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                    <text>r—._——..__er-.

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7.

January 28, 197h

Prof Dr. H. Kﬁnkel
Dr. Giulisno Dolce
CHAN

3000 Hannover-Kleefeld
Germany

Dear Dre. Kﬂnkel and Dolce,

busy at work preparing the document you requested
to tell you
for the forthcoming meeting of the CEAN. I am writing
tables are
the
of
some
and
soon
as
as
text
the
have
completed
that I
I believe
be
sent
to
you.
both
will
and
the text reotyped,
prepared
5.
mid—week
February
next,
by
office
these will leave my

I

am

I trust that this slight delay will not impair the

working of the congress.

I ask that your records be changed so that future
communications be sent to my address at stony Brook, or better
yet, my private box:
May

Mex

The

address at

and messages

my

Fink,

M.D.

P.O. Box 269
Great Neck, New York 11022
U.S.A.
New
York Medical College is
the

there are delayed.

rarely used

by me

best regards.
Sincerely yours,
Fink, M.D .
Professor of Psychiatry

Max

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                    <text>Department of Psychiatry and Behavioral Science
Health Sciences Center
State University of New York at Stony Brook
Stony Brook, New York 11794-8101

StOﬂYBrOOk

telephone: (516) 444-2929

August 23, 1990

Stephen Koslow, MD. and Herman van Praag, M.D.
Chairmen, Credentials Committee
ACNP
Vanderbilt University
Nashville TN 37235
Dear Steve and Herman,
It is with great pleasure that I submit this letter in support of the
admission of HAROLD SACKEIM, Ph.D. to membership in the ACNP.
I have known Harold for about a decade, first meeting him when he
in academic research in the neuropsychology of perception. He
interest
expressed an
used ECT as a way to modify brain function, and did so intelligently. He joined Sidney
Malitz at the New York State Psychiatric Institute where he developed the nation’s
strongest research program in ECT. We have worked together on the APA Task Force
on Electroconvulsive Therapy and on the editorial board of CONVULSIVE THERAPY.

Harold is an outstanding neuropsychologist, a direct descendent
(conceptually speaking) of Joseph Zubin, Richard Wittenborn, Conan Kornetsky, and
other SOphisticated psychologists who did so much to make the ACNP a scientific
organization with holistic interests.
Harold has a detailed knowledge of neuropsychology and
electrophysiology. He is an expert in perception, memory function, anti-amnesic drugs,
cerebral physiology (cerebral blood ﬂow and SPECT, to be specific), statistics, and the
psychopathology of affective disorders. He first came to the attention of the research
community in his innovative studies of the role of facial asymmetry in the manifestation
and perception of expressed emotion. He has made important contributions to our
knowledge in ECT; specifically, in the role of the stimulus in treatment response, and on
the physiologic and memory effects of different dosages and electrode placements. The
ongoing studies of cerebral blood flow and SPECT are promising to add more
information on its mechanism of action. His clinical skills in interviewing and diagnosis
are excellent. He is friendly, warm, enthusiastic, and an extraordinarily hard worker.

�</text>
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                    <text>April

17 , 1967

Mrs. Carl S. Kosof
30 East End Avenue.
New York, New York 10028

DearMm. Kosof:
Your

me

letter to

for reply.

Dr. Robert Sharoff has been forwarded

to

the information is
request is an extensive one andthe
of
questims can
some
However,
not readily available.
Your

be answered.

All the patients admitted to the Metmpolitan Hospital
is four to
are voluntary. The average period of witlrbawal
are used.
appropriate
cmsidnred
treatments
seven days and all

'I'hetotalnwnberofaddictsatanyonetimeamfiftyamme

majority remain with us for aftercare.
There is no data available regarding the source of referral
or the percentage renaming off drugs after discharge.
Sincerely yours,‘
Pink, Md).
Professor of Psyclﬁatry

Max

MF:kp

�</text>
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                    <text>July 16, 1970
Miss Deveede Ross

c/o

New

England Medical Center

171 Harrison

Boston, Hessachusetts 02111
Dear Miss Kass:

I have reread your letter of July 2, and in the light of
your illness I would like to recommend the following.

3"
‘
-'

I have reviewed the combination of sick time, vacation
of 17 days, and overtime due you and find that your first day
of work is September 8, Tuesday, the day after Labor Day.

.

“v

Inn-:uvw"

5
1m

In the event that you decide to start your schooling I suggest
that you call my office at least a week ehedd of time.

‘3‘

'm-wmwvnu

I trust that you will be
work
to
on September 8.

V"
1‘»

7.

'/~‘M~'W1&gt;'s“m"",'h

sufficiently recovered to return
Sincerely yours,

J.»

,.,~;

,y;.-

Fink, M.D.
Professor of Psychiatry

Max

w],

.

en...”

~’
:20:

's"-'.?=

"Maintain,"

emvnr'Wv—m-Lv

~'

"-wwmmrw-vmru

Tm;

?

�</text>
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                    <text>March 10, 1971

Dr. Hans

W.

Kosterlitz

Department of Therapeutics and
Pharmacology

University of Aberdeen
University Medical Building

Foresterhill,

Scotland
Dear Dr.

Aberdeen

Kosterlitz:

Our contribution to the ”Symposium on Agonist and Antagonist
Actions of Narcotic Analgesic Drugs” in Aberdeen will be:

Clinical Studies of Cyclazocine

and Naloxone

in Treating Opiate Dependence

Max Fink, M.D.*, Alfred Freedman, M.D.,
Richard Resnick, M.D. and Arthur Zaks, M.D.

I
I

trust we will be able to obtain the funds
will write again.
The program

participating.

You

and

if we

are unsuccessful 9

is an excellent one, and we look forward to
will recommend hotel accommodations when

arrangements are made.

Again, our thanks for the

invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt
"0'"va

«an:

w

‘

cc:

Dr. Freedman

�</text>
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                    <text>April 28,
Dr. Hans

Kosterlitz

University of Aberdeen

Fosterhill, Aberdeen, Scotland

Dear Dr.

Kosterlitz,
I look forward to joining you in Aberdeen
for the invitation.

and I again thank you
w-wrw

~

:-

”WV-Fr"

‘.~

1971

we

on

July

will discuss ”Clinical Studies of Cyclazocine

Naloxone in Opiate Dependence", and the authors are, as
Drs. Mi Fink, A. M. Freedman, R. Resnick and A. Zaks.

12—13,

and

listed,

”aw-ru—

gar—wwrwm‘mrt.

"n":

m.

A

I plan to bring my wife to Europe as well as my two
daughters, ages 13 and 15. If accommodations can be made at the
Hall of Residence, I would appreciate two rooms; if not, would
you make reservations in a hotel, two rooms, with planned arrival
the day before the conference, on Sunday July 11 ?
We

will provide

a

manuscript, according to your

instructions, before the stated date of July
Aberdeen.

1.

I look forward to the conference, and to visiting
Sincerely yours,
Max

York Medical College
Department of Psychiatry
New

Fink,

M.D.

�</text>
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                    <text>December 21, 1971
Dear Dr.

Kosterlitz,
In response to your questions regarding

my

report to the

Aberdeen symposium, I am pleased to submit the following:

1. International Conference on Drug Abuse: Published by the
University of Michigan Press. Page numbers are not available.

2. Wikler: pages 85—102.
3. Resnick et a1.: is to appear in Comprehensive Psychiatry,
in the issue of November—December 1971, which should be mailed to
subscribers in January.
The second report was not accepted for publication, and should
be reported as 'unpublished observations'.

4. Page 8, paragraph 2, line 4: reference should be 1968

for Fink, not
1972.

my

1969.

best wishes for

a happy holiday season and a healthy

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>November 12, 1969
M. Kraft
Professor and Chairman
Department of Psychiatry

Dr. Alan

The Albany Medical College
Albany, New York 12208

of Union Univ.

Dear Alan,

for your inquiry about an asoociate for psychoto mind - Dr. Martin Keeler, who
pharmacology.
North
from
Carolina,
appears to be unhappy
is at our College
Thank you

Two names come

New York-living
too expensive and all that, and
Dr. Gerald Klerman of Yale. He has had a new chairman and
has given up his position as Clinical Director of the
Connecticut Mental Health Center.

with

—

an eminent drug therapist with a keen
interest in hallucinogens. I find him sophisticated,
knowledgeable and capable.
Dr. Keeler

is

Dr. Klerman

is

nation's leaders in psychointerests in theoretical biochemical

one of the

pharmacology, with special
aspects of drug therapy.

I can recommend both men highly.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                  <elementText elementTextId="105851">
                    <text>Fr

,

m...

,

,

w

W -. -

.7“... .,.-_

..

.

.v.

n,

.-

“WW...

.7... ”V

_

m...

.. .._,.V _. ,

.1” .

.,..

,.

“‘

“1"

“PL

"urn-mtg“

March 1. 1970

(«II-um:

r
an:

Professor Alan Kraft

Department of Psychiatry
Albany Medical Collega of Quiet University
Albany, New York
ﬁaar Professor Kraft,

I have knawn of Dr. Keelar*a work for many years.
and nine; July, 1969, I have had more direct contact with
him in this Department of ?sychiatry. His record in North
Carolina is well known and his work there was of the calibar
tn receiva recognitian both by HIKE in its Carter Development
Program and by the University where he was promotad to full
Prefessor. Kin reasons for leaving ﬂorth Carolina seem to have

bten parsonalvv a desire of a New Yorker ta raise his family in
ﬂaw Yark-~ and not professional.

Since coming to New Ycrk Medical Collage, he has been
unable to make use of his abilitics~~ in part, because of the
liwited clinical facilities at his diagonal, and in part because
of the expcctntionu that funds ware already available, which were
indeed not yet awarded. ﬁe has carriaé out a teaching yragram
with psychiatric residenta and this has been done wall, for both he
and the students have been enthusiastic and they have raqucsted an
increase in their exposure to his teaching.

I believe him ta be a good researcher, capnble of undertaking prograns in aubutance abuse and schizophreniaww two subjects
of mutual interest. ﬁe writes well and his concaptualizatian of
a study program in cannabis was wall ptesanted. We understand that
tha project was racammended for support by the study atetian at
MIME but remains unfunéed because of the continuad lack of
a budget
for REV, rather than any inharent problem with the prtaentntion.
His persunality can best be described an raserved,
unassuming and mmdarately insensitive. He is forthright and cooperative
with his junior: and has exhibited the ability to relata to other
staff membara, particularly those in tha training divisions.

�Prof. Alan Kraft
We

.

