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                    <text>M0,.“ -ﬂﬁ... ,w, mow“

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r.’ .v-’»F“:~g—ww

-.r ‘rVVS-rrln7v w. w»«‘ manna-wr- «rm-M

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August 13,

&lt;'wI—R;"?='r-rn'w

“m «ﬂu—w—

‘

196%

'Feseamh Gmnts and Fellowships Branch
National Institute of Mental Health
National Bank Building - Room 206
Bethesda 1%, ‘Maryland

Gentleman :
With regard

to the application

Mi

o72u9a03

and Ewan Psymophamaoology) , I am pleased to
advise you that wither I , nor my winvestigator,
Dr. Tamra Itil. nor the Psychiatric Research Potmdation
of Pﬁssouri, have made any oomﬁtmnts or obligations
(EEG

contrary to the patent policies of tho National Institute

of Health.

‘

Sincerely yours ,
Max

Fink,

M. D.

Principal Investigator

George A.

Ulett,

Vice President

Mme

M. D.

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                    <text>w... «1“.-sM-lw-rwm‘ﬂm‘4w‘ ‘rw'll‘mwme1w

..-—

w. mw

r

v

"ma-”u...

L. m“...

&lt;

r—JW

-. ‘.m,_.‘ w‘v‘rﬁ

June 22. 1965'

Commit Aocomting Offioo

National

Instituu of Mmtal Health

United Status Public Halt}: Service
Bethesda, Maryland 20 on

Gentlmm

RE:

Iii-8388431

M1~auau~01

bun

Immitngwiﬁxngardtotheﬁmds tohavu
Mic—8388

by us in grants
mind
to our
us have

‘m,

and MH-eusu.
621.8%

m Mulf of m-ansu-m and $22,320mind
for bib-8388.

Hatch 30. we
an additional advance
of $12,000, mid: has matted
not been received.
On

Rather than

file individml monthly cash

masts,
involwdis m1. muldymfmrm
sirmﬁnmnt
with a singhdudc in tho
of $26,156 which will
30,
mrthemlctimofﬂaeutwogrmtstm
1&amp;5.

wt

For iii-$388, the

total grmt

have monivud 822,320, leaving

PmM-Bhﬁu,

$37,892. it. have
Of 315,3“5.

a

was

332.6%.

We

bum of $10,320.

mwminmmmtof
mind $21,8u6,'1uving a balm
I

Insofar as both those grunts to this romantics:
being
to the
Missouri University School of Medicine effoctiw
July1,_) itmldbohlpfulifthisfumdatimemld

will taminate (the

wt:

mfemd

mist. its mounting this war.
Thank you

for your assistamu.
Sincerely yours ;
Fink, H.D.
Emcutive Dimctor
Hm:

�</text>
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                    <text>November 16 , 1966

National Clearing House for Mental
Health Information
National Institute of Mental Health
Bethesda, Maryland

200114

Gentlemen :

I

would be pleased

to receive a

copy

of the

new

bibliography "Studies on Electroconvulsive Therapy,
1939-1963" which was described in the recent issue of

the PsychOphaImcotagy Bulletin.

Would you also correct my address of record from
the Missouri Institute of Psychiatry to Dr. Max Fink,
Department of Psychiatry, New York Medical College,
5

East 102nd Street,

New

York,

New

York 10029.

Would it be possible to receive an additional
mm
of the Psychophwunacatogg Bulletin, Vol. 3, No. 3, dated
July 1956 for distribution to the Clinical ministry Laboratory
of this

Wt?

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

111ka

�</text>
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                    <text>August 18, 1967

National Instituta of Mental Health
Public Health Service
Bethesda, Maryland

Gentlm :
May I please have two applications
Service Grants (PHS~398).

far Public Health

Thank you.

Sincerely yours,
Fink, M.D.
ProfEssor of Psychiatry

Max

mfﬁqa

�</text>
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E

i
E

E

?
F
E

r
E

E

January 7,

1970

National Institute of Mental Health
5454 Wisconsin

Chevy Chase, Maryland

Gentlemen:
May we please have three sets of application fbrms for
Public Health Service Research Grants.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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1963

National Institutes of mm;
Division of Genoml Hudioal Sciences
Bethesda 1H, Maryland

Gentleman:
we

would appmciate
on General

the latest policy. and information

statmt
Rem Support mats.
We Md also appmciata a copy cf tho application forms
mmwadeilmgfwstnhWauppor-t.
Sincerely
Max

mac.

Dimmer

yam,
M.

n.

_

�</text>
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Decenber 18, 1963

Maxim].
Bethesda

Institute of

Plental Health

Maryland

Gentlemen :

ofofects

Ming the investigations
Wuuiﬁms on mug) behavior,
mated.

of different

no patentable inventions were

Sincerely yours,
George A.

mart,

M.

D.

Principal Investigator
Mi 07071—61

ﬂax

Mf‘mw

m.

M. 1).

Executive Director

�</text>
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                    <text>January 3 , 1967

Assistant to the Director
National Library of Medicine
8600 RockVille Pike

Bethesda, Maryland 20014
Dear Sir:

grateful for capies of the pilot issues
of the Bibliogaaphy 05 Medical. Review , recently published
by NLM and as described in a recent issue of Science.
I

would be

Thank you

for your cooperation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MI-‘zkp

�</text>
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                    <text>April 2, 1971
National Library of Medicine
Bethesda,

Maryland

Gentlemen:

I an anxious to obtain a

copy of the following volune which

is not available at the ﬂow York Academy of Medicine or the major
medical achool libraries in the city:
Monographicn Ans Den Gesamtgebiotc der Neurologie
und Psychiatric. Vol. 68, 1939. Stringaris,

It is

an essayy on hashish.

If this in available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

M.

�</text>
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April 2, 1971
National Library of Medicine
Bethesda,
Maryland

Gentlemen:

I am anxious to obtain a copy of the following volume which
available at the New York Academy of Medicine or the major
not
is
medical school libraries in the city:
Monographian Ana Dem Gesamrgebiete der Neurologie
und Paychiatrie. Vol. 68, 1939. Stringaris,

It is

M.

an essayy on hashish.

If this is available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

�</text>
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                    <text>Juno 7, 1965

National Mann]. Phalth Clearing Baum

Rattan}. Institute of
Bethesda, Haryhmd

Attention:
Dear

hutal Hulth

h. mum:

lamina:

We am begirming a mviw of weigxt clung“ associated
with psydwtmpic drug mamm, and the relation of such
in behavior of psychiatric patients ..
changes to
Has the Clearing House rcvimd the literature of this subject?

Mmt

mlevmt dasaiptom would be wig“, weight change, gain,
loss. psymatmpic drugs, mutant. psychosis. Mm. md

The

Wt.
Mywvery

much

fwyourhclp.
Simmly yours,
D.
M,
Professor of Psychiatry
Max

Hfzkp

M.

�</text>
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                    <text>June 11, 1971
Dr. Mickncl Rosin
Droxel U31V0201€y

Philadelphia, Pennsylvania 1910‘
ncnr Dr. Nagin:

Thank you for your invitation to the 1971 Conference.
Since working with Dr. Itil in St. Louis in 1963—1966, I havn
not maintainod an active program of sleep scoring. Dr. Itil
baa unstained his intcrost, and I cuggclt you invite his
participation. Hioonddroao 1. Missouri Institute of Psychiatry.
5500 Arocnal Street, St. Louis. Missouri 63139.

Sinccroly yours,
Ha: Fink, M.D.

Pratt-cor of Psychiatry

Mrzkt

�</text>
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                    <text>July 9, 1971
Br. Jack Hehor
Mental Health Materials Center, Inc.
419 Park Avenue South
New

York, New York 10016

Dear Mr. ﬁsher:

associate, Richard Abrams and I have read your invitation
believa we can assist you in your mission. As I will be away
much of the amour, Dr. Abrams is willing to work with you and I
and

Hy

suggest you reach him at 360-6746.

Sincerely yours,
Fink, Mm.
Professor of Psychiatry

mu:

�</text>
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              <elementText elementTextId="92304">
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                  <elementText elementTextId="105833">
                    <text>March 1. 1970

Dr. Ivan R. Reilaen, Ph. D.

Loma

Linda ﬁniversity

California

Dear Dr.

9235a

ﬁeilsen,
Thank you

for your inquiry abaut our

EEG

analygﬂa

taking the liberty of enclosing a copy of tha
letter I wrote today in answer to a similar inquiry, and trust
it will answer your initial questions.

syntam. I

am

If there are specific problems that you face in
the application$ at yaur canter, we wvuld be pleaseé t9 try to
£3313! in any practicabla way.
Sincerely yours,

Fink, H.D.
Professor of Paychiatry

Max

mf/

�</text>
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                <text>Correspondence to: Neilsen, Ivan R.</text>
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                    <text>April 5.

was»
We.
Am,

Ir. J.

A. Vallejo

illHarm

Calla

Mid. Spain
Dear

103

1966

Mam
of Psychiatry

m. Haj“:

WmﬂmemmmMmrmlpfnlinm

Wormwormmnmm.
an abstract ”War halyaiaofmefor WWW"
hummwforpwticipaﬁminﬁmsmimmmimdby
Dru.

mmmmmminmdﬁauy.
mmuwt”axolimrgic Wafﬂu'rrumntof
Dopamine
W“ is a free Mania:

MWof“mminPsydnplmlow‘-Dimsim“

hamstmtofapmbablcfmofmydisweaimsofﬁn

papmbeingpmaenudmlierinﬁnday.‘

Sinaemly yam-s,
Max

Pink,

24.1).

Professor of Psychiatry

Waltz:

�</text>
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                    <text>April

15 . 3.96M

Dr. James 3. Nelson
Washinton University
Deparmant 0f Paﬁwlogy

WWW

Euclid Avenue 8
St. Louis . Missouri
Dear Jim:

Enclosed are three copies of the Application whim
you submitted to NIH.
have received pennission from the National

We

Institute of Mental Health to purchase the. electrophm
cais- equipment, and will put that pmohase W31 in
the next few days, and I hope to have that equizment
available within a

few

twee.

Sincerely yours
Max

Pink,

Director

MI“

bw

Examines

8,

M.

I).

1

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                    <text>mq:"u 5"“ "‘.1m‘-I‘qm§&lt;vvm

Wr-Vx-I"'IV' -—-

"vault—'7-

_-

m'RF—"r-Fy'

arm-N.

.

1." m’,‘ vmv

.

raunwmw—q-v

yer

February

"M.

8,

w-rm‘

\w‘n-«m’ﬂ .,

“Juan-vvgg-‘r'v-

-

xrrﬂ‘I-a.‘

quwv-

1988

John C. Nemiah, M.D.

Editor, American Journal of Psychiatry
1400 K

Street, N.W.

Washington, D.C. 20005
Dear John,
Thank you for your and Morrie‘s replies on the Arnold Lieber letter. i am
satisfied that suitable review requirements have been met and that the difference
in opinion is just that..
While lam not likely to advocate or use the treatments described, I also
am not in a position to present data on the risks or benefits of such a complex
regimen. It would not raise the level of discourse to state that such treatment
remain unproven, so i shall not send a response.
I am grateful that you and Morrie have taken the time to answer my query.
Thank you and my best regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

.

mum

van-”m.

~

_

�</text>
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«am--

September 28, l967
Dr. Robert P. Nenno
Medical Director
New

Jersey State Hospital
New Jersey 07746

Marlboro.

Dear Dr. Nenno:
I have read the information which
you made available
me
regarding the Marlboro State Hospital with a great deal of tointerest.
I have discussed this research
opportunity with two of
former
associates at the Missouri Institute of Psychiatry. Dr.myNafi Kiremitci
has indicated an interest in this position and may write to
you

separately.

I met Dr. Kiremitci when he was an
assistant in
York State Psychiatric Institute in l96l. He psychiatry at
returned
Turkey to complete his military duty and was appointed to the to

the

New

Missouri

Institute of Psychiatry in July l965.

He has been actively involved in the
research programs there.
especially in the studies of new compounds as they effect
behavior
of the severe mentally ill. He has an experience with populations
similar to those at the New Jersey State Hospital.

has recently completed the requirements for licensure
and is scheduled for the examinations of the American
Board of Psychiatry at their next meeting.

in

He

two

states

I believe he may be helpful in your program and
trust that he
In the interim, a copy of his curriculum vitae

will write to you.
is enclosed.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>August 21, 1972

Horritt

Dr. H. Houston

Association for Rssssrch in

ﬂames

and Mcntsl

722 Wast 168th

New

York,

ﬂow

Discus. Inc.

Straat

York 10032
RE:

Richard Abram; PM).

Merritt:

Dear Dr.

I

msbcmhip
a plasud to propose Richard Abrm,Moots}.forDisossa.
I

in the Association for Rssosrch in ﬂorvous and

have known him since 1968, when ho rejoined tho

"11.1).

staff

as fallow.

intsrostsd in ECT. and bacsns tha projact director of our
evaluations of. unilatoral and bilateral 301'. as nsds important contributions to thst evalustion, and has continued his snthtsissa for
this problem.

Ho

wss

prassnt,
biological studias,
At

ho is sctuslly angagsd in s vsristy of psychoand I an contidsnt ha will contributs to tho

lusting: of the Association.

Sincsrsly yours ,
Max

Fink,

21.1).

Profusor of Psychiatry

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                    <text>w»

”pm—«r

r
-

1

.

,

Wr&gt;mwmwmlwmma.—Vvauu

—v

v

.wnw.

,

.

v

W. -__

u...

-. ,__,_...__.,.

—

.—.

“.4...

7...-..” w...

.

(

July 15, 195a

Kurt Nuaabann. M. D.
Spring Grove State Hospital
Baltimore, 28, Maryland
Dear Dr. Nuaebauu:

In response to your letter of July 8, I am pleased to enclose
copies of the articles which you requeuted.
Please give my best regards to Dr. Knrland.
Sincerely yours,
Fink,
Director

Max

ur/gb

he. ‘2

M.

D.

—

...

... ._7

1

.

...

..

,.

