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                    <text>1,. 431(1).
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New York, ﬂew York 10029

October 21, 1969

ﬁr. Benis Leigh
Secretary-General,
Maudsley Hospital

World

Psychiatric Association

Denmark Hill
London 5 S.E., ﬁngland

Sear ﬁr. Leigh:
For many years I have been interested in the applications

of electroencephalography to psychiatry. At the 1961 World
Congress of Psychiatry 1 chaired a symposium on BBC and woman
PsychOpharnecology, which was summarized in the EEG Journsl,

In subsequent years, meetings of psychiatrist ~
electroencephalographers have been held in association with
1963.

the Society of Biological Psychiatry, the
in rushingtoo and the latest, in association with the
International EEG in San Diego. This latter meeting was held
in my laboratories in New York on September 25, and was attended
by 24 visitors from nine countries.
It was the consensus that
similar meetings should be held and ideally the members agreed
that the Worlé Psychiatric Association represented the best
the

CIR?

German ClﬁP,

forum.

Recently, Br. Jonathon Cole brought to my attention
the fact that the EPA has established sections on diverse
aspects of psychiatry. Prior to my discussion with 9r. Cole,
I had written to Dr. do la Fuente regarding a symposium on
EEG and psychiatry during the Vth loternetionel Congress in
Mexico City in l971. He expressed interest in this suggestion
and plonned to discuss it with the Executive Committee.
of

1

EEG

an writing to propose the establishment of a section
and Psychiatry within the world ?sychiatric Association.

It is my belief that there is general interest in the applications
of this tool, developed 40 years ago by the psychiatrist,
Dr. Hans aergor, and I believe such a section will not only be
productive for the scientists directly involved, but also for
the many psychiatrists of diverse interests who attend the
world Congresses.

Hey I have your advice on how

to proceed?

Sincerely yours,
ﬂex Fink, M.B.

Professor of Psychiatry

MP :32)?

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                    <text>July

21 , 1970

Mr. Joseph Lelyveld
New York Times
New York, New York

Dear Joe,

this opportunity to express my personal
thanks for your assistance and efforts in reversing policies
of Endo Laboratories in the production of naloxone. Your
inquiries served to alert DuPont to the public health importance
of this project in a way that we could not accomplish.
I want to take

vp.-v-r"-V

v-

WW.“

wry-7*

n

p,“

Enclosed is a copy of a letter I received from Mr. Jerome
Serchuck of Endo Laboratories, confirming that they will supply
naloxone for the next phase of the clinical studies.
My

thanks for your fine

article

and your

assistance.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
811C .

....Y

‘.
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“n"r'L-ur'CSQ‘IF'YI

)axwzmlmrvnnv

I"

,.
r'J'FI'!

writ-9‘

FWI‘Wﬂ'ﬂr—vz“

�</text>
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                  <elementText elementTextId="103338">
                    <text>W'xwm\;m.

v.

-W:w:m"r

xwx

wrumnra

um.

we

N'Ixr’m.

we".

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m",

t

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.

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July 10, 1970
Mr. Joseph

Lelyvald

The New York Times
229 was: 43rd

New

York,

New

Street

York

Dear Mr. Lelyveld:

I was pleased to have the opportunity today to continue our
conversation, although, I must admit, that I was distressed by
the turn of events.
of the June 4 meeting on Mucous Antagonists in
Opiate Dependence is enclosed, with s list of participants. This
summary has been accepted for publication in Science.
The summary

We

have been

notified by representatives of the

Endo

Division

of DuPont — Mr. Joseph Conlon, Vice~President of DuPont and two
associates — that they would no longer support studies of naloxone
in the therapy of opiate dependence; specifically, they would not
approve studies under

tion) before the

clinical trials.

FDA,

their

IND

(Investigational

nor would they

make

New Drug Applica—

supplies available for

I indicated that we were prepared to purchase a supply sufficient
for our immediate needs, 6 kilograms, at an approximate price of
$10,000 per kilogram - a price suggested in 1969 by Mr. David Kline

of Endo Laboratories.

since

,um‘u

"W”,hwm‘

”new: rnmmm-qvvv-mqu-"w-,m-.-.._.....,

a

.

it

was

Mr. Conlon asked us

unlikely that they

would honor

Our request was sent today, and a copy

copy of a

not to

it.

make

this request

is enclosed. Also, a

letter sent to other participants of the

June

4

meeting.

is to obtain supplies of naloxone for clinical trial.
either Endo or DuPont in their une
Any
decision.
help
you can give us to attain our primary
fortunate
be
that, we will cooperate fully
Failing
appreciated.
goal will
American
Our aim

We

have no need to embarrass

to make the complete antagonist story available to the
press - a story with many strange and sordid elements.

�~2‘

Hr. Lclyvnld

hnvc 1130 brought this issue to tho attcntton
CBS Noun, a friend and follower of our work,
havc Icrvcd an ad hoe consultant: on nu-crous occasions.

Incidcntclly, ﬂ!

chll

of Mr. Burl
and for whom

v.

of

Thluk you in advance for your holp.

Sinccrcly yours,
Pink. M.D.
Professor of Paychiatry

Max

ﬁrzkt

July 10, 1970

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.—,....,.A

..

December 17, 1968

Honorable Norman P. Lent
Chm.,

Joint

Committee on Health

State Capitol

Albany,

How

York

Dear Senator Lent,

I am writing to roquest sarious consideration to the
potential hassrds in tho proposed amendmont to the public health
law in relation to human research (8. 4015A, A.5586A). I have read
the proposed amendments and find them too restrictive in their

text with regard to the continuation of research;
definitions of 'roscsrch'.

and too vague

in the

Since 1952 I havo been engaged in rosesrch in montal

illnesses. with specific sophssis on treatmouts using biological methods.
First at Hillside Hospital in New York (1952~1962),thcn as tho
director of tho Miaaoori Institute of Psychiatry (1962~l966) and

at the New York Medical Collage whore I am Director of the
Division of Psychopharmacology and Drug Addiction. I have found that
none of the techniques which are needed in the study of man van be
carried out in animals. neural illnesses soon peculiarly human
frailtieo, and their study, while raconmonded it animals by others, are
totally unsuccessful. Progress in treating the mentally ill seems to
cons only from studies in patients, as with convulaivo therapy,
the many now drugs, and recently, in the treatment of opiate addiction.
now

At present, our emphaais is in the biological troatment of
opiate addicts. The peculiar nature of the illness, and the methods
which are now useful ( methadone maintenance, cyclsrocine and nsloxone
antagonism) have been developed in patient studios.
The proposed law suggests that all studies will have to be
cleared by a committee, half of whom will be laymen. Considering the
difficulties with methadone maintenanco with Federal authorities, and
initially with state authorities, I am sure that such a committee will
prevent any research which at the timo may be considered hazardous,
thereby preventing progress.

Lot mo cite a specific example. In our studies of mothadouo
inttho traatment of addicts, we have measured the affects of methadone
on brain function and find that the changss ara so like some that
we have found useful in the treatment of severe schizophrenic
patients,
that we proposod a study of methadone in the therapy resistant psychotic

�Senator Lent

December 17, 1968

2

pationta at our institution. The proposal was carefully reviewed
by our College committees and approved. 0n referral to the Commissioner
of hospitals. howovor, the proposal was dioapproved since mothodone
is considered an dddicting drug. It is strongo that laymen are
for when all hopo has been
willing to allow the severe montally
nbandoned after all other mthodc have been tried, to forgo a potential

ill,

therapeutic benefit, out of fear.

All research must be daring to be oudcasaful. All human
research can ho monitored by our poets, and the present committees
have shown themselves to be useful. Since their introduction during
tho post foo years at the urging of the Federal granting agencies,
it aaams premature to antablioh another mechanism bofore this one is
‘fully established.
Specific objectiona to the logialntion are as follows.

will consint of laymen in the majority. Modern
too
complcn
to be rovicwed by tho laity except when one
tachuiqcos are
hoscl
no
oxpocts responses
prejudice and emotion. Research cannot be
omotion
and
be judgod by roaaon«~ whcrovor poooiblel
should
by
judged
The Comoiosion

will oit far away from the site of tho
rosoarch. It goons that there will ho only one full time mentor, and
it is inconceivablo tact tho alto of the roooarch. tho qualifications
of the investigator, and the Quality of the protective devices can
The Commission

be monitored omcoyt in tho locale ohcro the study

is done. If a committee

of visitors is established, than the device will be overly cunbersono
and oxponoivo.

conflict hatwocn reoearohy at poorly dofinod, and
medical
treatmont as
practice, is not rcoolvod by the logiolntion.
If I treat a patient with a new treatment will this ho exempt if
I on paid for it as part of medical practice; but not exempt if
done for no fee as part of a research program ?
The

The problom of consent has been adequately discuoood
Fodoral
in the
legislation of a tow years ago. Thorn are special
problems in dealing with the mentally ill, and the propooed atote
legislation does not dofino the safeguards which experience has shown to
be useful and necessary.

There are othor problems which are not

clarified in the

bill. It is regrettod that tho legiolnture finds it necessary to
propose state legislation io.an «tons where existing legislation.
if adequately administered. would be most odoq’nto to protect our
fellow citizans and ourselves. American research has been in the
forefront in all fieldo except in the care of the mentally 111. Most

of the modern advances in their treatment have coma from Europe. In
part this resulted from our ovcrinvoatmont in psychotherapy; and
in port. from the restrictions placed on research in our institutions
for the acuto mentally ill. The addition of this burden, on oxemplified
in tho proposed lcgiolation, will handicap Amorican research even
further- for such legislation is unlikely to remain restricted to
our stotc. since we have been a bollwoathor state.

�Senator Lent

December 17, 1968

3

In writing this

letter, I

on

acting

on my own

behalf

as Director of the Division of Psychophnruaoology and Drug Addiction
of the Department of Psychiatry; and as tho Exocutivo Diroctor
of the International Association for Psychiatric Research. Inc. The
IAPR was established in 1967 to provide a nochonisn whereby collaborative
research could be undertaken in othor localities where the restrictions
were less stringent. Because of limitations in committee actions
at the Federal level, we have undertaken some important research in
trottnont of mentally
in Istanbul, thoroby confirming studies
We hnvc also begun a study of
from
France.
originally reported
marijuana in Greece since the restrictions imposed on the study
and sunply of this impotttnt agent in the United States have been
so great that wn havo had to go through multiple oomnittons and
18 months delay before undertaking ouch studios in New York.

ill

Your consideration of these comments

is appreciated.

legislation will, in our opinion, do more harm to our
citizens not ouroolvos than any potential good that may be imagined.
Your oomnittee's disapproval is roquooted.
Tho proposed

Sinceroly yours,

Fink, PhD.
Profossor of Psychiatry

Max

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                    <text>February 17, 1996
Ms. Sarah Lentz

DMS Box 470
Hanover, NH 03755
Dear Ms. Lentz,
Thank you for the opportunity to read you report on ECT and pregnancy.
It is quite good, but as an Editor, I have some suggestions to improve the history and the
practice.
In the history, the introduction of electrical inductions by Cerletti and Bini
was a modiﬁcation of an established treatment, that of Metrazole convulsive therapy. The
induction of seizures with camphor and then pentylenetetrazol [Metrazole] was introduced
by Ladislas Meduna in 193 4, highlighted in an international conference in Muensingen,
Switzerland in 193 7, accepted throughout the world as a treatment [see the supplement to
the Am J Psychiatry 193 8]. These events preceded and were surely the stimulus to the
Italians [Bini attended the 1937 meeting]. It would be better to state that the introduction
of convulsive therapy by Meduna was the innovation that altered psychiatric practice. He
deserves the credit.
The charge of overuse and inappropriate treatment of ECT is incorrect. All
treatments that are perceived as successful and safe are ‘overused’ as practitioners seek to
extend and deﬁne the indications. Think of the present enthusiasm for ﬂuoxetine or the
newer alleged psychotropics; or the extensive overuse of coronary artery bypass surgery;
or of caesarian deliveries. The canard should not be repeated and this section should be
deleted.
Further, ECT like other somatic treatments in use in the 19505, was
replaced by medications, but its renewed interest [in contrast to psychosurgery and insulin
coma] was occasioned by the failures of pharrnacotherapy. Despite the enthusiasm of the
public and the blandishments of the pharmaceutical representatives, many patients fail
modern drug therapies and are later successﬁil with ECT.

�In your suggestions about ECT in pregnancy, there are a few that are more
dangerous than you consider. Vaginal examination is not only not necessary but a
dangerous procedure during pregnancy and should not only not be recommended, but
enjoined unless compelled by signs or symptoms that warrant such an examination. There
is nothing about the examination that would alter or affect ECT, if ECT is compelled by
the patient’s mental state.
Anticholinergic medication as part of the ECT procedure is acceptable and
useful. External fetal monitoring during the procedure has been done, and remarkably, the
fetal heart rate is unaffected by the procedure. There is no justiﬁcation for such monitoring
as a routine procedure because the expense is excessive and the information yield nil.
In patients in the second half of pregnancy, intubation is part of the
standard of anesthetic care, and it is routine for all our cases. The use of antacids is
optional and our anesthesiologists no longer ﬁnd it useﬁil.
I am puzzled by the CME credit questions 2 and 3. ECT is indicated during
because
the patient is so psychotic as to require hospital care and is exhibiting
pregnancy
either suicidality, mania, inanition, or command delusions which threaten the life of the
mother or the fetus. The emphasis on diagnosis does not reﬂect the compelling indication
for ECT, that is behavior which puts patient or others at risk.It is not the diagnosis that is
the indication; many mentally ill mothers cany to term without medication or treatment.
Question 3 is ambiguous. Each of the modiﬁcations of procedure are
relevant to the care of pregnant patients.
Aside'from these quibbles, I commend you on your report. We are now a
main center for treating pregnant psychotic patients and treat at least one a month. Two
are in treatment now, one for severe depression and suicidality and one who was in manic
delirium. The ﬁrst is continuing in ambulatory treatments and cares for her other child; the
second has just had the delirium erased and is still being treated for mania and psychosis.
Good luck in your career.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

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                    <text>October 30. l967
Dr. Abe Lonzner

l Sussex Road
Great Neck. New York
Door Abe,

It was kind of you to send me the latest issue of the
Jouhuai 05 the Hitzoide Hoopitni. I had not read it before
but did so this evening and found it most interesting. Since
coming to New York I have assumed responsibility for one of
the narcotic addiction study programs at New York Medical College.
The report by Dr. Sharoff in tho volumo describes the
as
it existed last year. I regret that he did not reoortprogram
on the
first group of methadone treated patients at Metroooliton Hospital,
for his data would have supplemented that prosented by or. Solo.
Since that report, we have undertaken a study of cyolazocino
as a adjuvant to the treatment program, and found it most useful.
I am taking the liberty of sending you a copy of the
report which
recently appeared in the J.A.M.A.
a new

Perhaps even more interesting, is our recent experience with
anti~narcotic, naloxone which seems to have fewer side effects

than cyclazocine.

I look forward

Again,

my

to seeing you at the divisional meeting.

thanks.t
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>War 29, 1965
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Bur-Abe:

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ofdzugnddiatimmquuiusupriudtomﬂutyouhavc

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mticipatod.

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www.mwmmtmmmsputmatm

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MYoﬁcmfmqmﬂymwﬂthadintmmtfawW.

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Max

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HA).

meecaor of Psychiatry

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mwsmwnnuw».-.mw.

.

V

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V

,.

.

February 4. 1966

Abram

So

“unat.

11.9.

Nassau Academy of thicine
1200 Stewart Avenue
Garden

City,

Nan York

Dear Aha:

for the bullotian. Th: prtscntation
is excellant, tad carries the hallmark of your own intuit—

Thank you vary much
.

ablo style.