.

.

.

.

.

.

.

.

.

.

. Page 2.

have not had an opportunity to evaluate his role as

administrator.

likeablo and cooperative in personal
matters, but uncooperative in his professional relationship with
a
I have

.
r

found him

part, this rooultad from the unfortunate assignment as
of this Division without an independent clinical base,
staff, most
requiring him to relate for patient mottoro with myRoaaaignmont
to
of whom are loyal to my ptinciplos and interosts.
him was difficult, and it soon become obvious that such a
partition of the limited clinical material woo not acceptable to
ma ; and a collaborative rolationabip with another Protease: was
him for
not acceptable to Martin. In largo port, I cannot bloom
have
not
his diaoppointmont, and I believe that his abilities
bad thn opportunity in this Department to oXprose themselves.

mo. In
member

«r.

W'fv”sz-m‘mwmuxw’mym-rsmuv.

'7‘“.

319.4,“.-

»«

v.
w

H'me

V731“

Ham

.»

'
.

l boliovo that he would do very well as a clinician
and a rosoarchot in a oooarate and well defined clinical facility.
Hie projoota will to wall prosentod and ovon in this competitive
climate» ohoold achieve rocognitoon and suyport. Ho relatos well
It
to students and bio toacniug will he acceptod with onthoaiaam.
him
this
$xooﬁmon
to
agpoﬁwtod
recommendation
that
3:.
was on my
Collage, and { bolﬁevo that if tho ?aoilitiao were aﬁoquato for
two oatallol programs, he would have been happy and have carried
out his work with distinction.
he should be given aoothor opportunity, and I am confident
he will be able
that if he to givan the facility and the authority,ﬁoxth
ﬁarnlina.
to achieve the potential doocriboﬁ in hio oath in

”M‘W‘V

.rw

v

I trust theoo

comments have

for tho succeoo of your program.

utility.

my

host wishes

Sincerely yours,

Pink, v.9.
Professor of Psychiatry

Max

of]

�</text>
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                  <elementText elementTextId="101355">
                    <text>March 12, 1962;

Irvin A. Kmft

Dr.

Dimctor. Child Study Clinic
Hamster: State Psydniatric Institute
1300

Wmd
Am
25 Tam

Hmtm
Boar

I

-.

Ir. Kraft:

3th

for reprint of ”Demlopmnt of pemeptim
tactile atixmli in
mum" . and ,mgmt
that: I cannot newly, 35mm this partisan-hr article is out at”
print. War, I am sending, in its stead, reprint of “maendured perception of aimltamems stimlatim of face and hand:
‘amview and theory", mich I trust will!» ofintamst bayou.
have year request

of

mi

Sincamly yours ,
Max

Fink,

Dimctor

HF/jb

v

war-.1"

mu-

v

H.113.

�</text>
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                    <text>-'

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September 4, 1970
Dr. Adam

J.

Krakowski

International College of Psychosomatic Medicine
Plattsburgh, New York
Dear Adam,

m...

nvmw

sea-yr.-

-.-.-v;

-.

interested in your suggestion to support the Inter—
national College of Psychosomatic Medicine; but as is generally
true for our academic programs, find no funds available to send
our staff to foreign meetings. As I am unsure of our participation
I

am

in Mexico City, I must decline your kind invitation.
It was fun discussing the Academy at the Pfizer symposium.
My

best wishes for the success of the

ICEM.

Sincerely yours,
Max
.

a
31‘

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Fink ,

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Professor of Psychiatry

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                    <text>~‘vv‘uﬁ an):

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r_. n

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:

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September 5. 1967
Dr. John Kramer

.
A.

_.H_

..

Chief of Research
Department of Corrections

Caiifornia Rehabiiitation Center
P. 0. Box 841

._..

W

“I“?

m

Corona, California

_
..

wary,“

Dear John,
be giad to have you visit on September 19. As you
can tell, the Brotman proposal is a straight socioiogicai program
quite distinct from the medical ~ pharmacological approach that

wiii

He

'rm'mamwg-WW;.

we

use

at Metropoiitan.

If

you

get to Great

(516)‘466-3158.

room and I can
My

If

ﬂock on Sunday. give

you wish to stay over

take you in

on Monday.

we

me

a

ring at

have plenty of

best regards.
Sincerely yours.
Fink, Moﬂ.
Professor of Psychiatry

Max
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                    <text>.V

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Hitch 6. 196k
Dr. John C. Kronor
Tho Lnngnor

Clinic

2807 Son Motto, R. B.
Albuquorquo, ﬂow Mexico
Dear John:

I hoop boating about tho beautiful weather that yen how: in the
Southwest. and almost had the opportunity to coma and visit you.
on tho oocoolon of the ﬂoating: of the Control EEG Soctoty: how»
over, I have boon ill and did not coma. Ho have received 15:80::
from Ann tolling of how will tho family local to ho doing.

m

w:

mw

h

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23-!

childron or: in tlptop condition, and Martha is in ochool.
She hos collootod ulna credits for hot nostor’o. and by May will
hovo ulna morn. If she stink: to her prooont schedule, I look
forward to hot moklng a financial contribution to the family in
1966!
Tho

W‘

,

I on writing today to revive an old problem ~ that of chlorpromazlue troatnont of doprosllvos. The HIH Committoo on Clinical
Drug Evaluation is considering a colloborotlvo study of dxogo lo
doproooloo. At my loggostlon, tho Comadttoo in considering a
study couporlng inlptaulna. placebo and ohlorptomozlno.'1n sovoo
hospitals for a total sample of more than 350. Howovor, tho Cpl~
mittoo members asked on to documont my ballot: that.ohlorproma31no
may ho

offeotlvo

1n

cortoln cases of dcprooslon.

I have looked through my rocords and find a copy of your first
draft dated August 1. 1962. Soon thereafter. both you and I left,
and I have no othor followwup data. I wroto to ﬂux, and he luggootod
that you any have the £1105 with you. Is that true? If no. I would
ho grateful if you ooold loud no whatever lotormotlon you hows. Moot
inportant. I would 11k. to have tho namoo of tho subjects whom you
finally included in the 32 who "worn unanimously constdotod to ho
loitering from a doprcollva disorder".

�Dr. Kramer
Bob-66
Page Two

I an oomntttod to oonplottng a roport
and would be

gtntoful for your holp.

by tho

first

week of

lay.

I do not know if you or. planning a visit Boat. but Eartha and I
would be dolighcod to how: you atop in St. Louis ootoucc. we are
planning on going to Europa this nun-or and on taking Jonathan.

who
Hy

will be thirtoon, with no..luavtag the girls with

has: rogurén to

Deana.

Sincerely yours,
Fink,
Director

Max

MP/Jb

M.D.

my

mochot.

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                    <text>...v.&lt;

“n

Hatch 26, 196‘

WWW—*wm‘wv-—m¢

FI"-Vwm"wwvv.wrwvsz—W"

wan:

u

Dr. John C. Kramer
The Langner Clinic
2807 San Mateo. H. E.
Albuquerqun. ﬂow Maxicn
Dear John:

—-

..

=mwmw—‘mw

mun—w‘w

v-

”F—nm-VHW

In trying to rewrite the depression paper, I dacidsd
I would like to use the information on thu STRS.

note: indicate that the scores ranged from 1.0
to 3.0. I naed a paragraph describing how these
numbers were derived. You will recall there were 32
items on the STRS, and these were rated from 0 to 3.

Your

Can you

Director

w-zt'r-r—

,
..

m

n...

mum.”

Wmmumw-wn-WWWWWW

derived theae scores?

ﬂax Pink. {4.1).

van-u

GW'WIJ‘VN'A

how you

Sinceraly yours.

m4

—-‘Ar.§n1?-—~.

:ecall

MY/jh

�</text>
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                    <text>my 6,

1964

Dr. John C. Kramer
The Langncr Clinic

2807 San Katee, R. 2.
Albuquerque, Raw Mexico

09;: John:

I

am sorry I missed you in California, but I an: year fathur
and stepwnother. and they both look wall and npakc most affac~

clonately of you.

Encloscd 13 the panultimnto of the depression rnport, which

has. tent out to members of the Clinical Committee for their
considerttlon. Unless I hunt otherwise, I will submit this
to one of the anger journals within the naxt few woeks.
Best regards.

Sincerely yours.
Fink,
Director

Max

Hfljb
Enc.

M.D.

I

~

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                    <text>Scptonbor 13. 1964

John 0. Kronor,

D.
Tho Longnor Clinic
2807 Son Mateo Blvd., N.E.

Albuquerque.

M.

Row

Mexico 87110

Dec: John:

Ihlnk you very much for your letter. Enclosed is a final draft
of your roport which has been accepted by Pharmacologgo.

I

saw Timmy in Great Neck, and had
the vcry poculinr fooling of seeing noncono I know well. In tho

As you know, soon months ago

unstructurod oontox: of children playing together, I could not
recognize his but as soon as be said his name was Timmy Kronor
I suddenly saw to old friend in miniature. we had a delightful
tin. togethcr and I hope to renew this by visiting next month.

on planning to be in Albuquorqoo on October 2, and would like
to be in Santa Fe by 7:30 p.m. for a symposium. and can spend
the cfcornoon with you. my plane will arrive oboot 3:00 p.m.

I

I

on looking forward

to seeing

you than.

Sincerely yours,
Fink.
Director

Max

Hrljb
ﬁne.

H.D.o

�</text>
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                    <text>October 19 , 19%
John C. Kremr, M.D.
The Langner Clinic

2807 San Mateo Blvd., N.E.
New Mexico 87110

Albuquerque,
Dear John:

Since leaving you I have had a trip to Washington
and now find nyself in St. Louis, able to relax and look
back on the events of the past two weeks. I was very pleased
with what I saw in Albuquerque, and the meetings in Santa Fe
the best that I‘ have ever attended. I want to
were
thank you and Dinah for your hospitality and for the oppor—
tunity to meet with some of your associates. You know that

mg

I

am very much excited that you are participating actively
in the University programs and I wish you all the luck.
In Washington, I met Dm lQein. He appeared anxious,

disheveled, and needed a haircut badly. He was attending
the meetings of the Society for Psychophysiological Research,
and except for the first half-hour, I saw him very little.
He was pleased that we were able to emplete the Depression
paper.

In Washington, also, I learned that the Psychopharmacology service center was planning a ten hospital collab—
orative program in the study of depression, and were going to
compare the effects" of placebo, chlorpmmazine and an anti—
parkinscn agent (perhaps pmcyclidine?) and imipramine. They
hope to have 500 patients and I see this as a wonderful ex»tension and replication of our studies.
My

Thanks again.

best regards

to. your

associates

and

Sincerely yours ,
Max

Fink,

Director

mf/ls

M.D.

yourself.