�</text>
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.-

J

wwwnwwur...

vwrwm..,.,w--r

“WWWE,”

December 21,

‘,
.m

_

"wr'

«wan-av

.

meuM':

m’:

198%

Prof. Dr. P. Netter
Fachbereich Psychologie

Justus-Liebig—Universitat Giessen

Otto Behaghel-Strasse 10
0-6300 Giessen

W.

Germany

r-

ww-

Dear Prof. Netter,
Thank you for your kind invitation to write a review of the usefulness of
pharmaco—EEG studies to predict clinical pharmacologic activity of drugs. While I

am interested in writing such a paper, I regret that lam unable to carry out such a
mission in the near future. I have just accepted the responsibility to edit a new
journal, CONVUSLIVE THERAPY, with its first issue due to appear in March 1985.

There are others who are known to you who can carry out such a mission
admirably, notably Dr. Turan [til at the New York Medical College, Dr. Milan
Matecjek of Sandoz (Basle), or Dr. Walter Sannita of Genoa.
If you do not get a satisfactory response by the summer, try me again.
My best regards.

Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

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                    <text>1963

July so.

Wnlztm
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New
Mr.

.

Briana.
Dam Bill:

mm

I must Ape
few wank: have how q

W

mim

Gantar

as for: the delay 5:: writing you. The last
tn busy in exploring the applimtim of the

mar 3.710 system.

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us tawny}: with am of your samba

Imtoﬂailyeamy,

( and
‘

me

also

mam): you

form

for pamitting
logic).

pmgmm

udingmmmnentsontm

probing of period analysis and :1'am taking the Ilka-2y of enclosing
the when for you.
_

.

SW3; yawn,
Max

imam

m.

Pink,

Dimatox‘

M. D.

�</text>
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                    <text>July 15,

1991

David Neubauer, M.D.
Francis Scott Key Medical Center
4940 Eastern Avenue
Baltimore, MD 21224

Dear Dr. Neubauer,

theory

It was kind of you to send the reprints and citations on chaos
and EEG. The reprints arrived fortuitously when I had a visiting

scientist/electroencephalographer from Genoa, Dr. Walter Sannita, who
has been interested in the theory as another way to analyze EEG signals.

assume the concept is of interest as a novel way to reduce
form for further study (as in pharmaco—EEG, for
example) and as a basis for understanding the origins of the EEG. After
reading these reprints, I am reminded of the search for other techniques
to reduce EEG signals to numeric form: Drohocki integrator, pattern
analysis, shape analysis, period analysis, power spectral density are
some methods that we have used. After some extensive (and expensive)
computer comparisons of three of these methods, we realized that each
method is based on a massaging of the original numeric digital signals
as presented by the amplifiers, and therefore, one system must be
related to every other system; and that they can only be compared on the
I

EEG

signals to numeric

basis of efficiency, not

for

an

on ’meaning’.

I cannot contribute thoughts to whether chaos theory is useful
understanding of the origins of the EEG.

studies.

Again,

my

thanks and

my

best wishes for success in your
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>Bummer 27, 1953

Dr. Harry

New

Pﬁmuri Institute of Psychiatry
81:.

Louis, Nissan-i

MW?!

Atthistimoftmyoar,lwiuhtotaketrnoppmmtymo

A

thmkyouforallmhelpandformintmstinﬂmdevolopmnt
of the Institutn.
Effective Jmuary 1. 1961: I am asking that yew salary be
changed to $15,500 per yew.
Hy best aims for the New Year.
Sinmmly
Max

Pink,

Director

yum,
M. D.

�</text>
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                    <text>43am

January 16, 196k

Dr. Harry Neubauar
snoa Arsenal Street
St. Louis 39, Missouri
Dear Dr. Ntubauar:

It is with great pleasure that I appoint you to the Pbyahiatric
Bazaarch Fbundarian of Missouri in the position at Suuiar Research
Scientist offhctive January 1, 196a.
Fbr

tbs immediate present, I

would be

grataful if

continua your'participation in the study of

Sincanaly'youra,

m m,

M. D.

Executive Eﬁxector
Hraaw

you would

new compounds.

�</text>
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                    <text>October 1. 1964
Dr. Harry ﬁsubsusr
Missouri Instituts of ?syohiatry
St. Louis. Missouri
Dssr Harry:

jolusd us whoa the Institute had just boon born sud
in its swsddliug clothes. You struggled as us triad.
I bslisvs sucusodsd in rushing through our suckling and
waddllng poriods. I think you hsvo scan. during the last sightv
ton months, tho Institutc lssxq1ng rapidly and perhaps crsstlvs~
You

was
and

still

ly producing information on

its

own.

I on most grstsful for your patience, uudsrstsudlng and helpful
participation during those difficult psrtods. I am very proud
of tho work that you, 8am and Tursu boys-accomplished and hops
that the Institute will be shla to successfully build on this
bass in tho yssrs to come.
to: first "gradusto" of the Institute, I look forward to
following your career with n.3rsst dual of tutorsst. With sll
best wishes and my personal thanks.

As

$1ncorsly yours,

ﬁst Fink.
r.nituotor

_uf/ls

M.D.

�</text>
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                    <text>October 19,

Harry Neubauer, M.D.
#3 Aisgill Drive, West Danton
New Castle, Tyne England

196%
.

Dearﬂan'y:

Byrm,theexperimoesintheUnitedStatesand
smart-lazy. ImpetlmtymmvisitstoWashington, Boston
andNewYoﬁcgaveyoumchtothinkmthevaﬁetyand
wealth

themy differencesinoulturemdolmnteambeooming
of the studies in the Wood States.
'Ihe

mustmtive

Wm Cannittee

of the
Imtitute has considered yew: mqueet to use the data
obteinedfmstudieswithSamGemmnand'I'urmItil,
while
at the Missouri Institute of Psychiatry, for the fulfillment
of requirements for an Md). degree. I an pleased
to tell
youﬁmattheomudttaehasappzmdyomueeofﬂmdatafor
the

-

ompletion of an

FM). thesis. It is understood by the
mtteemattmsmesiswillnotbepublishedandwillbe
used

primarily for the
of the oomrittees of
the University and filedmidemion
in the University library. The
Cwmittee requests, however, thetaoopyofthethesisbefiled
with the Dixeotor of the Institute
as soon as it is available.
In the event, that you wish to publish
the results of these
studies. the mitme requests that the rules
of the Institute,
requiring prior submission of all publications to the Research
Camittee be followed.
'

Wewishyouluokinymmﬁwsis, andlookfoxwand
toseeingyouagainﬂxie spring.
.

Sincerely yours.
Max Fixﬂc,

Director

mills

Ir. 3. Gemhm
c.c.: Mrs.
A.

Wetzig'

14.3.

�</text>
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                    <text>May

27, 1965

Madam. h. D.Aisgill Drive, West Dmtan

Hart-y

# 3
New

Castle,

Tyne England

I must you we actively enjoying your work in Newcastle. As I have
admin, I sssm you we still preparing the trasis for your

not heard

doctorate, in addition to developing your

m prom.

I an aritin‘g tacky witha some of disappointment after reading your
report ‘mitm and its Antugmim in a Maud Psychiatric Population."
Disappoinmm mt with the text mic}: is intmsting. but with the

disamR'tesy ulﬁah you and Ir. Gemini have volitiamlly enmibited. One
disaourtesy has already been mated. for I have written to Dr. Serum
expressing the disappaimmnt of tho Formulation that their support of this
work was not
In response to the Pamdetim's letter, he has
indicated (in the oapy sen-t to me) tint the following aolamledmnt will
be insatsd in the published text:

WW

"Wedsouishtotlmrkthsf’syahiatricﬂesm Fonda-

tion of

Msmi for their support."

Imrstyouwillinsertthiseaiamlsdgnntinthegelhypmafs,mdineny
otlwmportsofymwatkinsmlcuis.

Mottlauotkinthispmmtookplsao intheEBQlebamtory

‘

'

utilisingtlufeailitiesendpersamal supportedbythemmsm
"ms and Hut-n Psyohaphumaoloy" (arenas). Insofar as the United
sates Public Health Service should be audited with their support in
these studies, I an requesting that you acknowledge the support of rid-072w
'inthisropm't, mWﬂaMdstemybepublistaepamtely.
But. thruismttmrealamlodmntwhiahsppaars tobeamitted. This
studymaonoaiwdandsuppartadbyhr. Itilmdnyself. Ymhiwtheaerly
reports or arm studies with entiaholinergicdmgs which provided the basis
for the aallsbomtian sought and developed by my in establishing the pram
was crystallized in a joint
an antiohalirargia drug» min
(Mi—98597
«— Antagonists to
with
Br.
Wuhan
application
ma grant
Antiaholimmiamummy). 'lhe strains of Dim and its antagonists,

:30th

mdelso
endﬁabalnviotulahdMamumiansmpartoftrntpmm,
"me mad
of the
project

Hum Psychoplnmaoloy”

�12-.

Wow

~2~'

my 27.

1955

trumicss
Atﬂdstia.towbnshm
ummmlomlsdgingmlyﬂu
”mop.
"WWollﬁslem
W.Mtﬁngrsfm
smimMssimsMamhoftaotand
amWaummxmhu

mmmtedmommmmmwwtw
Notmhowmsowytwwmmalsoamhof
in
ot’sll

momma.

31mm.

you

Mommisadiffmtspiritmuinmin mm.m1mmis
'_mllwmmiws.xwiumtdotai1n~.m'sdifﬂcultiuwiﬁx
hispdwﬂuimm,forﬁnymﬁaomuhoishnvingm. Porn-auto

Whimuymmcbiminmm
Whipvﬂohommlymoym

ofthionpwtistofollm

mm.mitismmssing
younow.
Wimraithinymmug‘ity,1mwdngthismmdmt
ofmmdimctlymmmmsthmyoummmofwmammals». Ilozowyou

powwow _rauﬁmhipmmhwuinﬁﬁsmm.m1also
mammm,m
Mmmwmmmmmmmmmmtm

memmormmmmmmmwmm.
wmmmmmmmkt.

Shmmlyyows.

m
m. of"a Payohkw
Profs-user
Do

WP

�</text>
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                    <text>July 15, 1982
Division of Neuropharmacologlcal Drug Products
Food a: ~{Mug Administration
5600 Fishers Lane
Rockvllle, Maryland 20857

Gentlemen:
REF: 1ND 12,987

ACTH,-9 (ORG 2766)

Enclosed is an amendment to 1ND 12,987 for a clinical trial of this ACTH
fragment analog in the treatment of patients with pituitary hormone deﬁciency, to
be undertaken by Dr. L. P. Kapcala of the Division of Endocrinology, Department
of Medicine, Cleveland Metropolitan General Hospltal. Copies of his protocol,
consent forms, and curriculum vitae are «closed.

Sincorely yours,

“wr

a:,:yuw'\'wvwnyqu'r:-

"'

mem

Max Fink,

Ml).

Professor of Psychiatry

�</text>
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              <elementText elementTextId="63852">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                    <text>re

a..- 1.."

mas—u.—
,

"mm-W...”“m" :,

WW...

4vw—v '1"‘WVW1"H&gt;
i

1 :r. um ,_,»¢-

.u.

"WINK“Zhuuwn'ﬂmv—n-vwnvi
~~1wtcn¢ ...... «wavy-wane
4

.

.-—n ,
,

n... ..

,

..w .,:-» -

Ww'

rm sunmgv

w...-

u...» ”nun,“

.,., . _,_, ,, "nu-ww- vw.

1

,,

7v:

,-

WWI

v&lt;vugmvvzvu~m

i

:

T0:
FROM:

Adsinistration,

New Community

Metropolitan Hospital

Fink, M.D., Professor of Psychiatry

Max

SUBJECT:

Hental Health Center,

EEG LABORATORY

- Metropolitan Hospital

DATE:

8/29/69

mental Health Center

The development of a Community Mental Health Center

requires

the application of the best available methods of diagnosis and
treatment to reduce the time for treatment and improve the results of

interventions.

Based on

this premise, the Center is required to

have a diversity of services.
During the past decade, the role of brain function in mental
illness has assumed a greater interest and techniques measuring
and
changes in brain function have found application in diagnosis
management. The changes in brain function are measured principally
by psychological performance
Much
EEG

research has been done

analysis are

now

tests and by the scalp recorded EEG.
and clinical applications of quantitative

available in a

few medical

centers. In our Department,

analysis is available for research purposes,
has been limited by contracts to patients in the Narcotic
Addiction units and the Psychophsrnacology Clinic.

quantitative

The

EEG

and

clinical applications include:
1. Diagnosis of therapy resistant psychosis.
2.

Determination of adequate levels of antagonists in

the treatment of heroin addiction.
3.

Classification of brain injured children in the
Mental Health Clinic.

4.

Selection of drug therapy in psychotics.

..‘..‘-..... --- -

�"nu-rm
If the

m m,‘- ”mi—,ﬁﬂwmlw"
‘sw

.

equipment were available,

these lethods to

we

propose to apply

all pstients adnitted to the

Mental Health

Center, and for selected out-patients referred by the

staff.

Steffing funds already exist in the clinical staffing contrscts
available to the Department.
The

techniques used require careful recording of the

brain waves, storage
and

reporting.

The

tape, analyses by special programs,
individual pieces of equipment and their
on

functions are:
Electroencephalograph (Grass 78) and Couch: Used to
amplify brain waves.

The Grass

instrument provides signals

specially suitable for analysis since they
"chapper" type amplifier.

(The

do

not use

3

Offner, Medcraft, Gilson

units, although cheaper, are unsuitable).
Tape recorder (Ampex SP 300).

configuration, 1/2 inch tape.
analysis.

While Anpex

Seven channel,

Used to

FM—IRIG

store signals for

is reliable, other

vendors

may

be used,

as Sengemo, Honeywell.

Oscillator (Hewlett-Packard

2026K).

To

provide s standard

for tape units, especially for amplitude comparisons.

