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                    <text>November 2, 1965

m.

R. C. Posse

Mediulninctor

Dorsey laboratories
Box 1113

mnmln, Nebraska

68581

Dear Rey:

in e

Inplwedtomcloeeeemuyofmobmim
study of the HES effects of pymvalemne.

mum

In edditim, the proposed protocol for continued study and
its first mdifieetim ere submitted for your considere-

3don.

to the costs of the first ttudy, our biggest
in
the peymt of volmteem and tedmicime.
were
'me Pmﬂm would eppmeiete lemma-at for theee
as suggested in your letter of April 30. “me
emanates Research
Pmdetim is e nan-profit
Psychiatric
and has an why-r idemifioatim
of 33-07858”.
With mauve!

ewe

me

am

mtim,

pmposedamdywinenmeeminmoftwelve

snmjem.1n order to provide Mute
date far analysis, we would anticipate requiring fifty sessions.
me direct
plus multetim fees for data analysis
and the written repeat bring the coat to sumo.
md probably fifteen

We,

Thmkyoufcryourpestintemstandlhcpethatwecm

mtinue this study prom.

Sincerely yome ,
Hex

Fink,

PM).

Enemive Director

Hf’mp

cc: Dr. Ulett

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W13
I 8am Brokers

W

Mr. 011m
A. G.

Ernst
St. touts, Missouri
Durﬁr.

#09 North 8th

mm:of

It was kind

As you

you

to reply to Hr. Stuart's can.

well know, this gift of four slums of Mimaoata

Wmmwtudnsmstodcmpmsentstm
first neuritic: in the PWm‘s portfolio;

m

mermdatimwﬂlumﬁmcfmdsmsupportim
few
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yamithnbwthannihbiutyofsmhmmd
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wwfwismterthcmingyear. 12100ka

W

tomingyouf’ridayaftomommatwrmtingm
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31:100me your: ,
Max

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min

8. 8mm:

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                    <text>Jammy S,

Mr. Oliver
A. G.
2:09

mm Sons, Brakes
March 3th Street

..

-\:r»

,1

:&lt;‘.....,.v.,v,.v

—..—»

WWI—WW.“

&gt;ku—vvfrg—v-W

8

St. Lads. Nissan-i
Dear Mr.

ngenbergi

Wan

After you'left the mating the Board voted Mr.
Director with mmibmty
to be the Assistant
m1:
Iorﬂufinmd‘lmmimofthefmndnﬂm.

Win

melmesim
themmmdthemoluﬂmsumtmlhnfmmmd

nquinsambmknmmiutim.

muons?

Wyoumoeaxainformmﬁbuﬁm tot‘m

Foundation.

Sincerely
NI!

PM,

yuuxfs .-

”.13.

Martha Director

”7.1“

Vw‘wﬂmvmww—mmm

1986

«clam

.

�</text>
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                    <text>W
Hsrch 2. 196‘

Mr.

allvsr

H.

Lsagsnbstg,

ﬁscrstsryurrsssursr

Edvard Mslltnekrodt Foundation
409 north Eighth strut:

St. Louis, Missouri

Best Hr. Langsnbsrg:

I should liks to sdd uy thsnks to thus: of Dr. Ulett. for
you: gift on bshslf ef the csschtug snﬂ rssssrch pragrsms
at tbs Foundstion. I am writing to clsrtty s proposed
stipulstion of this award, which is not seated in your
lstcsr. I: was origiaslly suggestsd that funds of tbs
Eduard Halltnakrodt Foundation might be used to support

s rssssrch scientist working at tbs uissaurt Institute of

Psyahigtry,
F0110”

who

would bs nsasd as ”aﬁvsrd Hsllinnkrodt

s

I! sash s designation is permissible. I
:9 work one tbs

dststls of

would ha

such s dsstgnstion.

plssssd

In tbs svsnt that the Halltnckrcdc‘vnundstton slants not
an consider such s fallousbip dsstgnstton, the funds will
bs ussd as dsscribed in your letter of Fuhrusry 2‘.
Thank you vsry much

{at your tntstsst

and support.

atnnsrsly yours,
M“ Fink. Mont
Essaunivs Dirsccnr
Hrljh

�</text>
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Mr. Oliver M. Langenberg

Secretary-Treasurer
Pomdatim

Edward Mallinckrodt

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I look forward to the scientists making
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their cmtri-

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                    <text>March 17, 1971

Dr. Theodore D. Langley
Research Neurophysi‘ ogist
Ocean Systess, Ines

Tarrytovn Technical waster
Tarrytown,

New

York £0591

Dear Dr. Landlay:
The dean of our graduate school,¥Dr. Tabachnik sent us a capy
of the biographical sketches of Ocean Systems employees. The note,
that you are developing "a computerised systes for recording and
analyzing brain waves" interested me. Two units of this Department
are actively involved in such work. '

interest is in_relating changes in the background
EEG to dose, type and duration of
drug
adninistration.‘ Our system is based on an IBMJIBOO control computer.
Our own

alert (or sleeping)

report is enclosed.
Dr. E. Roy John, also in this Department, analyses the responses
evoked to repetitive stimuli, and uses the PDP—lz.
A

copy of a recent

If either system may be related to your work, or that of Ocean
Systems, I would be pleased to hear from you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M?:kt

cc:

A. M. Freedman

Dr. Tabachnik

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                    <text>“nu-Av]?

—.—-rvm,~a-.-~mww .

n -.:.r-

.1“

;‘ch-

~

~

music...

January 12, 1972
Y.

Langlois,

M.D.

Pharma—Research Canada, Ltd.
Pointe Claire, P.Q.
Dear Dr. Langlois,

I have been delayed in completing the protocol you requested
by the ongoing wprk, but will complete the program outline shortly. The
data submitted is sufficient for my purposes, and we should plan to
start the pilot phase with doses of 25 mg, and increments at this
dose.

To

compare the compound with fenfluramine

will require the

be able to
availability of this agent in identical capsules. Will you that
we obtain
arrange for.the supply of this standard or is it expected

this

compound

7

Thank you

for your interest.
Sincerely yours,
Max

Fink, M.D.

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                    <text>February 9, 1967
Mr. John Langone ,

Editor

Psychiatric Opinion

Nine Vernon Street
Framingham Centre , Massachusetts 01701

Dear Mr. Langone:

very much for your kind imitation to amplify
on our experiences with LSD. My associates and I, being
Thamc you

of the need for better documentation of the
problems of
acperinlentation, prepared the report which
you read in the Mchiveé 06 Genmﬁ PAgdLémy. It represents
the best we could extract from the available data. Unfortunately,
the study of LSD has been a side issue for us and we have not
paid as close attention to the personality aspects of all our
patients as we did in those who had canplications. For this
reason, it would be difficult to write a scientific report of
some merit since almost all the data that we have is already
painfuny

aware

LSD

published.
We

must decline, therefore, your kind

invitation, and

trust that we will have more rigorous information of interest
to you at a later date.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

1‘11“:qu

�</text>
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                    <text>Febtmuy 9, 1967

Editor
Psychiatric Opinion

Mr. John langone ,

Nine Vernon

Street

Ptamingham Centre, Massachusetts 01701

Dear Mr. largone:
Thank you very much

for your kind invitation to amplify

on our experiences with LSD. My associates and I, being
painfully aware of the need for better documentation of the
problems of LSD experimentation, prepared the report which
you read in the Mchévu 05 Genuwﬂ Pégdbiamy. It represents
the best we could extract from the available data. Unfortunately,

the studyofLSDhasbeenaaide issue forusandwehavemt

paid as close attention to the personality aspects of all our
patients as we did in those who had complications. For this
reason, it woihld be difficult to write a scientific report of

mmitsincealmostallthedatathatwehaveiaalmady

published.
We

must decline, therefore, your kind

trust that we will have
to you at a later date.

invitation, and
of interest

more rigorous information

Sincerely yours ,
Fink, H.D.
Professor of Psychiatry

Max

Mqua

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                    <text>Gatobar 22, 1963

Dr. H. Lentin
55

.

MmetueRoed

London S.W. 19, England

Dear Dr. Lentin:

planed to receive your letter “pressing an interest in ﬁrmer peymiatric experience in the States.
We

were

At

the present time, the St. Louis State Hospital has en-

pendedite treeteentendtminingopemtimebythe mentionefm
academic researda center. This center, called the Hieemri Institute
of Peyclﬁetxy. is pm of the larger hospital and has as its model the'

meeemhmtreiningpmmeimmtoﬁmecfmeﬂeudeley.

metpmunteveimm inthe clinical services.
Ineeohservioe,ttummdevelopingmempewmdt}mem
Poeitione

Hemmetudyingeuohpmblem
pertofthelmtitete'epmm.
withdrawal of Mammvior,ﬂ1eineetlueffemofmlete
flmnoeofLithiuninmmetnentof’dnmxiestate, the application of relationship trump}: (mains) in the eev'ere chemically ill,
psychosis.

mmmmmmofmmmnminmmec
£61m
7

Fun ywr list of credentials, you appear eligible.
certificate, however, is prerequieite to appointment.

The

Imencloeingefoeml epplioetim foreppointmnttothie

ﬁ"WWﬂ.
Wimt
We.
to
for
certificate, will
we

196H.

be able

consider you

mﬂmyoﬁ‘h’éi‘é’é."ﬁes"
appointment

I look fteward to hearing from.you.
Sincerely yours,
Fink,
Director

Max

Mfzmlg

Enc.

2

M. D.

for July,

�</text>
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                    <text>October 28, 1953
11’.

Latin

H.

Wmm 19.
55

W

Road

SOHO

mm.

lantin:

Thank you very much

My

I bulievc that

'

for your recent latter. In reading this.

M

you wmld be qualified for a staff positim.
pesitions
carry an mun]. salary of $13,000, but agjustunnts
can; be mad: for experimae and qualifications.

Ihnve

1:5)th libertyofwzitingtoagoodﬁdmdefmimin

mgland, Dr. James Marga-ism, who is at the Institute of Psychiatry;
Mandalay mspit‘al. Dammu, Lawton, 3.3. 5, England, and I
would appmciate your calling on him.
.

Imualsolﬂcatohaw Zuaadditimalmfemsifymcam
Many

thanks for yew inquiry.
8111013me 570%,

Max

MPH»

.

cc: 1». James Margariam

Fink,

muster

My Do

�</text>
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                    <text>Ember

16 , 1963

Dr. H. Marin
55

mm

Lmdon S.

.W.

Road

19. England

Dear Dr. Lax-min:
‘

Imdelighmdﬂwtymhwanopmmitytowm

Ween.

the facilities in 31:. Louis fm Dr.
I have taken the
liberty to write to Dr. Patersm and Dr. Pemim rowing your

applimtim.

mm Wang an appointment, it would be may

to complete the application form which was sent to you in an earlier
Upm receipt of this, and a mall photmph, if poammioatim.
1‘
be able to complete the processing of thin applioation.
should
aihlo.
me mm of mngionis an imlevant me.
In rereading two of your latter-s, I fim a mmber of gastime that may not have boon
Paydxiatric appointmts at
this facility am on a lmg~tem, full-time basis. All paydaim‘ists
are assigns towork with patient populations. In
the work
Wis Wham, but this is wdificd toauitﬂwmdsafthepm—

mod

31m and the projects.

more are

mutant»

ml.within ten

.m

aim” of the Institution, bath for rent and forging. to a physician,
living. TM»:
themluiesmsudxastopzwideamtoomfoﬂable
are, in whim, 5 mm of small perquisites which my mﬂfy the
of national
salary on? pmvida funds to attend the
matings

min-

rims. Ammberofmmofwrsmffhavohadtlnoomimalmady

�Ir.

H.

Lantin

Hammer- 16. 1963
Page The

to visit ather- citioa in the united States and am 0110mm, during these visits, to spend a day or two of their holiday.

Ilodcfmtobaaringfmym.
Sincerely
Max

rim,

Director
MPmlg;

yam ,
H. 1).

�</text>
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                    <text>Pebmry 10. 19“

ﬁt. 8. Lunttn

55 Augusta: Road

“3&amp;0“.

S 53?. 19

Englané

Dear

at. Lantin:

for yaur lettcr of February 2. In another
indicnaad to an that ha had an upperBr.
Margarisan
lactar,
dineusa
with
to
you year prapasad emigration to the
realty
States. B: may have indicated that I planned to coma to
England, as indgad I have, but my plans have changed so thtt
I 9111 not he in Europe until the tall.

Thank you vary much

Emigration is always a majo: stay, but I havn funnd life
8:. Louis a most pleasant experiance. It may be helpful
you to know that my patentg emigrated ta thia country in
when L was a child. I have lived was: 0f my life in Raw
and came here anly two yanra ago. There was a period a:

for as, but 1 found
friendly and pleasant.

want

much

in this

1n

far

1925,
York,
adjuac~

community which was

Thare are a numbnr of strung Jewish communities in St. Louis.
and they reflact-tho diffarenees in our faith. Jews hava been

integrated in chi: community for meta than 100 ynnrs, and that:
arc 1 via. range at parachial schools as wall as community
cantor: and tynanaguea catering to tha naaés af our faith.
I would guano that that: arn a: least 60,009 Java in this city.

'

oxenllant. While I gava eonsldurucion
children
to a private schoo1, I fcund that eh:
to unnaing my
had
school:
¢ommunity
all the facilitien, 1n¢1uding foraign
Inngunga éducacton, npnctgl training in mathanaciel and science.
an&amp; a good grounding in the social 3ciau¢¢s, no I alected to
3036 my thrac.childx¢n to the community cehooll. My elaoctatts
hlVG dons 11k.viuo with tho excuption of on». who dastraa his
son to htvn a Habrcw caucation and is sending bin to a Talmud

Community achaoln urn

‘03.!)u

�Dr. H. Lancin
2~10-6&amp;

Page Two

I

trait than:

cenunnc: Innuur Iain

at your tunadt;te quctctonn,

ind I look forward to tuning you tn 8:. Louis.

Sincorely yours,

an: Fink.
Director

MF/jb

H.D.

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                    <text>April 1. man

Br.

21.

Lamin

mm
33.
W3
55

W

33:”.

Road
19

12mm:

Itmldboaplomtahawymvisitﬂ. Madam
mtmowmskmymmudngwwxmdmm
mouse. WStataHupim. Mowingiwyw

moppwtunitytomtﬁuovarimmbmofﬁm
staff.
caudally Dr. Who,“
of tho divisim.
m m».
mutt,“
Home your mmt fw «2131mm «wine that
period, I have mfmd tho latter to the Sam-winter»

mm swam.

dontsimﬂnmmtismwlmmdnwmwm

Matchmdebyhim.