�</text>
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                    <text>June 2, 1965

.

Dr. John C. Kramer
2807 San mm, N.E.
Albuqmqm, New Mexico

Dear John and

Deena:

It has Manny months since nymmmble trip 13on Hexioo.
Ilaw‘talkedtoWImmymksu-yingtogethwandﬁm

ohildnntoagmemaemtrbﬂmghtlquLbutthey

madamtthatmleaatheygettoplaymabeachandswiminan
mtmntoﬂiaeowiin Swimmer. So it's back
mfthywillmt
East arm.
we of waeeooiatas. Hike Holden, and his family

However,

are?
'ﬂxe’triptiutImntedtotake. Hiketellamethat
heuillba SanteFeebmtJmelsmmybeinAnmquexqueon
‘

mtmm.

Ihevemggeatedthatheoallymaeheandhia
Peﬁnpayouoanarmnge
form(imidenully,ﬁike
mtﬂpforﬁmﬂntymmsted
mnhringyounp-tmdatemtmtrialsandtribalatimsofﬂumw

wifeambothintereetedinlndianlom.
Departmnt of Psychiatry or masouri).
we have

received many requests for your report

on depmeaives

andIluveuseditmemmberofoooesimsinaemixmtIntImVe

ludtogivebothinStlmisandinDetmit. 'meDetmitexperimoe
mintmatingbemueemofthemidentemadamntthatom'
oheemtim‘ueminmor. meofthesenior worm, however,
finally spoke up stating that he recalled clearly the therapeutic
effects that he had seen with ohlozpromeine in deprewives. 'me

Metudyiafullyhmmdwillreplioatemrstudyina
lamerpopulatim.

Finally, I an mloeing a copy of another bi~prodmt of the
Hillside experience, which I believe you will find interesting.
,

Weuieoedyouinﬂewiorkdm'ingtMAPA. Mar-ﬂujoinedm

formiau‘ipandwehadamderfultim,-imludingﬂuoeofﬂn
inyem (ifyouoan, see "FiddlerontheBoof,"
itmawaththevmoletﬂp).

about Broadway plays
My

best regards.
Sincerely yams.
Phat Fink, M. D.

Profeoow of Psychiatry

HEM:

oo:

Dr. Holden

�</text>
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                    <text>November 7 , 1966
Dr. John C. Kramer, Chief
Research Department
Department of Corrections

California Rehabilitation Center
P. 0. Box 8'41
Corona, California

Dear John,
Your

letter of

I hepe I gave

you

October 31, was received

the information

is a

this Homing.

you (asked on

the telephone.

of the program of the ARNMD and
relevant-pages from a recent bulletin of the ACNP. These
should be sufficient justification for your visit to New York.
Enclosed

When

copy

you have your program

outlined

and

let

me know

whenymwillbeinNewYom, Iwillmaketheneuessary
arrangements for your visit to this center.
My

best regards.
Sincerely yours ,

mx Pink,

MOD.

Professor of Psychiatry

111ka

�</text>
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                    <text>June 10. l968
Dr. John C. Kramer

Chief of Medical Research
Department of Corrections

California Rehabilitation Center

P. O. Box

l4l

Corona. California
Dear John,

Rockefeller Meeting on June Zl~22 has the aura of
religious conversion performance. I will probably ask a
member of my staff to attend on Saturday morning to see
if
the results have dropped below 97% success.
The

a

Saturdays in June are beautiful in

will probably find
How

me on

about coming out?
My

best to

New

York and you

the tennis courts in Great Neck.

Supper?

Deena.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>August

l,

1968

Dr. John C. Kramer

20l9 Camden Street

Riverside, California 92506
Dear John,
good news of your letter of July 14.
have heard of Irvine,
should be a great
university center, especially if some of the dreams of Gerard
come true in the application of computers to education. I would
be pleased to write a letter of reference. Do you want me to
send one spontaneously or shall I wait until I hear from them?
Thank you

everything

From

With a

for the very

it

I

little

luck I will be in Europe from actober l5~25.

Whether I am hate or not I hope that
you will
visit and I will arrange with my
staff to have you entertained and to show you our present programs.

This

may

not

come to pass.
have some time to

T e marijuana problem
a serious one although today
'l5 a UNQQUG day for me. sinceiswestill
did receive 500 mg of tetrahydro'
cannabinol from NIMH. This represents the supply that Jerry Levine
promised last summer. I was also called by Dan Efren who told me
that Aldrich Laboratories of Milwaukee are prepared to produce THC

for qualified investigators.

of the rumors from Washington regarding CNDA
or Psychopharmacolopy. The latest is that Sidney Cohen of Los Angeles
is taking Roger Meyer's place.
I know nothing

also received a large supply (probably
the world's supply) of naloxone for oral use and we will run clinical
trials during the fall.
In

addition to the

I look forward

THC I

to seeing you.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HFtkp

�</text>
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                    <text>August 12, 1969
Dr. John c. Kramer

Assistant Clinical Professor

Orange County Medical Center
lOl South Manchester Avenue
Orange. California 92668
Dear John.

September 12 is a better date for me. I am leaving for
San Diego on the 6 o'clock flight and would be pleased to see
you in the morning.
Stan

is

soon as he

away

but I will have him get in touch with you as

returns.

be in San Diego from the l3th to the l9th and if
back.
perhaps it would be fun to visit Irvine on
you are
TUesday, September 16, where they allow us a free afternoon.
I

will

I look forward to seeing you.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

iii-Elm

�</text>
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                    <text>July 20,

1969

Dear John,

.

It was good to recoiva your chatty latter. I had just
upent many pleasant hours with Elliott. diocuosing his programs
(at the A.M.A. and A.T.3. mootingo) and your letter rounded out
what I had hoard. The only note that teemod omittodffron your latter
that be highlighted was a possible study of ualoxono. If thorn will
be a better way of creating opiate addicts, it should coma from a compound with the specificity of naloxone. WE ate now at 3.06ms/day and
one of the contrnccﬂ that I discussed with Sid Cohen_uns on: for
embedding naloxone in silaotic.

WNW

,,._mm_,_.y_...._‘

‘.

Your visit during September will be most welcome. The week
you aoluctod, unfortunately in tho timo of the International EEG
aeotings in San Diego. Indeed, I had hdped to visit you during that
week. If you will be in How Yark, you should visit our unit. It has
some features quite different from Dole and Hyswandor. The beat
data can be gleaned from Dick Ronniok and Arthur 23kt, and I will
arrange to havo you spend some time with thou, if you wish. You should
also visit tho unit at Gracie Equare ﬁospital, to sea what a mothadone
program can do when it is out on a mooey~making baoin.

if

you will spooify tho time you will be to New York,
you to talk to our researoh seminar group on
your experiences. lhoso seminars ore infernal, attended by 10~12
members of the staff and some residents, and provide us with the
opportunity to discuss issues of interest to us. If you are agreeable,

I

woold

Also,

like to ask

I will ask stun Feldatein
in my absenoe.

(who monitors

the norios) to not as host

nave a good summer.

Sincerely yours,

Max

mf/

Fink,

M-Du

‘

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                    <text>7".

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July 5, i969

r.‘

i-

r'1

"n"

Dear John,

—rv'."rz-.-.4-'

"H'an-ava'r

The holiday has given me a chance To catch up on my reading,
have Jud? ro-raad your ”A Porspecfiva on Heroin”. if is a fine
article, and gives a clear image of fho hisfory loading +0 our present
inadequafe legal siluafion. i was remindbd of an infervleu i had in
May wifh fho commllloo of fho New York Academy of Medicine, ro—
assessing for fhe n'fh limo The need for changes in The medical
lroafmen? of oddicflon. i iold Them of our experiences with methadone
and cyciazocine, and whon i oxprossad some enthusiasm for +hoso
pharmacological froaimonis was asked if i fhoughl They were ofhicai.
The mean age of fho commlfloe members was suroiy 75 yoors. i avail

and

«

"1‘01,

-.

_

é
"
wv

wuwnyna—n

-.w,.-r
,

.
iv

'

anrv-u-ur—mn-mu.

i

fhoir reporl wilh

some

anxiety.

also read your AMA reporr and if is mos? sfraighf—forwnrd.
will probably be disregarded by everyone in ihe legal profession,
bu? for us if will remain an imporfanf reference. Brofmon and Freedman
both expressed approval also.
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should have moved +0 your

new Doparimeni, and
be as produclivo there as you have
in The slain programs. Sidnoy has found a new home and moved in lasl
week (lil Ferry Slroof, Barringlon, R.i.i, and is raking his family lo
Soufh Africa for a visif fhls monlh. My son, Jonoihan, has graduofod
high school and will a++ond Colby Collage in Manna lhis fail. Mnrfha
has enjoyed her Teaching in Gran? Neck very much (quite a difference from
fhe For? Washingfon school) and looks forward lo continuing. For fho
summer she is faking The girls on fhoir firsf European frip, on a
By now, you

l

lrusf Thai

you

will continue

To

mini~grand Tour.

Our own work is progressing slowly. The molhodone program
confinuos lo be succossful; cyclazocino also, alfhough more care mus?
be exercised in froafing fho paflonfs. We havo looked of fhe problem
of dofoxifylng Those parienld on moihadono for more fhan 2 years, and
who may be making a good adjusfmeny. We Tried To do fhis ulfh The
agroemonl of fhe subjecls and fho sfoff, and failed. We aro now
fransforring pafienfs from methadone fo cyclazocino (blind) and have
begun to decrease the cyclazocino donage. So for, no wllhdrawai and

no

difficulfies wifh anyone.

zv-l

Naloxono confinues To be a difficult problem. ifs durallon
of aciion of 2.4 ems/day is about 24 hours, bu? lho company provides

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�v(

.

spun-um.

by.”

v'r

tablets onlyan and have you ever tried to get addicts to take
24530 tablets at once ? daily 7 voluntarily 7 7 To get around this
problem we are trying to develop a long acting form of naloxbne, using
the principle of embedding in a sliastic vehicle. We have asked NiMH
(Sidney Cohen) for a contract to proceed in this development, but he
seems less enthusiastic than we would like.
iOO mg

research.

Our

principal effort for the present is in marijuana

to our staff, and
visit to Greece, l visited
the laboratories of Konstantin Mirase- found them ever so much better
than
anticipated, with fine chemistry facilities, excellent
Al

he begins in

Freedman has appointed Martin Keeler

mid-July.

