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                    <text>February 27. 1964

Dr. Juan: Hargnriaon

Institute of Psychiatry

The Mandalay
Denmark E111

London,

England

8.3.

Hospital
5

Dear Jim:

I am planned to enclose a cepy of our first Innual report. It
has been largely thrangh the support of our many fricnds both
her. and abroad that we hava bean able to develop-these labora»
aortas. I hope that in the next year we will be able to get
lama research done that will do credit to the efforts in

davaloping this organizaaian.
Hy

personal thanks for your help.
Sincerely yours.
Fink,
Director
Max

I

HIP/1b

Ens.

M.D.

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                    <text>January 2. 1964

Jams

H.

Margerism,

H. D.

Institute ’of Psychiatry

Departmnt of Expertimntal Neurolcw
mudshy Hospital

The

Hill
Imam, 3.2:. 5. England

Denmark

‘

Dear Jams:

I wmld be plead if you would accept
ﬂuenclosed cheek forymmmy «Moss dwingtho past few
Emma on 239le of the mssmri Institute of Psychiatry. It has
men a good year, and with the help of many trim, the Institute
Happy New Year!

tin.

is mu operational.

Last year at this
them were fawn.a mamhem of the staff, including melf. Today, than are three senior
scientists, four associates. and a research staff of twenty. (In
68. It has bun an exciting begiming.
the wards, we. have a
and for your help, my thanks.

comth

My

best regards.
Sincerely yams,
Max

Pink,

Dixwtcm‘

Wanda
ﬁne. 1

M.

D.

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                    <text>I/

July 17, 1966
Jones E. Margerison, M. D.
Department of Experimental Neurology

Institute of Psychiatry

The Mnudsley
Denmark Hill

London,

Hospital

5.3. 5, England

Dear Jim:

thinga have happened these past four months since I last
wrote. and l em‘Wtiting now to tell you that I look forward to
visiting with you in London. My plane are to mivn in London
eagly Wednesday. August2§, from Paris George Ulett will be
”arriving in London that night .na unfortunately, we both have
reservationa to go to Raweaatla to visit Martin Roth Thursday
London the 29th and
evening, August 27. I plan to ho pm
'30th, before going on to Birmingham.
J/
//
I would be delighted to spend Rednesday afternoon and Thursday
morning with you, and will anoapt your hospitality to: Rodnesday
evening if Sheiln is willing to care for a "bachelor“ for that
evaning.
Many

in

Unless our present plans ohange very much, we are vietins of
the peculiar air traffic schedules which provide special rates
for twenty-one day trips. For months. Mattha and I have resented
this. and have tried to find an alternate for her to spend a
‘longer period in Europa so that she tonld include a visit to
London in this trip. However, because Jonathan‘is going with us
and because all of us wanted to visit Israel this year, we are
going to leave New York on the 4th, and plan to spend ten days or
longer in that country. For this reason (unless I can find an
additional $300 between now and than). Hertha will bu leaving the
Continent on August 26. George and his wife are involved in the
same cartel squeeze. so that he will be alone in England from the
27th on.
Since you

last wrote,

Andy Don and

Betty joined our

stafi.

En

la

a delightful young man. energetic and bright. and.inexpetienoed.
Your evaluation was exactly right, and I am glad he joined our
staff. bananas ho ia working very well with me and with Taran.

�Dr. Hargorison

7«l7~6£
Page Tho

Our many programs. including computer aunlyaio of EEG, drug

evaluation atudy of chronic schizophronics, etc.. all loan
to be in the data colloction phase. Within the last month
I soon to have con: out of a cloud of administrative detail
and find that I dovoto more and more time to the laboratory
and to reading than I had in the previous year and a half.

have boon through many problems. but now the Inatituto
soon: to be operational. moderately wall equipped, and quite
well staffad. I'am looking forward to discussing your work
and viuiting your laboratory, and hopefully, meeting some
of your friends and co—workors next month.
we

I

also taking the liberty of giving your home address to
sooratary, with the suggestion that she (11 she want: to
reach me in London) tend my mail to your home.
am

my
my

best regards to Sheila.
Sincerely yours,
Fink,
Diractor

Max

MFIjb

M.

D.

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                    <text>Saptaﬁbar 14, 1966

Janos H. Hargariaon, M. D.
Department of Expsrimontal neurology

Institute of 2sychiatry

The Mandalay
Denmark Hill

London,

Hospital

3.3. 5, England

Dear Jim:

past two weeks. since laaving you, have been exceptionally
thought provoking. my visit with you was a stimulating one, to
say the least. for I think you made clear tho importanto of
oraativa work for people 11kt ourselves. While I have had many
doubts during this year ragarding the significance of what I
may hava accomplished since coming to lissouri, the clarity
The

with which you criticized my work made on fuel that I had little
recourse but to go back to tbs laboratory immediatoly and perhaps
justify the axistoncc of this laboratory, not by the work of
others. but by my own. Perhaps this can bc done in the scat yoar,
and I look forward to matting with you at coma near future time
with more data and laws: administrative explanations.
Tho mastinsa in Birmingham ware fair from our point of View. us
missed tho presents of many-of tho slottroancaphalographars and
nourophysiologiats who hava had oxpariancc with quantitative EEG,
drugs. and clinical populations. ‘Ihors were only a few of us who
could carry on the discussions and as wo loft. Turns. George and
was sand for a full scale matting of people
l {alt that there
intarsstad in EEG quantification and psychiatric problems.
Indeed. we thought we would like to suggest it to you ~ since
London is such a central-location, that you might try to organize
a wasting. perhaps undar the aegis of the EEG Society, of people
liks yoursslf. Laidlaw. Shagass, your friend Harding, and others
who may ba better known to you whoaa interest in EEquuantification
may oaks it possible to discuss not only the methods. but thair

ralation to clinical bahavior.

While

in

Birmingham, Enron and

-

I visited Graham Harding at the
Ha is a delightful follow. and

Collaga for Advanced Technology.

it was

a most rewarding

visit.

Ha know

sons of the people in tho

�,Dr. Herserison
9-14~6A

Page The

United States who are carrying out work similar to

his.

and we

spent s most pleasant two hours. I knew little of his application
of Isndell' s concordance but would like to see how this may be
related to our own work.

Perhaps most important is the pleasant visit that George and I had
with John Dawson. we spent a most pleasant few hours discussing his
work and at the end of which. with your kind permission, I asked
whether he would be interested in coming to our laboratories. He
seid he would like to consider it. so we tried to arrange for another
meeting just before we left England. As you may already know. we had
great diffioulty in getting to Rnnwsll and it seemed most expedient
to here San Gershon, our pherneeologist. visit withhhtm. Sen ceme‘
bank to the States with a very fine report and I an.writing to Dawson.
encouraging him to consider an appointment with us., Our procedure in
processing such appointments at the present time is somewhat simpler
than two yeers ago since the relationships with other agencies have
been olerified; however. I would like very much to have s letter of
referents from you concerning the extent of your collaboration. your
estimate of his abilities as a bio-chemist. and any other comments
you wish to make which I can use to present to the Dean and the ep~
propriate committees of the University.
.

with regard to a major portion of our discussion concerning your own
future, I on sure, indeed I so confident, that you must and will continue your research programs even if you have to devote s good part
of your energies to becoming e "£amous nan". Good luck. and my many
thanks to Sheila for her hospitality and dinner. Jonathan extends
his thanks to hell for the cricket ball. which has become a center~
piece in his bookcase and I hope an object that we will use this
coming weekend.

my

best regards.
Sincerely yours.
Mex

Fink.

Director

Miljb

M. D.

�</text>
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                    <text>Deceasber 22 , 1965

Wt

Dr. Jams H.

Morison

of Clinical Hemophysiology

mittington Hospital
Highgate Wing
W151 Park Hill
[atom

N. 19, England

Dear Jim,

It is

kind of you to write and to send me ydur reprints.
criticism that the studies we have publist are weak became
of the led: of biomemietry is something with which I canplctely

Your

moor. Ywmstkmwthat forthepastthmeandehalfyem
I have tried (vim enemas) to obtain the oollabomtim of a
clinical neurodxemist.

The work with m. Itil mad the meter facility are both
fmotioning very well. I believe we have been rare productive
in the past six months than any pmimxs period in the Inetitute's
history. Indeed, I have delayed answering your letter because
I have been may many weeks studying at other units and presenting
our data at various meetings. There is much that we have learned
about molinergic mechmism end about psychotropic drugs. I
believe that changes in the electroencephalogram do reflect the
chmges in biodxomistry and that these indices are as sensitive
as the early photmtem. While they were very gross, they did
provide spproximtima which were the bases for- many of the
clinical ideas in medicine today. A frimd of yours, Dr. Semfitinides,
visited the Institute loot week and pmemted some of his observations
on tonpoml lobe epilepsy. He apparently has joined the institution
in Oklahoma City and seemed quite pleased with his opportmity and
especially that he was able to leave England.

this trip was too short to permit
mtioetostopcver-inlmdon ThemeeﬁngsinSelzbmgwem
We

did miss you in Vienna and

especially good and I mt enjoyed the msmtetions by m. Beditereva,
reported on the quentifioation mthods in the Soviet Union.

who

Memquitepodmdlhopethetlwillheveanoppommity
and
this emr- to attend the International Psychology Meetings
perhaps get to know mm about their techniques.
By now

you probably loam

that having established these laboratories

Immadytomveagain. Ihavebeeninvitedmdhaveeooeptedm
appointmmt as Professor of Psycﬁiatry at the New York Medical
College. While it will mean that I will have to work very hard
to establish a third laboratory. I believe that I can

Midas
my 1.

time and with

w

do so in
with
web lees
present experiences,

�Dr. Huger-ism

~2-

December 22, 1965

Wjommeinamdingyoumdmihour-MNgu-damd

ourwishos faraVorylrIappyﬂchm.

sincerely yours ,
Max

Fink,

H.113.

Professor of Paydmiatry

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                    <text>July

20 , 1967

Dr. Murray B. Margulies

Supervising Psychiatrist

Civierenter Clinic, Inc.
an Willoughby

Brooklyn,

New

Street

York 11201

Dear Dr. Margulies:
Enclosed are two preprints which describe the present
status of our cyclazocina experiences. we are now developing
more definitive cyclazocine —:methadone comparisan studies and
these may provide information for a subsequent report.

Sincerely yours,
Max Fink, M.D.
FTUféSBOP of Psychiatry

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                    <text>June 17. 1968
Executive Secretary
Marihuana Advisory committee
Center for Studies of Narcotic and
Drug Abuse

National Institute of Mental Health
USPHS~BHEW

5454 Wisconsin Avenue
Chevy Chase. Maryland 20203

Dear

Sir:

Enclosed are twenty~£ive copies of the documents
which you have requested in order to provide us with
supplies of marihuana and tetrahydrocannabinol for

investigational purposes.
1a)

b)
c)
d)

See protocol attached
See curriculum vitae
See protocol
Baa

~
~

Exhibit
Exhibit

1
2

protocol

For marihuana trial: we will require approximately
one ounce for every ten experiments and would like to request
four ounces an an initial aupply.
2)

is

For tetrahydrocannabinol we understand that 20

an average dose and
3)

for

20

trials

we would

roquiro

Both marihuana and tetrahydrocannabinol

stored in an approved narcotic safe at
Eighth Floor.

Room 42A.

recommendations.

Documentation

is

4)

Curriculum vitae

5)

Institutional setting:
a)

5

East

will be
Street,

102nd

will follow your

oncloaad.

Department of Paychia try. new York medical
College and Hetropolitan Hospital Medical

Center.

mg

400 mg.

�b)

This project has been approved by the
Chairman of the Depertoent of Psychiatry.
the Research Committee of the New York
Medical College-Metropolitan Hospital
Medical Center and the Commissioner of
Hospitals of the city of new York.
See letter. marked Exhibit 3. 4 and 5.

6o)

b)
3;

IHD 4724

-

EXhibit 6

See Exhibit 5 - Letter from Rosearch Committee.
Consent form ettedhed ~ Exhibit 7.
Merihuene Tax Stomp ~ Exhibit 8.

Sincerely yours.
Max

Fink. M.D.

Professor of Psychiatry

Wakp

enclosures

�</text>
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                    <text>V..

”new

...,

A,

v.._,y..

g.—

72.2“”er

’1’”.me

vr

January 18 , 1967
Mr. Gerard A. Marini

Medical Center Representative
Roche Laboratories
75% 8. Ocean Avenue
Preepor't, New York

Dear- Mr. Mar-ini:

Thank you very
discussed with you,

the Mental

Hygiene

visit on January

much for your
we are undertaking

13. As I
a teaching program in

Clinic for psychiatric residents.

it

would be very
Since Librium is a oarmonly used drug,
and
had
placebo available
helpful if we
a supply of the drug
so that individual patient treatnent schedules can be modified
to the patient's best interest. I would be grateful if you
would make available a supply of 5,000 tablets, 10 mg Librium
and an equal amount of placebos.

Thank you very much.
Sﬂloerely ywrs,
Fink, M.D.
Professor of Psychiatry

Max

and Clinical Director
MF:kp

�</text>
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                    <text>February 13, 1967
Judge Merino
Bergen County Court
Newark, New

Jersey

Dear Judge Merino:

Last month I participated in the review of the case of
Trantino. Among the questions which you raised was
one regarding the interaction of the psychiatric drugs and
alcohol. Enclosed is but one of the recent reports which
show that the interaction between psychiatric drugs and
alcohol is high.
Thomas

You will note that this study has been done in animals,
but similar effects are likely to occur in man under the
same

conditions.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>-

, 'ﬁu’i‘v

.«

-vvszr—

.

7m. -1vwwm-"‘

~x~

.