That. 1: an active program in post gtadunta cducutiou in
St. Louis which is under the aponsornhtp of Dr. Ed Aunt,
who 15 tha Chairunn of tho Department of Psychiatry of
st. Louis Univcttity. I have takun thc liberty of sending
your untltna to him for his information.

past years have been challenging, and it has bean only
in tha last few month: that I havu found the time to get
back to tho laborttory. We have many unit: an» in operation
and with son. good fortune, tbs productivity of this center
will match tho visions which I had for Hillside.
The

Martha and tha children are well, and seen quite acclimated
to the Nidwast. Martha has complettd he: first nounstnr
toward her unutcts in education, and she ht: accnptod tha
challungc with a good deal of pleasure.
ﬂy

but: tagarda to all our frinnda.
Sinccrely yours,

m wink, n.3,
MP/Jb

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medical

�DP- A.

W?

3-21-su
Pew Two

with the state service.

meow,

we have our om residency
a
from
theirs. An active part of
is separate
training prom
our prom is teaching of psychotherapy. M meters of the staff
ﬁve wotly seminars in psydnotknmpy techniques and there is one
continmus case. In additim. our residents work in the out-patient
depertmnttwohour‘sadeythmughmttmirttmyeerpmgmm. In
that unit. the director and three omenltmts are excellent psychotherapists, and they supervise the residents- both individually, at
which:

As

leeetomhwraweek, mdingxoupsessims, at least

Wm

twohonmes

week.
, the Psyohoenalatic Famdetim of St. Louis gives
e series of seminars two evenings a week fornine months. These
numbers are attended by all the residents of the city. Two of the
«ﬁnalists are mutants in the outnpetient department and give
seminars within our institution in additim. If I add up the number
of tours given to psychotherapy per week, each resident has a minim
of four hours direct supervision and an additional three hours of
lemme and sesimr. Somtimes I think we talk our residents to

mth!
I

sorry to need about the court injmction because such legal
movers. even when necessary, do little to clarify the issues
involved.
was

internship program is devoted largely to giving yang
psychologists who have mapleted their ILA. , a year's experience in
psyomlogioel testing, oomseling, and observation and participation
in group behavior. We have few such interns and they generally go
on to tie miversi‘q for their doctoral training. The psycholow
training program at Washingtm University is focused largely on
developing university teachers . community oriented psychologists who
became active in studies of urban renewal, inmatrisl applications,

Our psychology

etc.
sity)

from Washington lhivereity (or St. Louis mivsrWtes
go into the active practice of psychotherapy. Indeed, the

Few

ml

in the city is that wyohotherspy is a part of
medical practice we mile there are a few clinical psychologists
in practice, their numbers are few and their status relatively law.
You my surely look forum to seeing us in Great Neel: this sumr.
We have been inundated by the bmchures of the Fair, and finally the
ohilorm haw joined forces to insist that even if we do not attend ,.
they must attend the Fair. I believe that we will send them and
Martha to Wt Neck for a major part of July. It is our emectatim
that during the first week of August. Jonathan, mm and I will
leave for Israel and then Europe, and the girls will stay with my
attituc’te

mtl‘ar.

look forwardto
Itwesapleesum dwttingwithyoutﬁsway,endl
0m." best regards to Jean and the girls.

visiting with ym this smear.

Sincerely yours .

MF/jb

Mex

Pink M.D.

Director,

�</text>
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                    <text>February 8. 1965

Br. Abraham 8. Lenener. 11.».
Sussex load

ll

university

Gardens

Great Beck. Long Island
Dear Aha:

It was kind of you to send as the brothers "Psychiatric Education for Physicians,” whioh has all the hallmarks of your elegant
style. I read this carefully. and find that your progran exceeds
that which is available in St. Louis, and indeed is an excellent
progree tor resident training. the hediosl School at Washington
University is preoeoupied with its training programs and intensive
research interests. The new cheirean at 8t. Louis University. however. has launched a small progrse in cos-unity payohietrio education.
and I look forward to his project increasing in strength.
Martha has completed another sessater towards her degree and
will have ooupleted her studies. She has enjoyed it
very such. The children are fine. and we are now planning our

by Kay she

new stationery you will know that this
integral part of the University of Missouri
School of ﬂadioine. with the laboratories and vsrds operating
sucoesefully, I have returned to the laboratory ayoelf. and now
devote the @ejor portion of sy ties to my research interests.
During the past few months I here had the opportunity to teach at
Washington University, and found the students enthusiastic. bright.

son-er holidays. Pro- this

Institute is

now an

and the whole experience a

stiauleting one.

I plan to

come to new York for the APA and hope we can get
Our best regards to Jean and the girls.
then.
together

Sincerely yours,
Me: Pink, H.D.

urzja

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="107092">
                    <text>October 30, 1986
Bernard Let-er, M.D.

Jerusalem Mental Health Center
PO Box 140

Jerusalem, Israel
"

.1

(u-Biubv‘éi-sié

.

Deer Bent,

,

We would be pleased to have Baruch Staph-a visit with us on December 5.

Stony Brook h rather far out on Long Island and it would be difficult to get
here by train from Queens by 8:30 a.m., in time to work with us in the treatment
room. There are other options. When he arrives in New York, have him call me at
my offlee in the morning (516- 444 2929) or at my home in the late afternoon or
evening (518- 862 6651). If there is a problem in reaching me, he should eat my
secretary to call Larry Greenberg, my woclate, and he will be able to make the
arrangements. It would be preferable for him to come out Thursday evening, if that
is possible, and join us for dinner.
Have a good trip to the 0.8. My best regards.

Sincerely yours,

Professor of Psychiatry

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK
SCHOOL OF MEDICINE - DEPARTMENT OF PSYCHIATRY

November 27, 1989

Prof. Bernard Lerer

Yaacov Herzog Center
Ezrath Nashim
P.O. Box 140

for Brain

&amp;

P.O. BOX 457
ST. JAMES, N. Y. H780
P“0"”315W444-29l8

Psychiatry Research

Jerusalem, Israel
Dear Beni,

Congratulations on your successful endeavors to
a research center in Israel. The announcement
which I received today carried two messages -- that Ezrath
Nashim has a new research facility (an NMR or PETT scanner?)
and that you are the new chairman of Psychiatry at Hebrew
University.
The second is a real coup, considering the
perception that psychiatry at Hadassah has been social
psychiatry.
Good luck in your new ventures. I thank you for the

establish

announcement.

THERAPY

If

think that a paragraph or two in CONVULSIVE
describing your program in ECT research would be
you

helpful, send it on.
My best to Ziona,

who

must be

especially proud.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>June 18, 1979

TD:

Carl Letson, Program Aide
Assembly Whys and Means Committee
Capitol

The

'

Albany, N.Y.
FROM:

122148

Fink, M.D.
Professor of Psychiatry
School of Medicine

Max

‘

at Stony Brook
Island, N.Y. llT9h

S.U.N.Y.

Long
SUBJECT:

Assembly

Article

Bill

3h.

The proposed law

7237: proposed amendment

to Mental

Hygiene Law

ignores present procedures which already provide

that psychiatric treatments only be given after proper consent has been
obtained. The law ignores the experience that when the restrictions on

medical practice are increased, treatments are no longer given and
patients are deprived of the best (most effective and safe) treatment
for their care. The preposed amendment will serve to further deprive
patients in state mental facilities of the type of care which may he
most effective. As an example, we found that less than 1% of patients
admitted in 1975-1976 to state facilities received ECT, while 5.2% of
patients admitted to University hospitals received this treatment (Annie,
Fink and Saferstein, 1978).
This

is particularly true for

patien€;who have the following

diagnoses: psychotic depression. involutionsl depression, depression in
the elderly, endogenous depression, depression with delusions; as well
as some patients with mania and catatonia. It is for such illnesses that
ECT is particularly effective, with efficacy rates that are greater than
other available therapies, including drugs (APA Task Force Report, Chapter 2,
8. Pp. 13-56. 1978; Fink, Chapter 3. pp. 21-h1).
The proposed law restricts the sunber of ECT treatments to 15 in
any-12 month period. Such a restriction ignores variability in response

of subjects, relapse rates, and experience with different illnesses.
While most patients respond with an average of 7-9 treatments, about 10%
require more treatments. About 10% of depressed patients who are not
given maintenance drug therapy

may

relapse within six months.

�Letson

C.

2.

June 18, 1979

risk—benefit analysis of ECT finds it more effective and as
safe (or safer) than antidepressant drug therapy for patients with
A

psychotic depression (Fink, 1978; Pink, Chapter 5, pp. 51-58, 1979).

also believe that present guidelines for consent as described
Task Force (Chapter 7. pp. 132-151, 1978) and Fink (pp. 219-222,
1979) are adequate safeguards. This is particularly true for experimental treatments. which already must meet peer review under existing
by

we

APA

IRB

guidelines.

This proposed law is heincus on many counts - deprives patients
of an effective treatment, increases”the cost of care, increases risk
of suicide and death, as well as impairs confidentiality, consent and
freedom of choice in the doctorupatient relationship. Further. the
history of such laws, as exemplified by the effects of a similar law
in California, is to deprive lower class minority patients (those
'served principally'lthWate mental health services), of a useful treat;ment, while upper class patients, with the same illness ere able to
obtain care in facilities in neighboring states. Such deprivation of
fservicee of our minorities is not an acceptable position for the
y'legislature of the Empire State.

ra'References:
American

ikAsnis,

Psychiatric Association, Task Force Report #1h,

6., Fink,

end
‘h79-h82, 1978.
M.

Saferstein, 8.

Am.

J. Psychiat.

1978.
135:

i

a

h

Fihi;
Fink,
MF:be

M.

”Convulsive Therapy: Theory and Practice.

-‘Nsv_York, 1979.
M.

Campr.

h

Psychiat. 19: 1.18, 1978.

Raven Press

�</text>
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                    <text>e...

/

w”?

73SB~SZSSB

20 Docsmbsr 1973

Dr. Miles Mucousok
Klin. usurofys. Lab.

Sshlgrsnska Sjukhusst
Sjukvnrdofdrvaltuingou l GHtshotg
SWEDEN

Dost Milos:

It

for Hjorth's
I have given your output to Dr. Shapiro and
he has promised to give no s Christmas present of the program.
Should it to running, I will obtain thsso measures in addition
to my usual froqusncy mossurss in my uoxt drug study sud, hopsfully, should have sous information for the ousting in April.
was very kind of you to osnd us the program

analysis of

when

Should

I

come

EEG.

be possihls. I would
it
to Europe in tho

like to visit your laboratory
lsts spring. I shall probably ho

aooompanisd by ono of my daughtsrs, sad
to too sons of tho sights of Swsdsn.

I will use tho occasion

Last month I visited Jiri's laboratory in Basel and was
very impressed with the organisation, squipmsnt, programs, and
enthusiasm of the unit. For the first time since 1966, I beliovs Jiri is hsppy and productive-«although he did complain
that ho was tirsd of studying srgot sud hoped that Ssndoz would

find a

more

stimulating interest.

Voits has assumsd the responsibility of my former labors.
tory with snthusissm and is doing a msguifioont job. He has
‘spporontly convinood the funding authorities to give him additional squipusnt on wall so to out up a lsborstory in Copen—
hsgsn. I set him so busy as I must have boon when I had that
position. Thurs is sousthing about life in New York City that
makes msn run when othsts walk. Hora, in the country. msn walk
and I soon to hsvs plenty of tins to spend with my family. for

'whioh

I

am

most

grateful.

�1

.,

,‘vam v-vyﬁ n-.. -

v

V,

(Nu-um. u.

:

7,. 7'

.57

my

.. v

a

‘.

.,

..,

~.w.~...m_w y._l.,mr,. *vna” I

.7,

W,“ VY

V..-"

.W‘W...1v” . ..

‘

u— ..W V..\.,..

my-“ .. “wt, , _W.,.‘f.,_\-.m.

u

m

W"

bi. Milos

Matousek

mmwnwnqmw-v

Again,

my

20

—2-

December 1973

thanks for sending me the programs, and I hope
some outputs to show you in the spring.

that I will have
My

best regards for

a healthy and happy 1974.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>ﬁovember 20, 1967

3r. Jernme Lev1ne

Psychopharmacology Research Branch
3133

Sethesda, 3ary1and

Sear

Jerry,

Dr. Freedman has suggested that we look at tetrahydro»
cannab1n01 with our EEG programs. As I indicated ear11er this
year, we wou1d be pIeased to do so when supplies are availabTe.
,

I have aIready f11ed an application witx Mr. G1ardono for
narcatic stamp 31th special permiss1on for mar1juana, and am
writing to ﬁrs. 3art1n and 133911 for permission to use the1r
pharmac01ag1c éata.
a

'

;

1

be

I am

f1led.

requast the necessary I33 forms
obtain these frcm your cff1ce?

wr1t1ng to
Can I

wh1ch must

take th1s apportun1ty to congratuIate ycu on your
For those of us 1nterested in the b1c1og1ca1 aspects
of psych1atry, the programs of the Psychopharmacology Research
3ragc? have prov1ded much of the leadership of the past decade.
Hay I

appointment.

Goo

uck!

Sincerely yours,'
33x Fink,

3.0.

Professor cf Psychiatry

3szp

�</text>
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                    <text>.

.wmwnvmvw

5.1-.-

‘

4,

I, 3,” ‘ 110'?” ., u.” ”Lyman",

thrﬂmmg

.grn-u..r,.r.‘..., W 1. "a“... 7..“ Hymn—mu

W.v.‘gmn

L-w-r;r'n:waw,-‘~yh.w

ww-

,

.

,

_

wu.‘

v

"Hunt-IT;

December 28. l967
Dr. Jerome Levine
Psychophanmacology Research Branch

NIHH

Bethesda, Maryland
Dear

Jerry,
I

very much enjoyed our discussion of our

in San Juan.

common

problems

On my return to New York, I received a letter from the
Bureau of Narcotics suggesting that the marijuana license which
I requested would be forthcoming, just as soon as I complied

with the regulations of

New

York

State.

The

letter indicated

had to obtain approval by State authorities for such
that
research. Being a good citizen, I have complied with this re—
quest and have written for information regarding the necessary
procedure to be followed.
I now

recently completed a chapter for a volume on the
treatment of narcotic addiction and I am taking the liberty of
enclosing this report for your information.
He

have

Hay I

Healthy

take this opportunity to wish you

New

Year.

1'

_‘_.

gun“;

..

A
'

-wm~

a most Manny and

—-vv,—,.n,v:,-

Sincerely yours,

'Y-rv‘:7—,-z

'vu

‘5.
1:"
ZWM’F-‘W

Fink, M.D.
Professor of Psychiatry

Max
«.wn‘raﬂ'v‘

..

«1—,

MFtkp

«v:-

.,~—.wr

.

Way-1,...

mﬂf'r‘)

:wqunvw;

2W'vr'II—Il

~Mqr

-u

EHC.

-.{,_f-.:

�</text>
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armarn

‘r‘r‘

”WW-u-

man-r

"qr-(mum

:w

W

-,.w

"Irw-o-m—wmmmmv

r

January l9, l968
Dr. Jerome Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Uisconsin
Chevy Chase, Maryland
Dear

Jerry,

Enclosed are two cepies of the report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."
my coworkers and l are saddened by our
additional supplies of this compound.
obtain
to
inability
To us, further studies are important as the therapeutic
potential of this compound appears extremely high. we
would appreciate any efforts that you can make to obtain
the cooperation of Endo Laboratories in further production
of this compound.

As

you know,

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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Karly—71"!”

,

.77.

Harem-www-

January 8, l968

raw,m&lt;~A-w~‘-‘v'

.

0r. Jerome Levine. Chief,
Barlow Building

PR8

5454 Wisconsin Avenue
Room lGCOl

Chevy Chase, Maryland

Dear Dr. Levine:

RE:

I am writing with regard to rebudgeting
(EEG and Human Psychopharmacology).

MH-l3358‘0l our

account 4l-382-l

MH-l3358-0l and ~02

In reviewing the expenditures for 1967 there are $5500 in
unexpended funds which may be carried over into l968. A revised
25-90~l (Section III) is enclosed. THIS XS UhAUDITED AND COMES
FROM MY RECORDS ONLY.

