10. 1969

”lawn-Wm

ca
my

.TW'

{xix-w?"

Dr. Norman

Pitts

Chas. Pfizer 8 Co.
Groton. Connecticut
Dear Dr.

Pitts:
called to see

a patient who had obtained
from
a suppIy of doxepin
a “friend“ and had taken, at a
maximum 50 tablets. She recovered, but I feel that a summary
of this experience shouid be made a matter of your records.
In January we

Sincere1y yours.

.

,

w

“

'9‘V..u-:

Fink, M.D.
Professor of Psychiatry

Max
&lt;—‘v&lt;

In

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                    <text>n,»

«r

m.”

-

ngvr—

Aprll 3,

«m—

'r

2969

1—"

...&lt;.

.rv—w.

Dr. Norman Pitts
Chas. Pfizer &amp; Co.
Grotan Connecticut
Dear Norman.

Please send

parenteral

me

Doxepin

an additional 15 ampules of 2

to continue our

EEG

studies.

mg

Thank you!

Sincerely yours.
Fink. %.0.
Professor of Psychiatry

Max

MF:kp

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                    <text>May

28, 1959

Dr. Norman E. Pitts. Director
Department of Clinical Research

Pfizer

Chen.

&amp;

00.. Inc.

Groton. Connecticut 06340
Dear Harman,
on
I have rend the Hurstorio. Msggini and Hurri report
Subjects"
"Effects of P-3693A on the Night Sleep of Depressed
with much interest, having heard this report in Spain but failing
it all
to grasp the significance at that time. I appreciate The
report
doxepin.
the more for having our own experience with
of
sleep
with
recent reports
is good, and the data is consistent
doxepin.
with
EEG in depression and with out experience

Despite the repetitious style, the authors describe disordered
frequent awakenings
sleep among their depressive subjects ~ with
A as the principal effects.
3
and
and decrease in percent tine stages
with high dosage doxepin, within one week there is a reduction in
awakenings and an increase in deep sleep. The increase in
REM~tine is unusual, though probsbly drug related.
These changes appear drug related. The adaptation after 2
weeks is a possible problem; we would have wished some data in

weeks 4 or 5 of treatment.

discussion in relevant. The authore‘ distinctions for
doxepin from other drugs, while possibly true, is interesting and
data
reportable, but I would hove gishsdggﬁerg ggrgpggrgzsecure
be
few
to
for antidepressants and BOT. “wheaggporgopsre too
definite, although the results parallel the findinge reported
on
here for doxepin.

ﬁhﬁkb The

impressed by the dasgycoadyxanAAggsk that the dosage
be confirmed (it scene high); that if any similar data for week
should be reviewed; and what subsequent
a orwi ﬁlelxléﬂahday
studies (with dorspin or other psychoactive agents) have the

I

am

it
ant-hm W Amarmmywqiommﬁm
Enema-(memes
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Lﬂﬁﬂy hon

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Dr.

Pitts
Thank you

in our reports.

-2for sending no this paper,

28, 1969

May

which

will

bu

useful

I have received Itil'n notes

chnupununuugbnghﬁp week.

on CP 14-368 and will complete
The data of 8 patients in the doxapin

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                    <text>inw—wmzru

c

April l7, l970
Dr. Norman

Pills

Chas. Pfizer &amp; Sons
Grofon, Connecticut
Dear Norman,
In response To your requosf, I am encloslng ceples of our
Neurosls" and
report ”Lacfafe Preclpifafed Anxiofy in Anxlely
our Ielfer lo lhe New England lgyrnal of Medicine which has been
published. The Two roporfs by Ferris Pills are enclosed, as well
as The negaflvo paper by Grosz and Farmer.
Our work wiTh

laclafe provided us with

an

lnferosfing

opporlunlfy lo Teal fhis Theory of anxiefy. Wifh fhe awareness
fhal calcium can block lacfafe preclplfafod anxiofy, sludles of
known an+l~anxiefy agonfs such as doaepln would be very
My

besf regards.
Sincerely yours,
Max

Flnk,

M.D.

Professor of Psychlalry

Mszp
GOCS o

lnlerosflng.

�</text>
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,.

\\

g

‘

YR

,.

,vvmrgpu

September 14, 1970
Dr. Norman Pitts
Chas. Pfizer G Co.

Groton, Connecticut 06340
Dear Norm,
I have read with interest the proposed guidelines for evaluating
novel anti-anxiety compounds (received 9/8/70). Such an outline reflects

prevailing practice, but makes no effort to either justify the practice
as acceptable nor to highlight the hazards of our present practices.
As

on

a statement of present procedures,

special studies is interesting

evaluating methods

now

it is

acceptable.

The

section

and provides clues as to novel

under study.

Some specific comments are found on pages 3 and 4.
In the introduction, the marked paragraph may be omitted as gratuitous; and on
page 4, the section should be omitted since the NIMH—ACNP report is
and should not
a discussion of problems and issues, not guidelines
be so dignified, especially since the documents are not completed.
Would it not be premature for the PMA Committee to incorporate an
unpublished report before it is issued?
—

The initial single and multiple dose studies should be done in
paid volunteers, to assess safety and not in pagients (page 6).

qualities
that

is a statement that

would describe the steps
a potentially effective
trials,
The animal pharmacology which is used; the
(chemical and pharmacologic) of known anti«anxiety agents

What I miss most

leading to clinical
therapeutic agent.
seem common

and

criteria for

to this therapeutic group;

and

especially, those

For example, all
accepted anti-anxiety drugs are anti—convulsant, sedative (hypnotic),
produce seizures on rapid withdrawal and tolerance. But other
drugs have anti—anxiety qualities as various “anti-psychotic” drugs,
some anti—depressants, calcium salts and such,additional substances
as ethyl alcohol, opiates 33g,

aspects of present drugs that need improvement.

-

�Dr. Norman

Pitts

~.2—

September 14, 1970

In making these suggestions, I am reacting to the limited goal
of these notes - i.e., minimum guidelines for clinical assay; as
perhaps too limit33~?or industry. By broadening the document to
include animal pharmacology, criteria for early identification, and
suggesting that the drugs are symptomatic (therefore, not easily
categorized), PMA may highlight the complexity of the issues and
minimize the utility of 1970 issued, rigid ”guidelines”.
I am also concerned with the lack of supporting citations for
of the introductory statements. A detailed, academic presenta—
tion would be a more powerful statement.

many

Thank you

for the opportunity to read this

document.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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WW.w-m-.~._—w

-..

71

&lt;w"

A

“muwmw

September 10, 1970
Irrr—Jw

rum—“Wm“-

Dr. Norman

Dear Norm,
The doxepin pamoate

ww‘wwvl'v-v‘

~u-

2-w-wwrwwv—mmm-vvu-«w

W.

Pitts

Chas. Pfizer G Co.
Groton , Connecticut

protocol

was

revised following our

interesting discussion. I also found it advisnble to revise the
doxepin EEG report (IV: 7~21-70), 1 copy of which I gave you.
Please substitute the enclosed page 13, as revised, for the

page

is

5:1,

and no ”purer" doxepin

I was

your copy.

other preparation of doxepin has isomers in a ratio of
is aviilsble. For more refined isoner,
referred to Pfizer, Inc.

The

It was a pleasure to have you
expedite our studies this year.

visit,

and I

trust

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

we

can

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                    <text>August 3, 1970
Dr. Noreen

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Norman,

have completed the next step in the EEG profile analysis
of CP 14,368. In a comparison of single 250 mg oral doses in
male volunteers, we did not elicit a systematic EEG pattern,
although the usual behavioral and BBQ effects of a placebo were
we

inhibited.

Failure to

or the dose of

elicit

CP

the profile may relate to the sauple site
to the possibility that at this dose,

14,368 - or

its central effects

are variable and unsystenatic.

.

mw”

-ww-wn

ww-ymw.r'.

I an not convinced that the sample site is too snail, since
elicited a well defined profile with the same subjects in
another compound, under the some conditions. If the problem is
the dose selected, then we should consider a repetition of the
study at a higher dose or a multiple dose study.

we

I would like the opportunity to meet with Al ﬁeissman and
other scientists at Pfizer with an interest in C? 14,368. This
will make it possible for no to check my experiences with theirs
and provide the basis for recommendation.
I will be away until September 1. but would like to arrange
1 meeting,
that is possible, early in September. Separately
I am sending you three copies of the data books and the summary

if

report.

Thank you for your cooperation ind
examine this interesting compound.

for the opportunity to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc: Dr. Berger

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                    <text>August 3, 1970
Dr. Hermon

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Hermon,

Separately I as sending you three copies of the summary
report and the statistical data of the EEG studies of ore!

thiothixene.

s pilot phase and a preliminary
These data become the basis for the study

As you know, we undertook

profile study.

presented here.

profile of a single 10 mg dose of thiothixone is
cleerly defined, distinct from placebo, and identical for both
the capsule and concentrate formulations. The profile of
thiethixene is consistent with the sntipsychotic class of drugs
in our published classifications. (Ann. Rev. ﬁtment” 9:
The

EEG

241-258, 1969).

I went to thank you for the opportunity to undertake this
took much longer than I anticipated.
study and I regret that
much
and I am pleased with the outcome.
we
did
learn
However,
very

it

My

thanks for your coooeretion in this study.
Sincerely yours,

u
w

.&lt;.-»-

Fink, M.D.
Professor of Psychiatry

Max
"ﬂ'ml4lmﬂ'w’m”4m‘

VIM-vrmmw‘r

-

Mszt
cc: Dr. Berger

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                    <text>June 8, 1971
Dr. Norman
Chen.

Pitts

Pfizer

6

Co.

Groton, Connecticut

Dear Norm,

Enclosed are a few copies of revised pages of our recent

report,

”EEG

Profile Analysis of

Pamoete and B61 Formulations”.

Doxepin:

III.

Comparison of

I would appreciate your secretary
replacing the appropriate pages in your copies.
I an also enclosing our

compound which an EEG

two

reports

on GP&amp;1299, the Geigy

profile is related to doxepin.

Your report to the ECDEU was most interesting and I will
share the material presented by Dr. Saleburg with Don Shapiro
and be in touch with Dr. Saleburg if at all feasible.
My

best.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszt

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                    <text>». ‘7

‘

. _.w_.~..—.(.:~W

.—

—-W

m

v—mmr—w—r

'n-z-r

"F's!“-

May

Dr. Vorman E.
Pfizer 8 Co.

25, 1970

Pitts

Croton, Connecticut
Dear Horn,

\

associates, Hrs. Simeon and Spero, anJ‘I are
agreeable to having the reprints of our report,'A Comparison of
Hoxepin adn Chlordiazepoxide in the Therapy of Anxiety' distributed
to physicians by your professional representatives in the course
of their visits to physicians; or in the course of their replies
to inquiries.l/ we would request, however, that the article not
be used in the usual promotional material or quoted out of context
as a general endorsement of this product.
Ky

need,

You may,

of course, purchase the reprints which

bony thanks

you may

for your cooperation in this study, and
be useful to your representatives.

trust that the reprints will

Sincerely yours,
For Fink, N.D.

Professor of Psychiatry

mf/

I

�</text>
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                    <text>February 22, 1972
Norman

Pitts,

M.D.

Pfizer Pharmaceuticals
Groton, Connecticut
Dear Norman,

time ago, Garden and Cole asked us to

Some

assist

them

in the analysis of their date of a chronic high and low dose thiothixene
study. They supplied the tapes, we did the analyses. There were some
problems in the data collection, related chiefly to the copperation
of the patients and our inability to train the staff adequately. Hevcrtheleaa,
the analyses do demonstrate consistent EEG effects, similar for the high
dose thiothixene as
summary

I

we

am

found some time ago.

taking the Opportunity to send you a copy of the

report, for your information.
My best regards.

Sincerely yours,
Fink, M;D.
Professor of Psychiatry

Max

�</text>
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                    <text>”m my.WWW

«-

on»... “a...

r.

.7

v:.x-.~,n»m—...v.,.n-

w—q —.

we

"mm-a,_,.,_..ﬁ
-

.

,

WHWr-w-o ‘.,_.
.

.

sumwnu.‘
.

,

,.

“wry",uweu

.

"WNW.
.

7hSB—1188B
May

Prof. Dr. Antoine
LEHA

L8

1,

lQTh

Remand

Salpetriere

hT, boulevard de 1 Hospital

F—7563h,

Paris

Cedex lS/France

Deer Tony:

I very much enjoyed the discussions at the GEAR. You seem
surprised that we, in America, were already making direct applications
of computer methods for clinical purposes.
In my report, I lescribed two applications to clinical psycho~
pharmacology which are ongoing in my laboratories. At the same time
as I was working on this program, Prof. E. Roy John and my co-worker,
Dr. J. Valeria, were developing a computer—based Neurophysiology Clinic.
A description of their application
is enclosed as you requested. When
I inquired last week, I was told that they have a waiting list of more
than two hundred who seek this service.
EW'best regards.

Sincerely yours,

MF:ed

Enclosure

Max Fink, M. D.
Professor of Psychiatry

�</text>
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                    <text>November

Dr. Norman E.

8, l967

Pitts

Associate Director

Chas. Pfizer a 60.. Inc.
Department of Clinical Research
Grnton, Connecticut 06340
Dear Dr.

Pitts:

‘

study of Doxepln is continuing actively and we are
additional supplies. Would you be able to send us
of
Doxepln, 50 mg (100 capsules per bottle)?
l0 bottles
The

in need of
Many

thanks!

Sincerely yours,
Fink, ﬁ.0.
Professor of Psychiatry

Max

Mfzkp

Please ship to: Dr. ﬂax Fink
Department of Psychiatry
New

5

York Medical College

East lGan Street

New

York,

New York

l0024

�</text>
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Dr. Norman E. Pitts
Chas. Pfizer &amp; Co.

Groton. Connecticut 06430

Pitts:

Dear Dr.
We

are in need of additional placebo Doxepin capsules.
kindly arrange to send us ten bottles, lOO capsules

Would you

per bottle.

Thank you.

Sincerely yours,
Fink, P'1oDo
Professor of Psychiatry

MéX

HF:kp

�</text>
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                    <text>rw‘

an»

‘I'm"

Ir
-

n...

q-m-

—.

.»

up.

».

wmwv—q v-vsanw-w rum

m1’4m

"W_...,,

av" .

«n-u‘

,

-.

p

.
.. .w

avg—P? .. .,

.

7

YEW.) mm~

m.

7388:0993
May

Burton Angrist,

M.D.

York University College
550 First Avenus
New York City

New

5. 1973

of Medicine

Dear Burt.

