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                    <text>Hay 31, 1966

Wendell R. Lipton-rt, 24.1).

Chief of Research
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October 11, 1976

Morris Lipton, M.D., Ph.D.
University of North Carolina
Chapel Hill, North Carolina
Dear Norrie,

I am working on a project involving dietary factors in
hyperkinesis; In talking to Judith Rapoport, she told me that you had
chaired a committee review of the Feingold and other hyptheses for the

Nutrition Foundation.

we

...

my

a copy

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Is the report published
Thank you

If not, is it possible to obtain

?

for your advice.

Now

that the chores for the

are over, perhaps you can get back to more
My

self satisfying

regards.

W'HV

yaw-aw,

Sincerely yours,

1ym"m.

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Fink, M.D.
Professor of Psychiatry

Max

work.

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                    <text>»-

7,.

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December 1’4, 1987
Morris A. Lipton, M. D.
Deputy Editor, American Journal 93 Psychiatry
1400 K

Street, N. W.

Washington, D.C. 20005
Dear Morry,

It was a pleasure to talk with you in San Juan. On my return, I read the
letter by Lieber on the "Treatment of Rapid Cycling Bipolar Patients"in the latest
issue of the 5.13. The letter recommends complex polypharmacy as a treatment of
therapy resistant depression. But the letter gives no data as to patient characteristics, history, in-patient or out-patient status, assessment of efficacy of
treatments, trials with established treatments, Egg. The letter seems to be a
throwback to the old—fashioned testimonial which modern psychopharmacology
eschews.

letter is published in the Journal, it suggests that the practice has
review
standards of the Journal and the Association. Do spontaneous
met peer
in response to an article'in the Journal, meet the peersubmitted
letters, not
review standards of Journal articles? Was this letter reviewed by any of the
acknowledged psychopharmacologistsof the Board of Editors? If yes, is there a
message in the letter that our attitude to polypharmacy should change?
As the

if no, would you consider soliciting letters to argue against the adoption of
the Lieber recommendations until they have met established standards of study for
efficacy and safety?

a fact of practice, as we often read in the
which
records
come our way, polypharmacy is not generally condoned
malpractice
by our experience or by our science. is the publication of this letter not a
regrettable mis-step?
While polypharmacy is

My best regards.

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

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                    <text>April 26,

19 72

ﬁr. Frank J. Liska
ﬁanager
Corporate Data

&amp;

6.

Information Services

D. Searle &amp; Company
IND. Box 5110

Chicago,

Illinois

60680

r

Dear Hr. Liska:
Thank you

Statler Hilton.

for the invitation to breakfast on Hay 18, at tbs
I look forward to meeting you at that tins.
Sincerely yours.
ﬂax Fink, E.D.

Professor of Psychiatry

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                    <text>7383~?10

June 19th. 1973
Mr. Gary Boynr.

Center ibr Studies of Narcotic. and Drug Abuse,
Nutiaaal Intuitute of Mental Health,
5690

Fight?! Lane.

Knoxville, Maryland 20852.
Dear Mr. Boyer,
A: V! have discussed, w. are studying the effects
of unrijunnu inhalation in ahronia hashish “sure in
Athcna, Greece. undnr the ntudy pwogrwu 38M h2~70~98.
Our luﬁclt pw¢3e¢t, thrlnl;$eﬁ in conjunction with Dr.
Btnvt saarn of HIMH,1¢ : study ef’th¢ errant. or scuxe
withdrawal in those nan. Boasuua we ﬁbula like to limit
the tint If snaking, and haeanao than: man have a high
auarec of toleranoc such thni thay achiave noun satisfaction
only when they htvo snakod 120~180 as equivalent TEC-A-9
hashiah,¢r unrisuaaa. we are reqnnnting n supply of mnriJunna

vith a high aoneontration of wao~A—9. Ehia will permit us
to have ﬁns subjects snake within a 20 minute smoking

period and coneeatrntn our behavioral and phyliolosieul
observation: under’gontrullcd eanditioas.

I an enelaning a BNDD order for: 2220 far 500 grnas
nuriaunnt (2.5} wﬁcmbp9‘oqnivnlont). It in my intention
to trannship those ta tn: university of Athena under an
‘import permit that Dr. Stefania has recoivud. and with an
export license which I an requesting eoncurrent with this

letter undar
Iehedule I).

my BxDD

rogiatration

PF0100759

(exporter,

ihank you very much for your gocperation.

Bingercly yours.

Fink’ ”.90
m
Profousor of Psychiatry
MF/iJ
En” ‘

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                    <text>October 3,

19 83

Dorson Liss, M.D.
Chairman, Special Procedures Committee
Good Samaritan Hospital
2425 Samaritan Drive
San Jose, California 9512!;
Dear Dr. Liss,
The literature on maintenance ECT is not reassuring. The principal studies
in my book on ECT (Pg 207). The APA Task Force was unable to find
detailed
are
satisfactory data to allow a recommendation, so reference to such studies was
included among the research needs in the Task Force Report.
This question has been asked by a number of other respondents. The best
suggestion that I was able to make reﬂected the present practice on my service at
University Hospital. About half our effectively ill patients who respond to a course
of ECT are discharged on maintenance drug therapy, usually imipramine, less often
lithium or phenelzine. When such patients relapse, and recover in a second course
of ECT, we then consider discharge on maintenance ECT, initially recommending
weekly treatments for 2 to 4 weeks, then bi-weekly for a month. We have not
treated a patient beyond 6 treatments as an out-patient, always trying a second
course of a maintenance drug trial. I am not satisfied with this experience, and did
propose a study which was not approved by granting agencies.
would be grateful for a copy of your recommendations when these are
adopted at your hospital.
I

Thank you for your inquiry.

Sincerely yours,

Professor of Psychiatry

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                    <text>June 10, 1993
Dr. John Little

H&amp;CS
Lakeside Hospital
Gillies Street
PO Box 63 Ballarat 3353
Victoria, Australia
Dear Dr. little,
It is not clear why you sent the proposed guidelines for ECT to me. The best U.S
guidelines are those proposed by theAmerican Psychiatric Association Task Force in its 1990
report Electroconvulsive Therapy: Recommendationsfor Treatment, Training and Privileging
(APA Press, Washington DC.) or the 1992 text written by Richard Abrams (Electroconvulsive
Therapy, Oxford University Press, 1992). Both contain the present consensus in the US.
regarding all the questions you summarize in your report.
I attach some speciﬁc comments on your document, which may be idiosyncratic with me
and my team.

There is no experience to warrant or justify any speciﬁc decisions regarding pulse width or
frequency in treatment efﬁcacy. Swartz makes claims about duration, arguing that some brief
pulse trains at 4 to 8 seconds are more eﬁ‘icient (more effective?) than the short trains of the
MECTA. There is evidence that total energy (mC) is a factor in efficacy when unilateral electrode
placement is used. For my part, we are dedicated to the THYMATRON device which allows
changes in energy and duration. When we use the MECTA device, we use the SR—2 as the more
facile of the MECTA devices.
In the US, it is no longer acceptable to undertake ECT without EEG monitoring; we
would no more think of unmonitored ECT than we would think of unmodiﬁed (no anesthetic)
ECT.

�Page 2
I have not been to Australia, and would probably be pleased to come if the arrangements

were suitable.

Much of what I know about modern ECT comes from articles in Convulsive Therapy, the
quarterly journal now in its ninth year of publication. I do not think you know it in Australia -perhaps you could subscribe and educate your peers.
Sincerely yours,

Max Fink, MD.
Editor

�Page 3
Electroconvulsive Therapy: A Medical Guide
page 1: In discussing theories, why not cite the neurohumoral and the GABA-ergic hypotheses?
These are detailed in Convulsive Therapy (vol 5, #3, September 1989).
page 2: Why is catatonia cited among both psychiatric and non-psychiatric reasons for ECT? And
what makes the non-psychiatric 'controversial'. For catatonia, if benzodiazepines are not effective
in a few days, ECT is clearly justiﬁed even in catatonia secondary to systemic disorders (lupus,
typhoid, NMS).
The contraindiCations are not consistent with the APA discussion. We no longer accept
any absolute contraindication. We now approach each case with a risk/beneﬁt analysis, and if ECT
is commanded by the psychiatric conditon, no systemic condition is seen as a contraindication.
page 3: ECT was not the ﬁrst effective treatment for mental illness; it was believed to be effective
for dementia praecox and that was its novelty.
Inanition and manic delirium are conditions that should be added to the list.
We would not accept the statement that the anesthetist decides whether a patient is ﬁt for
ECT. That is the psychiatrist's decision; the anesthetist is to do his best with what is given to him,
much as he has to do with traumatic or non-elective surgery. (When ECT is compelled by a
patient's illness, it is not elective.)
page 4: It is too sanguine to say that permanent brain damage does not occur. At times, as a result
of poor techinique, a prolonged seizure is not recognized, an airway is not maintained and a
permanent dementia ensues. You can say that 'permanent structural brain damage does not occur
under usual treatment schedules'.
page 5: A common problem is post-seizure agitation or delirium.
For consent for ECT, we usually insist that a 'signiﬁcant other' to the patient consent as

well as the patient.

�Page 4
page 7: I believe fractures occurred in T10, not T5.
Pre—oxygenation does not reduce the seizure threshold unless you have evidence not in our

literature.

The eﬁicacy/ energy relationships are restricted to unilateral electrode placements.

Brief pulse currents produce less cognitive impairment than alternating currents.
page 9: I cannot believe you mean 2780 amperes -- perhaps milliamperes? Any reference to the
electric chair in an ECT document is pejorative. Delete it.
page 10. AT this late date, you cannot be serious in stating that the observer can tell when a
seizure starts or ends in ECT when patients are effectively paralyzed and asleep. In our studies in
1980-81, we showed that cuff monitoring and EEG monitoring were essential. By 1987-90, we
became convinced that EEG monitoring was essential, mainly as a protection against missing a
prolonged seizure.

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                    <text>Felruary 10.

Bar. Robert B. Livingstm, Chief
General Research Support Brunch

Divisim of Research Facilities and

Rational Institutes of Health
Bethesda, Maryland 2001»

196%

Rams

Dear Dr. Livingston:
The Psychiatric Research Famum of Miami is a men-profit
corporation established to support the research activities of the
Missouri Institute of Psychiatry and was awarded the follcwing research
wants dwing the period July 1, 1962 to June 30, 1963.
‘

m1

MB

07071-01

Effects of diffemnt

07072001 Survey

af

NH

drug use

group behavior

period beginning Juna 1,

in a state

ital gariatric

1962

population

Wt
072159-01
and hm
$27,565
Wt period beginning October 1, 1962
$19,886

NH

trmquilim on

Wt

$19,188

EEG

period

.

‘

1):prth

07u32-01 Behavior changes with induced

Gmnt

$20,710

wind

September 1. 1962

altered brain function

beginning January 1. 1963

mm is $06,307.
In «mining the eligibility of this inatitution, I would be
grateful if you would consider the followdng facts. The Miami
Institute of Payohiatw was mated by the Governor in Jar-3m. 1962,
and was «M with an initial mating budget of $300,000 for the:
1062
1060. This sun of
of
was
Jme

The mm

period

of

January 1,

to

30,

my

�Dr. Robert B.

Livingstm

February 10,

2

196%

exclusively devoted to the monarch program of the Institute. The expmditms
included salaries of new pummel, equipping tho laboratories and beginning
the numb promos. For the biomim beginning July 1, 1963 the sum of
$338,990 was

warm.

airing the initial year of operation of the Psychiatric Research Foundation
the Institute, a nmaber of monarch 3:10ng wore begun and applications
were mach to NIH by June 1, 1963 for oonsidoration by the October Comoil.
have already bean approved effective January 1, 196“ for an
Four
eddit?ago sun of nagqao for this year. (See Appendix I).
Appendix II is a oopy of the current Intoml Remus: status of the
Foundation. The Foamdation was gramme! a
axe-pt status in
and

tow

Fomuary, 1963. An application is now pmding before the Internal Revenue
sowioo for a permanent omption (Appendix III) .

Psychiatric Femoral; Fomdatim of Hisaom is a nonaprofit corporation
its own Board of Directors. The Executive Dimctor of the Fomdation is
the Director of the Missotmi Institute of Psydaiatry. mo Pomdatioo was
mated with the approval of the Governor and the Director of the Division
of Mental widowed. Dr. George A. Ulott. Dr. Ulott is Vice President of
the corporation.
The

with

the power to Operate on the promises
Missouri
Institute of Psychiatry and supervises all pants and
of the
awards of the Institute peroaml. The scientists appointed to the Institute
appointed to the Psychiatric Research Fomdation.
are
The corporation has been given

may
The

Psychiatric Reoeamh Fomdation does not

laboratories or research

own

does own mvoable equipment made available either through
facilities, but
NIH
funds of the
or some private dmoro. Tm byulawo of the corporation
require that in the event the corporation is disaolved, all the equipment
will be made available to the Mesouri Institute of Psychiatry, at public
body.
.

Since tho Fomdatim does not om

research All of the studios are

done

or other institutiom of the Division

facilitioa, it does not com; out
at the Missouri Institute of Psychiatry

of. Mental Diseases

of Misaowi.

the emoeptionof using its funds for research at the Missouri
Institute of Psychiatry, tho Fomdation does not disbumo funds to other
organizatims to do research in tinir facilities.
With

'

I trust that this hfomtim is sufficient to make possible a favorable
determination. It is the intent of the Dimotor of the Division of Mental
Diseases to ornate a research facility in St. louis which will em out
many of the studies needed to dawlop a better mtal Malt}: program in Missouri.
rm its conception in Jammry. 1962, through the dedication of its facility
in October. 1982, to the present,

it has shown a rapid growth.

m1

�Dr. Robert B. Livingston

February 10,

3

swport
mm}:
new

196%

funds muld do mach to make possible the spmaoz‘mip
and the appointment. of supporting suiantista as they
become available, without the intarfemnea of the delays maimed by
application to NIH and Pomdations, or the biennial actions of the Hissouri

prom.

of

ugiﬂam.

Trunk you very

mm for your consideration.

SW13!
Max

Mfzaw

Pink,

12me
,.

em. (8)

yours.
Ho Do

Dimotor

�APPENDIX

I

Hi 08MB

Psydmpimoolow of the Lithium Ian

M 08517

Thump)!