'

Simuly yam.
Max

,,___‘,,A

m...

.,.,’—,V

M

~00qu

MF/jb

“FA-w

W”,

““7

v..."—

.

wvr-W

Pink. H.

11mm

“
V.

an:

Dar. Ray

Kmulca

3).

�</text>
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July 17.

1964

Dr. H. Lantin
55 Augustus Road

"London

8.

England

W.

19

Dear Dr. Lantin:
Dr. Blot: Ind I will both be in London on August 29 and 30.
W: are scheduled to stay at the Strand Palace. We can either
call you upon our arrival. or perhaps it wnuld b: better for.
you to contact the

Snturday morning.

hotel 61th:: late Friday-evening or early
Sincerely-years,
Max

rink.

Director

um»

M.

D.

�</text>
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                    <text>Fabrunry 5. 1966

H.

Peta: Laqucnt, 8.9.

Coordinator, Group Without

Nana

Grandson: State-aoopital
Quaan. Village 27. Eur York
Dear Doctor Liqueur:

It

in unlikuly that I will be able :9 parttatpato 1n the syuponxun
and of Hatch. 1 will. hovuver. try to attund tn. lasting
and vauld be grateful for capie: of the progtnu,1£ they It. and:
up.

at the
8006

Ink.
Sinsaroly yuurl.
Max

Fink, ”.3.

Director
par/3b

�</text>
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                    <text>November 15, 1994
Dear Dr. Lasch,
I recommended Norman Endler: Holiday of Darkness: A Psychologists ’s
Journey Out of His Depression, originally issued in 1982 by John Wiley &amp; Sons in hard
cover, and re-issued in 1990 in soft cover by Wall &amp; Thompson, Toronto [6 O’Connor
Drive, Toronto Canada M4K 2K1]. I do not know any other testimonial that is as
effective in portraying the tragedy of depression and the recovery process.

It is kind of you to ask about my lecture schedule. I am scheduled to
present an ‘Update’ on ECT at a professional meeting in New York at the New York
Hilton Hotel on Saturday, December 3 from 11:45 to 12:30. The conference is a joint
presentation of the Albert Einstein College of Medicine and the American Society of
Clinical Psychopharmacology. Unfortunately, they are requesting hefty registration fees,
and I am not sure that you will get your money’s worth. A more productive meeting on
ECT will be held February 27-28 at the Ritz Carlton in Naples, Florida. Those sessions
will be led by the nation’s leading therapists. A brochure describing the course is, as yet,
not available but an inquiry can be directed to Dr. Charles Kellner at the Medical
University of South Carolina [803 792-9072].
I am pleased that we were of service to your mother. I can claim little
credit since her care was under the direction of my co-worker Dr. Laura Fochtmann.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>February 19, 1971

4

0f

you go send an the

articlc

from Mexico City.

«in; to find the programs and so

tried a press

'ariety in the reports is intartsting.

~'es are continuing, although slowly. 'We have
father
:9 square to Motroyolitan and so see yourwork
I
and
the
hope
$g.no of your agpointnant,

Sincsroly yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>February is, 1966

I». Mono Lake
Cutout» Center Research Facility
Rockland State Hospital
.

Omgeburg.

Bar

New

York

Gem,

mmkaimimitationtopartioipeminm
atmeworld Cameos. I
symimmmuterepplionim
willworkomﬂmechtails
ofmysmrtripswithinﬂzemxt

fwmokamdwillletyoukzmbefomﬂnendofﬂxemﬂ:

Wlmperdoipete.

For your infmtim, I am enclosing two copies of the
write-up of our information retrieval system. This now has
then one truism-ad citations and while these an fowesed

m
on the subjects of

EEG,

psychophemoolog and certain

aspects
of permption which interest :3, it nukes a good demonstration.
If one wished, special article acquisition lists could be added
for a demonstration plume.
-

I will

mm96st prom

the EEG
and our applications when
with
I visit
you.
other thing being‘unoaqalicated, I
will plan to visit on 'Ihmday. February 1').
ﬂy

best regards.
Sincerely yours,

m
m, ofHID.Psydxietry
meeasw
'

�</text>
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                    <text>Pebrmry 8, 1966

Dr. Ensure Lenka
Rocklam State Hospital
Grmgeberg, New York
Dear Gene,

Ilookforwardtovieitingwimyoum'mmday. Iwilldrive
fmmNewYoricandatmldbeatymmlabomtorieeaboutlleOan.

Itwouldbefimtomtwiﬂxnr.Harper, mequeetimmthmted
tediemswitheeor‘gesmemmﬂmexmrimeeewithlmgmﬁng
thathehaahadewerienaeeboﬂn
Itiemyimmeim
and

form.
We
Atﬂntimeyouealhdlweemlearbutthemwaswther

ﬂuphemzim.

with the

the enmthete

Watyamlabomtorieswlmemrkwewemmlhlioaﬁng I
Wwﬁﬁnﬁuﬁm. Ifheieavailable,1

recounting

umldlihﬂmeopportmitytomtwithhimtodiscmeour
cyclceerdne

Ilookfmwardtovisitmgwiﬁayoumdwinbrmgafew2x2
made

slides so that

any discussion our: be

more

"scientific."

Sincerely yours ,
Mex

Fink, PM).

Professor of Psychiatry

�</text>
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                    <text>April 7,

Dr. Eugene Luke:

01mm,

Ompum

W
W,
Research

Facility

1966

Wt

State Ebspital
New

York

Dam Gem,

maimed is a copy of the abstract which Don and I have:
submitted to the Warm
of Psychiatry. I would appreciate
cumin-ac
at the World
your notifying the appropriate

Was

ﬁntmnismmﬁmforﬁnmmim,

We

auditwwldbo

appmpriateifhemaoliatedintmpmgm.
We

will prepare a final museript diving the next

few weeks

Mtrytomtthemtlatdudljm. Immtsmaato'me

mammdmtimmdmldapmciammmmm
m.
V

Ifldomtmmyw. Iwillaasumethatitis

appmdmataly 20 minutes in length.
Again,

my

thanks format-kind invitation.
Sincerely yams ,
Max

Fink. 14.5.

MW of Psydliatzy

�</text>
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                    <text>October 27 , 1966
Dr. Eugene Laska
Rockland State Hospital
Orangeburg, New York
Dear Rene,
Enclosed are prints and legends for our report
"Digital Computer EEG Analysis in Peydmopharmacology. "
On some of the prints I have the negatives, and
if the
printer prefers getting those, Iwould be glad to make
than available.

IwillcallyouaboutNovember7,andhopetosee
ywsoonthereafter, Mybest regards.
'4t'v

Sincerely yours ,

av"

.—,-

w,

p.

Fwy—q

war-«v

.4

‘:m',

v

awn.—

v-r'n-v’.

'

Max

rink,

M.D.

Professor of Psychiatry
MF:)q&gt;

�</text>
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                    <text>Decanber 20, 1966
Dr. Eugene Laska

Director, Camuter Facility
Bodclam State Hospital

Orangeburg,

New

York

DearGene,

Iamdelightedthatyouwillbeabletoparticipatein

the discussion of the "Application of Digital Computers to
Psychia " which is planned for the staff of the Department
of Psychiatry of the New York Medical College for January 20.
The presentation takes place at Metropolitan Hospital, 15th

flooratnoon. 'I‘Mfullsessimtakesalittleoveranl‘nur
and my report will occupy 25 to. 30 minutes. Your discussion
sinuldbeplsnmdforlSminutes. Acopyofthetextofa
chapterinaforthoaningtextbookisincludedandthiswill

be the basis of

presentation.
The usual audience size is about forty staff authors.
Projection facilities are relatively poor and I prefer to
my

use hand-outs.
Again,

my

thanks for accepting

bestwishas fortheNewYear.‘
'

this invitation.

Sincerely yours,
Fink, NJ).
Professor of Psychiatry

Max

MP:kp

Hy

�</text>
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                    <text>March 21, 1967

Dr. Eugene Laska
Computer Center

Research Facility
Rockland State Hospital
Orangeburg, New York
Dear Gene,

I have recently had the opportunity to review sore studies
with phenothiazines and noted a citation which is not available
to me. Is is possible to make a copy of your report ”Dose
Response and Bioassay for EValuation of Psychpharmaceuticals"
which was presented at the CINP available to me?
Don

Shapiro has decided to join the

facility at

New

York

delighted. The first programs for
the 1800 are still in the process of being debugged, but they
have promised delivery in early May so that with sane luck we
will be operational by the end of the year.
Medical College and

Many

I

am

thanks for your help.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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«~

u

leu—vwrv'rr‘ww-"

y

.

was“

mw‘syvsqr—

February 3, 1967
Dr. Eugene Laska
Rockland State Hospital
Orangeburg, New York

wrung-r

9

ml?‘

”-1

“wwwmmw-f

Dear- Gene,

It was

a pleasure to have you visit and discuss the
presentation. Hem Brim remanded I speak to
Dr. Welch. I have done so and enjoyed the meeting very
mch and I am grateful also for this moonuendation.
Please accept the enclosed dxeck as a small Mnorarimn.
My

best regards.

Mﬂwuxv

‘1
"-‘1:

Sincerely yours ,

.‘H'I'n;

Pink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April
Dr. Eugene Laska

Director,

,

Computer

6,

1967

Facility

Rockland State Hospital
Orangeburg, New York
Dear Gene,

Enclosed are the corrected galley proofs of our contribution

to your book. You will note that I have made some suggestions
for headings since the text seems to require some separation

between sections.

I

surprised that there is no request for reprints. It
helpful if these could be provided and I hope
this is merely an oversight on the part of the printer. Wethat
are
anxious to have reprints available for the technical documenta—
tion of this problem in our field.
am

would be most

’

Incidentally, my congratulations on receiving your ccnputer
grant. You are undertaking a nonmental piece of work and I look
forward

My

to hearing

more about

it.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
MP:qu

�</text>
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                    <text>May

a,

1968

Dr. Eugene Laska
Rockland State Homital
Orangeburg, New York
Dear Gene,

I have received the reprints of our article in your
I am writing to inquire whether copies will be
sent to authors.

book and
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

14?sz

-n-—4v

“,1

‘
,r

Tuwyl

‘13-?“

�</text>
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                    <text>”WW.

w.

.v “‘3‘“

nvw-‘w~,w.w a."

m.—

ruwl-y-

trm‘ rvtlmv .

-..w

Bovuibor 213$, 1972
Eugene M. Laska, Ph.D,'.
Research Centcr,
Boekland State Koayital,
Ortngdburg, 3.1. 10962.
Dear Gene,

I hava been published in

German, Csech, and Turkish

—'

but the Rutaian was a first. 12in pletsod, and cansratnluto
you'on the industry which fblterod this necompliahnsnt.
.

My

congrutnlgtiom

,_

m but roman;

Sincgrely yours,

?1nk,
Professor
Mn:

NF/id

M.D.

at Puyuhiatry
.

W::EFF—R‘-w_—x~mv-ﬂ .7“

�</text>
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                    <text>April 1.

1964

Diraator of Computer Cenccr
Rockland State 30:91:31
Ornnaoburg, New York

”.5! m. Lu“:
Think you vary much for your littﬁt. It was a plousura to have
Dr. Ella; vlnlt with us. and I leak forward to having you step
1n during September. I will be away during tbs first ten days
of 3gpteuber but should ha avallabla thernatter for thc remainder
cf aha mouth.
'

clan, our major intareat is in the application of
this luacrunant co the analysts of the EEG signala. we are
dcvotlng almost all our enargics to this project, which should
haw: n :aasonnble canclunlon by the middle of April. I unuld like,
at tbs: time, to 199% into the two additional problcun - ch.andan.
in
of a computer in a raactloned tine axperimencal situation,
The
in
complicated
of
sealaa.
vatloui rating
the analysis
ltttar I
ptoblcm bacnuua w¢ are still in the process of devising the acalcz
which may bu applicable to our patient pogylatlons. I hepc that am
will have some material available by the summer ting.

At tho present

Fbr aha prasanc. I hgvo uncd ch: cnmwutar to carry out various
eormulaulon analyncs and on. factor analytic using data from an
35:11:! ttudy. It was cxzrnmuly useful for than. opotatloas, ex»
cap: that the zinc invulvld was great. Since I have a 7072 availabla to me at aha University, I hnvu faund it morn cxpediaac raetntly

to clrry on: th-ne :nnlysca using the 1113.! unnhlna.
I look forward an seeing you and discus-lag this Eartha: in September.
‘

In uh: mutating, I an an¢lollng an abstrnet of tbs
v.3 pruscntod iron the computar cantor.
Plan‘s give

my

best regard: to

first

study which

Dr. Kline.

Slneuruly yours.

’1“. H.
m
ﬂirtator
Hr/jb

Ema.

D-

�</text>
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                    <text>~

7
v
-

m':

.n'vr'r-v-«cr'

"v“

r-r

nu

May

1w

YWW“W-mrw

Mrs. Lorraine Lasker

Research Administration
York Medical College

New
New

V"

v.

11, 1971

York, New York

—~—-w

Dear Mrs. Lasker:

Mr.

RE:

Comparison

of Accelerated

Convulsive Therapies

I would be grateful if you would respond to the note
Parris regarding our study of BCT.
ECT

remains the principal, effective therapy of psychotic
In comparison to antidepressants, all studies have

depressions.
shown

it

from

to

be more

effective in

outcome and more rapid in onset.

Since 1966, nuptiple treatments under oxygenation have received
special study with good results.
The principal defect in ECT today remains the 5-8
for treatment, particularly in suicidal cases.
.vr

-v’S

‘-

W

“'1'"wa

"172W?“

w‘vwmsmmm'um

ECT

is

an

active treatment at Metr0politan Hospital.

Contrary to the consultant's opinions, ECT is now receiving
additional study because it's efficacy is not duplicated by drugs,
particularly at such centers as Harvard (Drs. Schildkraut and Katy);
Johns Kapkins (A. A. Kurland); Washington University (Eli Robins);
U.C.L.A. (A. Mandell). These scientists are actively involved in
re—assessing ECT and this study is part of the renewed interest.

since 1954; and this project is an effort
It’s relevance to suicide and
I
did
is
Al'hough
depression
high.
not carry on studies in 1962-1968,
I have renewed my studies because the newer techniques offer special
I have

studied

ECT

to answer a public health question.
Wrmw.