4-3-47. ,»

.n

~"n'.‘.w,'_

,

"r vwom-hmr .79—

..

mu‘lmu' .w—ngew wqw—g

.

a»

7M-WK’»;JIL1IM'-

as:

aw r vm: fr:-

,

w 1M2“? N"

rat- luv

7,”...

Novenber 12, 1970
Dr. G.

Harjsrrison

Associate Professor
University of Saskatchewan
Department of Psychiatry
Saskatoon, Canada

Dear Gordon,

I

am

pleased to enclose a draft copy of our

first report

changes, new in press; report on memory changes, also
in press; and a more elaborate summary, as submitted. The path
of current apparently influences the degree of EEG changes,
and the seizure also results in EEG changes (as after flurothyl)
and the separation of these effects interest us now.

on

2r

.
my

We are also interested in Inglis'suggestion of bifrontal
electrode placement yielding (in theory) less memory (and EEG?)
changes and have collected a few cases done this way.
—

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EEG

EEG

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Another important issue is the possibility of left temporal
accentuation after ECT with hitemporal electrode placement.
you confirm this observation?

.

My

Inn-y

best regards.

w

Sincerely yours,

01er

r,-.

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wwwmwkuarma

Fink, M.D.
Professor of Psychiatry

Max
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                    <text>r ww-wwwwra

Mar

wx—w—nwm

-.

.

April 5, 1971
Dr. G. Marjerrison

Associate Professor of Psychiatry
Univeratty Hospital

Saskatoon, Sask.

Canada

Dear Gordon,
Thank you for the notes about left temporal EEG accentuation
of slowing after seizures with bitemporal electrode placement.
Recently, J. Volavka repeated the measurements with our detailed
quantitative methods, and there is little question that the
difference is there. I don't know how we missed this in our
studies in the 1950’s, but we did miss it. We have no explanation.
We are
repeating the study, with spinal fluid chemistry
different electrode placements, and hopefully, monitoring themeasures,
seizures.
This last is a technical problem which is under study.
I hope to attend the last day of the 33? ~ (there is a pharmacology
meeting in Atlantic City on Friday~$eturday, and I am scheduled to
speak there).- and look forward to seeing you there. Many thanks for
the note.

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>July

Gordan

21 , 1965

M.D., Phd.D.Sc.
Mamm,
mspital

m
mama:
Nam Battlnford, Canada
Dear Dr.

143:3.sz
mmllaatim of a.

most pleasant naming in New York
by
and my «bay in answering is
stimhtcd your
occasioned not by disintmnt, hutby qmstims which am now
”me

was

lam,

in those Writes. Since
ﬁmim
mm,which
than
Marmara and pragmatic" charges
under

my

haw been

tbs mutation at my new appointmmta in 1966 difficult
the
at
present than. I very men magnet this situatim, and if
Iwindo
so. having that. in thc mammilc you may ham relocated elsewhere.

make

mfmtsmmdlfindlwakymtojoinm,

Mwaorymmintemtmdlhapethatwewﬂlhawm

opportmitytowrktogother.

Simmly

yours ,

ﬂax Fink, H.D.

Professor- of Paydaiatry

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“wwwwwwwmﬁm

7..wm-ﬁ.wmm—VWW—w—wrmuW...__._....

"—w—w.

Wem‘

_.__

Hey 17, 1971

Dr. Gordon Marjorrison
Department of Psychiatrv

University Hospital
Saskatoon, Canada

Dear Gordon,

I want to thank you for the pre~puhlication copy of your
study "Electrocnnvulsive lherapyt EEG and Clinical Effects."
I found it very interesting.

First, I am enclosing a copy of the proper citation for
the slow wave EEG differences, and suggest that both the text
and the reference list be corrected in galley. Bro. Volevka
and Veldetein have re~anelyzed this data quantitatively, and
the findings stand.
text, it is clear that the REC behavioral
reported were not replicated. But Table II vielde
another fact, that indeed depression scores increased with
increasing delta (9 &lt; .05, r - +.26 w +.29) i“§ﬁiié”§hx1ecv
and excitement decreased. In this correct?
In reading the

relations

we

I also find the correlations in Table IV confusion. The
negative correlations are consistent with our experience, but the
positive correlation of increased delta voltage and increased
scores in emotional withdrawal and conceptual disorganization
reflects some other process. Are these interpretations correct?

principal difference in our experience is in Table II.
a sun of the observations in schizOphrenic and
depressed patients combined, it may help understand the correlations.
Since the evquotions were done 1 week after a varied number of
trootnento, we voild expect the number of treatments to differ
for the two populations: and the impact on evmptome to differ.
Diagnosis did influence the delta scores on you note on page 5—6,
and perhaps this also influenced the behavioral correlations.
The

If this table is

�""W‘m‘

.m

-

Dr. Marjerrison

We

1..

—2-

are planning another

"rvuvt—v-Huwntmw —mm«qu-..v.—-—w--

May

17, 1971

study, to look into the delta

ECT

and its relation to behavior. In 1956 and 1961
I believed the slow waves after seizures were an outward index

lateralization

of the biochemical changes that underly improvement. Our recent
experiences, your report, and the studies by Small, suggest that
the EEG changes, like the memory changes, are non—specific indices
of brain perturbation, and only indirectly related to the behavioral
consequences. Something like the argument about the need for a
successful antipsychotic drug to induce parkinsonism a very
high correlation but surely not a causal or direct relationship.
—

The

studies should

go on.

Thanks

for the report.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>February 6, 1975

Gordon Merjerrison,

M.

D.

Department of Psychiatry
University of Sesketchevan
Saskatoon, Saskatchewan,
Canada SYN,

(1/

0WD

‘

Deer Gordon:
1.,

drug literature,
trying to catch up on the
an interested in some of your recent articles. In the study of diezepem
and trenxene (Stat. Pbychiat. Z; 31, 1973) your note (page 35): "...there
was e definite drug effect on the left-sided EEG amplitude measure for
each drug over time, the side which characteristically yields changes
in the signal measures which relate to psychoactive drug effects.
"Again (page 36) "...the coefficient of variation (left hemisphere

I

measurement)

and

EEG

am

increased..."

Can

I

assume

Including beta spindling?

the changes were not apparent

on

the right side?

Is there any other evidence_or the aide specificity for
Any other citations I can read?

drug effects?

another mattere I am interested in your EEG studies
with drugs: may I request reprints of your studies of pimozide
(canad. Psych. Ass. J. lg; h37. 1971), Chlorprothixene (Canad.Pbych.
Aae.J. 1g: 533. 1971) and whether that may be in press.
On

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

.'

,
A”,

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                    <text>Marah 2, 1964

J. ﬂirthsu, 3.3.

Kirk

Socrntntyurrcncurcr
Hontuftoru 89:91:51
Alana: Asuncineion
Gnu $111 Road

Huw

Yeti 67,

Run

turn

00¢: Dr. Markham:

I tum 1mm tam-cum in an Mm: “non-um of matte“,
my.dintanca
botvuau St. Lnuia and a.» task prucludcu any ancivo
ch.
patutatpation.

1 nu wt1ttna ca nuggunt that until sunk
may bu yuhliahgd. any 1: no: ha aqually

‘ tins

an chm Alumni Jaurnal

nuacaontul to distribute uh.
ﬂoatatiora Rauul¢tcnr ca an: alumni. as cut. otenu inaluaon snug:
ragurdtng tn: aettvlaisn a! tho prnlun: hospittl agar! a. wall as

th‘ ‘1“.ﬂ£b

I

am

planned to nanlo&amp;¢ u «#91 of

9!. straws.

my

currteulan vita;
Stuagtbly yautn.

ﬁnk.
m
Eiroauo:
”$138
ERG.

HOD!

an unquuitad by

�</text>
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                    <text>May

19. 1975

Richard Markin, Ph.D.

1102 N. Harlem Avenue

River Forest,

Illinois

60305

Dear Dr. Markin,
we have not used the
evoked
changes in the averaged
response as a cerebral index since
1966, and I lack the programs that you request. My work is focussed
changes
on the frequency analysis of the resting, alert EEG as

Thank you

for your inquiry.

it

under the influence of psychoactive substances.

principal laboratory working in the area you
seen interested is that of Dr. E. Roy John at the New York Medical
College and Dr. Sam Sutton at the New York State Psychiatric Institute.
These men are involved in studies of the AEP in cases of MED.
The

.._

.1r

You may silo be interested in following the work of
Charles Shagass of the Eastern Pennsylvania Psychiatric Institute. He
has been a pioneer in the IEP in psychiatric diagnosis and has many
computer programs for such measurnent.

4—

Pedersen on

vish to check the volume by Kellavay and
the computerized EEG analysis as applied to children.

right road.

Good

nu

..

.

‘
.
.'1'

"rm“?

.

«7..

r,"

You may

I trust these suggestions will get
luck.

you

started

down

Sincerely yours,

“an“...r.‘

Fink, M.D.
Professor of Psychiatry

Max

the

�</text>
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                    <text>19 March 1974

Houston,

E. A.

24.1).

Professor of “ontology
Sinai Hospital Bchool of Modicins

Mount

Fifth

How

Awooos and 98th

York,

How

Street

York 10029

Door Ed:

I

wont to thank you

Morris Sandor.

It

for inviting

no

to tho presentation for

in unfortunotc 3hct you second diusppoiutsd

1n the proscntation that Martin and I mode. You mcy toccll that
martin tscoivsd co invitation and I hsd not; and in response to
his toquost. I supported the ptoscntttion of tho 088 material.

I as taking the liberty of enclosing a draft copy of c pros~
notation I had undo two weak: one at c coating of the Amctican
Psychopathologicol Association. Encouraged by the subject of the
contoronos, "Evaluation of Psychothctoptos," I wanted to bring
to tho sttontion of this audience tho work which we had dons
sons goats outlier on tho relation of brain function and psychothcrspy. The theoretical model presented to a b1t.sttnincd,/but
I have no doubt that the continued oxplorntion of tho linguistic,
attitudinal, and pctccptusl changes with psychoactivc drugs pto~
video a spacial opportunity for undsrstaudtng tbs changes in the
dyadic tslctionship, oftcn ussd for thstopsntic purposoo.
My best regards.
Sincorcly yours,
Max

Fink,

M.D.

Ptofcssot of Psychiatry
MF/cto

Ecol.

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                    <text>[We

NWT—"y".—

(212) 369-7900 Ext. 245

April 25. 1969
Mr. Robert L. Marlin

Sandoz Pharmaceuticals
New Jersey 07936

Hanover,

Dear Mr. Merlin:
I have read the preliminary data on Sandoz 42-548
with
interest. It is possible that we can undertake an EEG profile.
but the earliest wouid be after the summer holidays.

I am enclosing

reprints describing our work as well as a
report of our observations in another anorexigenic.
fenfluramine.
preprint of

a

a

As an example of our approach
study of another compound.
As I

would you

I am

enclosing a protocol of

will be out of the country from May 2 to May 20,
my office and arrange to visit soon thereafter?

call

Thank you

for your interest.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>June 12, 1969
Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936

Dear Mr. Harlin:

Enclosed are two draft copies of our protocol for the
study of S 4-25h8, and a form FD 1572.

In the event this protocol

appreciate receiving 50,

2 mg

like
tablets are not available,

and a

is satisfactory, I

tablets (capsules) of

may

initial

S

-

"gr

Sincerely yours,

v'

.
—-l

-u'

.w

-;.V-.—

,r
v

_-

Pink, 11.1).
Professor of Psychiatry

Max

H.

1.2;“

,~
v.

,r
.-..

'

v

‘vxna...

'v-z'xaxxwwr

112m“

~15"-

wvw'."‘,"X7.nij'.:

MFtkp

4-2548

supply. If 2 mg
I request 100, 1 as active

number of placebo as an

and 100 placebo.

would

�</text>
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                    <text>August 12. 1969
Mr. Robert Mariin

Sandoz Pharmaceuticals

Hanover.

New

Jersay

Dear Bob,
we received the material shipped on July 28 on August 8.
Sines one bottle is sufficient. I am taking the iiberty of
returning the second set.

The

study wili begin within the next.week.
Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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.-~~.W ‘_—w:-vm-v~-.

,, w...—..m—m~——'-_—.»V.... ‘,)avw,——. -

m.

u m—r.ru

"va“.

January 19,
Mr. Robert

w_m_-»-- w._;_r~.WW. "tn“...

1970

Harlin

Sande: Pharmaceuticals
Hanover, New Jersey

Bear Bob,
Dr. Rothwell

DeceMber 22, 1969

called to discuss our interim report dated
of S~421548.

His criticism was well founded. I
of enclosing a revised page 8 and 9. I
you would remove page 8 from the report
to me or destroy it.

am

taking the liberty

would be grateful
and either return

Sinceraly yours,
Pink, %.D.
Professor of Psychiatry

Max

MF:kp

one.

if
it

7..

�</text>
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                    <text>February 6. 1970

,w

Mr. Robert Marlin

mwvrP-KI-"p—‘Il—IIWVF‘

Sande: Pharmaceuticals
Hanover, New Jersey

mm—m

..

Dear Mr. Marlin,

w-v.-u..y

&lt;

”-..—W)“-

"-

usu-wm-u

rmvl'"

,

7

Thank you for the information on thioridazine in
the treatment of anxiety in out-patients. The data is helpfui.
suggesting both a very broad range of dosages that may be
effective (30»300 mg/day) and a high degree of safety. There
is no satisfactory comparison against a standard antiﬁanxiety
agent, however, and I wonder why this has not been examined.
I checked my reference texts as well, and found some references for
a few of the antipsychotic agents. but none for Meiiarii.

.-u-

m

-qrv~

As I mentioned, we are inciined to undertake
of Meiioril in out~patient anxious neurotics.