On

a

recent

i

neurophysiological equipment (under the direction of Dr. Stefanie,
an NIH trainee) and his own garden for growing cannabis. Dr. Miras
is an expert in the plant growth, constituents, etc., and any project
that works with his help, must be better than the trash being published
today. (Have you seen the recent article on driving comparing 2

cigarettes of

NlMH marijuana with 0.l mgz blood label alcohol ?)
desire is to formulate a study program in Athens and Al and
have proposed this to NlMH (again, Sid Cohen) as a contract. Of
course, we are now anxious to undertake some extensive, long term
studies here to assess the neurOphysioiogic, behavioral and

Our

l

psychologic

effects of chronic marijuana use.

it

has been a busy year, for in addition to the narcotic
have continued studies in ECT, EEG and even in schizophrenia
and anxiety. Any chance of a visit the next time you are in New York ?
program!,

i

One

last

comment.

i

attended

a

special open session

on

marijuana held in New York in June under the direction of Representative
Koch (U.S. Congress). Brlii, Fort, Cohen held the MD lids and three
lawyers the legal side. My first exposure to such sessoons. Lots of
name calling, arguments ad hominem, and most impressive, the repeated
plea for more studies. Even the young people asked for more data, and only
Henry Brill was sure that the drug was harmful, regardless of the data.
it was a wild session, and Representative Koch expects to propose a
bill to set up a study commission on cannabis (like a President's
Commission).

Keep up the good work, and many thanks for the fine articles.
have not obtained permission for our study of methadone in
psychosis, but it is less important now that l have other interests,

We

still

although

it

My

should be done.

best regards to Deena.
Sincerely yours,
Max

Fink,

M.D.

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July 5, i969
Dear John,
The holiday has given me a chance #0 cafoh up on my reading,
have Jusf rewraad your “A Perspecfive on Heroin". if is a fine
of tho hlsfory loading +0 our presenf
ariicie, and gives a clear imoga
inadequafa iogai sifuaiion. l was rominddd of an interview i had in
May ulfh fhe commiffea of fhe New York Academy of Medicine, ra~
assessing for the n'fh +ime the need for changes in the medical
ireaimenf of addicfion. i fold ihom of our oxperionces with mofhadone
and cyciozoclno, and when i oxprossod some onihuslasm for Those

and

i

pharmacoiogicai froafmonis was askod if

of fha commiffee membors
+heir roporf wilh some anxieiy.

The mean age
i

i

was

thought fhey worn

surely

75

years.

oihlcai.
i

awal+

reporf and if is mosf siraighf—forword.
be disrooordod by ovoryono in +he legal profession,
will romain an importanf raforenoo. Bro+man and Freedman

also read your

if will probably

AMA

bu? for us if
boih expressed approval also.

should hovo moved +o your

Deparimeniﬂ and
you have
in The siole oroorams. Sidnoy has found a new home and moved in lasl
nook (iii Ferry Sireof. Barringfoo, P.i.i” and is inking his family To
Soufh Africa for a vial? This monfh. My son, Jonathan, has nroduafad
high school and will aifond Colby College in Maﬁno this faii. Marfha
has enjoyed her Teaching in Gran? Neck vary much (quife a difforonoa from
fhe For? Washington school) and iooks forward +0 confinuing. For fhe
summer she is iaking ihe girls on +hoir firaf European irio, on a
i

By now, you

frusf That

you

new

wiil conflnuo to be as producllvo #horo as

minl~grand Tour.
.

Our own work is progressing slowly. The noihodono program
confinuos +0 be successful; cyciazocino also, although more care mus?
be oxercisod in frooflng the pafienfs. We have iookod a? the problem
of defoxifying Those pafienfs on mefhadono for more ihan 2 years, and
who may be making a good adjusfmeni. We fried To do this wiih The
agroemenf of iha subjecls and fho staff, and failed. We are now
lransforrlng pa+i9n+s from mo+hadone +0 cyclazooine (blind) and have
begun #0 decrease fhe cyclazocine douage. So far, no wlfhdrawai and
no

difficulties wifh anyone.

Naioxono confinuos to be a difficult problem. ifs duraflon
of action of 2.4 Gms/day is abouf 24 hours, buf fho company provides

��l\\\
‘

iOO mg labiols only~~ and have you over friad lo gal addicts To fake
24530 +ablofs a? once ? daily ? voluntarily ? i To gel around lhis
problem we are frying #0 develop a long acflng form of naioxbne, using
the principlo of embedding in a siiasfic vohiclo. We have asked NIMH
(Sidney Cohen) for a coniracl lo proceed in fhis developmanf, bu? he
seems less onihusiasfic Than we would liko.

Our principal effort for the presonf is in marijuana
research. Al Freedman has appoinfod Marfin Koelor fo our sfaff, and
he begins in mideuiy. On a recent visif fo Greece. l visifod
The inborafories of Konsianfln Miras~~ found +hom ever so much heifer

fine chomisfry faciliiios, oxcoilon?
nourophysioiogicai equipmonf (under +ho diroofion of Dr. Sioianis,
an NiH Trainee) and his own garden for growing cannabis. Or. eras
is an oxpari in lhe plan? grou+h, consliiuenfs. etc., and any projaci
fhof works wiin his holp, musl be boiler fhnn The Trash being published

Than

i

anliolpafod,

wi+h

foday. (Have you noon rho recon? article on driving comparing 2
clgafolfos of NiMH marijuana wifh 0.! mg% blood label alcohol 7)
Our desire is in formulate a niudy program in A+hens and Al and i
have proposed this lo NIMH (again, Sid Cohen) as a contract. Of
course, we are now anxious +0 undoriako some oxfonsivo, long term
siudies here To assess iho nourophynioiogic, behavioral and
psychologic offocfs of chronic marijuana use.

in oddifion fo fho narcoiic
EEG and even in schizophrenia
in
EST,
have.oon?inund sfndios
programs,
and anxlofy. Any chance of a vial? lho nox? limo you are in New York ?

if has
l

Ono

lost

marijuana hold in
Koch

been a busy year,

for

l offended a
special open session on
York in June under The dirooiion of Foorosonfaiivo
Brill, Forf, Cohen hold The MB nine and rhreo

commonl.
New

(U.S. Congress).

iowyorn fho ionnl nido. My first exposure To such sessoons. Lois of
name calling, arnumonln ad hominom, and mos? impressive, ihe ronoofod
plea for more sludlos. Evon fho young poopio asked for more dofa, and only
Honry Brill was ouro ina+ +ho drug was harmful. regardless of The daio.
if was a wild session, and Roproseniaflvo Koch expocfo +0 propose a
bill To 99+ up a sfudy cemmisnion on cannabis (like a Prnoidonils
Commission).
Knop up the good work, and many thanks for lho fine arfioioa.
have no? obfained permission for our sfudy of mofhodono in
psychosis, buf i? is loss imporfani now lhof i have other infarosis,
although if should bo done.
We

sflii

My

best regards lo Deena.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>.

m.

.w...

—..

,_

-w

..

.r‘-,.n.w.~7.—l....-

V

—.....w

May

,m, up", v

’HW&lt;

,nv‘nwﬂ'vml'r.

.n mp. ...

Ivar-nzy. ,7"

29, 1971

Dear John,

I am delighted that you will be able to assist us in
developing the program for a heroin delivery system. We would
like to have you join us June 22~23 in New York, and we will plan
the necessary steps in developing the project.
The

trip to

England

is in the planning stage and
it is necessary during

should be able to decide what and whether
your visit here.

we

and

FDA

project.

Next week, we have appointments with the BNDD, NIMH
to clear the politics and medical essentials of the

In the meanwhile, any literature or data that you have
with regard to experiences with heroin, heroin maintenance,
heroin tolerance, and its pharmacology, should be collected
and the citations brought with you when we meet.

If

you

My

best regards.

will stay with us,

we

would be pleased.

Sincerely yours,
Max

.
rm»...

CNM
‘

Fink,

M.D.

»

_-_.- w-r-

~

W'w‘i'.1‘

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                    <text>November 5, 1977

John C. Kramer, M.D.
California College of Medicine

Irvine, California

92717

Dear John,

I was glad to hear of the work of J.G. Kennedy. I had
of it, and suggested the study only because I had been
encouraged in it by Dr. Krikorian. Obviously, Kennedy is a better source
of the latest information on qat. (Incidentally, do you think I can
use 'QAT' in scrabble ?)
not

known

Your analysis of the Chopra and Knight data is excellent.
these reviews I still believe the question of what they were
describing is active and their samples should be re-examined. I do
not know what NIDA would do_with an application now, but they are
obliged to respond to every formal request for funding. From my past
experience, a visit to Steve Sears and some of his co—workers is a
must before a study is contumplated overseas since the funding will
have to be of a contract form. It will provide a way to catch up
on the latest studies and to find out what is in the pipeline (like
From

it

If you can visit Washington, do so. Or, is
you may attend the next meeting of the ACNP in Puerto
Rico (December 13—16), when
is likely that Sears and his staff will
the study of Kennedy).

possible that

be present

it

?

I know of the ocualr tracking test only what is popularly
the literature. Don Klein asked for a small grant from
Stony Brook in 1975 to get the equipment to do a study. Perhaps he
is up—to-date on the dindings. However, it is unlikely that a new test
could be a definitive basis for a discrimination, until at least there
is a large body of acceptable data in known schizophrenics, and this
I think is lacking.

known from

I have no trip west scheduled ahead of me now, so I hope
can get together when you have an excuse to come East. Let's make
soon.

we

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

it

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                    <text>'l'-‘Ww-'2-m r.

.

..._

I.

,. ,

September 30, 1977
John C, Kramer, M.D.
California College of Medicine

Irvine, California

vawllw

Dear John,
n

.

study
have re—read your suggestions regarding a hashish
following
the
with
comfortable
a number of times, and now feel
comments.