I

have rs~rosd your
interesting. I an vriting

report on CLllo,393 and find
to raids two suggestions.

it

most

In your experimsnts, you seensd to allow the sessions to
proceed for many hours; and in the discussion you note that the
was this
effects of this compound could be blocked by noloxone.
2
The
implication
effect tested in man 2 sad. if so, did it block
wonder
why.
and
I
not
was
tested,
was that it
The similsrity of this compound to storphine is indeed
striking. Tvo years ago. when I became interested in very potent

use.
opiates, I obtained a supply of storphine, which I did not
nsture,‘
similar
of
a
undertake
sons
trials
to
I would have no hesitation in supplying s fsv mg for your use.
My thanks for letting me rend this interesting rspbrt.

Should you wish

Sincerely'yours,
Imumm‘mvc’

'I-I-‘W'W-w—awv-w-w

1‘

""Wwvwrw

5"
‘
"~

‘
"'
"

'
“m"

mm:

“ain‘t-u

uwvr

wn-

wr

Ms: Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>,, "w

Mm",

”wan-n. ..-.

V

“.15... ‘3wmwmm3v-yh-y‘nww.h”7; .m .._. v

.fiwrvyn—rm—J-nnm

—..~

._...a—h———w-—s—Wu

"HA-t

-

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.-

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..

V

n

~

.m

&gt;m

v.7

--_

..:—v-~.~~—

7383~78083

19 Huvamber

1973

wry

'
:0

-ruywn':mm1v.mvs

.

M B H

0

R A

H D U H

To:

Hr. Jurgnn Krnuﬁc. Associate Ditcctor of Personnal

From :

Max

Subject:

Tuition Waiver for Peta:

Fink. M.D., Profnsoor
M.

Irwin, Spring 197k

Encloscd plans. find the Tuition Haivnr form for Pater
Irwin. Mr. Irwin in ruspansiblo for extannive data manly...
gauorncoi by our ongoing psychiatric cvuluations. 30 use:

facilities on campus for thi: work, and he £ta~
it unca-sary to modify programs and sclcet up.
propriata ctatistical procuduxcn. His atudics in computer

cha computer

quantly find.

at. ditcetly rclated to his work in this departmant
will unable him to pattern his dutica in a morn sophisti~

sciences
and

cared Ind preciac manner.
Your prompt

MF/cis

Encl.

attention in this mattcr will

bu apvreciatcd.

,

�</text>
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                    <text>wwwmww'n’mww

'm‘mm

Hum-er

-

Wiewl‘m’v'wxum'mwr'zs-v

WWW
,

rnxmvpmvvurv-wv;

«nun..- rrmw ~l4—1Vauvs-nm‘w

,

,

w4my

Septenber 28, 1970

'U-vwr'rll'r

“wanna":

Dr. Virgil A. Place
Ales Corporation
950 Page Mill Road

Pele Alto, California 94304
Dear

Virgil,

The prosteglendin sessions were most interesting and I
went to thank you and Peter for bringing them to my attention.

Enclosed

is the marijuana pro-print

study is not yet in press.

you requested.

The

In reviewing data in my files on the relative potency
of antipsychotic agents, with a view to their use in 1 long
acting formulation, 3 table of relative dsily dosage ranges
shows the following:
Fluphenazine
Buteperezine

w

Trifluperesine
3Wf—WWWWWHVW

Thiothixene
Relaperidol

Stelezine

Nevene

Haldol

5-40

10-60
15-40
10-40
15—45
2—4

we

look forward to hearing from you.

Sincerely yours,

N‘WWWHYWW'W'HG

‘

”‘e‘

Fink, M.D.
Professor of Psychiatry

Max
W;

THE

M?:kt

_

.'

‘

H

V'w,,n,.

(mg)

Serpesil
I have selected representative drugs of different chemical classes
from s larger table.
Reserpine

‘-'

Prolixin

Repoise

�</text>
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                    <text>v

,- ~wwmm~zv~rvo~w

.

\\-'€-(Mw.Vaalvm'

.

-.-.- Fwy-n

mmv «sh-w" "'lr'x'

.

»

w—w-n

rnr-v

a—

wva..-..- . r.w--ew'.w-'W a... ".17...

:w

l 1..."...— ‘NW “c.

-:

i,

r-.."

November 23, 1970

Va.-

l“-‘.v1y‘~‘

——-. (-u-r.“ ”VVW—gw

Virgil A. Place
950 Page Hill Road
Palo Alto, California
Dr.

Alza Corporation

Dear

94304

Virgil,

I appreciate your interesting suggestion for the development
of a long acting antagonist. As you know, there is a public
committment to methadone, and it may be difficult to achieve the
requested level of support immediately, but I an optimistic that
the interest in antagonists will be re—awakened.

it.

1)

My

associates

have read the proposal and we

will

2) A copy has been sent to Dr. William Martin, for
and comments. Re is on the appropriate NIMH committee.

recommend

his support

will be included in our l971«72 contract renewal
York State Narcotic Addiction Control Commission, for
review on or before April 1, 1971.
3)

with the

A

summary

New

I have read the Alas annual report _ 1970 - and wish to support
your efforts in developing more physiological release forms of
psychoactive drugs. Our interest in the antagonist is part of a
broader interest in the effects of drugs altering the CNS for
prolonged periods for therapeutic ends. In 1964, fluphenazine
enanthate was the first formulation that provided a solution to
the problem of recidivism in seemingly successfully treated psychotics
patients who responded rapidly to treatment and relapsed when they
felt so well that they "forgot" to take their medication. In
numerous studies, many in our laboratories, this formulation has
been successfully applied in patients now in continuous treatment

for

3—4

years.

~

._

.3.

�aa,..mwnv-.N.Wy

—

‘

-2-

Dr. Place

There

It

may

next you

November 23, 1970

is a need for similar formulations for snt1~psychot1c,

anti~epileptic

and

anti-depressant drugs.

be useful to discuss such needs and

are in the East.

applications,

Again, my thanks for your presentation, and I
submit it for support.

am

Sincerely yours,

«-

v

amw‘vv

Max

'1rmnmmmmuumu-mm—v

a
--

'4-1-W‘r

I’l-n:w'lmwrn~iuplnv7—Y

.fF-"wv

-rnrwrvrm-.wrmn

mus-.W-mm-u—M

W"m~’3."'“

-wﬁwyr

Fink, M.D.

Professor of Psychiatry

«w:

Mszt

_.

when

pleased to

..(.,V_-.......r\

"pen-.5

�</text>
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                    <text>January 27, 1971
Dr. Virgii P1ace

A1za

Corporation

950 Page Mi11 Road
Pa1o A1to. Ca1ifornia 94304
Dear Virgi1:
Fo1lowing the intrusion of New York City into the search for
a 1ong—acting antagonist, a 1ay organization. FADA (Federation
against Drug Abuse) announced its fund raising program focussed
on a “positive" approach to drug addiction. They became interested
in the antagonists and invited the participation of our 1aboratories
in their scientific advisory board. Their fund raising is showing
that may be usefu1 for us
sufficient promise for me to suggestNew
York.
in
when
next
are
meet
you
again,
to

it

.

y
.

“1.-..

.7";

Hou1d you ca11 me

-_

;

-~.-.v.-;v.

,.4'

My

before your next

trip East?

best regards.

nu,.-q-;u-y:p,¢«,rapw

Sincere1y yours,

57

Jul-"ha

ﬁrm;

my“

Fink, M.D.
Professor of Psychiatry

Max

4'
.

Mszt

�</text>
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                    <text>'wul‘w-Pw-mw—w

7383693

m-e—

«WW.am.

“m-‘m'ﬂn‘ﬂ’vwx.m~vv..,.v..w

June 13. 1973

Professor 2. Keohoulan.
Dept. o: Netursl Products,
Hebrew University or Jermain.

The School

9.0.

or Phermeey.

B. 12065,

Jerusalem. Israel.

Deer Rspheel .Both Al and

I

I were distressed by your letter of

may

30th.

letter of Her 10th indicating that you
in the States for s for days, but during thst time I
see in Mono. end therefore did not reach you. Your lster letter
is inaeed surprising, and I very much rep-at thst this sequence of
events hes mom-red. Ae you elresdy know. the Netionel Institute
of motel Heelth with snow widen“ he‘s finslly end reluetently
eased to maerteke s. program of. developer“: of e longnseting
sntsgonist. There ere new contract sppliestions, I on told.
end perhepe the eonittee will arrive at a. legion]. decision bssed
on the credentials supplied by the Northeastern poop.
I believe that Al will note some mention of your distress in
his next discussion with the people st
had rseeived your

would be

m.

m.

wit
It is of interest to use that may
experience
or interest in drug abuse have indeed cone into e field during
the pest two veers . end new with fine reputetions have written

moire great sppiieetions

which committees

,

st

m hsve funded.

I hove been saddened by these events. in yertieulsr b1 the menses
that new who heve come for monastery gain will probsbly contribute
little. Also. because there is so mob honey, science seems to
here been dieplsned by polities. Beosuss I here been becoming
increasingly Wfortsble in this environment . I have foenssad
more of w sttsntion on the problem of herein and behavior.
particularly with psychoactive substsnees . and put the drug sbuse
problem sside.

‘

Our studies of hashish users in Athens is going very well,
end Dr. Btethnis end his coworkers should have s creditable

doemnt demonstrating the leak of signitiosnt effect of chronic

..

- .—.

"mum-e...

�Pref. a. Micheal”:

~2-

June 13. 1973

Mill:
an. Ind 32: mm degree of tolerance to very high
doses of mush. (Men make 130 I; arm-mm equivalent
fam- tilu t «hr with plum. and without intmuption of their
par-fame).
I hope than will be tn opportmty to visit you in
(formula some time soon. In 1:11. m1}... should you cm
hack to the Unit.“ Stat.” plan In no km. and whap- to
em ”man to have dinner
My

bent--

”my“.

W3

Mum»
‘

”/13.

"

,:

yam-n,

Fink. 1M).
Fatwa: of thn’ary
lax?

�</text>
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                    <text>February 22, 1972
Dear Dr. Plstcow,

It is quite

I have read the section

good, and

my

on

few comments are

antidepressants carefully.

listed in the margins.

I would suggest that the sections related to the presumed
effectiveness of the MAUI be reviewed, for the available data is chiefly
uncontrolled testimonials. The list of dangers is well documented, however,
and the contrast sufficiently great for us to have eschewed the use of these
drugs in our treatment programs. Indeed, the risks are as great as with the
amphetamines, and perhaps the same cautionary tones should be encouraged.

Recent evaluations of convulsive therapy, particularly
with the modification of unilateral ECT, with succinylcholine and
Brevitsl, show this technique to be 80~9OZ effective (and safe) in severe
depressive states. Perhaps the Council should review the whole range of
therapies listed under 'antidepresssnts', and introduce a section on ECT.
This treatment is surely more effective and safer than the amphetamines
or MAUI. For a recent comprehensive review, see the February issue of
'Saﬁfﬁafg {M organtatﬁy; published by Grune &amp; Strstton.

these notes

may

Finally,

may

give in the

I ask that

list

you acknowledge the

of acknowledgements

? Many

little

thanks.

help

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Mex

�</text>
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                    <text>March 8. 1971
Dr. Edward L. Platcow, Ph.D.
Department of Drugs
American Medical Association
535 North Dearborn

Illinois

Chicago,

Street

60610

Dear Dr. Platcow:
As

requested, I have read proposed chapter

It is well written

are few.

and

authoritative,

32

"Antidepressants".

and my comments and suggestions

Pg. 32$) Paragraph 1: Recent notes suggest that thiothixene
(Havana) also has antidepressant qualities. We demonstrated such
is my impression that Drs. Norman
activity in our studies, and
Pitts and Allen Borger at Pfizer Laboratories, Groton, Connecticut

it

can provide the available documentation.

Paragraph 3. The role of ECT is presented in too limited a
fashion. In every study of ECT and antidepressants, ECT is more
effective and more rapidly (see Cole and Davis, in Freedman and Kaplan,
"Comprehensive Textbook of Psychiatry“, 1967: 1263—1275; Klein and
Davis. Diagnosis and Treatment of Psychiatric Disorders, 1969: 187~322).

important, in suicidal risks, involutional melancholia, and
psychotic agitated depressives, ECT may he 1ife«saving, while antidepressants are too slow and ineffective. Although drug evaluation
is the focus, in my view, ECT is a complex way to achieve a biochemical
change in the CNS ~ which is, after all, the goal of pharmacotherapy.
Most

Paragraph

Too harsh an evaluation. The
show many controlled studies.

&amp;.

Klein and Davis

Paragraph 5.

depressions.

A

references cited by

reason to emphasize the value of

ECT

in severe

Pg. 259, Paragraph 1: English syntax is poor in phrase, ”..., since
these agents block the actions of these antihypertensive agents".

Paragraph 3. The duration of drug effects is generally 48~72 hours.
The recommendation of a 2~week interval between tricyclic compounds and
MAUI seems much too harsh, and too restrictive.
Probably 72 hours are

adequate.

�y‘)

Dr. Platcow

March 8, 1971

—2~

Paragraph 9. I do not know the evidence for restricting
imipramine in epileptice. My own data suggests it may reduce seizure

activity in the brain,

and may

therefore

be recommended.

the data source be checked (see Canad. Peychiat. Assn.

166-171, 1959).
A

J.,

I suggest

6(Suppl.):

restriction omitted is the use of imipremine in schizophrenia,

where excitement states may be precipitated
Plenum Press, 1965, 1; 53-61).

(in Biological Psychiatry,

Pg. 260, Paragraph 2.

Same as ?age 259, Paragraph 9.

Pg. 261, Paragraph 1.

Sinequan

is

now

prepared as a concentrate also.

Pg. 262: Nialamide, and Phenelzine: Efficacy is suggested in
endogenous depressions. The evidence is clearly that such patients
show no response to HAOI, and if there is any application, it could
be in the neurotic depressives.

Tranylcypromine. Same as for phenelzine. Surely, there
that tranylcypromine has been effective over ECT. I
is
would doubt that there are cases ”inapprOpriate for ECT” [such as?) who
may respond to tranylcypromine.
Pg. 263:

no evidence

I trust these

comments

are helpful.
Sincerely yours,
Fink, K.D.
Professor of Psychiatry

Wax

MF:kt

V

.ww‘ﬁw

~v—w.

:‘.’l.‘,‘

WWW”

93¢)Wmm-

Wit-5.

"at

wa-MW

�</text>
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                    <text>November 28 , 1965

Plenum Press
227 West 17th

New

York,

New

Street

York 10011

Gentleman:

Bmlosed

is the official University of Missouri Purchase

for the mpﬂnts recently requested by m of the article
"Thu Classificatim of Psydzoses by Quantitative EEG Mew"
which will
in Velma a of Recent Advancu in wag/Luz
Order

PAychiang.