The

a

study

study of 542.548 is progressing well.
Sincereiy yours,

-

7mm-

n.»

.....u—unyq-wwa-w

Fink. M.D.
Profossor of Psychiatry

Max
urn-w")

Jaw

A,»

.‘A‘v-W‘uy,“

,;,~w~g_

«m.

A

“’lwr'wa'yn’"!

wWVVm‘A't."

.
w

mf/

�</text>
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                    <text>\\

11‘

July 23,

1970

Mr. Robert Marlin

Sandor Pharmaceuticals
New Jersey 07936

Hanover,

Dear Bob,

Separately I am sending you a summary report and statistical
data of our two EEG studies of 8 42,548 in volunteers. In the
reported December 22, 1969, we defined a dose of
first study,
8
4.0 mg of 42,548 as adequate to alter the behavior of our
volunteer subjects.
'
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In the second study, reported here, we compared the EEG
profile of 8 42,548 to placebo. While many differences, particularly
in behavior and systolic blood pressure were observed, we were unable

to establish an EEG profile. As we discussed, the failure may relate
to the sample size or dose of 3 42,548 ~ or to the possibility that
its central effects are variable and unsystematic (at this dose).
There are two options that are of interest to us and meet
some of your needs. One is to extend this study by additional

subjects at 4.0 mg or by an additional 6»12 subjects at 6.0 mg,
in comparison to placebo, following this design. This will either
demarcate an EEG profile, or failing to do so, satisfy the
statisticians who may question our sample size.
The second

is to accept this data

and proceed with a

direct

comparison with dextroamphetamine in a larger sample. This compound
was the principal comparison in animal studies. If we define a
profile for dextroamphetamine and not for 8 42,548, we can be confident
that the CNS effects of 5 42,548 are less than amphetamine. Failure
to define a profile for dextroamphetamine will raise doubts as to
our technique.

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Hr. Robert Marlin

July 28,

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1970

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Before concluding the present study, however, you may wish to
arrange a review of our data with other investigators of 8 42,548,
both within and outside Sandoz Pharmaceuticals. I am leaving for
my holidays in August, and would be pleased to participate in such
a meeting in early September.

statisticians to
their analyses of the data, trusting that their results

I would also be pleased to meet with your

review

are similar (but hoping they find

more

than

we

did).

Incidentally, the study took much longer than I anticipated
Now
largely by our need to improve our statistics and programs. with
that these are fully operational, I am sure we can proceed
greater ease.
My thanks for your cooperation in this study - and my best
regards.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mszt

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September 28, 1970
rwwwmv“

Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936
Dear Bob,

I have read Loo Goldstoin’s report of his EEG analysis
of 42,548 with great intorost. The data is not inconsistent
with our own, and should therefore, be useful to you in your
3

,
r-

1",

decisions regarding this compound.

~—

vwn‘l

Thank you

for the opportunity to road this report.

w’i“|Wl-m-

‘

Sincerely yours,

Wam-m-w—u—wm

Fink, M.D.
Profossor of Psychiatry

Max
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October 20, 1970
Mr. Robert L. Marlin

Sande: Pharmaceuticals
Hanover, New Jersey 07936
Dear Bob,

In response to your
We

letter of

10/15/70:

Our experienced with S 42,548 are summarized in our report.
anticipate an Opportunity to review this study, particularly

sinco the study did not

elicit

a conventionally useful

The study was done in male adult
academic populations.

volunteers, derived

Sincerely yours,
Fink, M.D.
s
Profossor of Psychiatry

Max

MF:kt

profile.
from

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v-nrr-u'w

Wu‘.'wvv»‘ihw"i www- rtrru—a—v WI""W’~V‘

..

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,

To

WH’WI-v-m'

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October 31, 1968

- Who's Who
201 East Ohio

Marquis

Chicago,

Gentleman:

I leave just moeived the Tenth Edition of Who's Who in
Midwest. Effective July 1, I have relocated to New
and would be pleased to have the next entry included in the
volume marked "Who's Who in the East."

m

the

mum:

av,

.uwm

.4

u

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Professor of Psychiatry

Max

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Sincerely yours ,

(2'

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address for

39 Arleigh Road,
my ham
New
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�</text>
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                    <text>7

February 8, 1971
Mr. E. Marrese

Inmigration Specialist

New

State

York

Employment

Central Immigration Office

68~O9 198th

Corona,

New

Service

Street

York 11368

Dear Mr. Marreae:
Mr. Mark Komloai

will attach electrodes to scalp of subjects;

measure resistance: record brain waves: deliver electronic stimuli;
record responses. He will maintain equipment including, EEG, tape
recorder, oscilloscope and electronic stimuli generator. After each

experiment, he will analyze the data for final analysis.
The

”psychological tests" are electronic stimuli which require

judgements by the subject. The rate and strength of stimulation are
constantly monitored by the psychophysiology technician.

I have no copy of the advertisement in the ﬂow York Times.
appeared September 13, 1970 and was their copy No. 03197, Class 0049,
descriotion ~ Research.

It

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:kt

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                    <text>00W 22, 1963

.W,

M. 9.
Indus
Director md meeew
6
Widow of
Pittsbtm School of Medicine
mimity Whey
Voter“ Minimum
laboratories in Wychiatry
touch Farm Road

W

Pitta-arm 6, Permylvanie

he:

Dear madam

52112-1518

mattmkindmmtoMueseeywrlathI-ual
Ihopethetmit'sstimformtowdto
(Today
mamtmm,wwillhmmnemdmmoh.
ismﬁretamimaryofthsdedioaﬂmofﬂaisimtimmdu
IMWm,Itealmtheersae-dtohawsuwiwdﬂnvioiasi-

Report.

Wan!

Dr.

mammetimofmrmm).

{MmtlywituntoJomWnth
sstmwmdllodcfmaNtoeedngywinﬁmYmkinDemr
wmtnwthmdmagainuymdmmmw
smevdﬁdxywhmalreadyamieved
Sine-«1:1 yours,

m M. “a

Mar
Mauls
BC:

George A.

Ulett,

M.

D.

De

�</text>
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                    <text>Februery 28, 1966

Dr. Coeino Ajmone Moreen

EEG Journel
Notional Institutee of Health

The

KINDS ~ EEG

Bethesda 14, Herylend

Deer Dr. marten:

It is with greet pleasure that l encloee the corrected pege proofe
of the bibliography. We have made all the oortectiont recommended
by the editors. Following your euggeetion thet we review the refer»
encee in Dr. Breeier'e review, we beve recommended the addition of
nine citations. These ere each marked in the appropriate position
with the letter "a“. The requested changes have been made in the
author end subject indicee.
if listed ebetrect bee been reviewed end in the instances
which e complete article he: been published by these authors,
citation he: been ohenged to reflect the full erticle. In two in-

In eddition,

in

etencee the article wee elreedy lieted in the bibliography under
enother title, end tether then delete titles. we have had the phrase
"eeo

full article

ﬁ_“_?.

In working with the eubject index. my eeeooietee one I have found its
format too complex. The tee of two on deehee to repreeent the header
word in e column of subject references it quite eetietectory when e
single word it represented. When, however. two deebee. three deehee.
end on one occasion. four deehee ere need. end. these deehee flow
over onto the next column, the subject index become: completely ueeleee.
I would commend you tO'reeding Page 66 as an example.
consider modifying the subject index to limit the use of two
deehee
for single worde only? If this ie too expensive, would it
on
be poeeible for you to minimise the use of two dashes and exclude anyWould you

thing greater then that? One of the nejor use: for this bibliography
in the use of it: indicee end I believe we will be severely
crititireﬁ for the format of the eubject index.

must be

�Dr. Moreen
2—23—64

Page Two

were able to check each of your questions but one. I have been
unable to obtain a copy of Article 343 (More. 6. ottel., Ann. med.
psychol.. 1958, 116 (2): 202), to check the proper cpeliing of
B. Severgnini. You may recall that you reminded us that there in
e einilnr neon listed in Article 570. The Ipelling in this instance
is ”Severgini”, and this in the correct citation from the Riv. Neural.
I would be very grateful if your secretory could check with N.L.H. to
see if the nannies of 1958 are now back in the stocks. They were

We

absent

last

week.

Regarding the inquiry of our use of the Capitol World List of Scientific
Periodicals 1900-50, we have followed the recommendations of the
Journel. Vol. 14, p. 160. That one the official reference for the‘
Journal at the time the bibliogreohy wee tiret completed. We did diacoee this leot summer, and I believe that our citations are coneietent
with that. It would only be with e greet deel of effort that we could
modify our present citations to meet with the new specifications of the
Journal. I would request that you permit this one. no described in our

introduction.

Since undertaking this project. I have come to concur with yon: thought
that the only merit of each u bibliography is in it: meticulous accuracy.
For this reason, I would wish you to reqoec-t the editors to return

another net of galley proofs. While, in general. these proofs are very
good, we have found it neceesery to make correction: on every page. After
so much effort, it would be most helpful if we have another chance to make
the bibliography perfect.

Three week: ago I proniaed you a completed review article by this date.
and have been unable to ﬁolfill that promise. I on
I have been
continuing to work on thie. and hape that I can have it available two
weeks from today. If you find that this in an inordinate delay, I would

ill

recommend

that

Thank you

for all your helpful

you ccnylete the

publication of the bibliography

comments.

Sincerely yoore,
Hex

rink,

Director
MF/jb

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                    <text>«we

4“

WV

May

Ajm Marten,
N. LN. 13.3.
Casino

M.

21}

, 1963

D.

Netioml Imtitutes of Health
Bethesda 1'4, Maryland

DearDr. Harem:
and

’Ihmk you

lists.

for yam letter of

Regarding the points

are as follows:

May 20

and yam helpful suggestions

in yam letter, our present plans of procedme

1. Cmcsming point #1, all Journals will be abbreviated in
accordance with the World list. Should a Jozmal not be listed in

cfebbmvistionwillbeused. Ifthis
w ,thesamstyle
full title will be used and shall leave the
abbmvietim for you'- decision. latenwe
a list of
wele sendhaveyouphotocopied
such meels with the article mmber of m.
ywrWox-ld Listofablzuvistimssndammtumingittcyouwithﬁm

th'ismf

is

not possible, the

we

We

corrected World List (Third and last Edition) abbreviatims which we

shall use.
‘
«7»:

a
4-9-12th

~
&lt;

gmw

.x-

KHZ-WW”:

7‘

'

2. Regarding points #2 and #3,the ordering of erdcles will be
alphabetical and dumclogical as determined by the senior (or sole)
author. The enclosed List #2 illusu'ates the form: the sum
"W8" is listed after "Sam“ and all of the fonmnauthcr's publi~
cations em then listed dumologicslly, if he is senior author. This
is the system used throughout the bibliography.

missim of certain foreign-language
do this, and shall
explain in the introduction to which languages this applies. We shall
3.

titles

Item in regarding the

and bracketing the

do our best

tmnslstim--we will

in attemting “faithful" translations.

�b

i
i

2

'x

80311210

'N

Ajm Hanan, H.

D.

-2-

May

shall explain, in the intmduatim, item
inclusion of certain abstracts.
h.

We

#5

2“, 1963

meaning tin
.

5. As to point #6. we we mpting, a cut-off date of 1962. for
publications listad. Similarly. no article published prior to I951
will be listed. ’Ihua, 1951-4962 inclusive will be the range of dates

for listsd citations.

.

appreciate ymr offer of help and shall not hesitate to ask your
advice, shwldwebeemfrmtedwithanympmblemmgardingﬂzis
We

Again.

many

thanks for ycur interest and efforts in this project.
Sincerely yours ,
Max

Fink,

Dimctor

W352"

Emlosums:

List

#1

(yams); List

#2

(cum)

M.

D.

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                    <text>Hey 31, 1953

Dr. Cosimo
N.I.N.D.B.

Ajm Person

National Institutes of Health
Bethesda 1“, Maryland

Dearnr.

Mex-sen:

“mankyou

foryamlntterofﬂey28.regsrdingm

alptxabetioal-ohrmolomoel ordering of mfemnms.

but hope you will
sumt.
multhueindwzging‘memthodofmderingformsirdex. we
believe the bibliography will be met useful if the serial publicatim
Our
of the senior author
listed
we

mderstand the

method you

swictly accordingto cosmology.

are

is that the continuation of an eumor's studies in a particular
area is heat followed if his publication are listed strictly dimologically. If, hmever, priority is given to the alphabetical order
of his coworkers. the progressive nature of big' work is not readily
meson

apparent.

is

illustrated by the author ”Singers",
listedmtheemlepegemoentymendmretmingwidmthis letter.
The progress in his development of e sedation and e sleep threshold is
easily followed in our enmeshed ordering. Giving priority to m almabetioal listing does not appear to us to serve «m useful a propose to
we

think this point

well

readers
he

Ofooume.vmenoneofmeoo-aumombeoanesaseniorouﬂwr.

is listed in his proper place in the alpmbetiosl ordering. In the

"W

woof
ecu-workers

,mdnebovewmentimdeemplepage. notomofhis

has published indepemently within the am of study oovered
by this bibliomphy. This serves to support our thesis ﬁrst priority
should be given to ohrmologiosl order of senior outlaw. radar dun
elptubetioel—olmloﬁoel order inclusive of oo-eumors . as you suggested.

Wesmnmitywrdecisimon
minnow. beforewemahgeme
we have followed.

medzod of ordering

'mank you

for your patience.
‘

Mfzjr

.

.

e“ 5f;

3
.

r,

V

,.;,1

4%

5%";

‘7"

1.3L

Sincerely
Max

Pink,

Director

your.
H. D.

