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                    <text>twm'“mlm'uwwf'me$M'-mdw'v““ﬁr—gwwwwwamuw-

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212-369 7900 x245

July 22, 1971
ﬂoorge E. McCarthy, Librarian

WWW

Ciba—Geigy Corp.
Ardsley, New York 10502

¢
rwr

wan-n3

Dear ﬁr. ﬂcCarthy,

wzfsw

1w

mgr

We

mm—

.‘K‘I’Z-‘&gt;'xrr17~r»

v

to

me

Your purchase order 1218 of June 30 was ﬂoruarded

for reply.

'

request is out of print. We have,
continued
our work in the development of a quantitative
however,
The volume you

method for the classification of new psychoactive drugs,
and I would be pleased to discuss this program and make the

EEG

appropriate reprints available to your scientist requesting
the volume.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

.W

.‘
“S

~19!”va

_

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                    <text>April 10, 1967‘
Mr.

Preston

New

York,

M.

125 East 83rd

New

McClanahan

Street, 3rd Floor

York

Dear Mr. McClanahan:
Therm you very much for your assistance in the EEGoomputer demonstration. I regret that we were unable to
go ahead with the project this year, but look forward to
doing so in 1968.
-

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MFﬂcp

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                    <text>W

W
Dr.

Jms M.

Mm. Jr.

Univarsity Sdml of
of Psydxiatxy
Baum and
Hospitals

mm
Am

mm Mdubcn
St. touts, mum-5.

29, 1965

A

Maine

63110

Dau- Jim:

ﬂamiﬂwmofehmmmtisbeatmud
mm.
Idomtmofmymlstudyofdmm
Magnum-craftsman
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in "hid: minute mind subthmalwld or supmuxmhold Wt!
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ﬁnmhnnatowuddwtmmdwﬁmmingauniod
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Ywmlloctimﬁutmly
ismtoallmlmdiu.
iwmvudia

Mmimmwmmmamwy
hamper:
wawmumﬁndingamdﬂmeofmtt.
whomwnsive
emvulsive
indicated
and
Brill
that our grows,
didoquanypoorly. Itmmyopinimthatﬂnmforﬂxis
Brillwormwi‘m

by

Whyinﬁuumimofpathnts.
mini-mic; Waves. Macaw
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personality
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Gunmive ﬁnnpymleu helpfulinﬂuis
Mamim.
masmimbctwomemwlsiw
mﬂmhmoﬂur.
mduﬂaamvuhiw,ﬁnnfom.mmypoor.
maitatimsmattadnd. Imgzvtthatittookmafaw

mmmmmu,but1hawbmwayaom¢ﬁmtim

EI;MWWMWMBmHmthom
lg
1.

Imuldbcpleuodtomampyofymmmportvﬁmitis
mutual.
Sincerely yours .
Pink. Md).
mecwor of Paydxiatry

Ha):

Ezkp

�</text>
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                    <text>.

January 11, 1971
Dr. James N. McClure,

Jr.

Eastern Missouri Psychiatric Society

Lindell Blvd.
St. Louis, Missouri
3839

63108

Dear Jim,

I am pleased to recommend Jovan Simeon for membership
in the Eastern Missouri Psychiatric Society. I have known
him since 1965. He is a sincere, thorough, conscientious,
knowledgeable psychiatrist and I recommend him highly.
Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
MF:kt

m

Wm'vvw‘:

my Tut‘s-u.-

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15',

r967

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04. James E. MeCMmaeh,
The New you: Academy 05 Medicine
2 EM: 1034:! Sheet
New you, New Yank 10029
Dean.

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                    <text>-._

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Aprll 23, l97Q
Mr.

Charles

B. McCoy,

Presldenf

E. l. DuPont de Hemours, lnc.
DuPonf Bulldlng
Wilmlngfon, Dalaware l9898
Dear Mr. McCoy:

For more fhan lhree years, fha sfaff of fhls Department
of Psychlafry has collaborafed wlfh Endo Laboraforles ln fhe
cllnlcal fesflng of naloxone ln fhe freafmenf of oplale
dependence. Our flrsf cllnlcal frlals were reporfed In l968,
and slnce +hen we have encouraged Endo +0 make available
sufflclenf cllnlcal materlal +0 extend These frlals.

oral naloxane ls rapldly desfreyed, and fhaf
parenferal naloxone ls hlghly effecflva, we have repeatedly
recommended The davelopmen? of a longvacflng naloxona for fha
frealmenf of oplafa dependance.
Aware The?

Early In l969 we proposed such a development To varlous
agencles, lncludlng fhe Na+l0nal lnsfllufe of ManTal Health
and to The New York Slafe Narco+lc Addlcflon Cmnfrol Commlsslon.
We have recenfly been assurad a? flnanclal supper? from one of
fhase agencles, and may achlava addlflonal supporf from anofher.

for

Meanwhlle, we have requasfad Endo make supplles avallable
conllnued cllnlcal Trials, and once again, as ln l967-68,

hava recalved verbal assurances That fhe supplles will bﬁ
forfhcomlng, bu? fhey fall #0 malerlallze. A copy of our
communlcaflon ls enclosed.

lafasl

wlfh control assumed by DuPonf, and anflclpaflng The posslblllfy
of some changes in Endo's prlorlfles in fhe healfh care fleld,
l dlscussad our problems wlfh Dr.
Jurg Schnelder of your company
In February, and receivad a sympafheflc hearing.

"v“

'

�I

am

wrlflng

Today +0

brlng naloxone

To your

alfenflon.

Naloxone has some speclal publlc healfb posslbllllles. If
warrants a more rasponslva managerlal leadershlp ln maklng
oral supplles avallable for'audy, and ln exploring all feaslble
approaches To a long acllng parenferal form. May I ask your
alfenflon To fhls lmporfanf chemlcal and your encouragement ln
maklng fhe suppllas needed for conflnued cllnlcal sfudles?

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MP

:

kp

cc: Dr.

A. M. Freedman

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                    <text>7333680
”‘1’ 29th .. 1973
Al Heisman, Ph.D.,

Pfizer Inc. .

Gretna, Connecticut

MAJ-9‘

I very

much

«mom your

of the drugawry
new drug identiﬁcation.

bun
seemed so extensive. that I
3mm
and to
an writing to thank you far
M10112:
drug interactions

at the

ECDEU.

33'

Your

for

u

ask whether you cauld make

your
copy

a.

an.

«0:1th. to m.

few years ago. Sun Irvin organized a. similar
at the ACEP, and I understood he mtcd to
u but I do not rec-.11 seeing
If he did
pal-Mp: there is room for mob o. volm, with

session
publish

A

it

not,
report- ,nmilur to

it.

then presented at

ECDEU.

w but roman.
Sincerely yours.

ﬂax

rink, NJ).

Profouor of Psychittry
Mir/13

�</text>
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32f gé;;$ﬁxf

June 11, 1990
Layton McCurdy, M.D.
American Board of Neurology

&amp;

Psychiatry

Institute of the Pennsylvania Hospital
Street

111 N. 49

Philadelphia,

PA

19139

Dear Dr. McCurdy,
Like many of

my

peers,

I am

writing with regard to the proposed

Qualification in Neurophysiology" which is considered for
physicians qualified in Neurology. By excluding those qualified in
Psychiatry, I believe that the Board is inadvertently excluding a large
number of very qualified practitioners whose skills and interest in
"Added

electrophysiology complement those of their neurologic peers.

referring to those psychiatrists with interests in
quantitative EEG in assessing the effects of psychoactive drugs; those
specializing in the analysis of sleep EEG recordings; and those
interested in multi—lead EEG recordings in assessing patients with
affective illness who may be candidates for anticonvulsant therapies.
I am

certified both in neurology

psychiatry, my work in
pharmaco-electroencephalography is clearly of little interest to my
neurologic colleagues, but is central to a whole discipline in
psychopharmacology and psychiatry. Similarly, the work of my associate,
Wallace Mendelssohn in sleep studies, which is an important asset in our
While I

am

and

psychiatric assessments.

Clinical psychiatry has undergone at least three major
revolutions in my professional lifetime-— from the psychodynamic era in
which I was trained at the William Alanson White Institute; to the era
of psychopharmacology; then the excitement about neuroscience; and now
the return to our interest in neuropsychiatry.
By limiting the Iadded qualification’ to that small group of
practitioners who meet the criteria for Neurology would be a disservice
both to clinical practice and to research opportunities which are now

unfolding.

hope that the Board will see the wisdom of either not
added qualification in neurophysiology to neurologists, or
doing away with the added qualification in its entirety.
I

limiting the

Thank you for your consideration.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

ABPN

(P54) (N52)

�</text>
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                    <text>'v-nwxmnu'rrw-wrwr;

.

.m-wwvw—awm. MW..."

.«r .»

m

a...

November 23, 1970

Dr. James MCGaugh
Department of Psychobiology

University of California at Irvine

Irvine, California

92664

Dear Jim,

tell you that I very much appreciate
candid
and
response to my inquiry. The proposal
prompt
your
for a conference on memory and ECT (ECS) has been favorably
received, and is now ”in process". As soon as I have any
Just a line to

"news",

I'll write or

Many

call.

thanks for your

interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszt

-'-"'—'—mmwu :Vnw- p.

q

way-.2

.mw—

�</text>
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                    <text>January 28, 1971
Dr. James McGaugh

Department of Psychobiology

University of California at Irvine

Irvine, California

92664

Dear Jim,

draft copies of the proposal for our
conference. I would be grateful if you would edit one and
return it as soon as practical.
(1) Please check the text for a summary of our
Enclosed are two

ECT

recommendations.
and

,

invitees should also
notes to delete are invited.
(2)

The

(3)

Please add

(4)

Any comments on

.

A,

..

work done".

._.

.

_..

.

3~5

be reviewed and

citations to the list for “previous

,1.

.,.»

W1.

.1”

the provisional budget?

-

My

thanks for your guidance and sound advice.

arm—wrnv—rvz'm

Sincerely yours,
.

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc. (2)

additions

�</text>
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                    <text>Heron 8, 1971

Dr. James McGaugh
Department of Psychobiology
University of California at Irvine

Irvine, California

92664

Dear Jim,
The application for a conference on the psychobiology of
has been completed, and I am enclosing a copy. Your suggestions
were most helpful, and have been recommended almost in their entirety.
ECT

Williams believes he can get the application before the
appropriate committee in April.
Tom

Seymour Weingarten of Plenum wrote of your new publication
and asked about publishing this conference. I asked that
he send whatever descriptions he develops so that we can make a
decision. Good luck on the series!

series

My

thanks for your help.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt
enc .

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                    <text>CM’MW

“In...“ .

731:003CT

January 1. 1973
James HcGaugh, Ph.D.

Profeeeor of Psychobiology
University of California

Irvine, California

92666

Dear Jim,

sent the enclosed contract for the publication
royalties, I opted for the lower
market price for the volume, allowing for some return for the editors
by using grant funda for editing. The Association can make $1,500
available for editing, thereby aubventing the voluae'o coat to the reader.
of the

Mr. Erlbaum

ECT

volume. In diacueaing

The

contract includes our connittuent to deliver the manuscripts

by the end of February, with the volume to be issued in September. Mr.
Erlbauu sent me a sample cepy of a book ieaued by his group and
compares favorably with recent psychiatric volumes. Furthermore, the volume
will require no typing by my staff, for the text will he not by linotype.

it

If the contract in satisfactory, please sign and return to me.
As to what has to be done this month. there are three things

that are required:
soon as

1. Your report to the Conference should be submitted as
practicable, but no later than nid~February.

2. Your review and editing of the reports sent to you, for
such comments as you may wish to make, particularly to avoid inconsiat~

encies in the volume.

3. An overall summary of the meeting wee part of our committment
Such a summary was requested for the use of the various NINE
committees and for publication. It is my understanding that Dan Fteedman
has agreed to review these summaries for the Archives of’GoneraZ Paychiatry.
Although we have agreed to publish the summaries separately,
may be
advisable to include them in the volume as well. I believe this would
be most useful, and while
will require special permission from both
Mr. Erlbaum and from Dan Freedman (should he accept), I would like your
permission to make such an effort.

to

NIHH.

it

it

Despite our individual busy schedules, I hope we can make these
committnente -~ the report for the volume, the edited manuscripts. and
the summaries, all by the end of January. My best wishes for a healthy

and happy 1973

I

Sincerely yours,
Max

Fink, M.D.

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                    <text>731~631

April 19. 1973
Beynour Kety, M;D.,

Professor of Psychiatry.
Ehrverd Mhdieal ﬁchool,

hissechnsetts General Hosyitel,
Fruit Street.

Boston, Ma”. 02121:.