.-n»r.—--mv.w~-———.-~way—Fwwvuw‘

�“yaw-"T

-

I

A

.,m'—

A

V

my..."r.rwmmmMW—wqw—uuvww-«m-w—.m

vwn-a—Wn

&lt;w—w-w--—.—w-u~

wry—v»

Oscilloscope (Toktronix RH 564. dual channel). Monitors
the recordings on tape. Either single or dual been are satisfactory.
A

store's

scope

is necessary to allow its use also for photographs

of the analysed output.
IBM

1800 Process

power and amplitude

but

much

Controller. Analyzes

EEG

waves by

analysis. Other instruments are available,

less efficient. This device. though expensive, is

the one for which a library of programs has been written and
can be used immediately.

flexible

and

completed in

require
2

Other computer systems would be less

programming.

(Our programming has been

1/2 years.)

wm-w

w-vw

-r-

-1"

period,

Respectfully Submitted,
Fink, M.D.
Professor of Psychiatry
Max

�m"—

V

_

V

.1-I»'

“—3.2".

-

u-mv—nmz‘w—

EQUIPMENT FOR EEG RECORDING

Grass Instrunsnts
Quincy. Massachusotts

Roo- 4-17

1

console 7816p43.75 with 763800A-1230-16P

1

power supply 67RPS-A

1

Signal markers
8

HT7A

885.00

$

800.00
($165

as.)

botwson channels

and 9

165.00

8

Oscillogrsphs 6080 ($140 as.) with 1" spscing

8

830 Data

1

78MPRr8

1

678525-12 canneric pushbutton electrode

1

78THIEB ZO-N

amplifiers

1120.00

7P511A

3200.00

Master record playback

150.00

w”

,,

v—r-ﬂmrwzmyw—v

selector

400.00

high impedance electrodo board,

300.00

standard numeric

,_

--..

TOTAL $

.‘t-w-I-v-VWW'gw-vm‘

7020.00

.WA7F_

~._-_-w—w,&lt;

Room
1

.mrw..v~.—

é~17
Anpcx Modal SP-300 Record/Reproduce

1/2" wide tale,

»

7

track,

7

portable,

amplifiers

1

Mbdcl 704 Head degsnssor

l

Rsnotc control table top unit plus 30'

:Wwwm‘

8450.00

$

9.95
74.00

w

.-

cable Cat 596520-01

mum

&amp;

#4050100-10

-

m"

W1

TOTAL

—-

mmwm_mnmmlmww'r

1

Tcktronix dual bosn OscilloscOpe

1

Hewlett Packard Oscillator,

1

Inwood Couch H-4900, antique white (Scully Wslton)

RM

564,3A72, 2367

ZOZCR

$

8533.95
1250.00
330.00
144.00

�EQUIPMENT FOR

886 ANALYSIS

-u-———w—-

4-22

BOOM
~m-a-

rr'

may

.7,

.

One

rm...

-

IBM

1800 Process control system consisting

of:

m

WW

lSOl-Zcb

Processor controller

1816—1

Printer-keyboard

1828-2

Enclosure

1851-1

Mnliplex terminal

1856—1

Analog output terminal

23lO-A2

disc storage

1442—6

Card~read~punch

1443—1

Printer

Coat, single:

Approximately $168,000.

ZRWW”W"'

13w";-

rv-

”Ev-WW"

rwuwwrr-rv

m—u-wr-rpm

gwm

(For detailed specifications, ploace

call

Dr. Max Pink or

Dr. Donald Shapiro, New York medical College;
IBM,

or,

475 Northern Blvd., Great Neck, New York.)

Dr. Wayne

Joatrand,

�</text>
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                    <text>v

“x ~'1L'erwi-lwl~."r"

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.-wa-r=ww-uw—wmmurxar

W

&gt;

,'

Java-v:

~

.

'.

w

”.37"

_

'I'Iwm'xa"1- 1 .Wu nay-rur-

October 28, 1969

Editor

England Journal of Medicine
lO‘Shettuck Street
Boston, Massachusetts 02115

New

Dear

Sir:

Pitts

and McClure (N.£ng.louh.Mcd., 1967, 311; 1329-1336)
reported that intravenously administered sodium lactate precipitated
a severe anxiety attack in 93% of individuals diagnosed as anxiety
neurotics but in only 20% of normal controls. They were also
able to minimize the effects of lactate by intravenous calcium.

undertook a replication of this study, using their
techniques and, with their couperation, their lactate solutions.
In five patients with lactate, each patient covelopcd acute
anxiety between the 3th to 12th minute of infusion, peaked
at 15 minutes, and remained seVero for 15 to 30 minutes.
Each patient experienced "after effects” of irritability,
dysphoria, tension, fatigue and weakness For 2~7 days.
We

to lactate/calcium was similar to lactate
alone, but significantly‘less in intensity and duration; and
there were no “after-effects”. There was no patient response
to dextrose/saline.
The response

In feur control subjects, the response to lactate was
characterized by tachycardia and restlessness, but without
anxiety in 5 subjects, nor ”after effects“ in four. Anxiety
was elicited in one control. The controls become drowsy and
bored with lactate/calcium and éextrose/saline.
Ac

with

Pitts

able to correctly

and McClure, a “blind” investigator was
name 25/27 solutions (92.5%); the patients

13/15 solutions (87%); and the controls 6/12 solutions (50%).

In concurrent scalp recorded cloctroencephalograms, we
observed changes with lactate in the patients, not shared by
the controls or by dextrose/saline and lactate/calcium solutions.
The EEG exhibited increased beta and decreased alpha abundances
end a decreased alpha amelitude. These findings are consistent

with the

EEG

changes usually seen in anxiety

states.

�Editor,

by

New

Eng.

J.

-2-

Med.

lactate are well summarized
would also add to their formulations
these observations have two interesting applications. A

Hypotheses relating anxiety and

Pitts

that

and McClure.

We

lactate tolerance test provides

Twwﬂu.

October 28, 1969

a group of mentally

ill

with

an

common

means of identifying
characteristics of anxiety

objective

neurosis, for both therapeutic and prognostic trials. The
antagonism of calcium to lactate precipitated anxiety and its
successful therapeutic trial (Pitts, personal communication)
suggests that other anti-anxiety agents may be tested using

'

u:
-

this

model.

‘

Sincerely yours,

.~.

3.:

”WW

uwna-w

P".-

5“an

Fink ,

:‘I

o

D

e

'wzawr-mxz‘

.

.mﬂm’mﬂP'W‘

Michael Alan Taylor, M.D.

Jan Volavka,
MF

:kp

M.D.

�</text>
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                    <text>School of Medicine
.
D epartment or PSychIatry and Behavioral Science
.

September 23, 1993
Medical
New Mexico Board of
PO. Box 20001
Santa Fe, NM 87504

Examiners
'

Gentlemen:

William Turner for
the application of Dr.
of
in
support
Bill for more
writing
I am
Mexico. I have known
New
of
State
the
in
medicine
then as a researcher at the
Island,
licensure to practice
in
Long
clinician psychiatrist
member in the
than 40 years, ﬁrst as a
1973, as a fellow faculty
since
ﬁnally,
and
Central Islip Psychiatric Center, School of Medicine.
at our
Department of Psychiatry
who have
dedicated cadre of patients
with
a
clinician,
them
Bill is an outstanding
and has been honored by
groups
support
in
patient
active
is
with special interests in the
been helped by him. He
researcher,
outstanding
communit He is an
as a leader in our
and in psychopharmacology.
genetics of mental illness
maintained continuing
active, alert, and has
Despite his age, Bill is
and students.
relationships with the faculty
.

without reservation.
I commend him to you
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

A

:7

I”

I

,

CASELLES
New York
Count-y
Suiiolk
No. 5.6775616.
luly 31. 19
Term wires
DCROTHY L.
01
791101-10. State

NOTARY

State University of New York at Sto
11794-810:1y
Stony Brook, New York

516-444-2990

Fax:

516-444-7534

BFOOk

�</text>
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                  <elementText elementTextId="106972">
                    <text>February 21. 1975

Secretary

Committoe on Admission
The New York Aoadomy of modicine
2 East 103rd Street
Row York, New York
10029
-

‘

Dear

sir:

have known'Prof. Torah Itil since 1958 ~ first as a fellov
scientist; than from 1963~1966 an an nauooiutem at the Missouri Instituto
of Psychiatry; anﬁ since 1966 as a friond and colldborator. I am.vr1t1ng
to ruconmnnd him for modbcrshtp in the Acadamy.

I

1: an outsttnding neurophyuiologint, who has made significant
contribuxions to the quantification of EEG and its application to classia
fioaﬁion of paychonctivn'drugs. ﬁe has keen clinical Judgment and is
internationally known for his evaluation: of new psychoactive substunceu.
Eu

patients.

Ho 13

I

a fins teacher and 1: wall liked by his coavorkorn and

eammond him

reservation.

to your consideration for tollovnhip. without
,

‘

Sincerely yours,
D.
Fink,
m
Profhssor of Payehiusry
M-

MF:od

,

�</text>
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                    <text>4.:

6%”

“--

n
-&lt;&lt;

.-

December 11, 1975

cw!'\“"mqw

5—:

Secretary,

New

2

Committee on Admissions
York Academy of Medicine

East 103rd Street
City 10029

New York

Gentllunn,
Yolles,

I ea pleeeed to second the nunihntion 0! Stanley P.
a Fellov of the New You! Academy of Medieine.

M.D. en

I have known Dr. Yollee for more than a decade, first
in his role as Director of the Setilnel Inetitute of Rental
Heelth, end since 1972 as Cheirmea of this Department of

Psychiatry.

He is an outstanding physician. edm1nietre$0r, end e
hnneniet. I believe we would‘ve hencred to count binmuons
cur Fellows end I em pleased ta reoamnend his edniueipn. gj.

Sinceruly ydufq, ;?N?~vﬁ=

.ppi
ychietry

Fink, M.
Professor of

Mex

w;
i
I

!

MF/mr

‘

‘
&lt;A..r—w-~.

«-

.

�</text>
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                    <text>June l3, l968

Librarian

York Academy of Medicine
East l03rd Street

New

2

New

York,

New

York

Dear Madam:
I would be grateful if you would permit Dr. Robert Levine
to work in the library during the hours open to Fellows as he

is working

on a

If he finds
his doing so.

project for

it

me.

necessary to take books out,

I would approve

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>August 20, 1968

Librarian
New

2

York Academy of Medicine

East 103rd Street

New

York,

Mew

York

Dear Madam:
I wouId be gratefu1 if you wouId permit Dr. Rhea Dornbush
to work in the Iibrary during the hours open to Fe110ws as she

is working

If

on a

project for

me.

it necessary to take out books and journaIS.
her doing so.

she finds

I wouid approve

Sincerer yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>September 17, 1968

Librarian

New York Academy of
2 East 103rd Street
New York, New York

Medicine

Dear Madam:
would be grateful if you would permit Dr. Richard Abrams
to work in the library during the hours open to Fellows as he
is working on a project for me.
{gﬁL7‘€3£39§xxR

I

I

If he finds it necessary to take out

would approve

his doing so.

books and

Sincerely yours,
.
.-.~.

rnmn

Fink, M.D.
Professor of Psychiatry

Max

mun-wrung"

u
'W

ml.

:14

..
rr.

wwnrma

;.s.

WWW-

1””

.

_—.u a, . ,

journals,

�</text>
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                    <text>January 9, 1967

Director
New
2

York Academy

of Medicine

East 103m Street

New

York,

Dear

New

York 10029

Sir,
for your kind invitation to an open
I look forward to attending and meeting

Thank you very mach

house on January

the ﬂouncil.

2%.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

.

�</text>
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                    <text>ﬂ

August 1h, 1962

New

York

Host hS
New York,
2

Bout

State Education Department
Street
New York

Sir:
Would you

mid-August from

kindly changa my address of rocord as of
Hillside Hospital to:
Max link, H.D., Director
Missouri Institute of Psychiatry

St.
St. Louis 39, Hiaaouri
Shoo Arsenal

thank you.

Sincerely yours,
Hrlgp

ax

n

,

. .

�</text>
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                    <text>March 27, 1967
Box 26235

New York Times
151$? Broadway
New York, New York

Dear Sir:
The Department of Psychiatry of
embarked on the development

recently

this Medical College has

of a computer facility
focussed on the problems of the analysis of physiological
signals . For this purpose, the laboratory is being equipped
with an IBM 1800 system. It is anticipated that the College
will, within the next eighteen months , expand their present
computer

V

facility to a larger unit.

-

The equipment for the Depmnt' 5 computer center is
to be delivered during the first week of May. We are now
appointing pmgrarrmers. This will be a small laboratory,

consisting at

your

Ext.

its

staff members.
If this opportunity interests you, I would appreciate
calling my secretary for an appointment at 369-7900
2147.
naximn of 8-11

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

M'r":kp

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                    <text>March 27 , 1967
Box P119

York. Times
1547 Broadway
New York, New York

New

Dear Doctor:
During the past few maths, we have developed a study program
in a camnnity mental health center dedicated to an unders
of the problem of narcotic addicts. While the principal emphasis
in the program is in the pharmacology and psychology of addicts
and the treatment of their emotional disease, the physical
concmitants of their illness have become an important interest.
,

In the continued development of this program, we are seeking
the appointment of a physician with an academic background who
may accept the responsibility for the direct medical care of these

patients.

'I‘hestudyprogzmisintheDeparmentofPsychiatryofthe
- Metropolitan Hospital Medical Center.
If this Opportunity interests you, I would appreciate receiving

New

a

York Medical College

copy

of your curriculum vitae.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MFﬁcp

�</text>
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                    <text>March 27 , 1967
Box 214832
New

York Times

15% Broadway
New York, New York
Dear Sir:
The Department of Psychiatry of
recently embarked on the development

this Medical College has

of a computer facility

focussed on the problems of the analysis of physiological
signals. For this purpose , the laboratory is being equipped
with an IBM 1800 system. It is anticipated that the College
will, within the next eighteen months, expand their present
computer

facility to a larger unit.