�</text>
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                    <text>Jm 10, 1963
Dr. Mary Goldenhorg
Daparumnt of Biodmiotry

Hillside tbspital

P. 0. Box 38
Glen Oaks, New York

Wth

Dear Harry:

founontlmlhavobaanpmocoupiedbyall

tincrgminatiaulmblmatamwlabommxy. Ihavahon
fortmtaintmviramgoodaciontiats joinmoanditiowith

nanotomofthaoathatlamwritingthia Mo.
Dr.

SamGarﬂm,apMmaaologiatand paydxiatrist,haobeon

studying for a umber of yaars the effacts of anticholimrgio
omnpmmda and their hlookhg agents on behavior. Specifically ,
he has boon interested in
and the blocking agent

mm

mtmhyminacrin Tboontimomaoastudioa,woammakmg

available fmmormclinicalmit. mdamnowin
mpatimts
of establishing our animal laboratories. Thom will
the
process

also contain facilitiaa for dogs and will permit animal seasoning
of a wide variety of antioholitm'gic and blockim agents. Hmvar,

bothheandlmintmtodmominthcstmiasofcmlimrgic

mohanim of the nervous ayatm than in doswibim the affects
ofcompomds. Ywmaymoallmyahortivaattewtmymago
to study tho acetylcholim levels in spinal fluid and new no. Gamma

aMIwiahoommmthoacotudiesagain.
lboarrywtﬂmsastmics,uaamlookingforanaoaooiatein
biochemistry with specific intomst in acetyldwlim, oinlinorgic
moiwﬁm, andmmohmm.1mwritingooaokmﬂuryouom
Woofyourmiatymmightboinmmmdina
first rate msaamh opportunity at this mam owner.
I would be most grateful for your mmndations. My best

Wow

”5.8m to

ViVimo

Simmly yours,

ﬁrm;
4

Fiﬁ, "a
m
Dimctor

Do
~

�</text>
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                    <text>June 28, 1963

Cosmo

Aim Mman. M.

I).

National Inatitutes of Health

NINDB

«-

EEG

Bethesda 1n, Marylmxd

Barnum-sen:
First, letme thankymforyowwopemtimandmmny

kindneeees during hrs. Bmm's visit. Again, we have made sum
decisions following mm meomendatims and I will send you a
ample “introduction" within the next ten days.

m

IBM cards and e printmt.
Meanwhile, I am enclosing
Rather than have the secretaries type the many pages of the
references, it will be easier to have these pmemd on IBM came.
Once pmched, they are easily verified and corrected. Listings
am readily made. When the bibliography appears, we can mks
the cards We tape) available to those madam wm have IBM
equipmnt and ear: pay the cost of reproduction.
,

Maven, the references going to the printer will have to be

inthe'attaahedtype farmat. Thereieonlyone case. Thereie
no underlining possible. (We can do this by hand for the printer.)
We can. also, either use a (-i) to indicate words
wapleted in
the next line; or have no incomplete words; or omit the (-) sign
at the and of the line. Some characters are absent, i.e, qmtation
mks, colm,,eemioolon, mam-xi.
i

\

�Cosimo Ajmme Mar-31m,

M.

D.

~2~

June 28, 1963

madmylluveyourmncmnce
lemmmattacmd,
to send
the manuscript using this type.
(1) Single. double, or triple spaced?
(2)
titles, citation on

mm.

same

author/title/ciggtion

(3)

May we

for

substitute:
:

for g
for and
for quotation

lines;

?

,

2

4,
+

**

W
*

and 'f

The identification and cam timbers will
appear in the
final print out. If the publialnr will awe,not
the mole operation
is greatly facilitated.
Many

thanks.
Sinmnely yam-a,
Max

Fink,

Director
Mfajr
Enclosures

M.

D.

�</text>
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                    <text>July so,

Cosimo Ajmom Human,
The EEG Joumal

M.

National Institutes of
-EEG
Bethesda 11:, Maryland

NINDB

1953

D.

With

Dear Dr. Karen:

penultimate listing of the Italian citation-is for the
These
lave been ohsdcsd repeatedly, and remaining
EEGbibliogrephy.
from
our look of sophistioatim with Italian. Would
errors may result
Enclosed

is a

,

ywbesokimiastoohodcmse fortrmlatimaommoyaswellas
the correctness of style? If this is satisfactory the whole list will
be completed by mid-anst.
Regarding your letter of July 15, we have trade the following
adjustmnts.

(Item 1) The foreigi omjmotim between name of More has
been used. except
(Item 2) for those foreign language articles whim have translated
titles only. in which case "and" is the omjunction med.
This applies to citations in: mission. Polish, Czech,
Hungrian, Japanese, mime, Web, Yugoslavian.
Bulgarian. Soandanavian and one Portume.
3)
In the foreigi language oitstims listed show ( in
(Item
Item 2). the original Imgmga of the oitstim is indicated
in parentheses at the end of the citatim, following the
i

(Item

H)

page rumors.

axiom mshall
-

strange

the

*
e

pres
‘ J“.Hﬂﬁsieﬂmpublism's
would prefer not to make any omen

abbreviation

-

whim differ from the World List,
amigos
alloudngtmpub shertonshe such special cases as the
Journal may require.

�'-2'~

Casino Ajmma Human. um.

July so.

1963

a. Will not Mrﬁm.
wwwmwplmmtodwmatendoflim
(althmm. in the can: of forming. it is misma-

b.

allynooessaxy). mandamus,
of than chemical
a. Triple spacing will be mad.

d.

a.

We

have

rm.

milled with

instuctims. In order

the

we have. had

to

lhemeof+mmemrmdhasnotbmnmdin

place of ”and” in joining

a. Eh.

j.

7

to avoid hyphenated words, hmvar.
have portions of was unwed.

ms
f. WeMWmd=inplamof=

1.

mehypmnispm

*

,

hmd.
A

of armors.

Seni-colbnandquotaﬁmmmminby

single wmriak has been usad for square buckets.
letter Ohm bean med fwall mm in the

The

citatims.

,

.
4

is a list of journal titles in abbreviated fem for
not in the third aditim of the World List. These abbmviatim
fella»: the "style" of the World List but‘we rave nc' ”official" basis for
these. Please check each one and approva or Mifyaccording to the
Journal style.
Also enclosed

jams

-

mmis available. We also removed references mlatad to
full paper
tha use of draw for epilepsy activatim, including mtmzol, PR 1090 ,
We

which a

have

mgemida, except

m reference for abstracts, and deleted those fer

Wham

the use

was,

clearly cm of psychiatric therapy.

L

\.
E

thmks for your help
pat few weeks.
final 009135 of the mfe‘mnm
not agpear in the final draft.
Many

program those
00m.

and amnts. I am quite pleased with'tho
and should be able to produce "elem“

with ease. (The identifying numbers will
being mplaeed by a sequential numrioal

‘

,

Simly yours ,

m Fink,

szr
mellow

M.

D.

I

�</text>
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                    <text>October 15 . 1963

Aim Hanan, M.

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two copies

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Sineeruly yams.
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                    <text>March 15, 195a

Aim Momma

Dr. Cosmo
Tm EEG Journal

National Institutos of health
NINDB

w

&lt;1:

-

~p‘WW-4

~

Bethesda 1n, Maryland

mm. Man:

I mmt thatlamumbla to doliverthe dammit tobeadded
to the Bibliomohy, as stated in our earlier oomersatims.
The failure to accomplish this mission is we. in part, to a
severe illness" these many weeks; but also to m awareness that
the overview I um promoting would be insufficient unless it
was more fully documented than originally planned.
had available an ovozviw which was similar to Dr. Brazier's
articls, but with the appeamnoo of her report .3I became
My concern is related to the foot ﬂat
single
our madmions
statemnt would no longar suffice aims,
differed, I would have to moment the diffmnoes very fully
to be credible. To do so has required a detailed review of the
literature, and this is now in progress, md will not be

I

196%

ammo.
for a

few

if

mien

mom.

wwld Rosamond that the Bibliography be published as originally
plmd. Tm new dommsnt will be submitted

I

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accept

proofs book

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in not

11y

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tul for your Mlp

and

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difficulties I haw cameo you.
the mission. I on wet emce-

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of receipt.
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Sinmmly yours ,
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get tho

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                    <text>June 3, 1969
137'.

Cosmo

Ajm Mar-am

Natimal Ins'tituteﬁ of Health
Bethesda, Maryland

Dear W.

20011}

W:

Imﬂymmmdesimtommtotkmmmsof

the Cawsmdamplemitoabidebymemles, trusting
ﬁxatﬁxecmzait‘tw willbeequally judiciom forallnwbem.
The mgm "2338 Changes of the Narcotics Heroin ma
,
He'dmdone" shmld be listed with the
PM). ,
J.
Mimic,
J. Volavka, PM)” A. Zeal-cs, HA). and A. H. Freeman,
Hub.

mm

The

report “Lib

Mas of Opiate imtagmists” is wiﬂximm.

Mummmysioalﬁodeloftmmkowmseto
Mum
is witrmn.
WW
Pentattml”

I mule: like to subatimte the 611610866 abstract ”EEG
Patterns as an Index of clinical Activity of Psychoaetivn Lungs"
by ﬂax Fink, PM}. md Daniel 1%. gimpim, D.Sc. imtaad of the
report "Mtitative 2136 Analysis of mug-Induced
in

mammas in Mm" by Pink,

ﬁaﬂcyoufmyourooopamﬁm.

“inﬂating WW8.

A1th

mu: Emapim.

11:11

Wheatwishesfwa

Sincerely yams,

rm Pink,

1M).

Professor of Psychiatry

�</text>
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                    <text>'V'

“W'N‘Jmiwmmﬁnm-wurawn-r-

.mw-

\ ,.

- ”r."

w,”

v.04...“

.—

-nm‘;m&lt;mm—..

A

December 28, l967
Dr. Charles E. Marshall

Associate Director of

Clinical Research

ninthrop Laboratories

90 Park Avenue
New York, New York l00l6
Dear Dr. Marshall:

Enclosed is a draft copy of a proposed study of oxypertine.
\After reviewing the available literature and discussing the
clinical data with Dr. Hollister, my associates and I would
like to recommend an EEG study. It is our belief, that such
a study will provide data not otherwise available, which may
be most useful in identifying the target populations for this
psychoactive compound.
The

new York Medical Colleoe will be
lose. I
undertake such a study about harch

facilities at the

l,
available to
of
the
University
associates
at
of
my
have
the
assurance
also
when
Missouri who are willing to carry out parallel studies,
they are necessary.

In addition, we would like to consider a clinical study
the
in
population of the Mental Health Clinic, as soon as we
have detennined the EEG profile and made some recommendations
based upon that experience. In that study, we would like to
carry out a procedure similar to that followed in the clinical
evaluation of cyclazocine as an antidepressant.
I would be grateful for your comments. In the interim,
please accept my best wishes for a Prosperous and Happy hen
Year.

Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>August 1, 1968
Dr. Charles E. Marshall

Associate Director of

Clinical Research
Winthrop Laboratories
90 Park Avenue
New

York, New York 10016

Dear Dr. Marshall:
Some months ago we discussed a study of parenteral
oxypertine in volunteers. I have recently begun such a
study with one unknown compound and it would be convenient
at this time to introduce OXypertine as one of the
experimental drugs.

it

If such
with you.

is possible,

My

I

would be pleased to discuss

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

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                    <text>PP;
“5’2“.“

“1??”

M;VHW:W

December 3, 1963

AIR MAIL

Hamler

Hr. Marc P.

Division of Ommmicable Diseases

Wowld

Hum Omanimﬁm
'Switmlm

Geneva.

Dear Mr.

of

War:

In discussing cm-

York. he indicated

ocmmn

intemts

with Dr. Joseph Jaffe

that you were experienced in varicus
automatic
of
I m writing, first to
domntatim.
matures
obtain copies of you? meant Wales. especially mouse prepared
for the ”mom Swim of NW», 1963.
New

mam

imtitutim is a raw
facility, affiliated
of its endeavm with Wmhington adversity. My am
intemts are similar to
of Dr. Jaffe in pm. In additian, we are maxim to provide faeilities for psychiatric research. Central to these will be a Wntation cutter. It
was for this mason, in part. that we boom imdiately affiliatad with the mumr
of Washington Univamity. That
center has an IBM 7072 facility. This imtitutim has been
equipmd with an IBM 1710-1620 unit, largely became we have
in malog-to-digital mansion. Our
special
via: the thivamity provides for the: mtual madammugsof
ﬁrm.
in

This

many

m

mm

mt 1:3th
amt”
up.

Jaffe intimated that you may be intemstad in

coming

to the United States. In the event that that interest 31:11.1
exists, I should be pleased to diacma such an appoinmnt with
the staff at the Mmity. It may be possible that your expeniance would

fit in very well with

cum

mtual needs.

y

�1963
3, War
Dem
Page
m». Mam P.
Two

Dr. Jaffe extends his best regards.

Sincerely youm,
Max

Fink.

Diameter

Mfzmlg

M.

D.

�</text>
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                    <text>December, 19, 1963

Marmaler
12, me de la Dole
Geneva, Switzerlmd

Mr. Mam P.

M

Mr.

Winn

for your letter and for the articles.
For a umber of yum , I have been interested in developing
an informatics: retrieval oystem for references in psydwphlmacolow,
in
psychiatry, and psyomlow. This Imtitute, wlﬁoh was
of 1962. hm a 5,000 volume library as its initial collecthe
tion, and has an aooessim rate of 1,500 volume per year. An additional descriptim of the Institute is enclosed.
Thank you very much

am

,

The needs of the system include the
as they appear in a wide range of jmmels;

identificatim of articles
notificatim of scientists

that articles that may be of interest 1:01:er have appoamd; a coding
system for titles, abstracts, and mprinm which would permit us to
make
for minke of interest both within cur- own collection
Ideally, the retrieval system
and, if possible, from other
otmuld be established to clmoify articles as they appear and then, depending on the availability of funds, go back for as many years as may

W

1

we.

be reasonable.