.,.’

t

m

m

a.

‘an

.

.

,.—..

'mmwwm

days required

possibilities to reduce hospitalization

and

suicide.

�Mrs. Lasker

~2—

May

11, 1971

In addition, I have been asked to edit a special issue of
"seminars in Psychiatry” (Grune and Stratton) on ECT for February
1972; and

on ECT

to

be consultant

in 1972.

to

NIMH

in an international symposium

are continuing to treat our patients with ECT as the staff
I hepe you can allow these trials of our techniques
so that we can classify the issues of frequency of seizure and
We

recommends.

electrode placement.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

cc:

A. M. Freedman

�</text>
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                    <text>738B~538

m
1a;
w.

,n

“mun

February 16th, 1973
Hrs. Lorrainn L‘aktr.
Research Grants Adminiltration,
New York Mbdical College,
106th 8t. and 5th Ave.,
Haw York, H.Y. 10029.

'

Wm;

2w.

V,‘v-

Dear Lorraine,

v
n

)uw—A-y-msq'wurr,m.v-

r.l?-"r.wm~

vn-z

I have Just rennivnd :nd read thc knnusl Rupert a: the
Renaurch Committee for the Farina chains June 30th, 1972.
This is an impresnivu daeument and reflects a great deal
of work, particularly on ynur part. Considering the severe
cutbaak in funds, the flat levnl sustaineé betvean 1969 and

is a credit to the faculty.

1972

r)

x want to thank you for making my aervige on tbs
research ecunitteo so ple;unnt. I take this opportunity
ta extend my rasignation. as I am now almost fullntime at

my new

vnnxuru.

Fw'bast regards.

slnaorely ynura,

his: Fink, 3.1).

Profnasor of Puyehiatry

NF/id

�</text>
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                    <text>March

Dr.

J. J.

5,

1970

Lasky

national Institutes of Mental Health
lOAlO Barlow Building
5454 Misconsin Avenue
Chevy Chase. Maryland
Dear Jack.
I am pleased to enclose five copies of the report
"Lateralized EEG Changes after Unilateral and Bilateral
Electroconvulsive Therapy", as requested. In addition I
am also enclosing a preprint of a manual of convulsive
therapy which we have submitted to the APA for publication.
In presenting the principles of this treatment to our
residents, we found the usual texts to be incomplete and
we wrote this document as a teaching device.
My

best regards.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp
ENC.

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                    <text>February 21 , 1967
Dr.

Julian J.

Leaky

Executive Secretary
Mental Health B Study Section
Division of Research Grants
National Institutes of Health
Bethesda, Maryland 2001“
Dear Dr. Lasky:

RE:
.

MH

13619-01

If possible, it would be very helpful to me if the
site visit could be arranged for April 10 , as this

Blaohly

will coincide very well with another trip

If this is

satisfactory.

West.

.

not possible, the other dates will be
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>February 8, 1967
Dr.

Julian J.

Lasky

Executive Secretary
Mental Health B Study Section
Division of Research Grants
National Institutes of Health
Bethesda, Madyland 2001:;
Dear Dr. Lasky:

RB:

PH

13619-01

I have read the proposal of Dr. Paul Blachly and will be
pleased to participate in the site visit. I have been acquainted
with Dr. Blachly's work for some time and believe it important.
prefer planning a visit on a Friday or a anday,
some of the travel to take place over the
weekend. Except for the period March 20
22, and April 14,
the
scheduled
have
during
last half of March
I
no engagements
31 - April 3 or
March
be
would
My
for
preference
or April.
7
10.
April Perhaps, the most important part of a site visit would be
dermnstretion
by Dr. Blachly of the technique which he is
a

I

would

thus permitting

-—

using.

If this

can be arranged, and an opportunity provided

the patient a few hours later, or to examine a
to
patient treated earlier in the week, I believe a more reasonable
examine

opinion regarding the safety of the subject can be provided.

Because of my special interest in the EEG component of this
program, I would urge that you ask Dr. Blachly to provide an

opportunity for his electroemephalographer to review the

partoftheprogram.
Tharﬂc you for your invitation and the opportunity to
participate.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

EEG

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                    <text>v...

‘

'4'”mwm'yvr,~&lt;—rmv&lt;-wc'

arm-w

December 20, 1967
Dr.

Julian J.

Lasky

Executive Secretary
Clinical Projects Research Review Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Jack,

writing with regard to our application for
“Theoretical, Clinical Studies of Convulsive Therapy.“
I am

(MH-lSSGl—Ol).

Since a number of the reprints are no longer available
file copies, I have arranged for xerox copies to
be made. Enclosed are five units which include representative

except for

reports related to
My

my

studies of the convulsive therapy process.

best wishes for

a Happy New Year.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
P.S.

I am also enclosing a reprint of a report
who is working with me on this project.

of Dr. Abrams.

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                    <text>December 23, 1971

Julian J. Lasky, Ph.D.
Executive Secretary
Department of Health, Education, &amp; Welfare
Health Services &amp; Mental Health Administration
National Institute of Mental Health
Mr.

Fishers Lane
Rochville, Maryland 20852
5600

RE:

MH18490—03

- Kurland

Dear Jack:

It

was kind of you to give me an Opportunity to see the menswand thus get a follow—up of the progress on this study. There
has been much effort eXpended in planning and equipping the EEG analytic

al request

portions of the study; the promised participation of an electroencephalographer. (Dr. Bohm) is no longer listed in the renewal or the progress
report; and 16 patients have had records analyzed on 3 or 4 occasions
during the ECT process. The principal focus seems to be on the EEG chang—
es induced by ECT and this is reflected in the large supplementary request of $36,000 for specialized EEG equipment.
A. Two observations have stimulated these workers. One is
the increase in podt—seizure alpha activity is related to a better clin—
ical evaluation, and increased theta/delta activity with lesser degrees
of improvement. This observation is reported as “contrary“ to that of
others. But, the study is not a replication, and many factors that influence the EEG expression are disregarded.

l.

The EEG

is recorded in the ten minutes before the

ECT

treat—

is given, presumably in the treatment room. This is a time when
anxiety may be intense and which may alter the EEG. Prior workers did
not use this method, probably because of its lack of stability. (Is it
ment

—

�ht. Julian

J.

Lasky, Ph.D.

December 23, 1971

not also likely that many of the patients will have received some anxiolytic therapy before the treatment
perhaps not for the psychotic
depressives, but surely for those rated as depressive neurotics?)
——

2.

any measure of
ing the amount

In the

EEG

evaluation, a difference score is used, without
The sample size is 10 minutes, and considerbe artefact filled, it would be a surprise if

variability.
that

must

the pre~sample, on which the results are highly dependent, is a reliable
estimate. (One should expect an awareness of the variablility of the
EEG and estimates of variance to be included in the
analyses).

3. The post—ECT assessment is at 43 hours. Rﬂilizing that
there is a decay in the amount of slow waves, and that this is most rapid in the early treatments, the authors now suggest estimates continuously
during and after the seizure for one hour; and again at 24 hours. Are
they implying that this pilot work was wasted? Would it not have been
useful to examine a few patients at various times and present this data
for a new study?
4. The records were evaluated for normality. By whom? With
what standards? One of the main reasons for the emphasis in the 1950's
on quantitative measures for EEG evaluation was a difficulty to achieve
agreement as to normality and abnormality among sophisticated EEG'ers.
The authors have more than adequate equipment to provide preetreatmeut
estimates of the amount of various frequencies, the amount of variability
in amplitudes, egg, « and to use statistical techniques to allow for the
relationship between these measures and change with ECT or with clinical
evaluations. But they eschew these techniques for an earlier technique,
which I would consider less reliable.
B. The second focus is the isoelectric period after the sei—
zure. This important observation follows the reports of Paul Blachly.
The observation here is contrary to those reported by Blachly, and inde—
pendently observed by my associates. Could it be that some of the isoelectricity that is measured is an artefact of the blockade of the amplifiers? This possibility is not mentioned. If the observation is valid,
what possible explanations do they have, and how do they propose to ex-

amine

it

further?

Perhaps the biggest disappointment is in the behavioral
In any correlation, the highly sophisticated analyses of
one variable (EEG) ought to be matched by equally detailed and time~re~
lated behavioral measures.
C.

observations.

1. There is one clinical psychiatrist assigned to the project,
so his observations must stand alone. He uses standard, gross measures
of behavior and the results are couched in the grossest estimate of 'im~
provement'. Improvement in what? Mood? Affect? Sleep? What of the
contamination of memory loss to the overall assessment?

�Hr.

Julian J. Lasky,

condition,
few.

December 23, 1971

Ph.D.

The authors use a fixed number of treatments. Under this
some patients may receive too many treatments and some too

2,

It is probable that psychotic depressives, the older patients, will

reapond to the extra treatments with memory loss. Hence, they hay be
evaluated poorly if memory is an integral part of the improvement evaluation. These patients may also show more slowing, for this correlation
increased EEG slowing and decay in memory function is well established.

~

3. Using their ratings for behavior, and assigning a value
of 2—3 eps from the graphs, we find the following:
amount
to the
Rating

LE;

1

7

23

l2

4
5

2
3

Mean

"delta"

5.7
2.0
3.0
7.5
7.4

I do not find their tentative conclusion, that delta increase
is associated with lack of improvement to be well grounded.
of the

Also, the behavioral measures are presented without making use
today.

statistical techniques available

is disappointing. xot uecause the authors have
presented little data, for they have made a good effort to get started
on an interesting problem. They have fulfilled some of the goals prom~
ised. But, the report shows a lacs of involvement by clinical psychie
This review

trists

with sophistication and hnowledge of the issue involved. The rem
newal focuses on gadgets ~ $36,000 of equipment for engineers, and no
funds for the researcners. Replacing some of the clinical funds and reducing the equipment would do little to improve the project, for it is

clear that the important investigators are beipcl and brown. If one had
much money, perhaps the $16,000 for each of 2 years may serve to keep
the project going at its present level. The electroencephalographic portions are also weak, and this may reflect the lace of someone with per~
sonal experience or involvement with this instrument (the promised ap~
pointment of a neurologistnelectroencephagrapher did not materialize).
I regret that I

cation. In

my

am

less than enthusiastic about this appli~
was optimistic that the problem may ex-

earlier review, I

cite the staff to a productive involvement ~ but this has not occurred,
and I am not sanguine that another two years would add much.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig

�</text>
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                    <text>~¢ w

Julian

an

«mmyvﬂww? rsavrm»

,-——-‘—'7- -

K

«ww—
«rm-«paws-»-mwv-n.-rmwrnwrwwwmnr

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Eof:

""1me

Dear Jack,

w:

n—u-

”win-VW'.‘

W.Vv—¢A

.

WW

Wu...

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~

"W,

,

.

EXHER

M323152~01

AM lo the proposal, ”Malamute of Schizophrenia by
E .3" has imartmt and interesting goals, the methods

".7,me

wuw—

-

March 23, 1972

E. Laoky, Phi).

Hational Institute of’Mhntal Hoalth
Bookv’llle, daryland

.
.

wvw-va,

Regressive
are
inadequate to tho task. Should ﬁlm Committee wish to encourage such
a program, it would lo advisable for the investigators to diamos
two isouao with otz‘zoro: tho lrztomlatimzo of modifications of the
363‘ prooeoa to therapeutic outcome, and the; isouaa in quantification
of the EEG. In Million, since the min «Issues in regrosoivo EC'T from
a public hoalth point of view are the long Mm affects of multiple
seen as an aaeault on the central nervouo amt-om, particularly
“lama,
on masuree of brain Motion and on such oapaoitloa as concentration,
mmry, and thought prooooaoa, the evaluation of nouroZOgloal deficits
and poyoizologéoal taste focusoad on what is usually called ’organioity’
must be considered.

“.I-vv‘wrrnr—y

investigators have done an interns ting clinical study
in oohiaophranio patients. There is a need for such
a ra-evaluatt‘on of regressive 3‘02”, for this modification has a chequered
history. Older atudiee fomd it rarely useful. Recent studies of multiple

of mgroealve
‘

,
am

mzwwnmvvvmwmw

«A;

A-"ﬁz'sv

362’,

The

EC?“

under oxygenation control,- kave indt'oatod

safe, pmduaing no

that multiple

ECT

are

mmry lose, nomlogioal deficits, or EEG
changes than slnglo E63". Unfortunately, multiple E02” only occasionally
produces better results than Mingle ECT in depressed patients. Tho data
for schizophrenic patients is unclear, hmwr; and than now are some
reports of better results: with multiple E’CT. Thaw data mantra verthe proposal 2):; Row:- warrmta some
ification, and in this
assistcmann its present form, it is inadequate to the make outlined
by the investigators, and suggostod by my view of the public health issues.
more

erk,

favorable features of the proposal:
is adequate, and the setting is probably a good one for
such studios. (In our investigations of ECT at Gracie Square and Hillside,
was in those small hospitals that the staff were favorably diaposed tp
it
EST, allowing the investigations to proceed.)
The

1) the population

2) The investigators have an

interest and

some

experience in rograsaiva

EC’T.

�EXNE’HOOIOIIOOIOCOOOOODCOIOOIOOQII

2.0.00.00090000. We}: 33’

1972

3} 2%3 PI ochibits statistical and doeign sophistication, and his
rocord as pcychomotrist is good.

Iﬁo negative fhaturoc

of'tho proposal:

1) The aeaign is ECT vs. drug treatmont. This £8 not the most important
locus, but were it the doslgn to be followed, there are specific problemc.