The equipment for the Departnent’s canputer center is
be
to delivered during the first week of May. We are now
appointing programmers. This will be a small laboratory,

consisting at

its

maximum

of

8—11

If this opportunity interests

your calling
Ext. 2H7.

my

staff members.
you,

I

would

secretary for an appointment at

appreciate
369-7900

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

'

�</text>
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                    <text>March 23 , 1967
Boo:

83376

New York Times Brooklyn
15%? Broadway
New York, New York

Dear Sir:
Your advertisement in the New York Times is of interest
The Department of chhiatry has recently embm'ked

to us.

a series of new pmgrans as part of the development of a
ounmnity mental health center. These prograns require delt
in evaluations of the treatment results and methods. We
are interested in appointing social scientists with different
badggmmds who may be able to contribute to these studies.
on

I

would appreciate receiving a cepy of your miculwn
and the opportmity to meet with you. If this is of
interest, please call my office at 369-7900 Ext. 2H8.

vitae

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf'dcp

�</text>
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                    <text>February 20 , 1967
Box Y2122

New York Times
1&amp;5? Broadway
New York, New York

Dear Sir:

of Psychiatry is undertaking a series of
evaantion programs and is developing a laboratory in computer
applications. A specific application is in the analysis of
EEG, and also in the use of rating scales in psycroprannaoology.
The Department

I read

your advertisement with

interest and I

pleased to review your curriculum vitae.

would be

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬂcp

�</text>
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                    <text>May

15, 1957

Box YGBRS
New
New

York Times
York, New York

Dear Sir:
The Department of Psychiatry of the New York Medical Cdlege
embaﬂcing on a series of extensive evaluatioh study programs
of the treatment methods in a oormmnity mental health center.
It is possible that your experience my be useful in such a
and I am writing to invite you to submit a curriculum
pviogram,

is

tag.

If

you care

afternoon at

to call, I

212 369—4900.

Trunk you

am

generally available in the

for your interest.‘
Sincerely yours ,
Max

MF:)&lt;:p

Fink,

M.D.

fessor of Psychiatry

�</text>
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                    <text>December 4, 1967
Box X8503

York Times

New
New

York, New York

Sir:

Dear

past year we have established a number of
research
clinical
programs focussed on understanding the
on brain function and behavior.
of
drug
treatment
impact
During the

Primary emphasis has been placed on patients in our Mental

health Clinic who are
psychotropic drugs.

now

receiving

a

variety of

new

parallel program, we are establishing an evaluation
of convulsive therapies utilizing some of the more advanced
quantitative techniques for estimating changes in brain
In a

function and behavior.

for
me

for

‘

;

In both these programs we are now considering
full time staff members.

If this opportunity interests you,

a copy

of your curriculum vitae

an appointment.

and

applications

wbuld you please send

call

my

office (369-7900)

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>.

a».

my

1"

u,—w&gt;‘-(w—"‘

October l0, I97l

.m.

w

m.-

"WW.

Z 3856
New York

Times

v.—(——-’-wv_——r.,

Dear Miss,

w...

n.

......

.7

m"-

.7

v

secretary of six years has left following
am seeking a competent secretary/
The Division is involved in the
receptionist.
typist/
development of new treatments for the mentally ill, with
special emphasis on drug abuse. The secretary acts as the
administrative assistant for a large staff, assuming authority
for expenditures and various services in my frequent absences.
My

her marriage, and

I

The work includes the maintenance of some records,

.»

"—n—uwnr—

allocating charges to various research funds, handling some
finances, and typing of reports. Most imperative, the position
requires someone with judgment to accept calls and allocate them
to the appropriate scientists.
if the position interests you, please call me at
2l2-

369 8488.

u'm—

‘K’F—W

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

l

l

l

l

l

E

�.—

.mww

J..."

m

.,

~mm

~‘m'rVn-r ~m‘mwV—mm

'vr-‘vsw

October l0, l97l
Z 6i22
New York

Times

Dear Miss,

Recenfly, my secrefary/ adminisfraflve assisfanf of
six years ieff affer her marriage, and am seeking a replacemenf.
The focus of our office is in The deveIOpmenf of new mefhods
fo freaf drug abuse and various ofher psychlafric problems.
i

secrefary is responsible for managing fhe office, felephone,
and considerable fyping of reporfs and pubiicaflons. There is
some lighf bookkeeping as if is necessary fo keep some
check on the expendlfures of various sclenfisfs in +he program,
and There are five fo eighf accounfs open af any Time.
The

The

office is at

if such
af 2i2-369 8488.

a

i02 Sfreef and

Fifth

Avenue.

posifion lnferesfs you, please call

me

“W...

W.

Sincerely yours,

y.

a,»

~;———-~r,1-..—,

-\

Max

Fink,

M.D.

Professor of Psychiafry

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                    <text>March 23, 1967
Box 88376

New

York Times Brooklyn

151;? Broadway

New

York,

New

York

DearSirz}
Your-

to us.

advertisement in the New York Times is of interest
of Parchiatzy has recently embarked

The Department

oneseries ofnewpmgmneaepar'tofthedevelopnentofa
cormunity mental

health center. These
require delt
in evaluations of the treatment results pmgmns
We
and methods.
are interested in appointing social scientists with different
badcgromds who may be able to contribtne to these studies.

I would appreciate reoeiVing a copy of your auricular:
and the opporttmity to meet with you. If this is of
interest, please call my office at 369-7900 Ext. 2168.

vitae

Sincerely yours

,,

Fink, M.D.
Professbr of Psychiatry

Max

MF:kp

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                    <text>\w‘lz’l‘T-VIWJ'

wanna.

"7w.

:II'J"

rim!)

:wv-—u»7mr'rrmmmm

“Wan-r

mum

«a:

0le

A.

v'

«Ix-urn:

wwwmmw

'

October 24, 1969

Editor

New
New

Dear

York Times

York,

New

York

Sir:

recent change in the Federal Government's position
regarding penalties for possession of marijuana is indeed
salutary. But your support of the Administration's change in
position was combined with support for another commission to
study marijuana - the bill suggested by Senator Moss and
Congressman Koch. Such a commission is unnecessary and
wasteful of funds; it can serve only to delay the research
efforts which already have been stimulated by the National
Institute of Mental Health, but which remain unfunded.
The

There have been many studies of the “marijuana problem” beginning with the Indian Commission in the last century up
to the extensive English Marijuana Commission Report of 1968.
Each commission finds we lack facts regarding the effects of
short term and long term use of cannabis. Is cannabis addictive?
Does it lead to use and addiction of opiates? Does cannabis
use lead to permanent brain damage?
In 1965,

NIMH

arranged a meeting of

stimulate proposals to

scientists to elicit

answer these questions. Many of
the recommendations have already been implemented and studies
are in progress. The recommendations included the development
and

of defined strains of cannabis with high content of some of
the presumed active components of cannabis, such as the
tetrahydrocannabinols. Projects to provide rapid assays for
the components of cannabis, and animal studies to determine
the long term toxic effects have been proposed. Studies
have been elicited to measure the effects of acute and chronic
smoking of cannabis on perception, mood, affect and driving.
Some proposals have been elicited to study the sociology of
cannabis use, including patterns of contageousness. Proposals
have not been limited to studies in the U.S., for scientists
have suggested investigations in areas like the Near East,
where cannabis use has been long standing and more socially
acceptable, to determine the incidence and severity of chronic
brain syndromes or other toxic effects.

�Editor,

New

York Times

-2~

October 24, 1969

We have recently been advised that many proposals may
not be funded because of limitations in the contract fonds
of NIH”. Considering the number of scientists NIMH has
been able to stimulate to look at the marijuana problem, the

need seems more for additional funds to allow scientists,
grantees and contractors of NIMH to carry out studies already
approved by expert committees which remain unfunded. Surely,
this is a more worthwhile approach than the allocation of
thousands or hundreds of thousands of dollars once again to
decide what should be studied.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
Birector, Division of Biological Psychiatry
New York ﬁedical College

MF:kp

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                    <text>February 16, 1991
Editor
Letters to the Editor
New York Times
Times Square, New York 10036
Sir:

Enclosed is a letter in response to the excellent OP-ED review by Oliver
Sacks of the state of our State Hospitals. It is submitted for your consideration for
publication.
.

The persistent failure of the State services to take advantage of our
knowledge is a reﬂection of a failure of leadership; the appointment by the
Governor of a non-physician as the head of the Office of Mental Health has not
been salutary. In this letter, I suggest only one method of helping the severe
mentally ill.
There is a lack of training and understanding of other therapies, as well,
including lithium therapy, new antidepressants, and clozapine. Many State Hospitals
have closed their medical wards, and are no longer able to care for the medical
needs of their patients.

I describe only one aspect of this failure to properly treat patients, and

seek public support for a public investigation of the state of our State Hospitals.
Thank you for your consideration.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry
Attending Psychiatrist
University Hospital

�February 16, 1991
To the Editor,

Oliver Sacks (New York Times, February 13, 1991) correctly complains
about the impact of the cuts in the State’s mental health budget on the care of our
severe mentally ill. We are reliving the ’Shame of the States’ of the 19405, but only

part is due to budget cuts. There

is also a failure to take advantage of advances in

mental health care, specifically the unavailability of electrconvulsive therapy for
patients in the State Hospitals.

Patients who require ECT from these hospitals have often been
transferred to the psychiatric unit at University Hospital for treatment, the only
public hospital in Suffolk County organized to give ECT. Other patients, from
Rockland Psychiatric Center where ECT is also not available, have also been sent
for treatment. The usefulness of ECT is well documented. Mrs. R, sustained in a
manic delirium for more than three years, is now well and at home after a course
of ECT. As is Mrs. W., a patient with a similar illness. Mr. K., is living in a halfway
house after more than a decade of continuous hospitalization with a catatonic
psychosis. Others were transferred with severe inanition, severe suicidal drive, and

malignant catatonia, and were successfully treated.

�The 1985 National Institutes of Health Consensus Conference on
Electroconvulsive Therapy concluded that "ECT is demonstrably effective for a
narrow range of psychiatric disorders in a limited number of diagnostic categories:
delusional and severe endogenous depression, and manic and certain schizophrenic
syndromes." It is precisely this range of severe mentally ill that populate our State

Hospitals.

In response to these evaluations, psychiatrists of both Great Britain
(1989) and the United States (1990) wrote guidelines for the use of ECT which

make the practice safe as well as effective. Its use has increased in the academic
and non-profit hospitals of the state, but it is available in only a few State
Hospitals. In Suffolk County, with three of the largest facilities for the mentally ill
in the state, ECT has only recently become available on a research basis in one

hospital, and even this usage is threatened by the proposed budgetary cuts.

The usual justification for failure to provide ECT is the lack of funds for
and adequate professional staff (mainly anesthesiologists), and for training. We
should not accept such explanations, since ECT is effective, humane, and even costeffective by reducing protracted hospitalization and the need for specialized nursing
care. The degradation of the State’s mental health services has already had tragic

consequences for our community. Rather than accept the Governor’s budget and
decrease services, we need a blue ribbon investigation of the state of our State
Hospitals to seek ways to use available treatments to help the mentally ill, of which
ECT is only one example.

Max Fink, M.D.

Attending Psychiatrist
University Hospital

�</text>
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                    <text>WWW—m;

_

....W~w.,.m, .w

.7

(W,

‘

._.

.

.

..-.,.__n_. my-

W

W

January

w...

1, 1986

”mm

my.

w“.

ww—u-

Editor- OP ED Page

New York Times
Times Square, New York 10036
Sir:

r-‘v-NWWW'WWWWVW

The opinion piece by Sergei Batrovin on December 31 was of special
interest as it described the administration of "sulfazine shocks a torturous type
of 'treatment', prohibited in the West, that puts the patient into coma, then causes
convulsions and many hours of unbearable pain."
——

w.

w-w—

wry?

sought to identify the compound 'sulfazine' and a search of various
sources elicited no clear identification. A search of the International
Pharmaceutical Abstracts found one citation to a sulfonamide derivative, and it is
unlikely that such a compound has the effects cited by the author.
I

would be grateful for a clarification. 1 am unaware of any substance that
produces the effects cited; nor am Iaware of any interdicted treatment which may
do so. The closest is the use of high doses of insulin for a treatment known as
insulin coma. Such a treatment was widely used and was replaced by
pharmacotherapy. I am not aware of any prohibition or prescription in any Western
country, nor am i aware of any instance of 'many hours of unbearable pain' in this
i

treatment.
Is

it possible that the author is exercising a high degree of hyperbole?

Thank you for any help in this interesting matter.
Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

um

mac

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                    <text>February 13 , 1967
Box XBQGH

New York Times
1&amp;57 Broadway
New York, New York

Sir,

Dear

The Depar'unent of Psychiatry

computer

is establishing a departmental

facility for scientific application especially in

analysis of neuroplyaiological signals , psychiatric rating
scales and biostatiatics. The center will begin with an IR!
1800 which is to be delivered in early May.

I read the advertisement with interest

to read

yomc resume.

and wwld be pleased

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MEN)

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                    <text>‘55“:

._

November 7, 1979
Hon. May w. Newburger
N.Y.S. Assembly

Albany,

New

York

Dear Ms. Newburger,

It was kind of you to remark on my award for my 25 years
of research into the mode of action if convulsive therapy. I hesitate to
presume on this kindness, but in the same mail, copies of legislation
being considered by the Assembly Ways 8 Means Committee came to my attention
which led to this ﬂatter. The proposed legislation ire amendments to the
mental hygiene law establishing standards for consent and disclosure for
the administration of psychosurgery and convulsive therapy (Amendments to
Sections 33.03).
The amendments for ECT are badly intentione-, seeking to
deprive the mentally ill of the State of this specifically effective and
safe form of treatment. The regulations propose to make more difficult
the task of administering treatments to voluntary hespdtdiized patients
and to render almost impossible to administer the treatment to involuntary
patients. The law is patterned after legislation in California, which has
led to the present traffic of patients from California going to Oregon
and New Mexico for treatment. This, of course, provides that only the
wealthy and self—insured are able to obtain this treatment. The legislation
is based on the erroneous belief that convulsive therapy is unsafe and
ineffective; the contrary being true, since all evidence finds that this
therapy is the most effective and the safest for endogenous depression.
In our 1976 survey, 5% of admissions to University centers in New York
City received this treatment (and only 1% of admissions in V.A. and
State facilities; clearly evidence of some reasoned use at University

settings.)