In past years, I dewlopod a mitem system for our library,
but fomd this too Wroclaw. It depended menstruating by the professional scientists of the laboratory and these men were never con~
cistern: in their ways of classifying articles. In the past few years ,
the availability of amputer equipment has otinulated our interest to
develop a. commuter based information processing system.
The

Institute 1m available its

WK memory and random

ate access for up to

own IBM 1710-1520

access disk accessories. The

two

Wrap with
immedi-

latter permits

million ohamotm for each disk and provides

m1

�Mr. Ham P.

W

December 19, 1963
Page Two

icbal way of maintaining the water citation files. This facility is
IBM 7072 at the university and thmgh our disks, one am
$19 to use their facility very easily.
At the present tin. the Institute has two nodical librarians
and an abotmctor. I would like to consider the appointmnt of somebody
like yourself to develop an Womanim processing system for the hybrid
field of psychophmoolow.

backed by the

Mamitudeofthepmblemcanbestbeseonbymforringto
Abstracts, a plblioatim for 1961 and 1962. Articles
included in these abstracts form the halo of the interest of the In-

Psydmoykmxmcolow

stitute. Hoover, there are scientists
are

represented by

these abstracts.

whose

interests are broader than

I balieve we would be interested in ramming more of your experianon in devoloping such system. It is apparent frm your mfemnoos that
is not clear as to the present
you have prepared a project proposal, but
would
be pleased to know more
My
and
associates
I
of
that project.
status
abcut that promo. as well as any suggestions you my how for developing such a program here. I have taken the liberty of discussing your
miwlum vita with the director of the computer oenter and the assistant
provost at Washington University and any mommndations for appointmnt
would be made in cmjmctim with the Univemity.

it

Sincerely yours,
Max

Fink,

Director

Mrzmlg

ﬁne. 1

M.

D.

�</text>
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            <elementTextContainer>
              <elementText elementTextId="7412">
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          <element elementId="48">
            <name>Source</name>
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              <elementText elementTextId="7413">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="101540">
                    <text>Jana 10, 196‘
.&lt;&lt;

~—-&lt;

,

-

Dr. H32: 2. Marthnler
12, rue dz 1: Bola
Geneva. Switzerland

&lt;

A-‘r‘r‘m

‘

.wW

Dear Dr. Mgwthaicr:

Ju'lmnv:

:Mnx

I hava again explored tha possibility of yaur appointmcnt within
the computcr.canter programs at both this institute and that of
Unnhington University. I regret that we are unable to offer you
an appointmcnt at this time and hops that you can find the opportunity

It is

you wish

at the International

Labour

Office.

expectation that I will be in Geneva during the third
my macntion.'an&amp; I would like to take the
opportunity to call on you at that time, in the hape that you
will be available and that I may discuss with you your program:
and our problems.
my

wuak

in

Good

luck.

August during

Mr

“

'

Sincerely yours,

mwvrrumwa

Max

Fink,

Director

m/Jh

”J
,3”!
«

'3‘
W.

‘73;

‘
‘

I5"?

~.

-

1"“:

«Ayn:

w-vn

‘1‘!-.'

A

.3,

11“”?

?j.

u
.

A,"

I

,

M. D.

�</text>
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              <elementText elementTextId="11272">
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Format</name>
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            <elementTextContainer>
              <elementText elementTextId="81890">
                <text>application/pdf</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="88451">
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          </element>
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            <elementTextContainer>
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  </item>
  <item itemId="1205" public="1" featured="0">
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                  <elementText elementTextId="101618">
                    <text>July 1?. 1964

Dr. Marc P. Marthaler
12. rue do 1: D310.

Geneva, Switzerlnnd

Dear Dr. Marthaler:

plans are to be in Geneva from Rodnesday, August 19,
to Saturday. August 22. I plan to be staying at the
Hotel Pulse. 1n Montroux.

My

'

I will call your office wodnosday‘aftornoon

and

Lf'it

1: possible, I would like to spend some time with you
on Thursdny or Friday. August 20 or 21.
Sincerely yours.
Fink,
Director

Max

Mm»
.1;

,l

mum-”nww.

mawmume

M. 1).

�</text>
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              <elementText elementTextId="12051">
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            <elementTextContainer>
              <elementText elementTextId="12052">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
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          </element>
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              <elementText elementTextId="81968">
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
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            <elementTextContainer>
              <elementText elementTextId="88529">
                <text/>
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    <fileContainer>
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                  <elementText elementTextId="101797">
                    <text>Decelnber 28, 1961;

Dr.‘Marc. P. Marthaler
.12, me de la Dole
Geneva, Switzerland
Dear Mr.

Wen

'

Since my visit to Geneva, the growth of our Docunentatim
Center has been rapid. Despite the fact that we are a small research
unit, the Institute has recently beams an integral part of the
University of Missouri. The Assistant Dean of the Medical School and
the chief librarian have encouraged us to continue in the establish—
nent of a mjor Doctmentatim Center for psychiatric literature.
During the past few months, the Muter Center at the Institute has
provided us with the basic cwputer program for the retrieval of
citatims using the principles of coordinate indeidng. We have recently
denmstmted the system, using slightly less than 1, 000 citations,
to the staff and their respmse has been encouraging.

It is our intention to continue to support the grmth of
this center using the available funds of the Institute during the
next year. During this period we will explore the possibilities of
support from the Federal Govermxent to our Center or to a. larger unit
to be established at the University of Missouri.
Recogmizing your

interest,

and

recalling my visit, I have
Insofar
to ask

recommended your appointment as a consultant to this project.
.as we lack the proficiencies of a doczmentalist, we would like
you to provide technical help in establishing this center. In
that full scale support becomes available,
is our intention
commend

Dommentatim Center, and

I

would

the event

to relook forward to your interest in

the establishment of the position

such a position.

it
of

a director for the

�~2-

December 28, 196“

.

I

Dr. Mam.

P.,Marthaler

For these mama, and heme
this center as rapidly as possible, the

_

are amdous to establish
of the Departmnt
would like to request the Psychiatric Resoanoh Foundation of Missouri
to make available such ftmds as may be necessary for your participation

mm

we

in this plaming stage. If this project is of interest to you, would
youbeable tocanetoSt. MSWgthenexthoeweeks fora
2 week period? We would be prepared to defray your transportation
1
expenses, a masmable living allowance in St. Louis, and an honorarium
-—

Wewouldlﬂwyoutopartici teintheplemningofa
water for psychiatric onnation, and to indicate your
participation in this center onoo it is properly ﬁmded. If this
oppormmity interests you, I should be pleased to try to mange the
documentation

necessary ﬁocments for your

visit.

My best regards
My best wishes for a stimulating New Year.
to your wife, whose-hospitality is remmbemd with pleaswe.

Sinoemly yours,
Max

Fink,

M.D.

Exec. Director

�</text>
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                    <text>Mar¢h 30. 1965

Harchalar
Information Scientist
12, run an In Dole

Mr. Hare P.

Gonnva,

Suitscrland

Ens: Enrc:
A: I vrcea to you enriier. theta have baa“ many ahangos
in this Depart-ant in the 1:3: for nonthl. and tho nocnnnncaclan Canter trogrln 1: I temporary casualty. Whilc two of the
inst-etgntorn arc spin; dhaad in planning the progran. tho
annrtnnn: Chairman is unable to bring hinlolf to a decision

:nsnrdtng ouztida :onaulnnnto an ab. pznacnt

till.

'I would suggoaa, chtrctorc. that you nah: vhatnvnr
you can to «antinuo yuur ptecont progran. In the avnnt

an at: ail: to «stand our invitation again.
Dopartuun: Chairman to do so.

plan:
that

I will ask the

Stncntuly yours.
w“.“l—_‘

“It nah.

'I‘wv:

H. D.

Profasnor of Psychiatry

wrn-r

litkp

.

�</text>
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                    <text>July 30,

Mr. Wm: P.

1965

Muller

Information Scientist
12, run do la Dole

Gama, Witurland
Bur Harm

Ihava madymr'pmgmso mport with ISIS aswallas the
of
list swat-d topics for futon martin. My associates and
I or: vary and: impmood with this mport and believe that you

Manolo job.
ham has taken a paydmologioal twist and and:
prom
plaond on the
is

am doing a
mo

mmum

Mia
maria:

primrily psymlogioal,
of abotmotors. '33 original intontim of gutting up a. ragimal
cantor hm Man disbandod mo in its stead, is a
project to more the ability of different classes of individuals
to abstract scientific doommnts in the specialized field of

P9?

‘6

Madcoisimhavabompainfultomforlbeliaveﬂmt

a documentation: cantor using the best traimd doomtalioto would
be an asset to our commity. Only after we have had axtensive
oxperienoe with a variety of abstraotom would I be than interested
in testing, periupa, the psychological
of those
that do the best job. However, tho Division Diraotor has
mfemd the responsibilities for this program to a clinical

Wadstios

that is that.
Pertmpo I will be in Switurlmd this fall, and if so, I would
hope that I could call you and perhaps mtum your kindness last
year and your patient: (hiring this carcinoma of letters.
psychologist,

mad

‘

‘

Koap up

the very find work.

My

best regards.

Simmly

youm ,

Fink, 11.1).
Professor of Psychiatry

Max
MFﬂcp

�</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="18817">
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              <elementText elementTextId="18818">
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            <elementTextContainer>
              <elementText elementTextId="18821">
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            <elementTextContainer>
              <elementText elementTextId="18822">
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                  <elementText elementTextId="101986">
                    <text>Number
Mr. Marc P.

29 , 1965

Harthaler

12, mo do In Dole
Geneva, Switzerlmd

WW:
I

Via-half

would be pleasod to sand a letter of reference m yam
to me U. S. Gwammnt. They are ludcy to get you and

I hope that your Wig to this comtry will make it possible
for m to get together one: again to discuss our interests.

me program here has not received the swport whim it
In part, I believe this manned from our failm
minted.
to obtain the judgement and ammo of workers in the field like

molt.
Idonothmmtﬁmmhmofmmmt
will
do, and
so am very delighted to know that you have another
way of owing to this why.
I

write a

look forward

letter on

to seeing

your behalf.

you soon and

will be pleased to

Shoemly yours ,
Max

Fink,

24.1”).

Professor of Psymiatr-y

"Fug:

�</text>
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                    <text>,

w“

‘

V.

,» -.~vr :‘mv.v‘-'WF.~',

w—w—

, .,

mm

,1

,

-. v

\"u 3-

““7

u‘

any. «n—

NV-r-v.‘

.~

uw—v wan—r ww-r—r‘wrwxmw

‘v‘rww—V

“iv—T.

7..

n. kuqu. -vm~“-n

mrmmwuww 5—».qu

"V'rwvruurt-E

MM

December 11. 1975

Dr. Boston Martin

Chief, Spinal Cord Injury Service
East Orange V. A. Hospital
East Orange, N. J. 07019

martin,

Dear Dr.

The work

with

ACTH

h~10

htl

been aeueribed in exccllent
318%, 1975 by Jtan

detail in "scieneo," August 23th and August
I

Mnrx.

in

man.

eonmend

to

these artialca to you.

David da Wied but not publinhed any work on Vasopreasen
my knovladge.
I do not have a file on his animal studies.

feel thn$ there 1: an applicntion for
at the V. A.. it may be useful for you to
know thax I hold the IND for human studies and would be glad to discuss tha project with you.

ACQB

h~10

Should you

in your

work

Sincerely yourn,

Mb:

Fink,

M.D.

Protester of Psyuhistry

MF/nr

�</text>
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                    <text>Novanber' 1'4, 1966

4'

"rm”.wvw-IMV‘W‘

»

Dr. Eric Martin, Chairman
Membership Cmmittee

Drug Information Association
12 Bonnybrook Road

Montvale,

New

Jersey

076145

Dear Dr. Martin:
My

w

a

"'.u'uv'|v—

eme'r

hr"

associate,

Dr. Turan

Itil

of St. Louis ,, suggested

that I write directly to you for information regarding the
programs and membership in the drug information association.
I would be grateful for any information regarding the
association that you may make available.

4

Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max

mfkp
9:-

71"?)

m

1".‘l'mr‘rw

'&lt;-‘

"
1

--:vm&lt;'“m

,

�</text>
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                    <text>June 18, 1964

.

Dr. Gerhard E. Martin
1812 East 15th Terrace
Kansas City 27, Missouri
Daar Dr. Martin:

for your letter of June 15. You suggested coming to
on Monday. July 13. and this date is satisfactory with
both Dr. Ulett and myself. We shall be looking forward to seeing
you at about 3 o'clock in the afternoon.
Thank you

St. Louis

Sincerely yours,
Fink,
Director

Max

Mrljb

M.

D.

�</text>
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                    <text>November 20, 1967

William Martin
NIMh Narcctics Research

Lexington Kentucky
'

'

Facility

Dear Si11,
ﬁe would

like to undertake some studies with tetrahydro»

have been toId that we wii] have to file our
At 9?. Levine’s suggestion. I am writing to request
your permission to refer to the pharmacaIQQic data in'your
1&amp;3 when we file our own.r May we do so?

cannabinol.

own

Ifkﬁ

we

.

Taank you

for yaur ccaperatian.
Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max
HF : kt:

�</text>
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                    <text>«w

w

«yr-u

MA

yup

”ram—i

«nan.

z:

DWI-7

vn-

«are

”5.2-:

October 5th, 1972
Dr. William Martin,

N,I.M.H.,
narcotic Addiction Research Center,
Lexington, Kentucky.
.