2)

change

Wﬁile the evaluation mothodc may be adoquato lndicoc

in porconallty and behavior, the issue in gogroacivo

ECT

of

is the

impact on lntorporoonal behavior, neurological dcflcltc, thought
processes, momory, and cmontraoion. In their first study, they
emphasize a porcictonce of’somo of’tho thought disordcr~u but is
it difforont and how is changed ? The clinical aspects seem inadbquatcly
covered, and the omphaois on a psychiatric interview no less than 30
mdnuteo and no more than 45 minutoo is mochaniotic and loos than helpful.

it

ovaluction is at thoworong time for any important
ghoulﬁ be evaluated coriatlm (weekly) to assess
tho rate and dogroo of’chango in brain function. But wool critical
is the likolikood that the patiouts will all rooeivc drugs aflor the
treaomont oourso. Yﬁo druggcontrolc of'nocoocity; the EC? patients
most probably. Slﬁoo no statcmont is modo about the specific drugs,
dosages, and relation of EEG measuroa to drug intako, I have to asaumo
the investigators are not acutely awaro of'thc impact of'drugs on the
EEG. To unravol EEG effocts of ECT from drugs without attention to
the controls necessary, is exceedingly dlfflcult.
Iﬁo

EEG

issue. Porhaps the

EEG

fﬁe samo problem in the evaluation and followmup will
what {a the impaco of’drugc given after
EU?
tho
EC?
on
rogroacivo
prococc, and on the compariaoo of'ECT and
drugo 7 (For thio reason, I would favor rogrosolvo ECT vs single ECT).

occur for other indicoc~~

Patient selection is

3)

XII-Mr.

,

an

issue.

The statement of’procoas
doccribad are too nan~spcciflc

schizophrenia is inadoquato.
tests
to help othera define tho population. It were better for the investigators
to specify which criteria of’prococc schizophrenia thoy use (3.9. Fish,
Eoylor, others ?). Paychological tests are supplementary~~ they cannot
be used as the diagnostic critcria.
Too

criteria

on

while I'am not ordlnarily prone to question selection
ethical groundb, in this instance, the authors should be

asked to make clear aomo of'thcir minimum criteria of’prior treatments
and failure, recent treatmont and failure, etc. bcfbro rogrcssivo ECT.
Should not all pationtc have had a course of”rcgu&amp;ar' ECT and failed ?

Poychological teats arc given heavy emphasis, but the
more selected in not indicated.
Why the MMPI and the SRSC ? Noithcr is aulecicntly speciflc in its
interpretation to be very helpful.
4)

theoretlc bass from which these touts

�EXNEktiioﬁioIOODOOOOOCDIOOIOOOCO

3

OUOIOQCOOOOOCO‘IOIOOWh

I)

There are many problcma with the
the ctudy could be done without EEC moaaurcc,

EEG

33’ 1972

measures, but cincc

I will not

go

into full

datail of’thcinadbquaciac. It to not clcar why the invcctigatorc are
measuring E33 affccte, for the only specific suggestion comoc from the

dhscriptéon of’lack of’abncrmallty bcfbro and after troatmont, as
evaluated by tho neurologists on visual lncpcction. Etc issues
that could be investigated are the difycrancca in EEG offhctc of
rogroscivc EU? to other EZﬂk the rate at which the induced changes
disappear; the relation of‘changa to improvement, to memory cffhctc,
or to other neurological indlccc.

They cuggcat quantiftcation cf'thc Eﬁﬂg suggesting
rocording and analysis for chart epochs. Tﬁc equipmont they
request, rcprccenttng a large part of'thc budget, to adoquatc only for
the analog to digital conversion, and some simplc ctcpc of'data reduction.
But EEG data it voluminous, coon when reduced, and the interrelations
among many chancclc a horrcndouc tack. (Ihdocd, vary for investigators
have challenged more than one or 2 channel data, and tf’morc, only for
1 0r 2 minute cpochc).
8 channel

Their interest in sleep EEG to unjustified in the protocol.
cbcn suggest sleep EEG recording (8 hours), for 8 channels (I),
to so voluminous a tack, tkat I cucocct tlcy do not moan this.
suggestion about doing visual analytic of'tha sloop records to
interacting, but this too to a big task) and will not in thctr
for cares, answer any of’tka quattcac. The same problem of'drug
control must be considorcd hero.
Eb

thir

I

10

l

4

1h rcwrcadﬁng thic proposal, I believe the investigator
bringo to the questions, posed by his clinical colleagues, and cxpcrlcncc
at a clinical psychologist and psychometrtctan. Those aopcctc scam well
handled. For ’ccicntlfic' reasons and interacts, they are suggesting
EEG analyses, sleep recording, and some fblloa~up studies. It these
aspects, they team to lack experience, but alco cuffictcnt judgmont to
visualize the tasks and to obtain advice. Earhapt, more they encouraged
to visit and work with one of'thc untoercity based centers studying
EC? and on: focuccad on quantification of’thc EZEQ these issues might
become clearer to them. ware they then still interacted in the studies
auggoatcd here, a better propoaal might (?) to fbrtkcomtng.

to a clinical
better atatamcnt of the
population, assessment of'ncurologtcal chhcto, control of'ECT paramctarc
and drugc, ctc.~« and a contribution madc to the EC? literature. In the
Alternatively, the dcctgn could

replication of their pilot study, with

some

be reduced

latter case, the budget could to subjected to rcqorktng; dblcting
sleep and statistical consultants ($8300), equipment ($30,300), and

E36

chart paper ($600); with additions for neurological evaluation.

I trust those comments are helpful. you already know the
laboratories
interacted in those iccuac, and I am confldont
principal
that any would be interested in this study.
Stnccroly yours,
Max

Fink,

MI

D.

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                    <text>~“K‘

“-‘mw‘vﬂrw-‘m'"' mm run: n“

"Km 7

‘

»-

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.Y,

‘_

March 33, 1972

Julian It. Laoky,
ﬁational Institute of'obntal Boalth
PEAK}.

ﬂockville,

234m land

Eef: mom

M23158~01

Dear Jack,

While the propocal, "Treatment of'Schiaophrenia by
important and interesting goals, the methods are

EU?" has

Regressive
inadequate to

it

tile?

wish. to encourage such
tho invoctigatom to discuss

task. Shoula tho Comrlttoo

for
a program,
'tao loouoo with others: tho lntorrolationo of’modiflcations of‘tﬁe
EC? process to thorapoutlc outcome, and the ioauos in quantifloatlon
of the EEG. In addition, since the twin leouoo in rogrosoivo 3326‘? from
a publéo health point of'olow are the long torn offocto of‘multlple
ooizuroe, coon as an assault on the oontral nervous syctong particularly
on matures of brain function and on ouch capacities as concorztmt’lon,
momory, and thought processes, the evaluation of‘nourological doflcéts
and paychologicol tosto fbouoaod ow what to usually called 'organiolty’
must be conoldored.
would be adviecdalo

The investigators have done an
of'rcgrocoioe EC? in schizophrenic patients.

interesting clinical study
There to a mood for such

a ro~ovaluatlon of’rogroaaivo ﬁll; for thin modification has a chequered
rarely useful. Recent otudloa of’multlple
history. Oldor studies found
Elf; undor omygonatlon control, have indicatod that multiple ECT ans

it

dofloito, or EEG
soft, producing no moro momory loss, neurological ECT
only occasionally
changes than single ECT. Unfortunately, multiple
produces bettor results than single EST in doproeood patients. The data
for schizophrenic patients is unclear, holevor; and thorn now are some
roports of'bottar results with multiple ECT. Those data require vorifloation, and in this framowork, the proposal by Ewnar warrants some

aselstanoo.1h its prooont form, it is inodbquate to the tasks outlined
by the investigators, and suggested by my view of the public health ioauoa.
5%:

favorable foaturos of the proposal:

1) the population is adequate, and the setting to probably a good one for
such studies. (1h our investigations of ECT at Gracia Square and Hillside,
was in those small hospitals that tho staff’wore favorably diaposod tp

it

Elf; allowing tho inventigationa to proceed.)
2)

Tﬁo

investigatora

have an

interact and

coma

experience in regressive

ECT.

�.-&lt;

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3) The PI

..

.

.n,

.

‘n'mgrﬂwrr

:IWBst"-v~l*’!‘-vm

March 23’ 1972

sahibits statistical and design sophistication, and his

rocord as psychometrist

../.,._~

~....-_».-r.~n.

is

good.

"7”,

The

negative features of the proposal:

1) The design is EDT vs. drug treatment. Ihie
the design to be followed,
issue, but were

it

is not the

most important

there are specific problems.

While the evaluation methods may be adequate indices of
2)
change in personality and behavior, the issue in gegressive ECT is the
impact on interpersonal behavior, neurological deficits, thought
processes, memory, and concentration. In their first study, they
emphasise a persistence of’some of the thought disorder—- but is
and how is
changed ? The clinical aspects seem inadsquately
it different
covered, and the emphasis on a psychiatric interview no less than 30
minutes and no more than 45 minutes is mechanistic and less than helpful.

it

,

ihe EEG evaluation is at thewwrong time for any important
issue. Perhaps the EEG should be evaluated soriatim (weekly) to assess
the rate and degree of change in brain function. But most critical
is the likelihood that the patients will all receive drugs after the
treatment course. The druggcontrols of‘neeeseity; the EC? patients
most probably. Since no statement is Mada about the specific drugs,
dosages, and relation of.EEG measures to drug intake, I have to assume
the investigators are not acutely aware of the impact of drugs on the
536. To unravel EEG effects of BCT from drugs without attention to
the controls necessary, is exceedingly dijyicult.
Zhe same problem in the evaluation and followvup will
occur for other indicss»~ what is the impact of'drugs given after
regressive EC? on the EC? process, and on the comparison of ECT and
drugs ? (For this reason, I would favor regressive ECT vs single ECT).

3)
Patient selection is an issue. The statement of'proceee
schizophrenia is inadequate. The tests described are too non~specific
to help others define the population. It were better for the investigators
to specify which criteria of'process schizophrenia they use (3.9. Fish,
ﬂuylor, others ?). Psychological tests are supplementary~~ they cannot
be used as the diagnostic criteria.

criteria

While

I

am

not ordinarity prone to question selection

ethical grounds, in this instance, the authors should be
asked to make clear some of their minimum criteria of'prior treatmonts
and failure, recent treatmont and failure, etc. before regressive ECT.
Should not all patients have had a course of 'regular' ECT and failed ?
4)
Psychological tests are given heavy emphasis, but the
theoretic base from which these tests more selected is not indicated.
Why the MMPI and the SPEC ? Neither is sufficiently specific in its
interpretation to be very helpful.
on

.

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23’ 1972

There are many problems with the EEG measures, but since
I)
the study could be done without EEG measures, I will not go into full
detail of’theinadequacies. It is not clear why the investigators are
measuring EEG effects, for the only specific suggestion comes from the
description of lack of’abnormality before and after treatment, as

evaluated by the neurologists on visual inspection. Ihe issues
that could be investigated are the differences in EEG effects of
regressive ECT vs other Elﬂk the rate at which the induced changes
disappear; the relation of change to improvement, to memory ef?ects,
or to other neurological indicee.

They suggest quantification of'the EEG; suggesting
recording and analysis for short epochs. The equipment they
request, representing a large part of'the budget, is adequate only for
the analog to digital convereion, and some simple steps of'data reduction.
But EEG data ie voluminous, even when reduced, and the interrelations
among many channels a horrendous task. (Indeed, very few investigators
have challenged more than one or 2 channel data, and if'more, only for
1 0r 2 minute epoche).
3 channel

To

is

Their interest in sleep

EEG

is unjustified in the protocol.

eben suggest cloep EEG recording (3 hours), for 8 channels (1),
so voluminous a tack, tiat I suspect they do not mean this. gheir

suggestion about.doing visual analysis of the sleep records is
interesting, but thie too it a big tack, and will not in their
few cases, answer any of the auctions. She came problem of drug
control must be considered here.
#-

10

d

J!

.Ez.reureading this proposal, I believe the investigator
brings to the questions, posed by his clinical colleagues, and experience
as a clinical psychologist and psychometrician. fhese aspects seem well
handled. For 'eeientific' reasons and interests, they are suggesting
EEG analyses, sleep recording, and some follow~up studies. In these
aspects, they seem to lack experience, but also sufficient judgment to
visualize the taske and to obtain advice. Perhaps, were they encouraged
to visit and'worh ith one of the university based centers studying
ECT and one focussed on quantification of the EEG, these issues might
become clearer to them. were they then still interested in the studies
suggested here, a better proposal might (?) be forthcoming.

Alternatively, the design could be reduced to a clinical
replication of their pilot study, with some better statement of'the
population, assessment of’neurologioal effects, control of EC? parameters
and drugs, etc.—- and a contribution made to the EC? literature. In the
latter case, the budget could be subjected to reworking, deleting
sleep and statistical consultants ($3800), equipment ($20,500), and
EEG chart paper ($600); with additions for neurological evaluation.
helpful. Iou already know the
I trust those comments are
these
laboratories
in
interested
issues, and I am confident
principal
that any would be interested in this study.
’ISincerely yours,
Mam

Fink, M.D.

.

u--- .

.7

.,.r

,.

.

_.

�</text>
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                    <text>'i

WWWA

.2:

02

73AP-826AP
20 Docnnbcr 1973

Garald L. Klerman, M.D.

Suparintandent
Erich Lindcmann Mhntnl Health Cantu:
Government Cents:
Boston, Mhasachuactts 02114

Duar Gerry:

records are incomplete, but this lettar from A1 Freadmnn
suggests that no rcviov the £110: for an invitation to Dr. June
Christmas.
my

If aha was invited, pcrhaps thc Mbmberahip Committee would
reconsider extending anothcr invitation.
Ifisho has not bocn nominated, perhaps w: can write her,
taking for but C.V., and thnn proccsl it with letters of rccom~

mondation from.A1 Ergoduan.
My

bcst ragards,
Sinccrnly yours,

m Fink. Hobo
MF/cis

�</text>
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January

ll,

«wwvv—mmrmrmmwWLWVPr—v'
,

l968

Dr. Francis Latteri, Chainnan
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

First

York, New York

Dear Dr.

Avenue
‘

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan Hospital. Such events were occasional
early last year but have became increasingly frequent.

Clinic

'

staff of the Department of Psychiatry have reviewed
of the newer dosage farms of established pharmaceuticals and
would like to recommend that these be made available.
some

Also, the

May I

and would

agenda?

inquire as to the next meeting of the

it

Pharmacy Committee
be possible to have these two items placed on the

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

ﬂszp

�</text>
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                    <text>January

ll,

l968

Dr. Francis Latteri, Chairman
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

York,

Dear Dr.

New

First

York

Avenue

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan HOSpital. Such events were occasional
early last year but have become increasingly frequent.

Clinic

some

would

Also, the staff of the Department of Psychiatry have reviewed
of the newer dosage forms of established pharmaceuticals and

like to

May I

and would

agenda?

recommend

that these

be made

available.

inquire as to the next meeting of the Pharmacy Committee
be possible to have these two items placed on the

it

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>April 12, 1968
Or. Francis Latteri. Chairman
Committee on Pharmacy and Formulary

'

l East 105th Street

New

York, hen York l002‘9

Dear Dr.