This sum should be used to reduce the award of Mh-lBSSB-OZ.
We

be aware

also reviewed the request budget for l968. You may
that HH-l3003—02. a grant to complete studies at the

have

University of Missouri runs concurrently from 9/1/67 through
8/l/68. Except for some consultation and travel items, it has
not been necessary to utilize this budget and $9,000 remains.
This will be used during the first few months of l968 and it is
suggested that MH«l3358~02 be reduced in this amount.

revised request budget for the ~02 year is attached. The
sums carried forward and the balance of MH-l3003 will be used to
reduce the personnel item.
A

These modifications in the l968 budget meet with the approval
of the executive administrator of the Department of Psychiatry and
the Vice President. both of whose signatures appear below.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max
APPROVED:

B. §chwartz
l.Executive
Administrator

Department of Psychiatry

“FL Haydn Morgan. Vice

President

Research Administration

�</text>
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                    <text>—

aw.

m

‘.

,.,,

a,
.q.

4,7,.

7-5,.»

5

“Armor

1-.

avvm.»1wFM-W

.;

mc?’

van-1

8, 1968

May

A
~r

v.1:

.
Fin

Dr. Jerome Levine
1‘1;aqm’,¢wilﬁfi

KW“

15.1”,

Psychopharmacology Research Branch

National Institute of Mental Health
susu Wisconsin

Chevy Chase, Maryland

:Tz'Wn‘WW‘

1‘

i“

Dear Dr. Levine:

I

ﬁrm":

"~
.

w

.‘ﬁ.

Q'M‘E-w

&lt;.
"Ir/z.“

”AMA”;

”tartar-

am

writing with regard to MHl3358-02 and the

deletion of foreign travel. The date of issue of
the actual grant award was “/19/68, although the
project period was 1/1/68 through 12/31/68. You
may recall that I had inquired as to the delay in

receiving this renewal award letter because it
seemed necessary to visit the University of Istanbul
during the month of February to provide the data for
presentation at the 1968 meeting of the CINP.
Based on our understanding that the revised
budget request had been approved by the Council,
the Chairman of the Department approved this foreign
travel. The total cost was $779.05.
I would like your assistance in having the
approved budget for HH—13358 revised to include
this sum ($779.05) for foreign travel in 1968.
No additional foreign travel has been or will be
undertaken under this grant.
Thank you for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFikp

cc:

Mr. Schwartz

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                    <text>April 10. 1968
Dr. Jerome Levine, Chief
Psychopharmecology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear

Jerry.

I have obtained a tax stamp for marijuana studies from
the Federal Bureau of Narcotics. and am proceeding with the

F.D.A. and with Dr. Roger Meyer.

The F.D.A. has requested a letter of authorization to
pennit them to refer to your data on file (see letter enclosed).
Copies of the letters from Drs. hartin and Isbell pennitting
use of their IND are enclosed.

copy of the proposed protocol is enclosed for your
information. To provide the clinical personnel specially
required for this study, we are submitting a “contract“ request
to Dr. Roger Meyer, following suggestions received by Dr. Freedman.
A

we will be able to initiate the study in mid-May if we
receive approval from the appropriate College committees and
supplies from NIMH. For thirty trials with THC~A»1 at 300y/kg

(20 mg/dose) we will need up to 600 mg. Can this be made
from your office? Is marijuana “leaf“ available
from your office or should I call the local office of the
Federal Bureau of Hercotics?

available

'

will call your office as soon as
Thank you for your guidance.
I

I

receive approval here.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp '_

�</text>
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                    <text>”WWW.

"u"

r-n.

v

June 28, 1968
Dr. Jerome Levine
Peychophermecology Research Branch
National Institute: of Mental Health
5454 Wisconsin Avenue
Chevy Cheee,‘Merylend
Deer

Jerry,

Enclosed are two reports describing the EEG profiles
of psychotropic drugs which have recently been completed

with the support of MH-lSOOB and 13358. These are being
considered for publication by Dan Efron in the proceedings
of the ACNP. 1967.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex
MF;kp

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                    <text>June 25. 1968
Dr. Jerome Levine

Psychopherueoology Research Branch

National Institute of Mental Health
5454 Wﬂeconein Avenue
Chevy Chase. Herylend

Deer

Jerry.

With your assistance. we have received an
Inn (4724) for the etudy of marijuana end marijuana

extracts.

Bncloeed is e copy of the FDA approval.
study progren has been accepted by the Ineeeroh
committee of the college and by the counieeioner of
Hoepitele of the city of New York. we also have e
tux stump from the Internal Revenue Service indicating
our interest in studios at marijuana.

Our

If this completes the ueuel administrative
etepe. we would be grateful for e supply of
tetrehydrocennebinol. Following the suggested
doeege of 20 mg per experiment. e supply of 600 no
would permit no to make a reasonable eetinate of
the neuroohyeiologicel profile.
Thank you very much

guidance.

for your cooperetion

end

Sincerely youre.

7—,.

~&lt;

Pink. N.D.
Profeeeor of Psychiatry

Hex

ﬂPﬂtp

�</text>
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                    <text>June 21. 1968
Dr. Jerome Levine

Peychophernecology Research Branch
National Institutes of Mental Health
5454 Wieconein
Chevy Chase, Maryland

Deer

Jerry.

is

draft

copy of a pharmacological
undertaken
by Dr. Richard White
study of cyclezocine
and
supported by
of the university of Tennessee

Enclosed

a

Dr. White found thet cyclezocine we:
indeed like imipreminc in its pharmacological profile
and I em planned that the reunite parallel our clinical

HH~12567.

experiences.

Many Ebenke

for the support of van in this study.
Sincerely yours,
Hex

Fink. n.D.

-

Protease: of Psychiatry

MFskp

enclosure

�</text>
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                    <text>August

l9,

1968

Dr. Jerome Levine

Psychopharmacology Research Branch

national Institute of dental Health
5454 Wisconsin

Chevy Chase, Maryland

Dear
on

Jerry,

draft copies of recently completed reports
the antidepressant qualities of cyclazocine. were it not
Enclosed are

for the neurophysioloqic data I would hesitate to report such
uncontrolled studies. Perhaps the studies now in progress may
confirm the View and lend some additional Inpport for the EEGbehavioral association model.
for the THC. He will begin the
I am also pleased to tell you
and the clinical studies are
in
naloxone
supply
is again
that
many thanks
summer recess.

Incidentally,

study after the

again in progress.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>October 28, l968

J. Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Hisconsin
Chevy Chase, Maryland

Dr.

RE:

Dear Dr. Levine:
During

this year

we

have

MH-l33§8~02

carried out nuaorous trials

of drugs in volunteer subjects whom no have paid a fee of
$l0 - $20 each session. The amount allocated for l968,
$1,000 is now expanded. and I am writing to request transfer
of $600 from Parsonnol or Consultation to Out~patient Costs.
This is an internal transfer and will not effect the total
amount of the grant.
This request is approved by the appropriate official of
the College - the Vice President for Government Relations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

Approved by:

Mr. F. hayden Morgan

Vice Prosident for
Government Relations

�</text>
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                    <text>1

v

:

4

i

A

...

n..."

co.

~—-

-.

.

c

..

October 21, 1958
Dr. J. Levine
Psychopharmacology Research Branch
hetional Institute of Nentel health
5454 Hisconsin Avenue
Chery Chase, Maryland 20203
Dear

Jerry.
I

believe our discussion was most helpful and have
forms requested to Dr. Salzman.

sent the

my files of optical scan rating forms.
copies of the German collaborative forms and
a note that the programming had, as of May, not yet been
accomplished. Our criticism of their form is the high
density packing and the likelihood that machine reading
will be accomplished with difficulty.

In checking

I found my

Sincerely yours.
Fink. N.D.
Professor of Psychiatry
Mex

MF:kp

�</text>
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                    <text>amv.—

September 30, 1968
Dr. Jerry Livine
PsychOpharmacology Research branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
‘

Dear

Jerry,

Enclosed is a copy of my letter to Carl Salzman, sample
out~puts from our laboratory data scale, samples of our
laboratory data form, and a reprint, as sent to Carl.

to visiting you and your associates on
from Europe to discuss this program.

I look forward

your return
My

best regards.
Sincerely yours,

,0»

.—

.

Fink. n.o.
Professor of Psychiatry

Max

2A

-

A

,-

p-‘M"l',l""

MF:kp

.

w

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                    <text>March

l7,

1969

Dr. Jerome Levine

Psychopharmacology Research Branch
National Institute of Mental Health
_5454 Wisconsin Avenue
Chevy Chase, Maryland
Dear

Jerry,
Thank you

of award of

MH

for your efforts

13358-03 arrived

behalf. The letter
this afternoon.

on our

it

is probable that the delay was occasioned
the administrative practices of this institution. 1
As

have already informed our Dean of the

trust

that the

Your

same problems

difficulties,

will not recur.

assistance iS-appreciated.
Sincerely yours,
Fink, M.B.
Professor of Psychiatry

Max

MF:kp

by

and,

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                    <text>March

l3, l969

Dr. Jerome Levine
Psychophermacoiogy Research Branch
Naflonal lnslifufes of Menfal Heal+h
5454 Wisconsin
Chevy Chase, Maryland
Dear

Jerry,
Our program MHel3358 (Quantifefive

EEG

Sfudles in

Psycho—

pharmacology) is now in ifs Third year. The annual renewal '
date is January i. As of loday we have no? ye? received The

letter for

award

MH~l3358~03.

have checked carefully within our adminlsfrafion and
have been reassured The? we have complied wlfh all fhe
requirements set forlh by lhe adminisfrafors in Washington.
i

am unable +0 utilize The funds in resfrlcfed calegories
wifhouf lhe leffer of award, would be grafefui if one of
your adminlsfralive asslsfanls could look info This for me.
As

i

I

Many

Thanks.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
MF:kp

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                    <text>May

26, l969

Dr. Jerome Levlne

PsychOphermacology Research Branch
NlNH

5454 Wisconsin Ave.

Chevy Chase, Maryland

Dear

Jerry,

Since our discussion of The chlorpromezlne blood levels
and
measures, l have had an opportunlfy +0 discuss #he
proposal shortly wlfh Sam Gershon and at greefer length wllh
Dr. Julius Korein. From befh, I found the expecfaflon The?
the bgggd levels should correlate wlfh The EEG signals. This
Ian ¥9§8$8 unfounded.
8§Bec
EEG

sfudles of biodd levels and some
measure of brain function, and in each fhe correlaflons are
poor. This is usually "explalhéﬁ‘68i°+hﬁlpbaeiﬂdgohefhe
m“'Kb‘l'here have been many

in sﬂﬁdlbs El
barrier'.
if is possible to malnfeln

Héﬁfofhal anasfhesla,
a steady blood level,
EEG
shows specific sequences of changes which
and yet the
are correlafed wllh The subjecf's aneslhellc slefe and nof
with The blood level (raulconealumbsmelzm; 15: 3m, I952).
In a
of cﬂéggdlazepoxlde Whlfmen and Sfern found no
sludé r5981»
ills $5858 WNW antnnahrepol-ted
t8l'l‘8‘t3ﬁ
oﬁhdlllﬁeOEEGtehahgeughel are
laahdc‘l"52¢
'blood—breln
for example,

studyii“6l‘3a‘i‘ll

levels for
with
§¥Bhl8
b18§*
i9 fheﬁﬁlood

+

r

53'”th

a'lenfs receiving bulaperezlne.
$3oT°E§cqeiﬁﬂine, was There a
Phleptadgluﬁcmmdesem mauve

oﬂiég183%.:
mean
W
' EBBMH
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ill-rilllsl'lﬁhg
wwmmgmumsemm
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ne‘lWWWuehmeH-Ipmou
twin
wallow“)

5%
(Ella ggé‘ianl‘ls‘l ko‘ﬁrgiﬁbqe

will

'lrbl’l‘d'lﬂ’llll?

W‘eTLWEEG’WIWW quﬁﬁlum
Wivewmbsmﬂe .EE0 “1993“” Mel-8 bummed

pe ;egzeq on; woe; coLelnpgA'
bee; oxboLgouco ga ena+olusq)‘

suh Loggegoue Mill pgAe so
+pe ebeC4g4goue
pe nulnlellloq §OL pgoloﬂgcg; Legaoua (1;
Qu+gc1bg4e eye;
euq anLegA he can bLOque ¢pe EEC weeanLee'
plooq IGASIQ Ml4u pSpSAIOL suq M1;p o;peL dnou;149;ghe wegenLoe‘
monlq p6 bleeaeq 4o boL4gc1bg4e gu suo+peL a4nqh leg4gua
msA

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3

BL. 16LOW‘3 rel/HUG

—Sa

INS-1A

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�,

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—,,.——....—._'....--y——~-«—..—.—w..-.——v—w.vu“,r»vrﬁ..¢_—w—7.-~..~wlv-—.,_N.V.——w

Dr. Jerome Levlne

-2—

May

“m..- {~__,,,__‘_

w

26, I969

I would be
pleased to parflclpate ln anofher study relating
blood levels wlfh behavlor and wlth other quanflfaflve measures,
and surely we can provlde The EEG measures. l anflclpafe That

expecfatlons

The

may

be

unfulfllled for blologlcal reasons (If

pas? experlence ls susfalned), and any relaflons wlll have *0
be leased out mos?

carefully.

'EEG measures were provlded
W'héWPaﬁlw
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8"! 89‘ Waffle) {JedWEﬁé‘aﬂﬁgﬁl’gédmlhuﬂon
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p
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guq gge wesenLea‘
pghe pgq gu obb0L4nu14A 4o agacnaa ;pe
gluce OﬂL qgacnaegou o; lye cpIOLbLouexlue pgooq |eAela

DL’

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wall

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wvw

—.

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                    <text>August 1, 1969

Ir. Juana

Lavina

Psydloprmnacoloy Research Brand:
Realm
Natimal
of

Imam

mm

susu Wiscomin
Chevy (Jame, Maryland 20203

DearJeny,

Itism

BmloeediaamBCﬂlJmportfw 1968-69.
mivaﬁmmsmtedinJm,sime itpmwidesaview

ofqmproyessaamllasﬁndimctiamwemmwtaldng.

Itmﬂdbetnlpfulformmrwiwmaedatainam

1mm,mshmeyuma¢pwimmtopmvideaﬂxm
basis

fwtluEEGmdﬁmPsycthm(m~13358).

leditbepossibleforymtospendsmtﬁnewimus
ﬁxinsxm,befmthefa11mmdsofmetingasetin? I
willcallyatmofﬂceinafwdays.

Imivedahmﬁmm.3teplm8mmin,mdin

viwofmmlninﬁwECDmpmgrm,Imseminghimacopy
ofﬂxismpwtandwmldb'eplmedtormhimjoinym.

Ilodcforwamtqumvisit.
Sincerely yams ,
Max

m,

M.D.

Professor of Psychiatry

Mszp

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                    <text>w“

V. .~

m my awn-w

“mum-r: w‘».

..

..:-..

vaﬂwm

m.ww|'!l'

“9w“.

AF—mm—w

-mu.

N'w-gmvw—uw‘w-"w' my». .w—v-

—

October 17, 1969
Dr. Jerome Levine

Psychopharmacology Research Branch

National Institutes of ﬁental Health

5454 Wisconsin
Chevy Chase, Maryland
Dear

Jerry,

Following our discussions, I am writing to request
a change in the grant period as well as allocations for the
project Mﬂ-15358-03 "EEG and Human Psychopharmacology”.
We are requesting a change of the
present grant
period to 3/31/70.
.

utilize the funds in some of the restricted categories,
like to request the reallocation of available funds
as listed on the attached page dated October 25, 1969.
To
I would

Separately, we will be submitting the forms for the
continuation year, MH-13358—04, effective April 1, 1970.
Sincorely yours,
Fink, M.D.
Professor of Psychiatry

Max
NF : kp

BY:

(Mrs.) Lorraine Laskor
Director
Research Administration

�</text>
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                    <text>September 29, 1969
Dr. Jerome Levine
Psychopharmacology Research Branch
National Institutes of Mental Health
Sash Wisconsin
Chevy Chase, Maryland
Dear Dr. Levine:

RE:

MH—13358-03

With reference to MH~13358~03, may we request
the reallocation of $2,000 from "Personnel" to the
category of "Outpatient Costs". As we described to
you during your recent visit, we are increasing the
number of volunteers receiving drugs in our EEG
study program. This will increase the allocation
for outpatient costs to $5,000 and reduce personnel
to $132,060.
Thank you for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

BY:

(Mrs.) Lorraine Lasker

Director

Research Administration

Mszp

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                    <text>May

21, 1970

Dr. Jerome Levine
Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Chevy Chase , Maryland

Ref:

101
(MI-i

13353-04
13172-01)

Dear Dr. Levine:

writing to request a re—allocation of the funds
to allow the purchase of the IBM 1800
now
on
a rental basis at this center. This request
system,
requires no additional funds from NIMH end will make
this facility available for continued EEG analyses in

of

I

MH

am

13358-04

psychopharmacology at the annual cost of maintenance.