I

related
classification of four classes of hashish
It
nature
in
How
occur
many types
psychoses is a theoretic one.
that
possible
is
answering.
It
is this latter question which needs
Spuief and other
Chopra,
and
that
exist,
psychoses
the different
astute enough
been
have
example)
observers (Knight in Jamaica, for
to do so. It
failed
have
to describe them whenﬁiestern observers
all) these
(or
Do
any
is this latter point that needs follow—up.
in users ?
exist
mental states
The

T

theoretic types of hashish related

who
suggestion, that of finding individuals
and re-exposing them
have recovered fram a cannabis related psychosis the question: Cann
to
to hashish, is a good way of getting an answer
mental state 7 But, what

The second

cannabis inhalation precipitate an altered
individuals to a pathogen
of the ethics of exposing presumed 'sensitive'
be
built in to protect
could
How about the safety ? What safeguards
?
even if the acute
And,
a subject who becomes psychotic (again)
complains of
the
what
patient
if
episode is treated successfully,
?

recurrences ('flashbacks')
I would
As for the 'backtracking' pf Souief and Chopra,
that hashish
not assume that they have given up any of theirandopinions
that theta are a
psychoses,
is dangerous, that it precipitates
and euphoria
stimulation
variety of mental states, from transient
of hashish
result
a
as
which
occur
to a schizophreniform psychosis not unique for others subscribe as
are
use. In this opinion, they
assuredly, and my co-worker, Stefania
H.
Brill
and
C.
Miras
strongly:
that needs checking. Since we
probably. It is precisely this issue
whose psychsiisits
are unable to define a population of psychotics
those patients whom
of
study
perhaps a
directly related to cannabis,
Hence, the suggestion to
others see as related would be more useful.
happened to Martin
examine patients with Chopra or Souief. (Whatever
psychoses
Keeler-- he has described a series of cannabis precipitated

?

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John C. Kramer, M.D.

.....

"art's:

,_,

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September 30, 1997

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in students in South Carolina 7).
similar issue is developing about the use of another
'hallucinegen', khat. Khat is a plant derivative which is chewed
by the natives of Abyssinia, Sudna and Arabia for its 'stimulation'.
A

I

it

described, khat is used much as we use a coffee
break-- a relief in a set of monotonous chores. The plant is pro—
scribed in these countries. One member of our faculty, Professor
Krikorian, is a national expert and has urged me to undertake a
study of its pharmacology, physiology and to go with him (after
the present wars are settled) to Abyssinia. You may want to look
up what you can find first, and if the matter interests you, I
As

have heard

will send

.

you my

file.

,_...v..,,.e.

begun a volume on convulsive therapy, and that
is keeping me busy. The EEG studies are going well, and I now have
one good clinical unit at the VA which seems able to do good work.
Mostly with schizophrenic veterans, a complex group to assess. But
the work is interesting.

I have

$7,,

w

w“

“mm-mm"

Thanks

Arr

some

r»;

interest.

My

for your ideas. I
best regards.

hope the responses are of

""V-m7m'

Sincerely yours,

r—w—m-

"W-‘W'v‘el‘f'

Fink, M.D.
Professor of Psychiatry

Max
«run-rr-w

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                    <text>w.
John C. Kramer, H.D.

August 22, 1977

University of California

Irvine, California

Dear John,
NIMH

I will continue to be optimistic that the funding from
will yet come through; but will answer your inquiry in the

meantime.

The book on

the Greek study

was

published in July and

should be available within the next few weeks. In it, as in the
prior Jamaica study, and the one from Costa Rica to follow, there
is little evidence that chronic hashish (ganja) smoking has any long—
term effects. These observations are in direct contrast to the
earlier literature, particularly from India and Egypt; and the more

recent reports from these countries by Souief and Chopra. Their
latest data may be found in the 1976 conference proceedings (New
York Academy of Sciences, vol 282, edited by Dornbush, Freedman and
Fink) where these authors cite large numbers of psychotic cases
which they ascribe to hashish use. Not only do they cite evidence
for psychosis, but criminality (other than possession of hashish)
as well. Chopra does not limit his findings to patients in hospitals
in India: he says that in interviews with drug users (site ?) he
made the observations. Souief worked in prisons, so his population
also is not a hospitalized one.
I would resphrase the question: Considering the differences
in incidence of behavioral abnormality, including psychmsis, reported
from India and Egypt compared to the studies in Jamaica, Greece, and
Costa Rica, could the findings reflect differences in material smoked;
in the observer ratings; in the sample populations selected for study;
or in the standards used for diagnosis ? If one were to start in
India, it would be important to visit Chopra and assess his populations,
his methods of assessment, and the material his subjects smoked first. If
some differences between the studies emerged from these observations,
they can be verified in subsequent studies.

If hospitalized patients are the focus of study, one could
with Frank Knight in Jamaica. In the Same NY Ac Sci volume, he
has a report, mostly anecdotal, but well written that there is a
defined incidence of psychosis due to ganja. In Athens, Miras was
still convinced that this was true, but when a Greek team visited
the major mental hospital, they were unable to verify a cannabis psychosis
syndrome in the patients hospitalized for a long time. Perhaps the same
start

�FTWT‘Q‘WFTJ‘Wﬂw-l‘ew-Iwuww‘mwv-u-s‘h‘m4"
,

Kramer, John

-4“...

,

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...........

1.,

x

_
.. u. m true
.,. 3!

V." —wvmr_wmmw .W77_~w:_~~r,..-wrn ......-w~...w.(—I WW»,-

August 22, 1977

..............

page

in Athens could be done in Jamaica. There
advantage of language~~ they speak English.

re-assessment

made

.n...»w:v”v~-w-v‘--—\.c..._.e._

2

is the

«Wm—7

..

..
~v-v!

“3...-

sum—”m.“

mm"

for anthropological and sociological studies is
did not answer these questions at all, partly because we
great.
wished to focus on the findings reported by Hires, that most of
his users had brain damage. But the more interesting question
emerged in our study, as in others: why do cannabis users continue
to use the drug ?
The need

We

There are many

first steps--

one

is outlined in

your

letter.

is to call or visit Steve Szara and get a picture of the
present studies in progress, and the possibility of undertaking such
a study in India. I would also suggest that you write to Dr. Chopra
after reading his report and asking whether he would cooperate in
other studies. Perhaps someone from NIDA is already there. If not,
and Chopra is willing, I think it should then be possible to formulate
Another,

a proposal based on his observations (much as we did with Miras'
observations) with the additional data from Szara (and perhaps

Petersen). Finally, you would do well to visit a number of
the others still interested in this question, to get an idea of
what the present thinking of the chronic cannabis syndrome is:
Sidney Cohen, Vera Rubin, Henry Brill come to mind.
Bob

r
.r-

-&lt;.

From my awareness of the issues, the NY Ac Sci volume
provides the basis for the questions to be answered. The Greek, Jamaica,
and Costa Rica studies are internally consistent in major matters——
only the Indian and Egyptian data are incongruous and I think that
this is the area of study now.

vw,‘-—r‘.-'Hw.fyr

I said in Irvine, I would be pleased to help you develop
such a study, and when the time comes to negotiate with NIDA or other
As

agencies for support, I have

some experience wﬁgich may be helpful.
will need a social-anthropologist or anthropo-sociologist in
addition to your psychiatric background. If you need a psychologist,
and I think you will, then one aware of cultural differences in
testing would be the one to identify.

You
.:

1""vale

Mm

w-

--~

1:"

us.

puma-warm

_.
aw."

Separately, I am sending you a copy of the
I think the questions come from it's papers.
My

NY

Ac

Sci volume.

best regards.
Sincerely yours,

cur—or.“

.

-

vacuitwn'ﬂrnrxx

"v‘

‘

Max

Pink, M.D.

Professor of Psychiatry

.

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29 , 1966

Dr. George M. Kmuthmr
117~16 Bath Avenue

Ridmmd Hill,

New

York 11MB

DearGaorge,

Imderstandmer.Brooksthatywwillbe'intom.
thnymfindyamwaytothisOollege,orifym}avea

'7

mm,muldymcmtocallonm.
Mybestmgards.

Sincerely yams ,
'

Max

Pimc,

rm.

Professor of Psychiatry

MF:kp

�</text>
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25 February 1974

Edwin A. Whinstein. H.D.

Professor of Neurology
Sinai School of Hcdicine

Mbunt

Awenna and 100th Street
York, New York 10029

Fifth
New

Dan: Ed:

I look forward to joining you
tion of Morria' service on Friday,
Thank you

and Mbrria at ch: comaemorn‘
March 15, at Hbunt Sinai.

for your invitation.
Sinceruly yours.
Fink. M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>ﬂovmber 30th, 1972
Mr. K. DeAmond Kirkpatriax.
Assistant Direetor,
Charlotte Drug Educatiem Center. Inc. .

“16

E. Manhood

5t. .

Suite "201,
Chnrlotte. North Carolina
Dear Mr.

Kirkpatrick,

2830b.

'

In addition to the usual treatmnt modes which are
well known, such as mthadone maintenance, detoxification.
rehabilitation. etc. . we would suggest that you include
in your program some Macmillan of narcotic ammonium .
I know this is difficult since there are only a fur centers
am a few peozgale qualified to discus: this complex subject.
but I am sure that with the help of the National Institute
of Rental Health you will ﬁnd what you need. I an encloung
a recent paper which may be or same help.
Sincerely yours ,

Fink, M.D.
Professor of Psychiatry
Max

10/13

ﬁne

at

�</text>
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                    <text>E

May 30, 1988

David Kroessler, MD.
Department of Psychiatry
Rhode Island Hospital

Providence, RI 02903
Dear David,

Last month you enquired about support for continued research in ECT. At
the APA meetings, I became acquainted with the NARSAD program. This looks like
an appropriate place for you, with Barry's support, to obtain funds for your
research.
Good luck.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�April 7, 1988
David Kroessler, M.D.

Department of Psychiatry

Rhode Island Hospital
Providence, RI 02903
Dear David,

I know of no special foundation grants in electroconvulsive therapy. From
time to time, we have been able to get special funding for a seminar or a
colloquium at a meeting from some of the ECT companies or a few small
foundations. But felloewship money sufficient to allow someone like yourself to
develop an academic career has generally come from the National Institute of
Mental Health.
'

There has been an announcement of a new career fellowship program for
medical graduates who have less than five years of post-residency experience. You
may qualify and should consider applying. One applicant called me and asked
whether I would agree to having him study here for a training period of one to two
months, and I agreed. If you wish to arrange such a training program, I will do what
I can to make the arrangements at those centers that may be of interest to you.
As for project grants, these come exclusively from NIMH. There is a
fund
at Veterans Administration hospitals which allows investigators to get
special
funds
($25,000) and then to apply through a special VA funding program.
start-up

The work here is going well. We have started a five-day CME 'hands-on'
training program in ECT. The first class went through in February; we are
scheduling the second for the week of May 16. Our research projects are running
well and we have a steady output of papers. Larry has taken over the ln-patient
service; Krish Gujavarty is moving to the V.A. I append a list of our active ECT
projects for your information.
Tell Barry that I included a review of his book (which I like very much) in
the next issue of CONVULSIVE THERAPY. My best regards.
Sincerely yours,

Professor of Psychiatry

�</text>
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                    <text>w.