Resistant Psychosis and

New

Drugs

Antmiats to mtidmlinerac Psymotmﬁmtics
m 072u9-0231 EEG and Hum: Psymowmlogy
Mi

08597

TOTAL

$ 19.750

38,0“0
73,200
23.936
§207I926

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                    <text>June

2!. ,

1966

Lloyd mph-r, Ltd.
36

Hubby Sqm

Immmmt

mmmm(mclof¢mate)
Imam
inﬂahmtumofﬂnmhhmlo‘hym.
mmtmformy anm‘midxingunmny
“mummmmmmuamotm
W,wmnuﬂutodmiml morphmutiealm
mmmmmnmmwmm.
Thank you

for yaw

W101.

Simly yam,

Haxﬂnk,

14.5.

Manner of

HF:)&lt;p

Psyolﬁatry

�</text>
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                    <text>28 , 1966

January

Dr. Bill woke
Coordinator of Research Twining
Bureau of Child Research
Parsons stare Hospital and Training Center
Parsons, Kamaa

W Dr. We;

Imwritimatthamqmtofm.

(1»me

inapplyirgforapredootmlmimeshipinthemof
wakesearm.

of

Mr. Galloway

joined ﬂan staff of the Missouri Institute

Psychiatryonmerl,
fifteen maths

approximately

for
ammowithm
time
he
was
this
a
Ming

196a,

.

tedinician in the mumphysiolow program . He damnatmtad
an ability to loam EEG tedmiquoa , to utilize the amputer
equipment available at the Institute and to carry out a
umber of projects related to marinara}. psydnlogy. He
had an worriding interest in operant cmditioning. Wen it
obvious that the program at the Institute were mm

hm
broad mug: to support ﬁxis intamst,

we

encouraged him

to the trainingprogram mnbeingestablished in
mly
Kansas City in this field.

m.

Galloway

is a personable

to

young man with enthusiasm

He has ability
drive.
marinaded
and
electronic
oquipoent.
Maugham
in hmdlim

and

His

interests are well focussed.

thetimwithusfnwasphasmtmdfrimdlymdmnliksd
minim inexperimnm payﬂwlogy

byhiamiccrs. Iwmldenowmgehimtooontinmhis
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                    <text>10...» r):

(.7. err-w

. .,&amp;,.,._.

..._

.V

4..

.,..

V

a.

u“

MW."

-

,

r

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,

‘

,

""?""“"""" ""-“’“-V“"“"""""“’

October 31, 1969
Dr. Simeon Locke
Boston State Hospital

Neurological Unit

Boston, Massachusetts 02124

Dear Dr. Locke:
I am honored and pleased to accept your invitation
to participate in the Thursday afternoon conferences at
the Boston State Hospital on January 15, 1970. It is
possible for me tojoin you earlier in the day. As I
understand your note, it would be two presentations quantitative EEG analysis in psychoPharmacology and drug
induced denial as an index of organic brain disease. The
order is whichever is most suitable for you. I will be
bringing 3 1/4 x 4 1/4 slides.
Thank you

for your invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

’

’W.«w-w-RT —,,;~wh- 'xnc.

,

hiw’

~

&gt;

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                    <text>August 13. 1953

W

Disposal 0mm
mm
of
coups

Granite City,
Door

Sir:

Dopot

Illinois

Hissmmi Institute of Psychiatry is a ram laboratory
m
of the Division of Mental assesses of the State of ﬂissowi.
We

for electronic equipment which is freqmntly amilsbls
Imuld
assm'pluspropertytmmwsuchasyours.
4cm:
may be
information
the
applications
to
as
spymiate sass
masonryfos‘ﬂiislmmtoobtainlistsofavaﬂabls
miss equipmsnt at frequent intervals.

have mod

Thank you

for your cooperation.
Sincerely yous,
Fink,
Director

Max

Mfam

M.

D.

�</text>
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                    <text>June 28, 1971
Dr. Bernard Loev
Smith Kline G French Laboratories
1500 Spring Garden St.

Philadelphia, Pennsylvania 19101

Dear Dr. Loev,

It

pleasure to discuss your interest in THC
derivatives and I do hope that you can arrange to make
supplies available for BBC studies this fall.
was a

visited the University of the West
Indies in Kingston to review their cannabis study program
for NIMH. I met Professor W. R. Chan and Dr. K. E. Magnus,
and they described two unusual derivates of their hemp plant
which they have isolated. Their formulae and a citation of
This

last

week, I

a similar product isolated by Obata and Ishikawa ace attached
for your interest.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFtkt

�</text>
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                    <text>October 3, 1969
Dr. Jose R. Lombillo, Director
County Mental Health Clinic, Inc.
P. 0. Box 1302

Collier

Naples, Florida 33940
Dear Dr. Lombillo:

Membership in the American Psychopathological Association
be recommendation by members of the Association. May I
suggest that you look through a recent volume of the
of the Association, published by Grune and Stratton. Proceedings
The annual
volumes contain a list of active members and you should feel
free to contact any of them for a recommendation.

is

The next meeting of the Association will be on
February 13, 14
New York Hilton and the
subject is ”Disorders of Mood and
Affect”. Non-members are welcome at a $2.00 registration fee.

at the

Sincerely yours,
Max

Fink,

Secretary

M.D.

�</text>
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                    <text>//f

-

_//’1

pecan”.

December ]S, 1971

‘Jnn'ur-r-

-

.e—r—.;mwww,w-—a.r

Mrs. Roberta London, Mg. Ed.
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590

.wmmwmw“””””

\~em.

Dear Mrs. London,
W's-"ﬁr”,

I have re-written the article on opiate dependence, under
the title, Treatment and Prevention of Opiate Dependence with Narcotic
Antagonists, and sent it to my typist, for delivery to you early next
week.
It is sent on the understanding that it will be included in the
1972
issue.
Spring,
As I discussed, it may be useful for your editors to con—
the
sider
invitation to some of the scientists interested in the
of
problems
drug abuse to your Board, and I suggested that you
consider Dr. Alfred M. Freedman, Chairman, Department of Psychiatry
of this College, and/or Prof. Stanley Yolles, Chairman, Department
of Psychiatry, State University of New York at Stony Brook. Both
these men ahve a long history of interest in the problems of drug
abuse and have maintained a balanced and theortically sound position
on most of the contemporary issues.

of Cannabis, will require
that for the antagonists. There
is so much research activity at present, that to be timely the article
should be prepared at the latest time possible to meet your deadlines.
Depending on the time of the year, you should re—extend your invitation
The

other

re-writing even

article,

Biology

more extensive than

about 10-20 days before the final deadline.
difficult to meet your request.
Good luck

It

should not be too

in your endeavor.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>February 22, 1972

M133

Roberta London

Monoging Editor
Contemporary Drug Problems
515 Oxford Street
Heatbury, ﬂew York 11590
Dear H139 London:

v'-

made, the biography submitted, and the
I nave added the latest data to the text, and the
title shortened.
N133 and the White ﬁance
report should be most timely, for the USPHSon- the
antagonists, which
SAODAP are both preparing larger programs
should be announced shortly.
The

own—mop."

“h...

.w

awn..-”

—

v

~—~w-w

corrections are

additional chores, should you docide to prepare a cannabis issue, our studies of the acute and chronic
effects, both in New York and in Athens, are most interesting.
While I am not looking for

I look torwcrd to seeing your

anwwuuy—mv—

first issue.

Good

luck!

Sincerely yours,

,

A

—».

an: Fink, M.D.
Protector of Psychiatry

-~v~mr——wmm.._

Ming
Enc.

.
W.—

A

.mmm

»

"'

mm.

-

w”-

'w-pm

-

�Dr. Max Fink is Professor of Psychiatry and Director of the
Division of Biological Paychiatry of the New York Medical College
in New York City. Since 1966, on has extensively studied the neuro—
physiologic and clinical effecte of narcotic substitutea and antagonieta in opiate dependence. and the effects of chronic cannabis use,
both in the United States and overseas.
He is a graduate of the Rev York University College of Mad~
icine (1945); is certified in neurology (1952) and paychiatry (1954)

the American Boards of Psychiatry and Neurology; and in paycheanalyaia (1953) by the William Alanaon White Institute (New York).
In a research career begun in 1954. he has been Director of Raaearch
at Hillside Hospital (New York) (195A-l962), and Director of the
Missouri Institute of Psychiatry, and Raeearch Professor at Washington University (St. Louis) (1962-1966).
by

Hie principal studies are in the neurOphysiologic (electro—
encephalographic) and clinical effects of psychoactive drugs and
coneeileie therapy. Applying computer methods to these analyaea.
he has provided theoretic models of the relation of EEG changes and
behavior in man, and of the node of action of convulsive therapy.
He

has

just edited a special issue of

Seminanb

in Pbychiazay devoted

to convulsive therapy, and will chair an international symposium on
this subject in collaboration with the Rational Institute of Mental

Healtu in 1972.

Institute of Mental
Administration, the Columbia Broadcasting
Syetem, and numerous industrial concerns. He is the Executive Di—
rector of the International Association for Psychiatric Research,
Inc. He is married, father of three, and is a resident of Great Neck.
He

Health, the
Long

has been a consultant to the National

Island.

Food and ﬂrug

�</text>
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                    <text>.

-

-

-

-*

'2'~*&lt;-&gt;~&gt;

--

mun—m

:w..w—,..wmu.w.m.w «w “n"‘m ”mm.wv—vw'v’-—q7vx~

p..." .,,-.....,.

,,_,__

a... m’lxk'ﬁw—W

1.“:r-,..,..~,~m~-_—.-..—r..~.r»w.r

Ref: 72-301N
June 23, 1972
Mrs. Roberta London
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590
-Dear Mrs. London,

with

much

first

issue of Cbntemporary Drug Problems
interest, and found much that was new to me. I hope you

I read the

will be successful.

I have read the articles by Samuels and by Hochsteeter. They
are disappointing. Both are vague polemics, hoping that drug delivery
problem.
will, in some undefined way, solve the Opiate dependence
Neither provides answers to the technical issues with which we have
how to select patients; how to deliver drug safely;
grappled——
what about spillage; what is the duration of the treatment; etc.
More important, neither gives a clue as to their view of the etiology
of dependence and how heroin delivery will serve the patient, or
even society. Perhaps the third paper is better-- I should like to
read it if I am to provide a commentary, which I will do gladly. Can
you send me the San Francisco report ?
Yes, I should be pleased to participate in a panel discussdon
on heroin maintenance. I will try to bring to it the technical issues
which seem so complex, the problem, of 'after heroin, what then?', and,
so as not to be wholly negative, some alternate solutions based on
a different view of the etiology of drug dependence. I do not know
whom else you are considering for the panel other than the well known
advocates (Vera representatives, Samuels). Have you thought of some
official points of view, as that of BNDD (Haislip), SAOBAP (Jaffe or
Kramer), NINE (Bunney or Petersen), and the Marijuana Cpmmission

(Brill)

?

Good

know

it will

luc} in your

succeed.

new

venture.

It

serves a need, and I
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>August 9. 19Y2
Mrs. Roberte London
Contemporary Drug Problems
515 Oxford Street
Wentbury, ﬂew York 11590

Dear'ﬁra. London:
The suggestions by Sennela, Hoehetetter. end the

mittee (Contamporery

Drug Problems)

Lari?

Con-

for e heroin delivery experimﬂnt

are well motivated, but they do not consider the severe practical
problems posed by the suggestions. In selecting heroin. they select
the drug with greatest risk (high lethality for dose), shortest do»
ration (requiring moat repeated administrations) and least stability.
They propose an experimental

patients

who have

delivery in

failed other treatment programx.

livery is to provide

all patients

trial for heroin

100

to

200

The heroin de~

a method of engagement, and within the

year,

are to be admitted to other treatment programs, partic«

ularly narcotic antesoniets, methedone, or drug-free.
The principel benefits of the program will be the incorporetion of a small additional group of addicts into a prevailing treat~
meat regiment (which, presumably, they bed once before

as a vague

test of the British experience.

rejected);

and

�.hm. uoberta London

August 9, 1972

base proponents cannot be
homework,

for

moving done

for besides the questions that are raised

moral, legal, and
from the

commended

historical grounds, I

would

raise

practical Ipharmccological) point of

View.

on

their

social, ethicnl,

some

questions

Heroin, morphine, methadone, and levouethadyl represent feur
compounds

(Opioidsl

they are most similar in

on a continuum:

their

patterns of physiologic and behavioral effects it man and animals.
They exuibit patterns of crosantolerence, for each can substitute
for the other, and each
achieve cos

may

be given by any bodily

raute

and

still

effects. Their principal difference lies in their dura-

tion of action, with ueroin'e effects lasting the Shortest, usually
from 3

to

6

hours, and levomethadyl the longest, from

36

to

48 ﬂours.

duration is important in selecting appropriate dosages, for
with short acting compounds, physicians have the most

difficulty in

for their patients.

Thus, in see

stabilizing rue effecto they

wish

looting heroin. the authors opt for the most difficult and most ex‘
pensive delivery system.
we

and from

it is

have had extensive experience with heroin

that experience
and

pleasant bodily effects.
and unusual changes in

recall

it's

other problems for heroin:

We

propenoity to produce a variety of unhave observed

seizures (convulsions),

heart rate, respiration.

sufficient irregularity as to lead
patients with caution.

two

stability, requiring careful handling for

a compound of low

sustained efficacy;

can

administration,

us

and senaorium with

to administer heroin in our

�Hrs. Roberto London

prevailing

A

Anguet‘S, 1972

View

of drug dependence emphasizes the

signifi‘

cance of conditioning and learning theory an the basis for etiology
and as a key

to the alleviation of the

In suggesting e here

syndrome.

i

oin delivery system, the author! disregard this
one method of

cipel advantages of

this paradigm have merit.

methadone has been

its

However, should the authors wish

repeated injections,
adone, which

select the

edninietretion, the repeated intravenous, that will

enhance dependence, should

route.

View and

why

One of

the prin~

usefulness by the oral

to engage their patients

by

have they not recommended intravenous meth-

is achieving

some vogue now

in Brithin,

and has the

ad—

vantege of a longer duration of action and less frequent administra—

tion?
Granting a successful delivery system for heroin to a select
group of

patients,

what

is the anticipated gain? That these patients

will be available for after—care programs, of methadone and cyclazocinel
If that is the real goal, to reduce crime by buying these patients to
participate in the eyeten,

would

it

not he more to the point to

more

adequately finance and increase the number of treatment programs so

that

more
The

patients

can be more adequately

reed selected by Samuel: and Hochetettcr is one that is

easy to recommend, but for

potholes.

treated?