5

Since reading the summary of the ECT conference. I have
had time to reflect on the eenelusions. I as writing to reise
some questions. not about the summery presentation. but the
tonelusion of the role of cholinergic mechanisms. As I

understand the relevant paragraphs (page: 5a6), the date for
the role fbr seetyloholine ere unimgressive. and do not meet
the ariterie fer relevance, set teeth in your earlier
peregrephs. The persgrsph focuses on the report by Karcxsnr.

years ago I reviewed the data relevant for a
(1) I fbund the ehenges in cholinergie
measures ta have s time tour-e similar to the heheviorel
(end electrogrsphie) effects. (2) Specificity was herd to
demonstrate, but eerehrel trenme and neurological illnesses
did not exhibit the seas eholinergie effeets of seizures.
(3) Using sntilhelinergie drugs, I was dble to reverse the
electrogrsphia and behavioral effects of EﬂT. The date are
not avervhehsing. but teken as a whole, the ante impressed
me that eholinergie mechanisms were relevant to the ECT process.
Some

ahelinergie hypothesis.

objection to the hypothesis is thst entheholinergic
drugs. like Ditrqn, have elinieal entidepreesant activity;
end the suggestion I msde in 1958 that iuiprnnine has
entieholinergic activity also refleets on e eholinergic
hypothesis.
An

In your summary in Doredo Beech. you viewed scetylcholine
ss relevent to the seizure threshold and as reflecting the
widespread activation of neurGBS“, without specificity. I
thought then that your argument use cogent. Particularly,
that seetyleholins. es en ubiquitous trunsmitter, may reflect
the inpeet of the massive discharges oceseioned by the eeixure~
inducing agent.

But

this hytotheeis. of nonuepecifieity, is

�Seymour Katy,
on no more

~2-

April 19, 1973

substantial footing than the suggestions of

epeoiticity. Indeed, the more prudent course may be not to
enticipete which neurohnaor is the more important, but to
reflect on all.
for the role of biogenie amines

who evidence

changes in protein synthenie in

part, this

may

and

is well documented. In
reflect the availnbility of adequate and
BOT

toehnioelly simple

methods of nnnlysie. In ooneidering the
ohelinergio hypothesis, vn are faced by the technical problems
and ineoouracy or hionsaay methods. Such difficulty must have

contributed to the peueity or studies in ECT. I knoV'thnt
this technical difficulty has deverely impeded my studies,
for when we did biouetdye for AOh, we found them too unrelidble.
But. from this vantage point, descriptions of improved methods
for assaying acetylcholine (gas chromatography - mesa
spectrometry en deeoribed by Jenden at the ACE? in 1972. is
an exonple) encourage me that more adequate tests of oholinorgie
hypotheses in

ECT

are feasible.

will be read and en your opinion is highly
valued. your conclusions may influence further studies of
ECT. Alex did not present the oholinergio date well; and I
Your summary

cannot do

better.

Presuming on our companionship, I am enclosing a copy
1966 summary. The data are meager, but may be nutricient
to quicken your interest in presenting the cholinergio date
with slightly more optimism. Should you wish to do so, fine;
thould you‘wish to ignore this point, I will not be offended.

or

my

:
"T

5-12-17va

3.9.

you

The volume in almost complete, and once again I thank
and encouragement.

for your advice

my

":7'1(‘l

':3

best regards,
Sincerely yours,

nmwv-w—

“If
-r=:

Mex

12m

MF/id
Ene.

Fink,

M.D.

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                    <text>..;

,
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.
-

7325-606

April and, 1973

SW

Katy. um. .
Premium of Psychiatry.

Harvard Median school.
Massachusetts General Boapuul,

Fruit street.

Boston, Mass. 0212!».

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v

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Dear

Squaw.

v

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1,,

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‘

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have met Larry m-l'bam and found him personable,
and cooperative. I think. it will be a
Magma-e doing “amines: «with him. All the doom“
but We have been some ta him.
for the summary
far the section on Chemistry. your work for this project
is complete.

madame,

mm

W best regards .

wqu.u~;,,.—,.m,,..,&lt;,.‘

1-

sincerely yours ,

WWW,

ﬁnk.
m
Enautive Director
MOD.

30/13

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                    <text>Matéb 28, 1970

Thomas McClashsn, &amp;.D.
Program Head
HIMH - RM. 9m101

5600 Fishers Lane

Kockvills, ﬁsrylsnd 20852

Dear Dr. Moﬂlsshsn:

associates

anticipate our participation in tho
invastigstors in Spring Grove.
1 do not know if we are ”due" for an individual presentation. If
so, the enclosed summary will be elaborated.
Hy

and I

June 5, 6 meetings of the
Should

stract it)

it

for the

ECDEU

not be "dun". you
ECDEU

Intercom.

may

wish to use this (or sb~

it be appropriate, I would be pleased to send this
to the present list of active ECDEU investigatiors and committee members, if you could supply as with this limited list of
Should

summary

nsmss and addresses.
Many

thanks.
Sinner-1y yours,
Ha: Fink, ﬂ.D.

Professor of Psychiatry

HF:ig
than

�</text>
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                    <text>731-605

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April 2nd, 1973

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Irvine. California...

Mr Jim,

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for chucking
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volume.
the proofs for the
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                    <text>73§B~3237

February 7, 19:3

mom ‘H. Mink-m, $122. x
.

Fragram Head

.2£v31uat10n Gait
‘

Early Clinical urug

Institute Ii Rnntal Baalth

Rational

5630 2133.23 Lane

nockville. Aarvland 23852

IDIar Lem; 7‘_§«3

rIaR Rbhf
I
meeting. I Rgliave

nocé raaarﬁing the ntoaram
tbs ﬁragram1s a 200R Rue.

1eﬁj2gthy

ECBEU

for the

fhe- inRRVRRual nresantations are quite scattered, hawever,
inuivigual presentationg are useful for communication.
ariggxng_tagether wankers w521o have studied a single campound may
and walla

atrit.

'akse

are under inveatigation
iaboratorigs.
it be RRRRRI to ask the monitors
to 1uv1cc the various participants to hold an ggea session the
evening befase, ct thI Ivening nits; the LOSER pruaram? By nroviding
-a framework for R public discussion, those 1ntIrIsteR can participata.
Rave
in a numbar of

-

,

I;

30th 91R031RI

think}ya“!

and

GR?

8363

WoulR

mmdatlom an

an intatast1ng maating.

goo-:1

amt look forward to

Sincarely yguRS,

'Proicnnor of ngehiatry
"

83:15;

cc.

21.1).
ﬂuid :1.Ingolhardt.
Lahmann

3:.Rain:

acnrﬁe‘ﬁxqggpn

3.:

A”

�</text>
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                    <text>w‘w—

rm WwW-WWULKHVU‘

TBSB~523

?dbrunry 6th, 1973
Thomas R. McGlashan, M.D.,

Program saga,
Eurxy Clinieul Drug Evaluntion

National Instituxe
5600

richer: Lane,

at

unit,

mental Honlth.

Roakvillo, uhryland 20852.
hour Tam,

tha

I read

EGDEU

your lengthy note regarding thc progrtm for
it 1: u.good one.

naetins. I believe

The indiviﬂunl presentations are quite scattered,
and'vhile I think this is a useful medium of aoununicatlon.
tho idea ot'bringing together workers who have studied a

tingle compound any clue hnw‘ nnrit. It seams to an
thn$ 91393163 and OR! 8063 are under investigation in a
nuibcr of ldborntories. ﬁbula it be useful to ask the
monitor: to invite tbs various participants to hold In
cyan session the avening~befora, er the evening after
tbs EGHEU prograa? By proviaing a frsmavork fbr a publie
discussion. those intorcatod can participate.

I an partieulnrly interested in George Simpson?dtgaulsion an patterns of drug ate and am sending him a
survry at the expericncou in Missouri in 196k. Pnrhnyu
he vauld eomunut on the sixiluritiea or differencna botwacn his
exparieneos 3nd those rccordcd eight years age.
I think year

reaomnnndntians are good tad look torvurd

to an interclting maoting.

Sincerely yours,

Fink. M;D.
Prutanaor or Puychiatry
Mix

xvii:
cc. to nuvid x. Engolhurdt,
Dr. Reins Lehnsnn
Dr. George Binpuon

M.D.

.-

�</text>
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                    <text>i
e...-

E

secember 5, 1972

Mary McClaughlin, M.D.

Commissioner of Health
125 North

noom 604
New

York,

Street

New

York

Dear Dr. HcGlaughlin;

I want to express my appreciation for the opportunity to
participate in the seminar on the possible role of propranolol in

narcotic addiction.

ine session

Yr“!

was most

interesting

and

useful.

While we would be pleased to undertake a direct test of the
narcotic antagonism of propranolol with heroin “challenges“, you
should know that we have been enjoined from further research studies
at Aetropolitan Hospital, and until'we relocate our laboratories,
this interesting study will be deferred.
we have had difficulty in obtaining payment
animal
for the
toxicology studies of diprenorphine (J~5050), which
we undertook in good faith in Hatch 1972. The assays are almost
complete, lacking only the final review of the histological slides.
Hr. Jacobs of your staff has been most helpful, and regretfully tells
us that reimbursement can only be provided on completion and filing
of the report (the “product”), and its approval by agencies of the
City. I have communicated this to Dr. Woodard, the subcontractor,
and it is difficult for him to accept such an interpretation of the
contract. As a small business, he feels that he is in some diffi—
culty, lacking any payments during the course of the work.

Parenthetically,

Perhaps, you can exert your good offices to assist Hr. Jacobs
in gaining the necessary approvals for the statements already submitted.

�December 5, 1972

Mary HcGlaughlin, M.D.

Because the subcontractor has expreseed his needs so force~
also sought the aséistance and advice of SAQDAP, on
fully,
the assumption that these data, once in the public domain, will ex—
pedite the filing of an IND, and the testing of diprenorphine (H~5050).
we have

Again,

ticipation in

my

thanks for you consideration in inviting

a most

interesting session.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

31'!"

2

if,

my

par«

�</text>
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                    <text>July 9, 1971
Dr. William H. MhGlothlin, Ph.D.

University of California,
Department of Psychology
Lon Angelaa,

California

Loo Angolas

90024

Dear Dr. MoGlothlin:

reports of our various studies of cannabis are enclosed.
Our three ongoing studies, that of acute trials of marijuana in
volunteers, chronic marijuana trials in voluntaora, and tho
central affects of haahiah uaa in Graaca, era in tho data collection
phase and should be ready for publication late this fall.
The

Sincerely yours,
Fink, 24.1).
Profaaaor of Psychiatry

Max

MF:kt

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                    <text>_’.~.Wr~a'va.
§&gt;

.

mu.

..

MN.
.

,

.v

V

.

.

,..

‘

,- .r

. .».~

_

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,

A:

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,

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7v.

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.w ,.

é:

7333-80853

11 December 1973

Thelma Jones, M.D.
8

Harvest Drive

Scarsdale,

New

York 10583

Dear Thelma:

Please accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Metropolitan
Hospital. I have found your enthusiasm and cooperation inval—
uable in supporting our explorations into new use: for untried
drugs. Without your help. our evaluations of naloxonc, naloxone
pamoate, levomethadyl, ciclazocine, and many others would not
have bean successful.

best wishes for the health of your family
cess of your practice,
My

and the auc-

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

W

�</text>
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                    <text>July 23. 1964

:9“ Ha

Knetﬂth. ”an.
Assistant Ditactor. Cltntcal Boaoaroh

ﬁofﬁaanana Rocha. Inn.
120 South La Sallo Straat

Chicago.

Illinois

60603

Dear Dr. Mcczath:

thank you vary Inch for the supply at the 10 mg. capsules of
libttum and the placebo. Wk havo coupaxod those to a supply
of Kaila!!! providad us by sandoa, and I am pleased to say
that thay at. tootattosutahablo.

racontly toviowad our protocol and have so: the dosage
range to: sack oapaul of libziun as 10 us. For tho full year a
annoy. wa aatiuato that no will need 16.000 capsules of llbrium.
10 man. cock. and a lika amount of plaoabo. “a barn asked
Sande: to provtda us with 8. 000 capsules of placebo, and would
taquaac that you supply “a with a Ilka amount.

Va hawa

In tho avant that this can ba accompliahad, wa ara prepared to
undartaka chia asndy beginning early in August.
Dr. 1:11
and

is looking forward

I ragrat that

x

will

on your

visit at the and of’July.
I am aura that my

not ha pronaut.

aaaoctataa will provide you with‘a olaar picturo of our program.
Your communes V111 ho non: appraciatad.
Thank you

to: yoot cooparation.
Sincerely yours.
MIX

Fink.

Btractor

HIIJB

HOD.-

‘
.

�</text>
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                    <text>May 26..

mm

Dr. John
Aspirant Directcr of Clinical
H.

1985

Bazaars}:

befwkIaRoohe Ins.
Suite 1268 - 120 Sonth Walla Street
(lineage,

mar

Illinois

80503

Dn. PbGrath:

mined

Our
is
drug study
The so—ccﬂimtor sf the project. Kiss

very well.
plum pmmssingindicates
O'an.
10mm, ismming
tintharsupplyofWof‘libﬁm.
law. She masts a, 000 additional capsulss.
Tm pmvims supply was Order Ho. 06220-01, and if they
be
can
(mitigated it would be appreciated.
'Ihank you

for your co-opsmtim.

Simmly yours,
ﬂax Pink,

M.

D.

Professor of Psychiatry

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                    <text>Febmary

Dr. Jam M. Wrath
Assistant Director of Clinical
Hoffman-We. Inc.

suite

1966

Ram

- 120 South LaSalle Street
Illimia 80603

1285

(him,

mm:

Dear Dr.

As you

{mow
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from Dr.

ridaﬂne.
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patterns.
To aooonpliah this in a reasonable tin interval, we
have owloyed addition]. technical assistants. I am writing

tomqmatymappmvalfortheminderofmgmntmdaid
whidmhaabmmidemd torﬁxiaatudy Itwmldbe

helpful to receive the balance
the next month.
Thank you

orapar't ofthe balmoewithin

for your maistame.
Sinmrely

yen-ma.