Deer

Bill;
yDick.Reenich has recently extended the dose of

cycleeccine for a group of patients at MetrOpcliten
_

Hospital,

and hes

epperently,elicited tolerance to the

unpleasant effects of cyclﬁnocine. With heroin challenges,
he has observed en extension of effective antagonism
to 25 mg. heroin for more than R8 hours, suggesting that
a trial of cyclezocine en-e three times a week schedule

might be

we

._

‘21:;
,
.

"r
'm

‘-‘1m‘5&lt;"};é

feasible.

Whoderd

of

are editing for results of the studies by
M5050; and the supplies of EN-l639A from

ENDO.

Harold Blunberg told me of a meeting on the
categoniete, promoted by the National Institute of Mental
Health, and labelled the first such conference. I regret
that our laboratory has not been invited to participate;
and also regret that the history of the work in this field,
which is of such short duration, is already so rapidly
forgotten by officieldom, In addition to Resnick'e report,
which he has submitted to the American Psychiatric Association
for their May meeting, I am pleased to enclose a copy of
e summery of work on the Narcotic Antagonists, which I
recently completed. In addition to the compounds listed.
I am aware of two additional entegoniete under study in Europe
one by Jenesen end one by Orgenon « but I did not obtain the
structural formulae in time to include them in this summary.
I am very greteful to you, particularly for your 1967 review,
to which I referrdd moat extensively.
_

my

best regards,
Sincerely yours,

MF/id
Enos,

Mex

Fink,

M.D.

~

�</text>
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                    <text>December 19th. 19??

Dr. William Martin,

Director, ﬁational Institute for

Mbntal

Health Aadiction Research Center,
aexington, Kentucky.
Dear
mm;

mm“

v
"n“

'«w-ﬁmu

re
.«1‘:

9w-

m-wm‘nm“

mpavaah'mrwmzwz:

1-,“:

oﬁn’;

Bill,

'Last year I was invitad £0 lectura in Europe on
aur experiencea with the narcotic antagonists. After
I had indicated the need far longer lasting ana pure
narcotic antagonists, the vicenprasiﬁent 0t M.V. Organon
sent ma the analoseﬁ memorandum on a compound

n—cyclepropylmethylnoroxycoﬁone hydrdbromide (0130).
After raading thia documant I was imyresaed that the
compound

warranted further atuay. In seeking the

as

(3138050) and was presented

aubmissiona
UMkT3

The

the

I

found

presentation
compound

I

is

13

that this

campound had been

in the

HBO

tented

196k meeting.

ﬁnadequate, but the data suggests

long noting and an antagonist.

to advisa them
along the proper steps to ba takan to furthar develop

this

havn bean asked by H.V. Organon

compound.

gm,

w

,‘II'I'I-t‘

"m:

:-.-g=,-,-s-gpvw:qnmw

1»),-

Wm?

Ordinarily. I would havu hesitated procaeding further,
but 1n‘raading your report on naitrexone I have become

that this aanpound may alsa exhibit some of the
nannistia features which hays tended ta discredit

anxious

cycluaoeine.

I vauld appreeiaze

your sdvica as ta whether 0130
warrant: turthar investigntion. All the awaildblc data
is in the enclosed manorandum. Further study would
raquire animal toxicology similar to thong undertaken for
diprcnorphine and it ”clean" furtbgr human touting.
unfbrtunately H.V. Organon does not hold the patent for this
formulation gnd tharefbre, their principal interest is in
contributing to our information. I believu they vauld
make the cumpound awnilable and vould cooperate to the
artent practicable should.vn encourage it.

�Dr. William martin

I

~2—

December 19kt. 1972

would ask that you keep the information confidential
until I have had an opportunity to discuss
with you.
I would bo grateful if you would take the time to advise
us. for I know of no—one else whose View of the narcotic

it

antagonists in so clear.

year.

my

very best wishes for a auocosnful and happy
Sincerely yours,

Mo: Fink, M.D.
Professor of Psychiatry

MF/ 1;;

new

�</text>
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January 21, 1973
William R. Martin, M.D.
Chief, NINE Addiction Research Center

P.0.

Box 2000

Dear

Bill,

Lexington, Kentucky

It

was

hOSOT

kind of you to express an interest in

01—30.

(n-cyclopropylmethylnoroxycodone). I have Just returned from
London enﬂ under seperete cover, am sending you 1.9 grant, for
your evaluations.

Should the compouna exhibit characteristics that
would stimulate our interest in clinical trials, I have been
ensured by the research stuff at Orgenon that they would be prepared

to engage in additional studies and production.

I
,.

hope something comes of

Many

thanks for your

this.

interest.

‘
V

_

...&lt;,

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Sincerely yours,

,.,,

t

wmwrrtxwwrvwghyw

«w

WWW",

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Fink, M.D.
Professor of Psychiatry

Mex

V

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                    <text>October 25. 197k
John Stern, Ph.d.
Department of Psychology
Washington University

St. Louis.

Mo.

3w-

Dear John:

for lunch. On Thursday I was able to
visit
Ierjenorry to see how quiet and how
empty the laboratories were. The few girls who are left are quite
depressed and it is a tragedy that the leadership was unable to keep
this fine Institution going.
Thank you very much
the institute and was

I learned one fact,which should have been brought to the
attention of the public in 1962. When the Institute opened, there
were more than 2500 patients at the St. Louis State Hospital. The
Chief Nurse tells me now that their census is down to less than 500
patients, and that to fill the empty halls, they have moved aged
and mentally defective patients into the Institution. Sheltif the
public should have been told that much of that reduction, which far
exceeds the reductions in New York State with which I am now acquainted,
was the response to greater care more physicians, etc.
I was puzzled as to where I got my erroneous dates for SPR.
Please note the enclosed which led me to mark my calendar. I also
am sending you the only other communication I received which makes
no mention of a change of date.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

Enclosure

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                    <text>March

lilliem

6, l968

Martin
Director, Addiction Research Center
Dr.

R.

NIHH

Lexington. Kentucky
Deer

Bill,
I have read

thaoozogical
reprints are

your review of Opioid antagonists in
Review with a great deal of interest.

still

I look forward

available,

to seeing

I would be

grateful for

you next week.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Max

Mszp

If

a copy.

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                    <text>Jana 21. 1968
Dr. William Martin

National Institutes of Rental analth
5454 Wisconsin Avenue
Chevy Chase. Maryland

Dear Dr. Martin:

Enclosed is the next chapter in our continuing
interest in cyclazocina. Dick White was kind enough
to run those studies just before he left for Birmingham.

Apparently, cyclazocine compares favorably with iniprauino

in his model.

Sincerely yours.
Max

Fink. M.D.

Protester of Paydhiatry

MPH“)

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                    <text>July 21,

1970

Dr. William R. Wartin

Chief,

MIME

Addittion Research Center

P. O. Box 2000
Lexington, Kentucky 40501
Dear

Bill,

release form of antagonist is
13
of
clear.
letter July describes some steps which may
be necessary to test the feasibility of Sr. Yolles’ preparation.
The need

Your

for

a sustained

Al Freedman is in Europe and I am leaving on August 4.
and I will both be together again in ﬂew York after September 3
and I would suggest that we arrange to meet - with Dr. Yolles and
any other interested participants ~ during the second or third week
in September. This can best be arranged on our return.

He

you are aware that Endo Laboratories on
announced
decision to discontinue supplies of naloxone
a
July
for clinical trials. In re5ponse to inquiries from friends on
the New fork ftmes and CBSeTV, Dupont reversed their decision
and our clinical programs, despite the improhanility of its
success, will continue. A copy of “r. Serchuck‘s letter is

Incidentally,

3

enclosed for your interest.
My

best regards.
Sincerely yours,
Wax

Fink,

M.D.

Professor of Psychiatry

MF:kt
811C.

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                    <text>“cg-pm...

..

gunner... n.

w

".m‘mw...~.—m.;.

..

‘1

.r

1.1.1,;

ﬂyww .q.vv..-»,—lwm~

July 3, 1970
Dr. William martin
Addiction Research Center-

Lexington, Kentucky

.
..

Dear

Bill,

’lWlU-m.NV1'-

”Hwy-e

ea;

Following our June 4 meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
Dr. Seymour Yolles, to see if his preparation could be assessed in

clinical trials.

I called him this week and found him most cooperative
and enthusiastic about his preparation. He can make some samples available
for human trial this fall; and for animal assay now. He seemed reluctant
to deal with us directly, indicating that his supply was made under N.I.M.H.
grants, and that rightfully, they should decide the next steps. He wished
to first obtain your approval for release, as well as the permission of
Dr. Sidney Cohen.
Since you have been instrumental in setting up his program,
be
not
useful for you to assume the responsibility of’assuring
his cooperation as well as that of N.I.M.H. (Dr. Cbhen ?) to bring this
method to early trial ? Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. Yolles
the program can be implemented.
would

it

if

Incidentally, the summary of the June
the
editor of‘Science for publication.
accepted by
ﬁg

4

meeting has been

best regards.
Sincerely yours,

.
WV.

Max

.7

Fink,.M.D.

Professor of'Psychiatry

«w‘w.wv.w‘,m...

mf/
cc: Alfred Freedman
seymour Yolles

10..."..1‘

..

x

._—.

m”-

.

�</text>
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                    <text>July 3, 1970
Dr. William Martin

Addiction Research Center
Lexington, Kentucky
Dear

Bill,

meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
his preparation could be assessed in
Dr. Seymour Yolles, to see
Following our June

4

if

clinical trials.

him this
I called
about his

week and found him most cooperative

preparation. He can make some samples available
reluctant
for animal assay now. He seemed
trial this fall;
for
N.I.M.H.
made
under
was
his
supply
to deal with us directly, indicating that
He
wished
the
next
should
decide
steps.
grants, and that rightfully, they
to first obtain your approval for release, as well as the permission of
and enthusiastic
human

and

Dr. Sidney Cohen.

Since you have been instrumental in setting up his program,

it not be

assume the responsibility of’assuring
his cooperation as well as that of N.I;M.H. (Dr. Cbhen ?) to bring this
method to early trial 7 Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. rolles
the program can be implemented.

would

useful for

you

if

to

'

accepted by

Incidentally, the summary of the June
the editor of’Science for publication.
my

4

meeting has been

best regards.
Sincerely yours,
Max

Fink,

M. D.

Professor of’Psychiatry

"#7

cc: Alfred FreedMan
Seymour

rolles

�</text>
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                    <text>Hovember 23, 1970

Dr. William Martin

National Institute of Mental Health
Narcotic Addiction Research Center
Lexington, Kentucky
Deer

Bill,

Enclosed is a xerox copy of the salient documents from
Alan Corporation, relevant to their participation in the
development of a long acting antagonist. As it is unlikely
that we, alone, could obtain such funds or encourage such a
project, we would appreciate your advice.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
811C

0

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                    <text>in?”

n.—

sz-aw

-

--

*lW-mvnrv‘ ’i-‘orarw~y.-w—._..mwv~w
Isa-um)...
v

,

W... IAﬁmyrxnn’m'wm'ndwﬁ‘wl-mv4wV1-‘V‘ﬁ

NVTWv'n-l'wu‘nr'vwm'vvrnw.

v m,w

-mww-m-«aur‘w—mqwngnm "w?" r—u-w

February 22, 1971
Dr. William Martin

National Institute of Mental Health
Lexington, Kentucky
Dear
v,

”.mpnwwma...

,1."

,..7..,.,.

Bill,

Art Zake reported that the data on EN 1639 is as interesting
as you hinted last fall. Unfortunately, illness prevented my
attending the meeting, and I am writing to ask if you can make a
copy of the report available to me.
Hwy thanks.

‘uv‘ll

Sincere ly yours,

.

.

“Al-runtrw'mwwwrr-vw.

arm

.......,_.,&lt;

wwmm~mmwmwu

Max

Fink,

M.D.

Professor of Psychiatry
MP:kt

me 7-:

.

-

,-.

�</text>
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                    <text>VFVV.W75'.-r——

:w’mn'rvww-m

,

.nm

march 8, 1971

Dr. William Martin
Addiction Research Center

National Institute of MBntal Health
Lexington, Kentucky
Dear 3111 ,

I

Thank you for the report on EN 1639. It is
hope that further studies will be encouraged.

quite clear

and

Last week I appeared before a ﬂew York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur: and that tolerant subjects
were completely "normal”.
In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
cited abate?
seem

Many

thanks.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Hex

MF:kt

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                    <text>pram-www—

~xW-r-

.mwmwry'l‘

:
:‘r-v-c

mvv—‘vvy'w‘

March 8, 1971

,.,

,wr:v—2

.

_Wn&gt;mﬁrm-ﬂ"

—m

Dr. William Martin

Addiction Research Center
National Institute of Mental Health
Lexington, Kentucky

r..-,—&lt;.,—q

,—

vmzme’r‘wmwv-W‘

f

wry-""5

~—~

:
g—

.—

Dear

I

Bill,
for the report on
that further studies will

Thank you

hOpe

1639. It is
be encouraged.
EN

quite clear

and

Last week I appeared before a New York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur; and that tolerant subjects
were completely ”normal".

.mrwwr—r-w

.

In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
seem

cited abate?
Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>October 31, 1966
Dr. B. L. Martz, Secretary
The American College of Clinical Phannaoology
and Chemotherapy
230 Nerth Broad Street
Philadelphia, Pennsylvania 19102
Dear Dr. Martz:

It is

for your kind letter of October 25.
a pleasure to join the American College of Clinical

Thank you very much

Pharmacology and Chemotherapy.

Please be advised that as of July 1 I left the University
and am now Professor of Psychiatry
the New Ycrk
Medical College. my new address is 5 East 102ndat
Street,

of Missouri

New

Ybrk,

New

York 10029.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

13ka

�</text>
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                    <text>"a,

A?

k.

w

'—‘&lt;\-

«

’xﬁwaésc'.Irﬂ'J—urrrr

v

u.¥am',

,—,\.r,-.x:-:;;-.,w

frmmmn,gt.r =V~-—-——r,— 1-".i

H

,

JV.