W

Sincerely

ym .

Pink.
m
Professor of Psychiatry
MOD.

HF:kp

�</text>
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                    <text>October 19, 1962
Mrs. Gloria Podrid

Hillside Hospital

Po 0‘ Ba 38
Glen 0&amp;0, New York

Dear

Gloria:

I

have an opportunity to discuss the tub-hospital study early next
If you have the gamma of the paper "Sociopeyahologieal Aapacta
of Psychiatric Treatmnt in Three Voluntary Hospitals",
you be
able to run of: 50 3091039! ate}: of the tablet, luvs, and and than to

month.

m by

mid

“war 5th?

.

far we have not heard whether this piper has been accepted in
publication and I have may om copy. Dix! m mks a “email a: a draft
appreciably 1713/62? If we did, would you and In about. 15 copies?
It not, no if you hue my othor lanai). of this paper and it it it:
So

not too early 3 draft, could you run of! 15 «pica?

Swarm-1y I have» aunt. Don min the paper for Psychophamealogia
uhieh has hen accepted for utilisation. here are some mowed
oditarial
dbeniae toauadtotha oditm-sanw
nopy with amateur «summations he ukau. You light can
by getting his approval tau.- nking a Mail, and naming the two
803316! the «liter wiphos from the stemmed version. If no, aauld
you plum and m 10 capiaa?

Wtwit

mum

'

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manna,

If there in am rowan not to Mb 11 stencil
perhaps yen could do this in your lawn time over tho next few week».
Thank you very ml: for pending the :dditional eopioa at the book to
Dr. Bogthilet. Did you have any luck with a. tuner on the first package?
Simrély yours,
MISSOURI INSTITUTE OF PSYCHIATRY

Mu

Fm,

Director

Address correspondence

to:

Shoo Arsenal

M.

D.

Street, St. Louis 39, Hiawuri

�</text>
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                    <text>”u“.

October 22, 1962

Mrs. Gloria Podrid

Hill-idly Hospital
P. 0. Box 38

6101:

Mo,

Now

York

Dear Gloria:

list of the people to whom we sent the bibliography?
you did, then either send the list to me, or, if you have some
the,
would you send the following note to each om?
If

Did you keep a

"I

are

the

plotted to

tell

monogram of

1963.

that Elsevior has owed to publish
thOphamoology early in
that I brim it up to date for 1962.

you

EEG

Tiny have gained

and Human

If there are related references which we have omitted, would
you please send than to
shortly? Plans 111ch any
refer-anon which may now be in press and which you expect.

u

very

to appear 1m in 1962. or early in 1953.
Thank you for your cooperation.“
I would upptooiato 1: you could do this for

nah.

me.

Thank you

Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

M,
Director
MD:

mun:

Addreoe oomopondenoo

M!

D.

to: MAI-canal Street, St. Louis 39, Missouri

�</text>
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                    <text>October 16, 1962

Mrs.

Podrid

Glam-1a

Hillside Hospital
P. 0. BOX 38

Glen Oaks,

New

York

Dear Gloria:
Hy reprints are still in boxes and we have not had an
apportuniﬁy to upon than. Wauld yum please send the reprints
reqnostad to Dr. throa?

Sincerely'ynmrs,
MISSOURI INSTITUTE OF PSYCHIATRY

Max

Directar

Manw
o

Fink,

2c,

L

mug

0;:

Addrala correspondence

\M.

to:

.

v

M. D.

4%,)

Shoo Arsenal

Street, St. Louis

39, Missouri

�</text>
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                    <text>August 31, 1962

Mrs. Glorla Padrld

mm

of Expulmml Psychlcmy

Hlllnldo Hospital

75:59 263ml Strut

G-lm Gala; Ncw Yul:
Dad! Glorla

2

Plans. sand

to:

Dr. Walter Knapp, Celumbu Psychlcmlc

Unlvmlly, Columbus 30, Okla, the follawlng

refs-mu:

lmlMo, Stat.

60, 57, 53, 37cm! 34.

m

Also, Wmmhed coplas cf the
papers by Don and myself; pattern;
wlth chlarpromzlne and paﬁerm wll-h lmlpramlna. Also a mlmeoaraphod copy of the
lamt EEG in human myahophamoology, 3, by myself and Andaman. Include aka
a blblloorapby ( EEG and Human Plychophwmacology, ”514961 ).

~.

‘

,

'

a mess.

See you Smemlm Nth.

I

,

can't get than out of my own fllu, slnco they can
.

Slnceroly

yam,

Max Flak,

M.-

D., Director

Mluwrl lmlMc of Psyehlatry

�</text>
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                    <text>June 13, 1953

Mrs. Gloria POMd

Hillside fbspital

P. O. Box 38
Glen Oaks, New York
Dear Gloria:

mt
studies.

I amsum theyare somtmminmyfilas, I
findacopyofthe "WardRatim; Scale” ncrofthe "Johnsfbﬁdm
While

Symptom

If

Scale” as

in the

1960.

drug

or two copies of

cam):

in

we used them

you have one

please send them to

me.

yoxm

Thank you.

Sincerely yours,
biax Fiﬂk . MOD.

Dimctor

W33?

cabinet,

�</text>
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                    <text>June 13, 1963

Mrs. Gloria Podrid

Hillside Hospital

P. O. Box 38
Glen Oaks. New York

Dear Gloria:

Welmszmé"Ward
ﬁreyamsamrnminmyfﬂea, I

find a copy of the

8mm Scale“ as we used ﬁlm in the 1960 drug
If you

have one or: two copies

please sand than to

1m.

studies.

of each in your cabinet.
'

man}: you.

Sincerely yours,
Fink,
Dimmer

Max

Hfzjr

canmt

Rating Scale” nor of the ”Johns Hopkins

PM).

�</text>
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                    <text>April 23,

Miss Gloria. Podrid,

Research Depu'tmmt

1965

Smtary

Hillside Hospital
P. 0.

Boat 38

Glen Oaks,

New:

York

Dear Gloria:
no
be

if

IngoingtlrmxghsomES‘ralidos. Ifomdthmewhichlnd
oaptim. Since the slide gives an the m; umber, I would
gmtefulifyouwouldomdcyourfiles to
still available, for tho following Hillsidefindthemport,
Hospital EEG

Rom:

Iii 1392

HR 148%

Hi

RH
HR
HR

11:86

15%

1572
1597

HE 1599

that
who
1957.

.I beliow that the moorcb will clarify the
were placed on the slides whim I believe are dated
My

best regards.
Sincerely yours ,
Fax Fink, H. D.
Professor of Paydmiatry

Hfzkp

�</text>
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                    <text>W—v-w

.

v—v

~/-v

memgr

October 18, 1962

wmrww.M~—vwrqu,m&lt;vn~,-,mwm-m—lu-mm.~vgwm-WW

min—w

m""m

Min Bomis

Pun

Bachrach Photograpl'ara
ha Eat. 50th Street
New York 22, N. I.»

Dear Miss Poe:

Immrrythntlhavetmldﬁmee upsolong,but1nlv
manganywen
atmmmutwotwmru Ihm
hpt. ’62:: numbers of that: picture: that are of greatest interest
and m1 tron him to time wits to you regarding additional
prints.

Thmk you

for your cooperation.
Shear-«13‘

you“,

MISSOURI INSTITUTE OF PSICBIATRY

Mm...

MIX

m’ H. D.

ww-W—Iv-s-

Adda” correspondence to:
'1'“

shoe

Arum Street, St.

77/2?- A2,,

7 7/57 m M?
77/? - / &lt;/ (mwgémy J
.

Louis 39,

mama

�</text>
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                    <text>April 10,

1965

R. C. Pogge, H. D.

Mica). mmctor

Dorsey laboratories
1:1an 1, Nebmka
Dear Dr. Pogge:
Dr.

diseasedymmletteroprril 7.can
Itilmdlhwe
of Investigator so that you
Statemnt
the

I an missing
pmcess this.

that we cmsider eight subjects to be studied
must
betwemncwmdﬂsy Sasapilot studyisemcmblerequest,
Your

difficulty in fulfilling at the preamt
tine. Inouhrtocmoutsmhastwy,wewouldhaveto
session
select the volunteers. provide for an initial mooning
establish
and
the
acclimated
test
to
sthim
so that they as:
a set of m; discriminmt criteria for this canpomd. waver,

but:

cm that

we may have

assomaswemdertakethesesteps,wemineffectmdertaking
a definitive project.

W.

have reviewed the data on Pymvalem which you provided,
dated October 196“, md the report by Dr. Hollidey in
We

Itiseppmthatﬁzismmxddoesheve

ectsan itwesmn‘beliefﬂntwrutisneededatthe
pmmttimeisadetemimtionoftheametmcomecfﬂds
other central
effect, using EEG criteria, md a miss!) withdefinitive
study.
would
a
require
To
do this properly
stimlants.
Wewouldbepleuedmplmsudxastudywithyou.
can

e

‘

Sincerely yams,
D.
m
m,
of
Professor Psychiatry
M.

�</text>
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                    <text>August 21, 1965

Dr; R. C. Pogge

Medical Dimctor

Dorsey Laboratories

Box 1113

Lincoln, Nebraska 68501

Why:
Your letter of August 6, was received while I was on
which explains the delay in wavering you.
You

vacatim,

are quite correct that Figure 1 might be interpreted as

you suggest. However,

associates and I have indicated that
some pmblem in behavioral cmtml
believe we am nomcting these in the
my

this progress report mflects

and EG sanpling.

present study.
We

are

We

now completing

the data analysis on two volunteers

testing diffmnt behavioral control davioes . Within the next
few days we will lmmch the definitive study, and we trust that
we have pmvidcd adequate controls for some of the questions
raised in our pmgmss mport of April 1965 .
With regard to ycur visit'on Monday, October it, I regret
that this is a difficult tim for us. Dr. Itil is scheduled to
return from Europe on October 2, and I am scheduled to be in
Comecticut on October A and S.‘ I cmnot check with Dr. Ulett
as he is on vacation. I would suggest that October 12. 13 or In,
an pnfcmble dates for us and both Dr. Itil and I wmld have
more tin available on October 13. I trust mat this will be

agmeable with you.

Sincemly your-s ,
Max

PM,

PM).

Professor of Psychiatry

HF:kp

cc: Dr.

Itil

Dr. Ulett

�</text>
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                    <text>October 29 , 1965

Mr. Oliver
A. G.

hamburg
S

St. Louis.

mum

nos

2mm
North 8th

Sons Backers

Street

Dear Mr. lmgonberg:

in

Immtvezymmmatthekmmlmpomwas mentorII. I have taken the liberty of correcting this

Appendix

1111891111
mdmsmdingymaoopyofﬂommdmport.
be distributed to each of the mixer members with the minutes.

Immlosingﬂmbmkfommwoulqumtthatyou
and each of the resolutim foam on

sign each of the

linen.

cm

81:203me yours ,
Pink, M.D.
meantime Director

Max

Mftjm

moles

�</text>
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                    <text>April 1,

R.

c.

Hndionl

1965

W

"O D.

Limoln 1, Nebraska

Burma Pow:

Dr.ItildehavomletedmmsmveyforSKFandm
mathods

believe that our

are suitable for the kind of analysis
ycumquutod. Inmdertomrkmtafmlpmtocolmto
mhownﬂambemliﬂndbofmﬂndeadlineofﬂay 8,
thatyou
tedinymmmemtlotter,m1dyoubeableto

canardvistm?
Isimuldbeavailableanofmxtmkmdmlu,but
findthatlwillbeoutoftomfmthetlﬁr'tmthtotho
sixteenth. Any other film

bothDr.Itilandmyself.

this

month

will be satisfactory for
.

Sincerely yams,

m
m’ D.
Profussm‘ of Psydxiatzy
M.

�</text>
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                    <text>”member 2, 1965

m.

R. C.

Poms

Medical Director
Dorsey Laboratories
Box 1113

Lincoln, Nebraska 68501

markay:

initial dismsims in June,
preliminary protocol for the Dorsey-£93 study.
Following our

we

established a

It was our purpose

to measure the EEG changes induced by 1cm dosages of pyrcvalsmne,
and to mare the
with placebo for a prospective study
the changes th those induced by mhetmins. Our initial
trials were with 30 m and 60 mg pymvalerme. mess (bosses were
selected as We related to the clinical state Whidl interested you
and Imioh was similar to the studies published by Dr. Halliday.
In View of the problem of behavioral control in our first
study, we decided that the initial trials (hiring the smr would
be varied with regard to the mum of behavioral control.
For

this

purpose

we

selected a reaction time model.

Four subjects were

initially introduced to the study

program

it necessary to vary the behavioral pamtem,
two of the subjects were exmed and await the definitive study
itself. In two subjects we varied the behavioral pmters and
foam of eminetim in numerous trials.
but as

we

fund

Initially, we studied the effects of a cmtinuous performance
task with the auditory signal applied on e mndm basis thrmglmxt
the four hom- ssssim. In later trials we mod the stimulus on a
block basis and by the and of our experimental studies decided that
the best control was provided by ten stimli presented every 12
minutes. The stimlus is a 1000 cps signal.
undertook tumty studies during the two and one-half south
sumsr period and of these , thirteen are satisfactory for our present
initial analyses. ”these are equally divided between pymvalerone
30 mg, pymvslem 60 mg, inactive placebo and m active placebo
We

(papevwinediks contra. vasodilator).

EEG

were recorded.

M

lead oombimtims for

'Ihe EEG analyses were mcbr'taken

principally

for the occipital—frontal lead destinatim, but in four records ,

the bi-frmtel leads were also studied.

�Dr. Pogge

November 2, 1965

~2~

lbs effects of the active placebo and inactive placebo were
indistinguishable in the later behavioral controlled experiments .
In the experimsnts earlier, when the stimulation was continuous ,
subjects failed to respond and developed drowsiness and in one
instance fell asleep despite the stimlaticn. In the later
exparimants , the periodic stimulation provided better behavioral
control and the EEG variables did not show changes beyond one
standard doviatim from the pre—traatmnt record.
Both the 30 mg am: 60 mg pymvalemne dosages demonstrated
changes in average fmquenoy whim was prominent during the first

hwmdagainduringthethirdandfourthhomsofthe experiment.

In each instance the average fmqumoy appeared to increase so that
the records showed periods with mom than 1 1/2 standard deviations
shift from the pre-tmatmt baseline. The observations were
cleaner for 60 mg than for 30 mg doses.