Specifically, we request the transfer of $71,000 from
the category ”Other” to ”Equipment,” thus reducing "Other”
to $10,000 and increasing "Equipment" to $77,500.
This total purchase price of our system, based
credits for rental is $136,945.

on

the

additional funds are available from NH 18172,
allocated fer equipment to process
the studies of the neurophysiology of cannabis. Purchase of
the 1800 will permit the analyses of the cannabis data
for a $3000 annual maintenance charge.
The

where $48,000 has been

�-

2

-

balance of $12,000 is available in funds of the
Department of Psychiatry and their allocation to this
project are approved by the Chairman, Dr. Alfred M. Freedman.
The

This proposal will make the equipment available to
these study processes beyond the period of MH-l3358. In
the event that these programs are discontinued the equipment

will

be

available to

NIMH

for other scientific applications.

discussed with you, we have carefully assessed
other instruments, notably the PUP-12 and PUP-15 which are
being recommended in similar studies; and while the initial
outlay is slightly less than the IBM 1800, the expense of
re-programming and the interruption in ongoing programs
make the approach to continued work less attractive.
As I

present rental cost is $4330/month. We are
predicating this request on an expeditious approval of
the transfer of funds, effective June 1, 1970 or July 1,
at the latest.
Our

Many

1970

thanks for your considerationaand patiente.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

cc: Dr. Robert Petersen

Chief, Ctr. for Studies
Narcotic &amp; Drug Abuse

ARPROVED:

Alfred M. Freedman, M.D.
Professor &amp; Chairman
mf/

Lorraine Lasker

Direcoor, Research Administration

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                    <text>October 5, 1970
'7‘7‘01‘a'

mu-‘mn‘r-u-vrv—r

Dr. Jerome Levine
PsychOpharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

V'V'I‘w-o

Dear
-r—wvww7ww

-

z

,&gt;

2..

.7.

-.

Jerry,

For the past half year, we have been pre—occupied with our
assessments in a variety of studies, each designed to define
useful techniques. Preprints are enclosed, as these studies have
not yet been published, and will serve to describe the state of
our art.
EEG

wm-,-,.

.,...,,..,,.,

5-0-

w.
s

For two studies, comparable data from other investigators
are now available. Pfeiffer and Goldstein assessed S 421548 in
volunteers using their amplitude integration techniques; and
Dement and Kales each evaluated GP 41299 in separate sleep studies.
If these may be useful to you, I will send you cepies.
thanks for your patients and
techniques of drug classification.
Again,

my

interest in the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
011C.

EEG

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»

-

&lt;1“

—,.

leﬂrpﬂymm-‘Ww

T

February 10, 1971
-

""371"

imv‘vr-rm’ml‘

g
gurkn’

Dr. Jerome Levine

Psychopharmacology Research Branch

National Institute of Mental Health
5454
Wisconsin

Chevy Chase, Maryland 20015

Dear

Jerry,

..—r

RE:

MH~13358~05

,-,~—.

&lt;.
’"'

ﬁi'n'rmvr‘wwmwﬂ'!‘

In the event that MH—13358~05 is funded effective
1,
at an annual rate of $60,000, I would request the June
following
reallocations of direct costs to maximize the use of our
facility.
Personnel
$39,700
1971,

Consultant
500
Supplies (incl. electronics)5,800
Travel
2,000
Volunteer fees
6,300

Y-«vac

rW'erv-wwz‘

Other

Publications

l"71"W“"’

IBM

.w

t-‘r

pm.

600

6,000

1800 Maintenance
and Insurance
5400

_,5,ut

Many

thanks.
Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

MF:kt

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                    <text>.

vm

, rna-zvua-A-vr'w—s -»

“mp-n

,

”Hutu—,—

waswrvmgvm

.ylw—mrngw-ppam

l-wiwwa‘x"

2w 'a-u'm' uwvvm

"(c-”u;

.

u.

an.“

‘

?:.'v":‘tw".t.r».‘|vJv-Hr...

February 1, 1971
Dr. Jerome Levine
Psychopharnacology Research Branch
National Institute of Hontal Health
5554 Wisconsin
Chevy Chase, Maryland 20015
Dear Dr. Lavina:

RE:

NR-l3358-04

are writing to request an extension of the budget poriod
for 9 months, to 12/31/71, without additional funds.
With our prosent balances, this will permit continuod support of
the principal personnel for an additional two months (to 5/31/71);
and the services necessary to completo the write~up and final
rogorts for the romainder of the budget period (to 12/31/71).
of

we

MH~13358~04

In the event our renewal request

starting data

program.

be made 6/1/71,

is funded.

we

request the

to allow continuity of the ongoing

Sincerely yours,
Fink, M.D.
Professor of Ysychiatry
Max

Principal Investigator

Alfred M. Frocdman, M.D.
Choiraan, Dopartuont of Psychiatry

Mtg. Lorraine Looker
Director, Roaoorch Administration
MP:kt

,‘

-.

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                    <text>twctmv

»

q..«...w.—

4.

'&lt;Iy'w'—-

‘
v
..

a...“

March 26-, 1971
Dr. Jerome Levine

National Institute of Mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear

Jerry,

are pleased to enclose a copy of “Computer Aided Interactive
Psychiatric Diagnosis Programs". The volume contains the logic and
programs in PL~1 (DOS) which are Operational on an IBﬁ 360/40 and
uses the CDC display terminal with digiscribe attachment.
We

There are two diagnostic programs, the BPRS of Overall and
Gotham, and the Diagno~11 of Spitzer and Endicott.
would be pleased to demonstrate these programs, and
the report may be useful.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬁrzkt

trust

“a

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                    <text>E

:5

E

Hitch 8,

E

g
,i
E

r

1971

Dr. Jerome Levine

National Institute of Mental Health

Psychopharmacology Research Branch
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear

Jerry,

ww-«w

year of MH~13358 officially ends March 31, 1971.
February 1, I requested an extension of the budget period.
copy of that letter is enclosed.
The ~04

On
A

I would be most grateful for a reply, as the school's
budgeting procedures preclude expenditures against this grant
after March 31, unless it is officially extended.
Thank you

for your cooperation.
Sincerely yours,
Bax Fink ,

.‘ft

o

Do

Professor of Psychiatry

MF:kt

�</text>
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                  <elementText elementTextId="106262">
                    <text>June 14, 1971
Dr. Jerome Levine

Parklaun Building

5600 Fischers Lane
Rockville, Maryland 20852
Dear
I.

.4...“

.
v,

.

-{wvnvuuw‘rwwn—

E

g

E

Jerry,
In our discussions at the

meetings, you expressed an
compound derived from
EEG
BA 1476, the 1,2-dinethylThe
data
on
tetrahydrocannabinol.
New York Academy of
THC,
was
of
the
analog
presented at
heptyl
Sciences meeting on cannabis, late last month. For further data
you may wish to obtain AD 342332 from the Federal Clearinghouse
on Scientific Information in Virginia.
ECDEU

interest in a potential psychoactive

Separately, one of my associates, Michael Taylor has filed
a grant application (Lactate Precipitated Anxiety in Psychopharnacology) to continue studies of lactate infusions in the
search for a better method to define anti-anxiety agents.
For some additional data on rating scale methods in the
aged, perhaps Carl would wish to consult Dr. Carl Eisdorfer at
Duke. I met him at a consultation last week and he impressed
me as knowledgeable about the problem.
Have a

successful

trip to Split.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 7, 1971

3r. Jerome Levine

PsychOphermacology Research Branch

national Institute ﬁentel Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Jerry;

Your suggestion that we hold A ”working session“ on
the subject of quantitative EEG and psychophermecology is excellent,
and I will prepare as detailed a presentation as may make the
discussion most useful. In thinking about participants, I had e
number of suggestions.
From psychopharnacology

I believe Jonathan 0. Cole should

be present, since his interest and enthusiasm has sustained
program since its inception.

this

For a formal knowledge of EEG and drugs, Peter Kelleuey
of Houston, Robert Ellington, and George Ulett are highly qualified
elactroencephelogrepners who arc not now active in drug evaluation.

Turan

Enoch Galloway, Charles
Itil,
active interest in EEG and

have an

Shegess, and Arthur Sugornen

drugs.

general psychiatry, I would suggest Seymour Katy,
Jool Elkes, aorton Raiser, and Denial Freedman be

From

Al Silvoruan,

considered. none have e formal knowledge of our work, but their
roles as ”generaliets" ia well defined. I anticipate they would
be Both interested and contribute to the review.

From clinical psychophamcology, Prita Freyhan, Heinz
and
Leo Rollieter ere activo clinicana who have a broad
Lehmann,
interact and experience. Leo has had e special interest in EEG
and has consistently failed to find the correlations we have re~

ported.

�Dr. Jerome Lorine

Decaubor 7, 1971

Along the statistically sophisticated with a special
knowledge of the problems of reducing large scale data, you may
considar Allan Miraky (Boston). Ron donate, Dean Clyde, John Overhas had a special interest in EEGall, or San Sutton. Kiraky
knowa
bchavior ralationa, he
our work, and is an intoreated critic.

thin type of work, Abraham Hinkler
should be considered. It was his 1952 theory that set no on thin
study route. Since then, he haa criticized my data, noting that
we "ovar—aiuplify" a vary complex subject. He has not dedicated
as Inch time to quantification as 1:11 and I, and in 1966 he participated in tho anticholinergic drug symposium with much enthuFinally. the

aiaam.

“daan” of

‘

I look forward to this session with great interest.
Sincerely yours,

m:

Fink, 3.2).

Professor of Psychiatry

Hing

�</text>
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                    <text>,,._,,~_ 7....‘l‘n.._....,..v

V

.

.

,

,

,

w,

.

,

...

t

..‘t

...

.

..

..

...

January 15, 1972
‘—

»:u

n,

-

Jerome Levine, H.D.

Chief, Psychopharmacology Research Branch
National Institute of Mental Health
Rockville, Merylhad

ﬂ-ﬁmv'70‘wﬁ-

....

Dear

Jerry,

have been asked to examine the EEG pragile of
clomacran (SKF 14336), with a View to defining any unique preperties
of the compound. From the availahle data, it appears that the
We

clinical studies are extensive.

would be helpful for me to have an opportunity to
read the summaries of the ECDEU studies of these compounds. Is

It

possible to request such a readwout

it

?

ﬁany thanks.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>fl..-“

_

a- ”a

,

”a

.

..

.

.

_

,.

.___, _.,w___-.. a...

we“. "my.W_n-_m_,.m~__.v~.r..__mr.,__ amm,ww~—w.-—".-.wwwrw_.—n.—wmmmm

.

I
5

June 29, 1972
Jerome Levine, M.D.
Head, Psychopharmacology Research Branch

National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Jerry,
The

are enclosed.

additional copies of the progress report for

MH—13358

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

V

�</text>
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                    <text>94‘; 11"}uu

M

June 22, 1972

Jerome Levine, M.D.

Chief. Psychophareacology Research Branch
National Institute of Mental Health
5600 Fishers Lane
Rockville, ﬁerylend 20852
RE: 'MH

13358

Dear Jerry:
Enclosed is a detailed summary of the studies in the program,
and Human Pégchophadmacoiagy, since January 1, 1971. This
should
provide summaries of the activities since the renewal application
summary. I have also outlined the studies now in progress and the
EEG

anticipated continuations after transfer to

Stony Brook.

There are some funding problems for the coming year. I have
developed a talented and well trained staff. Each is loyal and en—
thusiastic about the program and desires to move with me. What I
an not sble to face is that not all ~~ indeed only a small part of
those working on this program ~ are paid from this grant. The other
budgets remain in New York City. and I find that a realistic budget

to sustain the effort and pay for transfer and renovation is closer
to $90,000 for the first year
or until each a time as I can assign
their services, in part, to other programs. (Part of the delay in
sending this summary is based on my attempts to obtain additional
funding for this transfer).
——

Nevertheless, I believe I can sustain the program and I enclose
for the transfer year for $60,000.

on pages 20-22, a budget

�June 22, 1972

Jerome Levine, H.D.

I have also added eoee coenente for the continuing years of
to write, for I
the program. These latter were the moot difficult
ECDEU
supeort for this
believe that I should anticipate closure of
of the reviewers
comments
program, reflecting my perception of the
sustained this
have
period. I
for the continuetiou for this project
1960.
ECDEU
since
It is tire to
effort for PR3 since 1957 and for
in not
selfish
sometimes
I feel
summarize what we have leerned ~~
should
and
closure
hove
learned,
having ehered the details of whet we
provide the impetus.
however, the program is to go forward after three years,
197‘.
the decision should be anticipated in 1973 or the first helfendof that
consideration
There are two suggestions-which deserve your
the
of the Peychopharmecology Coumittee. It may be useful to have work—
a
end
convene
to
academic review you suggested in ﬂexico City;
of this diegrowth
the
in
who
have
participated
of
scientists
shop
relevant
to clin—
cipline. To both, we could address the questions
for
your pro~
ical psychopharmacology and provide additional inputs

If,

grommatic

decision.

Should

Stan Yolles

it
has

program to Stony Brook,
by the Inter—
administered
be
the grant

be pooaible to

agreed that

transfer the

Box 269,
national Association for 9eychiatric hesearch, Inc. (P.0.
is
possible
We
urge this, because it
Great Neck, new York 11022).
from
that Association if they administer
additional
support
obtain
to
the project.
I am most grateful for your support and interest these many
continue
years, and truat that your faith, and that of Jon Cole, will
to be rewarded by the results of these efforts.
Sincerely yours,

ﬂax Fink,

e'ieDe

Frofessor of Psychiatry

Hing

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                    <text>say a,

1972

Re:

13358-06

Jerome Levine, M.D.

Psychopharmacology Research Branch

Eational Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852

NH

Dear Dr. Levine,
.vw._..p

tW‘f—‘r‘v-

,
.

wvtr—UU)Y.".RJ

I have been invited to join the faculty of the State
University at Stony Brook, and I am writing to request transfer of the
program, EEG and Human Psychopharmacology, HE 13353—06, and the
equipment purchased under that program, on October 1, 1972 to a new

institution.

This transfer has the approval of the Chairman of the
Deg:rtment of Psychiatry of the New York Hedical College.
r."

'N.’:,

n

m

.1

list

of the equipment to he transferred is attached.
the
part, this equipment was purchased with funds of grants from
MB
18172
and
under
Abuse,
Drug
Division of Narcotic Addiction
project
(Dr. Robert Petersen, Project officer). This project terminated April
30, 1972. Insofar as this study may continue, and in support of the
study, Opiate Effects on Brain Function and Behavior, ME 19476 which
will remain at the New York Medical College, we will continue to carry
out the data analyses at the new facility. With this assurance, Dr.
Petersen has indicated that he will agree to the transfer of the
In

A

equipment.

w

wr'w‘lx‘n‘nlfr

from)

vwv

«-

-r-

nyvsr-u'l-z

rim"

Tr

uw'rn-

,...

.
u.

‘e‘hhmwlmm‘

«mer'.

-.

n

"mm.

mumn

Hr

have arranged for my continued participation in the
programs of the Department of Psychiatry of the New York Medical
College for a minimum period of one year to allow an orderly transition.
This will allow for the transfer of responsibilities of those employees,
now working on NH 13358, to other ongoing programs.
We

have received an estimate of $16,250 for preparation of
the site at the State University at Stony Brook tp carry out both the
recording and analytic parts of this program. The space assigned by

I

the University is adequate to the needs of the program. In developing
a budget for the period beginning October 1, 1972, I shall request
permission to transfer this amount from the existing categories to
that of "renovation"; and an additional amount for 'moving of equipment".