The amendment

for psychosurgery is also flawed. This

treatment is still an experimental one, and is at present only available
in Descarch setting where cases are reviewed by Institutional Review Boards.
The legislation adds additional onerous requirements for consent, making
the research even more difficult. At this time, the reports from Great
Britain suggest that this therapy has a usefulness with patients with severe
obsessive compulsive and phobic states. Thése data need verification. The
legislation will serve to reduce the studies, not encourage them.

�Hon. May

Newburger.........

November

7, 1979

..........

page

2

I hope that you will have an opportununity to review
these proposed laws and do what you can to prevent their adoption. If
there is any question regarding theta objections, I will be pleased to
meet with you in Great Neck to discuss it further.
Thank you

for your consideration.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

39

Arleigh

Great Neck,

Road

516 #66 sunu

New

York

�</text>
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11 December 1973

Laurence V. Faye,

Jr.,

M.D.

Assistant Chief Medical Director
for Acedmic Affairs

Veterans Administration
Department of Medicine and Surgery
810 Vermont Avenue, N.W.

Washington, D.C. 20420

Re:

112F3, 3 December 1973

Dear Dr. Faye:

for your invitation to participate in the V.A.
Orleans. I regret that I was unable to attend,
returning herewith the letter of authorization.

Thank you

meetings in
and

I

am

New

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

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18 January 1974

Shirlia

NINE Rm.

5600

Werner

9-101

Planet's

Lana

Rockvillo, Maryland 20852
Dear Ms. warmer:

I would like to indicate that Mr. Peter Irwin, my laboratory
supervisor. will attend tbs ECDEU mooring 1n Kny Bineaynn in May.
I unuld be grateful if you would 11:: him (at my Untvcrnity ad~
dress) a: a participant, and Iand him the reservation forms.
Thank you.

Sincurely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>May

16,

1971;

Leo Lange, M.D., M.R.C.P.

Central Middlesex Hospital
Park Royal
London

NW

England,

10

YRS

Dear Leo,

are prepared to work with Mrs. Rosselson early
regret. however, that you will not be visiting the
had
I
hoped to have the opportunity to go over our
for
States.
and
for
my
staff to meet you.
program,
in June. I

we

do

Please instruct Mrs. Rosselson to call me from
arrival. The various numbers are below.
I will suggest that she take a Long Island Limousine to the
community where I am at the time she calls-- either my home
in Great Neck, or the University at Stony Brook. We will make
the arrangements from there.
Kennedy Airport on her

My

best regards.
Sincerely yours,
Max

Tel:

Day: 516 hhh 2hh7 (University)
Eve: 516 751 h66h (if no answerQ)
516 166 Shhh

Fink,

M.D.

�</text>
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            <name>Source</name>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                <name>Text</name>
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                <elementTextContainer>
                  <elementText elementTextId="101195">
                    <text>Jammy 8,

114—13.

West

1961}

iéimitz Drive

Lafayetm. Indiana

Dear Mr.

Hickman

Ymrlettertom. Smé‘amhmhasbeenmfmd

to m beoam of yaw listed

Why.I

imam

in mmﬁxyaioloﬁcal

Wifymmdmllm

wouldbe
collect
s-suus
mssim
discuss
oppcammity
an
to
to
m
ﬁx:
yum
gut
bombs.

Sirmly yours ,
Max

ﬁnk,

Mater

Hleg

M.

D.

�</text>
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              <elementText elementTextId="7804">
                <text>Correspondence to: Nickander, Rodney C.</text>
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              <elementText elementTextId="7806">
                <text>mfp-05-00-018-1-025</text>
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              <elementText elementTextId="7807">
                <text>1964 </text>
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              <elementText elementTextId="7808">
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              <elementText elementTextId="7811">
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            <elementTextContainer>
              <elementText elementTextId="7812">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
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              <elementText elementTextId="7813">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="104354">
                    <text>May

2, 1991

Mrs. Robin Nicol
MECTA

Corporation

7015 SW McEwan Road
Lake Oswego, OR 97035
Dear Robin,

It

was a

36

Spring Hollow Road

to work with you, Gorham, and your
pleasure
CME course in New York. Despite the
unpleasantness of the intrusions, the students seemed to get
much from the course. John Schwartz was sufficiently pleased
to call to say that he would like to undertake another
course this Fall, and perhaps establish an 'Advanced Course'
as well.
I would like to return the modified MECTA SR-l which
you kindly sent us last year. It is in excellent shape and
could well be returned to your inventory. Would you send me
the appropriate carton and packing materials so that I can
return it in good form?
Again, send the material to me by UPS or other
freight handler to:

associates at the

My

St. James,
regards to all.

New

York 11780

Sincerely yours,
Fink, M.D.
Executive Director

Max

�</text>
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      <elementSet elementSetId="1">
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          <element elementId="50">
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                <text>Correspondence to: Nicol, Robin</text>
              </elementText>
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          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="66415">
                <text>Text</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="66416">
                <text>mfp-05-00-032-3-098</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="66417">
                <text>1991 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="66418">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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          </element>
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              <elementText elementTextId="66419">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="66420">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="66421">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="66422">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="66423">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            </elementTextContainer>
          </element>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="93966">
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          <element elementId="37">
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              <elementText elementTextId="100527">
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                <name>Text</name>
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                  <elementText elementTextId="103171">
                    <text>November

7,

1969

J. H. H. Nieboer
Accts. Department
Excerpta Iedica Foundation
119-123 Herengracht

Mr.

Amsterdam, The Netherlands
Dear Mr. Nieboer:
I have looked into the invoice that you requested
in your letter of October 30. Please be advised that
the above invoice was paidoon February 20, 1969, our
check #29490. The check was in the amount of $1,315 and
covered items in the amount of $1180, $20 and $115.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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            <element elementId="50">
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          <element elementId="50">
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              <elementText elementTextId="41574">
                <text>Correspondence to: Nieber, J.H.H.</text>
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          </element>
          <element elementId="51">
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            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="41578">
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                    <text>November 18, 1972

Division of Research Grants

NIH

Bethesda, Maryland

20014

Gentlemen:
We

would appreciate receiving 3 copies of the NIH

”Grants for Research Projects: Policy Statement", DHEW publication
(NIH) 72—8, dated July 1, 1972, for distribution to the principal
investigators in our programs.
Thank you.

Sincerely yours,
Fink
Executive Director

Max

%

E

mf/

�</text>
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                    <text>November 6, 1972

Contracting Officer, NIMH
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Sir:
We

have seen an informal notice
1 pharmacology

bids for the study of pgase

antagonists, Notice
We

SS-NDA—73—S.

would appreciate a copy of

have been interested in the

clinical

that

NIMH

trials of

is requesting

novel narcotic

this Notice. For

some

years

pharmacology of narcotic
antagonists, and believe that some of the methods we have developed
using EEG quantification may be applicable.

we

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>January 27, 1965

WM-WBS-OS
To:

mm:

mm
m,
Mam

PM).

available an additional
madman
m
$700fcmbodcsorjmmmbom1fofﬁnm~

1. The

farmpermd
mybnapproprnummmmmdsubudttow
twining

(”18%“)

2/1/65-8/1/68. Plusemkesuchmqmtsas
‘

comm. m.31m.

2.

Polladngymmsuggestim,nr.metthasautho¢~

iudﬁmmasaimtofhomlﬂuﬁmmfeldmd

m.rﬂllortowmumpmmassomas
3.

my:
m

co:

mmmummmmwmt.
Ihawwzitmer.Marﬁnmpmtpminghis

musk.

W

�</text>
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                    <text>h/18/62

Biographical Sketch

arriving late at a Joint meeting of the departments
of psychiatry and neurology at a leading New York hospital,
0n

Fink

tells

of being Jokingly asked by the chairman on
what side of the "professional" aisle he would take his
Max

seat that night. The two aspects of his interest and training in neurology and psychiatry are reflected in his professional career which has been devoted to research studies
into the neurophysiological and psychological aspects of
psychiatric treatments at Hillside Hospital. While develop—
ing the programs of the Department of Experimental Psychiatry,
Dr. Fink was a practitioner in the North Shore area, and it
was during this period that he took an active part in the
activities of the N.P. Society. In 1959-60, he was president
of the Society -- thgryear the Society saw the founding of
the Newsletter and a re—organization of the committee system.
Eaziaggiperience answering the tdsphone and as an
observer of the excitements of his father's busy medical

practice aroused his interest in medicine at

an

early age.

pro-medical student on the Heights campus of New York
University, he undertook his first research study as part
of the biology honors program -- an analysis of the "periodicity
in mitotic behavior of the neural tube of the embryonic
As a

chick". While he achieved many scholastic honors as an
undergraduate, none are so prized as his election to the
honorary political science society, Alpha Pi - as the single

�-2pro-medical candidate in a class of pre~1aw candidates!
Medical education at Bellevue during the war years and
a

rotating internship set the stage for military service.

"interest" in neurology

sent to the
School of Military Neuropsychiatry and‘a career in psychiatry.
With separation from the service, and feeling that there was
more to the world than his stateside experiences allowed, he
shipped out as surgeon, first with the Grace Line to the west
coast of South America and then with the American Export Lines
to the Mediterranean. Coming ashore in New York from a cruise,
he was introduced to the young daughter of passenger friends
and soon after, began the courtship with Martha which led to
marriage in 19h9.
After the cruising sojourn, training continued in
Montefiore, Bellenue and Hillside Hospitals. Concurrent
training at William Alanson White Institute led to his receiving their Certificate for Physicians in 1953. It was
at Bellevue, while a student with Morris B. Bender, that he
launched his research career. Stimulated by Dr. Bender's
pioneering perceptual studies, his first interest was in
simultaneous tactile stimulation tests as reflections of
brain dysfunction. Studies of carotid angrcgraphy, psycholinguistics, electroencephalography and psychological tests
followed rapidly as aspects of behavior under conditions of
altered brain function. These interests became the foci of
Because of an

he was

wL~.nAuﬁA-m~

�-3the programs in convulsive and drug therapies at Hillside
which have occupied his full time interest since 1958.
This work has been honored by awards of the

Electro-

shock Research Association and the Society of Biological

Psychiatry, and recently, by appointment to the National

Institute of

Mental Health Connittee

on

Clinical

Drug

is also consultant to the Director of the
Division of Mental Diseases of Missouri, and is participating

Evaluation.

He

in developing the programs of the new Missouri Institute of

Psychiatry.
Tennis and skiing are the principal recreational
interests of the Fink family. Last August the family

Joined Jonathan in camp where Max was the camp physician ~spending most of his time on the courts and water skiing.

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                    <text>Amt a,

For: Animal Report lssau-sn

1963

Institute of Psychiatry

Prom: Hex Fink, H. 1)., Director. Missouri

Mention of the Louis B. Kohler
me first year has largely

Building in October, 1963

Institute
mmmormmmmormmm
of Wm.
to
laboratories, staffing,
“me

the wards and the

been devoted

equipping
md developing prom.

Wesley, minded Nemhyeiology,
.endClinioelPayoholosvaubeeneppointeo. AeofJulyl,19&amp;3
the full time staff of the Institute is twmtyufour 8 scientists;
11 wMeme; 2 libreriem and 3 mmiee).
nurse Primipel Scientists, in

.

C

w

W
M
illxuesee ere ambushed.
e

“me first
was an evaluation of the treatment poseibilitiee
of sohimptuenio patients hospitalized a to 8 years. In
in e
this «elation. the physiological and sociological fame of the

1115mm.

trzinmgzinthe-Wmmmityergdmte
we opportrtytotzeetegmupo Wally
Nurserm were
~epetimts. Ameriuonmmminteimdinsn

«new turd and an evaluation of this form of thempy was muted.
The

Institute established a research Water Center.

Lehomtow em a

Hummloy laboratory by July.

Neurophysiology

Ineddltimtoswmmhipofﬂuubmry.ﬁnsteﬂofthe

‘Imtitutejessmd the mspmsibility for the Psychiatric
.

Residmmy

mm the cooperation

Mditloml funds for research were obtained
of the Paydxiatrlo Research Pmmdation of Missouri.

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                    <text>December 28, 1968
Dear Reg.
1

an,plaased that 133 will canparate with ch¢ Intatnatianal
am writing to suggest some specific details that
the daaonatratians mare mental.

Congress, and I

would make

1. Tha programs

the exhibteiun.

will raquire

a fsw days of dabugging befara

for the éamonscratton shgald be available
a: least one «ugh bafora the axhibitsan, anﬁ beak the axhihitien hall
managers. the shipgors anﬁ 13% abould bu aakaﬂ co agrxe tﬁat the
exhibiclaa actually will be for the period Septamber 6/7 to 20.
2.