Should

this reader.

their enthusiasm for

one

that is full of rut:

engagement not

they would consider the expansion of levonethedyl1

and

pale, perhaps

trials

es e more

�mw‘

are. Roberta

August 9, 1972

London

logical substitute for heroin
for

Don

and methadone; or

if their

enthusiasm

Quixote causes can be sustained, they coy investigate the evi~

dence for the development of a long acting narcotic antagonist.2 Such

a development has theoretic, therapeutic, and prophylactic possibil-

ities to

commend

from public

it,

and

yet is receiving the bares: of attention

authorities, while

much eneggy

is dissipated

on the pro-

motion of heroin delivery.

Sincerely yours,
ﬂax Fink,

3.9.

Professor of Psychiatry

MF:13

1.

Zaks, A.,

H.

Fink, and

i.

E. Freedman:

Treatment of Opiate Dependence.
2.

Iink, H.: Treatment
giarcotic Antagonists.

Levomethadyl

J.A.M.£., 220:

in Heinteuance

811—813, 1972.

and Prevention of Opiate Dependence with
Contemp. mug Ptoblema.

�</text>
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                    <text>December 23, 1972

Roberts London, Esq.
515 Oxford Street
Westbury, New York 11590
Dear Roberta,

I have read the transcript of the heroin session with
interest, and wish to congratulate the primary editors, for sending
me such a clean transcript. I am especially grateful that you deleted
some of the 'off the record' remarks, and in that context some of
the discussion on page 25 seems audacious, and probably should be
deleted.
.

I have translated the 'qéﬂ' designations to English; and
have typed a few lines about the use of ﬁalline-- you may use these
as you wish.

I have added a few sentences to the last paragraph, noting
would
I
that
not hesitate to support a study of heroin, either
as a delivery system or as a pharmacologic study, in order to learn
more about its effects. That should be enough, but if there is
reason to give more support for a scientific study (say, through
Yale University) and not a political study (say, through a nonscientific and non—medical agency like Vera) I would be glad
to do so.
.

I have also added a reference to the article in your
earlier issue, referring to the narcotic antagonists, hoping that
such a refernece may be used in the text or as a footnote, to bring
your earlier report to the attention of the readers. After all,
a critic who is wholly negative contributes less than one who provides
a

better vision

and

for

My

and an

alternate road towards a solution.

best wishes for the continued success of your journal,

a happy and a prosperous 1973

!

Sincerely yours,
.

"Ir

luvs”.

m

‘
{we

.
Wv'w

gu:(

w

Il‘nﬂa'fm‘

Max

Fink, M.D.

Professor of Psychiatry

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                    <text>Mr
MP9

I.

1mg

A.

6,

196%;

'

Southeast Bank of St. Loni
2301 South Kingnhigmay

81:. 10.113

Dear Mr.

10,

mam

‘

Long:-

It is with appmciatim and gratituda that I
accept your donation of $100.00 on behalf of the Psychiatric
Research Fomdation of Hissowiq
‘

Yom‘

mntributim will be cf 3mm: asistanoe

the research and teaching activities being established forin
the benefit of pemms with mental illmsses.
$11163me yours.
Max

Fink,

M. 1).

£2me Director
MF:AW:bw

�</text>
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                    <text>chmbor 22,

I.

Mr.

A. Long,
Bank

Wat

1965

President
_

2301 S. Kingshighway

9:. Louis. Missouri
Dear Hr; tang:
'

Enclg’sed are copies of the Board' a resolution
mgaming' the budget of the Hismi Instituu of

_Plyduiatry,midxmmttothnmm,
mdtha
mply which is sent-to you for your
Wows:
informtim.
‘

.

The next meeting ‘of thc Famdatian will be
lmdwon meeting on Tuesday, Jmuaxy it, 1966, at a
12:20 p.13. at the Missouri Autistic Club (1605 Washingtm,
3131:1113, Hisscm‘i‘). The aganda will, be short and
is plum! the meeting will and Mom-2:00 p.111.
V

it

Sinceme your: ,
Fink, Md).
Exemrtiw Director-

Hm:

�</text>
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                    <text>December 9 , 1965

Dr. V. 6. [man

laboratory of

mmwical
Matty
d1 Sanita

Institute Superiom
Rm. Italy
Dear- Dr. bongo:

Thank you vary web for your acceptance of our invitation
to participatu in the symposim of the GIN? in March. I would

be grateful if you would send a copy of your exeellent mview,
whim I hava just road to the Oo—daaimm of the symposim,
Dr. Philip
(The Hediaal School, Binningham 15, England),
no that we can make a proper dispositim of our tine follwing

Why
your mmt.

-

m

The pmgm is being Organized and as soon as I have
specific details. will write to you. Also, yam:- mquast for
financial assistance will be inelWed in our final request to

tthINPCmitteomdweshwldhavaamspmsefmnm
some time in
January.

I a: looking forward to your participation.

Simmly yam ,
Max

Pink,

M.D.

Professor of Psymiatvy

Wzkp

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                    <text>January 18 , 1966
Dr. V. G. Longo

Laboratory of mompeutiml menistry
Istituto Superiom Di Smite.
Vials Regina Elena, 299

m, Italy

Dearnr. largo:
plunged to confirm the invitation for
m
on Antidxolinergie Hallucinogena
your pardoipdtim in the
Dr. Bradley and

I

menu

forthcoming meeting of the CINP, to be held in Washingtm, 13.6.
on March 29 md 31. We look forward to the pmsmtation entitled
Effects
of the Behavioral and
As
there am still a few qmstims
of Atropine and Related

at the

ﬂammogmplﬁc
"WSW
mm.”
mmwilityofmofﬂnmpominvitmtoattendthe
muting, it will be a few weeks before we cm send a definitive
pmYourand tin sohodule.
for support during your stay in the United States
must
has been subudtted to the minimum of the: Program Comittee,

W
Wm

Brill and Cole. Dr. 001a has indicated that he will give
priority. However. the definitive
this must the
will not be sands for mother few weeks.
financial
that every
Plum meant the want-moo of the Prom Comittee
ten
dm‘ing‘the
be:
made
for
expenses
provide
your
to
will
effort

Dru.

will be presented during each three hour session,
alluring thirty-five Wes for each pmsentatim and discussion.
Since the dismaim may be of apocial intemst to the pwticipants,
(Ihavemadyour
ﬂumponshouldbeaboutzcmimtesinlength.
would
and
that you could
hope
deal
intemst
of
with
a great
smut-y
in tho allotted
in
man,
data
the
emphasizing
amazfze the findings,
Five mports

to midor the publicatim‘ of this
Insofar
as this subject is becoming
sepamtely.
bellow
that the association of the
we
lumingly
in
single
volm will be a valmble
work of the participants
a
in making a mwoript
and
ask
ooopemtim
mntrdlmtim,
your
The
mammript should be
meeting.
time
the
of
available at the
20 pages of text, plus bibliography and illustrations.
The CINP has permitted us

swim Want,

Wtely

�Dr. tango

I

do

«2»

January 18, 1968

not believe that the mpublioatims of your review

would be as helpful as a sumary statemnt of your own data.
Porhaps you would
writing a
of your msoamh
and pmmting son» of the data, specifically any of you more
mount studies which my not yet have been published.

wider

awry

Since we would like to print a program including abstracts
for distributim at the meeting, would you favor m by a single
paragraph or two describing your presentation?
I led: forward to your presentation.

Slowly
Max

Fink,

your-s .

PM).

Professor of Psychiatry

�</text>
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                    <text>_

m.

V. E.

tango
Laboratory of lhmpentieal
Istittxto Superiom di Smite:
Pane,

Hammer 12. 1935

Mm

Italy

‘

Dear Dr. bongo:
The C.I.N.P. Brow Camittee for the; forthcoming meeting
in Hashingtm on March 28~31, 1966 has asked Dr. Philip 31’le
md myself to arrange a aymposim an the general tepic of neurophmcolow. We have decided to mange a swim outta

subject of:

W3
-

a

WWWIC

.

Anticholinemic hallucimgens have' received considerable study
and the data relates to the pmblm of central nervous system
dzalinergie mechanism in the
bffects of various
and to the special problmn of the anaemia.-

micof mama,
and behavior.
trim

Watic

EEG

kmmizing your expérim ﬂiﬁ‘l these ammds and yam
interest in these problem we mum like to invite you to
participate in this
1. If you am able to accept this invitation, would you
please send an a gamma titlc for your pmmtation, and a
manpammphdescvibing the focms andtypeofdatayouwish
to pmsem?
Upon moaipt of these achmledgmnm , Dr. Bradley and I will
make up a rammed pmgmn balancing the time for magentatime and discussions. The C.I.N.P.
has agreed that
this symposium will have at least onemane
session of simultmeous
translation, 8a thtt reports may be present-ad in tha lmguaga
of your choice.
_

wim.

'

.

2. me C.I.N.P. has not stated a general publicatim policy
and we propose to publish these reports md discussims as 5
separate volume.
~

,

.

anticipates that each participant will pay
in attending this mating. For those attending
from Europe, a charter flight my be organized by Dr. Philip Bradley.
3.

his cm

Tha C.I.H.P.

was

�I

Dr. Imago

~2-

Member 12,

1985

In the event that travel ftmda are necessary, please indicate
the
requested to supplement your available funds and
we will transmit these requests to the Program and Executive
Comittees for their decisim.

mt

u.

The

are being

emu” has asked that we indicate maximums

made by:

.

Hargmt K. Taylor
c/a C.I.N.P. Secretariat
3636—18131 Street, NW.

Miss
'

Washington, D.C. 29010

If

you

am planning t6 attend this meeting,

to bar directly?

Dr. Bradley and
sympoeim.

I

look
'

would you

forum to having you join

us in

Sincerely yours ,
Max

Fink,

PM}.

meessor of Psychiatry

MF:kp

write

this

�</text>
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                    <text>Juno 2!: , 1966

Dr. V. 8.

ItalyWm

Institum

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Sanita

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,

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submit abstracts of the wardens papers premtod
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Ihawe takanmeIiNrwofathmcﬁngﬂmamyof
yum report and am enclasing a mpg fox~ your consideration.

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mimifywuishmmctitmdmittommﬂy.
May

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Pink, H.D.
of Psychiatry

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Aprii 29. 1969
Dr. V. G. Longo

Istituto Superioro di Sanita
Viala Regina Elena. 299

w-

Rm. Italy

‘W.,...AW,.-vaww’w-mw

Wm-"

Dear Dr. Longo:
Thank you for your invitation to participate in the
Program Committee of the CINP in Rome. I vii] be arriving
on Monday evaning May 5 and will cail you when I arrive.

Sinceraiy yours.
‘

H

Fink. H.D.
Professor of Psychiatry

Max

3

:

wm'w.rv

—&lt;—~

v-

wy-v-w-

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7. ..

.77...

,

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“ms

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«vy

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... (3' ___,7,.,‘ m... “av-.mvn—pvmm
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v. mw..~..r-w..—mu--w\

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1

i

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t

E

June 2, 1969

E

l

i

I

E

S

E

E

Dr. v. G. Longo

Institute Superiore do Sanita
Viale Regina Elena 299
Rom,

Italy

Deer Enzo,

It was

a pleasure to mxk with you in Rome and Liege.
received the promsed summary of the proceedings

You have by now

E

E

E

i

l

_»

g

g

in Liege.

In our discussions with Alex, and in Liege, I was impressed
with the progress in the understmding of cmtnal neurolmnors ,
including the "Initiative" ores. For some tire I have been
particularly interested in the CNS effects of re .eted grand-—
mal convulsions (as in electroshock ﬂumpy [ECT ) when I
reviewed the available biodxemistry in 1959—60 and again in
1965 , I enpimsized dwlinergic molmisms because the data was
available; and because of my special ecperiences with anticholimrgic
drugs.

Isupposeoneomldnekeasgoodaceseforcentml
ECI’ as for dwlinergic. Perimps
the time is right for some ackiitional study, and I am taking
the liberty of sending some of w reprints in the hope that
their critique may become the basis
for dismesim.
I would be particularly pleased to have you visit New York
Bywaﬂxaninetic d'zanges in

m.

~«Mwwm‘.

.

this fall; and want to take this opportunity to them:

your hospitality.

“an

‘

‘

My

best regards .
Sincerely yours ,

rm Fink, 14.0.
Professor of Psychiatry

you

for

in».

.mwnww-‘

.

.

�</text>
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                    <text>July 28,
~

av
.,

paw."

:v.

11". V. G.

1969

ngo

Institute Superim di Sanita
Ram, Italy

mﬁ-r‘w-V‘

'

,

rs

wrm

yuaa'

Dear Duo,

will be pleased to have you pmaent your work to some
ofmyassociatesmﬁueZmd. Ilod&lt;forwardtoseeingywin
We

California

and

then in

New

York.

Sincerely yours ,
Fink, PM).
Professor of Psychiatry

Max

MFﬂcp

�</text>
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Fink, NJ).

Professor of Psychiatry
MPdcp

v'rlrv

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‘

Wen'nﬁv’n

was.

r.
-v

August 15, 1978

Docteur Henri Loo
Paris , France
Dear Docteur Loo,

for your inquiry about the report on the
which was presented at the CINP meeting in
Vienna last month. The paper has not yet been prepared or accepted
for publication, and cannot be cited in a review.
mechanism

Thank you

of action of

ECT

However, there are a number of my more recent papers
which you hay not yet have seen, covering the same material. These

include:

Efficacy and Safety of Induced Seizures
Psychiat. l2; 1—18, 1978.

Is

in

(EST)

Man.

ngprehens.

a

Useful Therapy of Schizophrenia ? In: J.P. Brady and H.K.H.
Brodie (Eds.): Controversy in Psychiatry, Philadelphia, v.3.
Sunders Co., 183-193, 1978.
EST

Myths of ﬁahock Therapy". Amer.
EST: A

spldial
Io

Case

235-29“. 1977.

J. Psychiat.

in Pharmacotherapy. In:

ggg; 991-996, 1977.
W.

E. Faun

et al. (Eds.):

inlrnngggnnyof Depression, N.Y., Spectrum Publn.,

:1;.

mu

Wu;

«runaway-“3,“.-

In addition, I have written an extensive review of

"A

Sincerely yours,
away

law-w

17'

‘Wilm:rvml

tamwm

ECT

will be published in January by Raven Press of New York, entitled
"Convulsive Therapy: Theory and Practice". You may wish to refer to this
volume when it is available in a few months.

which

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 13, 1984

Prof. Henri Loo
Faculte de Medecine de Paris-Cochin
100-102, Rue de la Sante
75674 Paris Cedex 14
France
Dear Prof. Loo,
Thank you for your kind remarks in your letter of July 3. I enclose a draft
of my report to the CINP -- but you should be aware that this is a reading copy and
lacks the tables, figures, and references which a properly completed paper would
include. You may use it for your outline, but I must ask that you not quote it

directly.