�As

evidence of the agreement of the College to this

transfer, I have asked both

Dr. Freedman and the appropriate

the College to sign this request.
-\~

-.

a—vw—

var—u-w

~
«

&lt;W“"vw~'

I would appreciate your guidance
should take to make this transfer orderly and
with the studies. My thanks, once again, for
your associates have given this program these

assistance in this transfer.

officer of

as to the next steps we
with minimal interference

the support which you and

many

years,

and

for your

v—"Y'

n...

-

Sincerely yours,
imam"...

”WW—.1“...

Max

u—nrnv

~u;;~v’w_&lt;....~._

wvv-...,...-.,...&lt;‘

Alfred M. Freedman, M.D.
Professor &amp; Chairman

,.-.—u~\

..
»-.

n.

Lorraine Lasker

Director, Research Administration

my“.

u.
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m

W

run-v

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mummy

WWHWIKJ

er
-r

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«M'Wrm'

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-

Fink, M.D.

Professor of Psychiatry

w.-.w——,

mf/

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q,"-.-—.w,

A

...-_—..w..»w ,r. “H,

m

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-

Equipment Purchased by New York Medical College under the following
grant programs: ME 13358, 18172; and College funds 46-122-1

:.-—-—m~—wu

Items to be transferred:
"m

wt.

.

IBM

4-

including 1801, 1442, 1443, 1810, 1851, 1856;
book
card files;
cases; table; disk storage and supplementary
disks; tape storage and tapes; analog tapes (excluding
those to be used by Dr. Volavka)

1800 computer complex,

Hewlett Packard oscillators
1/2" tape recorder
Krohnheit filter
EEG polygraph
Ampex

£~P'P‘H'P‘k‘hJ

EEG

coucy

Tektronix oscilloscoPe
armless chairs
executive desk

secretarial desk
chairs

Nwww-L‘HH

drawer files
bookcases
5

sets shelving
large cabinets

selectric typewriter
Friden calculator
13M

h‘h‘k‘

3x4

n.
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.

.r‘

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I"

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2’
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the”

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projector

. ,.

_.

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V

_

V

�wn—w

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,

.

m

,

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Equipment purchased by IAPR now

V

Grass polygraph

oscilloscope

oscillator

P‘h‘h‘h‘h‘h‘h‘h‘

Kronheit
HP

filter

tape recorder
tape recorder

Ampex

couch

side table
desks

chairs

PLAN-5N

file cabinets

sets shelving

coay stand

«yum

~q41urlwﬁ'm'nx-Mn—

.'
.

~v

ww‘uv-w-‘rr:

rle‘ﬁ-1‘7

Wra:'r!~lw'wl”!'|'*m‘l”"”

m—r—rwm—uu-qx-

“s?"ll"w~

.zrmw

at

5

East

102

Street, to

be

transferred:

�“area“,

...,—.....7.

w

.»

nu.»

wm_-_,,_mw., 7......

m

__.

mm

Wn

.

w.

yum-n... F.

,.,.‘,...._.,=.7......,,_....,_

w..,~.-,,.,.Vw-nw.m“uni.

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-,

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V

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.

A
-

,
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-

can

"WU-'0'“:

wwzua—n-u—v

'wv'r

--

Equipment purchased under
Remaining at NYMC:

grants, Psychopharmacology Funds,

and IAPR

At Metropolitan Hospital:

All laboratory and office equipment on 15a and 15b including
laboratory on 15a; office furniture 15a, 15b, Psychopharmacology
Clinic; typewriter, dictating machine, tape recorder for EEG and 2
tape recorders for voice; a air conditioners (window units); and
complete clinical laboratory equipment and supplies.
complete

EEG

EEG 4

At

5

channel, oximeter, typewriter: These units are
in use for ECT studies and
will remain. Should these
studies terminate, EEG
may be transferred to other
studies or returned to IAPR.

East 102 Street:

list:

6 offices including
typewriters; l calculator; 2x2
slide projector and screen; refrigerator; safe; storage cabinets;
keypunch; and sufficient analog tapes for work at Metropolitan

See attached

desks, chairs,

Hospital.

files,

bookcases;

remaining are
2

..

a.“

r

.1...

7-. gym-www.7—

�</text>
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q...

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&lt;_,_~—w--v&lt;

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7383-83633
20 December 1973
Leo

Hollieter,

President

M.D.

American College of Neuropaychopharmecology

Veterans Annihietration Hcepital
Palo Alto, California 9&amp;305

Dear Lee:

vriting this letter in regard to the latest meeting
Firat, I vieh to commend.thc Arrangements Comp
mittee with their success in providing ideal weather and a
moat aalubrioue environment for the meeting. I hope the Council
will consider an annual return to Palm Springs with a high pri~
ority.
I

of the

am
ACHP.

I trust the painful ieauc or the invitees has been cue»
ceaetully resolved. I was embarrassed by the Council and the
Secretary, as were some other members of the Coylege, and I
trust this will not recur.
»

I am writing specifically to raise a qucetion with regard
to the arrangements. The registration the of $25.00 was tied
to a dinner and the free distribution of alcohol. Since not
all members of the ACE? drink alcohol, it seems that we are

subventing alcohol users and in some rather indirect way cn~
couraaing alcoholism. As a college dedicated to drugs and
their abuse potential. I believe we should be more sensitive
to the problems of abuse and not be put in the posture (even
it noble and fund~raiaing motives are involved) of encouraging
alcoholism. Alcoholics ought to pay their own way. I would
hope that the Council would make it possible next year for
there to be a separation between an attendance Ice and dinner
and alcohol fees.

more important reason for writing this letter
do with my desire to suggest that the Program Committee
consider a round table or symposium on the effects of poly—

has

Finally, a

to

peptides on brain function. During the past few years, a hunter
of scientists, both in the united Etntea and Europe, hare demonstrated that ACTH and M33 and their derivative peptide chains
may have central effects which are highly specific with regard

-1-

�goo

Hollister,

M.D.

«2*

20 December 197;

to functions of memory and extinction. Scientists working in
this field include Moaongh, Gold, Rustin, dsWied, Small, and

Esooan. my guest ax the ACNP, Dr. Bonk van Biases, in a phar»
mooologdst actively involved in this research program.1n Holland
and wort: closely with Br. David deﬁlod. At my suggestion,
Dr. van Riezun is willing to provide some of the funds neces—
sany to invite the purtioipdtion of scientists for such a sympoa~
inn, should tho ACE? wish to hold such a session and, secondly,
should its own funds be inadequate.

I thank you for the letter regarding the HEW regulations
and tho Eudoral Beggater. I have tent a letter similar to yours
on behalf of tho APPA-a oopy of which in anclosed for your
interest. I will be grateful
you would keep me apprised
of one evaluations of these guidelines 80 that I may be able

if

to present then.to a wasting of the Council and the APPA during
the first week in March. That will be in sufficient time if
the 90~day extension is allowed.
My

of the

best wishes to: the success of your tenure as President
and my best wishes for a hoopy and healthy 197h.

ACE?

Sincerely yours,
Fink, M.D.
Protozoa: of Psychiatry
Mn:

MF/ois

Encl.

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u

vi,—

s,

mmwwrw-qryq

a-m

October 15 , 1979
Jerome Levine, M.D.
Chief, Psychopharmacology Research Branch
NIMH

--

-

Rockville, Maryland 20857
Dear

Jerry,

-Thank.you for the copy of "Coordinating Clinical Trials
in Psychopharmacology", which I was able to read this past week-end.
to the earlier guidelines which have been
It is an excellent addition
and
provides an enViable standard for
issued by the Institute,
it some
of the sponsors of our studies of
notified
have
future trials. I
and
am sure that they will find it
I
of
the
volume,
the publication

useful.

I also want to thank you for the assistance you have given
of Organon. He has accepted the responsibility for
of
guidelines for the clinical trials sponsored by that
developing a set
he
has
and
written
a number of recommendations which clearly
company,
NCDEU
these will be adopted by his masters
believe
I
standards.
meet
well
as world-wide (although they have some
0.8.
the
as
for studies in
in countries where the AMP system
the
with
coordinating
trials
problems
Dr. Hank van Riezen

is standard).

:

Our own

-

-.

.

laboratories continue to assess new drugs in
we have identified three new putative psychoactive

phase I trials, and
3770, is
drugs in the past 18 months which have much promise. One, Org EEG
and

active than mianserin and tields a similar
behavioral profile, promising to be even safer than mianserin in lack
frustrated by
of cardiotoxicity and anticholinergic effects. We have been 1980
studies
the
ACTH
and
that
optimistic
are
fragments,
the studies of
My book on
DGAVP)
he
rewarding.
and
(DTVE
will
tore
of other peptides
BCT (Cbnvulsive Therapy: Theory and Practice) has been well received and
the first reviews were most kind. It also receiVed.0he of the 1979 Anna
Monika Foundation awards, so I am rather pleased.
clearly

much more

Again; thank you for sending the Volume.

My

best regards.

Sincerely‘yours,

'

"‘I-vw-rc

Max

Fink,_M.D.

Professor of Psychiatry

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                    <text>February 10, 1971

Peter

M.

Levine

2520 Monroe

New

Street, Apt.

C

Orleans, Louisiana 70118

Dear Mr. Levine:
Thank you

for your inquiry about

a summer fellowship.
not have the opportunity to support a
fellowahip this year.

I regret that I

do

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>.

rah-rm TH'P-v—V-Ih".--

nun-r

I
‘:

ww‘

u-nw-

'

L

“CW“.

,,,.

.7.

.

‘va

June 9. l970

)1

'x-Mw,

CepT. RoberT Levine
228 Texas Drive
Dyess AFB, Texas 79607
Dear Bob,
lT was a pleasure seeing you in California. l didn'T have
a chance To fly back wiTh Hy Denber so we dldn'T sTop aT Hobbs.

ll

have had an opporTuany To discuss The possibiliTies
of your reTurnlng To New York nexT July and There are Two opporTuanies
which presenT Themselves imediaTely. As you know, The DeparTmenT
is expanding noT only inTo The new menTal healTh cenTer (hopefully
by March) buT we have esTablished a formal relaTionship wlTh
Grasslands and The MonTrose VA. in adlelon, we are sTili negoTiaTlng
e reiaTionshlp wiTh Kirby HospiTal (l/3 ManhaTTan STaTe HosplTal).
This lasT relaTlonship is sTill in The discussion sTage elThough
each monTh I hear opTlmlsTic noises from Al Freedman.
1

and

l

The relaTionship wlTh The MonTrose VA is esTablished and Al
Freedman is Chairman of The Dean's CemmiTTee. They have a few
Thousand paTienTs, plenTy of laboraTory space and a clinical

direcTor
school.

is anxious To accommodaTe research as well as The
have discussed wiTh him The possibiliTy of having

who
i

Two members

of our sTaff appoinTed as clinical invesTigaTors.

believe ThaT These poslTlons can be funded by The VA, and
bring wiTh Them supporTing funds for research, as well as a
research sTaTus which would be mosT producTive for you and Mickey
To conTlnue your sTudles excepT for The obvious handicap of
i

having a small percenTage of female peTienTs.
has much To commend lT for your work.
i

VA

am

enclosing copies of

The

The

VA

populaTion

applicaTlon ouTline for

The

posiTlon as well as a blank i0~2850.

for your reTurn

York I Think you
should apply for This posiTion by compieTinq The form and sending
me a one page sTeTemenT of your fuTure plans and ambiTions and
a proposed research plan (6.09~b~6,7).
3A5

one underpinning

To New

pun-r

�Eyre—merrnw

s,

.

i.

.,

www-

.

WF“ “sun-7w

...._...

,

-~

'--10'

vw~_m_v—.w——

I

Dr. R. Levine

June 9, I970

~2—

in +he evenl Thaf we are successful, your appoinfmenf fo
fhe Deparfmenf of Psychiafry will be ihe principal appoinfmenf.

This appoinfmeni will nof preclude your parficipafion ln sfudles
a? olher
i

affillafed insfliufions.

i would like To recommend lwo of you for These posifions and
have asked Dick and Mickey To fill ouf similar applicaflons if

They wish.
My

besi regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp+
673C.

urn-«w «w»

�</text>
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                    <text>:

t
k

g

E

E

March 29, 1971

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

Stan has gone over yhe data you sent him, and his asked
me to forward the analysis - which is enclosed. He suggests
that the rigorous approach views the data as 3 sets of repeated
measures. Because of the small sample size (most probably) neither
the analysis of variance F nor the means and 5.0 are significant.
If the sample size can be increased, the test should be re*run.
Both he and I made some notations on the interview score
The suggestions are based on the lack of clarity of

sheet.

the item divisions or definitions.
‘Our

best regards.
Sincerely yours,
.1... Fink, 2.4.3.

Professor of Psychiatry

Hszt

�</text>
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                    <text>haw ..,._.....w TE“... .7, he}.

_

W , m1.

.

...-

.

..

"arms-u .twv

we“

guru-rm

.Wz-Wramw qua Na: wu-r- ."r—Fryr-IIWUI':E¥L

,

-

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,-

"’\'&gt;'r—n

.; Kw

-

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u

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newmwxm”.

"WWFN‘M‘-

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i
WW“

TI'D‘CI-I'

.
VJ.-.

Wnimrﬂm

March 25, 1971
Maw

amnmwn-uw

.

nun

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

w&lt;vsw.u~;mm.w~r1

to receive your letter and find that you are so
active. There is a great need for data on the incidence of drug
use, and a sample of 5000 is a good one, although it can be criticized
as too large for the purposes of the study. Ybur solution, to check
every 10th booklet, is probably a good one not only for your reason
of practicality, but the redundancy that will probably result from
such a large sample in a basically homogeneous population (i.e.,
male, AF, 20-30, education above 8th or 10th grade, etc.).

It

1w

-

rm

was good

—

suggestions about the questionnaire. The use of
cut-offs at 18—29, 29:25, g§730, ... provides confusion and
ambiguity. Perhaps it could be clarified. (The study may be of
sufficient interest to NIMH for you to get a small grant for
keypunching and data processing.)
I have

it
1...

...

~.A..K.-m,,..vl

u

w-—IW1'FJ:-——.-.\u~vu-n

qmm

u

m!l-&gt;-'V5)F'"V’.Irv1hlulw-nrw

r
-—-

.&lt;
-

r»

’WJKa-v‘rl'"

some

The data on the Zung

to Stanley.

scale looks satisfactory,

and I

will give

Since last writing, I have assumed responsibility for 2 floors
we have begun some
at Kirby Manhattan Psychiatric Hospital, andNYMC
residents in
supervisions of the staff. There will be 4
4 month rotations beginning July 1, in addition to the Kirby staff.
This provides a nucleus for patient care. We even have some funds
for supervision and consultation, and this is reasonable as a

beginning.

The Methadonization of NYC is increasing rapidly and even
G.P.'s are in the act. Soon, methadone will be recommended for
everyone and the two logical cheap resolutions will be touted:
free methadone from selected local M.D.'s then from alcohol

distribution centers (bars). But, our studies of the antagonists
continue, although we are more actively studying marijuana.

"wn'nu \J"!

a:

.

.._,,

�v»

r

-r:: —\ «a»

2x197-.. Wu”

A

~‘*.W!",v~‘u

&gt;

V

~rv

~u-

m

mjr’sr'U'av-«W

-.-~v-~mm,-vﬂ-‘~-":W' ’WAWM'HJ‘L:qv

Dr. Levine

,

,

,-

~2-

—

'lin-Afn'."w"cram «my

ruﬁre-Tn-m’"

-

..

r :-- w

March 25, 1971

Dick's studies are progressing well. We have established a
consulting relationship with a chemist for his spinal fluids. Mickey
has sent me a protocol for the continuation of the studies of lactate.
any studies you wish to undertake at Kirby? As I
wrote to Mickey, it may be helpful to do some protocol writing now
and suve time later.
Are

there

pass your letter on to Stanley and Dick, and hOpe they
I'll
answer you soon. Will I see you in Weshingtoa in May at the APA

and 38??
Hy

best regards,

and keep up the good work.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.
~..-

-~—u:-—.y

..-

.