,,

1,

.

,

,,

‘

imp _,,,___,,,

V

.,_..;V(‘.,.,m

7. ﬂag “w
7

”5?“,TFVR, ,TW‘L‘LN

March 31, 1987

Robert Martz, M.D.

Group Director- CNS Diseases
Du Pont - Medical Products Department
Wilmington, Delaware 19898
Dear Dr. Martz,
I thought that I had sent a copy of our response to the FDA regarding 1ND
21,821 to you, but I may not have.

in response to a request from the FDA in June, 1986, I noted our failure to
EEG or the behavior of our psychiatric patients during the course of
convulsive therapy by doses of naioxone up to 20 mg. As our findings were
consistent with other reports, we discontinued the study. We have not published the
results of our experience. The remaining supplies of naloxone were outdated and

affect the

destroyed.

Copies of our formal notiﬁcation of the FDA and their reply are enclosed.
Thank you very much for your cooperation and assistance in the study.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

_

4“

..

,

..

.

.

�</text>
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                    <text>MM

December 18, 1993
Ms. Lynne Mascarella

CME Oﬂice
U. Arizona Health Sciences Center
Tucson, AZ 85724
Dear Ms. Mascarella,
I am pleased to permit the use of my report in the Acta Psychiatr Scand.
for your CME course in February.

The ideas in that report have been updated, however, by a presentation in
Paris in January. That report, titled “Optimizing ECT” is now in press in L ’Encephale. I
enclose a copy for your use, suggesting that this draﬁ is more up to date and of greater
interest to your students. The main point of difference is in the thorny question of whether
repeated threshold determination is necessary or indeed safe.
Good luck in your course, and my bets regards to Dr. Gelenberg.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>July 9, 196‘

Massachusctts Institute of Technology
Raauatch Liberatory of.Elactron1cs
Docuunnts Room
Cambridgn, Masanchuscctc
‘

Gentlcnnn:
Uh

would

greatly appreciata rccalving a

chort £13.
in; syntcm?

copy of your Technical
multichannel clcctroencephnlographic tclcnnterby F. T. Kambrocht (1963).
”A

that coopnrscion 1- appreciatqd.
Sincerely yours,
Ha: Fink.

Director

HF/jb

M. D.

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                    <text>w:

mnvrm

Karen 19. 1953

Wan-W's

2-,:

”Wyv‘vvr-wr’nzuw

Rollo

-116;

H. D.

Secretary-Treasnrcr
York neurolagicnl Sociesy

New

—.:-.-W——~,,ww

700 west 168th

n—
‘

—

'I’WD-

J. ﬂasnulink.

"

Haw

Iark 32,

Street

How

York

Dear Dr. musseling:

It is

with regrct that I submit this lottcr at
York-Eaurolagical Society.
“During the past year I have waved to St. Louis to
datuhlilh this research center.

~“'71'5‘],rui.¢1m1z1omfrmathe New

I am grateful for thn opportunity to have participated in the yrograma of the Soe1¢ty.
Sincerely yuuru.

ﬁr-wr

-In!-

11.”,

,w...

w
«

ﬂux Fink.

mm.

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312.330:

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��</text>
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                    <text>October 28, 196‘;

Jules Meeseman,

Md).

(human, Program Camittee,
303 B. Chicago Avenue,
60611

mioago, Illinois
Dear Dr.

-

Moscow:
Late last

month my associates and I submitted
the abstract entitled "Relation of Drug Induced Dissolution
of Cortical Electrical Activity to Peyehopathological
hormone" for your omsideration for the 1965 meetings
of the American Psychiatric Association. The work in this
pmgmhcsgomlowell endthe reporthas alreadybeen
written, so that we would like to sunnit this for pub—
lication in the innediete future For this mammand
to abide by the general principles of our associatim. I
should like to withdraw this abstract from consideration
for the 1965 meetings.

you.

I trust that this action
Thank your

does not inconvenience

for your cooperation.
Sincerely yours ,
Max

Inf/ls

Fink, Md).

Director

,

�</text>
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.0

..

""77

-7

,

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9 May 1973

John

J. Belliani. J.

D.

8! State Bureau of Hercotie Control
835 Central Avenue

Albany,
4

New

Dear Mr;

York 12206

Belliaai:

licensee for reeearch in schedule I and II to V drugs, as wall
as an invert certificate for schedule, at my office at 5 East 102 Street
in New York City. I transferred cone or my work to a new location at the
State University of New York at-stony Brook, and since February I have

I hold

BEBE

attempted to Obtain certification here.

for certification at a second address, we
notified belatedly that examination by your office was prerequisite.
reconsted examination by your office and early in April, your representav

After filing requests to

BEDD

wore
we

tive,

Mr. Conaolino examined

application forna

When we

order,

our location and kindly completed the necessary

on April 13, 1973.

enquired of him, on April 26, he indicated that the papers were in
deliver them to the appropriate agency in Albany on

and he would
Monday, April 30.

not hearing from your office, I called him today and was told that lie papers
have been forwarded, and that I should hero patience. In checking further, I
called Mr. Leonard Valeria, his supervisor, who indicated that he indeed
would have to approve the applicatiOn, but that the application had not
reached him as yet, and that I ahonld have patience.
Considering the excellent reputation of your office for efficiency, I am
surprised by this delay and I would be grateful for any assistance you can
give no in obtaining the necessary certificates. Our work has been delayed
many nonths, by our desire to abide by the law.
Many

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M. D.

Professor.of Psychiatry

Manpv

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                    <text>septenbar 23. 1963

Jules

H. Masseman, M. D.

Mariam Paydxiatric Assoeiatim
3% East Chicago Amman

mime 11, Illinois
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.W. ﬁw—nw—w—W ——r‘m——Iwm“~mw~

December 2, 1969

Jules H. Hasserman, M.D.
Editor, Current Psychiatric Therapies
Dr.

South Michigan Avenue
Chicago, Illinois 60603
8

Dear Dr. Masserman:

pleased to enclose our manuscript ”Treatment
of Heroin Dependence with { iate Antagonists” for
publication in Cunncnt Paycaéatmic Thenapéeb.
I

am

I

regret the delay

toogroat

an

and hope

inconvenience.

that

it

has not caused

Sincerely yours,
Max

Fink, ﬁ.D.

Professor of Psychiatry

Mszp

�</text>
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_,

~-

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December 29, 1976

Ing.

M.

Matejcek

Sandoz Ltd.
#002 Basel, Switzerland
»

Dear Matejcek,

I was pleased to receive the enclosed inquiry and as
I answered the many questions, I became more enthusiastic; hence
this letter. Many years ago, in 1968 and again in 1969, I organized
meetings in my laboratory in New York. I remember a session at
which Creuzfeldt came and argued very logically for more basic
studies. At the time, I ignored his comments, but lately that
need had become all the more apparent.
I know that some workers are occupied with the technical
issues of electrodes, EEG reduction methods, etc. But these issues
have been solved, to some extent, and what seems to be needed, are
studies relating the EEG changes to behavior. The diagnostic use
of EEG profiles to define new drugs has been successful; some
applications to pharmacodynamics have been interesting; but we
lack the understanding of the significance of fast waves for
behavior for example. Past waves increase after barbiturates
(sedatives) and thymoleptics. Are the chemical changes in the
brain the same or do these same rhythms reflect different chemistries?
Or, as is also likely, we have not yet resolved the differences
in the fast waves after barbiturates and thymoleptics ? Further,
of what predictive value for neurohumors are the EEG changes.
We know that anticholinergic drugs elicit the same BEG effects
as the thymoleptics. Does that mean that thymoleptics act via
a reduction of acetylcholine in the brain ? And so on.
have struggled for years to have pharmaco—BEG recognized
At the ACNP, for example, each of the early years
was marked by an BEG symposium, but these became redundant and
the memebers disinterested when we failed to show the scientific merit
of the work. At times, the data has been presented at psychiatric
and at BEG meetings, but these disciplines are interested mainly
in the practical uses, and ever since psychiatrists decided to ignore
the sedation threshold work of Shagass, Goldman and
they have
We

at major meetings.

Itil,

.

-..

v.

_ yum-“1......—pg,» .-

�..........December 29,

Mr. Maeejcik

1976

..... ......

page

2

ignored the new developments in EEG and drugs. I think that
meetings should be held independent of the main societies, and
related th them mainly for the convenience of timing and the
reduction in expense. Surely, meetings should be organized
alternately in the U.S. and Europe, perhaps in Asia when the
opportunity presents. If a meeting can be held in a working
laboratory, then it should be held there-- giving the participants
a chance to see the facilities and ask questions regarding tech—

nical issues.

Society should be organized formally, with rules and

The

by—laws

to privide

he graduated.

some

continuity

and some dues which could

The restoof the answers are on the form. Perhaps the
meeting could be held in Amsterdam at the International
EEG In September 1977 ? With a visit to Paris at the time of
the course in EEG to Btevenon, or to Basle ? ? ?

first

My

best wishes

Ma

healthy and a successful 1977

.,._.,-r

Sincerely yours,

Pink, M.D.
Professor of Psychiatry
Max

I

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October 28, 1978
Mr. Milan Matejcek

Sandoz Ltd.
h002 Basle, Switzerland
Dear Milan,

I received your letter dated September 22, I arranged
redrafted and I believe I have followed each of
to
the instructions but one. I would appreciate your translation of
the abstract into German, to meet the standards of scientific
When

have the paper

translation.

The only question from your second letter that is confusing
of
is that the designation of left occipital-vertex leads according
to the International (10-20) placement. I enclose a copy of the
drawing which we have used for a number of years, which indicates
that 01-02 is correct for left occipital—vertex leads.

Please excuse the delay which
during the past month which have taken
Atlantic a number of times.

was occasioned by my
me

travels

cross contry and cross

I look forward to the publication. In the meanwhile, I
have put my hand to a draft of a report on clozapine which still needs
much work. I will send you a draft when it is available. I am becoming
convinced that our EEG profiles are more compelling, in the light of
the ancillary clinical and pharamacologic evidence, that the clinical
Judgements that clozapine is an 'antipsychotic' are probably wrong.
It is indeed unfortunate that clozapine has been withdrawn for in
the clinical marketplace, it is likely (I believe) that the practitioners
would have rejected its antipsychotic designation and found its utility,
which was seen
if at all, in depression.andThat was the fate of doxepin
of
experience, was
the
marketplace
only in
first as an anxiolytic,
EEG
had
designation
determined
the
(after
its antidepressant activity
been made, I must add.)
My

regards.
.

x

Sincerehy yours,
\

\
1

\

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>May

7, 1965

Iwm

:4
«-

“'1‘!

""V-

‘

m

w-w-nwwv

Mr. Milan Matejcek
Sandoz A.G.
CH—h002

Basel, Switzerland

VII"?

”9‘"

mu

«raw-w»,

Dear Milan,

For your examination of the EEG effects of ngptropic drugs,
you mmyujﬁgrto write to Per Mindus (Department of Neurophysiology,
Karolinska Institute, Stockholm). I understand he has some reports
on piracetam which are inconclusive.
My

best.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MFzsl

�WI
WHOM
1’

May

5, 1980

Mr. Milan Matejcek
Sandoz A.G.
CH-QOOZ

Basel. Switzerland

Dear Milan,
have never developed a special program of analysis for
'nootropic' drugs. In our work, we have taken compounds of different
structure, and sought to assess their EEG profiles against the known
active compounds for different mental conditions. In the absence of
any effective compounds for the alleviation of the memory changes seen
in the elderly, we have not been able to define a nootropic profile.
I have enclosed copies of our most recent reports, including the summary
We

wv

wr~m.7.

..

W.W‘~:v;wvw

'v

"W".

V“

New:

-

v-vnn-vn

vuwny

mu“

'
w

5

.mpsz

111'

-

""WWNIW'ITM

"WW1

’rwmwr

prepared for the

1978 EEG

congress.

two occasions, we analyzed tapes prepared by others in their
study of supposed vasodilators. These reports were negative, but I enclose
copies of the data summary for your information. While these are unpublished, you may quote them if you wish as personal communications.
On

that the evidence presented so far,
for a definite profile for a nootropic class of drugs is unconvincing. I
have yet to see a definite report of either EEG or clinical activity for
piracetam, and the data for other such agenst is equally weak. In a
similar vein, we have been uanble to define activity for the fragments
of ACTH and it is unlikely that the slight behavioral effects will have
As

any

when

an opinion, I would say

clinical utility.

it is

Good luck

completed.
My

in your review. I look forward to reading a copy

best regards.

W
a
.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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Mathatronics
257 Crescent Street
Waltham, Massachusetts

021514

Gentlemen:
We are interested in purchasing an electronic desk
calculator and would appreciate descriptions of your
equipment, appmcimate prices in New York and the name
of a local representative.

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MP:kp

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Hum,ofmm
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Mrs. Him

mo

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m1Miami.

1.0118.

63139

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mmmmmmmmxmmmmm
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                    <text>Novanber 17 , 1966
Mrs. Nina matheson

Missouri Institute of Psychiatry
SHOO Arsenal Street
St. Louis, Miami 63139

DearNim,

AaIInvemtbeenmoeivingﬂixisjmmul,Ipmm
3. If not ’ please
youhavebeenside-tmckingthcop

write

Wytompmuam.

Sincerely yams,

Pm,
m
Professor of Psychiau'y
MOD.

�</text>
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                    <text>September 8, 1967
Mrs. Nine Matheson

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Nina,
During my few visits to St. Louis,Dr. Itil worked me
so hard thtt I had no chance to visit you. Houever, I did
meet Don Sundlend and was pleased to hear of your project.