I suggest that you obtain a copy of my 1979 book, CONVULSIVE
THERAPY: THEORY and PRACTICE, published by Raven Press. There has been
much progress since then, and I enclose additional reports which supplement my
book.

You may be pleased to know that I will edit a new journal, CONVULSIVE
THERAPY, to be published by Raven Press, which will appear early in 1985. Should
you or your associates have reports which may be suitable for such a journal, I
would be pleased to receive them.
My regards and best wishes for the success of your

efforts.

Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>m... V"...we:

November

2, 1979

Peter T. Loosen, M.D.
Dorothea Dix Hospital
Raleigh, NC 27611
Dear

Peter.

Thank you for the two articles, on the oral treatment
of depressed patients with 80 mg TRH and the review of peptide effects.
I had seen the Karlberg et al article, but in light of our discussion,
I should be disappointed and assume that the likelihood that TRH over
three weeks would be significantly antidepressant. Yet, the many observations
including the three patients who responded in this series, suggests that
we may be close, as close as the early workers were with l-dopa in parkin-

son patients.

For the meanwhile, I have decided not to replicate the study;
but rather to try with two of the newer peptides, DGAVP and des-Tyr-gammaendorphin, to assess their central (EEG) effects.
My associate, Yiannis Papakostas has been carrying out
stimulation tests and dexamethadone—cortisol tests in every one
of our depressed patients, referred for drug therapy or BCT. So far, in
the first 15 patients, he has found more consistent DM-cortisol abnormalities which resolve with treatment, than TRH-TSH but the latter do occur
in about 1/3 the cases, and he is confirming the observations of TSH blunted
response in some depressed. He is using our schizophrenic patients as
controls, and we are particularly interested in the ECT group.

TRH-TSH

It

was kind

of

you

to think of

me, and my

thanks.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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                    <text>Jmuary

1h , 1966

«

,.

r

,
..—

.v

‘.A...v&lt;.,._

u_

.
v

(w...

,
q...

.
u,

“aw."

.

:
.17

qunmm

WW,

u-

-;
w

-.

mwllzmv-w'

”’Eu'

m“,

_,

—..

mwr

.7,

g&lt;.;,g;.r...m.—

“.1”

;-—~rvnwl

2'.

.mu.

Mr. Rabat-t A.

lam:

Wratiw

Salas
Tram world Airlines, Inc.
1&amp;2:

[out Strut

3t. Innis,

2&amp;8st 63103

Dam Kr. Lama:

merymﬂnforpmvidingmwiﬁatho

It is indeedahandoome
mmaxImmted.
Madurofﬂusewimuhidzmrxmbomsokind

to pmidn auxin; the past to: years.

Sincerely yours,
Pink, ”.11.
Executive Director

Mm:

MF:kp

�</text>
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                    <text>March 19. 1953

Heuriee Lorr, Ph. D.

Chief, Outpatient Psychiatric Research Lab.
Veterans Administration Benefits Office
Washington, D. C.
Dear Dr. Lorr:

I wenld appreciate receiving a copy of PBlO-SOY,
the bulletin which describes the HSRPP as it was originally
develoPed.

I enjoyed your participation in the meetings in
washington last week. Many thanks.
Sincerely yours,
Fink,
Director

Mex

MF:ew

M.

D.

�</text>
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                    <text>August a, 1963

Loss

Gates Dodge

San Jose

Califomm

Gmthmm

I

to attain! the
9‘11, 1983.
Septenber
Jose.
am plarming

IBM

Workshop

in

San

I mix: like to make a memtion for the nigats

of Summer 8. 9, 10. a 11 and hold for late

arrival.

Please confirm

this mmwatim as seen as possible.
Sincerely ,

Mf'uk

Fink, ”0
m
Mmctw

Do.

�</text>
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                    <text>T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our BEG profile
analysis studies, as the basis for any recommendations you may wish
to make in Westchester to IBM or other organizations.
I

am

techniques are applicable to the Ocean Systems interest
in "neurophysiological responses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

Mszt

�</text>
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W

T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our EEG profile
analysis studies, as the basis for any recommendations you may wish
to make in NestcheSter to IBM or other organizations.
I am

techniques are applicable to the Ocean Systems interest
in ”neurOphysiological re5ponses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

MF:kt

�</text>
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                    <text>August 14, 1964

Dr. Lowoll Bolliu
Director of Public Health

Springfield,

Moosaehuoottu

Dear Dr. Bollin:

Dr. Gerald M. Abraham. now of Tel Hood, Israel, and formerly
house physician at the Chronic Diseases Hospital in Spring~
field. has opplied to the Institute for residency training in
psychiatry. ptepsratory to a corner in the treatment of the
severe mentally ill. He has auggestod we inquire of you ro~

gatdins his qualifications.

would be grateful if you would share with as your recollections
regarding Dz. Abraham's ability on a physician, his intellectual
ability and capacity to undertake a now corner, and his personal-

we

ity as related to his patients and ¢o~worketa.
I have just met Dr. Abraham and found him pleasant, friendly and
ainoero. Rio wife appears dovotod. Bis reasons for turning to
psychiatry are unclear. and yon: recommendations will be of help
in judging his applicotion.

Thank you

for your cooperation.
Sincerely yours,
Fink,
Diroctor
Max

MP/jb

M.

D.

�</text>
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                  <elementText elementTextId="104627">
                    <text>April 19.

DP.

225
New

1953

WI,
Strut
fr. Wt:
Itwas aplemumtodiamayumsmdypmgmduﬁngny

WI."

H. D.

East 70th

York, ﬂew York 10021

Dear

moat visit to the New York Medical College. Your proposed
convex-ism of imiprimine and
as mutiv—dapmsamta
is an interesting study. especially
is misc! out in an
mmpatiem“ populatim.

chlorzmm
if it

mmmmmedalmsoaleoonnbomivosmdym
In eight hospitals meantiva patients

based on this report.

Wis

@13th to the institution with the
of depressive
disorder will be manly assigned to ﬂame mamnt
mocks ,
dulorprmazine, Mminim or plaoebo. The groups are now wader-

tﬂdﬁﬂwmolindmrystudiesmdetemedosagemgea
em
ontimmteesoﬂutﬁmivdnﬁniﬁwmoanbecaniod
out with the best
and

results.

I was also-interested in your
Dr. Freeman two articles on LSD momma-st

and have wt to
1.8meij
of drug addicts.

I

donotkmwifﬂmsewillintemtym,solhmsmtthemm
tohimintlaewntﬂutﬂmiamwﬂmmuberofﬂnstaff
who may find them of mm direct intemt.
'

Good 1nd,:

in‘your audios.
Sinoemly yous,
Max

Fink,

H. D.

Professor of Psychiatry

�</text>
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                    <text>”rum-‘—

Tam-655

April 30. 1973

gyv—gmzmr

.

.

1,

-

‘5‘mn’a7'w7—vy-Juew4’:

,

Ms. Linda

Stein.

Membership secretary.
250 West 57 Straw. Room 1201,
1!“ York, NJ. 10019‘

It is difficult for we to decide on whether my
activities in the rmmmm your: V111 be in Suffolk

a

county, where I haw
office. a: in Hanan County,
I have my ham. I m not enthusiastic about
making that choice at 131“ mount um, and ﬁhoreforo

where

this ”quest for tmafer of membership
snub a use an I «a
Until
magma.
that
decision, I with to resign from the Rev York County
District Branch, without specifyim Mattie Branch
an returning

m

Membership.

Binenraly your: ,

Fm. “CD.
m
Professor of

thu‘bry

lit/13

Em .

�</text>
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                  <elementText elementTextId="102690">
                    <text>Septembor 6, 1968

Dr. James Lowry

Director, Dopsrtusnt of Mental
1500 Fifth street
Sscrsnsnto, California 95816

Hygiene

Dear Dr. Lovry,

repott presented at the Hostsrn Institute was
st our study units and presented
in various papers. ooms published sod some in press. The
most recsnt sunosry is that prepared for Dr. Phillipson's
The

a synthesis of dsts collectad
volums on drug dependence.

entitled "Antagonists in the

Treatment of Opiate Dspsndsnce“.

Additional reports are enclosed as background material.
Thank you

rsvidw of the

for your interest

LSD

and for tho excellent
and hallucinogenic problsns in California.

Sincerely yours,

v
«A

,

Pink, M.D.
Professor at Psychiatry

Max

v.
.4

”—2,;-

.v'v’

V'Wv‘ltw‘”.-qw:m"ﬁlw;nvrrvyz'JVa*-'

w

v,»

ml

�</text>
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                    <text>v.-.~

r.-.

.—

-.W......_-_

r-&lt;~

A

Vanna—w

’4)

April 27,

1972

Dear Turan,

KBknel's observations of a definte relationship between
marijuana use and hard drug use should be reported, if the data is indeed
good. To my knowledge, there is no satisfactory of any causal relation
between the use of these drugs; they are often combined by propinquity.
The issue of causal relationship has been reviewed by the Commission
on Marijuana in its recent report (1972) and by the two reports
of the Surgeon General to the Congress on marijuana use—— 1971 and 1972.
ypuucan imagine, defining a causal relationship is
and I doubt that KBknel's data is much better than that
,presented before. Should you be convinced of its merit,
is eminently
publishable. Perhaps, you would write to Leo Hollister who is
organizing a marijuana session at the CINP and he may give KBknil
most

As

difficult,

it

some time.

Don came

back from his

visit all

enthused with the fine

data you are getting in Copenhagen and in St. Louis.

work

!

My

best regards to Ellen.
Max

Keep up

the good

�</text>
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                    <text>February l7,ol96k
Dr. Ardie Labia
Dept. of Clio. &amp; ﬁoclol Psychology
Walter Reed Army Institute of Rooooreh
Waltor Rood Army Hedldol Center
Waahington, D. G.
.

Don: Axdlol
Some months ago, no not in John Stoxn's room in Washington
whoa we were all attending a mooring. At that time, I had

that you were planning on oomlnz to St. Louis
but since then the rumors in the city are the: you will bo
joining Dr. Anthony this fall. 'Congratulatiooo!

no knowlodgo

I have found tho move to St. Louis was: stimulating, and tho
resourch opportunities horn are oxcollenc. I-troo: that
your laboratory will grow rapidly.» My-ansociatos and I
would ho pleased to have you

trips to St. Louis.

Again,

my

visit with

no on one

of your

best wishes for success of your program.
Sincerely yours.
Fink,
Dlrootor

Max

PIP/1h

14.!) o

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                    <text>.F,

..W—.—.Ar

m,‘

..

.v-.

_

N,

V

‘w._

“wav—JWD

February 17, 1966
wwwwwww,

"—

Dr. Arﬂx‘ Labia
Dept. of Clln. &amp; Social Psychology
Walter aged Army Inttttuta at Rauaarch
‘WQIter Rand Aruy Hadicnl Cantor
Washingcan, D. 0.

WWW

unwn—n-mme—w—

Dust Axdicl
Sana months ago, in In: in Jahn Stern's roan in Washington
when at vote all attending a amazing. At that tint, I had
no knowlndgn that you V!!! planning on mowing to St. Louis
has atacc than aha rumors in th: city are that you will be
joining Dr. Anthony this fall. Congratulations!

I have found tha nova to St. Louis Host stimulating, and the
rcluareh opportunitias hcra are cacallenc. I :tust than
your Inhoracory will grow rapidly. Hy annociatcs and I
would be plaalad ta hava you visit with us on one of you:
crtps to St. Lcuiu.
Again, aw bcot wishes for auccann a! your yragran.
Sine-taly years,
13“ Fink, 3.1) o

mwvwm-

”mmvawmm—WWWsW-ww—mw:m

-

Dirnetor

HP/jh

�</text>
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                    <text>July 16,

1968

Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego. California 92l52

Dear Ardie,

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

to read it. since I have just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory, exce t that there are
additional tables such as you request spage l6§ describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication. but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.

difficulties

which you describe - difficulties which are described
this approach. and also found by ourselves - are
the lack of discrimination of small differences in this method.

The

by others trying

Perhaps the lack of discrimination is related to the paucity of
samples for study ~ if I understand, you analyzed l8 selected
minutes of an all night sleep recording. This small sample is
related to the cost of power spectrum.

That PNRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REH and stgge 3 from stages 2 and 4 are the same
problems we faced in power spectrum. Additional discriminations
are possible in period analysis. for the stage I - stage I-REM
discrimination is now available; the stage 3 discrimination is
feasible following your suggestions (page l8) and some of our own.

�Dr. Lub1n

Ju1y 16, 1968

-2—

Some of the
I agree w1th your conc1us1ons (page 17).
recommended add1t1ona1 data 13 ava11ab1e or 15 read11y
programmab1e us1ng per1od ana1yt1c and the d1stance funct1on

‘

approaches.

Perhaps the t1me has come to compare the ava11ab1e methods
for systemat1ca11y co11ected data. As I 1nd1cated ear11er, we
are prepared to ana1yze tapes us1ng the per1od ana1yt1c methods.
We wou1d be spec1a11y 1nterested 1f they are a1so to be ana1yzed
by)our methods. The costs 1n do11ars and t1me are negot1ab1e
and shou1d compare favorab1y w1th the expense and delays wh1ch
you descr1bed for your present systems.
Such ana1yses cou1d be done as part of a demonstrat1on for
an APSS meet1ng and as the bas1s for a d1scuss1on of the ava11ab1e
methods. If th1s is not feas1b1e, we wou1d st111 be w1111ng to
cons1der a demonstrat1on for you at a cost that 15 comparab1e to

that of Astropower.

It was a p1easure to hear your report 1n Wash1ngton, and to
read th1s prepr1nt. Perhaps the enc1osed report W111 perm1t you
to be more opt1m1st1c about th1s rea1—t1me (or 2-4x rea1 t1me)
ana1yt1c system for the re11ab1e and automat1c scor1ng of EEG
sleep stages.
My

best regards.
S1ncere1y yours,
/ﬂax F1nk,

M. D.

Professor of Psych1atry

Mszp

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                    <text>July l0, l968
Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego, California 92l52

Dear Ardie.

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

it, since I have Just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory. except that there are
additional tables such as you request (page l6) describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication, but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity to read

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.
The difficulties which you describe - difficulties which are described
by others trying this approach, and also found by ourselves
are
the lack of discrimination of small differences in this method
except at a great expense in either time or dollars or both.
—

That PHRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REM and stage 3 from stages 2 and 4 are the same
problems and the same discriminators we face in period analysis.
Some additional discrimination: are possible in period analysis,
for the stage 1- stage I-REM discrimination seems now to be
working; the stage 3 discrimination is feasible following your
suggestions (page 18) and some of our own.