Mszpt

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                    <text>T3R*502

January

thh,

1973

Dr. Hubert Levine,
10 Mulberry Lane,
ﬂew Rochelle, R.Y.
Deer Bdb,l

During the past two decades I have had many cowarkere
and students, but no.perioé was as fruitful or as exciting
for me ee'the time when yuu, Miekey Taylor and Dick Abrams
worked so enthusiastically during your residency. I found
your wurk,1n particular. meticulous, thoughtful and inspirea.
Since your return from the.aerv1ce. I have enjoyed your
enthusiasm and.the care with which you have undertaken

studies.

-

It is therefore vith

mush

regret that I anticipate

your leaving the service. I look forward, however, to your
eueeeee in your new position; and trust that you will
continue your enthusiasm and interest far research. I
should like to hear or your progress, and should you need
my collaboration, I should enaoy the Opportunity of working

with you again.
My

very beet regards.
Sincerely yburs,

MEX Fink. MOD.
Professor of Psychiatry

MF/id

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                    <text>agaaaggaga
Angult 11. 1972

1‘0:

Dr. Robert Levine and Dr. Robot: Ronnie}:

PROM:

Dr,

SUBJECT:

ORDERIHG CYCLAZOCIHE FROM KIM}!

ﬂu

Fink

I have filed the necessary

forms

for

an IND

for cyclazocine.

Paragraph 3. indicates that: future supplios are to be

obtaingd from

Mr. Boyer

at

N133.

Paragraph 4, indicated that Dr. Runny, in to recaiva routin-

clinic reports.
Plane contact Hr. Boys: or Dr.
.

of cycluocine.

Ramsay

far additional suppliu

�</text>
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                    <text>January 21, 195“

7‘5.

he Street

Aberdeen, Sootlend
Dear Mr.

I

have

levieom
Thank you very mob

just received.

foryour letterof Deotnber 13, mien

mascara Institute of E’symietry does not have positions
we are fully accredited for the Peydxietrio Reel-u
The latter is athne—year program forwhich
Program.
Training
denw
eligble
would
he
upcm the moletim of a satisfactory internship.
you
Ifyouwishtoheve suchanintemship inSt. Louis, Imuldmeamnd
that you make application to the Citypﬂmpitel. St. tools, mum,
me; has an excellent affiliated program.
The

for intermhip. but

I shmld like you to know that appoixmmnte fer zuiwhoy in
this mtitution require the satisfactory oompletim of the some

eweimrtim.

A

hmetme describing the

monk you

my

mob for yam

9mm is enclosed.

WW.

Sinaemly yams.
Max

m, ”I

Director

Mleg

m.

1

Do

�</text>
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                    <text>January 4, ‘96!
Dr. Louis Levy

Ill Park

New

S?

Haven, Connocflcu?

Dear Law,
O

am

fho notes you

sorry fha? if has Taken
requested. bu? they were

associates in Missouri
nofos are affached.

and

hava

!

me

In

so many uaoks to frack dawn
the hands of one of my

Just received

fham. Your

crigtnal

-

Whtio we aomplefad sfudtes of cyclosertna In psycboflc
paflen?s, the numbor of subjects was 100 small #0 provide a definite
E28 éa?a. Those addi?lonal s+udias «are
report wtfhour adli?tona!
}
£af+ 5+. Lauts and have not been compiefed. if Is
tn progress when
fhe lmprossion of my assactafo (and also msua) #haf cyciosarlnc may ye?
be usefu! In the symptom provecafion fraafmenf of schizophrenia.
Thanks again for fhe oppor+uni+y #0 read +hese nofes.

Sincaroiy yours,
Max

mf/

Fink,

M.D.

�</text>
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                    <text>August .21. 1965

Dr. Lawis L. Levy
2% naming Home Lane
Orange , Cameetimt

Dear law:

I lave recently hem interested again in the compomd
I recollect that many yam ago you were
interested in this coummd. In ctmdcing the literature, I

cycles/wine.

find no publications.
Am

I unmet in recalling that you studied this conpmmd?
grateful for citatim to your work or that

If so, I would be

of your

oo—woﬂcers

My

best mgards.

Sincerely yours,
Max

Fink, Md).

Professor of Psychiatry
Hchp

�</text>
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                    <text>—».—....._—7

WW,-. ‘ -W,WVWW.WMW_W~,—nrwv_w_..—
.

.

.mx—v-Fm’m..-

‘ﬂ—M.m.w—wr

-

September 16, 1965

Dr. lawis
111

New

1..

Levy

Pm Stmet

Haven,

Weticut

Durham
Your

notes

on cycloserfme

We}

are very helpful.

They

indicate

that the
is noumtoxic md it is precisely for this
mason that we would like to make scum observations in our
aovemmntally ill. Idomtthirkﬂmtweneedathardata

at the present time.

IMfomanitoseaingyouatthemtingsinNewYoxk

inDacamber.
My

best mgams.
Sincemly yours.
Max

Fink,

M.D.

Professor of Psychiatry

thp

�</text>
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                    <text>March

4, 1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Bear Lew,

After many years. the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizophrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ants and have no longer continued this
line of work.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

�</text>
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                    <text>March

4.

1970

Dr. Lewis L. Levy
290 Meeting House Lane

Orange. Connecticut
Dear Lew,

After many years, the report on cycloserine has finally
appeared in press. I am pleased to enclose a copy. We found
this application in exacerbating schizoohrenic behavior very

useful.

Since leaving Missouri, I no longer have chronic
schizophrenic pat ents and have no longer continued this
line of work.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

enc.

�</text>
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                    <text>March 5. 1965

Daar Low:
.

&lt;——._~.

.

...-.W..-.—_

_

Thank you for your vonoarfol lattar tron
-— tuck a romantic ulna!
Island
Thursday
It atlnulataa
tho imagination and nakoa thoaa of no living through
Missouri's «iota: draaa of auoh aouthatu ell-ates.

I

writing to aaoh aaabar of tho Board
taatooluc than of tho April 3th looting. Harold
had takao taro of tho taaarvatlona and ha and Gaorga
.

art

am

a proposed agraaoont with the
Unlvaraity of Missouri.
now working on
wa

have oomplotad

tht final financial report:

to: tha Public Hoalth Service for each of the grants
terminating in Decanter and thasa have baan aubolttad.
I antlelpata that thay will aooo instruct on as to
tho disposition of tha balances remaining in cons of
tho funds.
I have toquaatad

an lovootory of

all the

will have this
avatlabla for tho aaatlost I ballava it would ha
propar for tho Foundation to approwa tho ttaoafar of
equipmant bought by the Foundation and

all tho aqulpaant

bought with

grant funds to tha
Univaralty of Hiaaouri. no that the pruoont grants can
continua the accessory maintenance agraaoaota. tapalra
and modifications at thay baton: oaoaaaaty. Theta art
a tow ltaao. mostly of an office aquipoant nature
which tho Foundation haa porohaaod with its own funds,
and I will taoomnand that thaaa ltaoa oootinoa to be
tho property of the Foundation until such tlaa aa thay
ara uaad pradonloaotly by tho unavatalty of Hiaaouri
pataoaool.
USPH

Gaorgo'a program for tho State is not befora
various Lasislatlvo Committaaa and he has told II.
and it has appaarad in tho nauapapara that tho Lagialatorn hawa found llttla to criticize in his program. It
appaara that ha will obtain that: support and 1! anything, ha is hoping that tho Sonata will increase tho
covaroor'a :aooaaandattooa. Ina Eaaoutivo nodgat for
tho Inatitota provtdaa no growth during 1965-66 and
I ballava that ha 1a analoua to aak for additional funds.

�~2-

Hatch 5. 1965

Honour. ha is cautious and has rsqnsstad that vs
taka no action until that is a lots oppottnna tins.
for this mason. I has not oontaotad lit. Langmbars.
It Goons ohansas his aind haters tho stating. I still
manna to out Mr. Lanxanbarg and provida such
support as may in naesssaty. You should know that
{Boot-3a is vary plaasad with tho support that tha
usntai Baalth Association has baan giving bin, and indaad I think, if I intsrprat his oomsnts oomctly
ha is counting on thait support than ha goss to tha
Lauslativa co-ittaas for additional loads.
91:. Kashinsr and Dr. Itil hays taduoad tha
nadioation for Katy so that now abs is moshing no
aotiva dross ampt occasional sadstion. not be

hasiot is insignificantly dittasant from tho patiod

of tins

uhan aha was moshing drugs. Within tha
asst lav wants us will ondastaka a norm: o! spacial
studios. in tha natnta of brain was no languags
tasts. which may ha halpinl to us in tamding
futthar traatnsnt.
Soak up as not: sonshina as you can mat
and us look forward in hating you join no in Aer.
By

hast parsonal ragards.
l,

sinoataly yours .
Has

this
1'. S.

rink.

11.1).

just oallad Harold to ask if he has
nsssaga for you. Ba indicatad that ha had
1 bays

any

ansvsrad you: lattat. sanding it to your bonus
with a nuts to ba forwardad. As ha taoalls its
oontsnts. tho only spatifio nota was that ha
did not think that a ly-Lav handnsnt was naeassay to provida for Board rotation.
14!

�</text>
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                    <text>February 10, 1971
Mrs. Carol Lewin, President

Metropolitan EEG Society
United Hospital
Boston Post Rd.
Port Chester, New York
Dear Mrs. Lewin:

not have a supply of the EEG classification paper
sufficient to make the many copies you requested available.
I am enclosing some copies in the hape that they can be
duplicated where they are most wanted.

I

do

I would be pleased to be a speaker at one of the monthly
meetings, and suggest you call to set up a date.

I

would also commend my associate, Dr. Jan Volavkc to you,
as a speaker. He has an extensive experience and could discuss
a variety of subjects with much merit (369—7900, Ext. 247).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF1kt

enc .

�</text>
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                    <text>October 25th, 1972

urn. Carol Levin,

President.

Mbtroyolitan Electroencephalagraphy Soc1ety.
Mndiaal Science Bu11d1ng.
550 First Ave..

Haw

York

City,

H.Y.

Dear Hrs‘ Levin,

I

must congratulate ycu on your fine work with the
As you may not know, I am moving

Mhtropolitan.EEG Society.
my

laboratory to the.Stata ﬂhiversity of

Bronx and

next year.

will not be in

New

York exaopt

at Etony
at rake intervals

New York

I think that

your suggestion about having a session on
and I would.suggest that you invite
aw aaaaeiate, Dr..Jon Valavka. He did participate in the
syngonium in Hauaton and has extensive experience. not only
with research aspects of drug Share, but with the clinical
as wall. may I suggest you reach him at (212) 369~7900.
drug abuse

is imyortaat,

Best regards.
Binnorolydyunrs.

MB:

fink,

M.D.

Profaasor of Psychiatry
cc. to Dr. Jon Vblevka

Mm:

�</text>
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                    <text>7383—515

February 6th, 1973

mew 8.

K111». $1.1)...

numb (hater;
Becpital,
Roam 8?.th
LY.
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w any unique contributions
been

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contributions
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state.
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would vary much wish

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to do w. I ram-vet
to ski with my family

wanna mung.
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Fink.
m
Professor at Psychiatry
11.13.

149/15

�</text>
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                    <text>April 2,.1968

Ir.

Thomas Lewinson

Research Division

Hoffman-LaRoche

Nutley.

New

Jersey

Dear Mr. Lewinson:
e cony of our latest report. He are encouraged
the discrimination of EEG patterns
continue
to
by this
to
of new drugs
identify their preper clinical applications.

Enclosed
work

is

grateful for copies of the reports
recently written.
I would be

you have

7

Good luck

at the

BIA

Meeting.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

‘

�</text>
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                    <text>Edward Lewis,

MUD

Jt.,

M.D.

Street, a.w.
,

1405 Eye

Washington, 9.0. 20537

near Dr. Lewis,

article in the JAMA is an important contribution
to the clarification of the issues surrounding heroin and the proposed solution of a heroin maintenance dolivary system. In addition
to the cxpcricntial anguments you present so well, we have been
Your recent

impressed with the pharmacologic argumenta which were sufficiently
compelling for us to raconsider cur part in the proposal by the Vera

Institute for‘a heroin delivery project.

-

"facts”

do not know what the truth is about methaﬁone ~ so many
change as they are preaented by different advocates and

-1

critics, but

facts are clear

patient populations requesting
heapital care are sharply reduced (outpatient methadone is satis~«
fying the demand), and the ready availability of methadone at $4—6
for 40 mg ”biscuits" in.ﬂew York City and in Suffolk County.
tWO

Uur own

—

suggestion, should mothsdoae'delivcry continue to

in the public intateat, is to replace it with levomethadyl. Jur
experience is lufficiently favorable, for delivery 3 times a week,
that it is a comprise that the govornmental health agencies are in~
listing on extenoivo additional animal testing so as to delay the
use of lavcunthadyl - which seems more useful than heroin maintenance.
I notgd with intgrcst yon: cautious sentence about the narcotic
antagonists.
be

Again

my

congratulation:

on an important

contribution.

Sincerely yours,

rm Fink, sew;

_

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106622">
                    <text>w: .“11'4nwm‘—'Wn“sm-‘-

7)

.

..

uq-M'wv,
4,,“
..
,

w.

.

.

‘

{

.,

an

M“,

.»

‘1

_

n.“WV

.7

..‘_. ,

v

_

.mem(w

73KY-028

January 23, 1973
Mr. James Lewis
Elmwood Hall
New

York Medical College
New York

Valhalla,

Dear Mr. Lewis,

on

it

is no longer possible to set aside funds fbr TIAA
a tax deferral basis. I would upprecitto your cancelling payments to

TIAA

Since

on my bohnlf,

effective January 1,

1973.

Thank you.

Sincerely yours,
Mn:

Fink,

M.D.

Protector of Psychiatry

v

a,

�</text>
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                    <text>March

1, 1980

Dr. Lawrence J. Lewis, M.D.
Anclote Manor Hospital
Tarpon Springs, Florida

33589

Dear Dr. Lewis,

It was kind of you to send me a copy of the evaluation summary
of the progress of Ms. Judith Parnam. She is qpito ill, and your efforts
on her behalf are interesting and described well. I hope that some progress
witl be achievod.
Thank you

for keeping

me

informod.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

�</text>
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                <text>1981 </text>
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              <elementText elementTextId="63763">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>April 26,

1972

Mark F. Lewis, Ph.D.

Chief. Visual Proceeeee Unit
Aviation Psychology Laboratory,

Civil Aeromedicel Institute

P.O. Box 25082
Oklahoma

AC~118

Oklahoma 73125

City,

Dear Dr. Lewis:

Enclosed is e registration form for Iyeelf and one of my
cadworkers, Dr. Rhee Dornbush. I have aeked Dr. Dornbush to attend
the meeting and we have separately requested a reservation at the
Sheraton Inn on her behalf.
have reviewed the work we would like to present at the
I would ask that you amend the authors to include:
Max Fink, M.D.. Rhee Dornbueh, Ph.ﬂ.. Jen Volevke, K.D., and Alfred
Preednen. M.D.
we

Sympooium and

The

preeentation title should be

amended

to read:

"Acute and Chronic Physiological and Behavioral Effects

of

will

THC

and Herijuane

in Volunteere"

We will propere e manueoript for publication, which hopefully
be reedy at the time of the meeting.
My

secretary has

to Oklahoma City on
15, Flight #664.
Again,

my

TWA.

reservations from LeGuerdie Airport
Flight #73 on June 13, end returning on June

made

thanks for your

invitation.
Sincerely yours.

,,

Max

wlr't"

Fink, M.D.

Professor of Psychiatry

MF:ig

Eat.