Va

The spngm

will plan to damoncttacc

from cages or from a

liva subject.

aha kinds

cf analyaas

um

dc,

For tapas, we will require a 1/2 inch SPBOO Ampux FM
recorder. To damnnatrate the plat pregrama, we use a Tektranix
osailloseope with a long pcxnistancc scruen cad a Palarmid camara.

is

EEG,

In damonstrate that what

parhapa an

EEG

19 caning ﬁrom the tap&amp;
channel from Grams wanlé ha uneﬂul.

for a liva demcnatration. thure will have ta bu
an EEG (Wt pretax Grass) and a band»pass filtar, and a chhhait
would be moat usafal. we vauld like ta show the dfﬁacts of
pentothal and this will allaw us to ﬁamonatrata our mathematical
model at the pantothal response. It may bu less useful in vnlunteers

than a demonstration of a hallucinogtn or a dimpla alarttng experiment.
but wn will tailor tha axperimcntal details to tha setting anﬁ the
ether axperimenta 1n the program.
My

best regarﬁs.
Sincarely yours.
Fink, M.D.
Profnsaor af Psychiatry

Max

�</text>
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                    <text>December 11, 1968
TO

WHOM

IT

MAY

CONCERH:

Mr. Staniey R011 was empioyed as a pregrammer on
January 15. 1968, to participate in our research program
app1ying digitai computer methods to c1inica1 psychiatry.
a

Mr. R011 devoted the majority of his time to interfacing
217 disp1ay scope to the IBM 360/40 and programming a

CBC

behaviorai rating sca1e using this device. During the initiai
months we had some difficuities with hardware but as these
were so1ved the programs were comp1eted.
Mr. R011

resigned effective December 15. 1968.
Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                  <elementText elementTextId="102767">
                    <text>November
T0

won

IT

This

currently

3,

1968

MAY CONCERN:

is to certify that Professor Jiri
empioyed by as as

Roubicek

is

Visiting Research Professor

in the Department of Psychiatry,

New

York Medical

Coliege.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>April 5,

~
._

wwgmwl.‘

ﬂaw-r”

)Qﬁdmrrrm

WJW'TfZwnr,'-&gt;r.’v'.'|fy‘.-7F~,~r

I;
F.

E

E

g
E‘

F

g

i
i
E
E

E

3
5;

1969

Dear Leo,

I have just read your review of the clinical status of
psychotherapeutic drugs in Clinical Pharmncolqu and Tﬂerapeutiua with
great interest and wish to congratulate you on writing an aminently
readabla and useful report. I would apptactate a reprint whan thesa
are available, but will probably gore: the report for the students, since
most of the opiniona are similar to thase which I hava preaaated and
hold.
Taste nra a few cmmmenta that I.would like to ahara
with you. Recently, with regard to the'anti~anxiety druga, um
reviewnd our clinical recordﬁ and found that tha results observed
for chlozdinzapoxide were vary gaod during the early waaks of treatment,
but the response became prograasively less in time. we examined the
data for the possible development of tolerance ané in some reeant cases
we have athieved better results by interrupting treatment at frequent
intervals. In our studiaa of high acne tybamate in tha treatment of
opiate addiction, we were aatonlshed at the rapid rate which the
patients dgveloped tolerance to the aeprasaﬁve an&lt;§sedat1ng effects
of the dosages we uaad ( ti 12 Gms.

)

In the notes on tha traatment of psychosis, why was no
mention made of the possibla utility of long~acc1ng fluphanazine ?
Your choice of thiariduaina as can of the drugs to be
included in one' a armamentariua shows how brave ycu reall.y are, for the
EKG changes which vs found so prominant have haen sufficient t0 deter
me from racommending it for just each purposes.

Again,

my

congratulations on a reviaw well dona.
Sincerely yours,
Max

Fink,

M.D

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                    <text>Hay 27, 1969

Dear Dick,

It was nice to receive your letter and it aoonda as if
achieved
less than you had hoped for but more than most on a
you
European visit. I had the occasion to visit Alex Koreans: in Rome
last week and hie experiences match your own.
I called Dr. Wbrtis, so you requested, for we had not
heard about your report. The volume is no longer being published,

instead the Society is issuing a new journal, Biological Psychiatry,
is to come out six times a year. The first ieaoe is now
in distribution (it was exhibited in Miami early in May). He said
that the paper has been accepted by one reviewer ("high marks") but

which

the second has not yet returned the menuaeoript.
I am sorry
that we are caught in a bind, in the issuing of a new journal. And
Joe wortia is not the most efficient of editors. I would suggest
we wait another month; and if you do not hear from him by lune 15,
I would write to him (or, better, call) asking the status again;
and if he gives you the usual doublewtalk, perhaps you should
consider publishing it elsewhere.

is foousoed

more on neloxone (how long
by increasing the
single oral dosage) and on methadone (how long does the usual
daily dose of methadone protect a patient against injected heroin).
and less on cyclexooine, although we have completed one essay on the
We are also trying
typology of patients who do well on cycleaocine.
to extend the duration of neloxone by embedding it in a plastic
polymer, like Sileetic, in the hope of achieving a 30 to 60 day treat~
Our program

can we extend the

antagonistic actions

meat.

’1 attended a meeting on peyohotropic drugs in Liege and met
a group of pharmacologist/ohemists from Sweden headed by Foxe of
Karolineka. They are doing fine work and if you do not know their
reports, perhaps you would look them up.
Keep up

the good work

!

My

beet regarde.
Sincerely yours.

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                    <text>Msy

25, 1969

Dear Alex,
By now you should have received my note shout my
visit to
Athens and Bro. Mites and Stefania. The remainder of my trip was
as interesting, if not meta so, than tho first part. The meetings in
Liege were exoellent, with some presentations by biochemists and
pharmacologists from scsndioovis that were relevsny to our interests.
Much of the emphasis was on dopamine and noradrenalin, however,
,and in one discussion, when I asked about the role of acetylcholino.
I was told that it was indeed important but that the absence of a

suitable biochemical assay bed limited the studios to the oeurohumors
that could be studied easily. (Thio was also stated by Dr. Eunnoy of

EIHH who

spoke

at our College this post week.)

I so still interested, however, and so taking the opportunity
to enclose coma reprints of my studies. It seams to me that the
convulsive therapy is the most specific and the best treatment of
severe depressions in men; and that the study of its central effects
should contribute so much or more to our understanding of deprassion‘
as the study of other oeurohuoors affected by imipramino and MAO inhibitors.
In my earlier review I was impressed with sostylcholine, but this
may have boon related as much to the available studios so to any
relevant theory. The same study should be applied to the other
ooutohumors, especially oorepinsphrins and dopamine.
are treating ospreseive patients with induced convulsions,
and bilateral elect rode placements. There are
significant differences in EEG and in memory effects of the two types
of treatment, and while those may be principally matters of degree rather
than kind, it does.provide tho oppoortunity to study two éiffetent
CS? psttsrns. we should be able to obtain CS? before and during the
treatuont process.
We

competing

unilateral

‘

.

Have a good time in Greece. It is possible, though remote.
that I may be back there in August. so pleaoo send me your Greek address.
If not, perhaps you will write when you return to Chicago sad we can

discuss thui further.
Agsin,

my

thaoks for your

»

hospitality.
Sincerely yours,
Max

Fink, M.D.

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                    <text>g

.- “" .
‘

v-

rum-w.vawmway—we'rwmqumv-Wrw

"“‘ “4."‘ '

“

.

V

,--&gt;,

‘

,

”H

"'17
r .,.

V'WWWL'WW‘FW“

23. 1969

Dear Milt,

May

Tha Program Committee

of the

1970 CIR? met

in

Roma

on

6/7 and discussed the suggestions for symposia and lectures as

presented by different delegates and members. All the suggestions
of

made by myself and the Czecha were turned down by the majority
Tha suggestion of a symposium on EEG models in
the Committee
drug evaluation was also rejectad, and no EEG program accepted.
3

The principal foci will be on neurohumors (including
alleged naurohumnrs), lithium and amphetamine addiction.
we

will

U.8.

Y

Thank you once again for considering my suggestionw~ but
have to find ancther forum. perhaps another society in the
my

E

wr-P“

'

May

P

vwvu—v—ywv—wwrw.wnun_

__

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

m!

vu'A‘AV‘JWV-iwr«mum—m..-

‘

v

‘

-

Mm: magnum-'—

�</text>
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                    <text>May

18, 1969

Dear Carl,

have no objection to the circulation to other ECDEU
invastigatoro of the demography data of our studies. Some weeks ago.
however, in anticipation of this meeting, I asked Dr. Simeon to
update the recorda of all our studies, and these revised forms were
cant to Dr. Guy. we would prefer to have the corrected listing
presented, if at all possible.
We

1

look forward to seeing you in June.

Sincerely yours,

Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>August 27 , 1969

TOWITWCORW:
Fonmingtherequestofl‘b. J.

W.

StanciloftheBoard

of Veterans Appeals to Dean J. P. Eagle, Nov York Medical College,
the record of T. B. anday, C-‘W62879 was received for review
on 8/21/69. The record consists of depositions, military record
and

letters to

w:

and

has

V.A. claims

offices.

at the age of 30.
visual acuity defect, correctable to 20/1“).
Ming military service training, he claims to have suffered
a. fall on 5122/“, breddng his glasses, He was di
in June, 19m, A pension was wood, which on review 19“?
it»

Exaninat on showed

Monday enlis- ted 3/11/Im
a.

wasdeenedtobeinemcr, andmscirded,asthedisability
not service-mooted.

was viewed as

Claim: Progressive visual defect, aggravated by military
service, and yielding a state now of virtual "blindness".

ions: Mpsyohistricquestions misedbytimmﬁner,

Wmﬁmbasisofthemcord,mz

to

and

1. Does the veteran have a functional visual defect?
Diagnosis?

g3.

Data:

status.

Be

probable that it advanced during military
itservice
(19%)?

5.

Is

u.

Istheoowseofthedisozﬁermthanwmld
beacpected?

The record

is

is alleged to

have managed a fwnily type
Only one

sparse with regard to psychiatric

have completed hiya school; and

retail store prior to service.

psychiatric emiration

was found, dated

to

3/25/69, from the V.A. Center, Mountain Hone. Johnson City,
Tennessee: "...except for the possibility of fmctional
visual defect, he shows no recognizable evidence of mumsis

at this time."

�-2The depositions

present a

mixed

picture - loyal friends

citizens alleging severe interfermce with vision since
191m; entertainers finding a dissociation between his behavior
(in store, street, daily affairs) and the mninations, which

and

severe

show

bilateral acuity loss.

inion. The record presents no evidence for a hysterical ’
dissoEEEE’
state, and lends itself to the interpretation
that acting-out ("malingering") for secondary gain is likely.
of a detailed psychiatric exanination which
such
supports
a diagnosis takes the following opinions temnus.
The absence

l. 'Iheclaimantmyhaveafmctionaldisorder20
wiﬂxcm:

its rapid onset in

lean and persistence for
years
outward evidence of organic progressim are supporting evidence.
2. A psychiatric diagnosis is not possible on this
record; altlwugm psychosis, as camrticnnlly defined, is
mlikely. The absmce of evidence of neurosis, makes malingerdng
as well as an organic state more likely.

psychiatric state could have been precipitated
daring military service. 'Ihe very natme of the stresses of
service, the unconscious wishes to escape, the acceptance by
society of physical disorder as justification for military failure,
3.

A

andcoupensaticnlmsermanceandsupportthedevelcpmntof
corzversim pimmena and malingering. In addition, the
culture franwhioh Mr. Norway derives, may invest such in a
credible, aggressive military service; and Mr. Monday's apparent
"failure" could be excised, if it were mdically derived.

detemination of the presence of a conversion reaction or
"nialjngering" shmld be made by a psychiatric eminatim dedicated
to such a determination. The record by P. A. Vesey (3—25-69) is
béirtcaxplete for this determination, and a more detailed study may
A

advisable.
1+.

Thecomsecfthedisorderismtmusualfor

conversion reactions or mslingsring. , occurring in situations
where secondary gains are derived fron the conﬁrmation of the
disorder ~ as is possible in this instance.

I an Professor of Psychiatry,

New

York Medical College,

York University College of Medicine, 19%;
mediated from the
licensed to practice medicine in New York and Missouri; and a
diplomats in neurology and psychiatry of the American Board of
New

Psychiatry and Neurology.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

a as;

�</text>
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                    <text>"In—1m m.

2“,." . .,.»...m.\.....Mum-4...”....

-,,.-

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v.1,

r

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March

l7, l970

--

wvrw-w-z-L

To Whom

it

'»—w-

i
,.

.mg-wr—mﬂ.

am

May

Concern:

writing this letter in support of the application of

Mr. Peter lrwln for admission to medical school. i heartily
recommend his admission, believing that he would make a knowl»

edgeable contribution

m

sum-guw.

‘n-JN

e

'

”WWW

“Wu

Nam

hava known Mr. lrwin since January l968 when he Joined
my staff as a research fellow in lieu of military duty. He is
a registered conscientious objector. During the past 26 months
he has prograsslvely assumed greater and greater responsibility
in my research programs, evaluating psychoactive drugs in normal
voluntears. He has exhibited abllltias in interviewing and assessing
drug effects. both gross and subtle; he has developed a facility
in reading and analyzing the human electroencephalogram for
research purposes; he is capable of handling electronic equipment, including an lBM l800 computer; and most importantly, has
l

an

szwmwnwv

to medical science.

ability to relate to
He

is

a

members

of

«um—tr.”

staff.

personable young man, friendly and well liked.

At

has assumed responsibility
assertive.
with
and
good Judgment and for
sxoacitas
responsibility
gladly
confidential matters, with discretion.
times he is brash and

«an.

my

He

His uncle, Professor Samuel lrwin, of the University of
is a well known research sciantlst in psychopharmacoiogy.
His uncle's stimulation led to his working in this laboratory and
he has developed an enthusiasm for psychiatric research which is
commendable and which i have encouraged.
Oregon,

Wrpr'm—W.Y

pleased to racommand his admission for medical training
despite the apparent lack of basic science interest during his
early college career.
i

ra—u-

2

am

Sincerely yours,
Wﬁ'wi'l'm‘w,mﬂ_lwlw

Max

Fink, M.D.

Professor of Psychiatry
Mszp
.

..

�</text>
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                    <text>WW‘Z’

:v-unv m .mrw-ww’.

"K‘Jru'n'.

mmquswnmW‘s—w.«a wr ywlm.""x’0wvn :
I ~

arm

“aux-.-

».-

nu ma: Iw-B'WF&gt;IS:- m. 1" V

-

.uuv.» vum-m-uuan

-

yws—u—w—v-wwww(.mqanryump-u;

(us-W,

v
r—‘Vy'rmx14‘r'nvvm‘w"~»~uw:w~.wn‘mxﬂ]uv""r“l.wvn‘

June 29, 1970
T0

WHOM

IT

MAY CONCERN:

psychiatric assistant

Mr. Robert Sharp was employed as a

in the drug addiction research program of this Department of
Psychiatry from October 1967 to April 1970.