�Dr. Lubin

July l0, l968

-2—

conclusions (page l7). Some of the
data is available or is readily
programmable using period analytic and the distance function
I agree with your
recommended additional

approaches.

Perhaps the time has come to compare the available methods

for systematically collected data.

As I indicated earlier, we
to
are prepared
analyze tapes using the period analytic methods.
We would be specially interested if they
are also to be analyzed
by our methods. The costs in dollars and time are negotiable
and should compare favorably with the expense and delays which
you described for your present systems.

Such analyses could be done as part of a demonstration for
an APSS meeting and as the basis for a discussion of the available
methods. If this is not feasible, we would still be willing to
consider a demonstration for you at a cost that is comparable to
that of AstrOpower.

It

was a

My

best regards.

pleasure to hear your report in Washington, and to
Perhaps the enclosed report will permit ou
to be more optimistic about this real-time (or 2-4x real time
analytic system for the reliable and automatic scoring of EEG
sleep stages.
read this preprint.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>June 27 , 1987
Br. Arthur J. Lunny
Chart Paper Sales
Grass Instruments
Quincy, Massachusetts 02169
Dear Mr. Lonny:

for

will be receiving an order
following the teleprxme quotation
copy of the order is enclosed so that you

h the regular channels you

100 packs

of

EEG 30~8"-WROR

of $3.25 per pack.
can anticipate it.

A

Because of storwe problems , I would be grateful if you
would ship us 25 packs and holding the reminder until notified
by this office. Would you bill us for the total amount imnediately,
since that would be easier than billing at other times.

I have rarily used imprinted paper, but perhaps for this
new Department, it would be helpful using as small a type as is
reasonable. I would like to have the paper imprinted on a single
line as follows:
EEG

and iiuman Psychopharmoology

~

Department of Psychiatry
me

appreciate your settling the
as soon as practicable.

first

I

would

NY

.

shipment of 25 packs

Sincerely yours ,

Wm.

M"

.,,,

VIM-w...

Fink, M.D.
Professor of Psychiatry

...V

Max

..

,

wm-4mﬁyvef-(¢.w.qwf

MF:kp

Medical College

before hand, I would be

sanple of the type could be sent to
pleased. If not, go ahead.

If a

~—

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                    <text>my-w' wwwvwwisz—m

July
Mr. Arthtm

J.

12 , 1967

Lunny

Chart Paper Sales

Gmss Imtnment
Quincy, Massachusetts 02169

Deaer.

bunny:

We

The
order No. loullu has been signed and should
arrive within the next few days. Ehcloaed is the contract

requested.

If you cannot ship 25 packs of the imprinted
before
production is shut doom, please send me mﬁmprintedpaper
for
paper
the first order.
Please send me a statement for the full annunt due for
plus the additional service charge, assuming them
will be shipmmtsof 25 packs at a tim for the reminder
of
100 packs

the contract.

Shmrely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January 8, l968

Arthur J. Lunny
Chart Paper Sales
Grass Instrument Company

Mr.

Quincy, Massachusetts 02169
Dear Mr. Lunny:
boxes

On

our outstanding oeder of

to

my new

laboratory.

EEG

paper. please ship

25

Dr. Max Fink

Department of Psychiatry

Metropolitan Hospital,

First

ﬂew

Separately

December 29,

we

Avenue

at

Room l5A9

97th St.

York, New York 10028

are sending you an additional order, dated
100 boxes. Please bill us promptly.

for another

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>-~-vVI'”FA.-7'I(4—

,,. ..~—..\....g..

,

r'wvuw- "W“;

gm.

.—..—~..r; ,‘mw—

z-Wm—q-q—‘vw-“aw—Amean». gawk-m.» .m .~-.—’V"r

..

_

:,

...

in,”

N 73 oafﬂ/

73N-od8m

‘

January 5. 1973
Mr.

Arthur J.

Lunny

Grace Instrument Co.

Quincy, Massachusetts 02169
Dear Mr. Lunny,
Thank you for clarifying the remaining order for EEG chart
which
I have with Grace Instrument Co. In the ensuing weeks,
paper
my staff will call and ask that the remaining boxes be shipped to
one of my two laboratories, at the New York Medical College, or

Building Surge

I,

Room

2310, Health Sheencee Center,

Brook, Stony Brook. ﬂew York 11790.

that are
result of our split shipping.
charges end service charges

H

g
5

,

We

SUHY

at

Stony

will defray all shipping

due or may become due no a

With regard to purchase order

516318 dated 11/29/72,

I have asked the purchasing department to cancel the item #2,
"50 packs EEG paper. 10", at 3.75, $187.50"; but to retain the
other 3 items, for electrode cream, pens, and IF 100. If not yet
shipped, I vould appreciate your sending these items to my attention
at:
Department of Psychiatry

5 East 102 Street
New York City 10029

I em most grateful for your cooperation, end wish
your associates the beat of health and success in 1973 l

you and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>November 20 ,

1961+

Dr. and Mrs. Jacob Lustig
36 Jaffa Road

Jerusalem, Israel

Dear Dr. and Mrs. Lustig:

visited

you

It

has been

many months

in Jerusalem and yet

events of yesterday.

have talked of

little

It was

it

since

my

seems as

family and I

clear as the

a wonderful visit, and
else than our trip.

we

am enclosing a copy of the book that inPlease
accept this as a mneﬁto of our visit.
terested you.

I

When

I returned to

New York, my mother and
had the opporttmity to visit

V

father were excited that I'd
I hope that in the coming year they will plan a
trip to Israel and have the opportunity to renew their friend-

with you.
ship .

regards.

Martha and Jonathan join in sending our warnest

Sincerely yours,
Max

mfgls
e nclosure

Fink,

Director

M.D.

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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                    <text>May

21, 196:;

Mr. Waynn Lewis Lym
12 Kresge Street

Wilkes-Barre, Pamsylvania
Dear Mr. Lym:

Wemuldhopleasedtoappointymasﬁedioal
Labomtmy Technician II, to tho staff of the Misscmri
Institute of Psymiatty, affective an or abmt
195% at the rate of $388.00 per month.

Jm 1,

,

Hissﬂmxyhashighlymmndedym,and1
am

locking forwaN‘ to your joining the

staff.

Sincerely yours,
Fink.
Bumrtive
Max

H. D.

mmtor

�</text>
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                    <text>March 19, 1977
Mr. Robert Lyons
York Academy
2 Est 63 Street

New

New

of Sciences

York City

Dear Mr. Lyons,

I have received a large number of reprint requests
inquiries regarding the purchase of the volume 282 on
Chronic ﬂannabis Use. I am writing to ask whether the Academy has
printed descriptions and purchase order blanks for this volume. If
yes, I would appreciate about no copies. These will be sent to the
requesters with the reprints that are available.
and

Parenthetically, I recall that our agreement

the editors would receive
3 copies.

5

was

that

copies of the volume. I have received

I hope the volume is well received. From the reprint requests
already in hand, I would say that the interest is quite high.
Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

�</text>
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                    <text>Oetdher.25th, 1912
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                    <text>January 21,

19614

W3
Hr. Lodxgilptnad
Mum,
muslin
Scotland
m6'.

D. Lo

Daar Dr. Hadcenzie:
Dr.

J.

of Lanaashim has indicated an interest
march psychiatrist at the Mimouri Institute

C. Holden

in an appointmnt

a

warm as its
Wandmihing
mentally ill. and Mines both

of Psydﬂatry. This clirﬁoal
principal few; studies in the
clinical and laboratory . w
elecuwoenoaplmlogmmm

an

new

operational.

I

3am
Laboratories

clinical

paydmology and

«was
mummm

in r

'

-

would be grateful for your opinim mgazding the reward":
Ir. Holden. as wall as your estimate of his ability to

abilities of

mm.

participate in collaborative
Many thumb for your cooperatim.

‘

Sincerely
Max

Firm,

mmctcr
Mfsmlg

yam ,
M.

D.

�</text>
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                    <text>,
ll?“
May 15, 1992
Ellen P. MacKenzie, MD.
2216 Belle Chasse Highway

Gretna,

LA

70053

Dear Dr. MacKenzie,
very much appreciate your letter of May 5. am heartened, rather
than discouraged, by your plea to use my influence and reputation to enhance
the education of your colleagues. You represent one of those who came to a
course, and are now using your skills to treat patients who need ECT. That is
gratifying enough.
I

I

gave a lecture on ECT at the Ochsner Clinic. They sent a
to my laboratory for a week. And while have not
Heinz,
trainee,
Jerry
young
heard directly from him that he has begun to treat patients, another resident
introduced herself at a recent course and said that they had begun an ECT unit.
Last year,

I

I

The best can do is visit again, if the professionals at Charity Hospital
seek some help, either in teaching or in organizing an ECT service. But the
need must be felt by the professionals at the facility.
I

I

believe we are making progress.

The case reports published by Sandoz are not meant to educate, but
to indoctrinate. So long as medical schools and psychiatric organizations
depend on the largesse of industry, they will be subject to this type of
’education’. Gilbert Honigfeld is poorly acquainted with ECT, and has no interest
in any comparison bevvteen clozapine and ECT. When clozapine was still
’experimental’, proposed to Honigfeld, Kane, and Meltzer a study of their
treatment failures, i.e., the 70% of clozapine treated patients who did not
improve, with ECT at no extra expense to the patients. But we never received
referrals and only recently have Meltzer and Kane begun trials of ECT with
clozapine or after clozapine.
I

Good luck

in

your efforts, and many thanks fgor your kind remarks.
Sincerely yours,
Max Fink, MD.
Editor

�</text>
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                    <text>W

new 31, 1953
Mr. K.

Wtchie

Registrar
The Boss Clinic
Oomhill Road

Aberdeen

Scotland
Dear

m Wtchie:

'mmk ya: vary such for your inqmdxy. The Hissami Institute
of Psychiatry is the MGM am! twining comer of the Division of
1982, with
Disemes of
It was established inAtOctober,
the
time,
laboratory md clinical facilities for mam-ch.
WM:
£033
70
Luminaries
150
of
march
beds, we are utilizing

mm.

mm

mm.

WWW,

Why,
Gunter for bath statistical and
analysts.
War
Mmisaapccialimdpsydﬁatdomlibmxyasamtpm
am established in
as well as a
of the Imtitute.

paydnlow, and

Animal

In additim, them

facilitias an

now

being

BBQ

built.

is a fully qualified three-year psychiatric

at the Institute, and a spacial twining prothus research
mm in clinical Manley is being «magma. Both in
programs and in the mining prom, tbs Institute is affiliated with
the Department at Fwd-11am of washingtm mimity Samol of Madicina.
Atﬂxepmenttime,
progress. These include Lithim w a trump); for amid; the use of
Yohimine as a pmdpitmt of midst)! and the devalmnt of antianxiety amnts; mlatim of ms patterns mad organic factors in the
residency training program

unmamrofmmmmin
mar

analysis of the
treatment of trampy resistant psydxotics;
wimdzuaal
m beluviar in the
cleatxmptmlom; the effects of «mg

Manny ill; and the tmmt of psycmtics by

therapy.

m mlatmmhip

�K.

Mackitmic
31, 1963

War
Tm'

Page

Wm:
tannimtuofthaImtitute.

MW
m.
may

mtal or for min within
Itismrmtmtoprwidetowmtha Institution few scientists appointed

am availabu for

at

m

with exAppoinmnta am made at salary lamb w
ta
with
perience
a minim salary being $12,000.00 per- mmm. In
addition ta march
aatisfactozy mimic: of. the {PM
is mimd heavily in the dutcminatim of salary. Satisfactory camplatim of the acme enmination with either a twenty or
artifimte is prerequisite to appoinw't.
a».

swam,

mt

I am enclosing a 1962 description: of the Institute. If this
oppoztunity interests you, I would appmdata a eopy of your unwieulum vita listing
your admtiaml and Nominal
In
exporianaa.
addition, a snail phatmph and tin was of at
least

two

mmwy

mfm tom‘s. maywrito would be met helpful.
Sincerely
Mm:

Fink.

Director

Mfmlg

Ema. 1

mm.
H. D.

�</text>
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                    <text>9W
State University of New York at Stony Brook
School of Medicine — Department of Psychiatry
Max Fink, M.D.
Professor of Psychiatry
PO. Box 457
St. James, New York 11780

Phone: 516 4442929
516 862-6651

September 21’ 1993

Fax: 516 862-8604

Mr. Marty Madison
Quest Publishing Co.
Brea CA 92621

Dear Mr. Madison,
Thank you for sending me the DHEW announcement in the Federal
Register regarding the FDA classiﬁcation of Cranial Electrotherapy Stimulators. Yes,
these devices are the same as we assessed in the early 19605. It was the reports of RB.
Smith in the 19805 that led the US. Army physicians to examine the advisability of reimbursing CHAMPUS personnel for such treatments that led to my review.
My library contains two volumes which cite such research.
Reynolds DV, Sjoberg AE (Eds): Neuroelectric Research: Electroprosthesis,
Electroanesthesia and Nonconvulsive Electrotherapy. C.C Thomas, Springﬁeld, 1971,
466 pp.
Wulfsohn NL, Sances A. (Eds): The Nervous System and Electric Currents, Plenum
Press, New York, 1971, 171 pp.
Another set of data can be found in the literature of convulsive therapy
under the term 'subconvulsive shock' or 'nonconvulsiveelectric stimulation' or
'electrosleep'. A good source for such experience is to be found in two old texts:
Alexander L: Treatment ofMental Disorder. W.B. Saunders, Philadelphia, 1953, 507 pp.
Kalinowsky L, Hoch P: Somatic Treatments in Psychiatry, Grune &amp; Stratton, New York,
1961 [or earlier editions].
I would like to read your report when it is published. Thank you for
keeping me informed.

M

Sincerely yo
Post-lt‘" brand fax transmittal memo 7671 l#of pages &gt;
To
From
xy

“/ka

Map/lam
‘1

Dept

Fax"7/4

525

5257—

C,

Max

/

kw"

PM“ #974 +144
PM 574— 4514

‘

/

29%
7534

3,

Max Fink , M.D
Professor of Psychiatry
and Neurology
.

�</text>
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                    <text>October 14, 1968
Mr. John Haher
Bureau of Narcotics and Bangerous Drugs
633 Indiana, N.W. ~Room 510
Washington, 0.0. 20226

Dear Mr. Maher:
Thank you very much

receive a

letter

for your c00peration.

You

should

from ﬁr. Harold Slumberg of Endo Laboratories.

Enclosed is a capy of the report submitted to us by
Dr. Schwarzkoof regarding the analysis of the heroin recentiy

sent to us.
Again

my

thanks for your cooperation.