Latteri:

At a meeting on April l, of the Psychopharmacology
Study Group - a committee of the Department of Psychiatry

«

four compounds were recommended for inclusion in the pharmacy.
These compounds had been requested by members of the staff.
They include flophonazino onanthata, haloperidol. thiothixene

and tybamate. The Committee‘s recommendations have been approved
by the Chairman of the Department. Dr. Alfred M. Freedman.

Fluphenazine enaothata was recommended for admission of
a new drug to the formulary. for use limited to the Department
.

of Psychiatry.

lhe other three compounds were recommended for

trial periods of 6 months and that the manufacturer be requested
to mate trial supplies available to the pharmacy.
If these recommendations are approved by the appropriate

committees of the hospital. I would be pleased to arrange with
the pharmaceutical concerns involved to make the supplies

available to the

pharmacy.

‘

Sincerely yours .
Max-Fink,

m.

Professor of Psychiatry

HF:kp

cc: Mrs. Cruzado

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                    <text>April 8, 1968
Dr. Francis

Latteri,

Chairman

Cami ttee on Pharmacy and Fomulary
l East 105th Street

New

York.

Dear Dr.

New

York

Latteri :

associates and I have reviewed the requested application for admission of a new drug to the Formulary, meclizine
My

hydrochloride.
The

literature indicates that this compound has specific
which no other compound is readily available.
is recommended.

indications for

Approval

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="107011">
                    <text>May

Gabriel Laury,

Box A

13, 1977

M.D.

Kings Park, New York
Dear

&lt;&lt;

.
.,

l
w

A.

-..v

‘VE'H'D'HVJJIwn-ffvgg

Gabriel,

I am embarrassed to put you to this difficulty. I
did apply for the transfer in 1975. and then promptly forgot.
Once, a member of the Suffolk Branch called to ask the reason for
my transfer, and I explained that I no longer participated in the

New

York

District Branch affairs, and that I wished to attend some
now that my principal site

of the sessions organized in Suffolk,
of work was the University.
I never heard

inn-7.“.

from the Suffolk branch

after that.

,

:-

.

the

&lt;A

w

New

Recently, I

was reminded

that I was still a member of
I resigned two years ago.

York branchu- a membership which

,
.mr»

.w

-::

'r-rux"

If there is some problem in accepting this transfer
application, please let me know.

lair—1‘1"

mnw.~m&gt;nx¢w—u

Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

�</text>
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                    <text>September 6, 1963
Dr. mlvinlax
3llAsl'eIoodFoad
New

Providence,

New

Jersey

martial:

Wemverypleasedtcmceiveymmcardmman.
the

Thematlwnaticians
peychophatmcologists. The

toget together allommemrld juntas
pastyewhesbeenamsycm.butwithinthelastfewmnths,Ihavehada
seen

established. It ermld not be too long before I can see
prom
myweycleartomvelingagain.
umber of

»

The

children are fine and are well establiel'nd in sclml.

Our

biggest

difficultyis thatMarthahas to spendmchofhertime transportingthe
children. Despite this, she is «trolling at Washington University and will

tryto gethwhastersineducetionintwoyears.
I

am

waiting today because

I

have a

specific antimalarial problem.

Youmay recenthatIhavebeenintmstedinneammingbrainwavepattems.
’lhe first laboratory I established at this Institute was for such recording
and with the help of the Washington University Camuter Center. have set up
a local IBM 1710-4620 system. I an mw able to convert the mica sigmls

ardtomyoutammbercfmlyaes. unfimtpmmmtwaewritten

for a "period analysis". this prom gives us the man freqwxcy, the
s time of specified frequencies and the mean mlitude for spams of any size.
Atpmsmt,mmtnrkingwithl. 2 1/2. ands secondepochs.
was

In discueaim the analysis of smh data with various statisticians, we
to a statistic desctibed in 19k). by Bon Home: (Amulet Hath.
19bit
12: 153, 367). the statistic is the new square successive
Statistics,
difference. In lacing through the mime, I fomd other articles by Yang.
were recommended

Imuderifyoucouldhlpmeinthefcuwingm?
mutistmpmemtstam
Do
which have been described?

of this tecrmique?

you

low of

any epplicaticne

Isthmarggemmltextﬁmtdescribesmelimitscfthiemm?
Itmgocdtodmatwithymdming

luveachametobringthefamilyfaetm

recentvieit. IdohcpeIwill

misfauandenmldliketc

callyouﬁim. Mybeetmgamsthudy.

Sincerelyyom,
MEX

Fink,

Director

Me De

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                    <text>War It, 1963
Dr. Holvin Lax

Laboratories
Tum
main.ﬂomeay

Bell

Dar Mel:

foryoxmlnttormdywcmmntswhiehl
Wyn:
bolimmmntmdmrmct.
A

Iplantobcinﬁaw‘lcrktmﬂmtpartofmam
to visit the New Jersey Memo-Psyduiatric
Imtitute mthe mingofnaoewer 5 (mmdny). That intim-

and have an apportmity

timisinhinaetmmdifwgeogmpbyismcmitshandtm

unomﬂmmhmmtcmmwamﬁm.

Woulditbepmaiblefwmmvisitywlaminmaftab

noon (MOO pan.)

onthat day,

spmdmtim with you. mdjoin you

Ifﬂutiamtamodtiu,lplmtommrﬂnmkform?
mmwmmwmmmtmsmwmmy?
WMt-mmtoJudy.

Sincerely yours .
Max

Fink,

Director

ﬁnale

H. D.

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                    <text>member 23,

Dr.

mlvin

1953

Lax

Bell Telephone laboratories

Mar-my

Hill,

New

Jersey

DearMel:

It was a great pleasure to spend the aftemom and evening
with you earlier this math. Judy's dimer was deligxtful and I anjoyed every minute that I spent with ywx‘ mildmn. Their enthusiasm
about schooling in England has provided an addod incentive for Martha
and me to outsider taking time ordldmn to Europe for the summer months
next year. I mndor if it would not be a good idea to try to enroll
Jmathan into one of the camps which are multilingual?
I must also tell you that I enjoyad my visit to the laboraexhibits were wonderful and even for an amateur sophisvary immssive. 93 you know. I am very much interested in
the speed} pattom studios. I
if it would be possible for your
librarian to mks available to m the mfmnoes daswiptive of the
meals in the exhibit?

tories.
tioate,

The

Mr

Upmmymtm,1fmmdthatmyassociataahadoamiedouta

Wear:

of the power spectrum mlysis.
umber of investigatian. A
and the baseline arms analysis of the own data indicates that we have
some diffemooa in the two tedmiques. although they are mom similar
than diffomnt. It is oy intention to
both methods over the
next fw weeks and then discuss these observatiam with a oonmi‘ttoo of
for our mating in Washington at the and of
elootmphalonm
Jmuary.

m

,

'

'

for your helpfulness and for the opportmxlty
to visit with your family. My best wishes for the New Year.
Again. rig thanks

Sincerely yours.
Max

Hf'mlg

Fink,

Director

H. D.

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                    <text>..
.p

Annammhwwu

.

.-

ﬂunk,”

E

,i

I
,F

.-

_.,

nunum" whim—m

w‘wmmw“

,

_

F'Www‘ww‘m-“mr‘

a]

-

ww-

,

,

xv:-.

.m-m

,

,

W:

7333~78953
28 Hovuﬂbcr 1973
Dr. Lyle K.

Hillcr

Sankara Pannsilvania Psychiatric
Philadalphia. Ponnnylvania 19129

Institute

Dear Lyla:

I want to thank you for spending so much tin. with Rank
:nd myaclf yesterddy. I found the V131: valuubla in helping
us to undaratand ch: studies which you havm dun: during the
past

few

years.

I read the draft of the taper: of the atudino of acru a~10
1: uttnizhtlorward and have two
on ch: way home. I think
ouggcctionl. 0n the batten of Pan: 1, max: to the lane 1135,
should rnad ACTK 5~10 rathct than kCTH 1~10; and on Eng. 3 ch.
mathod of Experiment 2 could be clearer
tho ward "intra—
venous” were added nonuvhqru in thc mathod.

it

it

Conaidnring the nuﬁbar of variables which havs been teatad,
Benton taut might
have occurred by chancn? In 1: not this 1::un-«and, perhaps, aa
undarstanding of how it cana about—~that should be ch. focus of
a ouccaading study?

is it not poaaibln that ab. diffuroneu in ch.

A331n.

Dr‘cory

my

thanks for the Opportunity to

viait

your 1ab~

o

Sinceruly yours.
Fink, M.D.
Professor of Psychiatry

Max

HP/cia

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                    <text>—

.1...

February 7, 1970
Mrs. Lala 8. Le;
Chairman, Ccmmittee on Mndicine &amp; Law
Association of the Bar of the City of
42 what 6k Street
ﬂaw York City

.Mpv..§.x.as~.r:-w.wsuw-

It

of your committee to invitc us to participate
in the symposium on marijuana, and we enjoyed the sasaion very much.
I rcgrat that our participation was limited to audition. since
there many inputs raisad and can» facts presented that were in
error. The issue of marijuana is in the public eyn. and the
extan-ive penalties for possession are indead absurd and dis~
proportionate, and this was clearly atated by Dr. Mead and Er.
Rothwax. Unfortunataly, both ﬁt. Rainlip and Dr. Zinbatg mgde
misstatamtnts of fact~~ Mr. 3513119 in regard to the studies
of THC and the allegad toxicity of cannabis: aad Br. Zinbarg in
not distinctly aapnrating the toxicity of opiataa from cannabis.
wan kind

Whila the problem of marijuana in acutc, the prablems
dopandencc and their treatment are not only as acute,

of opiate
but the severity of the illness is so much greatmr, uni the
'epidemic’ so much more severe, as to be a public health problem
of major magnitude. The legal issues of entorcad engagement with
methadone~« an oxperimontal drug~¢ or the justification for
incarcaration without traatmaut may have been discussed, but
sacm to us still :9 ba open innues. Ferhapa your committee may be
interested in discussing these problems at another occaaion.
Again,

1114mm":

x

York

Beat Mrn. Laa,

”hamburg,

”WWW‘MA”,

N$W

your excallent

my

wife and I thank you for the invitation and

haspitality.

Sincerely yours,
Fink, 24.9.
Prateasor of Psychiatry

MRI

uf/

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                    <text>January 24. l968
Dr. 8. A. Lebedev

medical Officer

Mental Health Unit
World Health Organization
Avenue Appia
Geneva « Switzerland

lle

Dear Dr. Lebadev:

It was

good to hear

that

you are

still

considering a

meeting of investigators interested in international studies
with psychotropic drugs. Our study programs with the

University of Istanbul are progressing well, and it is on
route to that Center that I plan to stop in Switzerland.

I am confident that Dr. Itil would be pleased to represent
this program. He is PrOQEssor of Psychiatry at the University
of Missouri School of Medicine and holds a concurrent appointment
at the University of Istanbul. His address is:
Dr. Turen

M.

Itil

Professor of Psychiatry
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri

My

63139

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>“

warw-

9'H1‘r"l'l"

~rv&lt;

Lyuvw’s’r-"IKJ'VII'

:—

rw—xr

W

.qq.mxmmwpm,y-w.

Jmmry In,

1986

Dr. 219mm! Iabmsohn

c/o Centml Office
Mariam Psychiatric Associatim
1700 Eigxteenth

Hashing'tm,

no.

Street,
20009

2M4.

Dear Dr. {abensohm

Follming the request

at Mr.

Robinson for copies of our
of the American Psychiatric
Anuoeiatim . I am pleased to send you eolitho copies of our
M1 report. his will, of course. be edited to be
within the time limit of the mating. ﬁmever, thispremtad
report

apart for the

1966 meeting

my be of assistance in the
Hy

war):

of your

mines.

best regards.
Sincerely yours ,
Max

Fink,

Md).

Profasscr of Psychiatry

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                    <text>July 21, 1982
Paul Leber, M.D.
Acting Director
Division of Neuropharmacological Drug Products
Food dt Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref:

1ND

12,987 (ORG 2766)

Dear Dr. Leber,
Please allow the scientists at the Pharmaceutical Research Institute of
Worthington, Ohio to cross—reference the information in our files of the ACTH4.9
fragment known as ORG 2766 (IND 12,9 87), effective immediately.
Thank you.

Sincerely yours,
Max Fink, Md).

Professor of Psychiatry

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                    <text>StonYBrOOk

Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (516) 246-2413

v

October 18, 1982"
Paul Leber, M.D.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref: IND 8,569

-

~ACTH4_10 (OI-63)

Dear Sir:
The sponsorship of IND 8,569 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

Sinc ely yours,

JM

Max Fink, M.D.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone; (516)246-2413

StonyBrook

October I 8,

19 82

Paul Leber, M.D.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 12,238 —- GC-46
Dear Sir:
The sponsorship of IND 12,238 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

Si

M

erelgours,
£14»!
V

Max Fink, M.D.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony BrookStony Brook, NY 11794
telephone: (516) 246-2413

StOHYBIOOk

October 18, l982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 12,987 .- ACTH4_9 (ORG 2766)
Dear Sir:
The sponsorship of IND 12,987 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

ﬂ!
Sin

relgurs,

M—

Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (5 l 6) 246-2413

Stan-YEW0k

October 18, 1982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref:

1ND

13,059 -'ORG 2566

Dear Sir:
The sponsorship of IND 13,059 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

W

erelyjurs,
Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (516)246-2413

StonYBl-‘OOk

October 18, 1982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref: IND 13,060 — ORG 2313
Dear Sir:
The sponsorship of IND 13,060 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

Lia,“
//
Si

erely yours,

Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook
Stony Brook, NY 11794

StonyBrook

telephone=(516)246.2413

October 18, 1982
Paul Leber, M.D.
Division of Neuropharmacological Products
Food 6c Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 14,915

-' ORG 3770 (6-azamianserin)

Dear Sir:
The sponsorship of IND 14,915 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.
’

d“

Sinc ely yours,
/./l‘
1

,

Max Fink, M.D.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook
Stony Brook, NY 11794
telephone: (516)246-2413

StonYBIOOk

October 18, 1982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref: IND 14,963 -~ ORG 2305
Dear Sir:
The sponsorship of IND 14,963 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

Si

/

erelyJ/ours,
'
,

Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (516) 246-2413

StonYBIOOk

October 1 8,

19 82

Paul Leber, MD.
Division of Neuropharmacoiogical Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 16,111

-' GK-78

Dear Sir:
The sponsorship of IND 16,111 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.
-

S/i

cerely yours,

Max Fink, MD.
Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
(516) 246.2413

1b

StonyBrook

October 18,

1982‘

Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref: IND 16,195 -.- ORG 2408
Dear Sir:
The sponsorship of IND 16,195 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

j

/”
SiZerely

ours ,
-

Max Fink, MD.
Professor of Psychiatry

�StonyBrook

Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone; (516)2462413

,

October l8,

19 82

Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 16,905 -‘- ORG 6582
Dear Sir:
The sponsorship of IND 16,905 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

rely

yours,
:4
3,914.4;
//Z
Sin

Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and BehavioralScience
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (516) 246-2413

StOHYBm0k

October 18, 1982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6( Drug Administration
5600 Fishers Lane
Rockville, Maryland 20857

Ref: IND 16,906

-

DGAVP

Dear Sir:
The sponsorship of IND 16,906 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this
informed of this transfer.