,

The changes induced by pymvalem were smaller than those
induced by bazbitmmtes on visual analysis, and the variability
appeared to be water in these, two subjects. As a consequence,
we feel the changes in fmquencies ad in average frequency mich
may distinguish pyrovalcmne foam placebo will be observed only
for the group data using the statistical techniques which were
successful in the barbitm'sto study. For this masm, so are pre~

pared to undertake a full trial of pyrovalamne against placebo
in volunteers , estimating that 12 subjects would be the initial
population for malyses. The behavioral cmtrol in such a study
should follow the experiences mien we had in tho latest experimts.

of this review were sumarized in a protocol dated
its modificatimwﬂmber 1. This protocol moompassas
your momdations, cspeoially with regard to dietary control. A
”the results
10—21455, and

copy

is enclosed.

'

~

While the 60 mg pymvalerme would probably give a better
discriminatim than placebo, we are preparing trials with the
30 mg dosage form to provide data which is comparable to that of
Dr. Halliday. If this protocol (10-21-65) is satisfactory, we
mold be pleased to undertake the definitive study.
“thank you very and:

for visiting our laboratories.
Sincerely yams ,
Pink, M.D.
Professor of Psychiatry

Max

Hf’mp

�</text>
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              <elementText elementTextId="19992">
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                    <text>‘

,4

_,_

....&lt;,‘

May

I
-,
‘

31 , 1966

,A

,

A

.;-_-.v...-.-.,V.

an

«53-

Raymwd C. Posse, 11.1).

Medical Director

.n,

"Friar-m4-

5"“de

Downy Laboratmdaa
Box 1113
Lincoln, Nebraska 6850].

Dow Ely:
”WW-mm‘wv

Thank you

awkw-

arm-n

for your letter of

your suggestion, all
have been dostmyed.

,

available

Wm

ﬂay 28, 1966.

mplies

of

Following

Shmmly yum,

if'ﬂ-‘K—J

awn-wan»;

saw

Mu Fink,

reg-"4',"

vamrrwt-W

v

t
gm
—

magi-mu;

ray—urn

"a
.

ma

"tiﬂmmwwﬂ'wrvmazwa"?7§‘?h’-v:.,;;’:»q.u

7:

"Iva-ﬁwrgym

et.»-

My!“WmEJAW£Ww¢mmwmggmr

.-

‘1)??5‘75

fojnh

24.x).

Professor of Psychiatry

�</text>
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                    <text>May

ll,

1972

Miss Candy Poinior
Colby College

Wotarvillo, Raine
Dear Min:

It

Poinior:

like I will be unable to visit Colby College
this
I am willing to offer you an opportunity to work
in this laboratory as soon a: school is over:
now

looks

month, and so

In

New

York

until

September/October.
a Research

we nova

to Stony Brook in

Technician at $7,200/yoor
in training. plus the usual perquisites of
fringe benefits (Blue Cross. insurance. holidays.
sick leave, etc.) of the College now (and the
comparable at SUNY—Stony Brook in the fall).
As

return .

Enclosed

is

on

(EEG)

application form; comploto what

you can and

I look forward to mooting you.
Sincerely yours.
N.“ Pink, PhD.

Profoloor of Psychiatry

HPxig
ﬁne.

�</text>
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«NWT—“WWW“

.

March 28, l968

Dr.

Phillip Polatin

York
722 West

New

ﬂew

York,

Dear Dr.

State Psychiatric Institute
l68th Street
New

York

Polatin:

for thinking of me and sending me
the historic report of organic mental reactions during shock
therapy. This is a historic report, as it was one of first
Thank you very much

which communicated the

EEG

changes seen in these treatments.

first

teacher in EEG and I one
of my present interest to the enthusiasm which he
showed during my learning period in 1952—53.
Hans

much

Strauss

was my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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Dr.
New

Phillip Polatin

York

722 West

ﬂew

York,

State Psychiatric Institute
l68th Street
New

York

Polatin:

Dear Dr.

Thank you very much for thinking of me and sending me
the historic report of organic mental reactions during shock
therapy. This is a historic report, as it was one of first
which communicated the EEG changes seen in these treatments.

Strauss was my first teacher in EEG and I owe
present interest to the enthusiasm which he
showed during my learning period in l952—53.
Hans

much

of

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>11

QIMiP

M

”numz-

A

20 ,

196“

Poling
Sales Hamger
Research Division

Mr. Floyd

Industrial Naming Madam Corp.
Harman,

mar

New

Jersey

Mr. Poling:

for your recent imuiry to Dr. 8Gemhon. The contract,
not
incerpmting your proposal issul-l, 2, 3, has, as yet,
such
that
Missmmi.
anticipated
is
of
Itand of
been let by the State
At
time,
that
April.
the
be
harm
simd
a Grommet will
informathe
would
mlease
Mr.
John
Paula
of
the office
I

Thank you

mt

ticm of the successful bidder.

Sinoemly yours ,
Max

Fink, NJ).

mmcmr

MF/jb

�</text>
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                    <text>Kay 18, 1966

Mr.

Irank Polk

2607 Boson:

Strut:

Borknloy, California
Door HR. Polk:

ago. Milton turner, ESE, at Oakland, Colltornla, has spplicd for
a pooltton as u_RnI¢ar¢h Soelol works: at thta instituto. Tho
proton: programs of this lultltuto are dovoted to ntudiea of the
lovnro unntnlly ill and spaclfle ineurcst is being placed on
docoralnlng tho ﬁhyatologioal. pnyohological and social factors that

contribute to proloogod hospitalization

and

trnataont failure.

In toctal-vork, no are anxious to bar. workers who are :blo to re—
lnco to familial and to bozo the paelouts return to the community
as aorly at possible. In tho lotto: role, it in important that
our nanooiaton be ablo to work with community ascuotel, family
lumbar: Ind the various ruhabllltatlon and work servicoo 1n the

Wt?!

gratoful for your opinion as to Hrs. Farm-2'. abilitieln this $03.24, on wall as any information regarding her training,
oxyotionco and her ability to relate to tho cover: nontully 111
and also he: ooduotkora.
would ho

Thank you very much

for you: oooporatlon.
Sinoornly youra,
Ha:

rink.

Dirootor

HIIJb

H.D.

�</text>
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                    <text>October 17 , 1962

M. Ma: Pollack
Hillside Hoapital

P. 0. Box 38
Elan Oaks, New York
Dear Max:

It no

11199 chatting with you yesterday ottoman. I shall,
few days, make
the
within
not” regarding tho program
here and and it. on to you.

m

wt

Enclosed is a atatomn‘b tron tho Senator Gluten This
should be charged to M'! 2715 except, that you my approprintoly
charge ans-halt of tho $h00
to MY 2:798.

wt

Ishouldlihtotaknthisoyportunﬂytofmllythwk

yonforyom-girt. Itmoxtmmlythooghtm ortho
and

I

have dooidod

to use it. in

w office.

Tait}:

group

the calendar

xiv-n m by tho Homo Neuropsyohiatrio Society, I
pom very fine desk pieces.

now have

Simonly you",
HISSCXJRI INSTITUTE OF PSYCHIATRY

Mu Fink,

Director

24an
em.

M.

D.

�</text>
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                    <text>'7’-

my

,V—.,.-

October 25' 1962
Dr.

Max

Pollack

Hilllido Hospital

Pa

0.

BOX

Glen Oaks,

38

New

York

Imeorrytohnve cmeedyouwonbarmatinuyphone can

yesterday, but I was calling on H! 2715 budm.8§ and believe it proper
to eel: the hospital to woept the ohm-gee. Hemmer, if this is a problem
to the program, I shell not ask this again.
we

I haw been dieeueeing

have acme

some

of the date with

James Vanderplns and

toaeonoineionwhiehlehouldlihetoehmwithm.
the
have

we been this to obtain a correlation
tin during poet year
matrix some: :11 the principal item in the study. This should be done
for the total population. Depending on whether we home a news of
tanning missing "rubles, end the reenlte of the ﬁrst analysis
probably should be reputed for the aciaophrenic sub-group; however,
in going over the original covariance analysis of the behavioral ratings
and the soul" derived for drug sensitivity, it is clear that neither
not of mama-u m the nut representative of our mph. Dr. Vamierplae
hwmeeomwed, and I believe that we should undertake, a factor analysis
of the'threo primipal rating melee (Lorr, Lorr Ward, and Johns Hopkins)

At no

forourtotelpopnntion. Input, thisvaeelao nakedbyone orthe
rotereea in the paper matted
by Hitler. hhile I was mutant about
doing this Int Mk: I have hed occasion to review the whole problem
and I believe that we should do it here.
I

hope you amour, and

girls to lay out
.

it uillbe

helpful

tho following information.

We

if you would

ask the

are pertaining-1y interested

in three than, mduonld “k thet the em sheets as used in setting
the covariance detu be used again. have the first two oolunne blank up
to
idontii'y the task; next, 160:3in patient umber, mutant type, and

mow-pout more. Thentm mamboleidoutestodigitmnbere
for 10 minus, continuously for
etch subject.

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>The

Johns Hepkina' seals
53.530“.

we

. each item score pro and post- by
.

scale a each item pm and post.

Len

Ward

Lox-r

interview scale.

the dictm
scores, by Don and veal! following
will be helpful if
should make as few me as possible,
were to punch the forty items for each examiner separately pro and

that

Here you have two

it

we

post for eech subject.
I think these three scales are more than enough to give us a picture
the
factorial dimensions for this population. I have the facilities
of
have
these scores punched here and shall send you both the cards and
to
our analyses

It

when

was nice

they are done.

chatting with you again.
Sincerely yours,
MISSOURI IKSTITUTE 0F PLYCIHATRY

Mu Fink, M.

”Mme.

-..,

wvm.

specific tasks are:

MFsaw

Director

13.

w.

WW

I.

,
r

.,,,.-,.

,,
”r

..
,7,

”t.

,...

WWW~.Ww—._-‘.vﬂ

cr

Please address correspondeme to: Shoo Arsenal St... St. Louis 39,

Mo.

�</text>
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                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                    <text>,
__..

NW...”

inn-«r,

culmwwn-mwm

w;

September 26, 1962

"u"—

,
WW

r
w...“

.m‘.W.,..:

Drs. Donald chin and Ms: Pollack
Hillside Hospital
P. O. Box 38

Glen Oaks,

New

Door Don

ﬂux:

&amp;

York

Thank you

for your recent note. I shall try to answor your

questions striatimt

E

l.

ghgggggtx A good idcs, and I have taken the liborty of
making sons sditorisl comments. Tho conclusion promises individual

profiles.

Row

do you plan

to

do

this?

Sinus I will_bo unshlc to participate-meaningfully in there
analyses, I would suggest you submit this from Hillside Hospital
only, under your Joint authorship. I would be pleased to road
the draft report as urittsn.
2. All covarianco analyses are in the master books or
the “duplicate” book. Tho covariance of the Rorschach (Problon 15)
was given to Ira and a copy of the write-out is in the big book.
Covariance of "new” ratings are in the large book and should have
your notes with them.

2-7...

"

One copy was given

as well.

to

It is

you

marked Problcm llull, dated April 6.
work and should be in your desk

for your

'
‘
‘

Tanisha."

separate cover I am sending you
(with orrors corrected after
sz
machine processing); the operative prooodurc for IBM program; tho
program dock for the 7072; tho uritcoout or the program; and tho
test problem writs-out using this program. This is a completed
program for book tests, and can be run on a 7072. It cannot be
run on a smaller machine since it needs a large momory. Program
zoos to stop of ”table look~up” which is very timo consuming and
bust dons by secretaries. Roforsnos is Siogol's Non—parametric
3. nggpﬂggggggiggg;

the original U-tost

and

Under

test sheets

Statistics.

(r
,ngw

.

in.‘

H,

“5.5.3;

w»:

(5) Cost: We will be billed $400 for this job. This will
b. added to tho Scptsmbsr ststomsnt from the washington University
Bulgatur“ﬁsitcr. Sines it is applicable to 2715 and 4798, I will
cuggost that uncuhalf tho cost be charged to each grant.

�.u.“

,_
...

‘1.

or».

3
“'

Dra. Donald Klein

&amp;

Max

Pollack

Septembor 26, 1962

~2~

(b) Runs: The Washington University center
program fbr us at the fpllowing charges:
For punching data €2.72/hr.
For 7072 tima $5/min.(user‘s

will run this

rat.)

subjects x 3 drugs) will take about $20 for
both
de and K-H takns about 1 minute on 7072.
sun of
punahing.
data, have the girls
If you wish any runs on the presently availablesheets
(covariance
will do nicely)
transcribe the raw data to shoots
on
and send than
to us barn.

to

punch 100 problems (50
Each

,

Good

lmk with thc

»

APA.

Sincerely yours,
MISSCXJRI

MaxFink,

eraw

INSTITUTE OF PSYCHIATRY

M.

D.

�Summary:

Self—descriptive questionnaires have been

advocated as a preliminary device in psychiatric case study.
In

this investigation various patient-rated instruments

were

analyzed, and the selfuratings were compared with measures

N

of ward and interview behavior and with psychiatric diagnosis.
symptom, mood,

Selfbratings in the areas of

attitude

and

social attitudes using the: 1) Frank

(John Hopkins) check

Attitude Scale
one hundred

and 4)

list;

_2)

Clyde

California

F

Mood

personal
Symptom

Scale; 3) Whitman

Scale were obtained in

forty-four voluntary psychiatric in—patients

referred for psychotropic medication.
In addition, each patient was rated by observers

l) Jenkins Psychotic Reaction Profile

using the
2) Clyde

Mood

Behavior);

Scale; 3) Hillside Hospital Somatic Treatment

Referral Scale
A

(Ward

and 4) the Interview

section of the Lorr

MSRPP.

factor analysis of the self-descriptive scores

resulted in the following factors:

1) Clear Thinking;

2) Somatic Complaints; 3) Dysphoric Complaint;
Mood, Dependent

Action; 5) Aggressive

Mood

A)

Friendly

and Action;

6) F Score, Friendly Action and 7) Angry-Dependent—Withdrawn

Feeling.
A

factor analysis of the description

by observer

scores resulted in the following factors: 1) Angry; 2) Withdrawn;
3) Tension-Apprehension; 4) Communicative Disorganisation;
5) Somatic and Neurotic Complaint; 6) Sleepy Depression;

7) Guilty Intropunitiveness and 8) Rate and Reactivity.