Nwanlnﬁm

-v

.

Viv-wow.“

1-,

~wnmw~,_v—wwr

~

saw-7w“... .-.

auto-yrr'm‘N-r 4‘

"n "w mm ww’vm‘“W's-mm-:«--v~v,vn‘ww.

October 31, 1969
Krohn~Hite Corp.
580 Massachusetts Ave.

Cambridge, Massachusetts 02139
Gentlemen:
May

I please haye a recent condensed catelogue,
and the

particularly of your variable electronic filters,

name

of year local representative.

I am

interested in

It

would be usefhl
an

to have him contact me as
equivalent to the Krohn~Hlte 355R.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

�</text>
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KrohnaHtte Corporation
580 Massachusetts Avenue

.

Cambridge, Massachusetts 02139
Gentlemen:
We are anxious to get a set of filters which may be
suitabie to use for the modification of EEG signa1s before
analysis. Hou1d you kindly send me a capy of your catalog
describjng your line for this purpose and the name of your
closest representative in New York?

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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ll.

1967

Krohn~Hite Corporation

580 Massachusetts Avenue

Cambridge, Massachusetts 02l39

Gentlemen:

are anxious to get a set of filters which may be
suitable to use for the modification of EEG signals before
analysis. Would you kindly send me a cepy of your catalog
describing your line for this purpose and the name of your
closest representative in New York?
He

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 13, 1969
Dr. Dirk Krﬁnig

Bucklestrasse 1-5
Konstanz, Germany
Dear Dr. Kronig:
We are
a get together in New York after the
EEG Meetingsuof investigators interested in
Internationaplanning

EEG

as a

and psychiatry.

participant.

I look forward
September 25, 1969.

A

Dr. Kunkel has suggested your name

formal

letter of invitation is attached.

to geeting

you in our

laboratories

Sincerely yours,
nt‘

a¢Lg KL gu48

Mszp

Fink, M.D.
Professor of Psychiatry

Max

aéycat

on

�</text>
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                    <text>StOﬂYBIOOk

Department of Psychiatry and Behavioral Science
Health Sciences Center
State University of New York at Stony Brook
Stony Brook, New York 11794-8101
telephone: (516)

444—2929

June 15, 1989
Mr. Wolfgang Kudrnofsky
ORF
ORF

Centrum

Vienna, Austria
Dear Mr Kudrnofsky,

It is clearly difficult to

communicate

at this distance.

While

I would like to be cooperative, it is difficult to do so. We are not a
source of film or video materials, but we are members of an academic
department of psychiatry at a medical school. As such, we have
collected some materials for our students and teaching, and have, at

these available to others, including radio and television.
We do not do so for stated fees, but will cooperate if the
objective is within our missions as educators. As such, we ordinarily
serve as consultants. As such, we usually obtain our satisfaction in
our teaching, and to a lesser extent in the fees for our time.
From time to time, we have been asked to allow the media to
film our patients, before, during, and after treatment. We generally
are able to obtain patient and family cooperation and for such efforts
we generally ask that they be paid at prevailing commercial acting or
consulting rates.
If you wish our help, you or one of your associates should
discuss the details of your proposed programming, and we
visit us to be
will try to
responsive as to what we can provide.
times,

made

Singzzzjy

.4 Fink,

yours,
M.D.

Professor of Psychiatry

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April 10, 1989
Dr. Wolfgang Kudrnofsky
Gsterreichischer Rundfunk
Wiirzburggasse 30
1136 VIENNA
AUSTRIA

Dear "Dr. Kudrnofsky,
Over the years I have collected documentaries of ECT and Metrazol shock
therapy, and recently I made some videotapes for my students and patients. Our
materials have been used by the major American television networks and BBC.
The source of the older material is diverse and the quality fair to poor. It
would be necessary to see the material and if any is of interest, we can then decide
on how best to get consent from the sources for your reproduction.
The recent material is also diverse. 1 have academically made 'teaching'
tapes, some abstracts of commercial tapes, case material of interviews of patients
before and after ECT, and finally, two commercially made videotapes developed as
teaching tools for our students and our patients. For our patients, the tapes are
used in obtaining 'informed' consent for electroshock therapy.

It would be useful to know what use is planned for these materials; the
anticipated size of the audience; number of reproductions; whether you are
requesting our tapes for your editing, or whether our participation in the
presentation is also requested.

—-

1 do
not have lobotomy or insulin coma films but am acquainted with
of
sources old films, made for teaching purposes.

can be reached most mornings at 516-4“; 2929; and most afternoons and
evenings at 516 862 6651. Our FAX is 516-4“ 753$.
I

Thank you for your inquiry.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�May 23, 1939

Dr. Wolfgang Kudrnofsky

Osterreichischer Rundfunk
Wiirzburggasse 30

1136 VIENNA
AUSTRIA

Dear Dr. Kudrnofsky,

it is not clear

from your FAX of 12 May what more i can tell you.

Videotape of new material (ECT) made in the last few years is available.
The older material of insulin coma and Metrazol is on film.
We are not a commercial source of educational material. As an academic
institution, we use educational materials as part of our teaching and consultations.
We have worked often with producers and educators to develop teaching
programs,
and if you wish us to work together, please outline the aims of the project. The
expenses and fees for such consultation depends on the demands in time and effort.
1

am not sure that we can obtain lobotomy films but there are some sources
if the program requires specific footage.

that we can try

Since rely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>,,, may, :- wﬂ

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“1"

March 29, 1971

J. Kuhn
C. H. Boehringer Sohn

Dr. Franz

Ingelheim an Rhein
west Germany
Dear Dr. Kuhn:

we look forward to your visit in New York this spring.
Dr. Terry will make the necessary arrangements for your stay,
and I am writing to raise a few questions so that we can
provide the facilities most useful to your visit, and establish
a relationship which may be most useful.

In our laboratories, we are now carrying out EEG classification
studies of new drugs in volunteero; assays of marijuana, both
acute and chronic; and reviewing data from earlier studies of
marijuana, ECT, methadone, 233. You may wish to observe our

recording and analytic work; to participate in or undertake an
on~going study; and/or analyze the data of one of the projects.
You

also

may

wish to familiarise yourself with the analytic

- the computer analyses, statistical processing and drug
classification, either of an ongoing study, or a completed one.

programs

If

actual

of

EEG

you wish, we can also arrange for someone to review your
program needs, assuming you wished to do some processing

data in your laboratories.

With these facilities in mind, would you provide us with the
questions which you wish answered; or the goals of your visit. An
I correct to assume that you are interested in establishing a

collaborative or a consulting relationship, both for studies in
animals and man, toward identifying and developing new psychoactive
drugs?

If these questions are

indeed the focus of your

visit, it

would

be helpful if
descriptions of the principal
items of equipment now in your laboratories, particularly the EEG
you would send us or bring

w-w

5

�,

-.

raw-.1.- vanes-V:-(w

xvamv...‘ .nwuvgw,. w 5‘

y—v 300a"?

“m

-2-

Dr. Kuhn

Hnrch 29, E971

tape recorders
year, capacity for tape recording),
model, peripherals,
(make,
and
computers
model, speeds, tape size),

amplifiers
(make,

.-va~

size of

(mnkc,

memory).

Again,

I look forward to your visit,

productive relationship.

and to developing a

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
cc: Dr. E.

N. Terry

�</text>
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                    <text>August 20, 1971

J. Kuhn
C. H. Boehringer Sohn
Ingelheim, Germany

Dr. F.

Dear Dr. Kuhn,

studies here

have been completed according to the
protocol you completed on July I. The data has been analyzed and
the statistical analyses are now in progress. As soon as these
are completed and the staff has written the summaries, I will
send you a copy. I do not know, as yet, what the data will show.
The

for

viiit

to Ingelheim, I am scheduled to be
in Wﬂrzbnrg from September 23 to the 27, and must be in
Amsterdam on Wednesday evening September 29. I would suggest
we plan to leave wUrzburg so that I can be in Ingelheim on
Tuesday September 28. This will leave Wednesday to make the
travel connections to Amsterdam.
As

my

I very much enjoyed your stay with us and I hope that
you found it regarding. my best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>October 22, 1971
Dr. F,

J.

Boehringer
Ingelheim

Kuhn

Dear Franz,
Dr. Stockhaus has written, requesting naloxone
for his research into the narcotic antagonists. I am
pleased to enclose a supply for his use in animals.
powder

..
v,
,.

“q...

..

I have not had the time to review the report on
but as soon as I can see the top of my desk, I will
get a copy for you.
l—Dopa,

-

I hope our meetings were helpful.

.‘.,

..

“Neurm,”

My

best regards,

and Happy Hunting

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

-4

,A

,1,

.

Jimmy-vr-w-«ww—a—mr

r.»
,——
-

Mair-2r"

Twmn-hx‘wjﬂ

Mp4»-~M-,i-

7,.”

, ..

,

,

.L, #,._.V -zﬁ 7,77,; .w"
-7

,

k

.,

-,.

,

,

.-.—,-.-..n_-:«. M» ~_.

�</text>
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                    <text>September 12, 1971
Dr. Franz Josph Kuhn

Boehringer-Ingelheim

West Germany

Dear Dr. Kuhn,

data of the GPA—l Dopa study is still being
analyses are completed and these show some
effects for l-Dopa but more for GPA. The l-Dopa effect is
probably not significantly different from placebo.
The

analyzed.

promise

The EEG

The boys

it

are

now completing

the behavioral data, and

by the end of the next week.

I am writing today to clarify some points about my next
to
Europe. I plan to be at the allep EEG meetings in
trip
wurzburg, and had hoped to arrange to visit Ingelheim with
you, should this type of visit be useful to you in discussing
EEG analyses with your oo-workers.
Earlier this week, Dr.
Terry called to say that attempts were being made for me to
visit Munich and to hold some conferences in other laboratories.
While such visits are most enlightening and occasionally useful,
I do not have the time to go on the lecture trail during this
trip. It is necessary that I spend as much time as possible
in Athens and Amsterdam.to carry out my own work in these

cities.