During this period he assisted us in interviewing patients
with opiate dependence; supervised other assistants; participated
in group therapy sessions; and coordinated ward activity programs.
In these efforts he was diligent and reliable. He assumed
responsibility and carried it out.
he

left

us for personal reasons, wanting to be with family
I regretted his leaving, indicating that
California.
in
could have his position back as long as it was unfilled.
He

members

I

am

pleased to

recommend him

for

a

similar position.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>September 9, 1971

It

To Whom

May

Concern:
RE:

Maureen Garcia

Mrs. Maureen Garcia has been working for me as an EEG
Technician since October 19. 1970. She received her training

at

New

York

University.

is a dedicated worker with a serious interest in providing
artifact free records. She is fuiiy trained, and I believe, can
make significant contributions to the A.S.E.T.
She

Sincereiy yours,
Max

MF/rs

Fink,

M.D.

�</text>
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                    <text>January 6,'1971

TO Wﬂﬂﬁ

IT ﬁAX COﬁCERﬁ:

Doctors Professor aha: Dornbush Ph.D. and ProfessorﬂewJanYork
Volavka, H.D. are mambera of the Department of Psychiatry,under an
ﬁadical College and are carrying out studios in cahhabis
Grant 18172 and Contract “5% él~70~93 (Studies of Marijuana Users
in Groece).
Under the terms of those grants, Doctors Dornbush and
Volavka are carrying with them marijuana oravidcd by the Rational
not exceeding 500 grams
Institute of ﬁental Realth in an amount
which
an import document has
and 200 grams marijuana ylacebo, for
of
Greece.
been obtained {rem the government
thom sup—
their return, oitner or both may bring with
invcs~
by
our
forms
provided
plies of hashiah or cannabio in other
attached.
tigators in Greece. An import permit for this is
On

This inboratory operates unéor the appropriate regulations
of the United States Bureau of Narcotics and DongcrOus Drugs and the
Sttte of ﬂow York, and copies of these documents are attached.
In the evcnt that any questions arise regarding the truns~
or from
for of those materials from the United States to Greece
undersigned
the
Grooce to tho United States, we urns you to contact
Na~
at 212c369-8‘83 or 516-666—56‘k or Dr. Robert Peterson at the

tional Institute of ﬁontol Heclth (301w443w4663).
In the event that problems aria. in Graces,

we urge you
of
Biological
to contact Professor Constantine Miras, Protcnuor
Costa: Steand
Profossor
Chemistry, Univuroity of Athens (771«155)
(6&amp;3—2025).
Athens
of
fania, Professor of Psychiatry, University

�Thin projact has been brought to the attention of the
American Ambassador to Greoce, Hr. Charles Kennedy and should any
questions arise that should require his intervention, 1 would appreciate your contacting him.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

ﬂY:1g
Enc.

�</text>
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                    <text>January 6,

1972

Accountant's General Section
Reckitt &amp; Colman
Household Division
Danaon Lane

Hull, England
Dear

Sir:

chloride.

We

We

have received the supply of diprenorphine hydrohave not received a bill regarding charges for

this shipment. It

material, supplied

was my impression that this was research
by Dr. G. Blane for research purposes.

Should there be a charge, we will be glad to
pay
Please submit a specific charge in dollar equivalent.

Sincerely yours,
Max

Fink,

m.

Professor of Psychiatry

H!:ig

cci

Dr. G. Blane

it.

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                    <text>”W

April 10,

£8:

To when

It

Hay

1972

Robert Sharoff. 3.3.

Concern:

I have known Dr. Robert Sharoff since 19ﬁ6 ~ first as a
co~worker in substance abuse, and lately as a member of the faculty.
At the time I joined his staff, I kaew very little about opiate abuse,
its management or its psychopathology. I found him erudite and willing to teach, not only me, but the residents.

excellent were leader, a fine and patient teacher.
a methodical and careful worker. He is well liked by the staff,

and
and the

he

is

an

patients.

pleased to recommend him for a position of psychiatric
teaching and treatment, and aéminiatrative clinical leadership.

I

am

Sincerely yours,

Professor of Psychiatry
:Eﬁig
cc:

Robert Sharoff, M.D.

�</text>
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                    <text>April

10.. 1967

Br. [34131: News:
103 East 83th

Haw

York,

Strut

Nu York 1.0028

mm Roma:

Hummuplmwhmympmicipatainmmic
.mmtmammmwmamtmmn
Imuléappnciatnywr
affactimwwabmt Jam 1,1967.
tho
389-»7900'm.

WW1“
Wisdom.

tom-mg:
.-

228

callingm.

Wimmmthudmtmmmmm,
plcmgctmtmmhwithm.mfwnwianmntymwith

mmmmmammmmdmm.
Whammmmmammwamuimof

Mfmtfmafmmtfmnmicwicﬁmmdyw
-smmnummtm.nicmm¢kmnm1opmgm

Wupactsofﬂdsm.

'

wammmmmtmmm.
Sincerely yam,

PM

Hm Pink, 3.1%

Macaw of
I

Wakp
cm

1hr.

3mm
Shaun!!!

mm
132-.

‘

�</text>
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Local 1199 News
709 Eighth Avenue
New York, New York 10036

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October 7, 1969

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Dear Mr. North:
I regrot that it is outside of our usual policies to
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Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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Mr. Daniel North
Local 1199 News
709 Eighth Avonue
New York, New York 10036

0ctobcr 7,

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Dear Mr. North:
I regret that it is outside of our usual policies to
allow photographs of the treatment programs of this Department.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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war..—

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                    <text>July 8, 1993
G. Northoff, M.D., Ph.D.

Zentrum der Psychiatrie

Klinikum der Johann Wolfgang Goethe-Universitat
Heinrich-Hofmann—Str. 10
6000 Frankfurt am Main 71, Germany

Dear Dr. Northoff,
In response to your letter of June 17: We occasionally appoint Fellows for
post-residency training and research. These appointments are usually made from our own
graduates, but about half the positions are given to trainees from other programs. For
those interested in clinical research, we require the satisfactory completion of the ECFMG
examination, and a visa which will permit the candidate's stay in the US. This is usually
the J-1 Visa which is issued on the request of the University.
A letter of application, accompanied by a copy of your curriculum vitae,
and a statement of your ECFMG status (Passed, date; or, scheduled examination date) will
start the application process. The letter should indicate the date on which you anticipate a
willingness to begin training, the duration of your willingness to take such training, and
your social status (married or single) and dependents.
We are actively involved in research in catatonia. These are under the
supervision of my associate, Dr. Andrew Francis. Our prospective study of incidence and
our rating scale developments are being written for submission for publication this
summer. We are continuing these studies and are developing a prospective study of the
biology of catatonia. We hope to have a protocol completed and submitted for funding by
the early fall.
Thank you again for your interest. Let me know how we can be of ﬁirther
help.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>January

12

, 1967

Miss Ruth Norton
York Medical College
Flower and Fifth Avenue Hospitals
Fifth Avenue at 106th Street
New York, New York 10029

New

Dear Miss Norton:
The goal

of the exhibit

is to state that:

l.

Teclmiques

2.

These changes bear distinct relationships

the

exist for measuring changes in

human EEG.

to the behavior of psychiatric patients.
There are few quantifiable measures in psychiatry which
are related to behavior. Many efforts have been made to
study blood pressure response, heart rate, speech and to
relate these to mental states of patients. Each of these
methods have been difficult, partly because the measures
themselves were difficult to quantify and the relationships to behavior were :iélusive.
Brain function, however, is mirrored by the
changes in brain function appear so be directly

EEG

and

related
tobehavior. Forexample, ﬁtteEmshavsadungemtm
direction of a slowing of the frequencies this is almost
always accompanied by relaxation, a decrease in anxiety and
tension and an improvement in psychotic thinking. If, on the
other hand, the EEG shows changes in another direction (called
-,

desyncrmonization) this is often associated. with increased
psychotic activity, increased anxiety and a clinical worsening.
In

this demonstration we

would

like to exhibit:

l.

The

2.

Data from studies showing the relation of
changes of EEG: to changes of behavior.

'

actual quantifying measurement of the

EEK-3.

�Miss Norton

-2-

January 12, 1967

_

WeMpetodothisbyanactualdemmsmtimofanmulysis,

an exhibition by charts of the. data of studies , presentation
of documents describing previous studies and by having questions
answered by my associates and myself.
‘

Attached are two papers that summarize (unfortunately in

scientific

law) the point of view that

I

grateful for your help.

present.

would be

we would

Sincerely yams,
Fink, M.D.
Professor of Psychiatry

Mm:

like to

�</text>
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                    <text>w

.u -"\v“‘~av WM»1¥F'W‘M-kw‘~7'v"v

w

.a

ivxwa-www ~17“

.

p-wy-wwum

Maw-”Vi!7.

January 14, 1971

Noahpitz“ ‘za

Mr. Joe

Hillcrest Childrens Center
1325 W. Street, N.W.
Washington, D.C. 20009
Dear Joe,
many

felt

It

was an unusual pleasure to meet once again, after
years. Mel and Blanche have spoken so often of you,
the gap in time was momentary.
as

if

these

that I

We have had little opportunity to apply our ideas to the study
of childhood disorders. The observations that stimulant drugs improve
the behavior of hyperactive children provides the basis for a
speculation in these children that is testable.

(1) The stimulants used, dextroamphetamine and
methylphenidate, alter brain function in a way that is reflected
in the EEG as increased fast activity, increased Inriability of
frequencies and decreased amplitudes.
(2) Quring childhood and adolescence, systematic
”developmental" changes in brain function occur, and these are
reflected in the EEG as progressive amplitude decrease, increased
regularity of rhythms (decreased variability) and increasing faster
frequencies, from the usual 4~6 cps of the young child to 6~8 cps
of the pre~adolescent to 9—11 cps of the adult.

it be that a characteristic of hyperactive
record more immature than their age, and both
successful treatment, a change is induced toward maturation (and
in unsuccessful treatment, the change fails to occur)?
(3)

children is

to

an

Could
EEG

enclosed summary of our
are enclosed.

The
ECT
My

EEG

theory and an earlier application

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

MF:kt

�</text>
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                    <text>weir"
FJYN w... . m..-y-_.m.m"W.—mumw-uI-w'rm
,

,

_

WW

'1-

October 7, 1970
Docteur Nourricier
Laboratorres Delagrange

Madame 1e

la Tour Manbourg
France

39 Blvd. de

Paris

E

—

WW‘WW""“

,

Dear Dr.

Nourricier:

For many years I have been interested in the

analysis
psychoactive drugs. Earlier this year, sulpiride was
brought to my attention as a compound with clinical psychotrOpic
activity but without the usual pharmacologic profiles. At the
GIMP in Prague, this interesting discrepancy was confirmed in
discussions with Professor P. Simon.

of

&lt;

'I'8

EEG

new

—~c—--.-v&lt;v

request, he has sent me some data from his files,
suggesting that I write to you for a more complete record of
investigational data. I am interested in the basic pharmacology
data and available clinical data as usually supplied to
investigators prior to clinical studies. I am writing to ask if
such information may be made available to me, as the basis perhaps
At my

«awn—«mm-w—p—

WW-..—

vap

w.

._

_.

of a clinical or

EEG

profile study.

To provide a reasonable background for this request, I am
enclosing a copy of my 1969 BBC review which is the basis for
our studies.
Many

thanks for your consideration of

this request.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

’

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                    <text>December 19t3, 1972
Anthony Novels, M.D..
Biological ResearCh Section.

Clinical Research Branch,

Rational Institute of Mental Health,
5600 Fishers Lane,
Rookville, Maryland 20852.
Dear Doctor Howels,

I am pleased to enclose a number of reports, both
publiahad and in press. which have been accomplished
under ME 15561. work under'this grant is continuing in
writing up the CS? findings and preparing some studies
with Dr. Whiter Seaman of CUNY in Queens College.
The terminal report and additional reprints will be
submitted as soon as the ongoing summaries are completed.

Sincerely yours,

Fink, M.D.
Professor of Paynhiatry

Mix

MF/id

Enos.

�</text>
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                    <text>.1,

'v’

April i6, |970
Dr. Eugene L. Nowickl

Assoclafo Director of
Clinical lnvosilgafion
Lederle Laboraforles

lll

New

Wes? 50in

York,

New

Sfreef

York

IOOZO

Dear Dr. Nowlckl:
l

and nofe
Based on

have read ins dais on Loxaplne Succlnafs wllh lnferesl,
lhaf you have an exienslve clinical ovaluaflon compleled.

fhls data your proposed sfudy is reasonable.

are focussod on lho principal of evaluating
drugs, and from The profile prodlcflng
clinical applications. We are now engaged in early Phase sfudles.
The enclosed sample profile analysis prolocol of one of our recent sfudiss
exemplifies our approach.
Our sfudy programs
The EEG profile of novel

I

The proposed sfudy is no? wlfhln our

Phase

lnleros? ai lhls flme.

in The even? Tho? you have oihar compounds which may require
I
ovaluallons, we would be pleased To review The animal data.

Thank you for your inforesf, and
opporfunify To work fogsfhsr.

l

lrusf

we

will have an

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

�</text>
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                    <text>731~7S7I
13 ﬁavuﬂbar 1973

Dr. Stephen

Stir.

Bivition of Eutectic

and Drug Abuse

Rational Institute of Mbntnl Raulth

Fiahcr's Lana
Rocivillc, Maryland
5600

20852

as:

H3K42-7ﬂw98

Dcar Stave:

I have retutndd from a visit :0 tha-projact "Study of Chroiic
Kanh1sh Uaaro 1n Grcocn" (33H42—70~98) Ind I am writing to bring
you up to date with tha ptagruos.
As you knaw {run your

visit to

Athqa: 1n Augult. the study

callection at data in the tents experiments
in the early spring and the data were analyzad, both in Athanu
anﬁ Haw York, during the summer. A major pattion of the analysts
warn éonn than Dr. A. Liakos unwind in my laboratory for three
vodka in July. -WHon.hc luft, there wet: some tonidual antlynas,
and these Hath couplotad 1n saptlnber and sent to him.
team coupleteé tha

Beginning in Juan, aubjccts warn induetad into the with~
drawnl study and as of November 1. 12 aubjacts hast completed
thc aix~day observation period. I brought the EEG taplt back
to my laboratory on Hovuubct 12. The study tuna in Athens 1.

q.

nears-w

"yr—rm.

v..-

|

aontinuing with the inéuction of subjnctn in thin withdrawal
study and havn set that: tarsut as font additional nubjects,
{or a projactué total of 16. Thay do not baits?! that they
will be shit to ranch 20, but trait that 16 will provide 315~

niﬂieant data.