�E

.2Those

each

patient,

factor scores

were analyzod as

and led to groupings according

l) Self-descriptive profile;
The

profiles for
to:

2) Description by other

relationship between those groupings

psychiatric diagnosis will

be discussed.

and

profiles,

,

�NcnoPerametric Statistical Tests
Operating Procedure
Date should be punched in the following format:
1. The first card should be blank (or at
The

other

will

79 columns

particular problem.

be

printed as the

least numeric) in column 1.
first line heading for that

2. The second card is a control card punched in format (1!;
containing the following information:
minimum

2

e.
of 3.
&gt;

11 12

b.
for ebeolute scores.

the

number

e 1 or a 2.

of

columns

for this problem

1 means the signed scores

Il,

1013)

- maximum of 10,

will

be analyzed;

1013 - up to 10 numbers giving the number of elements in
of 150 for any one column.
cards follow, punched in format (SH
, 15F5. 0);
and
be
5
i.e., the first colunno may contain identification will ignored.
There should be a set of date cards for each column, one set right after the
other. However, each column must start on a new card. Alec, the number of
elemente for each column must correspond to the number punched in the control

c.

each column, maximum
3. The date

card.

The preceding gives the format for one problem. Any number of problems
may be run at one time, with no pause in between. The complete data sets should
follow one right after the other.
The date should be put on tape
They will be read from tape 3. Output
can go on any unit.

in card
will be

image form
on

tape 2.

(Fortran card—to~tape).
tape

The systems

,

ﬂ

tape mark in written on the output tape by the system at the
conclusion of a net of problems. If the Batch Compiler is on unit Q,
units 1 and 4 are ready, and alteration switch 1 is on, a tape merkjwi11 be
No

.

added.

Otherwise,

it

must be done manually.

.

��1

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                  </elementText>
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                    <text>x.)

mm
W
loom a,

Dr. Max Pollock
mum. Hospital
P. 0. Box 38
Gloh Coho. Now York

5400 koonol Stroot'
St. Louis 39. Mo.

1963

.

;

f

.

'
'

Door Max:
Thank you tar your tocont lotto? and I shall try to o-nowor

coach paragraph

”womanly.

Tho props-om {or o molouon mom: with mtootoq vortobtoo
woo mittoo for 50 muhloo out! it woo dﬂﬂoult to unto tho propor
commands for tho .9
which I had in hood. 31m Vanda-plan
wanton, on this prohiom for ohout a wool: on! nanny solved tho pregamming by on: moo on tho mmtor mung. varietal portions of tho mount.
Tho hurt stop to how in promos . All tho math!” hovo boon tndoxod
on»: and tho
oooroo obtotnod. Friday ottorooon o mohttoa
matrix for ohanqo moron
run but map to tho prom-om resulted to
o quboqomotrtx. Ida not think too hovotho who to clan this up this
woo): and :t to poootblo that 11th will got to it only out ﬂock. To tho
«igloo! 89 vortobioo for whom wo have dortvod Mount scam . too
Most throo social oortoh!» tor tho omolottoa mom: .. oqo. oduoouoh.
oud out. It woo to
thou mutate: out of tho soon! vortohlo
thot Ibooomo «mood ohont tho
of tho lost for: ttomo .
Elmo Ida hat hovo tho nominal patient Moto. it to not our for mo to
chock whothor tho loot helm roﬂooto
or prokuo trootmojnt
by 4: drug in o ported loss than throo wooko .

with!“

4mm:

Mo

W

‘

on

mom

mm
mom“

If tho progroot will run. I will ehtotn ohohqo oooro mutton
for tho 89 voriohloo om throo about!
ovanohlo to no

Woo

by
ot tho prooont moo. humid ooomo that tho clonal staff has otortod
dooodthp oh tho Bohovtorol Sooloo to that too ooh ohtotn oomo footer
ominous of thooo. With omo oddmonol lobar tho ohonqo wan motrtooo
should ho dotto by tho out! of tho month.

'

�Dr. Max Pollack

January 8, 1963

«zr-

Yaw amend question 1- an rusmsthmty for Hanna'81:. Loan.
do
I
not
mk.
no how I an sup-win this
that you have main-d
budqut and and: «totally and aspect
you to do what 1;; in tha but inure-ta of the original grant program.

m

m

Ikm

Ihavo rwclvad the OFF paper, and have rand it this
mad; I numb“ of not“ and will
Ihavc
this paw
mains}.

rm

but on thin wank.

Sine-rely warn,
MISSOURI INSTITUTE OF PSYCHIATRY

Max Fink. M. D.

Dinette:
MP :3!“

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                    <text>xxxxxxxxxxxxx
xxxxxxxxx

suoo Arsenal

St. Louis 39,

January 16, 1963

Dr.

Max

Street
Mo.

Pollack

Hillside Hospital

Po 0. Box 88
Glen Oaks. New York

Dear Man:

I have rand the paper in its entirety and have made a
of marginal notes. The draft copy is enclosed. Hy
overall impreasion is that it "trias too hard" to find a
"raison d'ctre". Perhaps itﬁshould be recast as a simpla
report for Sci nﬁe? Or one 0f tho psychological journals.

number

the Haydn refergnce (page 13). as I.
cannot recall reading it.
,:N
You may also wish to change the title to follow the
style of the SINT papers. making this one the third in the
Can you

give

me

'

series.

Secandly, I

am

enclosing the

first

runs of the Correla»

tions cf Change for your initial study. 'The indexing for
such a correlation matrix is still a mess and tweathirds of
the correlations for Treatment Type #1 ara included. The
and varies from 31 to “2 and each correlation is based on
tha number of subjecta for whom pre and post data wcra available for both tests. The guide as to the type of variable is
included and the numbers follow cur ori inal pre~poaition
correlation matrix. In the final corrugations, age, education,
and sex, will be included as variablua 90~92.
As soon as the behavioral data is transcribed, I can get
the staff hare to begin the punching of the cards.

�Dr.

Max

I

Pollack

am

~2~

January 16, 1963

sending these correlations because I have spent
I find it difficult to

two avonings going ovum them.

conceptualize a legitimate approach which would not capitalize
Perhaps you and Don and Ira could check thc range
of values and give some seridus thought to tn. methods of
analyzing this type of data.
Sincorely yours,
on chance.

MISSOURI INSTITUTE OF PSYCHIATRY

Max

Fink, M.D.

Director

Hrzjr

Enclosures

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                    <text>om‘auou

manna

our MINTAL

MISSOURI INSTITUTE OF PSYCHIATRY
51’.

Lows

STAT! HOSPITAL

,

I‘OO AR’INAL ITIIIT

,

8?. Lowe 39. Museum

March'l?,
. Mnx*?ol‘ack

'lls ide

hospital

ch 38
New

. C.

Glen Oaks,

It

has

a

tr

av. ,. .'
)a'.‘

-,I

«

a

‘.

A

York

tee:

sirc: t e"e has been any
Louis ard Hex ’ork a:d before

a few months

f i,”
: ”v.
o--.,:~
I ﬂ,.- 0| a: I...
‘~ ;“ Aw§’p‘
.
nu. ”A
at---~.
‘vabn
”'19. v:v~r.§. r") ‘1--:-f‘ ‘v‘.'f "1‘,
jnr'~‘v-‘:p~9 «‘89-3 a
a. raving
'u..wa.-..av
..
I H
t‘39 ”::nston
1r. OVe'all 71~ Kansas

‘'

1°63

..

cormuzication betweer Pt.
e.&lt;.

‘..,.

on
nu cm.g...”

1.5. “g...“

.

~

.

»

&lt;'

'

I

I.

.

V

0

‘

.

... v9 5.
hgtf
.Pst wear
d
t: .eet \
and {urticioate in n =eninar on F3112; 3:3;93.
for t2. 1520
that he had some orbarars wt
A

1‘

7

.

-

-

a

.

t.e:

T

a

indicated
concuter which
He

'

”351d permit the clasrificaticn oz‘ rat.ents. The_:rogrnms
reiuire, hnweﬁer, tnat the idea‘ized profiles he establisha: f;rs- ant that taco, by con: 3.riscn t: the idealized
prafi1.es, the cubiects can be classified into groups.
.zis operation wruld reiuire tnat ve .ive up the possibility
ion and decide on a few croupa which we
of an outside cri
usim;e
our data. Having made such a description.
can describe
we should be able to determine the distance that any subject
has from‘the idealized version.. In this way, perhaps, ve-can

then take

a

look at the

clinical chances seen in these Fronts.
.'.

tr.

~‘

I

Overall viii oe’a participant in the V.A. cooperative.
studies in roycniatry in Kansas City on March 26-27. I am
planning to be at that meeting. If it is roesible for you
to attend, he has indicated that he would be willin: to meet
wit: me and go over the Hillside data.

meeting: vii 1 take place at the Hotel President in
Kansas City. There i s a free period the evening of March 26th
and this would.be a r easohatle way-to spend that time.
The

1

iibert: of
t‘l. trip.

an taking the

.Lev hoping

sendinc a carhon of

that this description may

tion fOr. you to

make

be

this to

sufficient Justi'ica-

Sincerely yours,
MEX

MF:av

F1“.

Director
.

.

cc: Dc. Levis Robbin:

M. De
.

'

'

�</text>
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                    <text>..

DIVISION OF NINTAL

OIIIAII.

MISSOURI INSTITUTE ,OF PSYCHIATRY
51. Lows STATE HOSPIT'AL
5400 AIIINAL ITIIIT

m

"L. “am .4130
Am can. am

Br. Louw IO.’Muuoum

March 19. 1‘53

r.

Max

Follack

“f.lside Fuﬁbitul.7.

EC.

“:1.

'

.38

Glen Haks, Nnv Y3?!

beer

Max:

t has been

months

a few

sirce there

cvmmunicaticn'tetveﬁr 9:. Denis and

:Lrsinp

inks

“1".”

tr. =;'g".“~‘.

;

‘

befzre

and

the ‘rif‘l'=‘.ie f'f'ra‘.ior,. '

“7:.

m

been nrv

185

fart

New

:rt‘.;f;"_" .; I‘H'fr’;

1);;

'::h'5;n ::

=':"...‘.'i‘
'31:: 13‘1“.»‘3'.

Kie"‘54..

-

meet ‘:. ﬁve“1;i ‘2 ﬁ21:1,
-aniuar
rating : ave
. s .- He indicate?
c3
Idrtiziaat»
1620
?nr
he
the
had
concuter unich
written
some
prnvrams
that
wauld permit the cl ssi'ication of patients. 1%: :roarans
require, however, taut the idealized profiles @e-cstablisha: first and tnat then, by comzariacn to the iﬁealized
prnfiles, the cabjects :an be classified into groups.
This Operatisn wvuid require that V» give up the p¢5315111ty .
2' an nutsiée critefion and decide 3: a few hrouna which we
can desrribe using our data. Raving Tad: such a @escrivtion,
ve sheuld be able to detekmine the disﬁancc that Any suhﬁect
has from the idealized versicn.' In this way, perhaps, we can
Ln9n take a Lon! at (he clinical rhunges aceu in these :rouns.
“RSI week

5

the
in

Had

an-

=

.

'

2r. Overall will

participant lb the V.A. caoperative
Kansas
in
City on Miran 26-27. I am
studies in psychiatry
be
meetirz.
at
that
if it is ressible for you
plannfn; tr
to atYQﬂﬁg ﬁe has inﬁicated ttaz he would he willink to meet
v;tu me and to :ver the .i;;side data.
be a

‘

.'"

,‘-

,v

take place at the Hotel Presxdent 1n
Kansas City. There 13-: free period the evenirg of March 26th
and this.wculd be a reasonable way :0 spend that time.
The meepinis wt};

.

_

I am

taking the liberty of sending

Lev hoping that this description
t3c1 for'you mo make this trip.

may be

a carbon

of this tc

sufficient Justifica-

Sincerely yours,
Fiﬁ“.
Director.

.MQX

MF:av

'

'

~cc: Dr. Lewis Robbin:

'

M.

D.
-. “
'

‘

}

�</text>
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                    <text>“A-

”w.

April 2, 1953

“7,.”

.1)

Av”,

-,«m..v..v...

w:

w‘..'m-,.w...,w

1m

g

g

E

Dr.

Max

Pollack

Hillside Hospital
P.

O. Bax 38

Glen Ouks. New York

Dear Max:
Thank you for sending the ending abouts.
I have turned them over to the IBM unit and they
will begin punching the card: this week. We will
sand you a duplicata not.

Plcase thunk Gloria and Jean for the fine

job they have done.
E;

Sincersly yours,

E

MIX

KFtIH

Pink.

Director

My

Do

�</text>
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                    <text>wwww‘ wmwwawrmmv ‘MWWW
v

“Immm m.mwu~

May

Wm"-

v—w

20, 1983

Hillside Hospital

0. BOX 38
man Oaks, Kw York

Po

mm:

Immolosingthopnmfofamofﬂamiolea
GDP

III of the
pmooedinga. thing one past
experience as a basis. I an ordering 250 reprints with covers
and have mounted Elseviur to send you new-half of than
for your use.
for

Volume

I haw not mind the proof of No. II:
Perfumes Profiles”. In the amt that

”Psychological

Iwonldappmciateyouroomcting
Mmmttoyou,
than, and mooring sufficient reprints with com to Band

In

125

for

my

use.

The boxes

of cards have been shipped via Railway

Emma, to your attuntim, Hillside Hospital.

fiwmmdlmtlwymﬁwnfdy.

There are

Sinneruly yours.
ﬂax Fink.

Motor

ﬁrm

M. Dd

�</text>
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En. Max Pollack

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I m-sm‘y but the only wtpm: davioe that I

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Sinoemly yours,
Max

HPzaw

Pink,

Director

H. D.

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Dr.

Max

.

Pollack

Hillside Hospital

P. 0. Box 38
Glen Oaks. New York
'

mm:

same as

Moardlayuout forthe itemcazdsisthe

tn.
I

oovarﬁmm foxmt.

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Sincerely yours ,{
Max

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Director

M. D.

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                    <text>WP 19,

1963

Dr. lax Pollack
Hillside Hospital

75-59 263m Street
Glen Oaks, New York

Baum:

Mymvexymdszmessf’mm.
Itisgmm
it.

Idohopeﬁ'teCoauittee ampts

Inmldngupmtabla,

delta. you insert (3.5 - 5.0hmwr.1wwldsumtmtafter
cps) just as you indicated for
bats-d, which sham read (22 .. 33 ops). In the footnote for other
tests, it would be cleaner to insert after theta. alpha
bum-d.
tbs actual fmqwmiea (5.5 - 7.5), (8.0 - 12.0) and (13.5 - 20.0).
iPmnﬂntlﬁny, I recollect that the sixizubjects who am
mbusofthe
ageandmyhaw
had om 0th» ”social"
different fran the minder.
I also moollact that these six patients, if indeed
yam. may have
EEG

w

had

WMMW
Wﬂm

abnormal" ”mutant
"mwould
mm. Surely, if they are
slaw wava activity than the am—
thay not have

gnaw.

»

group?

m

EEG

.