For

this reason,

and since I have not heard directly from
planning to go from Wﬂrzburg to Athens. In the event that
a visit to Ingelheim would be potentially useful to you and to
my laboratory, I shall be pleased to arrange a visit on another
trip, as I plan to be in EurOpe on a few occasions during the next
six months (until my work in Athens 15 completed.

you, I

am

I will send the data and the analyses as soon as the boys
have completed the work.
my

best regards.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>”:4

,t'vrwﬁu,""

v-

January 9. 1975
Dr. Khlkerni

Associate Director, Peychophermecolosy
Abbott Leboretories
Earth Chicago. Illinois
Dear Dr. Knlkerni,

Professor

suggested that I send you the enclosed
Itil
some of the date from our
which

represent
papers on Thoudelteu9,
studies or the cannabis derivatives.
studies in
initial
EEG

Kev York, we were interested
end
defining the significance
effects
in characterizing the
merihunne
and heshish.
THC—deltep9
of
in the response of

In our

we confirmed

these observations in occasional users

by similar studies in long term chronic hashish nears who had
clear evidence of tolerance.

we been been street by the
THC~delta~9, when looked at

In defining these patterns,

profile for
significance or the
from the vantage point of the hypotheses relating
behavioral response or drugs in men.
EEG

EEG

effects to

I truet these papers are useful.
Sincerely yours.

% ,1 4;, Amu“
a

Fiﬁ,
m
Professor of PSyehietry
,

MUD.

cc: T.

Itil

�</text>
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                    <text>“i, .‘

1.

w.—

“Wu”.-. vs.

\

,v,

un—‘WNHW, "mum-v.17...—

v.“ wavy“

r."-\‘-~»

._....‘--—..—...1w_V»..~im____ivv—w

Charlton
Contracting Officer, NIDA
5600 Fishers Lane
Rockville, Maryland 20872

Mr. D.

Re:

HSM

h2o70—98

Dear Mr. Kharlton,
we have completed the reports and delivered these with
extensive supporting documents to Dr. Steven Szara of NIDA,
completing the project portions of the contract HSM h2-70-98,
Study of Chronic Hashish Users in Greece. I am enclosing a
copy of a detailed letter reporting the status of the project
to Dr. Szara, indicating that we have been unable to complete
the data analyses of the withdrawal phase of the study within
this time limit. we are progressing with these analyses and
shall supplement our public reports with data from these analyses.

It has

been technically unfeasible for Professor Stefanie

staff during the last months of the study to
in New York. We have arranged for a major report on
the results of this study to be presented to the American Psychiatric
Association in May, and we wish Professor Stefania to make this
presentation. As we have indicated, there are allocated funds from
the contract portion of the study that remain unallocated at this
to send

one of his

work with us

time. We have requested Dr. Szara, and now ask your office, to
consider an extension of the time of the contract until May 31,
197h, without additional funds, to allow the presentation-of these
data at the APA, and such additional analyses as may be desirable to

be completed.
‘2'

SKEW'J

we;

January 28, 197h

'2’"

19:99.

,‘.

letter

an

Should

offer

this request be approvable, you
part of the Contractor.

on the

may

consider this

a
N)»

{mans-7.

.
,'

"*1€W_I_IK\€T‘P""'

”um,

may”

I wish to take this opportunity to thank you,

and your

office, and particularly Mr. R. J. Gradwell for their cooperation
in this unusual and interesting study program.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

�</text>
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                    <text>December 30, 1982
Prof. Dr. Helmut Kiinkel
Medizinische Hochschule

Karl-Wiechert-Allee 9
D—3000 Hannover-Kleefeld
West Germany
Dear Helmut,

Attached is a suggestion for an editorial for our new journal. By all
means, make corrections and additions. I tried to get the essential issues for the
journal, as I see them, in the last paragraphs. I also think it is a good idea to
separate our aims from those of clinical EEG.
"Work here is progressing well. As you may have heard, there has been
some political pressure, again in California, to stop the use of convulsive therapy. I
am busy defending this treatment, and particularly its continued research. Our
pharmaco—EEG studies continue, although a bit more slowly now that Mr. Irwin is in
Basie. I understand that there is a misunderstanding about our paper on placebo
effects in EEG. He wished to complete the report himself, and I hope that he has
done so, and sent you a copy in time.
My

best wishes for a healthy and successful 1983.
Sincerely yours,

Max Fink,

BALD.

Professor of Psychiatry

�</text>
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April 8, 1973
Mr. Lawrence Erlbaum

V.ﬁ. Winston &amp; Sons
1511 K Street N.W.
Washington, D.C. 20005
Dear Mr. Erlbaum,

Enclosed are a number of items: the corrected versions of
the papers by Fink, DYElie, end Volevko; two new reports (number:
21 and 22) by Kety and MoGeugh; edited pages 1 and 2 of the
paper by Ottoason (01h); end a discussion by Ottoeson to follow
paper number 1 (Fink).

I have made the correction: requested by the editor in red.
Note the comments vith regard to ’leucotomw'.'grend mal'; the desire
to use italics in my report; and a few other suggestions.
At present, there are two reports lacking: an overall summary
(paper 20) and an introduction. I shell do what I cen to get these

to

you

shortly.

Incidentally, I found your editor thorough.
many

m’

v";

thanks.
Sincerely yours,
“‘3’.

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                    <text>March 29, 1971
Dr. Sherman Kupfer

Associate Dean
Sinai School of Medicine
Fifth Avenue and 100th St.

Mount
New

York, New York 10029

Dear Dr. Knpfer:
We have been asked by members of the Ecunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment for opiate dependence.
We would like to cooperate with reputable scientists who may
contribute to our understanding of the opiate dependence problem.

I would like to assure you that the study has been endorsed
the Research Committee of the New York Medical College, that
it is undertaken in the facilities of the Department of Psychiatry
either at the Metronolitan Hospital Medical Center or in our
laboratories at 5 East 102nd Street: and that all precautions
which we deem necessarv for the protection of our nationts have
and will in the future, continue to he talcen. The amount of
heroin varies depending upon the need of the subject and design
of the exocriment. The amount varies from 5 to 75 mg i.v., usually
given in ch of Saline within 1 minute.
by

At the time that Drs. Puezkin, Aledort and Cutfreund visited
I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the complexity of the questions, perhaps
we should ask the assurances of the appropriate authorities at
me,

that: the protocol has been approved by the
of the Mount Sinai School of Medicine; and
committee
appropriate
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

your school

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>‘swew—

um‘wimwmvr‘ﬂm

wryﬂv...”

_,,_.V

AWN,

_

Twﬂw

,

March 29, 1971
Dr. Sherman

anfer

Associate Dean
Sinai School of medicine
Fifth Avenue and 100th St.

New

York,

New

$6?)
4

1:0

Mount

\

York 10029

Dear Dr. Kupfer:

f9

have been asked by members of the Mbunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment or opiate dependence.
We

would like to cooperate with reputahle scientists who may
contribute to our understanding of the opiate dependence problem.
If
I would like to assure you thht the study has been endorsed
by the Research Committee of the ¥“New York Medical College, that

We

it is undertaken in the facilities of the Department of Psychiatry
either at the metropolitan hospital Medical Center or in our

laboratories at 5 East lOanJMStreet and that all precautions
whichm deem necessary for the protection of our patients have
and will in the future, cohtinue to be taken. The amount of
heroin varies depending upon the need of the subject and design
of the experiment. The amount varies from 5 to 75 mg i.v., usually
given in 2cc of Saline within 1 minute.
At the tine that Dre. Pusskin, Aledort and Gutfreund visited
me, I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the conplexity of the questions, perhaps

we should ask/the

assurances of the appropriate authorities at

your school that: the protocol has been approved by the
appropriate committee of the Mount Sinai School of Medicine; and
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max
‘

,

—Tu

ups-In":- qwn’ " “ “any“.

Mszt

k

�</text>
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                    <text>May

25, 1968

Er. A1 meland

Spring

Guava

Baltim,

State Hospital

rhryhnd

DearAl:

Wandlwemwryplmodtomivemtmvel
of the Meal Society of Maryland, which Mrs. Wolim
111:th

mkindmghtosondusatymmmquost. metripiaindeod
mintemstingmoandmldbeaemsidmblesavingintim

“my.

Idomtthmk,however,tmtwecmtakeadvantage
States too
it will bring Mn back to the United she
has
that
Imdelighted
latetobeginhermpositim.
received an appointmnt in our sol-noel district as a first grade
of this since

teach-r.

Schoolmrtsfoermmtso,andweoamotsee

hareminghmtosurtschoolhte. Notonthefimtdnyof
lurfirstmjorjob!
,

ItmapleasmbeingwithywinﬂewYmk.
wards.

Mybest

Sincerely yours,
Phx Pink,

14.

D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>March 16. 1964

Br. Albert Kurland
Director of Raccarch
Spring Grove scat. Hospitll
Spring Grove. Haryland
‘

Dear A1:

invitation ta visit you to aliens: your
programs. There at: two occasions in the next ﬂaw months
when I will be in your vicinity. and would ha planted to make
I

an mindful of your

EEG

that visit.

,

I plan to attend the Spring Joint Compute: Conference. to be
held in Wauhington April 22 and 23. I have been aakod by
891 Goldberg to take in a site visit in Fblladolphla, and I
hgve suggeatad that I would do that on April 24th. It V0316
be poanible for an to visit with you on Saturday, April 25.
if that is a working day; or the aftarnoon and evening of
April

210

'

Alternately. Jon has called the next meeting of tha Clinical
Committeo for Nay 14-15. I chuld arrange ta vial: on the
afternoon of

'

free.

May

If

13. or the 16th, as both those dates are now

any of theoe arrangemnnts are convunicnt
be plcascd to include them in my prograu.
Hy

for you. I

would

boat ragardl.
Sincnrely youtt,

an: Fink.
Diractor
HF/jb

‘

H.D.

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                    <text>law;
i“ (Q1r1w53m

r
.

§+x

s

Am‘gdf'

April 10,

{WKKM ﬁr
1'

é“?

.

mtﬁtagoﬁ.