1ND

are being

Sinc ely yours,

M

Max Fink, MD.

Professor of Psychiatry

�Department of Psychiatry and Behavioral Science
State University of New York at Stony Brook.
Stony Brook, NY 11794
telephone: (516) 2462413

StonyBrook

October 18, 1982
Paul Leber, MD.
Division of Neuropharmacological Products
Food 6: Drug Administration
5600 Fishers Lane
Rockville, Maryland 20 857

Ref: IND 17,365 -.Mianserin
Dear Sir:
The sponsorship of 1ND 17,365 is transferred to the Pharmaceutical
Research Institute of Worthington, Ohio, effective this date.

Other investigators studying this compound under this IND are being
informed of this transfer.

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

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                    <text>.
A.

“—7“.._..

May it, 1985
v—w...___W—w~—W~—.mwmewp

Barry Lebowitz, Ph.D.
National institute of Mental Health
Parklawn Building, Room llC-OB5600 Fishers Lane
Rockville, MD 20857
Dear Dr. Lebowitz,
i am writing with regard to the application for support of studies of
convulsive therapy (ECT) in the elderly, submitted by Dr. Barry 5. Pogel of the
Rhode island Hospital.

Dr. Fogel has consulted with me regarding his research program, and has
asked that 1 continue to act as a consultant, to respond to his requests for advice
and to meet with him up to four times each year to review the progress in his
studies. 1 am pleased to accept his invitation, and agree to work with him during
the study period.
’

i am particularly pleased to encourage these studies. In 1981, i
particpated in a symposium organized by Ed Faun on problems of psychiatric
treatments in the elderly. in reviewing the literature, 1 was impressed by how much
work needed to be done.‘P The studies proposed by Dr. Fogel are clearly needed.

Sincerely yours,
Max Fink, Md).

Professor of Psychiatry
*Fink, M. ECT in the elderly. in: C. Eisdorferand W. E. Faun (Eds.): Treatment 91
Psychopathology it; the Aging. Springer Publishing Co., New York, Chap. 7, 97111, 1982.

K’

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                    <text>Septanbar 22, 1969
Dr. Holmnt Laehnat
Barbiaon Plaza ﬂotal
Dear Ralmut,

It will be a pleasure to have you visit my laboratoriaa
during your forthcoming v1.1: to Nav York. Plaasa call my attic.
after you arrive and I will plan tha beat schodula for you.
212~369~7900,
SIG-£66~3158

Fifth

ext.

at 5 gas: 102 Street, cornat of
floor, Econ 42.

Hy

laboratory

H7

beat regards.

Avanua; on the 8th

245. 246 ~ officﬂ
* honn

1a

Sincerely yours.
”lax Fink, M.D.

Proteaao: of Paychiatry

all

�</text>
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                    <text>March 21, 1970

Prof.

H. Lechner
Graz, Austria

Dear Helmut,

IBM

is

have programs for period analysis, power
spectrum, and amplitude analysis, as well as aleep programs.
Difforeut methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
We

work.

Ev

am

sending you some reprints of our

beat regards.

sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

33',

gr

\

Separately I

If I have the Opportunity to spend some time
in Europe, I will surely try to visit Graz~~ hopefully to
try sailplaning with an expert.

:.

z

it

methods.

rmrvwaawu—avmw

.4

Our method of EEG analysis is based on an
1800 system, which was put together in 1965. For 1970,
too expensive and I would not suggest you try to use our

..

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                    <text>March 21, 1970
.A

‘
WW

‘w—Ww‘

Prof.

H. Lechner

Graz, Austria

-

Dear Helmut,

IBM

is

Our method of EEG analysis is based on an
1800 system, which was put together in 1966. For 1970,
too expensive and I would not suggest you try to use our

methods.

we

have programs

for period analysis,

power

spectrum, and amplitude analysis. as well as sleep programs.
Different methods are useful for different problems, and
I would be glad to advise you if you will describe the problem
for which you wish to quantify the EEG.
work.

Separately I

am

sending you some reprints of our

..
..

m

1-—.

...¢..,..,.,.,.,w.-Vw,

If I

have the opportunity to spend some time

in Europe, I will surely try to

try sailplaning with

an

expert.

visit Graz-- hopefully to

y.“

“y

My

best regards.

.

..~.-.—'r.-._..

‘~'wvv"n

mm-

Sincerely yours,

.m',--w“‘

mmM—m.

Wm'ycrw‘Tﬂw-‘ﬁ-ﬁ'l—‘mn'mw

:Rﬂ.‘r"‘:w

~

ro-mw—wn—u

.v—q:«.muw-«pwy-mewwaxwrap-1w

uwvw-w—w-

it

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 3, 1970
Dear Helmut,
have
Iand

discussed your questions about EEG analysis with
with Itil, and suggest that the best methods for
my associates
your applications are still the frequency analyses using the filter
techniques available in Europe. These techniques, as provided in
the analyzers made by Kaiser in Denmark or the fixed filter units
available from England will db the job very well, at much less expense
than any of the computer methods. As I understand your problem, it
is to measure the EEG changes under different conditions of‘cerebral
dysfunctoin, and for this a frequency analyzer is ideal; particularly
since you will be able to compare the differences between electrodes
pairs on two sides of the head. Our focus in computer methods is
largely because we are assessing the methods for special problems
in which the changes are small and we have to depend on changes from
session to session or after a drug.
The equipment has been used by the Czechoslovak group
working in Prague with good results, and they have had the Kaiser system

for

many

years.

Good luck I

thank you fbr your kind invitation to visit. I will be
at the CINP in Prague this August, but my present schedule is complicated
by the desire of'my family to visit some of the sights in Greece and
Turkey, where I have projects. I do not think it will be possible

I

to visit Gras with them this trip, but I will be in Europe again this
year, and will make a trip to Gras, not only to visit your laboratory
but to try gliding as well.
,

It

was good

My

best regards.

answered your questions.

to have you

visit,

and

I trust that I

Sincerely yours,
Max

Fink,

M.D.

have

�</text>
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                    <text>DEPARTHEIT

0!

EXPERIHENTAL PSYCHIATRY

August 3, 1962

A. Rueeell Lee, H.D.
The Tavietook Clinic
2 Beaumont

London,

street

v.1, England

Dear knee,

in London from September 9th through the
12th and am staying at the Carlton Towers. I: you are in
London during that tine please drop no a note there. I
would love to get together with you and learn aora or the

I plan to

be

goeeip or England.

that I

an leaving New York
In conjunction
West.
and following Greeley'e advice to go
with Waehington Univoreity, I an establishing a research
By new you may

have heard

center similar to P.I. in St. Louis.
Hy beat regards.
Sincerely yours,

Hrsdte

ax

n ,

.‘.

�</text>
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                    <text>May

18, 1960.

A. Russell L00, H.D.,
1h Holmdalo Rosa.

Landon, N.w. 6,
England.

Dear Russ:
VI

should like very much to

June 30, and

shall call urtor

wa

visit

with you on

arrive in

Londen.

I ctn very well.imagin¢ the problems of Macy’s
far your efforts. I had met
Sir Aubrey Lewis in Atlantic City and discussed the
iosuib111ty a! visiting hi: heapital with him. I shall
writ. to him dircctly.
and Gimbel's, but thanks

my

boat rogurdl.

Sinatraly youra,

eraa

�</text>
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                    <text>April
Dr. A.
68

25 5

196° .

Russell Lee,

Greencroft

Hampstead,

Gardana,

London, H.W, 6, England.

Dear Russ:

I wrote regarding the possibility
My present plans
my being in Europe this summer
and
I to ha in London during
pravide tcr my u;33. Martha,
28
from
Juno
to July 2 I abould
tha five day period
much
be
to
able
to
spend an even: mg with you
like very
and would be pleased if you would set asida some time
during these days.
While I have a strong aversian to mixing business
and pleasure, I beliovc I would liku to visit tho Mandalay.
I knav or no on. thore diroctly, ind bcfore asking some
of my friends from Englund who are new hora, I wandur it
you arc su££iciently acqutintcd with tbs staff to bu able
ta help an arrange a short visit?
of

\

Some months ago

last littor.

china; in tho hoapiul
I huntud at hav. continued at a rupid rat. I
think whan yau roturn to tho Stntos, 8 visit to Hillside
should muko you proud to be tn tlumnua
My best rugnrdu.

which

Since

my

the:

Sincoroly yearn,

Eu fink,
uraan

21.15.

�</text>
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                    <text>December 23, 1959.

Dr. A. Rueaell Lee,
68

Greeneroft Gardens,

Hampetead,
London,

England.

HAY.

'

g

6,

Dear Ruse:

I was very grateful for your kind letter and
invitation ea well as reprinte. Hex and Bob thank you
for your consideration. We were pleaeed to read of your
opportunity. We know if no finer institution for psychoanalytic etudiee than Tavietook Institute and congratulate
you on taking advantage of what pronieee to be a fine

educational experience.
Back here, there have been many changes. Dr. Robbins
has taken over and hie positive approach ie apparent to
Do you recall the aany probleae in moving patients
all.
from the ward to the cottages and occasionally back again?
In June Hort Waehepreee and my staff convinced Lew to create‘
a noonovenent ward in Lee I. Patients have been adaitted
unit and have remained there for their
directly to this This
has worked out well and effective
hoapital etay.
December first the hoepital ie divided in eectione, each
of which is a living space for patiente during their total
hoepital stay. Alec, the hectic matter of adminsione and
waiting liete is being modified, an that at preeent there
in no waiting liet.
In our

own

program,

we

have completed our convulsive

therapy etudiee. We are now involved in a doubleublind
fixed dosage schedule multiple drug evaluation program.
This program has had a significant impact on everybody etatﬂ and patienta alike. So far, a few patiente have
completed the initial study period and we are very enthuen
iaetio. With luck, we should be able to say eouething
intelligent about pharaacotherapy in 1962.

�Dr. A. Russell Lee (Gentd)

#2

is leaving to work
pattern is about the eeme although, with the third your
training program appravel in site I envieege some changes
in attitude including a greater interest in fellowships.

with

By

You may know

that

Bob Kehn

Perlin in Hontetiore. Otherwise our stuffing

I plan to be in Beale in July and, tine permitting,
I should like very much to visit Tavieteck Clinic and also
the Mandalay. I shell write to yet beforehand it I can

make

arrangemente.
Hy

beet wishes for the

Rev

tear.

Sincerely yours,

HFIJB

�</text>
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                    <text>ww—w-r ~‘nm'.

-Wm

wa—z—vnqmr

July 25,

19 87

Dr. Stanley Lee

Box 12A

Department of Psychiatry
Downstate Medical Center

Brooklyn, New York 11203
Dear Dr. Lee,

am pleased to support the appointment of Dr. Thomas Craig as Professor
of Psychiatry in your Department. [have known of Tom‘s work for many years, and
have worked with him at Stony Brook from 1983 to his leaving earlier this year.
1

At Stony Brook, he has been responsible for the residency training program,
the ambulatory care services, and the acting clinical director for the in-patient
service at University Hospital. He has been an active administrative officer, as
chairman or member of numerous departmental and medical school committees.
he has also
While he has carried these burdens -- and he has carried them well
maintained his research projects and continued to present and publish the results of
his studies.

-

Tom is an excellent researcher with special skills in epidemiology and
in psychotherapy and psychopharmacology. And, he is a fine administrator, with skills in organization and in
interpersonal relations. He is an excellent supervisor and a superb consultant. He is
well liked by the residents and the staff. Indeed, since he has announced that he is

statistics. He is a fine clinician, with skills

leaving, there has been general consternation among the faculty, the nursing staff,
and the residents.
We were sorry to see him leave. I heartily endorse his appointment as

professor of psychiatry.

Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>November 7, 1978

Alice Leeds,

M.D.

PRB- NIMH

5600 Fishers Lane
Rockville, Maryland
Dear

20857

Alice,

I have read the latest issue of the Psychopharmacology Bulletin,
and following your ibvitation on page 3, I am writing to suggest some
additional

titles for

the Recurrent Bibliography.

(Electroencephalography): I sought this item since the
effects sf psychoactive drugs are clearly defined in EEG measures. At
but when I
first I thought there were no such articles to be indexed,
found three among the citations that would clearly be so indexed, I
assumed the class was not in the master index file.
EEG

Convulsive therapy (ECT; Electroshock therapy): It is fairly
clear that the effects of ECT are operative through biochemical mechanisms
that are similar to those which are invoked as explanations for the effects
of antidepressant drugs. The index includes reference to ECS, the animal
equivalent of ECT when doen properly, but not to ECT.
Other items of

interest that

Mianaerin

seem

lacking are:

(GB—9h)

pharmaeokinetics, drug
pharmacodynamics, drug
plasma (blood) levels

I trust these

comments

are of

some

use;

My

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

�</text>
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                    <text>March 9, 1970

Dr. Alice A. Lead:
Chief International Belerence Center

for Information

on

Psychotropic Drugs

Psychophermacology Research Branch
National Institute of Neural Health
5654 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Alice,

Following your suggeetion, Dr. Shapiro and I have edited
of our program review for the "Paychepharaecology
Bulletin”, and we trust it meets your standards. We would be
pleased to have the summary included in a review of ongoing
psychaphermagology programs.

the

summary

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="106594">
                    <text>7383—3331

deruuny 15th,

1973

Alien A. Lucas, M:D..
Chief, International Retoronce center,
Psychopharuncology Rnloarch Brunoh,
Hstional Institute of Mantnl Health.
5660 Fishers L330.