I dohope tutbathyourpmmtationandnon'smrrtmll at
would

the divisional mating. I
port as mad.

be grateful for a copy of each ma-

Hith this laboratory mm running

tomvim Hillside data. I

I
My,this
material

have navigated some of

have more time
and

�19.
NOW
Page We

1963

Clyda‘s invitation in nidoncwmor
cf
36mm
m
Iwillbein
tomtwiﬂxhiminasendmr. Prior to that date,
is of any help. I

plan to

Dunn

If it
amuldbe gladto get togaﬂurwiﬁaymand goowrtiuwoﬁtof

New:

York (Novwber 28.29, Decenber t“-9)"

thus

past

few

mm.

m best regards.
Sincercly

yen-ma,

ﬁnk, H. D.
m
Director
Mf'mlg

�</text>
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                    <text>SEQ
“‘1.

.

'\

w
:‘x

E

V“.

n
XXLMMMXW
.

N

November 19, 1963

Dr.

Polladc

Max

Hillside Hospital
75-59 26313:! Stneet
Glen Oaks,

Haw

York

Durham
-

Itisgoodand
WywverymchforthBPAbsmt.
it.

IdohopotheCmndtme accepts

amt

In making up the table, however, I would
that after
dalta, you insert (3.5 - 5.0 cps) just as you indicated for
beta-2, which should read (22 - 33 m). In the footmta for ether
tests. it mid be clearer to imam: after theta, alpha “beta-4.
(5.5 " 765)) (800 "" 12.0) am (1305 “‘ 20:0).
actual
EEG.

fmmi”
I 133011th mat the sixiztbjem who am
iPmtgally.
thebassofthe sorgmmdgrmxpmmymmger amandmyhaw
m

had

am

different
rminder.
Maﬁa
six
if
ycunm,
mt than
Smly. if
mummm‘

other ”social"

I also manner

had "were abnormal"

patianm,
EEG

ﬁrm the

indeed

mm.

may have
they was

activitythanthem
www.muldﬁwymthawmslwwaw
disorganized

may?
hope that both your presentation and Don's want wall at

I do
medivisionalmting. Iwmddbegmtefulforaoopyofaachm—
portasmad.

Himmlabmtarynmmmingmmothly, Ihavamtime

to raving Hillside data. I have mviewed

.

m of this maria}, and

\\ﬂ-H

&amp; :‘xz
,v
‘4

.

�m.

m Pollack1963

19.
NOW
Page The

plan to take

m,

the past

mm.

of

Dean Clyde's

invitation in Ida-Decanter

date, Iwillbein
tomtwithhiminasemimr. Priortothat
is of any help. I
th9).
If
it
New York (NOW 28.29, War
goomz‘tmwot‘kof
armada gladto gat togeﬁxerwithyouand
few

My

best regards.
Sincerely yams,
Max

Fink,

Dim

MFzmlg

M.

D.

�</text>
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                    <text>February 15, 1966
Dr.

Max

Pollack

uillsidc Hospital

P. 0. Box 38
Glen Oaks. ﬂew York
Dent ﬂax:
haw. received the records and as soon as I have a chance.
Turon and I will go over than. I hepo we can confirm some

I

of tho ”analyzer” data.

«want: occurrod at the moaning of the Clinical Committee
wklch moy interest you. I was discussing tho general problem
of the EEG analysis with a number of tho staff, and our recon:
Two

discriminato function came up for discussion. I indicated
that the group of schizOphronic patients who stood out were
most likaly theta who were classified as childhood achizo~
phrenia. Knowing Dave Engclhatdt's interest in thi: question,
I suggested that he undertake such a study in his populations
in Brooklyn. Kc baoamo very much interaotod and asked me to
colloborate. This is most diffioulc, but I suggested that you
‘

may

do a

Itill

bu

internatnd in

batter job.

Are you

ono who could
it. ano I know ofinnotracking
down
still intorestcd
would
call
that

you
suggest
chanson in kids? If no, I
him in Brooklyn, and I know that you will find him halpful.

the

EEG

Clinical Couaitcco also ditcussod the problem of ovaluation
of arugu for the creatmant of doprctnion. In addition to the
collaborative atudius of schizoohronia,_they will probably
launch one on dopresuion this fall. when the model was presented. to compare iniprnmino outlast placebo, I took the position
that u: could laarn ovan more if there were a sufficicnt number
of suhjaotn treated with iuiptaninn, chlorpcomaainc, and placebo.

The

They second to acocpc this rucouncodntion with the execution of
the addition of Kcmadrin to tho ohlorprooaxiooa They will
probably make a :tudy similar to our own.

failed to proton:
clearly tho data on tho thorapnutic efficacy of chlorproaazlno
in doproalion. Baforo John Kramer left, I hid naked lin to
write thin up. and my ruoords haw: only an ineoaplota draft of
that rcport.

One

truth enurgcd.

and

that

was

that

we had

�Dr. Ha: Pollack
2-14-65
Pug; Two

I ballcvc it unuld be uurthwhllc to sumaarlso ch. obcorvatlonl
in an. daptatnive group along. comparing thc cllntcal results
with ch: thtca compounds. It would bu not: helpful 1! this
war: eoapletcd bsfora the beginning of May, :0 that caplel
¢oald be made available ta aha Clinical Comnltaea a: a ball:
for that: collaborative candy.
a study, it rapraaants a unique apportunity for us to hava a taut of some cf out hypothoucs proscntud
in 1959, which can only be adequately tested with a large sampla.

If thay undortaka inch

schodule is very tight for the re:c of this month. I
balleva l could work anxiously on this problem in the latter par:
of Mitch, Does 1: interest you and Don?
Hy own

still
it

I would
like to see I copy of your schizophrenia report,
and
theta is an extra ans available, I would suggest that
to Dave Engalhardt.
you send

it

Sincerely yours.‘
Max

MF/Jb

ﬁnk.

MOD.

�</text>
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                    <text>February IA, 1966
Dr. ﬂax Pollack

Billsido aospitsl

P. 0. Box 38
Glen Oaks, New York
Dost Max:
1 hava tsosivcd tho racords and as ooon as I have a chance.
Turan and I will go over thsn. I hope no can oonfirm soon

of the ”snalyasr” data.

avsnts occurred at the mooting of the Clinical Committee
intstast you. I ass discussing tho general problem
of tho EEG anslytis with a numbsr of the staff, and our recent
disorininsts function name up for discussion. I indicated
that tha group of schizophranic patients who stood out were
lost liksly those who were classified as childhood othizophrsnia. Knowing Dave Engslhstdt's interest in this question.
I suggestod that ho ondottaks such a study in his populations
in Brooklyn. Ho batons very much interested and asked on to
collaborate. This is most difficult, but I suggested that you
may still bs interostsd in it, and I know of no one who could
do a butts: job. Are you still interestad in tracking down
tbs EEG ohsnsss in kids? If so, I would suggest that you csll
him in Brooklyn, and I know that you will find him halpful.

Two

which may

Clinical Committee also discussed the problem of svaloation
of drugs for tbs treatoont of doprassion. In sodition to the
eollaborativs stadias of schiaophtsnio, they will probably
launch ans on depression this fall. When the modal was ptosantso, to compare ilipramins against placsho, I took tho position
that us could lostn ovon more if thsto ware a sufficisnt author
of aobjoots trastsd with iaiptsnins. chlor’oomasins, and plscsbo.
rosy sscnsd to snoopt this rooounsndation with the oxosption of
tho sodition of Konsdrin to tha chlorptoassins. They will

Tbs

probably make a study

sinilat to our

own.

truth alstgsd, and that was that as had foilsd to prosont
clsarly ths data on tho thatspsutic efficacy of chlorpronssino
in daprsssion. Baforo John Kramer loft. I had asked him to
writs this up, and ny racords hsva only on ineoupleta draft of
Ono

that roport.

�Dr. Mix Pallack
2o14~64

Past

Two

it would be worthwhile to tumunIIIa the ebuorvatianl
in the dcprocnivo group along, comparing ch: cltnleal results
with the thtgo compounds. I: would bu non: helpful if thin
var. aonplctcd hoist: ch. bogtnnlng of May, no thtt caplet
could be and. availablo to tha Clinical educates. as a hunt:
to: that: collnborntlve study.
I helluva

If

ch03 undortnkn such a :tudy, 1t reptcuantn a unique Opyoru
tunity for us to haw. n can: of son. of an: hypotheses presencod
in 1959, uhieh «an only bu adequately taste&amp; with a large sample.

own schoéule is very tight for the run: of thin month. I
helluva I could work serlouuly on this problem in the latter part
of March. Doe. 1t tutorctt you and Don?

My

I would still like to ace 3 copy cf your schizOphtenia report,
and if there is an extra one available. I would suggnst that
to Dave Engalhardt.
you send

it

Sincerely yours,
Max

2419/31;

Fink,

M.D.

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                    <text>H

f"

ijﬂf”;
if
‘

M

A

(

.

x

waif f!

3“

,
.
”,1.”

,7

7

5.1,»

.

'

H}

,,

.
o")

f/

p, .4... 4m.“ Aw n.

April 9, 1964

Dr.

Max

Pollack

Hillaide hospital

38
Glen Cake, New York

Pa O. Box

Dear Mex:

I have read your pope: with interest, end have made-a faw comments
in the margins at well at some euggeetiona about the text. My big—
geat queation is why this report does not reflect your thinking in
the use of imipramino as a cleanifioatory deviooa As I recollect,
about two years ego you wrote a preliminary roport comparing adult
schizophrenics with behavior disordeta. In that atody. the analysis

of the effects of imiptomine were not included because we had not
yet analysed the date. It seems to me that this report is en opportunity to emphasize again either in the discussion or the text, the
fact that inipramlne seems to be a good device to separate the
achizophrenic patients, especially the childhood group, from other
achiaophtenic papuletions.

three comments in the margins are as follows: On page 5, I wan
concerned as to how these specific behavioral acalee were selected.
Theta were many other: that were available and we are always subject
to the oritioiam of aalecting acelea for tasks that reflect our bias.
If these were aelected heeauae they reflected specific aspects of
behavior, then thia might be stated. I also wondered if theee were
the-original acorea or one of the derived acorns ea reported by Don
in Payohopharuaoologia.

The

Content 2. on page a. 1a to tuggelt that if you apeak of the records
ea being ”abnormal”, than the olaaaifioetion of the EEG should be_

stated in the

method since

been described.

I

do not know any

other place

where

it

he.

in related to your auggeation that the effects with imipraLSD. with regard to the electroencephalogreohic
LSD
does motmyﬁoduee a definite inoreeae in fast activity.
effects,
The results that you describe are cloeeat to thoae teen with antioholinergio compounds. such as Bitten. Indeed, the combination of
increaaed slow wave activity with a great deal of feat activity ia a
ooubination that we have aaen regulatly in our patients who are
receiving Dittan and-other antioholinetgio drugs. I do not know how
Comment 3

mine are

aiuilat to

(

I

1‘

gtot-4'4

‘

f...

#3

4/
I
19.1)“! ”sq/$1}?
fr"
gMZTA/{tf ‘WI‘

/

�Max Pollack
é-Q—ék
Page Two

Dr.

you can

groups.

Would

numbers of the

to the referoooe of
is in error.

Abrunnoo, but tho

EEG

changes of great

intorost.

and

patients?

what did happen to the report on adult achizo~
phranlos with behavior disorders?

sincerely yours,
Fink.
Director

Hox

-v

.——,

HF/jb
33$ 0

it

tho patient: included in the thxoo
be
solo
to send an the names or the
you: sooratary
know

Paronthetioally,

“m—M—

mmmmv:vw.m

EEG

I find your anolyslo of the
helpful to me if I

would be

p,

WWW—ya

and

this association.

w..--..

"Vuan‘Hr-‘y-

comment

LSD

Finally. I would be intotoltod in the relotioaahip botvoen the
changes in blood prosluto to tho root of tho spectrum. I do not
know how to relate these changes to oithor tho psychological task:
or the EEG, and pothopo you can include soon gonornlisationo about

.4.

”7”,,

roloto this

ouggostlon about

M.D.

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                    <text>April 9, 1964

Dr.

Mex

Pollack

Hillside Respitsl
Po 0. no: 38

Glen Oaks, New York

Dear Mex:

I hawe read your paper with interest, and have made a few consents
in the mergins as well as some suggestions about the text. My biga
asst question is why this report does not reflect your thinking in
the use of iniptsmine as s cleaniticstory device. As I recollect.
about two years ago you wrote a preliminary report comparing edult
schizophrenics with behavior disorders. In that study, the snalysis
of the effects of ieipramiue were not included because we had not
yet analysed the data. It seems to me that this report is an opportunity to emphasize again either in the discussion or the text, the
feet that inipremine seems to he s good device to separate the
schizophrenic patients, especially the childhood group, from other
schizophrenic populations.

comments in the margins are as follows: On page 4. I wss
concerned so to how these specific behavioral scales were selected.
There were many others that were available and we are always subject

The

three

to the criticism of selecting scales for tasks that reflect our hiss.
these were selected because they reflected specific aspects of
behaviot, then this night he stated. I also wondered if these were
the original scores or one of the derived scores as reported by Don
in Psychophsrsacologis.

It

Consent 2. on page 4, is to suggest that if you speak of the records
as being "shoot-a1“. then the classification of the EEG should be
stated in the method since I do not know any other place where it has
been described.

that the effects with inipraeffects, LSD doseoﬂoytpdoduce a definite lacrosse in test activity.
The results that you describe are closest to those seen with anticholinsrgio cospoueds. such as Bitten. Indseﬁ. the combination of
increased slow wave ectivity with e great desl of fest activity is e
coshination that we hsve seen regularly in our patients who sts
receiving Ditrao and other anticholinergic drugs. I do not know how
Connect

3

is related to

nine ere similar to

LSD.

your suggestion

With regard to the electroencephalographic

�Dr. Ha: Pollack
£~9¢6b

fag.

Two

you can

relate this

nuggcotion about

comment

LSD

and 330

to the retercncc of Ahrlnnon. but ch.

is in error.

Pinnlly. I would ho interaoccd in uh. relationship bctvaca :hc
changas in blood prcsluro to thc ran: of tha spactrua. I in not
know how to relate theta changes to 01th:! the psychological tanks
or the EEG. and perhaps you can include cons ganaraliaationa about
this association.
I find your snalysia of the EEG changes of great interest, and it
would be helpful to an if I knew the patiantl includcd in tha thrcu
gronpa. Would your secretary be able to send me tbs names at tho
nunbcrs of the patients?
raranzhatically,

what did happen to the

phtnnicn with behavior disorders?

report

on adult ochizo~

Sincerely yours,
Pink.
Director

“‘3‘

MF/jb
ﬁne a

ELI).