�</text>
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                    <text>«F V/- ?/

["1513

Wednesday May 15, 3:00 p.m.-5:00 p.m.
Side
Effects of Methylphenidate (Ritalin)
Efficacy and
for Post-Stroke Depression
Lawrence W. Lazarus, M.D., Psychiatry, Rush- Pres- St.
Luke's, 1653 West Congress Parkway, Chicago, IL 60612;
David Winemiller, B.S., Venkata Lingam, M.D., Carolyn
Hartman, M.D., Ida Neyman, M.D., Mehrdad Abbassian, M.D.,
Usha Kartan, M.D., Pauline Langsley, M.D., Virginia Markvart,
Fi.N., Jan Fawcett, M.D.
Summary:
Large numbers of stroke victims suffer significant depression
within the ﬁrst two years following stroke. Use of tricyclic antidepressants among elderly patients is often complicated by side effects
such as orthostatic hypotension. Methylphenidate has been shown
to be a rapid , safe, and effective treatment for depressed geriatric
patients.
Methylphenidatewas studied for safety and efficacy in the treatment of post-stroke depression at Rush-Presbyterian-St. Luke’s
Medical Center in Chicago. Ten elderly stroke patients with a DSMIll-R diagnOsis of major depressive disorder, a minimum Hamilton
Depression Rating Scale score of 15, and a minimum Mini Mental
Status score of 14 were treated with methylphenidate and studied
for three weeks.
Four of the 10 subjects showed Hamilton score reductions of
50% or greater. An additional four subjects showed Hamilton score
reductions of at least 25%. No subject had adverse side effects
necessitating discontinuation from the study. Five of the 10 subjects reported between one and three individual side effects.
Methylphenidate appears to be a safe and effective treatment
for elderly patients with post-stroke depression. Its rapid onset of
action and relatively low side effect profile may offer advantages
over tricyclic antidepressants, particularly in a rehabilitation or acute
medical hospital setting.

�</text>
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                    <text>1"
~

"
A

Alummwv

/

rum-1

n
-

A»

,‘Hx'n'filul‘ct'r'r'w

w‘

July 22,

www.-

an

1971

me

vww-w—pv

Dr. Stuart Lewis
Royal Edinburgh Hospital

Edinburgh, Scotland

w

"mmmtmvva

Dear Dr. Sewis,

r"
-

”,3:er

AWN-Yrmww

.11:

:-

(my-n4

I want to take this opportunity to thank you for your
patience and courtesy during my recent visit, which was a highlight
of my trip. I am impressed with the amount and variety of
work of the Department and particularly with your enterprise
in the study of heroin and cannabis.

1pc-

mart:

«Wm.

~

w

“TL-mu

7mm

Incidentally, I did arrive at Anderson's in time
helpful. Thank you for the suggestion.

My best regards to your associates, and I look forward
to continuing our discussions in Wﬂrzburg.

'5":

,

merry

:r'

uz;

Sincerely yours,

m,

2,1:

Jun

mg"

-

Max

Fink,

5'
'1‘

..

4!:-

“7"”.

..

.-

é
-.,~nvw~a—~.

and

they were most

l'ioDo

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                    <text>,

,.,.-

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...,,v_,,.

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1

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, u..-—— ,, mam-wan1?“:

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7

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,

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7

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27 June 1973

8. F. Yolles, H.D./Che1rneu, Department of Psychiatry

rink, M.D./Cheirnen, Research

Committee

FROM :

M.

SUBJECT:

Ayplicetion fbr Chart Review. Fermingville by S.J. London, 0.8.W.
reqpeste permission to examine patient records at the
Fermingville aftercare unit of 0.1.8.3.. to determine the eweilebility
of subjects tbr e doctoral thesis at H.Y.U. Be is interested in the
role prior hospitalization has on re-hoepitalisetion, particularly the

Mr. London

impact of "patient role" has on edduntnent to tumily and

to

community.

request: permission to exemine records; to use the date to prepare
e preponel fer review by Professor Whiter Heft end a committee er
5.241.; and to resubmit the final propose]. (1t reuible) for review.

He

Permission for chart review ahould be grented.

mrznpv

w r.-. “my..r...,_,_v

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,er ,..a

�</text>
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                    <text>Dacember' 26 , 1968

Library,
of Medicine
103m Street

Academy
New

York,

N .Y.

Gentlemen:
me.

If

Ir.

Rhea Dorhbush

she finds

journals, I

would

is

working on a project for

books and
it necessary to take outher
do

appreciate your letting

so.

Sincere1y ,

Max

Fink , M.D.

Professor of Psychiatry

�</text>
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              <elementText elementTextId="36022">
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                    <text>June 16, 1978
Dr. Julian Lieb
Yale University School of Medicine
New Haven, Uonnecticut
Dear Dr. Lieb,
Mr. Guillermo Paz was seen

at

my

office

was in no distress, presenting his story well.
and appeared his stated age of 30.

on June 15. He

He was

neatly dressed

principal complaints are emotional instability, depression,
tension, working up to 18 hours a day, lack cf concentration, poor
memory and inability to enjoy life. The symptoms have been present
since early adolescence. At one time, he was classified as suffereing
from hypothyroidism and took Cytomel for more than four years until
a re-analysis found that he was no longer suffering from hypothyroidism
His

'

and no longer required the medication.

Dr. Paz describes himself as a hard driving and exuberant

is in his success rates in reducing death in
cardiac resuscitation units, in maintining life for terminal patients
and his stated work time of 33,500 hours during the three years of
his training. (On calculation, this averages 214 hours a week or

worker. His pride
30 hours a day).»

His marriage

to a pathologist

and schoolmate ended

recently

in divorce, without children. He asserts that his wife failed to
understand his drive or to encourage his need for success.

has been under medication for a number of years for the
of anxiety and tension. The range of compounds is extensive
and he asserts that he has taken the medications at the recommended
dosages. For the MAOI and diphenylhydantoin, the drugs that might
be logically used in his condition, his dosages were adequate for
He

symptoms

trials.

principal quation is the suitability of BCT for his
condition. In reviewing his symptoms, there is no insomnia, anorexia,
weight loss, or dry mouth. Libido has been diminished byt his work
activity has been maintained at a high level—- averaging 16-18 hours
a day. He is of above average intelligence, critical in his
perceptions, and exhibits a low score on the California F Scale (2n).
The

�"hp—www.—

w.

I have not received the history and other medical records
at this time, the basis for the following recommendations is the history
as presented by the patient without verifying documentation.
As

It is clear that he does not exhibit the principal symptoms
of an endogenous depression; rather the syndrome seems
more like
a personality disorder of the obsessive—compulsive type.
For a number of reasons-- the absence of endogenous features,
the continued performance at work, the critical thought processes
and
the low California F Scale; the presence of anxiety and the investment
that he has in memory functions, this patient is a poor candidate for
HOT. The principal result would be
an exaggeration of the memory complaints and no relief of symptoms. Indeed, it is quite likely that
he will have more complaints.

it

While
is clear that ECT is not indicated, it is not
what
clear
measures would be more helpful. In talking to him, and
reviewing the symptoms, I enquired as to the type of psychotherapy
which hashes experienced. Is it possible that he may do better with
an approach that follows the rea-ity npﬁels used by Sullivanian
therapists ? I am struck by his drive and wonder whether his
interests could not be harnessed for his welfare by discussions of
the immediate problems in living and the realtion these problems have
to his attitudes to his family and the expectations that they seem
to have for him.
»

Thank you for the opportunity to see Dr. Paz. If the
review of the records alters the recommendation, I will write again.
Otherwise, please accept this opinion as definitive.

Sincerely yours,
,Max

Fink,

M.D.

Professor of Psychiatry

�/"‘%.

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�Appendix

Social Attitude Questionnaire (F Scale)*
are a number of statements. For each statement we want you to
give us your personal opinion of whether you agree or disagree. Answer
each statement according to one of the following:
Below

A

/

I

AGREE A

b

I

AGREE PRETTY MUCH

I

AGREE VERY MUCH

1
/&amp;/VV-9

LITTLE

1.

No

I

DISAGREE

5?

I

DISAGREE PRETTY

/ I

I

"“

5

A

LITTLE

DISAGREE VERY

MUCH

MUCH

.
.
of hurting
a close
sane, normal, decent person could ever think

125

friend or relation.

2. Science has its place, but there are many important
must always be beyond human understanding.

If people

3.

off.

would

talk less

and work more, everybody would be

better

a person has a problem or worry, it is best for him not
think about
but to keep busy with more cheerful things.

4.

5.

tion,

When

What

it,

the youth needs most is

and the

will to

work and

strict discipline,

fight for family

8. The best
be done and how

teacher or boss is the
to go about it.

to

21
A

{3/

rugged determina-

and country.

6. Nowadays when so many different kinds of people mix
much, a person has to protect himself especially carefully
an infection or disease from them.
7. Sex crimes, such as rape and attack on
mere imprisonment; such criminals ought to be

/

things that

é;

together so
against catching

children, deserve more than
publicly whipped, or worse.

tells

one who

us exactly what

is to

23’

1/

/

9. Young people sometimes get rebellious ideas, but as they grow up theyé;
[ought to get over them and settle down.
10.

strong.

M0

. .
.
People can be diVided
ten
into

.
.
classes: the
distinct

.

* From

weak and

the ’9

’////////////,
/‘.
/1ﬁ}4

Gallagher, Levinson and Erlich (l957).
Agreement is scored as +7 (agree very much), +6 (agree pretty much),
and +5 (agree a little); +4 for no response or uncertain; +3
(diagreee a little), +2 (disagree pretty much), and +1 (disagree
very much). The ten items are summed for a single F—Scale Score

Scoring:

�</text>
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                    <text>April 16, 1984

Jeffrey Lieberman, M.D.
Department of Psychiatry
Lil-Hillside Medical Center

75-59 263 Street
Glen Oaks, New York 1100‘}
Dear Jeffrey,
It was kind of you to give me a copy of "Blue Jolts'. I am collecting books
about convulsive therapy, and l have been seeking this book for a few months,

without success.

'

Enclosed is a copy of my book on ECT. There is a chapter on a “theory' of
its mode of antidepressant action. A year later, after some consultations with Jan—
Otto Ottosson, we decided to put this theory forth in a more structured fashion.
One of my associates, Yiannis Papakostas did a ﬁne job with an initial study of the
DST in ECT. Both reprints are enclosed. The Papakostas' findings have been
supported by some additional studies since 1981, and I believe them to be
essentially correct today.
Hence, my interest in neuroendocrine studies. We are collecting CSF and
blood samples in patients undergoing ECT, with two taps for each patient. The
samples will be assayed for different peptides, and perhaps we will find some
support for these ideas.

Before I left Hillside, John said that you were in charge of neuroscience
seminars held each month in the Department. If you will send me a notice, I will do
my best to attend those that I can.
My

regards.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

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                    <text>Dr.

The

A. Lieberman
mm
mimity of Chicago

Dapartment of Psychiatry
950 East 59th

Chicago 37,

Street

Illinois

Dear Dr. Liaberman:

for the request of a reprint of the article
Manta].
Syracuse”. I regret to say reprints of this article are
Thank you

"Tm Face-Hand That as a Diagmstic Sign Of

no longer

available.

mic
g

»

Simomly yours,
Max

Pink,

Director

m‘mw

.24.

n.

-

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                    <text>Jtme 1, 1965'

Dr. Tad Liebsrsm

Hines,

Illinois
Dear Ted:

very fine research assistant. Miss Pam Rosmfeld, is
getting married this week and will woman}; her husband to
A

.Qﬁcsgowiﬁminthemxtfwmeks. Bothltmltilsndllnve

fundinrwwkvexyhslpfultous, sndmammkingtm
oppwnmityofmmndingthatsheaallonyou,inﬂmmpe

ﬁtmmybcabletoassistMrinobminingapositimm
saga.
Miss

Rosenfeldesmtousabmtayearandmhslfago

as a participant in our infatuation retrieval prom. She
has assisted me imsumably in providing descriptors for
our mprints, in editing my "m3 and Hm Psychoﬁmmmlogy"
in bibliographic searches.
bibliomphy, and in assisting us
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She is now acquainted
tbs
litmtm and I believe

a valmble library assistant, either in you“ prom
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Any help that you can give her will be appreciated.

would be

m.

Sincerely yours,
D.
m
m,
Professor of Psychiatry
M-

HF:kp

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Dr. Ted Maureen

an».
Illinois

mm.

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m
m, of“on:Psychiatry
Professor
mzkp

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                    <text>April 5.

1966

Dr. K.“ Lifebitz
Research Facility

W
Wm,

Sum Pbopital
Now

York

Dearxem

Mmmywhfortmaumipﬁmofwmlim
onlibntw. Ifmuditmﬂﬂnpiatmam

Mmimimtod,ﬂmmmlimmdoumt
Mom
Mtitsnlecatimntthomdofmaigul.
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helpful.

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Ifmdﬂummtstimuthg,mdm
muldid.
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study

wow m in progress in Europe.

My

hast

NEW.

Sincerely yours,
Max

mam

Fink, H.D.
Psymiatxy

meuaor of

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w—VW

V

Aer

15. 1969

Dr. Kenneth Lifshitz
Rockiand State Hospitai
Orangeburg, New York 10962
Dear Ken,
Thank you for your inquiry regarding our paper for
the Society of Bioiogicai Psychiatry. I had hoped to
present some information from our pentothai data but these
analyses have been more protracted than anticipated. Last
month I withdrew the report.
As

soon as our present studies are completed I wiii

be giad to send you a copy.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry,

Max

MF:kp

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»

"a

-

,

ry-

.7

w

,

on...“

v ww- 'wrr‘r

«v. .m‘m—w.r—--«m\-r\nwb’aﬁww- .n. ”Upwwvw“w, .,Wﬂ_‘, ~w—r,..1.— . w—nq- ~:-I-*'\
,

4"me(((((WWIWszI—I

»Wv WWW"... 1, 7"”...rmv wwpmﬁwuumw,‘
-

V

.

.W~——.—7__o

"7

"I'F'1'3"“ﬂr‘mwwltm'ﬂVﬂﬂ-‘m'r—vmvm

April 16, 1969
Dr. Kenneth Lifshitz
Rockiand State Hospitai
Orangeburg. New York 10962
‘vr

to".

17..

Dear Ken.
Thank you

"“1WW-vﬂmrvmwwrwvyn

for your inquiry regarding our paper for

the Society of Biologicai Psychiatry. I had hoped to
present some information from our peotothai data but these
analyses have been more protracted than anticipated. Last
month I withdrew the report.

-v;—.v-v

A

soon as our present studies are compieted I
be glad to send you a copy.
As

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

nil]

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;

.

r

September 18, 1969
Dr. Kenneth

Lifshitz

Research Center

Rockland State Hospital
Orangeburg, New York
Dear Ken,

glad to send the reprint you request,
but I don't get Pszchiatrz. Please have your
Would be

secretary check your f1
Journal.

e and send

the

Thanks.

title

or

-W

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>July 1,

1964

Hiss Barbara Lightcsp
Secretary to Dr. Carl Beaver
McNeil Laboratories. Inc.
Camp Hill Road,

Port Washington, Pennsylvania l903é

Dear Miss Lightcap:

for your letter of June 26 and the check en~
I described to Dr. Beaver, the Psychiatric Research
Foundation is unable to undertake studies on behalf of pharmaceu~
tical laboratories. 1 indicated that we were interested in
including trifluperidol in a study program which is now in progress
and requested some additional grant—in-aid. However. it would be
technically helpful to no if both the letter and the check could be
rewritten to comply with the regulations of the Foundation. For
this reason. I have taken the liberty of editing both. and hope
that these corrections can be made in another letter of transmittal.

Thank you very much

closed.

As

for Dr. Beaver to call me on his return
to his office. with regard to a letter written to Dr. Gershon by

would you leave a message

Dr. Seay on March 19. 1964?

have already received the supply of tablets of trifluperidol.
In preparing our program, it became of interest to us to be able to
analyze the EEG effects on the intravenous administration of triflu—
peridol. I would be grateful for any information which you may have
available regarding the intravenous or parenteral administration of
trifluperidol, the concentration in which it may be available. and
whether the present preparation is suitable for intravenous use. If
triiluperidol is available for intravenous use, or if its parenteral
form is such as to be considered safe for intravenous use, I would
be interested in a small experimental supply.
We

Thank you

for your cooperation.
Sincerely yours,
Fink,
Director

Mar

M?/jb
Enc.