Sincerely yours.
Fink, “.0.
Proféssor of’Psychiatry

Max

MF:kp

�</text>
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                    <text>November

l8. l968

Hr. A. Mahmood
Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmoud:

Enclosed are two capies of our report "Psychoactive

Drugs and the Alert EEG"
Medical Review.

to

for publication in the Pakistan

its

publication and would appreciate
receiving a capy of the Review as well as the reprints you
‘suggested.
I look forward

Sincerely yours.
Fink. ".0.
Professor of Psychiatry

Max

Mszp

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                    <text>Septembea 1, 1968
Ma. A. Mahmood

Phhiotan Medical Reuimm
Kamchi, Pakistan

Dena Mn. Mahmood,'
Thank you 60&amp; you&amp; bind

in the special edition

the Pahiaxan Medicot Reuiwm.
I do not know goua fouanaz, ozonextabzy, and.ao 51nd
digﬁicutt
to know if the monk we have been angaged in wouzd Lntenaot youn
neadena. Pemhapo a ££At of tho conﬁnibuxnno to the volume

it

In the event that
doeo Lntnneot you, I «outd be
oend
paepaked to
you an «dilate entizzzd, "Paychoactive Dnugé and
the Aleat EEG”. It £5 apnaoximazezy 20 paged in £engzh, doubﬂa
apaczd; uuik.50 neéeaenczb; and adom 3—5 tabled and 5~8 giguaeo.
Such an atticta could be paepaaad by the and 05 ﬂczobam.

I

own-,1

vr

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wouzd

appneciatn knowing the

numbed 05 conLeA 05

the Reuéuo,.nep&amp;£n£5 and honoaaazum which authoao may aecetoe
in pamtécépation In thio vozume; in add£t£on to the Eiot 05

inuﬁtad conznlhuzoaa.

Thank you again 504 gout

thd £nvi£at£on.
ﬂincemezy gonad,

Fink, H.D.
Pwoﬁeoooa 05 Paychzatng

zhxx

Pineatoa, Divialon

m“!

-Hn'

it

mould be 05 help.

1:-

.:-‘='AV,'aI'-‘.r'~

invitation to pantietpate

on poochiatng 05

MF/

06

PAgchoohaamacozogg

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                    <text>r-«ar-x—rwm

an.

“an“:

uhmwzwmm-vvw’ﬂ'ﬁuﬁtwﬂ'r a -w-Iva~.‘:".w

.4

-wn;.~‘\&lt;’-'

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we. “mu-w

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A
A

warn—v."

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r

Wk-w

"WW—«mwmvm—w

November 18. 1968

Br.

A. Mahmood

Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmood:

Enclosed are two copies of our report "Psychoactive

Drugs and the

Alert

EEG“

Medical Random.

I look forward

receiving a copy of
suggested.

to

for publication in the Pakistan

its

publication and would appreciate
Review
the
as well as the reprints you
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

‘7'?er

«ar “—3-:

..-.-~»

“Mm-{w-‘n'nwt

.

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1. 1969

Dr. Ra Pa “nickel
Aaaoctaca Proton-or of Pharaacology
Laboratory of Payehopharuacology

Indiana Untvaraity
Paychology Building
Bloc-ington. Indiana 67401
Dear Dr. Haickalx

Thank you vary such for your invitation to aarva on the
Board of Con-ulting lditora for tha Jouanal 06 Behaulonal
9y. If I can ha of any halp in launching your

purpoaad nan journal,

1

will ba plaaaad.

Goad 193k.

Sincaraly youra,

“I! Pink,

Hana

Profaaaor of Psychiatry

Hrtkp

�</text>
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                    <text>May

1, 1969

Dr. R. P. Mbickel

Associate Professor of Pharmacology
Laboratory of Psychopharuacology
Indiana University
Psychology Building
Bloomington, Indiana #7401
Dear Dr. Maickel:
Thank you very ouch for your invitation to serve on the
Board of Consulting Editors for the Joulnal 06 Behavional
PhaAMacotogy. If I can be of any help in launching your

purpoaad new journal, I
Good

will be pleased.

luck.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFskp

�</text>
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:wn‘r‘ w—wuwr-Mu'ww"r'\ﬁ._'.~'v

~

"¢i\y~

Y

u.

.ww

u. ~.'nww«v—,- .mp1..-«,;w,,m-rsr.v~g.w,...,.,.Vin.

,,

November 5, 1969

Dr. Roger P. Maickel, Ph.D.
Professor of Pharmacology

Indiana University

Medical Sciences Program

Hall,

Myers

Room 360

Bloomington. Indiana 47401

Dear Dr. Molokai:
as a

for your invitation to articipnto
of
the new journal Mouton anmacology
editor
consulting

Thank you ﬁery much

and PAychophanmacaﬁogy.
The only

potentially suitabla manuscript

on my desk now

is enclosed. ”Electrographic Effects of Diacetylmorphino
(Heroin) and Naloxone in Man" was originally prepared for the
Bnizébh Jouhnat 05 Addictionb, but I would be pleased to have
appear in a new journal. The subject of heroin addiction
it
and its treatment with naloxone is an important research issue
today and we would like to have this material appear within
a reasonable time. May I ask that have your decision
within six weeks?

t

Again,

my

thanks for your kind

invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
CDC.

..

�</text>
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                    <text>«v.-

1:
oz:-

Wm

t5"

saw-wave

«w

vmmpa'u'wl

January 14, 1970
Dr. Roger P. ﬁnickel, Ph.B.

Professor of Phsrmacology
Indiana University

Meéical Sciences Program

Hall,

Myers

Room 360

Bloomington, Indiana 47401

Dear 9r. Maickel:

sent a copy cf ”Electrographic
Effects of Diacetylmorphine (Heroin) and Haloxone in Man"
for your consideration for the new journal ﬁgggppharmacq}ggx
0n November 5, 1969 we

and Psychopharmacolqu.

must be very difficult to liunch a new journal.
Nevertheless, we would like to ask whether this manuscript

It

is acceptable or whather
Thank you again

we

should submit

it

elsewhere.

for your invitation.
Sincarely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>MEHORAHDUE

march 15, 19 72

TO:

Mrs. Ebert

F3024:

Dr.

SUBJECT :

Painting

Max

--

mint-none.

Fink

'\

We

paintadhgi
appreciate having room 42A and
\
tow
days
beginning
be
for
a
free
laboratories will
Lab 62A

would

\15‘.

The

butch 28, to ﬁnch 31.
He

would

like it to be painted a lightlz tinted blue.

Charge 89-21043 .

‘t

\\ \
».\

�</text>
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                    <text>Haven MI

October 15, 1963

mm
mm
1300
m
Dr.

Circle
mm
Yak
19.
M

10

mm».

N: Y.

W:

I m looking toward to seeing
We «made

1963.

you on mundey, October 2%,
reservation
the
Clayton Inn for you for
at
a

the night of October

23nd.

I will be

home

thet evening and

ifywwilleellmmyouemive.wemu1dbachlimted

to have you visit with us.

Sincerely yours .
Max

Wtw

PM,

Dim

Me Do

M579

�</text>
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                    <text>.

wow-pv-

,

w—m

“we—“rm.“

“unwan-ntv

WWI-“1”,”.

—A'rI.-‘

February 6, 1979
Barry Maletzky, M.D.

Portland, Oregon 97202
Dear Dr. Maletzky,
Your letter of inquiry relating to our experience with
the MECTA and with MMECT was referred to me fbemreply. As you know,
I visited Paul Blachly in Oregon in 1968 and undertook a series of
confirming studies of MEOT. The publications relate our experience,

which was not good.

In 1976,

we

purchased a

MECTA

instrument. In our

initial

treatments, we were unable to achieve a grand mal seizure using maximum
current intensity and settings. We called the manufacturer, returned the
instrument as he requested, and it was returned to us, with the
assurance that a faulty part had been replaced. We again attempted
to induce seizures and could do so at the maximum settings. When we
attempted to use unilateral electrodes, we were unable to achieve the
higher currents needed for such inductions. Gradually, the therapists
replaced the instrument and when it was no longer useful, it was
shelved, where

it

remains today.

In the review of

which was undertaken by the

MECT

(among

other modifications of

ECT)

Task Force on Convulsive Therapy, we were
unable to find systematic data which would assure us that this modification
was safe or more effective than routine ECT, expecially with unilateral
APA

electrode placements. Our conclusions are cited in the Task Force report,
#lh of the APA reports, dated November, 1978.

In my own review of ECT, which is in press and which will
be available by the end of the month, I come to the same conclusion, that

ﬂlﬂl indications for MECT are unclear, and further study is necessary before
its role in treatment is defined." In that statement, I am being kinder
than my real feelings, which are that MECT the little Justification
except as a research

tool.

acquainted with your very interesting report on the
outcome in ECT, as published in the
issue of Comprehensive Psychiatry. I have cited the report in

I

am

relation of deizure duration to

latest

�MuetZky,

wv.

BoMo

Coco-ell... FGbrum 6,

1979 ocean-000.co- page 2

review, and find your conclusions most useful. The possibility of
a therapeutic window for ECT is an important concept, and is consistent
with the experiences reported from my laboratory by M. A. Green,
who found that the duration of seizures changed with treatment,and
that thresholds usually fuse. But we were unable to define a ’window',
my

but then

we

didn't

have the concept.

With regard to the MECTA, there is need for better
ECT, and perhaps the unidirectional brief stimulus
approach recommended by Lieberson in the 1950's and lately by Weaver
is the way to go. But there seem to be inherent faults in the MECTA that

instrumentation for

.

will be useful in the clinic.
Similarly, the efficacy and applicability of MMECT is so far from demonstrated,
that a text as to how it should be applied clinically may be premature.
need remedying before the instrument

window'

in

ECT.

I look forward to your next report
‘

on

the 'therapeutic

Sincerely yours,
Max

Fink,

M.D.

VWGW’

w

Citations:
R. Abrams.

What have we
McGaugh, J. and

MECT:

learned 2 in Fink, M., Katy, 8.,
Williams, T. (Eds.): Psyyhobiology of

Convulsive Therapy, Washington, V.H. Winston, 197h. T9-8h.

M.Fink.
-

Convulsive Therapy: Theory,and Practice.
306

pp..

1979.

New

York, Raven Press,

M. Clinical experience with multiple electroconvulsive
treatments. gggprehensive Psychiatry 1;: 115—121, 1972.

Abrams, R. and Fink,

�</text>
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                    <text>-‘

Mww

.r

.

June 14, 1983
Barry M. Maletzky, M.D.

8332 5.13. 13

Street

Portland, Oregon 97202

Dear Barry,
Thank you for your letter of May 27 regarding an ECT journal or

newsletter.

Following Paul Blachly’s death, I considered continuing the Bulletin, but
the burden seemed too great and the need small. In the past two years, however,
the need has become greater, and I have looked into the question.

believe that there is little future for a journal dedicated to ECT alone. i
have approached some publishers, and each indicated, correctly I believe, that a
journal dedicated to one treatment would have a limited audience. More important,
it would not attract the best papers. The better authors and best papers would be
sent to the general journals, since there they would get the widest circulation. I
also enquired about an ECT section in a major journal, and four editors turned me
down; again, I can agree with their logic. They accept articles about ECT, and if
we made a dedicated section, we might get to use fillers with a negative impact on
I

quality.

‘

newsletter is another matter. I have approached three publishers and I
have prepared a prospectus for two of them. i propose a newsletter along the lines
of the Biological Therapies Newsletter, dedicated to the technical and scientific
issues of convulsive therapy. If I am successful in getting the funding, the first
issue will be out before the end of the year.
A

My

regards.
Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

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                    <text>February 23 , 1967
Dr. Sidney Malitz

New

York

New

York,

State Psychiatric Institute
Street

722 West 168th
New

York

Dear Sid,

I have recently returned to New York and
like to re-establish my association with some of the
scientific societies in the City. I would like to reapply
for reinstatement as a member of the New York Society for
Clinical Psychiatry. When I met Arthur Zitrin yesterday,
he suggested that I write to you.

I

As you know,

would

Would you

be necessary.
My

kindly send

me

such application forms as may

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 6, 1969
11‘.
New

Sidney Malitz

York State Psychiatric
722 West 168th Street
New York, New York 10032

Institute

Sid,

for your invitetim. to participate
Caimittee of the APA. You knm I would ’be

Thank you very much

in the

Mutants I mast, tell you”, however, that

I have no
committees
mimosa , having usually served on the program

pleased to do so.

of varims societies.
My

best regards.
Sincerely
Mex

Fink,

yam,
M.D.

Professcr of Peydmietry

MF:kp

~05:

�</text>
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                    <text>-

”Fawn-V?

WWW

5:

:Tntannﬁw

Febmry s,

....

A

,-

.nmvsq—n

wwrun-a.

Dr. Sidney bialitz
Rm York State Psychiatric
722 West 18 8th

New
man-z

York,

New

Street

1959

Institute

York 10032

Dear Sid,

‘

Them you vary méh for your

imitation to particiyate

in the Amangments Omit-tee of the

APA.

You know

I wwld be

I met tell yen, however, that I have no
pleased to
experience , having usually served on the program camittew
do so.

of various societiea .
My

best mgards.

M

535.11%me

Mm:

mm

M’mp

9""

15me???

2'
&lt;_
,

{KWW-7Fﬁ'ﬂl‘r

'r‘r'vzm-

.

,w

I
n
n1
-.

”L‘WWngVMKW-ﬂﬂﬁﬂif‘pw

Fink, MD.

Professor of Psydﬁatry

wan-r,

'mmx‘my

yams ,

�</text>
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                    <text>February 6, 1970
Dr. Bidney

Halitz,

APA¢Diatriet Branch
250 west 57

New

M.D.

Street

York City

Dear 51d.

I thank you for your axptasaion a! confidence in
the appointment as Chairman of the Cammittaa of Biological
Tﬁnrapisa of the district branch. and would like to accept,
but an unclear as to the reponaibilitien of the asaignuent.
Is the committee appointed already. and who are the Numbers ?
0:, may I recanmend a committee from the membarchip for your
approval ?
Are there questions before the committee? Are share
ongoing projects that may be raviewad and centinuad, at is the

coumtttee beginning

anew ?