Fink, M.D.
Rmfeaaor of Psychiatry

Max

MF:jmh

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                  <elementText elementTextId="102042">
                    <text>May

23, 1955

Director of minim). Research
Assistantmm,
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H.

HOD.

Inc.
BMW-Wm,
120 south manna Stunt
Chicago.

Illinois

mar

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                    <text>Novomba' 26, 1962

Training Material: &amp; Information
Services Division
MoGraw Hill Book Company
330 W. 42nd street
New York 36. N. Y.
Gentlemen:

appreciate copies of the two reports recently prepared
by your Dtvtuon for the United Status Public Hoalth Sundae conference
held at the Audio House. The reports included, an outline of a biomodloal munch information :yntom and uoondly, a genus! donoription
of a computerobuod information retrieval system.
I would

'

If 01mm of

then reports are in the public domain.

appromato mounting copies. It
prior to tabulation.

I would

thou are any oharqoa, pica so indicate

I

Thank you for your cooperation.

Sincerely yours.

'lwwo—pw

MISSOURI INSTITUTE OF PSYCHIATRY

Max Pink. M. D.

Mrzaw

Director

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Book

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00., Inc.

York, Nun York 10036

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in electrical 31ml:
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                    <text>April 6, 1957
Mr.

J.

E. McGregor

Personnel Administrator
Control Data Corporation
L$201

Arden

North Lexington Avenue
Hills, Minnesota 55112

‘

Dear Mr. McGregor:
Mr. David Bridger was on the staff of the Computer Center
of the Missouri Institute of Psychiatry early in its development.
At the time we were installing an IBM 1710 control system for
the analysis of neurophysiologioal signals. Mr. Bridger had
unusual capacity in understanding the equipment and the variety
of housekeeping programs. At the time that the first disk file
was instituted in St. Innis it was at our installation.

Both in the development of new equipment and in providing
programming for sane of our projects, I found Mr. Bridger

unusually capable.

to

make

the disk

When

other systems engineers were unable
he was instrumental in providing

file operate,

the necessary programs.

'

I would recommend him highly for any position which he
thinks he is able to fulfill, especially those which required
the integration of electonic equipment and programs.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>member 22,
Dr. McKeen

1966

Cattell, Editor

.Jmmlofﬂemega
1300 York Avenue
New

York,

Déar Dr.

New

York 10021

Cattell:

I rave mceivad the galley of the article "Clinical

Mal
of'miothixam inSchimphmnia" arxihavemadeafew corrections.

IravesentittomyassociateainSt.Lmisandttcywillmtum
The
cormctionaminthetables and, ifatallpossible,

ittoyouassoonastheyluvoradacrmtocrnekit.
principal

Imuldappreciateanopportmitytoseeagalleyafterthe

Myouverymhfwmprunpt
New Yum.

best regards for the

considerationandmy
.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>-

"w. Wlww'—Wuu

~;--'m"mw1yaj‘nr-V'-v‘&lt;mwx'ﬁw awv‘

.

~

May

mum.- ..

-

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17, 1976

William T. McKinney, M.D.
University of Wisconsin Medical School
Madison, Wisconsin
Dear Dr. McKinney,

I am pleased to write this
behalf of Oliver Nikolovski, H.D.

letter of

recommendation on

I have known him since 1967 (or 1968) when he joined my
staff at the New York Medical College as a staff research
psychiatrist. He was assigned to the out-patient department where
he has served since. He participated in a-aunboI-of clinical studies,
particularly evaluations of new psychoactive substances in the
treatment of the mentally ill. His work has ail-yr been exemplary) 44
e is a methodical, reliable, and careful worker. He is liked by
his patients and ie-ebte-to create a cheerful atmosphere with

his co-workers.

I relinquished the role as chief of the clinic, he
remained as therapist, and from time to time, participated in ”‘27‘~“§
Jay experimental studies. He has always been willing to assist in
studies and my co-workers have called upon him after I left the
College in 1972.
analmﬂWhe

-

has been unhappy at the College since
has not
he§2::;;ra
received the professional advancement that he
I would
recommend him for any clinical position similar to those which he
has held, and believe him qualified in clinical psychopharmaeoloé;¢?7?‘é‘ﬁ
and psychopathology. Unfortunately, I have not had the opportuni
to assess his teaching
as these are under the supervision of
others at the College,
“1&amp;5WWW/I.)
He

,//”

I trust these remarks are helpful.

.w'l/W

jﬂsdhobﬂg ,u,9'

3

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

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                    <text>lbvuibnr 81h.11972

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a1nacroxy yours.

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                    <text>t.

J’K'a—

.,

—.—s-_'_:

e

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
The Provincial Hospital

Postal Station
St. John,

New

B

Brunswick

Dear Dr. McLean:
Dr. Haque was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

‘

I found him cooperative, alert, and enthusiastic. He carried
his responsibilities well and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. He was among the
better residents which the hospital produced.

m..-

"11"

1-"

mm"...

I

am

pleased to

is qualified.

recommend him

for

any

position for

ny—g-v

7

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

which he

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                    <text>wermrnrmwu

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
Provincial Hoapitel

The

Postal Station B
St. John, New Brunswick
Dear Dr. McLean:

Dr. Hague was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

alert, and enthusiastic. He carried
and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. ﬁe was among the
better residents which the hospital produced.
I found him cooperative,

his responsibilities well
I

am

pleased to

is qualified.

recommend him

for

any

position for

Sincerely yours,

371m

(a.

r‘w-Wznhy

Max Fink, M.D.
Professor of Psychiatry

which he

�</text>
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                    <text>April 11, 197h
TAMARATH K. YOLLES, M. D.
MAX

FINE,

M. D.

Alpha~0mega~Alpha

As e member of the New York University Chapter of
Alpha-Omega-Alpha, and a member of the faculty of S. U. N. Y.

at Stony Brook, I am pleased to support the application for
a charter of ADA for the School of Medicine of the Health
Science Center of

this University.

Fink, M. D.
Professor of Psychiatry
MEX

MF:ed

�</text>
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                  <elementText elementTextId="106677">
                    <text>7.,4.‘

,,

“MM...” .._.,,......

W.

NV

.

.

7388~626

H

‘

»...,,..-w-w..~u-~T.n-‘Hmy

.»

,

- ~- .

”an

‘

«.wr

r

""

»-

~-./

Agril 16, 1973
mo:

Leonard E. Mbiselss, M.D.

max:

Max

SUBJECT:

Control of drugs on campus from.the University Countel

Fink.

116.1).

namornndum

2/26/73

In response to this llnnrandum. I have dincuased the new
regulation. with representatives of thn Narcotic Control Bureau
of the Bogartnent of Health of Haw York.
Present regulations are being interpreted that individuals
individual labaratories are to be licenssd, rather than
institutions. excepting hospital pharmacies.
and

In tddition to conplying with New York State rnguletione,
applications must also be made to the Bureau of Earcotics and
Dansaraua Drugs. The pwoper sequence for a scientist is to
take application and obtain approval tram the ﬂaw York State
Dopartmcnt of Health. and based on this approval, apply to the
Bureau of Narcotics and Dangerous Drugs. (Depending on the
project, separate additianal applications are ordinarily made
to HIKE, FDA and other agencies which actually supply controlled
substances).
Because of the couple: nature of the regulations, it would
be advisable for the Health Scicncas Center to appoint an officer

with tho rnsyoncihility to: .‘ “maintain a file of pertinent
resulstiona; (a) advise mamhefs of the Health Sciences Center
professional staff in matters of complianca; (3} mnintuin records
of approved application: within the Health Sciences Center; and
(b) coordinate tho use of facilities specifically nacesaary fur
the control of thase subatanccs. ﬁnch an officer should natify
periodically (unannlly?) the ﬁles ?reaident for Health Sciences
of thn status of applications and tho use of contrailed aubutnnaos
in tho institution.

or a single application from a single office
for research in controlloa aubutances is not foasible at this time.
The conuept

HF/id

'-"'

�</text>
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                    <text>73813-722

June 2181;, 1973
Dr. 1.. Image,

Department of Neurology,

Central ﬁddle-ox Hoapitsl.

Park Royal.

London, HALIO. Engllnd.

Dear Leo.

as

a. pleasure meeting you in 088, and the
It
time of our got—togather
an too short. I must
say again hm: impressed I on with your progress in
settim up a. study unit. We are new determining the'
dosage of amitriptylim. I Just received the (EB—~93:
this week and should begin w studios during; July.
,

-

I

am

m

writing boosuao

Mort,

a.

’

vary close friend. Dr.

W

prwticing psychologist from our
is on his any to
for his bonds”.
omnity.
no is s longtime sufferer with s homisted lumbar disc
,
sud hos suffered surgery. He has bud a recurrence
“sonny, sad is new: in sons p.113. This is sufficient
to mks him feel mooﬂorta'ble, but insufficient to
keep his from his bonds” He sskod my advice so to
tho
of a neurologist that ho might see in one he
hsd difficulty. and I have taken the liberty or giving
his
at Central landless: Hospital. Should
ho can. you, I would be mtsful for why assistance
th'st you may xiv-s his.
Melvin

a

m
mm

'0' best rowan.

812:“:st

yours .I

m nut. "09‘

Professor of Psychistry
Ill/1.1

�</text>
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                    <text>7483-02933
18 January 1974

Daniel

APA

X. Freedman, M.D., Chairman
Commission on Drug Abuse

University of Chicago
Department of Psychiatry
950 East 59th Street
The

Chicago,

Illinois

60637

Dear Dan:

I have read the report of the

on Drugs, as

written

by Roger.

Ad Hoc

Coordinating Committee

It is

quite clear that there are a limited number of na~
tionslly~known consultants who are called upon to respond to‘
national issues in the form of drug abuse. Because their num~
bars are few, they also are also called upon by various national
organizations. It was my understanding that the AMA Committee
on Drugs had for many years assumed the leadership in the field
but because their membership reflected nominations primarily
from them , that committee did not reflect the opinion of the
younger, progressive members of the other
developed an expertise in this area.

societies who have

proposal by Roger suggests the establishment of an APA
Council on Controlled Substances and Alcohol, with a budget in—
cluding a consultant. I concur with this reconnendetiou but
would suggest one additional step. Perhaps the APA would con.
sider the development of a National Council on Controlled Suh—
stsnces and Alcohol to represent the point of view of the APA,
ACNP, Society of Biological Psychiatry, NRC—HAS Committee, Ameri—
can Psychopathological Association, and such other similar agen~
ties of which you are a leading member. Should many of these
organizations be brought together and should their treasuries be
tapped (expecially the ACE? and APA), then one can envisage sup~
port of an active office in Washington to represent the various
views of these organizations on drug problems.
The

At the least, I am writing to concur with the recommendation
of a council and a consultant for the APA.

Sincerely yours.
Pink, M.D.
Professor of P sy-chiatry

Max

MF/cis

cc: Roger E. Meyer,

M.D.

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                    <text>r7.

.

,

~.,.'.._._.~mmwvm-v '3'".

WWﬂW—v—m

-

-

-:2-

~—

,

w'mr‘wnwn‘n

unwahilmw'rwnw‘m‘m‘r '7'“, w": .m

Wynn“.

June 12, 1972

—

r”

w—,

"cw-nun

m,-

F. Gilbert McMahon,M.D.

Department of Medicine
Tulane University School of Medicine
New

Orleans, La.

Dear Professor McMahon,
Thank you for the invitation to participate in the
symposium, Clinical-Pharmacological methods of Drug Evaluation, to
be held in New Orleans next March. I will be pleased to participate
and to discuss the role of EEG methods in new drug evaluation and as

indicies of bioavailability.

In your outline, you indicate the other titles to be
reviewed in the session. If it is of any help, I would suggest you
consider Milton Kletzkin, Ph.D. of Wallace Laboratories, Cranbury,
New Jersey for the review of skeletal muscle relaxants. If he is
unable to carry out the assignment, I am confident he will be able
to recommend someone to you.

Similarly, Dixon Woodbury is well known for his interest
in the anticonvulsants; or, possibly you would wish to consider one
of the more classical neurologist-clinicians as Gilbert Glaser or

Melvin Yahr.

fall,

may

As I will be changing my university affiliation this
I suggest that my address of record he changed to:

P.0.

Box 269

Great Neck,

Communications addressed to

Again,

my

that

New York 11022
box should reach me promptly.

thanks for the

invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Navomber
1!.

Gilbert

10th. 1972

McMahon, 14.13.,

Protesuor of Medicine,
Tulane University School of Mbdicine,
1h30 Tulnnc Ave.,
New Orleans, La. 70112.
Dear Doctor Moﬂhhon.

'I look forward to participating in the session
I meat change in title to -

on March 2km.

D

on.

"Use of the EEG in the identification
and classifiettion of new ysychoactive

agents.”

I would appreciate Mina lined as Ms: Fink, Md). ,
Professor of Psyehiatry, Health Sciences Center. State
University of New York. sway- Brook, 3.1’. 11790.

mil either to the

Yen can stand my
my 13.0. box

address or to
11022.

-

Box

I look toward to using

Etony Brook

’269, Great Heck, 3.x.

you

in

Maren.

Sincerely yours.