M.

D.

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                    <text>January 8, 1956

,

Donald A. B. Lindber-g. PLD.
Director, Hedioel Center- Cmputex' Frog-am

School of Mediums

thiversity of Missouri

Coma,

Missouri.

DearDr. Modest-g:
Your recent letter regarding the Medical Center oonputer
program was most helpful. Our own pmgruns are somewhat less
unbitious but have provided us with the mueuel opportunity of

workingdirsctlywiﬁ: amputerpeoplesoﬂmtwehm learned
mthing of the interaction bemen meters and psychiatric
mseemh.
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iwortmtpartofamoenterisﬁiereletimshipmiohwehave
established with the larger mater at Washingtm Lhiversity.
Dmingthepest‘omyemtheirnirectomm. RidurdDmﬁcoehler,

has provided us with advice, personnel, md more important, the
use of his larger imtnmt whenever our project required it.
Mr. Donald Shapiro who is new e candidate for the degree
D.
So. in Oanputer Sciences at Washington lhiversity, directs
of

Wemuldbepleasedtohemymvisitusmd
diswsthekindsofpmgzmwhiohmeybeofmumlintemst.
mmlebommory.

Ihevebeenvery pleasedwiththismﬂrdstretive mageinomnorh
ion and look forward to closer oollabomtim with the various

facilities of the University of Missom‘i.
IemleevingSt. lazismﬁuelnthforenmerofmeetings

mdwillretmnmtheZSth. Iftherewillbeanoooesiminthe
mtmekinJmmxyorwlyinFemmforyoutobeinSt. Louie,
Mnsmpimsndeouldbepleesedtoheveyouvisitus. Onmynext
visit to Colmbie, Iain, of me, oellywand visit your center.
Ididvisitlestmmthbutymwemnotevailablethetdey.
.

forward

I

to meeting you.
Sinceme yours ,
Max

Fink,

Director

M.D.

look

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‘

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April 2. 1969
Miss Carol Lindeman

Albert Einstein College of Medicine
Yeshiva University
Eastchester Road and Morris Park Ave.
Bronx,

New

York 10461

Dear Miss Lindeman:
Dr. Abrams and Dr. ﬂornbush were kind enough to bring
Some years ago
this interesting protocol to my attention. which
we compared
in
I was involved in a similar unnertaking
A
Indoklon.
and
convulsive therapy and electrical means
information.
copy of that report is enclosed for your
ﬂood luck

in your studies.
Sincerely yours,
Fink. £4.13.
Professor of Psychiatry

Max

Mszp

”n...“

4"

m,

L.

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                    <text>“v."

.

W":

,

1“—

April 2.

1969

Miss Carol Lindeman

Albert Einstein College of Medicine
Yeshiva University

Road and Morris Park Ave.
York 10461

Eastchestar

Bronx,

New

Dear Miss Lindeman:

Dr. Abrams and Dr. Dornbush were kind enough to bring

Some years ago
this interesting protocol to my attention. which
we compared
I was involved in a similar undertaking in
A
Indoklon.
and
means
and
electrical
convulsive therapy
capy of that report is enclosed for your information.

Good luck

in your studies.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>m.v""“"'lVVW:M‘I—V

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-

n...

Imam...“

M4,.

i...

Mrs. Tess Lindgren
CounTy of Los Angeles i969 Grand Jury
_

548 Hall of JusTica
Los

Angeles, California 900l2

Wasp-"MW-

«hum-u—

sm’g‘rvv

v

Dear Mrs. Lindgren
Thank you for your leTTer of February 5. Our sTudies of
marijuana began in November l968 and we have no conclusions
or daTa which have been published. One suggesTlon ThaT we do
have for a group of clleens like yoUrself comes from our

personal experience.

became inTeresTed in marijuana research in
lT Took us more Than i8 monThs To obTaln The
May I967.
The facT ThaT
supplies Through legal channe s - This despiTe
New
York.
marijuana is indigenous To The sTreeTs of
research
To
make
The
ThaT
encourage
clTizens
can
efforT
Any
raTher Than placing obsTacles in lTs paTh would be commendable.
We

flrsT

,n,

Sincerely yours,

,...,_x

m

“to

Max

1"WW'I-mm-n-n-v

mm-m'wwh

'h-N-vv‘r'v‘n,

v

‘,

“Wm-am":

‘r/vvvrm‘r‘i

Fink,

M.D.

Professor of PsychiaTry

wwwmawmwm-"im—

MF:kp

TV.

v

w.” w.

,

�</text>
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                    <text>August 10, 1962

Clyde J. Lindley
Executive Secreteﬁy,

VA

Cooperative

Chemotherapy Studies in Psychiatry
Peyohiatry, Neurology &amp; Psychology Service

Veterans Administration
Us hington 25, n.c.
Deer Clyde:

Would you kindly change ny address of record as or
uidoiuguet from Hillside Hospital to:
ﬂex Fink, H.D., Director
Missouri Inotituteoof Psychiatry

Shoo Areenal

street

St. Louie 39, Hieeouri

Thenk you.

Sincerely yours,
Hfagp

ax

o

,

. .

�</text>
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                    <text>a”)
¢///
February 16, 1962

01r
:

Clyde

J. Lindlaywaa

““Exncuntvamsaéretary, VA Cooperative
Chhmotherapy Studies in Psychiatry
Psychiatry, Neurology &amp; Psychology Service
Veterans Administration
Washington 25, D.C.
Dear Clyde:

enclosing an abstract and title of our
presentation in Cincinnati. Thank you for the
second invitation. I will try to make the sessions,
but am not sure at this point.
have asked my associate, Dr. John Kramer,
to audit the meetings and would be grateful for your
I

am

K

approval.

Good

luck!

Sincerely yours,
MFxgp

encl.

Max

n ,

. .

�</text>
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                    <text>July 22,

Mr. Clydn

J.

Liming], Editor

Secretary,
Win
3. Wm
U.

mm
”a

Dopartnnnt

1965

Win:
VA

of "admin. and Surgery
25,

D. C.

M W:
HoopicsofﬂuSixthWCmfcwmofm
ministration, held m 27, 28, md 29, 1961,
Mm
wand appnciarto waiving a copy.
am still available,
we

Simmly yams,
Fisk, M.D.
Professor of Psyduatry

Mam

�</text>
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                    <text>August 13, 1963

Mr. Lindquist

lenent Sonics

Minoan

Washington University

Linden E Skim
St. Innis, Missowi
Dear Hr. Lindquist:

Itmapleaswotalkimwithyouthismminsaboutthe

opportunities for research assistants at this laboratory. I
am taking the liberty of enclosing a deocription of this
laboratory written October, 1962.We now have laboratories operational in noumphysiolow
amd pharmacology, and expect the biochemistry laboratory to

fall
in the mint-ion of EEG

be naming

various

new

W

this

In nomphysiology the studies are
signals to new mugs. In phamoology,
amnicals are being tested in both animals and man.
r

principal types. of mrk are in recording biooloctr-io
in patients and in animals using high gain amplifiem,
tape moorders. moments. etc.
The

Pull tin assistants are pmfcrmd but we make adjustments
for six to tan hours of classes. The working hows can be
provided that the major portion is during the work
day of the senior soiontmt.
flunk you very mm for any assistanoe you may give us.

we!

Sincerely yours,
Fink.
Dimotor

Mm!

Khan

Mo Du

�</text>
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                    <text>June 23. 1964

Mr. Robert N. Lindsay

Chief of Bureau
701~3 Union Centre
31

Pxitchard Stroet

Johannasburg.
Republic of South Africa

01:: Hr. Lindlny:
{cw days ago. an article appanrud in the New York Times,
datollnad Prutoria, South Afrtcn, regarding a new tranquil113.3. M99. which was usdd to subdue a rhinoceros. Rd are
vnry interested in learning not: of this drug and would
apprdciatc.any information you could give an regarding it.
.npdcidlly tha manufacturer“h nuns and address.

A
'

Thank you

for your cooperation.
Sincerely yours.

3.:

Fink,
DiractOt

ur/jb

M.

n.

�</text>
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                    <text>my 9,

Ir.

Richard A.

1968

May

Division of the Social Sciences

West Texas State Unimity
Canyon, Texas 79016

Dear 1r. Lunacy:

Ymmletteraddreeudmminmmimmstbem

mivadinNawYmk. Imovodm‘twoyeareago. Ian
tﬂdngﬂulibwtyofwxdﬁugyamlemmm.mmm,
Associate Professor of Psydxiatry at the University of Miami

SdnolofMadicinearinWymomtmthimformyhelp

trutmyasaociatoaemgivoyou.

Inﬁnevmtmisoutof

tomyoumnywiahtomachm.J.M.C.}bldenatt}nm
institutim.

Sincerely yours ,
Pink, M.D.
Professor of Psydziatry

Max

MF:kp

cc: Dr. Ali Keakiner

Institute of
Mami
SHOO
Arsenal St.

St. Innis,

Wm

mam 63139

�</text>
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1968

Dr. Richard A. Lindsay

Division of the Social Sciomu
State Urdvamity

West Texas

Cmyon, Texas 79016

mm Lunacy:

Ymmletmaddresudmminﬂissom‘imjustbem
moivodinNewak. Immmycmago. Ina
taldngtlnlibu'tyofmdingywletwmm.mxwkiner,
Associate Noam of Psychiatry at the Univmity of Miami

Sdmlofhdicimuﬂlmostymoontaothimformylulp

thatmyasaociatescmgiveyou.

Intlncvmtmiswtof

tamymmywiahmmachw. .H.C.Ho1dmatthem
instim‘tim.

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airmen yours ,
Max

Pink,

M.D.

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MP:kp

cc: Dr.

A11 Knsldner

Miami Institute of Paydﬁatry
51:00 Mam]. St.
St. Innis, Miami 63139

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                    <text>my
Dr. Omen

26’ 1962

Wale:

Sate Heepitel
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Metropolitan
Walther: Sh,

D.”

D?-

“my:

Iueneleeingeeepyofthe Wofmmpoeiuheldetthemld

or peyehietry
omen
in the discussion.
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-

,

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The

reference

“eh interested

interested in an article written by

kdieimue

edditiam re

”we

be

in 1961.

‘

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5:

you

is marked

H. Helmhen and H.

«that:

361;, 1961. These
also presented
CINP eomreeaaaet Munich, September at this

authors who have dam

some work an this abject ere; F. Flugel of
klengeng P. Berene'bein cf Villejuif, Paris; end 0. Gazelle of Milen.
Parenthetioally, both Dre. Cezanne and Flugel will be at the
Sahel Conference on October 3131'. in New York.
The

An

by Dr.

additional report concerning the

Itil.
and

He

has done a

metal

EEG

is

W

included in the abetreete

and exhenetive etndy of the pentbthal
hie mung-apt: ie new in the heads of the University Osmium
response
tea- their emeiwretien for his doctorate. I anticipate having Dr. R11
cone to this leboretm-y at the end of this year. It is w hope that. we will
be able teeerryoutthe studies efegreupofeehieepbreniepetientewbohem
failed to respond to therepiee by e embimd EEG-memeneephelmephie
drug eveluetion etudy. I mid be pinned to dieenee thin with you, car - ad
ether eepeete of the therapy resistant problem, at your convenience. Let me
take thin epportuniw to extend an invitation to visit theee laboretoriee
~

w

duringyournextvieittotheﬂidweet.

Sincerely rem-e,
MISSOURI INSTITUTE OF PSYCHIATRY

Fm,
Dinette!
Mex

14an

M. D.

one.

Plane eddreee correspondence to:

51300

Areenel

Street, St. Louie 39, Missouri

�_,

1

-.

Parnate

}

brand of tranylcypromine

F01”

g

more rapid onset Of action

leaders in psychopharmaceutica] research

�</text>
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                    <text>Hey

5,

1972

Dr. Alfred Ling

Cibs Pheroeoeuticels
Division of Cibe Geigy
Summit, Rev Jersey 07901
ii

mf'w

Dear

ﬁr. Ling:

Separately, I on sending you e complete file of the dots
for our study of 69—41299 vs. placebo in outpatient anxious neurotic petionte. The study in an outgrowth of
our EEG studies, which indiceted thet GP £1299 exhibited profiles
and data analyses

similar to

domepin.

This study assessed the "anti~anxiety” component of the
drug. we were unable to examine the entidepreessnt features, but
look forwsrd to reports by others who any here been encoursged to

assess this feature.

are submitting the summery for publication to Arzneimittelforochung. The study was monitored by Edgar Grunwnldt and Vilma
Harrison. and I have sent them copies of the summery report.
We

Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
HF:ig

cc: E. Grunueldt
w. Harrison

�</text>
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                    <text>Ref: 72-326N
June 28, 1972

Alfred

C. Ling, M.D. Ph.D.
Ciba-Gcigy

Summitt, New Jersey
Dear Dr. Ling,

Thank you for your favorable consideration of our
subvention of a report on GP—41299, to be published in
for
request
Arzneimittel—Forschung. I have written to the diitor indicating

this support.

I trust the report will be useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Vlmm-Wmﬁﬂw‘wmww

W

September 12,-1972

Alfred S. C. Ling, M.D., Ph.D.
Associate Director, Clinical Pharmacology
CIBA—GEIGY

Summitt, New Jersey

07901

Dear Dr. Ling,

Following your letter of August 11, we checked our records
and sought follow-up data by phone in each case studied in the two
clinical studies of GP 41299 (your studies A69-650 and A70-1903-3).
The question of interest was whither the patients had become
pregnant
at any time during or since exposure in 1969-1970.
We traced 8 patients, and none have been
pregnant during
or within a year of exposure.
We

failed to trace

4

patients.

Enclosed are the laboratory standards in use in our
GP 41299 studies, and the changes made in
the procedures in August, 1971.

laboratories during the

I trust these data are helpful.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Bacamhar

W.

70

Lani-la

l7 .

1.952

Linn

East 83rd Street
28.

Haw York

mm

a.

'1’.

m:

my ﬁndings in your meant 1m.
u
was
WelnevarDr.gottaknnwhimmll.
Immafthemny
weekdahis emtasy. milligram
If
AW
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12m and mm ragard fur patients. Ha provided a mildew
{If a Malena 1n the
an
Marian.
m1
tn share this loss, which 18 felt by all students ofWt

I an writing

‘th

WhB

Hy

beat regards far the

ﬂaw

23w.

Sincerely

Max

We.

Pink. '14.

Directer

m

Way.

D.

51*

Elm-e

mam;

emea

to: was Arum

smut.

8%.

Lama 39. No.

�</text>
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                    <text>September 17, 1971
Dr. Ronald Lipmao
FEE—HIM}!

5600 Fishers Lane
Rockville, Maryland

20852

Dear Ron,

visited mo thuraday, and I found his study
he is
interesting, his goals a-bitioua. To the extant thorn
and
intcraated
able
wa
are
interested in evaluating drug effects,
data
about
in helping him. I gave him detailed suggestions
recording, equipment, processing costs, and soot background
of the experiences of my laboratory.
Dr. Sheard

‘

In addition, I referred him to Dr. Russell Monroe who
has a similar project in Baltimore; suggested he consider the
use of an activation test (the alpha-chloralosa procedure, for
example) to classify his patients; and wrote a letter of introduction to Russ Monroe for him. Both men have similar processing
problems, similar quostions, and in this day of limited funds, their
working in tandem may reduce their coats.
With regard to the lactate proposal, I discussed your
call with Dra. Taylor and Abrams, and suggested that they call
you directly for specific ways that they can improve their
preposal. Should they wish to re~apply and accept your advice,

I indicated that

my

prior agreement

was

assured.

for your efforts on their behalfm
9r. Sheard to me. I hope I was helpful to him.
Thanks

and

for referring

Sincerely yours,
Fink, ﬂ.D.
Professor of Psychiatry

Max

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        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50454">
                <text>Correspondence to: Lipman, Ronald</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50455">
                <text>Text</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="50456">
                <text>mfp-05-00-025-7-468</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50457">
                <text>1971 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50458">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50459">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="50460">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50461">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50462">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="50463">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="79248">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="85809">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="92370">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="98931">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