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                    <text>April 21. 1965
Dr. Hex Pollack

Hillside Hospitel

P. O. Box 38
Glen Oaks, New York
Deer Mex:
comments are releted mainly to clarity of English. Secondly,
cube
it seems you ere missing your main point - that of e unique test".
by
disorganisetiou
this
'ieipreeine
in
schisophreeie
group

My

is similar after ieiprenine is interesting. but
the feet that they had behevior disorder, early onset. melee, 1??
the inputtent stete-ent. and should be cast in the con- this isDon's
three reports (including anxiety group).
text of

That the group

for EEG - the etete-ent from the enclosed ebetrect is correct
"for the stone“ - but you ere specifying the date for individual
subgroups end here, inipremine effects may be different. My
letter of Fridey should contribute to this. If you wish to pull
out these six pre- end on~drug records, I csn either see then in
New York this weekend end quantity. or if you send thee to St.
Louis, I can get the dete to yen in 68 hours. I suspect these
recatde will show different changes from the other iniprsuine
subjects.

As

Sinaerely years,
He: Fink, H. D.

Director
MF/jb

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                    <text>April 17,

1964

Dr. Max Pollack

Killsids Hospitsl

Po 0s 30! 38
Glen Oaks, New York

Dost Msx:

is the history and present ststus of my attsmpts to discriminate bstwnsn schizophrenics sud depressivss, using the EEG frequsncy

Tbs folluwing

snslyssr dsts.

Estly lsst winter. John Stern ptssentad a paper in St. Louis showing the
diffsrsucs batwssn achisophrenic patients and s control group, in a cross
torrslstion analysis of EEG signals. His study was wall dons sad it canfirnsd the findings of Kennttd. Partly as s lstk, we obtainsd s distrimin~
sts function snslysis for tbs lib pstisnts, using tho EEG bands of delta,
theta, stc. The F ratio was 3.08. with a significant P at the .01 lowsl.
Hhsn looking at the discriminate function cosfficients, the dsts bscsns
quite pussling. Tbs msjor tantribution was wads by delta activity sud
bets two. Howsvst, instesd of having an increased snount of bsts and
lsss dslts in the sehisOphranits st every ans sxpacted. our dsts shownd
that tbs schiIOphtcnit group had more delta sud lsss bets tﬁt thsu the
deprsssives.

that point. I called and asked that you send us the records of the
pstisnts who wsrs st tbs two entrants of the distribution.

At

42

Reviewing ths diagnoses, it beeswc obvious first that of the first 25
patients at the schisophtsuic and of the diserininsts functien analysis.
9 had been lsbslsd childhood schizophrenia, and 8 undifferentistsd schizophrsnis in our early elasaificstious. The asst age for ths 20 schizophrsnic pstients was 22.9. and the meta ass for the E0 dsptsssivss st the
other and of the snslysis wss 43.5 years. Thus. tbs diffsrentistion was
not bstwtsu sthitophrsuis sud its dtpretsion, but childhood schiIOphrsnis
sad deprsstivs disordsrs.

Nsvsrthsloss, this was not s sufficient explanation so I asked Dr. Itil to
rswisw the_rstords with as. we snalytad such record scaording to the form
ontlotad with this lsttst. The records were placed in alphabeticsl order by
my sscretaty, and ws disrsgsrdsd the nets sud sgs of ths subjact. The records
wars tsviswsd. sspstislly the tasting psriad, the psgss analysed by the
frsqusncy analyssr, syn—opening sud sys~closurs. and hypervsntilstion. When
this wss done. the dsts wss summaritsd according to tha rstssrch diagnosis,
thst is, dsptsnsivs disorder, childhood schisophtonis, sud schizophrenia.

�Dr. Ha: Pollack
4-17—6‘

Page Two

Thsre were 12 doprcsslvos. 9 ohlldhood schisophrenlcs, and 21 achlaophranlca
among the records which you sent‘ne.
Following this analysis, chloh I will summarize lo a moment, wo further sub—
divided tho achiaoyhraolc patients into those who wore 25 years and younger,
and than: 26 and oldar. Thus, on havo.£oor groups.
Beta dominant records more soon in the dsprasslve patients and the oldar

aohlaophrenlco only.

whlla there were no differences in alpha dominance in the records. there was
a pradonlnsnt number of theta dominant rocords in tho childhood oohiaophtanio

group, and the gunman: schizophrenics.

la the tamalnlng'chatscterlstlcs, the four groups could not be distinguishad.
In reviewing the general rsoarﬁs, Dr. Itll noted that we had much morn alpha
and grastet amplitudas, greats: degrees of synchronisation. than he
was aocustnmsd to seeing in the schizoohranlc gatients in Erlaqgen and that
we are accustomed to oozing to our patients in St. Loulxl no asked if I had
any psychopathologloal~aymptom data for these patlaots. and slots John had
taut ms the $228 profiles. I called those as a rapid approximation of the
predominant psychopathologlc state of our subjects. The sheet is snolosad,
and shes: little differenco in agitation, apathy. delusions, and oven daprssn
alon among the four groups. Indeed. tho only distinctlvn dlffarsnsa appaara
to ha in hallucinations. and those are only occasional to the sohlsophranlc

activity

patients.

His response, and my own from having worked here to: the past two goats. in
to say that tho alllalda papulatlon is an extraordinarily unique one. As no
foané when aux Hamilton roviewod our patients. the sub-divisions into depras~
alva dlsordsr. sohlaophrenla. st¢., are guegsss with regard to the oventual

cutout. a

I

I ballavo this data to be quite important because it shows that can can
daaoaIttats tho diffsranccs bstween the sohlaophranlos and tho dapraaaed
patlants using frequency analyser EEG data. However. the diffsteooos are not
in tho usual dlraotlon and ara relatad to the fact that you hava collactsd a
unions group of brain damaged or otherwise EEG unique patients in this spacial
sample. Sotaly, tho futthat analysis of a largo: group of adolescents, and
tho young disturbad patients. using EEG asthoda 1s raquirad. It was with this
data haally to also. that l ancouragcd Dave Eogslhatdt to contaot you and aug-

gastad that he undartake such a study. Since then, I havo had the opportunity
to most with tho Chlldhood novalooment Rassatch Cantor group under Janos
Anthony. and have encouraged thou to allow an and my aasoclataa to undsrtake
such a study in that: population. Va have our own youth cantor with 50
patlonta, and a study has bean launched in that group as wall.
A

conflrmatlonnof these observations regarding the diagnosis of tho patlaots

�Dr. "‘3 P1311161!
‘-17~64
Pug: Turn:

come from your fellas up data. If the informa‘2
avntltblo for these
tion
paticats. it would he must helpful to know
havu
bcen rohonpienliued; their lator diagnoais. uspscinlly
which, if any.
1f 1: was and: by you: and thair predominant paychapathologieal symptoms
lone yuars after out obsorvation. If tbs: information is avnilable fat
than: pae1¢nca, it would ho helpful :0 clar1£y the pro-ant poultion at aha
ﬁnd

their clinical stat. can
13

Itudy.

not sure what I can do with the immadiata data of thts discriminate
function. I haw: an opportunity 1n-Loa Angola. to diucuua John Stern's
:cpart.n1nd may take occasion than to make some commnnta. Kauuvar. I éo not
know haw ova can pub11sh th1s kind of material ainca 1t nay be a ruflcction
at the uniqua papulatlon chattcteristien of Hillside.

I

am

Thank yvu very much for your halp, and I would be
you can mtka on chain remarks. no you want me to

grttciul for

any «caucus:

return the record: promptly.
am
hold
with to look a: than
than-far sang longar yeriod in case
or may I
Any
other nuggaatiout?
again?
sending Dan the max! version at the depression paper, and
of
the way, I should ltkc to writ: a more formal nunmaty of
is out

Sepsrately, I

whan zhnt

thc

EEG

am

matartal.

Sinaernly yours.
?1nk.‘¥,
Director
Max

2427/5»

Inc.

D.

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                    <text>April 21,

Dr.

Max

1964

Pollsck

hillside hospital
P. O. Box 38

Glsn.0sks, Nsv Task

Dssr Max:
comments are tslstsd mainly to clarity of English. Sscondly,
of s untqus substs missing your main point - that
it sssns you
test".
disorganization
group in schizophrenia by this "laiprsmlns
but
1s
lntsrsstlng,
That the group ls stalls: after 1miprsn1ns
l7?
the fsct thst they had bshsvlar disorder, ssrly onsst, 1nmules,
the
conhs
should
and
asst
- this is ths importsnt ststsmsnt.
My

text of Don's thrss tsports (including snxisty group).
As fat EEG - ths ststsnsnt from the snclossd abstrstt is correct
”for the group” but you srs specifying ths dsts for individual
subgroups and hers. inlprsmins effects msy ha diffsrsnt. Hy
cantrlhuts to this. If you vish tn pull
lsttst of Friday should
sss thsu in
out thsss s1: pts~ and on—drug tseords. I can slthsr
sand
than
to 8:.
new York this wsskend sné quantify. or if you
these
48
I
hours.
suspsct
in
Louis, I csn get ths dsts to you
from
inlprsmlns
othsr
ths
records vlll show diffsrsnt changes
subjects.
—

Sistersly yours.
”Ix Fink,
Dlrsctor

um»

H. D.

�</text>
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                    <text>may“

f-vw-w“*~

4:.

W:

.,.—,,.

.w-z—u-v—

w. mew.” ‘vrv-w“v'.ww

-—-

"

w 7w.

“" ""

w

-—- x ‘
*m‘Cxu

“Wm “
.

,

W

-

MW

October 29,

M Pollack
Hillside
m.

.7

1961*

DA- V ,ﬁ..&lt;,.z.w.,..,;

Hospital

Glen Oaks , Long Island

New

York

Dear Max:

‘4’

beau"

InAprilIsentywasmwyoftheEEG

frequency analyses of the schizophrenic and depressive
nub-groups. This problem interests me very much and
Dr. 11:11 and I diamond it again this week. He re-

mindedmmetwemellydomthevemadequate

psydnpetmlogicel description of each of our patients.
the extent that it may be available, I would be grateful if you could make available the following information
regarding the forty patients in this sub-study.

To

Have any been m~hospitalized?

md for any other that you

may have

Both

for these

seen, what is your

mmtdiagnoeis (ifnotmadebyyouornon, Iwouldlike
tomwhomade it)? Is thereany change intheippmm—
inent payohopattnlogical picture to

danger in

classification?

make you

oomider a

Please tell Don that the galley proofs on the
depression pepem have calm in and I have made all cor»reotions indicated in his letter of September 23rd, empt
adding the p values, Table I. Since the samples are small,
I would rather the narrative support the visual. You both
sham} know that Dr. Bradley promised all the C. I. N. P.
members «:21 September let that the 1962 volune would be out

Wt

byOotoberlst. I haven't seen ityetnorhave I seen an:
of it, but I have faith that it will see the
limit of day soon.
Sincerely yours,
Max

mf/ls

Fink,

Director

M.D.

unw-

w.

£19;-'ml r'dvvwlh‘uw-Y'vrnrqu

�</text>
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                    <text>Dumber 1a,

Dr.

Max

1981;

Polladc

musida Hospital

P. 0. Ba 38
Glen Oaks, New York

Baum:

ofthe Society of Biological Psydxiatry.
thas
DmxsmaIdthtsdﬂwwclmedabsmtasamultofmmmmtﬁm
At tho program

ms. Became of the

meeting

tin limitation, I accepted the raspmsihility

forhaving it

mtypedmdammdingﬂrisoopymyoumdmtonr.mmformappml.
Hymwidrtothﬂusabsuactwithhsr,plomwimtoDnmmaherger

accepthrgﬁnabsﬁact.md1mﬂdappmaiatsaoubmtomaoﬂmxomsupport

thismport Ihavaalraadymhudttsdittotlaspmmmdttommdﬂmafom
wiumtvotamitwulf,mabstmtmgudingﬂmdiscﬁminatemmimmlysis
oftheadaimpmmiomddsprassivestbjm.

Fwthisraason,1wasamdmm

lavamminfomtionaboutmfatsofmmpatimts.

Inmimdymmauccinctmplytowlastmtevﬁmlmﬂamdfrmmw
Yorkmdmgrattmtldidnotseema‘tmyofﬂrsmtinga. InatIr‘vin
Wattmmmandhsamddmrful,optimiatic,mdpleasadwith
mthmg (”1113 the outmohas jmtaﬁallmdaemary")

mmisaoopyofmaabstmctmdmlhavesubmittedtoﬂnaio-

logicalPsydriatrmeimuﬂdonotmmmitsfatewiuhe. I
mmmnﬁngmtmmmomaidarwmpﬂngboﬁrmmportmdm.
W'sasmntrihatimtotm annual problemofmmddiagmis.
Sinoamly yours,
ﬂax Fink,

.

,

mum

MJ)’.

�</text>
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-w

7w

‘_

WW...

.wwv

Jun. 7,

1965

”mm—mu"uwuvmv—W.W;—WWW—.WW"hm—"m..._..—&lt;..._-....,_._~,

Dr. Max Pound:
Hillsida Hospital

P. 0. Ban: 38
Glen om, New York
Dear Haas

wm

Myouwrynmhformmprdnts
fmlmtyem
I a enclosing a pmprint of
lastmﬁa foryour
aupmmtaﬂmmmIgminﬂwYmk
‘tomt.
8101031311 Psychiatry Matting.

'uuauwmw'ﬁm

Sincerely

ym ,

\q"""mwe:;tym

Max

Pink.

H. D.

Professor of Psydﬁatzy

u-u-mera-ry

.

«101mm

�</text>
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                    <text>February 19, 1971
Dra. Rhea Dornbush and
New
New

Stanley Feldsteiu

York Medical College
York, New York

Dear Rhea and

Stanley,
seminars in Psychiatry, a

new

quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. 1 am pleased you have accepted the invitation
to contribute the report on "Memory and ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

To meet the publishers deadline, can
you make a
by the end of June?

draft available

It is a policy of the seminars to re—issue reports of general
interest in hard cover. If we are successful (and
I
the
volume to have widespread interest), the volume shouldanticipate
then be
cited both as a periodical and as a book. assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Max

Pink, 5.9.

Professor of Psychiatry

Mszt

�</text>
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                  <elementText elementTextId="106922">
                    <text>19

“3::

L.