Ma: Fink. 14.1).

Professor of Psychiatry
WI 13

�</text>
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                    <text>June 15, 1972

Mr. John Mcﬂiff
334 ﬂowery

Apt. 7F

New

York,

New

York 10012

Dear John;

I regret your decision to leave, for I do believe that you
contributed to the success of the program. but, as Bob and Bruce
are finding their way in other educational programs, I am sure you
will do well in yours.
Good
many

years.

luck in your studies, and
‘

Yours

Max

my

thanks for your help these

truly,

Fink,

M.D.

Professor of Psychiatry

HF : 1g

P.S.

We

will send your check, including earned vacation to the

address given.

�</text>
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                    <text>X.
W:
v,

,

mel.

,(323‘
egg/wt».

1:."

‘
"yew

”1,,

new;

:A

A.

December 27, 1972

James a. JcPherson, A.D.
Chairman
Committee on Internships

Graduate School of Medicine

Mayo

Rochester, Minnesota 55901

"11'
M
galleries!

347:.-.

Easiest:

Dear Dr. ﬂcPherson:

Early in his school career at

new York

Iedical College. ﬁr.

Zeidman applied for summer Work in this division. At that time we
were involved with tne study of novel narcotic antagonists and he
carried out chemical assays and also interviewed patients. During
the subsequent years, he volunteered for a number of experiments as
a subject, in our assay of new psychotrOpic drugs.

In his relationships I have always found him to be bright,
cooperative, enthusiastic, and dependable. He worked well with my
staff and with the patients. I believe he would make an industrious
and

enthusiastic trainee.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Hing

�</text>
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                    <text>“
v~w~:,-,

."‘&lt;-'wru‘e'

February 6, 1985

Mr.

MoQuade,

W.

Fortune Magazine

Senior Editor

1271 Avenue of Americas
York, New York

New

Dear Mr. Mchade:

this

The

death by suicide of

Mr. Black

of United Brands earlier

it ill,

week set me to wondering whether he had been depressed;
he had
he had sought treatment; and then, to musing that even
he
would
have received the
was unlikely that
seen a psychiatrist,
treatment most effective for depression ~ convulsive therapy - because
as? the many professional and lay misconceptions of this treatment.
.

if

it

it

Among

reasons for

its.lack of use are misconceptions about mental
name, 'shock therapy' , and the bade press,
devastating article published by the New Ibrksr this

illness, the{fond-we

exemplilied y a
summer.

Perhaps this is the time for Eortune, as a follow—up of
the article on psychiatry. to assess some of the recent data on depression -— its genetic components. relations to alcoholism, modification
by drugs. maintenance therapies, and the role’of’nechanism of action
of convulsive therapies.
'

Should there be a story here, I would be glad to get you
or one of your writers started. It has been a subject of research
interest for me since 1952, and I can provide the relevant literature
and

contacts.

However, there is another story of more direct interest
to the readers of Fortune. particularly those involved with drug
development that could be examined. For two decades, I and others
have quantitatively measured the electrical activity of the brain
the EEG), and used these methods to predict the clinical application
of new drugs in the treatment of the mentally ill. These methods are
based on digital computer analytic methods (we use IBM, others use
DEC equipment).
They have been developed so that specific applications

are

now

being made.

�Most

of the established psychotropic drugs have been

classified into nine major classes, based not on their chemical
structure, but on their EEG effects in man. Using this classification,
putative psychoactive compounds have been examined and for a number,
where their EEG classification clearly fit one of the pigeonholes, a
prediction has been made for their clinical application. These methods
have been successful in defining clinical uses for doxepin, cyclazocine,

mianserin, cyproheptadine, and a number of other numbered compounds.
The technic has also been applied to definﬁki bioavail—
and
neurophysiologic equivalence of different drug formulations ability
issues that are of special importance to the drug regulatory authorities,
and to industrial pharmacologists.

Lately, in applied studies relating blood levels and EEG
have applied pharmacokinetic principles to the EEG measures
measures,
and defined the halfuulife, peak effect and volume distribution of sub—
stances as they afftct the brain ~— another important issue for regu»
latory authorities and industry.
we

to other research
principii of cannabis in naive and chronic
cannabis users; the interaction of opiates and their antagonists; the
study of alcohol antagonists; and to examine brain function in convulsive
therapy and in psychiatric patients who have failed to respond to the
expected treatment where EEG measures provide the basis to specify an
alternate treatment.
topics

~~

These methods have also been-applied

study of the active

Perhaps this issue is of more interest to your readers -—
surely of greater personal interest to me. I would be pleased
to meet to discuss either or both these ideas. Hopefully, the talents
of the writers of Fhrtune could be put to a broader understanding of these
scientific and socially relevant problems.

it is

My

best to your family.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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m/ﬂ

June 16, 1993
Robert T. McQueeney, MD.
1110 Tenth Avenue
Menominee, Ml 49858
Dear Bob,
Thank you for the copy of your letter to John Greden. The request is rather clear,
but to whom do you wish his comments sent? Is it to you?
Attached is another such note, addressed to you, which you may submit to the
appropriate boards in Michigan.
Good luck in your efforts. My regards.
Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

and Neurology

�</text>
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                    <text>June 28, 1963

Mr. R. A. McWorkman

P. O. Box 103- 6557”
Thayer, Missouri

Dear Mr. Mchrkman:
Thank you for your inquiry.
from Dr. S. Malitz of New York.
As no arrangements have

I

have

as yet been

also received letters
made

for the direct

transfer of out-of-state patients to this center, I

your

Diseases,

such decisions are made.

I trust your

he needs.

son

forwarding
Mental

am

letters to the central office of the Division of
where

will continue to receive the medical care
Sincerely yours,
Fink,
Director

Max

M.

D.

MF:jr

cc: L. Belinson, Division of Mental Diseases, Jefferson City, Mo. (Encl.)
S. Malitz, M. D., New York State Psychiatric
Institute, N. Y.

�</text>
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                    <text>am

23. 1953

‘Hr. R.A.Hddnﬂman

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Itmstywrmwillomtimotomiwtumdieﬂm

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31ml);
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yours,
M. D.

W.

an: L. 8.11m, Division of Hunt-.1
Jefferson City. Mo.
3. Manta, M. 9.. 2595: York sum Psychiatric Institute, N. Y.

(ML)

�</text>
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                    <text>n ‘wwwvmmwvm

w w—wv

Juno 28, 1971

3r.

R. Mechanism

“threw Univarsity of Jerusalem
School of Pharmacy
P. 0. Box 517
Jerusalem, Israel

Dear Dr. Mechoulau:

Septratoly, I am sending you the available notes from our
present contract with Food and Drug Research Lacs. It would be
helpful to have another laboratory invostigcting this problem,
and I hape you can proceed.
I met Dr. Loev in Philadelphia two weeks ago, and we discussod
a systematic study of the TWEIJorivativo. Ho and his associates
cannot release the compound unless either they or we file an 1&amp;9
application with our FDA, an&amp; I left thou coasidorinﬁ their filing

the applicntion.

Moanwhilo I met Professor W. R. Chou at tho University of the
Indies and he reported isolating some now derivatives of
Jamaican hemp. The formulae are onclosod for your intorest.
West

I was pleased to know that your THC is stable and active. I
will uso the runnining matcrial in some experimental studies. The
information was most holpfhl for our relations with our chemists
My

best rognrds,

and my thanks

for your continued interact.

Sincoroly yours,
Fink, M.D.
Profbssor of Psychiatry

Max

MF:kt

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                    <text>February 8, 1972

Prof.

Hebrew

Israel

R. Mechoulam

University of Jerusalem

Dear Prof. Mechoulam,

&lt;7

:-

Mammy-”WV

I have just returned from examining some of the chronic
hashish users in the laboratory of Prof. Miras in Athens. We observed
4 men as they smoked various doses of hashish, U.S. grown marijuana,
THC impregnated placebo marijuana, and placebo marijuana. Our data
is confusing, for the men exhibited 'tolerance' to hashish, but not
to marijuana; they showed behavioral changes to marijuana which seemed
distinguishable from their responses to hashish; and they showed
no reaponse to 75 mg THC.
One

&lt;v:

is the different

of the

mix of

possibilities underlying these
constituents in the

mixed observations

two samples. Before

leaving

Athens, Prof. Miras provided us with another sample of hashish which
has a low concentration of THC, and the men reported this sample to be

'without

effect'.

are replicating these observations in another sample;
THC~A~9 and ~8. I have some
samples of the two types of hashish, and the U.S. marijuana, and I am
writing to ask if you would be willing to assay these for us. There
is some question in our minds as to the actual concentration of the
presumed active substances. May I send 4-6 samples to you ?
and

We

will undertake additional trials with

Many

thanks.

O

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
“swap-7m

vvm-J

rummrvrr‘r'

~
"“7

=

-.

W‘V'm'li‘

mam.

“Mvm‘cvir

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                    <text>Hay

2’4

, 1971

Dr. Rafael Mechculam
School of Pharmacy

Hebrew University

P. O. Box 517

Jenxsslem, Israel
Dear Dr. Meduﬂam:

Itwas agreat pleasure forustohearcfymn‘vnﬁcwith
we are mtt grateful for your assistance in our

cannabis, and

analytic problems.

discussed I am enclosing a swam cf the clinical
the narcotic antagonists, and sore reports from which ym
can obtain the citations for the chenical reports. We believe that
a long acting antagmist is a logical and useful way to treat opiate
dependence and have sought to encourage the develoment of such a
fomzlatim. Should you or your associates be interested in this
problem, we mmld be pleased to go into the details and make
available the notes frcm our present contract with Food and Drug
eRseardi Inc.

data

As we

on

new theoretical interest is the data presented on EA 11476 ,
the l, 2 dinethyl heptyl melon of tetmhydmcarmabinol. Dr. Russo 1
Monroe shand me scare EEG records of the early studies in monkeys,
and these darmstrated a persistent, high voltage slow wave (3 5 cps)
pattern. This EEG pattern in awake subjects, is characteristic of
the post-convulsive therapy state and is associated with behavioral
inpmvement in depression. I am enclosing some early renorts, and
would encourage you (and/or SK?) to extend the trials‘of EA 11:76 in
um.
I an also mclcsing a copy of your report as you requested.
Of

Again, our thanks for your

disassicn.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

HF :kt

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                    <text>October 14, 1971
Dear Dr. Mechoulam,

I will be at

I received your itinerary after your
my

office all

day

letter.

in Thursday, October

21

(212 369 8488), and I look forward to hearing from you.

Unfortunately, I will not be available Friday.

If you cannot reach
on Saturday (516 466 5444).

me

on Thursday,

I should be

home

‘

In Amsterdam, I heard some preliminary data to be
presented in Stockholm, and I believe that should be a very

interesting meeting.

I hope that you will be able to look into the

development of a long acting antagonist.
Good

luck

!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Prof.

October 12, 1971

R. Mechoulsm, M.D.

Laboratory of Natural Products

The School of Pharmacy
The Hebrew Uhﬁversity of Jerusalem,

Faculty of Medicine

Dear Dr. Machoulam,

I can be reached at my home, (516) 466—5444 on the
weekend of October 23rd and 24th.
.,.

”.1“:—

5w

;.

I too was surprised at the response of SKF.
you can do something to change their mind.

Perhaps

"prmp‘

I

7”

'."‘"{‘

do hape

that

you

the long acting antagonists.

will be able to

do something with

Sincerelyﬁyours,
a.
A

f’c'f'ﬁw-

"Jr—1

"‘

'V’Sr‘

,,

gala.

awry-z

“‘71

(7
pr;

'(Vp'

2.-

19.1355»!

s

.;1'/,&gt;r.

6,9"

‘
njrwt

Wt.

mna’mi‘w:

7"Hl'pefit'i-é

$57."

7.va

v.20

Fink, M.D.
professor of Bsychiatry

Max

'ﬂﬁhﬂ“,‘.~;v*

MF:jb

�</text>
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                    <text>19

September 1971

Dr. R. ﬂechoulam
School 03 Pharmacy

Hebrew University
Jerusalem

Dear Dr. Mechoulam,

Following our interesting discussions in New York, I
met with Dr. Bernard Loev and his associates at SKF, to request
supplies of SKF 5390 (EA 1476) and that either they or I file
an IND for studies of this compound in man. He has written that
they are unwilling to file an IND, unwilling to provide the
compound, or to support an IND from my laboratory.
He indicated that he expected you in Philadelphia
about October 11. Perhaps you could visit us in ﬂew York to

discuss this further

?

Interest in a long acting antagonist is all at the
verbal level in the 8.5. today, but if you wish to propose an
attack on the problem, it is altogether possible that funds could

be found by Dr. Freedman.
Have a

pleasant trip West.
Sincerely yours,
Fink, 3.9.
Professor of Psychiatry

Max

P.S. I will be out of the

U.S

until October

8.

�</text>
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                    <text>._.W_,..r... _. .1wh...

.

.

'vayvi- ..

.1.

v...—w...,._...y-v——

-

Hovaaber 23, 1971

Dr. R. Mechoulam

Laboratory of Hatural Producta
of Pharmacy
The ﬁchrew University of Jerusalem
Faculty of Medicine
Jerua elem , la rael
The School

Bear br. Mechoulam:

Separately I have sent you the import permit of

EA

1476.