I will call you to éiscuss these questions before
replying ta your kind recommendation.
My

best regards.
Sincerely yours,

Blnfatnhr ufnroychiacry

�</text>
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                    <text>*

,

annwn—mm.w_ww

,

I'W

~WIR

March 30, 1970

Dr. Sidney Malitz
722 West 168th Street
New York, New York 10032
Dear Sid,
The request of Dr. Joseph Meiers for a volunteer task force
of psychiatrists to support opiate dependent subjects in the
community using methadone was reviewed by an ad hoc subcommittee
of the Committee on Biological Therapies of the New York Society
for Clinical Psychiatry.
We

are aware of the public need and demand for care, but we
direct action be taken by the Society at this time.

recommend no

To recommend a single treatment model in a condition as
complex as opiate dependence is not satisfactory. The apparent
need is for recommendations regarding the applicability of an
apprOpriate therapy for each case, i. e. , substitution therapy

(methadone, heroin), antagonist therapy (cyclazocine, naloxone),
withdrawal and rehabilitation, group therapy, etc. To document
such a recommendation is complex and may be undertaken by the
Society. However, the issue is of national, not local concern

alone, and an APA task force may be a more appropriate body to
provide the necessary resolution.

The subcommittee, aware of the motivation for Dr. Meier's
motion, suggests that the Society review pending Federal legislation
(particularly HR 13743 and Senate 3562) to lend support to those
aspects or bills that may serve the interests of Dr. Meier's motion.

Respectfully,
Fink, M.D.
Professor of Psychiatry

Max

MF

:kp

For Drs. A.

M.

Freedman,

M.

Nyswander and V. Dole (ad hoc

consultant).

�</text>
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                    <text>September 4, 1970
Dr. Sidney Melitz
York State
722 West 168th

New

New

Psychiatric Institute
Street

York, New York 10032

Dear Sid,

pleased to nominate Jan Volavka, M.D. for membership in3 the
Society of Biological Psychiatry. I have known Dr. Volavka for
and
years. He trained with Jiri Roubicek, Creutzfeldt in Munich
and
psychiatrist.
Scott in London. He is a fine electroencephalographer
I

am

Roubicek
My

is

a

logical seconder.

best regards.
Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

Mszt
0110.

�</text>
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E
p.

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'PByahiatry this month,
understand why you called some months ago. If, indded,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data Ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Me:

MP:kt

�</text>
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www.mwmmmwmw

_.

_

!

E

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'Psyohiatry this month,
understand why you called some months ago. If, indeed,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>October 14, 1971
Dr. Sidney Malitz
Chairman, Research Commission

NYS
New

Psychiatric Institute

APA

York City

Dear Sid,

It

was a pleasure to discuss our common interests, both
en route to Europe and in Amsterdam. Also, I want to thank you both
for your help in the silver shop in the Rokin—— my daughter was
delighted with the silver stage, and I am not sure she will release
the Turk on the flying carpet to my friend, Turan.
With regard to your kind invitation to join the task
APA
the
force of
on drug abuse, I am pleased that the APA is
desirous of broadening the base of its experience. Unfortunately,
my schedule during the cominh year is overburdened by trips both
in the U.S. and abroad, and I will be unable to serve. A1 and I
have discussed the opportunity, however, and would suggest that
you invite Dr. Richard Resnick, Assistant Professor in our
Department, to serve. Dr. Resnick has been responsible for the
clinical programs in cyclasocine since 1968, and has the most
experience among our staff members. He is well qualified to present
our experience.

at

recommendation is acceptable, he can be reached
address, or by phone at 212 MO 2-1899.

If this

my

Again,

my

thanks and

my

regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>November 27, 1988
Sidney Malitz, M.D.
New York State Psychiatric Institute
722 West 168th Street
New York, New York 10032
Dear Sid,

It was kind of you to nominate me for membership in the Royal College of
Psychiatrists. Alan Miller was pleased to endorce the nomination and the papers
went off promptly on Wednesday.
My

best regards.
Sincerely you rs,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>"’f‘mm’w" 'un-W‘

:r’alww .mu-zw—a—wwq-p-mvm

w-“

July 3, 1970
President
Mallinckrodt Chemical works

St. Louis, hissouri
Dear

Sir,

Since 1968, we have carried out clinical studies of
naloxone in the treatment of’opiate dependence. Supplies have been
provided by Endb Laboratories, but they have been unable to
make sufficient nalosone available for oral studies. In December
we requested additional supplies and these have not been forthcoming;
they have indicated that the supplies are male in your laboratories.

In discussing this with the officials of the New York State
Narcotic Addiction Cbntrol commission, they offered to make funds
available for our independent purchase of'naloxone; and such a
contract has been received by this Department.
would like to purchase 3 kilograms of'nalcxone; preferably
in 300 or 500 mgm tablets or capsules. Is it possible for
your laboratories to make such a quantity available? At what cost
we

made up

and with what delivery schedule ?

are unable to supply this quantity, can you direct
If youlaboratories
either here or abroad that can ?
other
to
us
an...

We

am..-

'1

--

either

U.S. customs,

have

or can obtain the necessary

etc. clearances.

FDA, BNDD,

my".

Thank you.

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

mf/
cc:

Endb

Laboratories

�</text>
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                    <text>my

29. 1973

EEGJenr-nel

Eleevier‘

halterden
Gentienenej
‘

1 have moved my

laboratory to

reqeeetthee the subscription represented
be cexit1n‘ued, but addressed to:
'

a new locat1on,

by the attached

I
lebel
and

.

_

_

‘Dr. Max Fink
HSGuDepertment of Psychiatry
sun! at Stony Brook
.Stony Brook. New Yetk 11790 U. 8.A.

'lhenk you.
’

'

‘-

'
..

-

b
.
&gt;

,

.

.gtmereiyfhun,

nu mg;

VPeoteEsqr

m
of Psychiatry
,

.

�</text>
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                    <text>September 24, 1968
Dr. Arnold J. Handell
Department of Psychiatry and Human Behavior
College of Medicine at Irvine

Irvine, California

Dear Dr. Randell:
Thank you for your kind invitation to present a report
of our current electrophysiologic work in relation to psychopathologicsl states. I very much agree with your mission of
honoring Bob Heath for his stimulating work in schizophrenia,
and I would like to participate.

nest relevant problem is the repeated observation of
differences in EEG response to barbiturates (sedation threshold
and pentothsl threshold) among different populations. The 1961
suggestion that unresponsive schizophrenic patients show their
The

lack of response to most psychoactive agents by a lack of response
to injected pentothsl has been under investigation in Missouri and
New York since 1963. The methods of analysis of the EEG have
turned out to be more complex then we first anticipated, so that
the real data available today is still meager. Nevertheless,
if the Program Committee wishes, we would be pleased to review
the problem of responsivity to barbiturates as an index of
dysfunction (altered function) of the central nervous system
in severe psychosis. we can present the recent mathematical
models for responsivity and summarize our recent experiences
in a therapy resistant study in St. Louis.
A

Mbdel

provisional title: Present Status of the Cerebral Reactivity
in Schizophrenia. The report will be written by Dr. Turen Itil

and myself.

Again,

my

thanks for your kind invitation.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>A

w.

u

w.

.4

.“

-v—m

«Va-1.....-

vvarm-m'rm—w.

wwrwv-wu

awn—”rpm

December 4, 1968
wrzw'mrtrwv

nyx-Wiw'uﬂr'fina

v:

Dr. Arnold Kendall
Deoartuont of Psychiatry
Univ. of California at Irvin:

Irvine, California

J’f-‘l'llbr

r
H

.w

car—

Dent Arnold,

in"?

.

“.mu'rfz

.

.

rm”:

.
V

A; we diocuosod, I am enclosing thrco abntracts for the
consideration of the Fsogran Committee of tho Boeioty of Biological
Psychiatry.
and
and

will

The abstract on cetubral reactivity in the one toquostod,
be a review of tho pant for your: work in our laboratories

others.

The unilatera1~bilatora1 EC! is submitted to bring to
the attention of the Socioty son. of the new tindinga in this
reappraisal of the convulliva thetopy protein.

The maternal schizophrenia—sex of offspring report is
tho most important, potentially of the three; and probably fita boat
into the theme of experimental roooaroh in schizophrenia. I am so
impressed with the data that I on oncouraging thoso young residents
to write a definitive report and uubnit it for the prize contest of

the Society.

for a

Thank you for your considerution, and
moot successful program.

my

best wishes

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

M33

mil

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                    <text>Mann 7, 1959
Dr. Arnold

J.

Mamiell

Departmnt of Psychiatry
Hunm Behavior
Sdmcol of Hedicine

of California,
Wimity
California

Irvine,

and
'

Irvine

Dear Arnold ,

for your letter of Febzuary 21, indicating
two
abstracts for the Society of Biological
of
acceptmoe
am
delighted that two of my young associates
Psychiatry. I
able
be
will
to present their musual work on "Effects of
Thank you

Maternal Schizophrenia on Sex of Offspring."

I am writing, however, to ask if it is possible to withdzm
the papa "Cerebral Reactivity Model in Schiﬂamrenia A Roappraisal". Some of the work whid'x I, had wished to include
has met unexpected difficulties in the analysis and neither
Dr. Itil nor I think that we wand have sufficient mterial
available by the end of May to justify the presentation.
I regret my inconvenience that this my cause you.
Thank you for your indulgence.
-—

Sincerely yours ,
1% PW, MOD.
Professor of Psychiatry
Ifzkp

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                    <text>v.

.

mmsm.--mW—wwww...s-.ww.~...-.,.w

Septenber 3, 1970
Dr. Arnold

J.

Mandell

University of California,
P.

O. Box 109

San Diego

LaJolla, California 92037

owu—PWWrsw

.“ww...

Dear Arnold,
I look forward to seeing you in sunny California in February.
There are two topics under study here that would interest the Society.

l) Antggonists in Opiate Dependence: The conditioning model of
opiate depen ence suggests that ”do-conditioning“ could occur if self-

stimulations (needle + drug) went unrewarded repeatedly. Successful
treatment of opiate dependent subjects with narcotic antagonists
(cyclazocine and naloxone) provides support for this theory, and the
basis for a useful therapy in this and other addictions (as amphetamine
and alcohol) (presented with A. M. Freedman).
Convulsive Therapy:

2)

Recent modifications of convulsive therapy

(unilateral convulsions, multiple monitored seizures, inhalant induced
seizures) have focussed interest on the relation of memory change,

altered brain function (EEG) and behavioral change (improvement).
Unilateral induced seizures produce significantly less change in various
asymmetric EEG changes and equivalent behavioral changes
to bilateral induced seizures. This dissociation of therapeutic and
”side" effects allows multiple seizures to be given in one sitting -

memory

tests,

with therapeutic benefits. These observations are of interest to the
theory of convulsive therapy and to the relation of brain function and
tests of memory (both immediate short term and delayed).
I
My

trust that either topic will interest the

members.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>Decaubor 6, 1971

Arnold

J.

Mandall, M.D.

Profoaoor and Chairman
Dopartnant of Psychiatry
Univaraity of California

P.O. Box 109
La

Jolla, California

92037

Daar Arnold:

It waa kind of you to writa about 8-2809, a bill sponaorad by Senator Tunnay. I had read thia bill before and found
its intant coat worthwhile. Tho meant, however, carry two potential (and unnecessary) pitfalla - a focus on a limited number
of ragioual contort, and tha incroaaad focua on a political aourcc
of control, notably the white House.

copy of my roaponaa to Senator Tunney is enclosed for
inforlation.
At this time, support for the aatabliahnant of a national
A

your

institute for drug abuse raaaarch and training seams to be sorely
noadod. Sanator Tunnay'a bill ocean to diffuae tho energies foam
this important effort.
Hy

boat ragards .
Sincoraly yours.
Max

Fink. H.D.

Professor of Psychiatry

Ming
Ibo.

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                    <text>December 27, 1993
TO:

F aroukh Maneksha

George Petrides
From:

Max Fink

Subject:

Follow—up

on trimethaphan study

Now that the dose range of trimethaphan has been deﬁned, we should use a
similar design to study the relative efficacy [and safety] of a beta-blocker compared to
trimethaphan.
Attached is the output of abstracts from a search of the ECT Database for
the substances labetalol, esmolol, and nitroglycerine, post-1987. Would you review
these and select one as a contrast for trimethaphan? Can you define a-commonly used
dose? Is there a design that you favor?

�</text>
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                    <text>July 20, 1979
John Mann, M.D.
Department of Psychiatry
New York University College of Medicine
New

York City 10016

Dear Dr. Mann,

I

returning the EEG samples sent me. As we discussed,
these samples seem to represent the four montages of a single session
in each of four subjects. It is not possible to determine 'drug effects'
from such a sample, and when you reach the investigators again, you
may indicate that the need is for serial records, taken with bee same
montage, preferably at the same time of day and with some control for
the state of vigilance of the subject. (It does us little good to
get records with subjects asleep on one occasion, awake the next; one
hour after dosing on one occasion, and six hours on anther; etc.).
I am sorry about the crossing of the two protocols for the
study of depression, but look forward to your combining the best of
both. Let

am

me know
My

what tou decide.

regards.
Sincerely yours,

v

.,

.
v

.
..‘.v..:..

w,‘.,_,-,-.~.,..v

”A

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Septeﬁber 13. 197k

Alfred Freedman,

D.Cheirmen. Department of Psychiatry
New York Medical College
106th Street and Fifth Avenue

New

M.

York, N. Y. 10029

Dear Al:

I

am

Enclosed

is

pleased to acne

a complimentery copy of the EST volume.
to you with gratitude IOr your support

it

interest in this project. I regret the delay in getting it
to you, but I was confident that it had been sent as part of the
original mailing.
and

I have received a request for a

copy from the APA
museum, which I an honoring at this time. If you have any clout
with the APA Hewsletter, perhaps they would recognize the publication of this volume under their new books published, especially
if an appropriate description could he added.
My

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

HF:ed

Enclosed

�</text>
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                <text>1974 </text>
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                    <text>WrﬂaV‘m‘m

w

Wvuv—u—r.

2m

“0"“,

w.

A,

m

May

5, 1980

Dr. Salvatore Manuzza

Senior Psychometrician

Child Development Clinic
Long

Island JewishéHillside Medical Center

271-11 Union Turnpike

Glen Oaks,

NY

lthO

Dear Doctor Manuzza:
The

literature

on ECT, including my own

large that I wrote an exhaustive review in
sent to the Heany Lorand library.
so

contributions,
1979.

A

became

copy was

You may also wish to see the APA Task Force report #lh published
in 1978. Between the two volumes, you should get a good grasp of ECT
issues for 1980.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:sl

�</text>
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                    <text>~.':—_r~—

.—

mvw-mi...