Recently Jovan Simeon shared with me one of your monthly
envelopes and I was pleased to find at least four articles
interest
that I had not seen before and which were of further
extend
be
your
possible to
to my present program. would it
service to an ex-Missourian?
My

best regards.
Sincerely yours,
Fink, n.0,
Professor of Psychiatry

Mex

Mszp

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                    <text>mwrnaviawlﬁ

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7r0€tober 6, l967
Mrs; Nina Mathesdn, Librarian-l
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Levis. Misscuri 63l39

'

'

Dear Nina.

I.was very pleased to receive your letter. and I found a"
review of the cancapt lists most interestthg.
,The concept

numbers and titles that reflect my present interests
are
enclased. and except for a fnw places where l was unclear

ihcluded each descriptor) I believe as
these‘
are‘sufficiently specific to limit'the number of titles which
to distinctians (so

.

will

be

I

sent;-

.It is clear that this system is dependent on the
of the coders. and you must be callecting'valuable dataability
as to
the qualities necessary for subh‘work. QOur own system broke
down when we required the
descriptors frOm the
and
than checked them. Nevertheless I.look ferward scientists
to seeing the
output from year system.Since returning to New York have deleted my timé to
'reestablishing the computer~EEG facility (it is now operational
and a second EEG laboratory will be completed this month);
the
clinical research units (there are three ~ an 0P8 unit fer new
drugs; a 25 bed in-patient unit for narcotic addiction; and a
25 bed unit for acute mentally ill and new
treatments); and the
psychopharmacology teaching pregram. ~I have had no time to re»
establish the library programs although we have the HIP—EEG
cards in duplicate and I hepe to put a programmer on the problem
wI

.

soon.

'

‘

,

it

~

'

.

L

W'in-uci-WJHU'

�w.“

1",.”

1...“.

my.» my

“mp-..“r-yuv‘ug- vcn:«rwmwm: nu. ~muvwra-m1.

.

arm"

l“

Mrs. Nina Matheson

«2-

October 6, 1967

Having the Academy of Medicine around the corner has been
of help. I now have a iibrary card that permits me to visit in
the evenings. But time is stiii short - even less than in Missouri
and so I have to depend on the journals that cross my desk, and
now, to your 591.
Many

thanks again.

And

give

my

best regards to

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mlep

Don.

~

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                    <text>r“van-w n m;W
&gt;

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-

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q

T

vamvmwwgaw.” 'I.

Mrs. Mina ﬁatheson

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Nina,
few visits to St. Louis,Dr. Itil worked me
so hard that I had no chance to visit you. Houevor. I did
meet Don Sundland and was pleased to hear of your project.
During

my

Recently Jovan Simeon shared with me one of your monthly
envelopes and I was pleased to find at least four articles
that I had not seen before and which were of further interest
to my present program. Would it be possible to extend your
service to an ax~Missourian7
My

best regards.
Sincerely yours,

via".

-.

'1er;

~4i—O‘J

Fink, M.D.
Professor of Psychiatry

Max

m

"-*'-"'“-Ww&gt;i

:ru-w

WEN-W

~

September 8, l967

now-Mag...”

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                    <text>April 8, 1968
Mrs. Nina Hethlson
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Nina,
I have

appreciated receiving the citations from the

Project. So-far, my principal criticism would be that
many articles are sent from journals which I regularly read
and this duplication may be expensive. Perhaps, in future
systens a check could be introduced not to send certain
SDI

c

tat ens.

‘

other group of citations which are of less
interest are those related principally to studies in animals.
The only

I have examined

assigned to

profile.

my
. 38 and 41 may be
applicable to my
Many

the

list

of

new concept numbers and

I would suggest

deleted. This will

present interest;

make

that

numbers

the profile more

thanks.
.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

those

la, 32,

�</text>
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                    <text>Aux-=-

7383—83883
20 December 1973

Jovan Simeon, M.D.
Missouri Institute of Peyohietry
shoe Arsenal Street

Saint Louis, Miesluri 63139

Dear Joven:

I am pleased to cooperate with your date analyser and
look forwerd to receiving the cards.
As I mentioned, this Department is growing
very repldly.
here been notified of Federal.ewerda totaling more than
$1,000,000 for the coming year, in training and research, in
drug abuse, and in the peyohopothology of sex. It is highly
likely that this Department will be awarded e special grant
from the State to establish e research center similar to the one
in Missouri at the local State hospital. we eleo have the pos—
sibility of expending the program in mantel deficiency and
retardation at e local State hoapitel.
we

Recognizing your background, I took the liberty of dis—
cussing your credentials with the Chairmen or the Department,
Dr. Stanley Yolles. He would be delighted to here you visit.
Should you be interested in relocating to Rev York,

I

suggest you write him a letter telling him of your interests
end submitting a curriculum vitee. Your letter should indi~
cote that you are well known to myself and Mickey Taylor, who
in now the Director of Residency Training for the Department.
If you happen to know Joe wortis on well, I would indicate
far he is in charge of the mantel retardation program here. that,
My

m

best regards fOr a

happy and healthy lQTh.

.

Sincerely yours,

‘1'“:

«

«wpag—w—wr—vr

Fink, M.D.
Professor of Psychiatry
Mex

MF/ois

�</text>
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                    <text>.

"me'JF'I-wawwrv

w‘r—Awry-I-

7333-82433

20 Decambcr 1973

Costco Stefania, M.D.
Deparcutnt of P:ych1atry
Untvaraicy of Achcns School of Modicina

Bainition Hospital

76, Vasillilais Sophia Avenue
Athena . Gram
.

.
.

wrwgrgnmqgmw

Boar Cactus:

In chanting the informntion of ch: withdrawal data, an lack
tha drug node (a: Evnnaclidis and Ermidil. Can you pleas. tell
as tho code (A or B) for Station- 1~3 and 4-6 for each of abuse

MM

Many

,
a

thanks.

m
a",

Sincuraly yours,

Emma»

by

.
l"—

‘

HI: Fink,

'jt/‘rﬁf‘yy

lF/cia

ml

‘

‘

fijﬂ‘imr'ﬁ'v

»-4"'"',"W4¢:mi.fﬂ'

-'
{“91

f
TWWW“:

1-f-

f"
.1“?
‘

qsv

M.D.

Pro£0500t of Psychiatry

.3:

0

�</text>
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March 10, 1971
Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

1014 Hoe Avenue
Bronx, New York 10450

Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.
Good luck

in your efforts.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
8316.

-

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10, 1971

Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

WW."

Wu

-

1014 Hoe Avenue
Bronx, New York 10459

._.

a.

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Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.

‘rnwe—

Good luck

..

in your efforts.
Sincerely yours ,

wwwprx..-‘

nan-p

"a."

Fink, M.D.
Professor of Psychiatry

Max
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v...

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A

20 September

a-n-v-v-wwnwww-wn1—.mw~.v.u—-v-.~’-..-«.murmur—“v

ww.w.-rn

PD

l97l

Dr. N. Matussek

Max

Planck

Institute

Munich. Germany

Dear Dr. Matussek,
I have been asked by our National Institute of Mental
Health to organize a meeting on the general problem of the
biochemical and neurophysiologic data of induced seizures. in
man and animals, with specific reference to electroconvulsive
therapy. In discussing the work from various laboratories. some
of which may be unpublished, your name was suggested as one
to whom I may write for information as to work in progress.
I

work, or

would be

grateful for

any infbrmation regarding your

that of your co-workers. that is ongoing andmight

on the problem of electroconvulsive therapy in man. I
should be particularly interested in any preprints of your

bear

recent work.

spring,

The

conference, should

1972 in the United

Thank you

it

States.

be held.

is planned for late

for your reply.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

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                    <text>rww—m

——--w-.

,

wwmmww—wwmeurwum

i
g
'5,

r
E

é

January 14, 1971

E

Mauna Kea Hotel

Hamenala,
Hawaii

Gentlemen:
We are planning a 3-day scientific conference for
October/November 1971, for A0 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. We have not yet specified
the specific date, and I am writing to inquire as to the
availability of accommodations, and the costs, including

conference

facilities.

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Max

Fink,

M.D.

Executive Director

kt

7

Juan-J1

,

�</text>
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                    <text>7583.04583
30 January 1975

M. Bursar. M.D., D.Sc.
680 Madison Avonuo
Now York, Now York 10021

Frank

Door Frank:

I am pleased to enclose tho reprint that you roqueotcd.
will be ploasod to know that the use of EEG for idonti~
fication and classification of new psychotropic drugs in being
actively pursued in a number of industrial laboratories in
Europe. including Schoring in Harlin, Sande: in Basel, Organon
in Holland, and a laboratory in Genoa. I would be glad to discuss this work the next time we moat.

You

Best regards,

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mﬁloio

Encls.

�</text>
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                    <text>w

«cw-w"- -

.'«~r1‘:'m~"rwr.m~;wl~

W, '

,

,

,

u,

,

.

.m:

,

wavy
.

W&amp; ,

4‘q v- a.” ,Lwr

«

_,,,
.

,

_

._,,-

V

r.w-.r.~m;ru

October 20, 1967
Mr. Robert Maxym
Swarmhmnre Cbllege

Swarthmore, Pannsylvania

Dear Bob,
Thank you far your letter. Of course we are pleased
have a.mamber of our staff visit with you and share his

to

experiences.

nu:

rm

Incidentally, sinca we are not paying him well, perhaps
the Cbllege could, in addition to defraying his expenses,

pmnwide a.modest honorarium.
Good ludk!

Sincerely yours,
n;

u
m

A-_-

n’

Fink, M.D.
Professor of Psychiatry

Max

marmrz-mw.‘

MF:kp
:mpvmmwxm-mwn-mmm-aw

wry

'im'

A

m-nwnyw-rnv

.1&gt;1~rA-v

-v—n

�</text>
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                    <text>May 5 ,

Dr. Anthony R.

1967

May

Adnjnistmtive Health

Alexander Planing House
Elephant and Castle
Landon SE 1 , England
Dear Dr. May:
Enclosed

decanoate as

I

is a copy of our report
promised.

I trust

it

on fluphenazine

is helpful.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the health Sciences
Los Angeles.

Dear

Califbrnia

90024

Phil.

I want to thank you for your consideration in sending
a copy of the volume “Treatment of Schizophrenia", which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways, I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations

on a study well done

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp
'

r
M"

c’m‘

ermwvc:mtmw"rmwrv

?
,«g,

E's‘.fwx’.

r."

n»:

7—

�</text>
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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the Health Sciences
Los Angeles.

Dear

California

90024

Phil,

I want to thank you for your consideration in sending
a copy of the volume “Treatment of SchizOphrenia“, which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways. I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations on a study well done

best regards.
Sincerely yours.
Fink. ”.0.
Professor of Psychiatry

Max

Hszp

�</text>
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                  <elementText elementTextId="104101">
                    <text>‘
IV_'

{4.

i
v?!“

”mum‘s.”

-‘l."!£

..

Must I.
Philip

R.A.M&amp;y, M.D.

U.C.L.A.

~:

1979

Lon Angeles,

California

9002h

wreamatrm-“w

Dear

Phil,

.‘h'
'1‘

I was pleased ta submit a letter on your behalf for
pramotion to Professor in Residence V. I did so at the request of
Milt Greenblatt. I hope you get the promotion.
my

.vys—n

~

best regards.
Sincerely yours,
Fink, M.D.
Pgofessor of Psychiatry
Mg;

‘

.

rmi‘m‘i‘iw"’

"'

x
mar,

-—.v

�</text>
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                    <text>March

5, l970

5. Bureau of narcotics and Dangerous Drugs
l405 I Street. n.n.
Washington, 8.6. 20530
U.

Attention:

John Mayer

Bear Sir:

M

'
J14

I am writing to request 5 grams of recrystalized purified
heroin to continue our studies.

did receive l0 grams in Qctobor l969, but recently
we noted that the remaining supply has an acetic odor and has
become slightly yellowish. In checking old pharmacy books, we
find this to be a sign of deterioration which is ordinarily
prevented by keeping the supplies closely sealed and in the
dark. I regret that our supply has deteriorated. If purified
heroin is available at the Bureau. we would be grateful for
5 grams and will return our present supply for rocrystalization.
we

Thank you

for your cooperation.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

:4
at
.31..

.
)..ae_

1“

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                    <text>WP”

L‘s.“—

(r v—A»!

um

\WWA
,

,

mm-

,

,

mm“ mm“ w-Y_-an.
. », —

‘

_.

v

,. ‘ . .wm.yawma.wvnwm

"Maw“. _ . ,V »/
,

,

....~.

.9- ‘7-“

\

F

t
F

i;

E

!
k
E

E

g.

Soytenbor'BO; 1975

McAllintor, M. D.
Corresponding Socrntary
Amarienn Board of ElectrOencaphnlography, Inc.

M.

A.

.

3101 Kyle Awenuc North
Golden Valley, Minnesota 55h22
Deni Dr. McAllister,

I am pleased to-support the application of
as a qualified olectroencaphalogruphor.

Dr. Gerald Perry

I have known of his work for more than 20 yours, for ha
was Ictivn in clinical practice of psychiatry and EEG shah I firat
can: to the Earth Shore of Long Islnnd. Kb is a fin. clinician,
and an excellent neurologist; A: part of his practice, he has maintained an active interest in cliniogl EEG, being one of the principal
consultants in our community.

Lately, I have collaborated with him in a research atuay
in which EEG mcaauxes are integral, and I havn found his Hork.most
helpful and his cooperation axeellant.

I

recommond him

vighout resorvution.

Sincerely'youri{*'
Fink, M. D.
Professor of Psychiatry

Max

MF/mr

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