There is much interest in the antagonists, and particularly in
a long acting formulation in this country. I have attended two meetings
focused on this problem during the past month. The immediate focus of
interest is in naloxona pamoate, which in animal trials releases naloxona
for 10—14 days. we will begin an assay of this material in January.
At present, the two best antagonists are naloxone and l—cyclarocinc,.
Naloxone is enclosed. For l-cyclaaocinc, samples would have to be ob—
tained from Dr. Sidney Archer, winthrop Laboratories. It is also probable
that ﬁ~5050 of Beckett &amp; Coleman may to useful, but neither lccylaaocina
or M—SOSO have racoivad touting in man. Therefore, for the present, nal~
ozone in the drug of choice. Should you believe the chemistry of cycleaocino would be a better choice, I would suggest you write Dr. Archer
for a sample of l-cyclazocino to test.

The testing is a problem. I recall that the Israeli pharmacologiata were able to assay the duration of action in animal subjects, uaing
morphine challenges. Ia that correct? Our facilities permit us to aaaay
the duration of antagonism in nan, using heroin challenges. Ha have not
been able to undertake toxicology studies in our laboratories, and have
been trying to obtain the funda to study M~5050 under a contract. Thio
it under review. Should you uaka some aanplaa available that you believe
has a long release rate, we will try to assess the animal duration (rclcaae) and if intaraating, arrange for the other trials.

�w
rrv ‘mII—u -m,.—,_..vwn—.J,u‘“

.“pwwﬁﬂ.”

.wu.n...,wm,wwwrvywvwﬁw,

November 23, 1971

Dr. R. Mechoulam

chare grateful for

E

'

be remembered to you.

your

interest,

and Dr. Freedman asks to

Sinceraly yours,
..W-wvv'ﬂ

Max

Fink ,

14.1).

Professor of Psychiatry

:ig
lie.

biF
mw—mmrmw

,w—rmm.

v
”.2.”

�</text>
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                    <text>November 19, 1971

Dr. R. Mechoulam
School of Pharmacy
Hebrew

Israel

University of Jerusalem

Dear Dr. Hechoulamm

I

am

pleased to enclose an import permit (#3273) for
air freight, and the permit should

1476. This may be shipped by
accompany the shipment.
EA

I have also received your letter regarding the antagonist.
I can and will send some naloxone, but would like to discuss your
letter with Professor Freedman first, as he may have some suggestions
as to the eventual testing of the antagonist.
you

I trust the lectures in Stockholm were interesting. I thank
copy of the program.

for a

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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rm"

‘&lt;

"P

—‘

rrt"‘W-‘?7"‘

memmMn-ywx-

7383.629

April 19. 1973
Dr. William Biler.
Biomndioal Engineering.
Dovnstate Medical Center,
h50 Clarkson Ave.,
Brooklyn, B.Y.
Dear Doctor

ﬁller,

?or tony yours I have had a laboratory for EEG
IBM 1800 comyuter as a proeesoor.
This winter I moved the laboratory to this University,
leaving-bohind my close associate, Donald Shapiro, 0.3:.
In discussing a replooumont for him. he suggested that
I should write to you and ask whether you had some
candidntoa graduating from your progrtm who might be
interasted in computer applications to physiologioal

analysis, using an

signals, particularly EEG and EKG. If you have some
at the M.S. lcvol that you would recommond
to as. I would appreciate roeoiving copies of their
curricula vitae.
graduaﬁon

Sincerely yours,

m

Fink. ”on.
Proton-or of Paychiatry
MF/id

�</text>
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                    <text>vw. V. .

sm

«v

wwww' W'v—W'w‘w'mr ﬁ-xm'W'Wﬂu-u

*XWW~‘:.~.-n-ghw'mnwnwulwaw; er~-‘-m—

September 30, 1977
Raphael Mechoulam, M.D.
Hebrew University

Jerusalem, Israel
Dear Raphael,

I have checked into the facilities available to me to
CBD. At this time,the hurdles are rather

undertake the study of
high.

Last week, I met again with Professor Alfeed Freddman, my
former chairman, and he reminded me that the research unit vas still
active under my associate, Dr. Resnick. I spoke to him today, and
he seemed interested in the project. I have, therefore, sent him the
file or letters and reprints, acknowledging that he can count on my
cooperation for any analyses that will have to be done.
Dr. Resnick is the principal investigator in all the studies
at the College since 1&amp;6? into the activity of the narcotic antagonists,

cyclasocine and naltrexone. He also assumed responsibility for the
studies of methadone and levomethadyl, and has been a student of
the behavioral and central effects of cocaine.
and

I

I have asked him to write to you for any additional information
hope that he will be stimulated to undertake the study.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

max

.

:b‘w-‘I-wnv'r-

x

.m—

�</text>
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                    <text>-

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Tm-GBT

E

June 11th. 1973

F

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i

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Georg. R. Namely,” um...

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and a! tha Dammit of Paychhtry,

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30: 3932.
no.

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13m Doctor ”unduly.
indeed tn hmr ta be ﬂea-1mm for the cm: in
:t the Sahool of Mqinn 1n Bhr'chport. I have
and I do not believe
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                    <text>May

20, 1971

Dr. Bruce H. Mead, Director

Professional Services

Laboratories
Nutley, New Jersey 07110
Roche

Dear Dr. Medd:

I

Thank you

Itil.
will be of interest to the university chairman

for the

am sure there
who received the

managrsph on E36 and the

reprint

by

mailing.

I know Dr. Itil's work very well, as we were co~workers during
years in St. Louis. Recently, we collaborated in an exhibit on
combined drugs in schizophrenia at the APA, and this exposure was

my

most

interesting.

With your

interest in

EEG,

perhaps you would

connider sn exhibit of the methods of quantitative electroencephalography
as another way of getting the message to the psychiatric profession.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>June 18, 1966

The Mbdical Bureau. Inc.
900 north Michigan Avenue

Chicago 11,

Illinois

Attention:

Wotan: R. Hamilton. President

Gcntlonon:

for your letter of Juno 16. We would appreciate your
rocounondation: of candidates for possible appointmont to this
institute; howovor. the cost of such service would be the sole
rnaponoibility of the applicants, since this is a resourch
institute and our progrtmn are financed through grants and no
funds or: nvailablo for such service.

Thank you

we

shall be pleased to roceive your recommendations.
Sincerely yours,
Fink,
Director

Max

tar/1b

H. D.

�</text>
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                    <text>vw—

July 15, 1964

».r~.~.-

ﬁlm“:

vw—c-n

m»

aw

varux

The Medical Bureau. Inc.
900 North Hiehigsn Avenue

Chicago 11,

Illinois

Attention:

Verona

3. Hamilton, President

Gentlemen:

In response to your

letter of July

1, wherein you requested

ed—

ditionel information regarding the opportunities evailable at
this Institute, we offer the following:

Institute of Psychiatry is the research and training center of the Division of Mental Diseases of Missouri. It
was established in October, 1962, with laboratories and clinical
fseilities for research. At the present time, of 150 beds, we
are utilizing 70 for research purposes. Laboratories are estab—
lished in phsrnscology. psychology, electroencephalography, end
neurology, as well as a computer center for both statistical and
BBC analyses.
There is a specialized psychiatric research library
as a component part of the Institute. Animal facilities are now
being built and will be completed by the end of the year.
At the present time, there are a number of research programs in
progress. These include Lithium as e therapy for mania; the use
of Yohilbine as e precipitant of anxiety and the development of
snti~anxiety agents; relation of EEG patterns and organic factors
in the treatment of therapy resistant psychotics; computer analysis
of the electroencephalogram; the effects of drug withdrawal on the
behavior in the chronically ill; the evaluation of new psychotropic
drugs is part of s national early clinical drug evaluation program.
The Missouri

Institute is planning to expend these programs in the coming
year. We are inviting the collaboration of scientists whose
interests are compatible to our own and who wish an opportunity
such as this institute provides. and are pleased to consider such
The

applications. The opening advertised, and about which you originel~
ly inquired. hes not yet been filled. we will advise you if we do
nets an appointment, and also of any future opportunities sveilsble.

�...

7

1‘:‘w-—~m—

‘rm~‘

the Msdiesl Bureau, Inc.
7-1‘16é
Psgs Two

any-wu-

m'vwrt‘mvfw

I might aid that satisfactory canplstioa of the E.C.F.M.G. cxsa~
instion with sithsr s tsuporsry or permanent curtificsts is prsrsquisits to sppointuant of all candidates from overseas.
Our rsssstch is conductsd sncirsly in tho United Statss, more
specifically. hats at this Instituts.

m

u

It

you b!!! additional questions. plesss direct
sttsntion.

them to

my

Sincsrsly yours,
Fink,
Director

Max

ljb

.

‘
A

_

Hsgr

M.

D.

�June 18, 196‘

The Medical Bureau, Inc.
900 North Michigan Avenue
Chicago 11, Illinois

Attention:

Verona R. Hamilton, President

Gentlemen:
'

for your letter of June 16. we would appreciate your
recounendations of candidates for possible appointment to this

Thank you

institute;

however. the cost of such servicc would be the sole

responsibility of the applicants, since this is a research

institute

and our programs are financed through grants and no
funds are available for such service.

us shell be pleased to receive your recommendations.

Sincerely yours,
Fink,
Director

Max

um»

H. D.

�</text>
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                    <text>WWW

March 26, 1970

Meditoch, Inc.
65 Rogers Street
Cambridge. Mass.

Gentlonon:

and

I have read the report of your automated patient interviewing

clinical laboratory reporting programs for hospitals in the latest

issue of Computerworld, and would bo interested in obtaining any
public information regarding the availability of the programs,
whether their input may be adapted for psychiatric use, and the
charges for programs and/or services.
Many

thanks .

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Rumor 16,1965

Editor

Medical World Haws
7’77
New

'ihird

Avenue
York, New York 10017
"

Bur Sir:

m

A

recent isms of

produced by

mm
WWits.
if
,

was

m». Hem-'1

intemsts and we would bu grateful
distributor or licensee for this

mm:

a.

pmpamtim

Yum report stimlma our
you would tell us who is the
in the United States.

We!

This laboratory is ambushed to assess the cliniml efficacy
we
of new cummds , espeeially in payddmia populatims , anddeswihed
would be. interested in cliniml summit of the W316
.

in your report.

ﬂunk you for your

.
.

«imam.
Sinmly yum ,
Han

Pink, HA).

meessm‘ at Psydziartry

Makp

,

�</text>
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                    <text>r,

many—.p—

January 31, 1967
Continuing Education in
Medicine and Health Sciences 560
'

University of California
San Prmcisco Medical Canton
San Francisco, California 9u122
-

«Awrrry

Gentlemen:

the

The

..

it

to illness, was not possible for me to attend
Sympositm on Ettmmophamaoology dlming the past weekend.
Due

registration receipt is enclosed.

If the policy of theUnivemity is to

mfulfilled mgisu'atims, I

m

such

would. appreciate your doing so.

Thank you for- your cooperation.

Sincerely yours,
Pink, 11.)”).
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>W

New

ADCMD

25. 1979

for Operations (lSlJ)

Department of medicine and Surgery
V100

Washington, D. c. eohso
‘Gentlemen:

I an pleased to write this letter on behalf of Dr. Richard D.
Weiner, M.D., Ph.D., vho is applying for a position as e V.A.
Clinical Investigator. I have known Dr. Weiner for three years,
and in this period, I have come to respect his enthusiasm and his
dedication for research.
Dr. Weiner first came to my attention as e member of the
American Psychiatric Association Teak Force on Convuleive Therapy
when he was asked to serve as a consultant for the electrical
parameters of the ECT process. His report and discussions were
very ugeful and served to expand the final report.which appeared
in 197 .
became acquainted with his work when his application
V.A.
research
for a
grant was reviewed by the Merit Review Board
of which I an a member. Hie application showed a good knowledge
of the ECT process, and reflected his reading. The application
was approved and since then I visited his laboratory. We have
communicated often and I have reed a number of his reports before

I next

they have been published.
Following his

training in electrical engineering at M.I.T.

and

the University of Pennsylvenie in $973, he received his Ph.D. in
neurophysiology and his M.D. from Duke University in 1973. Subsequent

training at Durham in psychiatry and in electroenecephelogrephy
”provided the skills he needs for his present research efforts.

�2.

Mey

25. 1979

is interested
in the convulsive therapy process,~end his skills are directly applicable
to his studies. He has a demonstrated ability to formulate a progrem,to
write the necessary applications well, and to undertake the studies
without additional supervision. He is clearly an independent investigator
with the skills and enthusiasm necessary to establish a V.A. research
In

all,

Dr. Weiner

is a well trained scientist.

He

study.

For these reasons, I

Clinical Investigator.

am

to recommend his appointment as a
pleased
'
Sincerely yours,
Fink. M.D.
th
Professor of Psychiatry

�</text>
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                    <text>,

FYWQV“

v. .—~‘“’Iw'liMN¢WW ,pmwwqw-wm-m new“

~-—-—

.

valw-'

»

wr&lt;.\--.

1m-‘——V.v,vrwr“—r_'rnu«-

--,..—..—_-

an‘Fa-m mymv-.._~wwv_.

vvq -_..._

“Tm.

,7

,7.

_,..,.