March 1974

m, Ptho

Departunnt of Psychiatry
University of Chicago Medical School
950 East 59th strect
Chicnso, Illinois 60637
boar Bob:

I am citing the libarty of sending you a copy of the papar
I just praaaucod a: the AEPA. When I was faced with the prdblnm
of dsvnloptng a prcsentation on the ginoral subject of "Evalustion
of voychochcttpios," I alocted to resurrect the work which no did
not: than a decade ago.
You may also be plugged to know that tha volunn. Pszchobiologz
of Canvulatvn Thargay. which pruacnts the proceedings of an RINK»
:ygportad confgrcnca in 1972, has just been publishcd, You may be
pleased to see your work extensively quotad.
My

bunt regards,
Sinccrcly yours.
24“ Fink; MID.
Proﬂessor of ?¢ych1atry

Mflcia

Encl.

x:-

:rvyympwmn-

.

w,-

.

�</text>
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                    <text>Jana

4g

1964

”to m‘rd H. P011”
Chief, Neurology'Branch
U. 8. Army Edgevood Arsenal

Chomloal Rotoarch and Development Laboratories
Edgewood Axuennl, Maryland 21010
Door

It.

Pulley:

It would be a pleasure
ﬂock of June 22.

to

have you

visit with

on

during the

an and notify us of your aim of arrival.
V111 make our facilities available to you.
If

you

will

Sincerely yours,
Pink, x.
Director

max

MF/jb

1);

we.

�</text>
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                    <text>July 15.

Professor Necnettin Polvsn
Department of Neuropsychiatry
University of Istanbul

Istanbul,

I was very pleased to receive your kind invitation to visit
during my forthcoming trip to Europe. Dr. Itil has spoken
most highly of your'programs. and has described the beauties
'and pleasures of Istanbul so well, that I an delighted to
accept your invitation.

View”

.u-‘s'rv-rv

,7

I have had some difficulty in making arrangements. but it
is now established that I will be arriving in Istanbul on
Thursday, August l3.‘ I‘an scheduled to leave Istanbul at
noon on Sunday. August 16. I will be pleased to visit with

a“...

1....

4—1,...”

.

\‘z

Wax-r»

3'19Wu-1—m

W

1-3.:

Turkey

Dear Professor Polvan:

0...,”-

—.—.

1966

_

you on Friday.

There are two subjects of great interest to me. and I would.
be pleased to discuss either one with you. ‘For many years, I
have been interested in the node of action of convulsive
In this, I have
therapy in the treatment of the mentally
come to the view that convulsive therapy is a form of controlled trauma to the nervous system. and that the beneficial
effects are the result of the brain changes induced. These
changes are best reflected by chemical changes in spinal fluid.

ill.

slactrographic, linguistic
havioral patterns.

and psychological

teats._snd

be—

other principal interest is in the extension of this theory
to the mode of action of psychotropic drugs. For the past few
years I have devoted cost of my research energies to the anal.ysis and evaluation of the patterns of brain wave changes with
psychotropic drugs. I would be pleased to describe the various
patterns found as well as the many new methods. including computer analysis for EEG analysis. It was through these studies
My

that I came to know Dr. Itil.
excellent collaboration.

and

I

am

most

grateful for his

�Professor
7~l$~64
Page TWO

N. Polvan

wife and son will be with me on this trip, and for this
reason I hnvo rnquastcd accommodations at the Istanbul—Hilton.

My

I look forward to seeing

you

act:

month.

Sincerely yours,
Max

Fink,

Director

M. D.

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                    <text>—~.

.-

«v-v—n

rm—l -—

’r‘v'av' «cw.— ..v.

.

:.-v.......».. "mm...
-

.

m.-

.

_. .

aw,”

“farm—nun.“

.

--

,

m...

..~

we,

~

ma w

»

..

. --

_.

»

.«r

.—

r

.

MW.

..

w".

,_

..

urn

_

-

~..-A

.7

,~

“7....

October 13, 1969

Prof. Dr.

N.

Polvsn, President

Turkish College of Neuropsychophsrmscology

Tslinhsne

Abdulhakhimid Cad. 76/4

Taksiu - Istanbul
Turkey

Dear Professor Polvan:

to have been nominated a corresponding
of the Thrkish College of Neuropsyohopharmscology and so pleased to accept membership. My associations with
Turkish psychiatrists have been among the most rewarding of
my professionsl (and personal) life - and I extend to the
TCNP, my best wishes for success in its meetings and publications.
I so honored

member

in

also look forward to joining
in Istanbul.

I

1970
My

you in the

first

thanks, and best personal regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. T.

Itil,

Vice President

meetings

L

w. —.-..

,_

7““.

.V

i...

.

_

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                    <text>October 13, 196'4

Dr. N. Polvan

Department of Neumpsychia‘try

University of Istanbul

May

Istanbul,

Dear Dr. Polvan:

return to the United States ,‘ I have recpleasure our visit to Istanbul. The little
manta that Tumn brought to you is but a token of our many
pleasant hour's. Enclosed are sum pictures of your wife and
yourself which I took during our visit. Please accept these
from my wife, my son, and myself.
Since

ollected with

My

my

much

best regards to your wife and your nephew.
Sincerely yours ,

Fm,
M
Director
Inf/ls

e nolosures

MOD.

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                    <text>November 5,

,

Dr. Necrxettin

P913931

-

19614,

A

Iamartin Cad. Burun Ap. 17/1

Talimhme

Istanbul, 'mrkey
Dear Dr. Polvan:

Since 'hman's return

we

have had the occasion

to

reflect on my experiences in Istanbul and to discuss the
wonderful possibility for psyduophamacologioal research
at the State Hospital in Istanbul. Since the populations
at the State Hospital may represent a number of patients
who are mtmated by psychotropic drugs, I believe it
represents the opportunity for studies no longer; possible
in the United States. When we spoke to Dr. Bayulkem, I
was impressed that he was anxious to mdertake studies
at his hospital, especially studies that would give him

'

an opportunity to have a large supply of new or established
psychon‘opic drugs-

Also, I was very such impressed with the hospital's
extensive work-therapy pmgrom. With these facts in mind,
I discussed the possibility of a collaborative study pro—
gram with some of the representatives of the Clinical
Canﬁttee of the National Institutes of Health. My were
interested, emd it is nm up to us to prepare a formal
protocol of a study program. To undertake this, I would
like to recommend a few models that we have discussed here
and obtain your opinion as to whether any are feasible.
If they are, there are ammlber'of facts which we would
like to have so that we can make the necessary applications.
take two groups of schizophrenics - those
never treated with psyclwtmpic drugs and those previously
treated, and determine the efficacy of a phenothiazine in
both groups.
A) We may

~

If there are a, huge nusber of patients who have
been untreated with psychotropic drugs, we would like to
have the patients first stratified into two groups according
B)

to diagrosis: schizophrenia

and other diseases. In the
sdxiaophrenic group. we would like to suggest a test of
three forms of therapy: psychotropic dmg therapy alone,

�November 5,

,

Dr. Necrxettin

P913931

-

19614,

A

Iamartin Cad. Burun Ap. 17/1

Talimhme

Istanbul, 'mrkey
Dear Dr. Polvan:

Since 'hman's return

we

have had the occasion

to

reflect on my experiences in Istanbul and to discuss the
wonderful possibility for psyduophamacologioal research
at the State Hospital in Istanbul. Since the populations
at the State Hospital may represent a number of patients
who are mtmated by psychotropic drugs, I believe it
represents the opportunity for studies no longer; possible
in the United States. When we spoke to Dr. Bayulkem, I
was impressed that he was anxious to mdertake studies
at his hospital, especially studies that would give him

'

an opportunity to have a large supply of new or established
psychon‘opic drugs-

Also, I was very such impressed with the hospital's
extensive work-therapy pmgrom. With these facts in mind,
I discussed the possibility of a collaborative study pro—
gram with some of the representatives of the Clinical
Canﬁttee of the National Institutes of Health. My were
interested, emd it is nm up to us to prepare a formal
protocol of a study program. To undertake this, I would
like to recommend a few models that we have discussed here
and obtain your opinion as to whether any are feasible.
If they are, there are ammlber'of facts which we would
like to have so that we can make the necessary applications.
take two groups of schizophrenics - those
never treated with psyclwtmpic drugs and those previously
treated, and determine the efficacy of a phenothiazine in
both groups.
A) We may

~

If there are a, huge nusber of patients who have
been untreated with psychotropic drugs, we would like to
have the patients first stratified into two groups according
B)

to diagrosis: schizophrenia

and other diseases. In the
sdxiaophrenic group. we would like to suggest a test of
three forms of therapy: psychotropic dmg therapy alone,

�</text>
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                    <text>Decenber 23,

1961‘

Dr. Nemet‘tin Polvan
c/o Herr Y.L. Sehmradmer
Patrick Henry Village, mus-no D.
8. Lexington Avenue

Hegeninhhof

Sammy

- Heidelberg
'

Dear Dr. Polvan:

for your last letter, which
I have discussed the project at
was most helpful.
a.
and
we
length
are subnﬁtting proposal to the Natimal
Institute of Health Clinical Cmmittee . I am enclosing a
copy of our cormspmdence, for your information.
With all best wishes for the New Year, I retain
Thank you very much

Tumn and

Sincerely yours ,
Max

Finlc, M.D._

Director

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                    <text>October 12, 1965

mm

Dr.
Pglgm
Lunar-tin Cad. Bum Apt. 1711

Taliesin ..

Istanbul,

Tm
my
Palm:

Dear Dr.

ten you c: the start-us at w eollatmativs project .
Tm hasummtbatmﬁemmmrinﬁm,but
I

WMMMMMWthlmfm-ﬁm
We}: part without sea-1mg Mametim. Sines the we

'

advisable
mmmmmmymwﬁnm,ﬁwm
to wimdrw‘ this applieatim, in cedar that the project mule be

resubmitted in the
we

e: the
Cumittees,
1:9me
this appliem
quatier: “timingm
Wt
the status of the
utilities in

In diam-aim with the

been

titan,

m

when that. m

staff
not1-qu
we

W.

w

12mm. Thorsten,

that e Wmtative visit you me hr.
and see both

feeilitiu.

Beyulkem

to

w._mmmummmmwmemy
‘mdmlmmﬂmﬂmmitsatw
Hillhsinﬁurepemg
He
Wmfollwingﬁmmmmtiminﬁrmm
has mod that if his schedule mania, he will visit Istanbul

emitter
WWW,
Wtymmmtoywamamiﬁmmyisammhsd.
RIM.
mdﬂunp‘npe‘m
his
is not yet hamlets me he has suggested that he have thesemen:

Bayulm
meummtommmtwimm.
staff at hem imtitut-ims, sad
the facilities

me! the

new?

We

far this
It would be helpful if he ha an opportunity te
see seen of the patients we have never had preview dam treatments and be provided a cheeriptim of their histaries .
In edditim, we have
Dr. Ali Minor, cm of our staff
at the Pasteur-i Imtituts, me
visit we me Dr. Emmet, to discuss
ts
the mjeet ms to review with your staff psychiatrists the rating
scales md the mthods sf ovelmtim we proposed for the “My,
ea that we can pmvide the optimal smiles fer this mllabwatim.

�mmvwrvm

’57”

5w,

I?

mn'

{l—E‘a'y‘aﬁ

rt‘vywunvw‘uwx

-

u
v

r

x;

me“

12.1».

(”wwn’A-QBN-

Br, Polvm
Dr. Keakimr in e

~2-

-

of Istmbul Mwemity and had his
We:Will
has extensive
Urdworeity.

peyctdstrie training at

ts advise

October 12, 1965

He

inmdlinieeldmgpmgsmmdmhawseskadhim
as en te the weary edjmmnts in am methods for

mmletim fbwillwitstoym,butplmtobein
Istmbnlmmr be.

Mymwxymfdryowhelp. emitWthatwr‘
31:20::me yours ,
Max

Firm,PM).

Wessex“ of Psychiatry

mm
as:

133*.

9:".

Dr.

W
11:11

cm

�</text>
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                    <text>Dsoember 23, 1955

Dr. Neonattin Polvan
[martin Cad. 8mm Apt. 17/1
Taksim

-—

Talinham

Istanbul, Turkey
Dear Hr. Polvsn:

I regret very mush the musual oomplioatims with Dr. Crane.
that he would be able to make a site visit and
It
provide a visual image of your facilities. However, since there
are now very heavy restrictions in mm grant wards because of
the oomittments of the war in Viet Ham, I believe the best
strategy would be to mdertake a pilot study using such funds as
you may have available and attempt to obtain sou-1e small support
from plummutioal houses. It shmzld be possible to select
oummds which are still of interest to various drug companies
was our hope

TA

-A.

.

law”.--

uu'f‘wwwzerrl

»-:-anm-

sothattmymaymakethedrugsavailableatnooost.

"WWW"

letter you raised three questions. lbs first ,
the
testing of new «rounds in untreated schizophrenic
relates to
This
is a very important question and if you were
patients.
interested in most-taking studies of butaperusine, for owls ,
this study would be very Mlpful in answering questions which
In your

wm'.lwtc.Au-v

mpuszlingtoday. mismdisalmadyaooeptedinfimpe.
"new”

uncover, you were interested in testing
minds,
there are my that have been momtly proposed which we are
studying here. Parellel investigations mderteken in your
(Pfizer)
facility and in ours of such oanpoma as thiothirene
would
both
(Squibb)
enmthete
the
fltsabenuine
noting
long
or
be supportable studies.

If,

~—mW~chr4'erijwrrr4-1W

lbs second question, whether schizophrenia is reversable,
is a very ignorant me. Hmover, it does not lend itself to
an early simle mower. If we are anxious to obtain support
at own future time, it would be more helpful to mdertake a
study of shorter duration.

.

third question, of activating chronic schizophrenia
by hallucinogmio drugs, is a study which also has much merit.
However, we have many chronic schizophrenic: patients treated
Your

_

wpwv._r,,wnm,f

m,”

�Ir.

Polvm

-2~

December 28, 1965

for long periods available and such studies are

in progress hem.
Ifyeueouldmdertahetwopmm—thestudyofnewdmgsin
untreated schizophrenics and a semnd study - then such activation
projects would be of merit. Perhaps they should be planned in a
fashion parallel to our present pmjeete.
mm

-

-

mileyouesktheeethreeqmtima,my1poseefmmﬂﬁ

are the effects of new drugs in meted depressive cases?
Is them a difference in treatment results between: psycmtzwic
drugs and ECT in mtreeted depmssim? These two questions
mounting mtmeted depmsaives parallel the questions asked
in the drug and schizophmie study. me results of these studies
aould be of help in substantiating the value of such a study unit
What

Ietmbul.

If

any

the next

few weeks.

forﬁueﬂewYear.
Myouverymdlforyourkindmgm
wife
and
my best wishes for
Happy

Fleece

and

we mld be pleased
and working out the details in

of these projects interest you,

to assist in planing the protocol

mp1:

Prospem

1966.

you

your

for a

Sincerely yours ,
Max

Fink. Md).

Professor of Psymietry

MPucp

�</text>
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