There have batn no changat 1n the ntaff in staff at Athens.
Despite aw leaving tha Haw York Mbdicnl 0011.31. my cedworkntl.
DrI. Dornbush. Crown, cud Volavkl, aontinua to contribute to
the analysis of that. data.
You should be Ivar. that except for the prsscntation at
thn 1972 818? nesting in Copcnhagnn and ruviuwu at the 1971 ind
1972 tasting: of the ACHP. this material has not bcan palsunted
or publish-d. In ptrt. this rctltctod a reluctance an tha part
of Professor Stefania and.uya¢1£ to prajudga tha data, and I an
culm-

�wanna—nﬁ— h“. 1—H.“ . Y. n-

Dt. Stqphgg Santa

platted

*2~

thtt wt hurl hnnitated. for

7..»

.

w

r. rum...

Wu“ "ﬂu”.r ”pp“,W—

13 Routnbat 1973

our viaws hams undcrgone

changes during the progras: of this study. Profasuor Stefanis
and I discnlaed at length the matter of practicing this material
and praiinionally wt hnvu decided that we will:
(1) truparc a summary for HIKE to supplement tbs
summarits aﬂbnittnd artliar and submit this
tunnaxy with duplicattn of tha data set as
soon as these ate Ivaiidbla.

balicvc that tbs data land thennalvua to
»approxinata1y six to sight prustatutionl Ind
publications in seicntiﬂic journals. and an
'lre prograssing with the preparation of theta
rcporta.
(3) Concurrent with thane two forms cf data ptao~
entntion.*wa believe that the ruports and mate
extensivn data than is stainarily providtd in
journal articles provide a legitimnte basis for
a significant vulva. on the affects of chronic
hnuhidh use in man, and W! plan to nah: sudh a
presentation. (This is particularly important
since the scientists nothing in the Juanita
study appnnutity adopted the utratuzy of pran—
entina their matarial in the pdblic praoa.
instally with regatta glowing tastimaninls of
the curacy of chronit hadhith use.)

(2)

Wk

I balicva that U! will need 1n attention of time if we
are ta attoapliuh the Idéitiannl {our nubjacta. Analyse tha
withdrawal data. writs thn report: to: publication, ate. I
tn aware that at our last Intting in Juae. you: associnta: «are
insistent that the study he annpiotcd by the and of this your.
Shauid this viuv rennin the official position, we will provide

all of thc data availibla to date, including tho with“
értwal dtta, in whttsvar stats thty any be on Decanbur 31.

you with

“a ptafot, howevat, that you reviaw the used for this ttruinn~
tiou, particularly in vita of the fins wart the Gtaok sciontilta havo dong and thc uniquc nature at tbs withdrawal éata.
Wt would raquost an exttnnion of tin» and will prcpnra a bud—
gattry extinct: should your tamuittuc feel that an extension
is feasible. 1 bcliavc that in eatansian to April 30, 1974.
would providn suffieitnt tint to carry out the final phat: at
this study.

�7.
mun;

mum-guru

.
-

m'm'm"m:m'rmww

H17"

.,.,,

.

.v‘..»mw-.g_\——

_V.W.Wm,

Dr. 3tl$h0n_881ra

.w wm—p

WNW“ .1 q-.ry_mwr,_. m."

m-m_-—.u “.-

13

~3—

.-u.-.~,..,ram—w

ﬁGthber

.m. :V‘erI-M'rww'

1973

Yrofousor Stefania tliICd on. administrativh problem
with mnﬁ~that of ch. duvaluntion of the dollar. At their
prestnt rate at uxpeaditurat, 1 d0 not anticipate that the
davaluation will altar ch. budget cignificnntly.

Sincnrely yours.
Max

en:

E.

J.

Gvadwcll

Fink.

M.D.

«w

.7

.-.—

a

A

v“

7,7 .rmw—

,—

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                    <text>Septemer 25,

1963

Nuclear- Data, Inc.
3833 West

Mam,

Boltline

Highway
Wismin, 53791

Gantlamsn:

I

would

like a dasaz‘iptim of the Maximum

102“. as well as the proposed prion.
Very

truly

mm,
Dim
Wmlg

arm.

H. D.

�</text>
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15?.

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                    <text>um
do}!!!

It

Indiana

15, 1963

WW,
mimity Media}. Center

1100 Was:

Ha»

Do

mww

Indianapolis , Indian
Dear Jam:

m mtifioatim of the mating of tho:
WMmWS. We!hndmmdﬂmtﬁumt~
ingwouldbeheldmmingﬁRMWim,Ihmalmdy
omitted myself no matter mimnt that date. I regret
mtxmummmmammmmraeﬂng.m
mldbowimngtommtlminmmxtfwm.
I jmt received

3mm yours ,
Max

Fink.

Director

m:

Harmxzi, M. D.
Mao S. Administration

Vatcm

Renard: laboratories in
Nomvpeychiatry

11mm Farm Road

Pitmbtmgh 6.

Pmylvania

M. D.

�</text>
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                    <text>January 8, 196“

John

I.

Numbormr,

M.

D.

Professor and Chairman
Bazaar'tment of Psychiatry

Indiana mivamity Madioal Gunter
1100 Want Michigan

Street

Indianapolis 7, Indiana
Dear John:

Iwmldmcmmndmaemptaxm ofﬁneabstmctsof

Luby and Hingtgan with me mewatim. Dr. Iiingtgen's abstract
reflects on a highly mannical pmenmtion Wash is properly

Whip

of the society. For this
not within the ken of the
without
and
on
reflection
its writ. I mid assim
any
mam.
lower
a
priority.
it
Sincerely yours,
um: Fink. H. D.

Dimctcm

�</text>
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                    <text>October 1, 1964

I.

John

Nurnberger

Chairman, Committee on Program

Society of Biological Psychiatry

2010 Wilshire Boulevard

Los Angeles,

California

90057

Dear John:
My

assistants

recent

letter.

and

I have discussed the problems presented in your

Two

problems come to mind as central topical areas.

psychiatric research is being done with animals and while
there is occasionally reference made to the species involved many
'young dogs" or
reports are presented in which the comment
"rabbits", etc. These nonwspecific terms hide the great variabil—
ity within the s ecies and among species. We have been preoccupied for years°§n the species differences among humans and espec~
ially the sub~classification of "sick humans". In psychopharmacology we pay a great deal of lip service to the needs of toxicity
studies and trials cf new compounds in animals before administration

much

is'

in man and we know very little about how to translate the observations in animals to men. For these reasons I would suggest one
central area as the interrelationships in observations in animals
and

in

man

in psychiatric research.

During the past decade there has been a great deal of emphasis en

the neurohumors adrenalin, noradrenalin and serotonin. Biochempharmacologists and psychiatrists seem preoccupied in tracking
this model. When we look at the pharmacology of the most ac—
tive psychotropic drugs, examine the most potent hallucinogens, try
to understand the convulsive therapy process, we always come back
to acetyleholine and cholinergic mechanisms. I can not understand
why these have been so grossly ignored ~ unless it is that the
methods of assay are difficult or that the psychiatric leaders in
Washington who seem to set our styles, have followed the lead of
the cardiac psychologists for whom adrenergic mechanisms are most
important. With this background, I would like to recommend a second

ists,
down

topical area, that of cholinergic mechanisms in mental illness.

general ideas of the first topical area which
you if the subject interests you, I
should like to make a special recommendation in regard to the

While

I have

some

I will gladly share with

�'

—2-

John

I.

October 1, 1964

Nurnberger, M.D.

second field. For many years I have been interested in the
problem of antagonists to hallucinogens and during the present
year have been most fortunate in having two associates join my
staff whose interest in this area is also great. I should like to
suggest, therefore, that you consider a symposium in the general
problem of "Antagonists to Hallucinogens as a theoretical model

for the mode of action of drugs". I would like to recommend that
participants include Dr. Gershon and Itil of this staff, Abood
(Chicago), Dille (Washington), Schueller (New Orleans), Zola Horo—
witz (New Jersey), H. Wills (Baltimore), Hock (New York) and
Stevenson (Richmond).

'

Knowing our president, I believe that either subject would
'be of great interest to him. I agree that we should be pre~
pared to have a program focussed on psychopharmacology and I look
forward to discussing this further with you.

I trust those

comments

are helpful and I look forward to

having you visit St. Louis soon. my assistant, Dr. Sletten who
has been in touch with you, should work out a date which is mutu-

ally helpful.

Sincerely yours,
Fink.
Director

Max

mf/ls

M.D.

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                    <text>(richer 28,
Dr. John

I.

196“

Numbezger

Professor and Guirmn
Dapartnmt of Payduiatxy
Indiana University

1100 West Michigm

‘

Street

Indimapolis, Indiana

#6207

Dear John:

I met apologize for continually calling your

is the Chaim of our Residency
with you your“ forthdiscuss
to
Institute. I
your heavy

office but Br. Sletten
Camﬁttee has asked
caning visit to the

W

who

me

sdmchalebuthouldliketheopportmitytodiscusaymm
your pleasure,
at eitrm‘ of these nmbem, Ana Code 31“, Mission s—suus
or Alta Code 315;, Mission 5-8230, Station 517. Would you
please call to collect?

visit. I will be available in my office, at

visit any
mom of
March, AprilorMay. Indoﬁwgsowemuld liketotxy’oo
mmgenotmlytohaveyouvisitushembuttohaveyou
who
We

would be

interested having

you

many-Medan)! or Maw-Wednesday during the

visit

scan of ycmr other Manda

expressed an

interest.

My

in St. Louis

best regards.
Sincerely youm.
Max

mf/ls

Pink,

Dimctor

M.D.

have

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                    <text>Dr. John

Mitten
1100

W,
on

W

Chaim

20., 1961:

Heat Michigm Strum:

Imiimapolis, 7, Indima

Dar John:

Amuaahmmmctmganﬂngapml
that Iwmldlikatoprwme
fwﬁbpmgmmtittu’s
midnmtim for th- 1985 noting
of tin Society of
Biologimchydxiam. Inlﬂwwiﬁzmpiolb. 1, Ihave
mica-the liberty of
w ’usoaiatea and follow
sdmtista md would 11):» m propose
a pawl on the subject
The participants and their
'"Alrtiduolimrgm

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aubjcata

WW".
an.” fellas:

'

‘

Leo Abood: Biochemical Concepts

Rim

W
and

8mm,
M.B.B.8.:

'mmn

of humoumgio

Psychotcmimties
White:
Affecting Cholimrgic
Maxim - Indmad Qumgea

m

MMoml Pattami

Antagmismtomao1W'c
‘

WW

Itil,

-

.

'

Dissolution of Cortical Activity
Induced by Mtidaolirmﬁc Hallu-

11.13.:

'

magma.

Inndpmpmemtlmmmsimandﬁmt
Qumrofdimsmmmuhcteddtharbymepmm
munwmpmicipmtsofthmpml.
Ifthiapmposadpmlmts wimﬁth‘tm's
W,-Iwillbepmpandtopmvidethemoessuyab—
1965
.atzuctamdtotxytogotﬂlemar-BWML
for the- summary.
I

look toward
’

mf;ls

'-

tojoiningyou in Bummer.
Sincerely yams,

m, HID.
Director
HEX

;
&gt;

,

�</text>
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                    <text>MP lit, 19“

'

NW,
of

John 1.

Md).

Professor and Chairmen
Dept.

Psydiietzy

-

Indiana Univ. medical center
1100 w. Midnigm

Indianapolis 7,

Street

Indian

Dear Jolm:

Ihavemviwedallttmabetmcteinwfoldwmdmefoumimammy

mmdetims.
With

much, I
«mum:

the highest

report of the following

N. W. Fox,

A.

S.

‘

would

Salaam
R.

remand the mptmoe of the

W,
m¢1§
Tm,
Adamo, Montreal
P.
Shoide.
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B.
an: H. T. Ballmtina
L. Cessidy,
Flam,
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D.
K. 2mg,
Neylor,
Giantm, and

J. quuez,
Po

J0

H. C.

Sebelli and
.

M.

W.
W.

P. Wilson. Duke Hospital
R. P. Fischer, Ohio State
H. D. mama and C. T. Yeager (San chieoo)
C. Mass and D. N. Trusty. Iowa City
W.

.

Dr.

mm

Moowoeptablnisthe.mportmmmphydologioohmgeeinthebmihof
ofe weak and straw mti—oholinergio hallucinom by
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to him and ask for his
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to include

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this information at the
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symposium.

quadnmimte
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,Aseoondgroupofmoaptablempmmthooetowhoth/avegivenamting
»

S. Gamay, Boston
A. Wade and H.

J.

Whim, British Columbia
Benet-t, Galveston
.

E. S.
H. A. Peters, Wiamin
N. H. Aprism and J. E. Hingtgm,

Indianapolis

�W,

I.
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1mm

Dept. of Psychiatry

mdioel Center

submitted by Dr. Wade and believe that
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disapproval of the other We abstracts
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final

M

E. Ziskind, Ins Angolan
L. Alexander, Boetm
Boeton
J. W. Beasley and J. H. Hendeleon, (U.C._L.A.)
N. E. Soheibel and A. B. ‘Sohoibel
L. Cominikande. Pam-km, New‘lork
M. Pollack and Iridimenberg, New York
A. B.
WIEY
C. R. Hobie, Neeremey
-

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submittedbymyself,
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However, this is
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and
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