U

”w". -_ N

unw-

v'mwwmm-v_"'.rm-v~

‘Yﬂ'

ﬁv‘w'ﬁ“

v.

r

July 22,

1970

Dr. Sarnoff Mednick

Street

2 Perry
New York, New

York 10014

Dear Sarnoff,

Stanley Feldstein recently brought to my attention his
failure to request a honorarium for your visit to us, too long
ago. Please accept my personal apologies for we did not usually

Operate

this

way!

thanks for your lecture, and
continued success of your program.
Many

my

best wishes for the

Sincerely yours,
Max

Fink, 54.0.

Professor of Psychiatry

MF:kt

enc .
.

wnvmem‘

3J4!"

WUJ‘JMFA

‘
A.

4

,

�</text>
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                    <text>May

Mr. Harold Mehling,

Psychiatric Progress

2, 1957

Editor

Street

3 West 57th
New York, New

Deaer.

York 10019

Mehling:

Enclosed is a preprint of our report to the annual
meeting of the American Psychiatric Association, "Digital
Computer Analysis of EEG for Psyclnphamaoology. "
It
would indeed be helpful if you would check with
before
us
making use of this material, for I believe we can
provide
you with additional figures , including glossy prints
which would make the presentation more
'

,
-

satisfactory.

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mchp

�</text>
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                    <text>—.-&lt;-—'w

,

kg
,s

September 5, l967
Mr. Harold Mehling.

Psychiatric Progress
3 west 57th Street
New

York,

New

York

Editor

l00l9

Dear Mr; Mehling:

that
is a

Thank you for your letter of August 29. The presentation
I will be making at Hillside on "Computers and Psychiatry“

of the report published in the recent textbook of
psychiatry puhiished Iy Freedman and Kaplan, Williams and Wilkins.
Additional information is being published in a volume by
Kline and Laska. A copy of this article is enclosed.
summary

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>September 5, l967

Editor
Psychiatric Progress

Mr. Harold Mehling,
3 West 57th Streeti
New York, New York

rt

l0019

~—.‘

v

Dear Mr. Mehling:

-"«'

4”

w;.—

—

'1)in

:‘HNVPv'a-r

avg—39‘:

vwz,

“”""-mlvv'.__

'v

that

Thank you for your letter of August 29. The presentation
I will be making at Hillside on “Computers and Psychiatry”

of the report published in the recent textbook of
psychiatry pubaished Iy Freedman and Kaplan, Milliams and Wilkins.

is

a summary

Additional information is being published in a volume
A copy of this article is enclosed.

Kline and Laska.

Sincerely yours,
Max

-.n-._—.y

.51“-

Hszp

7

’21:.me

Lm-r

WI"

:‘DETTVE‘W:

wwmrm

.qar:

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Fink,

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Professor of Psychiatry

r

by

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                <text>1973 </text>
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                    <text>April 2, 1964

Ex. Roland G. Moinett
4713 Allino Avenue
Tampa, Florida
Dear Mr. Moinott:
Mrs. Anderson, and the copies of your curriculum
rocotd of considot~
vitae, wore Bout to me for reply. I find you:
further.
able interest. and would like to process

Your

latter to

it

is in a study of
positiou at the Institute that is available
Turan Itil.
Dr.
chronic schizophrenia under the direction of
This study is'dodicoted to an unalysio of both biological and
social factors in continued hospitalization of the severe mentally
is an eminent neurologist and psychiatrist. and has
ill. Dr. ltil
planned a series of analyses of brain function of those subjects
and we will undertake
in relation to their behavioral patterns,
We
are aware, however, that
vatiouo trials with new therapies.
many of the treatment failures may be continued hospitalization
because of social factors. These may be historical and relate to
in regular work protho.inability of the subject to participatethe
present time so
grams; or to the problems of the family at
the handicap:
with
that they are unable to intostote this patient

The

they

may

have.

For this rooooo. we are intereotod in having a social wotkor partican. we
oipato in tho program in two spocific areas of work. Inboth
would hopo to have tho analysis of the family patterns,
historical cud ptoocnt, as these may influence the continued who
hoaoitclixntion of tho patient. Secondly, for those patients
may have shown-soon therapeutic effect during our treatment program, we woulo be intarosted in having a wombat of the staffcud tho
specifically involved in contacting the community agencios
families to help the patient bridge the transition from hospitcl
ward to the home and work

setting.

that you could participate in this
like. thereforo. your permission to
write the variouo rofotooo; and would out who: your pro-ant sultry
From.your record. it seems to
ptogram quite well. I ahauld

roqui tenants are .

me

�Mt. Roland G. Helncar:
b~2~6k
Page Two

Thank you vary much

for your inquiry.
Sincerely yours.
Fink,
Director

Max

tit/3b

M. D.

�</text>
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  <item itemId="3569" public="1" featured="0">
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                    <text>7.
[-9
2.

I
5

E

September 4, 1968

§

2

g
a

anagrams?

'
ma"

n—‘uaro

Dr. Harold Meiselas

Associate Commissioner

Treatment and Rehabilitation
Narcotic Addiction Control Commission
l855 Broadway
New York. New York l0023
Dear Dr. Meiselas:
The study program supported by the

New

York

State Narcotic

Control Commission, is focussed on the continuing evaiuation of
the psychopharmacological - rehabilitation treatment model. During
l967, emphasis was placed on an evaluation of dosage range.
tolerance and secondary effects of cyclazocine. naloxone and
tybamate; the role of heroin challenges in the evaluation of
dosage and of treatment; and in establishing a comparison of
methadone and cyclazocine. In addition with USPHS support, we
have evaluated cyclazocine as a clinical antidepressant;
determined its EEG profile in rabbits; and determined the EEG
profile of heroin, cyclazocine, methadone, naloxone and their
‘

.

‘

n-u-m

interactions.

raw-"rmwm,

I'mr‘azu-Pw,

E

E

Copies of reports completed in l967 and to July 1968 are
enclosed, as providing the best summaries available.
These studies are continuing and the present schedule
includes the evaluation of methadone changes in EEG; methadoneheroin interactions; continued evaluation of cyclazocine-methadone;
and a clinical evaluation of naloxone.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.

Mr.

A. M. Freedman
I. B. Schwartz

�August 1968

STUDIES IN OPIATE DEPENDENCE

1967-68

Cyciazocine and Methadone in Narcotic Addiction.
202: 191-194, 1967.

JAMA,

Ciinicai Studies of Cyciazocine in Narcotic Addiction.

J. Pagehiat.,

Amen.
EEG

Effects

of Cyciazocine.

124: 1499-1504, 1968.

Narcotic Antagonist

A

In Koeiia. N. and A. Karczmar (Eds.), Paoceedinga
05

the

ACNP,

1966.

C.

C

Thomas,

Springfield. (in press)

Antagonists in the Treatment of Opiate Dependence.
In Phiiiipson. R.

V.

(Ed.),

Nodenn Taenda

in

Cbmbatting Deng Dependence and Azcoholiam.

Butterworth, London.

(in press)

Intravenous Diacetylmorphine (Heroin) in Studies of Opiate
Dependence.

OLA. Menu.

Naloxone in Opiate Dependence.

Sya.

(in press)

Olin. Phanmacoz. Theaap.

Ciinicai Triai of Cyclazocine in Depression.
Amen.

(in press)

Submitted to

J. Paychzat.

Neuropharmacoiogicai Analysis of Agonistic Actions of Cyciazocine

in Rabbits. Presented at the Soc. 8101. Psychiat., June 1968.
Tybamate in the Treatment of Opiate Dependence.

12-21-67).

(Preiiminary Report -

�</text>
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                    <text>June 17, 1970
Dr. Harold Meiselas

New

York

State Narcotic

Addiction Control Commission

1855 Broadway

New

York, New York 10025

Dear Harold,

regretted your prior committments
that precluded your attending the meeting on Opiate antagonists.
We have been encouraged by the latest editorial by
Philip Abelson
in Science to summarize the proceedings and submit these to his
journal for publication. A cepy is enclosed for your information.
Beth Al Freedman and I

Perhaps

we may

meet soon to review

this data.

Sincerely yours,
Fink, MD.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>Wyn—w

mun-r—

October 26, 1970
Dr. Harold Heiselas
York State Narcotic

New

Addiction Control Commission

1855 Broadway

New

York, New York 10023

Dear Harold,

RE:

Contract 044116

We are actively pursuing the development of a long acting
narcotic antagonist for the prophylaxis and treatment of opiate
dependence. Our clinical studies with naloxone will be reinstituted with new supplies about November 1; the contract with
Food and Drug Research is operational; and we are negotiating

another with Alza Corporation.&gt;
At

4 meeting we became acquainted with another
ﬂ 5050, developed by Beckett and Colman of Hull,

the June

antagonist,
England, for veterinary use. This antagonist is another ”pure"
antagonist, 16»20 times as potent as naloxone in animal trials,
both abroad and at the University of Michigan in studies by

Villareal.

We have received the cooperation of Reckitt and Colman
to undertake human studies. With a permit to import issued by
the FBN, I now have 10 grams M 5050.

Before clinical assays may be done, the FDA requires minimal
animal toxicology data in 2 species, and such tests have not
been done — they are not necessary in veterinary medicine.
have submitted copies of the available data on M 5050
to the FDA, inquiring as to the minimal testing they would accept
for an IND. On the basis of our discussion and my past experience,
they will require testing in 2 species for 6 months with complete
pathology. Such work is done by various university and commercial
laboratories on a contract basis, and usually costs between $20,000
and $40,000, depending on the species studied.
We

We have written to Dr. Louis Harris of the University of
Earth Carolina for his estimate of the FDA requirements and
cooperation in this testing. He is the pharmacologiat who
developed cyclazocine at Sterling—Winthrop and is the most
capable authority in this complex field.

�~2-

Dr. Meiselas

October 26, 1970

1970~71 contract with the
Narcotic Addiction Control Commission, we requested additional

will recall that in our

You

to purchase supplies of neloxone. Fortunately, Endo
Laboratories were persuaded to make 6 Kg naloxone available
sums

at

cost.

no

We

are writing to:

l) Acquaint the

Commission with our progress and thoughts;

Request your review of the enclosed data, and ask that
an opportunity he provided us to meet with Commission representatives
to discuss this program; and,
2)

Enable us to request use of the naloxone supply funds
for a subcontract for animal pharmacology of M 5050, to shorten the
time from animal testing to clinical trial.
3)

Thank you

for your interest.
Sincerely yours,
Vax Fink, M.D.

Professor of Psychiatry

MF:kt

encs:

FDA

Ltr.

M

Submission
L. Harris

5050

reprints

�</text>
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                    <text>1“]
1m,

”nun",

A,-

.Ww—n

A

,.,..,,.-

my 12,

1971

Dr. Harold Meioeles
York State Narcotic Addiction
Control Commission
1855 Broadway
New York, New York 10025
New

Dear Herold,
I am pleased to enclose a draft copy of our interim
report "ZaAlphe-Acetyluethadol and Methadone Maintenance for

Opiate Dependence", dated April 15. We are progressing with
our study, elthough our more recent dosages are slightly higher.
Thank you

for your assistance.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mex

MF:kt

�</text>
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                    <text>\J

I"

ﬂovembcr 22, 1971

Harold Moisolao, 8.0.
Commissioner

Narcotic Addition Control Commission

1855 Broadway
New York, New York 10023
Dear Harold:

I have read the

list

of suggested examinations for methadone
was suggested for research
or as the basis for a more complete examination of methadone treated
patients. As a series of research issues, the suggestions are vague
and seem to reflect a general clinical neurologists' approach to a
problem, without appreciation of the complexity of tne interaction of
opiate dependence, its complications, and methadone.

effects. It is not clear whether this list

(1)

Clinical

exam:

by methadone.

routine medical,

Tue "mental

very detailed and

euphorigenic,

and usually unchanged
status”, of course, can be

is the basis for exhaustive studies of

memory,

perceptual.

Egg,

effects of methadone.

(2)

such a routine EEG is of very limited value. In the
studies that have dissected the EEG effects of methadone,
quantitative measurement: were necessary. These did not
show significant refusal differences and from our past exporionceg such differences are rare witn drugs.

(3)

Ancillary EEG: interesting theoretic speculation, with
little foundation. Despite many studies of drugs, the
AER shows changes only at vary high dosages, and these
have usually been non~contributing to our understanding.

(4)

EEG:

few

Bode:

interlacing, but probably of little relevance to

nothcdone's

mode of action. Again, only chnngcs at very
high doses of drugs or with that: which opecificolly affect

labyrinth: or vestibular nuclll (2.3.. barbiturates,
actuation).

an—

�Harold Mbisolnn, M.D.

Novonhot 22, 1971

similar to 3, 4.

(5)

Blood flow:

(6)

significant test, which is under study in many
laboratottes. Thar: at: at least 3 important issuau:
Rt undo: oinulntod conditions (9.3., drowsy); simple
R.T. and complex R.T. Also, intranodnlity and internodslity issuas are critical. If done preperly, such a
program could be of interest (oopecially simulated R.T.).

(7)

Conduction volocity: as prepared, a test of limited
value. This in a highly complex procedure that may (like
R.T.) warrant intensive study by exports, using sophis~

Rt:

A

ticated methods.

For each item, 1~7, there is
methadone treated aubject.

in each
I

ﬂy

trust those

comments

little

merit as a ”routine" test

are responsive.