Roekrillo. Hhrylaad

20852.

Dear Alieo,

nude

Ehclotod are two summaries of preaentnticno

at tha

matina

ABHP.

Khan next yen

for incluaian in the

that I

Payehopbnrmncology

are in the
I leak tbrvurd to seeing yuu. east. acne

and

visit us.

sincerely yours.

th Fink. M.D.

Praftlaer of Psychiagry
NP/iJ

WI;

�</text>
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                    <text>may 31, 197h

Turan

Itil,

M.

38 Godwin Lane

D.

Ladue, Missouri

6312h

Dear Turan:

Enclosed is a coPy of a report which I gave at the
Meeting. as well as the new paper from Lancet which may
interest you.

ECDEU

Should you have another copy of your

appreciate reading

it.

TRH,

I

would

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

Enclosures

�</text>
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                    <text>uv-wrwv-w'

"w,

w—;~

6/29““

..._

.
.___

wrewwlw

.
.7.

i.

m’w‘r'w‘-v-&lt;

A

u.

~mnwwwlwrwrmmm

Abraham

Sudiloveky,

Clinical Research

Squibb

—

M. D.
CNS Team

Institute for Medical Research

Princeton.

J.

H.

085h0

Deer Abe:

(a,

smzmwv‘r

._

r—wn

'u«v¢

—-

:4
a

wj-v—wwrww—mrmmrvwmwvw,mmmuw-m—c

In discussions in Princeton with Dr. B. EtLr, which in~
cidentally I enjoyed very much, reference was mud to studies of
the peptides by scientists at Squibb using material obtained from

I have checked my references. and find a few publice—
1965
with deWied and two others with Upton and Lerner.
tiona
These seem to add
to our information on the central effects
S. Lande.
—-

little

of peptides.

enclosing a report I yrepered for the 197h ECDEU
meetings. I
grateful for any citations to published or
which
may augment this summery and my impressions
unpublished data
of the merit of these atuﬂies.‘ I.em particularly interested in the
studies at Squibb which were cited. and which may be in the public
domain. Would you care-to check with him and with Dr. Clody?

I

em

would be

many

thanks aha

my

best regards.
Sincerely yours,
Mex

Merd

Enclosure

Fink.

M.

D.r‘

Professor of Paychiatry
:‘

�</text>
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                    <text>November 22 , 1966

Dr. Jay Defer
510 East 86th Street
New York, New York 10028
Dear Jay,

a small world and your letter to the Administrator
of the Department of Psychiatry was referred to me for reply.

It is
I

am

pleased that you are interested in coming back to

academic medicine, and
of interest to you.

I think there

may be some

Unfortunately , your curriculum vitae

opportunities

is misplaced

within

I
request that you send me another.
a large file
Would you call my office for an appointment and arrange to
see me at your convenience?
and

would

I look forward to renewing our acquaintance.
Sincerer yours ,
Fink, M.D.
Professor of Psychiau'y

Max

Mszp

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                    <text>.,W,

“y“-..

,v

May

v—,,

.

15, 1967

n
V,_

_

«WWW-«rrn'ww‘

.u,

Dr.

Issai lcfhowitz

Claxksville Road
Princeton Junction,

New

Jersey

V.

”WI-‘.VK~.W;..&lt;

Dear Dr. Lefkmitz:
Within a week of the time that we discussed your interest
in magnetism, the enclosed article appeared in the New York Times
(May 6). Apparently Dr. Cohen has built the room you suggested.

Iantakmgthelibertyofsendingyouoopies ofthetwoarticles

and wonder

if you could

answer a question

for me.

The electrical activity of the brain as recorded on the
surface of the scalp is generally calibrated as varying between
50 «and 150 microvolts in amplitude for leads which am approximately
one centimeter across on their surface and separated over the
scalp from two to five inches. Can Dr. Cohen's laboratory measure
the changes in electrical activity from the brain.

Perhaps we

will

have an opportunity

to continue our discussion.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
“,1...“

«u

«rs-u:

w—v

A

vqua-m,

.

.

�</text>
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                    <text>June 11, 1966

Dr. Rain: 3. Lohmnnn

Clinical Director

Verdun Protestant Hospital
6875 LaSallo Blvd.
Verdun. Quebec, Canada
Door Reins:

for the manuscript:
I found then quit. incoroottng,

Thank you vary ouch

drugo.

on the Butyrophooone
and I on planning to

carry out observntions which should confirm your psychology
and EEG observations with trifluperidol.

Hy

best regards.
Sincerely yours,
Fink,
Director

Max

ur/jb

M. D.

�</text>
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3W
SBYH'12SSB
May

Bruce Richman,

10, l97h

M. D.

Department of Psychiatry

Duke

University of Psychiatry

Durham, North Carolina

27710

Dear Bruce:

pleased that Dr.

I cannot

you
tell
Faun

how

Our move

to Stony

Brook has been

delighted I

am

that

you have been so

has invited you to go to Houston. I do not
know the kind of work that will come from Houston, but for many years,
I have known of studies undertaken by Dr. Heil Burch and the Houston
State Psychiatric Institute. His work is outstanding in quantita~
tive EEG and you may wish to visit him once you are in that City.

audiessful.

The

laboratory

is running well and Peter, Ira and Maureen are the mainstays of the
lab. We are very interested in the relation of EEG to blood level
of drugs and hope to make acme contribution through this effort. The
studies run well and our principal difficulty now lies in the statistics rather than the data collection.
Should you find yourself in the east, come and visit; and
should you find the heat and the reactionary thinking of Telas too
much for you, come back to work in the heady free climate of the
eastern seaboard. Whenever someone tells me he is going to the miduest or the south, images of my feur years in St. Louis thrust them—
selves into my consciousness, and I am reminded again and again of
the stubborn, reactionary and preJudiced attitudes of the community,
in which I worked. This attitude was not limited to the locals, but

included the professionals at the University as well.
Again,

let

me

congratulate you on your progress and wish you

success in getting your doctorate soon.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

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                    <text>.

r-w-wmpuw;

Vlin‘friﬂh'lﬁﬂ“~&gt;"N‘|L|"4‘

.V

nn-a,‘

wwvsaqumy,

.

..

'

:'

A,

V

.

July 12,

‘

rm»
mrtw'wf‘vm'nx—w.

wax-“nun.

r w. wo~.'('1"'1\ man 7 . a”. -.

1967

Dr. H. E. Ielmann

memtiw Director

Dmuglas Hospital
6875 LaSalle Blvd.

Verdun, Quebec

Camden

Dear Heinz,
Enclosed is a mpy of my discussion at the thioxanthene
converence. I hepe this is suitable. It does represent my

opinion regarding the value of this physiological variable.
My

best regards.

Simmly yams , '
Fink, NJ).
Professor of Psychiatry

Max
MI-‘zkp
a

v'ﬂmwsm

.

an»,

up“ ‘0“. .1 u

.m.

-

.~

,__‘

~-.-,-.- .

�</text>
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                    <text>November 9 , 196”

Dr. Heinz Lehmann

Clinical Director

Verdun Protestant Hospital
5875 LaSalle Blvd.,
Verdun, Quebec

Dear Heinz:
Thank you very much for sending us the
reference to Ziolko. I have requested our library
to obtain a copy of this article and look forward to

reading

it.

Enclosed are four reports which relate to
the problem of individual differences in response to
pharmacol therapy. The off-print regarding carbined
chlorpmnazine~procyclidine in depressive disorders has
been accepted by Jonathan for psychopharmcologia.

In addition to these references , I am including
a reprint of a paper entitled " Psychological Factors
Affecting Individual Differences in Behavioral Response
to Convulsive Therapy" . The principles discussed in this
paper, I believe, are just as tme for psychotropic drugs,
although we have not done as extensive a study program for
drugs as we did

for

ECI‘.

Also, there is a report by my former associate,
in Psychopharuecologia V: 397,19614. In
this article he describes two types of anxiety syndromes
and has carried our typological assessnents further than in
the reports which we worked on together.
Donald F. Klein

A

I

hope

that

Dick Wittenborn and Jonathan are
symposium pub-

successful in having the reports of this
lished.

Sincemly yours,
mf/ ls
e nclosures

Max

Pink,

Director

M.D.

_

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                    <text>Mitch 8, 1965

Dr. Raina Lab-Inn

Clini¢:1 Directar

-

R

Verdun Protastlnt Hospital
6875 LaSnllu Blvd.

KWMm.wwu
Duct Raina:

I want to can this. Opportunity to thank you for your 551 Egg
consultation in Haw York. Following our luncheon. Turin 1:11 and
I discussed the roeouanndations and: by yourself and Jonathan. We
found ch: Iugsuottanl eonotstaut with your own ideas, and have
incorporated than in our prnlant draft propoaal which will be submittad
to ch. noxt Inctinx of the Clinical Committee.
Many

thanks.

I look forwnrd to seeing

you

at ch: and of Hatch.

Stncarcly yours,

Ht: Fink,
Hrzju

H.D.

Professor of Psychiatry

.

�</text>
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m. Heinz

1965

Lahmmn

Bummtive Director

meec Peychophermeologieal Research

1025 Pine Avenue
West Montreal, Quebec
Canada

Assn.

Deer Heinz:

Mywvezymdx foreemingmeeepyofyourmview
oftrimpmrine. Aslhednemledgeofthie mumdbefom
I received the when, I read the text with a great deal of
interest. ‘Ihe museum
that I meeived is that this comma
is less of an mtidepmsemt men imiprwmine, but may be useful

W

in

who do not nepend because the anxiety
Waive disorders
to be unumally large

mum

I wmld like to mngmnnete you and your associates for
having undertaken the task of reviewing new mpomds in m
independent fashion in e style reminiscent of our emfemms
of the late 1950' s, mien were so helpful in disseminating the
latest information regarding new
Hwy thanks, and

my

W.

best regards.

Sincerely yours,
ﬂax Firic, PhD.

Professor of Psychiatry

�</text>
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                    <text>July 18, 1965

NJ).
Wm,
Clinical Dimctor

Heinz E.

Verdun Protestant Hospital
6875 LaSallc Blvd.
Verdun, Quebec

Dear Heinz:

delighted to road of your symposia on adverse drug
reactions, for I have just written a. letter to [so Hamster
to wk his commute regarding a problem which we have recently
observed here. I am taking the liberty of sending you a copy
for your opinion as well. Is this phemmana of "water intoxica—
tion" or ”paydxogenic diabetes insipidus" described in your

I

was

promedings as an adverse mactim to psychotropic drugs?
The syndrouo us have obscmd appears related to the phenomena
of dmgdnduoad parkinsmism.
‘

I from that the Quebec Psychophanmoological Rescard'l
Association will continue its good work and look forward to
the synposia as they are produced.
My

best personal regards.
Sincerely

yam ,

Firdc, NJ).
Professor of PSychiatry

Mm:

Wm?

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                    <text>Ear-Oh

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                    <text>May

Dr. Heinz E.

Clinieel

31, 1966

W

Dimm

Dmglea Hospital
6875

Walla

Verdm, Quebec

DeerPhinz,

Smmkaegoywmkimwmmempyofm

Wmmvmehymgawetmcmi’inumhm
m.Alfmdﬂ.Pmemn. khhasmfu‘mdthismpcrttom,end
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My

new

Wt

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New

York medical College

New

York,

Firm Amaze at 106th Street

At

this Center, I

the clinical

York 10029

:38me
mm.
m

and which have
Hy

New

thﬂt I will be able to m~establiah
which ngen in New York,
prom
an well in
Imps:

best regards.

SW13; yours,
Fink, 2m.
Professor of Psychiatry

Mex

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vrv-r’V'WK"

May

18, 1967

In". Reina E. 1311mm

Clinical Dimctor
Dwglas Hmpital

6875 LaSalle Blvd.
Verdun, Quebec

Canada

DaarDr. balsam:

for yaw invitation to join the Q.P.R.A. mating
I will try to arrive mud 12:30.
Incidentally, m MW: recently purliahad our
withthiothixmandmﬁdhepleasedtodiscumthepapem
being pmnented fun the vimpoint 01' that axperim. Thank
you for the invitation.
Thank you

on June 21.

mime

My

best mgmds.
Shmamly
Max

Fink,

yam ,
14.1).

Professom of Psyctdatry

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"H,

u.

:wn-wﬁ’r'WW-JJVIAJ'I- ‘4“ it?"

w

'iiﬂY'rWN'mWﬂW‘K\.u~wn'

-\.,,.~u-m.‘,~&lt;:r—mum-v map-a7.— ew‘

."v- A-‘dw‘ﬂl""'(.

...u~wgu m. w-u.~...r—w-moron» -';--F's&lt; mm 1;

Ont-".7

.—-\
wo'wt-ﬁrq'pvmrw'

inhuman.

,rv-

September 8, l967
Dr. Heinz E. Lehmann

Clinical Director

Douglas Hospital
6875 Lasalle Blvd.v
Verdun, Quebec
Canada
Dear Heinz,

'.»'Y“',

w-

rm

n‘3“

.stwiw-r-c'mrmmnl‘vmmynt

n
an

mm

w-n:

h":€-I«KW

I am grateful for your kind reception of the suggestion
that cyclazocine be discussed at the antidepressant panel. The
provisional title is "EEG Patterns Relating to Clinical Anti~
depressant Activity."
I would plan to review the EEG profiles of the known antidepressant drugs, describe the profile of cyclazocine and then
give an up-to—date report of the clinical studies of cyclazocine

as an antidepressant.
I

will try to

as requested.
My

have a copy of the paper to Dr. Hittenborn

best regards.
Sincerely yours,
Fink, M.D.
ProfesSor of Psychiatry

Max

HF :

kp

a!

a‘ “v.

.--~r—.

.4l.""

,—«~ ~

.