F-"vH-v'v

F'm'mmwu-

WW1

June 11, 1963
Dr. James Margerison

Institute of Psychiatry
Derunark Hill
'Ihe Maudsley Hospital

London, 3. E. 5, England

Dear Jim:

our EEG laboratory is in spemtion and we are now
admissions
before the drug induced changes. The
screening all our
computer mit has also been installed and we have been making up scam
programs for the time series analysis suggested by Neil Burch. I am
learning how to talk to this instrument and we expect that the AD
converting systems will be available in early July. If things grm
at their present rate, we should be able to carry out concurrent frequency
analyzer and computer analysis of EEG by September.
At long

last,

p

'

I have received some excellent moormendations concerning Miss Walton
and have offered her a position. Thank you for your momndation.

MyoummhereImayhave toldyouthat

Dr. SamGershonwas

joining the Institute staff. Dr. Gershon, who has come to us from Australia,
has been interested in Lithimn therapy and its effects on electrolytes. I
brought your studies to his attention, but he already knew of them. One of
the studies which he wishes to undertake is a reassessmnt of Lithium therapy
in manics with concurrent studies of caleimn levels in phases of depression.
Another program which is of special interest to me is the study of Ditran
and its blocking agents. For this latter study, we are interested in analyses
in spinal ﬂuid of acetylcholine and clalineestemses. While we have some
good ideas and can carry out the clinical and pharmacological studies, we
are at present, stymied by a ladc of a biodmmist who can carry out such
investigations. It is at times like this that :1 regret your decision.
In the event, weaver, that any of your biochemical friends are interested
in spending some time in the States, participating in such a program, I should
be grateful for your recommendation.
.

,

of

Diswssions have already begun

CINP.

in the States regarding the

meetings
hape that our laboratory will be represented
meeting and look forward to visiting» with you again. My best regards

at that
to Sheila.

If .at all possible I

Sinoemly yours,
Max

MF:aw

rim, n.

Director

D.

,

1961+

�</text>
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                    <text>August 26 , 1963
Dr. James Margerison

Institute of Psychiatry
The Maudsley Hospital
Dermark Hill

London, S.E. 5, England

Dear Jim:

last

met productive and, at long last, I feel
It has been a year since I visited
England and I still recall that trip with great pleasure.
Miss Walton has started to work with us and, as you and the other referees
indicated, who is a conscientious worker. There may be some difficulty in training her in the use of some of the newer equipment which we now have, but Dr. Itil
likes her and I think she will mrk out very well.
The

that I

am

few months have been

getting back to the laboratory!

»

V

Dr.

Ulett received a letter

from Dr. Driver reconnending

the consideration

of Dr. Serafetinides for a position here. George asked me to" handle this and
I have written to him, separately, suggesting that he discuss with you your
visit to our laboratOries. In. the event that he is interested in joining our
staff, I have asked that he send me a. copy of his curricular: vitae. ; In; addition,
I should be grateful for your mommdation cmoerning' the“ pessibility of his
making a contribution to the development of our units.
Our computing unit is now fmctioning- and my own facility is increased to
a point where I have written some simple programs. The first project was to write
a period analysis program, following the model of Neil Burch. This-has been done
anditworks verywell. WearenwabletotakeanBBGandoarryoutallthe
steps of analysis up to the final drafting of the graphs. We are now trying to
deveIOp some simple style procedures that will handle the large number of calcula—
tions and provide us with some simple measures of the changes of the EEG. The
major advantage of this form of analysis is the apparent dependence of frequency
and mnplitude, as well as the ability to reflect changes in frequencies higher
‘

"

than 30 cycles per second. Of course. with such a sensitive method we are now
faced with the problems of our amplifiers and find that the frequency responses
of even the newest and best, is limited to a small band. We are going to apply
this method first to the simple problem of defining the changes in pentothal and
as soon as I have some definitive information, I should be pleased to send it to
you

for your
My

connnents.

best regards to Sheila.

Sincerely yours,
Max F111}; M. De

Mfzaw

Director

,

\

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                    <text>October

1‘}

, 1963

Wm
of

Dr. Jams H.

Imtitum cf Psychiatry

Dapartmnt

Wall. Emmy

The Mmdalay Hospital

Hill
Wk
warm. 3. E. 5, England
mar Jim:

mingﬁmsepmt

{hm follamdupthemowmdau
fwm
mum
u
mtg

indeed very
titan of Dr. Semfeﬁnidas. I
for yam
of your hesitancies.
as subsequent inquiries atmatantiamd

ﬂanks.

m

Ihave just mtumodﬁmme AmricanEEGmtm.

63th

mny

Agood

portion of the time was
to reports about automtia EEG analysis and the application: of averaging techniques. I fame! that the

mmndod waEGamlysism innovay superiorto
Mum
cam. Dmingthepast
wmmuﬂaomwin
probably

.ﬁmmﬂm.mhawdovelopodbothﬂuoquimntmdmmcmim
BBQ with
1710

m

to use the me
computer for the analysis of
mm
models: Period Myth (W), Power Spam, and
than

W
inasmllatﬂymmeffcctofﬁntoﬁnlinmcmzomﬁm.

auto-am!

accumulation.

to gut mmifioent

wall.

ms

While um equipmt
which mﬂwt subtle

It is w hop. that we will Wmte

is small. I

am able
with drug wry
the value of those named:

nowinprows. Sam
amofmumhpmjem
omtinmdwithﬁmpmbhaefbloeldngmnts to Ditmn,

Thoreau

What
Maddalsm,tnhadaatudent amt
mmmmmm.
a mplimim of Dr. deam's report on dift‘mnoaa in louoocytes
in
patients. Of me, he was unable to cmfirm this
sﬂWa
an.
war-v

�Dr. Jam 3. Margarine!)
Octobar 1%. 1963
Page Two
50 Wemhizophmicsmﬂasmllw
www.mhaw
mania
mmtber of
patients. In the ehmic schizophrenics. m are in.

tomted in determining the extent to which chronic brain dysfmctim
mists and may be a factor of their poor
response. These

thc extent to
failums are a Wilma
ifWtic
mm
whidmnrmiabminsyndrmsmafactor. Ibeliavewemaybeable
the efforts of am mute mm centers in a m satinto
factory
and

we can

(lemming

focus
fashion.

mm

is repeating his Lithium
of Victim blood
study.
hum,
m.
(This
oatims War a ”strict" dietary omtml.
is, of came. the
In the manic patients. Sam amber:
introducing

We

most

a

difficult part of the study).

mmbeensurveyingﬁaehospitalpopuladmtobdngm
of.

opiloptim and is 1:1th in thc relammthdvpasts—Waited
EEG cramps ta their waviw.

t‘ien of

all of this. we we assassins the valuc of mm13mm
zineinmmpofpatimta. Inmtrnr.mlnvetalmnthcmoffall

ugdioatim and anticipate very

on,

little dung. if we hep

them

of! medica-

Ithasbeenafullmsinmxcmtomsswimdmllook
Imamtlmwillalwaynboaplmmrymifywmmmwayclear
tosponding smatimintmsutes.
mmfwywhelp. wmmmgmmsmm.

aboutmlmdelighmdthatmhaveanopemtingm‘gmiutim. Anya:
Y

3mm yams ,
Max

Fink.

Dimtw

MFzmlg

H. D.

�</text>
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                    <text>October 28, 1963

Dr.

Jams Margerism

Institute of Psychiatry
The Maudsley Hospital
Denmark Hill

londcn, 8.3. 5, England

Dear Jim:
As

the

"mfficial British consultant to this Institute"

(a dubious honor with which I hereby invest you). I muld appreciate
your accepting the following chore. I have received a letter from
Dr. H. Lentin, a copy of which is enclosed. I have taken the liberty
of asking him to call you and would he most geteful for your meats
regarding his personality, his mason-13 for coming to the States, and
an estimate as to whet cmtrimtions he could make to the clinical
in the Institute.
research

prom

'

If he does not appear suitable formy shop, we do have Opening
State Hospital for clinical
the
at
‘If you think he might
be suitable for that role, I would appreciate your cements.

pawl.

Sincerely yours,
Max

Mfuw.

enc.

2

Pink,

Director

M.

D.

�</text>
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                    <text>‘3

13w ’3‘“
’5.

,,

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v:
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(3,;

n

‘

Km
Dr.

Jams

16 , 1983

We:
of

H.

Wu

Imtituta 0f Paymiatry

Dam:
Nauru].0W
The

Why Hmpital\

Wﬂiu
W5. E. 5, England
Dear Jim:

I

am

very

mtoful far your letter regarding

Dr.

In the swam past. I received a latter from him, and ha
very enthusiastic about aiming to the unipd Status. I

man.
am most

mtﬁulfwymrinlpinﬂdam.
albawhadanmw
Inhmldbom’c mum ierculd callm'you
mum”,
again.

Inthismmylmtmﬁmkwawphcingtmm
Mamidamluwmsmdand
Whmmam.
NW may. 8mm
tom mum
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chntiala.

of

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appears

tar. Ihavawittmmm.arxiifs}misintmmd,1hawmgo

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m11yw.!m1dapmcimyummm.

Inmaﬁmletm.1mmlmmtamdﬂutymm
amappaintamt.
Immtwmtidwiﬂtyweffmtamlop
amdaparmnt,fwthispmtmhmbomawminiamﬁw
ﬁlms.

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‘

�Dr. Janna H.

Morison

November 16. 1963
Page Two

for'indncdthmis
Ian plmdﬁmtymlavesnnwhom.
The
be

Superintendent
memgssibility that I may caning to mallard.
and
has
Dr.
Ulett
replaced him with a
hospital has resign!
with
research
experience. In an effort
very fine yomg psychiatrist
the menial, advertisefor
to mnruit more qualified psychiatrism
British
Journals. If the umber of replies
manta have been planod in
would
probably be advisable for me to visit England
are sufficient, it
few
days to carry out the intervlcmng in person. In the meanfor a
time,IIshould like to be able to call on ya: as the need arises.

mutant regarding the analyzer output being nonlinear is
quite newest. We have recently challenged two analyzers and detsmimd
tbst there is a sharp fall—off when voltages are less than one-half the
the assmnptim in Hnuslsr' s monk, and others,
calibrating voltage. I third:from
subject to subject are identical. If
is that the basnhm records
indeed
classified according to the pmtmammnt record slursubjects were
with
actnristics , than paramtmc statistics may be applicable. However,
1'
think
the more com disregard of the pretreatment characteristics,
yam meat is quite newest. Wing the last few months, we have been
using a digital oanputsr to determine the
spectrum in the mmbnr
of our records. I have satisfied myself ﬂat the amplifier and the conversion mthode are linear up to 80 cps. I have an additional program
from Neil Burch for baseline cross-analysis, and will, in the next few
months , carry mt a oomparism between the two techniques in order to
dotemdne the conditions in which they are simla’r and dissimlar.
Your

pm

I have just received ycmr article with Barbara Tizard, and should
have an opportunity to read it in detail before consenting.
Sincerely yours ,

-

Mleg
Ens.

M.
Director
MEX

Ms

D.

�</text>
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                    <text>(w)
git-7f ;

December 27, 1963

lb. James Margerieon
Institute of Psychiatry
The Maudsley Hospital
Demnark Hill

London, 5. E. 5, England

Dear Jim:
New Year. Again, I am writing to ask
did
Dr. Lantin. The other letters which
with
us
you to help
as you
he receiwad regarding Dr. Lantin were such as to lead George and
My

best wishes for the

myself to offer him a position

at the hospital, with the idea that
other
after a year,
things warmting such a transfer, transferring
him to the Institute.
I

have recently received an application from Ir. Alexander Don,
formerly of South Africa, who is now at Werley Hospital in antwood.
I am taking the liberty of writing him and asking that he call on you.
His cmiculmn vita is enclosed. Would you be so kind as to let us
have your Opinion again?

I have also received another letter from Miss Carole Warner
and have urged her to call you and have you to, perhaps, also provide
me with an estimate of her personality.
My

best regards to Sheila.
Sincerely yours ,
Max

Knew

enc.

Pink,

Director

M. D.

f“

53»--y‘w._..w§ga.«»~,-,x

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                    <text>January 29,

196i;

Maison

Dr. Jams

Institute of Psychiatry

The Mandalay Hospital
Denmark

Hill

Lemon, S. B. 5. England
Dear Jim:
About a nonth ago I wrote regarding an application we
moaivad from Dr. Alawxder Don. His credentials were excellent
fmm meessor Hurst of
and I have recently received a
SmthAfricawmgavehimavcxyﬂmmmndaﬁm. 1am
amdcus tapmcossthis furtrm,buthavcmtheardeimrfm'

lam

.

him car from you.

Hm he contacted you?

himmmybemlf?

If not.

wwld you‘ocmaimr caning

Mammabkimgular.butlamfamdwdm‘
of
the

a choioa at the present tin» of

wounding

appointmnt

a

psychiatrist such as Dr. Don, or using the same fmds for a warmcolomt who is intemted in caning in September. It would be
helpful for m to law meme)? ha is intemtad, and whether I
should process this further.

Wﬂunksammbostmgm.
Sincerely yours ,
Max

Pink,

133.th

Mleg
Alexanchr

M.

Don,

Harley Hospital

antwood. Base

England

,

M.

8.

M.

D.

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                    <text>February 14, 1964
Dr. James Margerison

Institute of Psychiatry

The Mandalay Hospital
Denmark

Hill

London. 5 age 5’

England

Dear Jim:
was pleased to receive your letters concerning Drs. Don and Lantin.
had already received a very excellent letter from Dr. Hurst concern—
ing Dr. Don, and have just offered him a position at the Institute.

I
I

may than“ a

Dr. Lantin's hesitsncy in joining the hospital staff appears to be
considerable, and I have followed your note with a letter of my own,
indicating the extent to which this community does have a large Jewish

pupulation, and the integration of the Jews in the community.

on you once again in that I have just received'
George Shaw, whom you may already know since he
the Mandalay from 1956 to 1959. A copy of his c.v.

I would like to call
application from Dr.

registrar at
is enclosed. and I have taken the liberty of writing to him, suggesting
that he call you.
I have, within the last week, received an invitation from the CINP
program committee, to participate actively in the 1964 Birmingham
meetings. I accepted gladly, and now look forward to being in Europe
during most of August and part of September. For this reason, George

was

and I feel that it would be unwise for me to travel now. I have urged
him to join me on this trip and I think
may be possible that both he
be
and Turan
in Birmingham during the
well
as myself, will
as
week
in September.
first

it

Itil,

I

would be most pleased to have an opportunity to

visit with

you

either

our plans are
before or after that meeting.
Martha hopes to join me for part of that time and, with some good fortune
in our finances during the next few months, I hape to be able to visit
Israel as part of our holiday.
My

As

now

being developed,

best regards.
Sincerely yours,

MF/jb
Enc.

'

Hex

Fink,

Director

M.D.

�</text>
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