If not, please call.

best.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
MF:ig

�</text>
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                    <text>Novcmbcr 22, 1971

ﬁarold Mciselas, H.D.
Commissionor

Narcotic Addition Control Commission
1855 Broadway
York, ﬂew York 10323

New

Dear narold:

I

have road the

list

of Suggested examinations for methadone
was suggested for research
or as the basis for a more complete examination of methadone treatcd
patients. As a caries of research issues, the suggastions are vague
and seem to reflect a general clinical neurologists' approach to a
problem, without appreciation of tho complexity of the interaction of
opiate dependence, its complications, and methadone.

effects. It is not clear whether this list

(1)

Clinical exam: routine medical, and usually unchanged
by methadone. The "mental status”, of course, can be

very detailed and

euphorigunic,

(2)

(3)

(4)

is the basic for exhaustive studies of

memory,

perceptual, 355, effects of methadone.

ouch a routine EEG is of very limited value. In the
studies that have dissected the EEG effects of methadone,
quantitative measurlncnts were necessary. These did not
show significant regional differences and from our past cx~
variance, such differences are rare with drugs.
EEG:

few

Ancillary

interesting theoretic speculation, with
Despite many studies of drugs, the
changes only ct very high dosages, and tho-o
hcvc usually been non-contributing to our understanding.
EEG:

little foundation.
AER shows

20M: interesting, but probably of little relevance to
nothadonc‘s mode of action. Again, only changes at very
high doccc of drugs or with those which specifically affect

labyrinth: or vcstibulor nuclei (0.3., barbiturates,

esthctica).

an~

�</text>
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                    <text>Novonbor 4, 1971

Dr. Harold Moinola

NYS~NACC

1855 Broadway

Now

York,

New

York

Door Harold:

have just completed our conporison of methadone and
l-alpha~acaty1omothadol. The results show nothadol at 80 23., throo
tins: a wook, to ho equivalent to daily nothadono.
We

and

Condidoring the potential saving in diverted nothadono,
3 nor: extensive study ohould haw: a high

in personnel tins,

priority.
(we have

Additional copies for the Commissionor are oncloood.

sent the tort to
My

JAMA

for consideration).

best regards.
Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Mar

Hr:ig
Koo.

�</text>
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              <elementText elementTextId="50982">
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              <elementText elementTextId="50983">
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                  <elementText elementTextId="103793">
                    <text>731: 3.033

W 7.
m. Inwanca

13:le

v.3. Hunter:

a.

Hawks-1:19:31;

1511

K

1973

Sons

Street. m1.

wuhizwbon, 13.8.

20005

Dear Mr. Erlbnum,

Enclosed is the introdmtion to the mime by Martin
Kata. This represents the last. I'm-ml (”went for the volume.
lacking is the list of participants and their affiliatiam. I
have written to all the authors and asked that they sand me.
by return mil, edited titles; mad I have most already in hand.
This submiasion should make possible

a.

better

size of the valume. and the time course of
«that. omtheI will
call you later this week to see where
pumaauon.
we stand.
Sincerely yours,

Mu Fink. Mm.

�</text>
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Kovumher

Dr. Leonard E.

30th, 1972

ﬁaiselaa.

Chairman. 008183,
Surge C, 113.

Bear Doctor Meisalaa,
Enclosed please find copies of tun révised consent
forms for tho prospeativu studies on canndbin. One form

is designated for the acute studies and another in fur the
chronic.
Sincerely yours.

ﬂax Fink. M.D.

Profausor of Psychiatry
MF/ia

Enca.

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Leonard E.

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m Fink, $1.1).

8W:

003138

Boa-mu of

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is

some

54.13.

mating

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t pﬂor
mounting on Ehrch 7th. I! there

CORIHB

intomt-ion that I «:1 supply prior to the

mtinqunbegladtodow.

WI 1.1

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Fcbmm 15th.

1973

Lemma 3. 1401:0101,

90:

Chaim.

W:

mar:

EEG

m m, “.13.
study program

-

$4.1).
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”m

in human mmhophmolm”

31:10:94 am: «epics of mu

W

IND

umber: for

two

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37/13

has .

studies

“W

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                    <text>'Vuxvn-I-

”MEWMW

,7

WV

mw'mmmw

Wis-519m
’

‘hbnm 6th,
to:

Leonard E. Htisclsa, N.D.

FROM:

Mix

BUBJEBT:

Permit for

1973

Fink, H.D.
"EEG

and Psychophugmncology" program

Encloued is a rivisod connent rarm.wt1eh we propasu
to us. in thc study of EEG effects of psychotrogic drugin volunteers. I found the discussion of the Committee
salt useful and have ueetptca each or the recaumsndationn.
1 havn ulna addcd one additional yrutoation, that of un
assurnnne by my research assistant that the participant
nigning the consent did. indeed, rend. 5180083. and lien
in a dioaussion with my tssistant.

If this

consent apotn tha :pprovnl of the Committee,
would uppreoiuto your submitting
tbs-o doeunantt to Er. Pollegrino.
as I

law/13

anal.

trust it will. I

�</text>
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                    <text>731-622

April 16th, 1973

qu.J.mn&amp;nnq
Cantrtcting Otricer,

hr

mu

char-was

Chief, Centractl Minagcmnnm Bastion.
Grant: anﬂ Contrnnta Manngannat Branch,
Hational Institu$e of thtal Ecalth,
5600 Fishers Lane,
Rockrille. Maryland 26852.

VW4"W¢"L'1‘/“"I"

Dear Mr. Grndvell,
:w-‘m'quwwvr

HQ have been notified by taluphano by Mr. Jack
Johanna of your office thax aur reqnsnt far an cxtansion
at HEM h2~70~98 for six manths bawbnd June 25, 1973 has
been approved by the pragrnm review toam, and that it is
your Intent to fund this request. Mr. Johnson indicated
thut a formal artension will reqnire some time to:
processing.‘but assured us that we should proaoed on the
assumption that our raqnast will be ”substantially" approved
there being same itaau which arc subjact to nagotiation.

-

the assumption that this assurance in substantially
are notifying the subcontractor. Professor C.
steflnis of thc Untvernity of Athuns to proaeed with the
special studies (nusaasnant of withdruvll otteats) outlined
in that request.
0n

correct,
A

vmv

um

If this

asauranne

of tha coumnniention of
natify ma promptly.

is in Jeoparay. or our interpratation
is in error, pleas:

Mr. Johnson

It is also my understanding that the praparationn for
the unsatiationa for the axtennion will require 3 to 5 vuoks.
I trust thane conelnsions nrc aorreet.
sincerely yours,
mmmwcwnnnmm

Max Fink, M.D.
Professor of Psychiatry

MF/iJ

ea. Costa: stefanis, K.D.

�</text>
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                    <text>nib-607

‘pril

W

M6518!!!”

y.

Program Head,

2nd. 1973

HOD. .

Early Clinical Drug Evoluntion Unit.
Psychophamoology Research Branch.
Rational Institute of Mental Health.
5600 Fishers Leno,

nockvillo,

Maryland 20852.

Dear Tom,
Enclosed is a short abstract of the presentation
which I plan to make at the May 25th annual mom meeting.

I think the program is fine. Should it be ponible.
be batter accepted no
following that of David Nargulen. rather than following
the two teohniool, statistical. highly sophisticated report:

I think the presentation vould

of

Mike Free and John

Overall.

Sincerely yours.

Mix Fink, M.D.
Bxetutivu Direotor

m/1.1
’

C

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                    <text>December 6, 1971

Dr.

Christer Meissner

Ciba-Geigy

AG

Basel, Switzerland
Dear Dr. Meissner:

Enclosed is a copy of my report to the World Congress
of Psychiatry, and an earlier report which describes more fully
our latest findings. I trust these will be helpful.
and

I

Our studies of GP—41299 will be completed by February,
hope these will be interesting.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Ming
Ehc.

�</text>
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                    <text>SepteMber 13, 197h

William G. Clark, Ph.D., Chief
Veterans Administration Hospital
Psychopharmacology Research Ldboratory
Sepulveda, California 913h3
Dear

Bill:

Enclosed are the references which you requested for the
updating of your volume.
former

I regret the delay, but your letter was sent to
Institution and took some time in getting here.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

Enclosure

'

my

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                    <text>Ma

April 3, 1993

Barbara Melisch, M.D.
Universitatsklinik fiJr Psychiatrie
Auenbruggerplatz 22

A-8036 GRAZ, Austria

Dear Dr. Melisch,
For reasons that are outside our control, regret to say that we are
unable to accept a Fellow in ECT for the coming year.
I

Thank you for your interest, and my regards.
My regards.

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

and Neurology

�Post-It" brand fax transmittal memo 7671 lilo! pages
T°
Fm“ Mai): Fr
32' E). HEusui

rt

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mt

Co.

Co.

Dept.

Phone #

szxv43~31¢-38§-55I6

Fax #

5M: KM.

8604

“Ca/oy—
February 13, 1993
Barbara Melisch, M.D.
Universitatsklinik fiJr Psychiatrie

Auenbruggerplatz 22
A-8036 GRAZ, Austria
Dear Dr. Melisch,

This letter is in response to your inquiry regarding
a fellowship at this
University for 1993-1994. Ordinarily, our committees have their budgest
assigned and have made their decision by this date. This year, however, the
University budgets have not yet been assigned, and i am writing to tell
you that
a ﬁnal decision will not be made until the end of April.
I

difficult.

recognize that such a delay is frustrating and makes any planning

My

regards.
Sincerely yours,
Max Fink, MD.
Professor of Psuchiatry

�August 26, 1992
Barbara Melisch, M.D.
Universitatsklinik fUr Psychiatrie
Auenbruggerplatz 22
A-8036 GRAZ, Austria
Dear Dr. Melisch,
We received your letter of application for a fellowship in psychiatry and
the supporting material. Thank you.

The file is as complete for the present as we need. The Fellowship
committee will consider the application in the late winter and announcements of
awards are made in early February for the next academic year which begins in
July, 1993.

Before the end of this year, you will receive additional inquiries and
advice about your application for a suitable visa from our Training Office.
understand that such an application will have to be made by yourself in Austria.
I

look forward to seeing you in Munich. Hopefully, will have more
information at that time.
I

I

.

'

Have a good holiday.

Sincerely yours,
Max Fink, MD.

Professor of Psuchiatry

the

f’/

l/ 5

”4/

/

a)

'

I/ﬂ/[

�August 26, 1992
Barbara Melisch, M.D.
Universitatsklinik ftir Psychiatrie
Auenbruggerplatz 22
A-8036 GRAZ, Austria

Dear Dr. Melisch,
We received your letter of application for a fellowship in psychiatry and
the supporting material. Thank you.

The file is as complete for the present as we need. The Fellowship
committee will consider the application in the late winter and announcements of
awards are made in early February for the next academic year which begins in

July, 1993.

Before the end of this year, you will receive additional inquiries and
advice about your application for a suitable visa from our Training Office.
understand that such an application will have to be made by yourself in Austria.
I

look forward to seeing you in Munich. Hopefully, will have more
information at that time.
I

I

Have a good holiday.

Sincerely yours,
Max Fink, MD.

Professor of Psuchiatry

wW
-

( 4% M

//

-

_

%

-—

/r/

Llag‘e‘r’ ’z.

(0?” FM”

/

�July 3, 1992

Barbara Melisch, M.D.
Universitatsklinik fiJr Psychiatrie
Auenbruggerplatz 22
A-8036 GRAZ, Austria
Dear Dr. Melisch,
Thank you for your inquiry about research opportunities in our
Department. Each year we offer fellowships to qualified candidates in
consultation &amp; liaison, sleep disorders, ECT and psychopharmacology, and
child psychiatry. If you specifically wish to work with my team, the fellowship
ECT and psychopharmacology would be appropriate.

in

Please send me a new letter requesting consideration for a specific
fellowship, effective July 1, 1993, describing what experience you seek. if
possible (and know it is difficult), the note should specify why you seek U.S.
training. [e.g., to undertake a specific research project; or for general research
experience to allow you to return to Austria and an academic career; or for
greater exposure to US. clinical experience; etc. If you have a specific project in
mind, would you include a few paragraphs describing the project?]
I

We will also need the following information:
-

curriculum vitae
copy of ECFMG and any other certificates of training in English
copy of certificate of any post-M.D.training.

Zapotocky (or other senior psychiatrist) would describe
your education and experience. It would be particularly helpful if the letter would
suggest what expectations are held for the additional training.
It

would be useful

if

Dr.

This reads like a lot to do but
application for a fellowship.
My

regards to

Dr.

it will

be useful to support your

Zapotocky.
Sincerely yours,
Max Fink, MD.

PRofessor of Psuchiatry

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                    <text>1-.

May

51”“

5, 1978

Nancy K. Hello, Ph.D.
McLean Hospital

Belmont, Massachusetts

Ref: Jovan Someon,

Dear Nancy,
Simeon

to

I

am

M.D.

pleased to recommend the 'promotion' of Dr. Jovan
of the ACNP.