.m-

—.

hm

.1

-

l,

nu,

�</text>
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                    <text>January 10. 1968
Dr. Heinz E. Lehmunn

Clinical Director

Douglas Hospital
6875 Lasalle Blvd.
Verdun, Quebec
Canada
Dear Heinz.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York MedicallCollege on May 3l.
The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the 15th floor at 11:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychological Tests
and Drug Effects.“
We

I

will defray your expenses and there will be an honorarium.
will call you before Hey 3l. Thank you for accepting

our invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>August 19, 1968
Dr. Heinz E. Lehmann

Ciinicai Director

Dougias Hospitai
6875 Lasaiie Blvd.
Verdun. Quebec,
Canada
Dear Heinz,

It

has taken many years to deveiop a asabie EEG predictor
for novei psychoactive drugs. The enciosed reports of
cyciazocine as an antidepressant have been submitted for
pubiication. Knowing of your intereSt and enthusiasm for new
drug evaiuations, perhaps these experiences may suggest simiiar
experiments with other novei compounds.

model

My

best regards.
Sincerely yours,
Max

Fink, M.B.

Professor of Psychiatry

�</text>
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                    <text>/

Form 91.28 Adm.

11wa

State of New York
Department of Mental Hygiene

LONG ISLAND RESEARCH INSTITUTE
State University of New York at Stony Brook
Health Sciences Center IOT
Stony Brook, New York 11794
STANLEY F. YOLLES. M.D.

.

DIVISION OF CLINICAL SCIENCES
MAX FINK. M.D.. DIRECTOR

M.P.H.. F.A.C.P.

INSTITUTE DIRECTOR

(516) 444-2447

(516) 444-2163

April 2, l980
Dr. Heinz Lehmann

Associate Director for Research
Office of Mental Health
hh Holland Avenue
Albany, NY 12229

Dear Heinz,
The tragic death of a patient undergoing ECT at Manhattan State HoSpital
month should be a stimulus to an improvement in ECT practice at MSH and
at other state hospitals. Some time ago, in October, in response to an
OMH
request for suggestions for "technology transfer", I submitted a
proposal for ECT training and monitoring. (I sent it to R. Whalen and
s. F. Yolles at LIRI. )

last

No response has been forthcoming, and of
course, such is not unusual.
However, one element of that recommendation was an invitation for ECT
therapists and nurses to attend an ECT.training session. Three are
scheduled —— in Chicago on April
at Stony Brook on April 25, and at the
APA Meeting in San Francisco in May.

ll,

I enclose copies of the Stony Brook program. Perhaps you will wish to
take credit for the application of some LIRI research to improve state
hospital services, by recommending, to the appropriate officers at OMH, that
designated users of ECT attend the session at Stony Brook.
I trust there will be an Opportunity for you to
’
regards.

visit

us soon.

.

Sincerely yours,
Max Wink, M.D.

Professor of Psychiatry
MF:sl

Encs.

My

best

�</text>
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                    <text>”xv-’1
s.

i.

w..-

.

v

«V.

”WW”.

..,

.

.
..

,-_

a...

....

,5.

a

a

.

«3-...

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.w

«aw—m»

«mm

m

4-

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une-

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urn—"mm" ﬂm-W‘

Wr—

V

run-.nrmv—m

.Ir-v-‘v'V'm—v—nvu—

‘m*r"ﬁnWI—v‘wcw-W

August 18, 1985
John Lehmann, Ph.D.
Department of Neuroscience

Ciba-Geigy Corporation
Summit, New Jersey 07901
Dear Dr. Lehmann,

This letter is in response to your inquiry regarding the availability of a
post-doctoral candidate in EEG to develop spectral analyses for drug effects in
animals. i regret that i have no candidate to recommend from my laboratory.
If you are willing to import an overseas scientist, you may wish to write to
Dr. Walter Sannita (Laboratory of Neurophysiology, Osp. San Martino, v. ie
Benedetto XV, 1-16132 Genoa, Italy). I understand that he has a number of
associates, one of whom may be interested in a two year opportunity in the U.S.
.

Also, the best man from my laboratory in the past decade has been Mr.
Peter Irwin (201-386 8683). He is an excellent scientist and understands drug
effects, frequency analysis, and EEG very well. A few years ago, he left to work in
Sandoz in Basie with Dr. M. Matecjek (who heads the Sandoz quantitative EEG
laboratory). After a few years, he wished to return to the U.S., but Sandoz had no
EEG laboratory here, so he has been working in clinical pharmacology. if you are
truly seeking for 'the right candidate to be the driving force and run the project'
you may consider him. His salary may be a problem, as he left us at more than
$#0,000/year (and well worth it).
Finally, there is a new organization, recently formed in Europe to bring
scientists interested in drug effects and EEG together. Meetings are held every two
the next will be in Genoa in July, l986. The IPEG - (International
years
Pharmaco-EEG Group) includes both clinical and animal pharmacologists, and drug
effects in animals and man are discussed. You may wish to write to the President
of the group, Dr. Johann Kugler (Nussbaumstrasse 7, D-SOOO Munich 2, Germany)
for further information.

-

w

~mv'—

Good luck.

vw—

-.-

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WWw-w

m

mﬂww-

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

'

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    <fileContainer>
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                    <text>.

mvmW-m

'w'n-v'H'v-w‘u-I-I

November

4, l978

my.”

rm

Dear Dr. Lehr.

,«
..

"v

Wm

v—v—a—u

V;'Wm"‘

-

Wwvv‘Wi

believe the next steps in regard to the prepriety of obtaining
support for research from the Central Intelligence Agency is to request
Dr. Hasserman to withdraw this application. Failing that, it is advisable
to obtain the opinion of the Faculty Senate.
I

-

write-4"»

r'r‘pw-WT—v

funds.

3. Regardless of the financial needs of the investigator. the
Chairman of the Department of Pediatrics exercised poor Judgment in
insisting upon an immediate recommendation. By not allowing the usual
processes of decision to take place, he precipitated an issue which is
divisive. The same results probably face the College as soon as the
public (i.e.. the Faculty, the students. and the community at large)
become aware of such a request. whether or not
is funded.

it

.

For these reasons. I recommend that the whole faculty have an
opportunity to participate in the Judgment, thereby accepting responsibility
for the conflicts that may ensue. The approved motion and the sense of the
discussion may be sent to the Dean with a request that the problem be
placed on the agenda of the next meeting of the Senate.

a

.r-arvv

“Fm"n-ﬁlv'r

~

sees this issue as a sensitive one, and
appears evenly divided as to the prepriety of the College accepting such
The Research Committee

2. The Chairman of the Department of Pediatrics acted as if the
issue was a sensitive one and obtained prior permission from the Trustees.
the President and the Dean - steps that are unusual.

r”-

&lt;

l.

Incidentally.

I

regret that

Dr. Nasserman and Dr. Freedman were

allowed to participate in the Committee's discussions. Because the
Chairman of the Department of Pediatrics exhibited an insensitivity to
this issue it may be advisable for the Chairman of the Research Committee
to share the Committee's discussion with Dr. Hainstein, who, I fear, may
be under misapprehensions regarding the basis for the decision of the
Committee (notably. his awareness that some members of the Psychiatry
and Neurology Departments do not share his scientific views). It would
be regretted if Dr. Nasserman's misjudgment of motives were to color
his reports to Dr. Neinstein, and that the Research Committee be considered
as infringing on Dr. Heinstein's academic freedoms.
Many

thanks; and

I

trust these

comments

are helpful.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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            <name>Date</name>
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            <elementTextContainer>
              <elementText elementTextId="36711">
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              <elementText elementTextId="36712">
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            <name>Source</name>
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              <elementText elementTextId="36713">
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                  <elementText elementTextId="103195">
                    <text>,.

v.,-

wq‘mr

.

,

WM

.-

an.»

V

m.,—ywru.m n.1—WW‘
,

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January 16,

7......m—m .,.,

1970

Dr . David Lohr

Dcpartmont of Pharmacology
Now
New

York Medical College
York, New York

Dear Dr. Lehr:
While I very much enjoy

my

membership on the Resourch

Committce, I find it difficult to attend tho scheduled
meetings with sufficient regularity to be an active
participant. In discussing this problem with Dr. Freedman.
I suggested, and he concurrod in asking you to appoint an
alternate from our Bapartmont.
We would recommend Dr. Arthur Zaks as alternate to the
Committee on Human Research; and Dr. Richard Abrams. to the
parent committee. If you agree, I will continue to attend
whenever possible, asking the alternates to accompany me when
they can, and to replace me when I cannot.

If this

recommendation

for altornate suggostions.

is unacceptable,

I would be

Sincerely yours.

Professor of Psychiatry
MF:kp

grateful

�</text>
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                    <text>-.:

.

"WV:

wawurm

Ma!

r- 1W &gt;c‘

u.

_

w," swung.” ‘m.,.,,&gt;£__.,.,_,.,,...,u_..V“_F:ﬂ.

,_

we,

&gt;

.-

M.

~q-. 7..

»_

.wwmwm..wv_s,rm-h

,.

~..

.)"-u~--

«v.,:

wxe- vIILW'ﬂ‘.-vv~,lv-.-"" 1‘1.-&lt;-‘r"'rH-rra-.mw-..v,mn.v-

«any

-.....

7..-»...w

._...._

,,.__,_

November

"‘5'

.rr

6, 1970

Dr. David Lehr, Chairman
Research Committee
New York Medical College
New York, New York
Dear David,
The study "Anticholinergic Drugs, Convulsive Therapy and
Man" was approved September 23,
1968, and initial work was performed by Dr. Robert Levine. The

Alterations in Brain Function in

attached protocol "Multiple Monitored Electroconvulsive Therapy"
is submitted as an amendment of that project. The essential
differences from the previous protocol are:

mmmvwW-n

May

1.

Administration of electroconvulsive therapy
multiple treatments each session.

2.

Addition of newer

3.

Addition of behavioral ratings (Hamilton
Rating Scale for Depression, Beckomberga
Rating Scale for Schizophrenia)

4.

puncture for assessment of
biochemical changes after ECT.

5.

Deletion of syntactic analyses, administration
of anticholinergic compounds.

memory

Lumbar

tasks.

CNS

I request this continuation be filed as an

that project?

Thank you.

amendment

Sincerely yours,

A
V

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

of

�</text>
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                    <text>A

,
.
A.»

.

deruary 16th,

2..

._,..

1973

.

,

.

1.,

4‘,

.

33,2

,.
.,

5.43,.»

Dr. Duvid Lchr,
anartaent of Pharmacology,
Haw York Medical Collage,
106th St. and 5th kvanun,
KW York, ELY. 10029.

57-1..

um

wac-

wu-uv-r.

r

navy.

ﬁscawesm-

wasvm'bﬁwm:

Dear David.

I have Just reoetvea and rend the Annual Royort or the
Resourch Committee for the yariod ending June 30th, 1972.
This is an impressive docungnt and reflecto a great deal
of warn, particularly on.your part. Conaiaering the severe
anﬁbnak in funds. tha flat lawal suatainad between 1969
and 1972 1: a credit to thn faculty.
I want to thank you for making IV sarvice on the
researeh cummittae so pleasant. I take this opportunity
to extend my reuignution. as I ta now uhwout fullntinn at

my haw

venture.

While

manna-r

:"rqugzemrgs-r-

.

it has

only been a raw yuara that I have untohcd

yum work ﬁl Chairman.

I

an aware of your yuonun cf!ort.,and
usubcr of the committee I am
adriee and leadership.

both as an invastigttor tad

grttotul for yuur hslp.
my

;

boat rasnrds.

lmv':§1ry;m§‘rtgaw;wﬂz

ﬁancercly youru.
mwmn.

mans-w.

Mn: 31nk. M.D.

Kenn)?

frets-tor of Psychiatry

in'w‘

.

59n-

33/13

�</text>
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                  <elementText elementTextId="105940">
                    <text>"wamw

\\

‘gv-I-

‘w

wwwmmwvv

-

~

July 10, 1970

‘

Dr. Leah Lehrer

Consultant, Hospital Programs
City of New York
Department of Hospitals
125 Worth

New

York,

Street

New

York 10013

Dear Dr. Lehrer:

for your inquiry of 7/3/70. Enclosed are the
three protocols you requested, and I trust these are sufficiently
descriptive.
I have called our Research Administration, and Mrs. Lasker's
response is attached for your information. Perhaps Mr. Constantine
can be instructed to send the material as complete as submitted, and
Thank you

more promptly.

Sincerely yours,
;

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

encs.

�"Tu-w ' 'M-w-

V

~—-w—r~ Vwa’avw~—

u...

»»-Ar~"~wi\-

V'HDWMﬁ'Tﬂ/ﬂ'tilwuy ,«vgg-g-u-r. “-7.; vlq‘p'wﬂ

'nr‘wu' »

.imvm-‘m—~...,,...,..(&lt;.--~—.r- Wlﬁ\\_u--ﬂW-qr‘ "4...“.

July 10,

,w.........e.,,.w..,

..

‘3”.‘v‘m ”Wm".

...~

i»...

1970

Mr. John Thompson

Bristol Laboratories
Syracuse,

New

York

Dear Mr. Thompson,

For a number of years we have supported the development
digital computer analytic system for EEG analysis, using an
IBM 1800 central processor. Our programs are of two kinds-- period
analysis and power spectral density. These run in real time and our
outputs allow for a variety of statistical techniques. Our present
approach is to determine drug effects by comparing the sequence of
changes in eny variable after medication by linear regression. Our
period analytic program yields data describing changes in frequency
bands, in amplitude, and in the variability of both; as well as changes
of a

in

first derivative activity.

are able to process 1/2 inch IRIG compatible tape,
300; and will soon be able to process 1/4 inch
using an
IRIG tape. For our collaborators, we deliver either the data of the
primary analyses on cards or magnetic tape; or carry the analyses
through to the final stage using the school's IBM 360/40.
We

Ampex SP

Our recent efforts have been focussed on assessing the
numbered
novel compounds with preseumed psychoactive
profiles of
potential for industry. We would be pleased to discuss.this work

with
so

members

of your research division (although I recollect doing

last year).

Thank you for your inquiry.

Sincerely yours,

.m-unww

.

Max

Fink, M.D.

Professor of Psychiatry

mf/

v

.

.._, your”,

V,

0.. ,.
,

�</text>
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Dr. Samuel Lehman
Director, Department of Psyclﬁatxy
Long

Island Jewish Hospital

Glen Oaks,
Dear Dr.

is a

New

York

term:

It was a pleasure

copy of

my

talking to

curriculmn vitae.

you yesterday.

Enclosed

mny thanks foryour time.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

“1ka

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Dr. Samuel Lel'mnan, Director
Department of Psychiatry
Long; Island Jewish Hospital

New Hyde

Park,

New

York

Dear Sam,
Thank you very much

If it is

for the inquiries which you

made.

without special effort on your part, I would be

pleased to rejoin the

staff.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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