Member

I have

known

of Jovan's work since 1965

when he came

to

at the Missouri Institute of Psychiatry. His early training
was dedicated to the problems of adult psychopharmacology and he
carried out numerous studies of the clinical and laboratory effects
of compounds. His interests soon focussed on the problems of
join

me

pediatric psychopharmacology and since 1970, his emphasis has been
in the assessment of the effects of compounds in children.
He

has made some important methodologic additions to

the usual assessment, defining the importance of videotape recording
and analysis, and of the evoked potential in assessing drug effects.
His recent interest has been in the effects of cromolyn sodium on
hyperkinesis-— an innovative and novel approach to the problem of
the definition and treatment of this commpn disorder.
He has assumed responsibility for the clinical and
research programs in pediatric psyuhopharmacology in Ottawa. In a
recent visit to his center, I was impressed with the variety of
studies underway, and the enthusiasm and training of his associates.
His contributions to date are listed in his c.v.; his future contributions

should be most helpful in this difficult
and I recommend him highly for promotion

area of psychopharmacology,
to Membership status.

Sincerely yours,
2.
v

.r.

,a-VWl-D-Ilmr‘ﬂtlinw

Pink, M.D.
Professor of Psychiatry
Max

Fellow,

ACNP

�</text>
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                    <text>August h , 1978
Nancy K. Hello, Ph.D.
McLean Hospital

Belmont, Massachusetts

Re: William E. PAIN, M.D.

Dear Nancy,

I an pleased to recommend the.proeotion of Dr. Willi-urban
fron.Menber to Fellow of the American College of Neuropeychophernecology.
I heve known of Ed's work since his early publications with Jenowsky
and Davis on a wide range of subsects in psychopharmacology. More
recently, I have participated in a number of conferences which he has
organized and hove come to appreciate his skill as an editor and administrator in getting volumes on the psychopathology end treatment of
different psychiatric states. I particularly appreciated his

volume

on gerentopsychiatry.

is e capable researcher. whose work over the past
reliable. He is clearly among the beet of the young
ho's 'young’ !)
investigetors (to think that one would call someone in theirrecommend
and his contributions are sufficiently well established to
Ed

decade has been
him

for promotion to Fellouohip in the

I an pleased to

commend

ACHP.

his promotion to the College.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Fellow,

ACNP, CIR?

�</text>
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                    <text>December 14, 1987
Herbert Y. Meltzer, MD.
Department of Psychiatry
Case Western Reserve University School of Medicine
2040 Abington Road

Cleveland, Ohio

#14122

Dear Herb,
The letter by Lieber in the American Journal of Psychiatry seems to have
been a spontaneous letter, not submitted in response to an article in the Journal. It
looks like an old-fashioned testimonial. For my part, it argues for a complex
polypharmacy whose worth is not known but whose risks are formidable.

have written to Morry Lipton as attached; and am sending you a copy as
one of the two established psychopharmacologistson the Editorial Board. Should
the Journal not publish a disclaimer noting that the recommended methodology is
.‘LOE substantiated either by published studies or established practice?
I

In the past few years, I have been asked by lawyers to review the records
of patients treated by polypharmacy; patients who have had significant damage

(including two cases of death) which could be ascribed to such practice. One well
established practitioner gave up his practice when faced with charges of abuse of
practice largely due to polypharmacy. Should We not respond to the Lieber letter?
This is another small annoyance, like the arguments of Johnstone and
Crow, which we heard in San Juan.
My

best regards.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>June

3, 1992

Herbert Meltzer, MD.
Department of Psychiatry
Case Western Reserve Medical School
2040 Abington Road
Cleveland OH 44106
Dear Herb,
Your telephone call about my letter to the APA regarding Dr. Orne led
me to my files. enclose a copy of my letter to Dr. Sabshin and his office’ reply.
That is the extent of my involvement, which followed on the public presentation
of what was alleged to be Dr. Orne’s release of confidential tapes from
psychotherapy sessions after the death of a patient.
I

do not know how my name is associated as a lead name in a
complaint. called Dr. Sabshin’s office and was told that my letter was one of
many that had been received and that had been forwarded to the Psychiatric
Physicians of Pennsylvania.
1

I

The matter is not personal, either with regard to Dr. Orne or the
author to whom he released the tapes.
I

trust this information may be helpful. My best regards.
Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="104686">
                    <text>May

To

the

Members

At

20, 1965

of the Foundation:

the last meeting of the Board, the

More

requested

momtmitytoaeemofthempwtepreperedbytm
of
I am
emloee
staff of the
three
Institute.
pleased to
the latest published studies which were completed last
summer. I m mloeing a report written by Dr. Ulntt,

mobyDr. Itil,mdmebynr.

Gerehm.

You will note that these reports failed to give audit
to the support of the Psychiatric Research medatim. This
oversight has now been mooted, and Dr. Ulett, as Chaim
of the Department, has recently instructed all the femur
appointees of the Fundetion in the proper form to be used
in future publications.

Oonomntly, I an expedmnting with e pan-print
will provide for the pmper credit to the
Emulation and its swport at the time when documts are
submitted for publication. As soon as this form is

model much

crystallized. I plea to bring

it before the Board.

Ilookfomerdtohevingyoujoinusonow
Riwrboetl’artyondml.
Sincerely yours.
Fink, Md).
Executive Director
Max

Mszm

Enclosures

�</text>
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                    <text>May

31.

1971;

Alice A. Leeds, M. D.
Chief, International Rafaranea Center
rbr Information an Psychotropic Drugs
Paychopharmaeology Research Branch

National Inatltuto of Mental Koalth
5600 Fiahara Lana
Rockvilla, Maryland 20852
Dear Alice:

‘
.

When I completed the presentation of ”Etfacta of ACTH
Peptidas on Memory and Brain Function", at the ECDEU Meetings,
the discussion was quite enthuaastic. Thu next day, the presen—
tations on TRY, another polypaptida. were also supported.

Rather than send you an abstract as you requasted tbr
PaychoPharmaeology Bulletin, I am sending tha complete paper.
would be of interest
Should yon.w1ah to publish thin, I believa

the

to the readars. If you feel

it is too

abstract of the length you roquaat.
my

it

long, I will prepare an

beat regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure

�</text>
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                  <elementText elementTextId="104505">
                    <text>e-v m4 -zm“_.,_,....rm..,...—. u
w

,__

w“.— vuq,&lt;'u—~.’mww.—rr4

w

.

Y

., u,

v.~uw,ww.~vy‘m- mun.”

w

“amuww

-

r

,

w»

.

:.

“mm.“ .‘___.,,,_ _--.« up”;

,

‘.,-—r,-.,.\

January 19, 1968

mumof Psychiatry
mem
Harvard radical 801ml
Ir.

Jack

H.

Nahum:

Wnaetts
Fruit Street W1 mm

WW
Marl». Wm:
Boston 1n.

Itgimmwtplumtomymadmftaopy
mm ”m Effects of W1 Aloulnl"
M is the
of addictingdmgs
thirdmtinn afar-vim afEmaffwts

of the

This
mmmmluodbymofnymm.
miummmadupartofmmdypmgmmmw

WWWHRHMIWMWIM
.fomammbarofyurs.
I trust this will intmst you.

be appreciated.

Your

mat: will

Simmly yams.

HP: jh

Fink. M. D.
m
Professor of Psychiatry

.—»

v..-,-

.v

u

w

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V

�</text>
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January 1, 1970
Dr.

J.

Mondale, M.B., M.D.

Depression Research Unit

V.A.

hospital

University and Woodland Aves.
Philadelphia, Pa. 1910é
Deer Joe,

It was kind of you to invite my participation in your
volume, "Textbook of Biological Psychiatry", and I am pleased to accept.
An I read the list of prospective titles. I so surprised that you
see the EEG as a companion piece to the many biochemical essays planned
for the volume, and I hope that I will be able to accomplish the mission
in a satisfactory fashion.

I presume you wish an outline and you will not a reedonahle
deadline for the final manuscript.
You should know that I am working on e cimilar section for
the Textbook of Psychiatry, 2d edition by Freedman and Keplen. I have
diocuased your outline with Dr. Freedman, and we both agree that it is
possible to make the presentations sufficiently distinct as not to cause
either you or him any embarrassment.
My

m

best wishes for

a successful 1970.

-,
Lyra-

r"

Sincerely yours,

m-mvnumu'v

“If“?

Fink, M.D.
Professor of Psychiatry
Mex

:rpxmw'w.‘

No-

4:
I,"

mf/

9.9.

Would you be so kind as to post the enclosed announcemoot of the
1970 APPA meeting on some suitable bulletin board at your hospital ?
Bony thanks.

�</text>
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January 8, 1971
Dr.

J.

Mandela

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and woodland Aves.
Philadelphia, Pennsylvania 1910&amp;
Dear Joe,

Enclosed are two copies of

contribution, "EEG and Clinical
Psychiatry", for the textbook. I have elected not to include a
number of EEG figures, since these are ably reproduced at greater
length in the citations. If, however, you believe the report may
be improved by examples, I will submit some representative figures.
There

is

a

my

single table. reproduced

from my 1969

report.

If

acceptable. I will write to the publisher for permission to reproduce.
your

I trust the report is useful,
invitation and your patience.

of this volume.

for
best wishes for the success

and I thank you once again
my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
one o

--

7-

-

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&gt;~;wv¢:-wr1thnz~&lt; : "1“”"“"\'.'I"WW"~‘¥NGW'Y'VWWAWC

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February 1, 1971

-"w-WWTW’”"’WWWWWF"K1'IWW’W—w

Dr.

J.

Mbndels

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and Woodland Aves.
Philadelphia, Pennsylvania 191I4
Dear Joe,

Earlier this month I submitted two copies of a contribution
One of my associates has reviewed
to EEG and Clinical Psychiatry.
the text and found a number of small errors. I have corrected
these and to avoid the expenditures of corrections in galley, please
replace the two copies in your hands with the two enclosed.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
awn”

«.

'32-

n

Mszt
enc. (2)

~~

�</text>
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                    <text>.ﬂ

mun-x

~va

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W

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-----

W'.‘W&gt;'~-~

"'e-r-E-I-v1a-rusu

»r£'n'-‘Mn-.1rtr/!"~Y‘

-,"~—"#'ﬂ“r

March 22, 1971

Dr.

J.

Mandela

c/o V.A. Hoopital
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Joe,

Dear

Enclosed is a revised chapter, "The Electroencephalogram in
Clinical Psychiatry”. Your comments were cogent, and I trust I
made the changes in a useful fashion.
but

(3)

Table I has been revised.

this simplified version

It

has been published elsewhere,

can be published.

"0-.-

‘
“a.

w
&lt;
..

7-».

VMI'WFW

r,"

a'—,

"W

(11) The controversial sections on pages 9 and 10 are deleted.
There are useful for the specialist, but may have no place in a

textbook.

(14) Unfortunately, there is no good data on the
ﬁrDopa or PCPA on the EEG, and these must be obtained.

effects of

mlwmbé"

Thanks again

«r

for the excellent editing.
Sincerely yours,

WIMWVYH'mwmarAme'

Fink, M.D.
Professor of Psychiatry
Max

1n

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7m.

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‘EV’IIWIYSHW‘W

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                    <text>March 22, 1971

J.

Mandela
V.A.
Hoepital
c/o
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Dr.

Dear

Joe,

a revised chapter, "The Electroencephalogran in
Clinical Psychiatry". Your comments were cogent, and I trust I
made the changes in a useful fashion.
Enclosed

(3)

but this

is

has been revised. It has been published elsewhere,
sinplified version can be published.
Table

1

controversial sections on pages 9 and 10 are indeleted.
a
These are useful for the specialist, but may have no place
(11)

The

textbook.

Unfortunately, there is no good data on the effects of
or PCPA on the EEG, and these must be obtained.

(14)

£~Dopa

Thanks again

for the excellent editing.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>August
Dr. Joe Mandela
Depu'tnmnt of Psychiatry
Univmity of Permsylvania

Philmelphia, Pmylvania

114

, 1967

19104

Dear Dr. Mandela:

I have juat read your latest report on “The Pmdiction
Response to Blectmccnvulsive Therapy," in the Arne/view
06 Paydvéauy. I {mm the mpwt of cmsidemble interest

of

Jam

it

because
dazmnstmted once again the predictive mam of the
psydxopatYnlogical syndmmc in the treatment response.
We are umiertaking amther study of electmcmvulsive
treatment and I would be grateful for reprints of the three
earlim‘ articles (I: this subject which appeared in the
Jeanna. 05 my
.

Wk

'

‘

Incidentally, I enjoyed am short discussion vary much
during my mount visit to North Carolina and mid like to
take this opportunity to wish yw the beat of research climates

in Hailaddphia;

Sincerely yours
Max

Firk,

M.D.

_.

Professor of Psychiatry

Wzm

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                    <text>September 6, 1972
Joseph Mendels, M.D.

V.A.

Hospital

Dear

Jot,

Philadelphia, Pa.

no

errors

I

Your publisher has done an

excellent

joh—-

for I

have found

I have sent the sheets for the indexer, as requested.

is

one suggestion. For me, the "M.D." is a part of
my name. I think it is reverse snobbery, an insincere attempt at some
egalitarianism or democracy to list authors names without their
principal degrees. I would ask that my name be listed on page 331

There

as "Max Fink, H.D.".

It is also

embarrassing to me, for the type to be so large
for the name. Perhaps, in resetting the line, the linotypist could
use a typeface of the same size as the text, like 10 point ?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

P.S. Since the text will appear late in 1972, I would appreciate
my affiliations as:
Professor of Psycyiatry, Health Sciences Center,
State University of New York at Stony Brook; and
Adjunct Professor, New York Medical College.

�</text>
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