3.964

Dr. Altar: Kurland
Diractor of Rnsearch
Departmcnt of Mental Hygians

Stat: Office ﬂuilding
301 watt Preston streat

Baltimore. Harylnnd 21201
Dan: Al:

I thought I would sea you at the ECDEB meeting, but changed
my mind at the last minute and didn’t go. I am writing ta
confirm your kind invitation for May 13. If satisfactary
with you, I will arrive at Fricudnhip Airport on Flight #86
from St. Louis.
when Dr,LGild¢a asked me about blood

I could only think of

lavell of chlorpromatinn.

former atnociate at Hillside.
Dr. Goldcnbcrg. The problem with having a favorable reputation
is that occasionally it gets you into Iona difficult projects,
but I do appreciata your helping him. since the death of his
patient has baan a grant pumtle to the dcpartmont here.
Thank you

my 0

you and

for ya»: help.

and

my

I look forward to seeing
Sincerely youts,
Max

Fink,

Diractor
Mrljb

M.D.

you

in

ixi

cw-‘éﬁ-IWv‘
,

a};

,

'

.J
Aqua”. gig,

gtwﬁwg‘

�</text>
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                    <text>Juan 6 , 1966

Baltimore,

mum 21201

Dam A1,

Implmdtohawthaoppwtmitympartiaipauin

WWWWMtM. MIWWIM
mammamurmpmmwmrm
inrngpimtuinmﬂngmmmmingum
M
'

'

o

'

mummmmmmmmnm

amprdnt?

Sincerely yours,
Firm. PM).
m
Professor of Psychiatry

�</text>
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                    <text>Jammy

16 , 1967

Dr. Albert Kurland

Spring Grove State Hospital
Baltimore 28, Maxylami

DearAl,

Ianpleasedtoemloseaswnnarymportcftheresults

of the urinalyses carried out by our laboratories and
Mr. Kokowski.

overall data is quite complex indicating that there
in extraction and analysis which
contributed to the differences in ther-esults. While the
overall findings are that both laboratories concur in note
than two-thirds of the emuinetion, there me some potential
positive and negative errors.
The

are major differences

This data has been most helpful because it has indicated
to our laboratory and to my associates that some additional
clarification of our goals for such mﬁnalysés will have to

bemde,aswellassanechecldngoftheactuallaboratcry
s. Theseamnowinpmgressandwearevezy
grateful for your cooperation.
‘

Incidentally,
cost involved and

necessary funds.

we

never did clarify the question of the

if you will call me I will request the

IndmeddngtheNRCprogszorlexirgton,Iseethat
youwillbereportingmyourlaboratoryworkandIlook.
forwardtohearingit.
Mybestpereoxulmgards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc: Dr. Resnick
'

Mr. Kokowski

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                    <text>June 28, 1970
Dr. Albert Kurland
Maryland Psychiatric Research Center
Baltimore , Maryland
Dear Al,

It was a pleasure to visit your research center yesterday,
and I was very impressed with the progress that has been made
last visit a

since

my

Clint

Brown.

few

and you have assembled an

I

am

enclosing

years ago.

exciting

"s

“w“...-

that there are

.ﬂ‘m.wﬂ

you and

for

ECT

this instrument for quantitative

-v

reports for

With regard to the PDP~12, I would like to reiterate,
many programs that have to be written in order to use

.r‘r-p'vmn‘ri-A-

WG‘mWaN—umxﬁu?

and

very fine

project, I am sure that we will be
able to assist in the analyses of the EEC data, provided the information
is collected in a form compatible with our equipment. For Clint's
information, we have l/2 inch, Ampex SP 300 7-channel FM equipment.
As soon as I have a change
to review the protocol and obtain a
clearer image of the amount of data to be analyzed, I will be able
to submit a more detailed suggestion.
With regard to the

,,

reprints

some

facilities are

The

group of co-workers.

EEG

analysis. If the various users

ﬁéfiuﬁocéﬁdﬁeﬁiﬁé§ ﬁeeﬂﬁéﬂld be possible to obtain the services of
igédigﬂﬁtbﬁgcﬂdffiifeHﬁfﬁﬁpcﬂoC§H§f§t in the programming. In addition
ﬂo'tﬁd Eaﬁiﬂfﬁants listed in Don Klein's letter, I would be pleased
to have my associates provide you with a bid on the system that may be

useful.

3"”9 383 I630

My

thanks for your kind invitation and

hospitality.

.
.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>way-v.1

ww—u-

.m..,..«.—,.-...

..,

."w

"1w,“

__

&lt;

July 21,

1970

Dr. Albert Kurland
Spring Grove State Hospital
Baltimore, Maryland
Dear Al,

efforts at reversing the policies of Endo Laboratories
have been successful. Enclosed is a copy of a letter which I
received from Mr. Serchuck confirming this change.
Our

Having survived this crisis, I do believe that it may be
useful for us to continue our informal communication so that
we can be prepared to deal as effectively with future reversals.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                  <elementText elementTextId="101541">
                    <text>June 10, 1964

Dr. Albert A. Kutlend
Director of nenearch

Department at mental Hygient
Spring Grove state Hespttel
Baltimore 28, Maryland
Dear Alb“

I would be pleased to have Dr. Delamenice visit our laboratories
during the second week in July. we will, of course. make every
effort to provide him with accommodations. I must tell you, how-

ever, that the accommodations are in the main building of the
St. Louis State Hospital and these are rather warm for this time
of the year. I have tequested that one of the apartments be set
aside for Dr. Delumoniea and his wife, and if these are sutisfac~
tory upon his arrival, he will be free to use them.
Dr.

Ittl will be

do our

It

available during that period of time and we will
best to let Dr. Delamenica participate in our program.

was a

pleasure visiting with you.
Sincerely yours,
Pink,
Director

Mex

Klljb

M.

D.

�</text>
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                    <text>,

July

2

, 1965

Albert A. Kurlmd, Md).
Director of Relearch

upset-mm of Mutal Hygiene

Spring Grove State Hospital
Baltimore 28. Maryland

e.

v

"warm—w

Jr.

.*

our,

Dear-Al:

I was vexy pleased to remive your letter, as I think that
the convulsive therapy mdel has been studied too little.
As I see the convulsive therapy process, change: in brain
functim are a necessary. trough not sufficient condition for
iwmvcmt. 0f the various measures of brain fmction, changes
in the electroencephalogram seem to be the met easily quantified
and
sensitive available to us. Induced cmvuleiccs
the
produce high voltage slow wave activity in all parts of the head

ms

this can

m

easily measured.
The data indicates that in the absence of the development
of him voltage slow wave activity, behavioral change is limited

and

be

and appears with no greater frequency than in control gxoups

.

lhue, the principal predictive value of slow wave activity
line in the prediction that in its absence behavioml improvement
and in its presence, inpmvement may ocmr.
will not

cm

The principal predictors of the type of behavioral change
which we call improvemt, and mm: is gemmlly associated
with euphoria, denial, decreased tensim, immved sleep, 239'

are psymolcgical duraotezietice of the subject . Such
characteristics as propensity to denial. high degrees of
anthoritarimism, low discriminant ability are associated with

behavioral

WW”: when

EEG

slow wave

activity is induced.

third set of peremtere in the convulsive
therapy process having to do“ with the mintenanoe of behavioral
improvement once the physiological signs have returned to prettmatmnt levels. These may not have to he considered if the
study is focueeed on the short term treatment results.
There are a

�Dr. Kurland

July 2,

~2—

1965

Your letter reminds me that I should have codified our
convulsive therapy experiences many years ago but not having
done so, I met send wu a water of reprints which am enclosed.
I hope they are helpful.
As

to your kind invitation to visit with you, I

was

at ﬁrst

inclined to regard this as a gesture. I have thought about it,
however, and my interest in the convulsive therapy process has
recently been stimulated, not only by your inquiry but by a
similar inquiry from Dr. A1 Freedman. I have already agreed
to visit with him and to assist me of his students in a study
of conwlsive therapy. I would be very pleased to help you and
Dr.
I am very such interested in finding out if
models
our early
still hold true today,- and if your studies

133le.

can shed some light on those issms, I would be very pleased.
For this reason, may I suggest the following. I plan to be in
New York some time in July and can
arrange to come and visit
you in association with that trip. I also will be on vscatim
intheEastmringMgust.
spend
a few weeks at the bead), and I knw my cum personality well
«rough to anticipate a mstiveness after two weeks . Nothing
would please no more thm to com and visit you for a day in
mid-August.

Wmdlmplarmingto

I hope trace amounts are helpful and I am delighted that
you are undertaking a convulsive therapy study program. Good
luck!

My

best

rem.

Sincerely yours ,
Fink, NJ).
Professor of Psychiatry

Max

Hfﬂtp

�</text>
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                    <text>,

"'Ww'

mu»

~w-

'::nr,

‘

«v «nu—1...-

«a»

-

"on

.-'--

&gt;w—me- “rm-

,-v -.

.

-

.v.~.‘.-

—

..-r.-.—-.—r.~/.v.1.uw.

W,

,..

0

July 30,

1955

W
WMWW
,m&amp;”

ﬁ-D:
Am A.ofmm.
Rem-uh

m

“”32

“1

Dear A1:

Inmatemktmwﬂmlpunodmxtm
mmWafammwimmHmsidemtwhioh
mmm‘puhlilm. Ibeliewthisdatamybaofmm
mwmmmdmmwMthmftm-Wam
Ifxmviaitwuinmid-tugmt,1wﬂldo

Ww.
m.mmuyb¢ah1etodincmthiaaswllasthe
Iwmtz‘ymhringmmm‘dthm.

Sheena}; yams,
Max

14min

Fink,

91.13.

Profuse» of Psychiatry

�</text>
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                    <text>September 17, 1955

Dr. Albert A. Kurland

Director of Research
Department of Mental Hygiene
Spring Grow State Hospital
Baltimre 28, Maryland
DearAl:
The protocol "Conwlsive Therapy md Electroencephalogrephic
Change" interested as very such and I found much in the protocol to

it

contend
for study. Rather then describe some gemrelities,
perhaps the best I can do is to corrment on each of the sections and
then make some general overview cements at the end.

introduction and specific aims are quite clear and I would
omcur that such a study is needed. The specific aims on page 2 are
clear for a md b. Aim c is a specific reflection of Dr. Marshall's
The

interests , but he should be prepared to defend this since to my
kmledge there are no studies which have suggested that the seizure
pattern during a cmvulsion is significantly different either
depending on type of inducticm nor in terns of the therapeutic
result. There are some reports suggesting that there are chmges
in the threshold to induced convulsions and that these threshold
changes are related to clinical inprovement . However, to ask this
question would require omsiderable effort in anesthetizing patients
to the same degree of anesthesia and then detemining the threshold
for convulsion each treatnent. While this has been done for electro—
oonvulsive induction, I wonder if this is a reasonable suggestion for
Inddclon.

f

are mdmdsnt.‘ Aim e is a. good one but the phrase
"process electroencephalographic records" is unclear to me . Do you,
man the EEG records during each treatment?
Aime d and

Since the purpose of the program is to relate EEG changes and
belavioml response, and you are focussing on some predictors,
perhaps you would consider an wditionel aim to determine predictors
of neurophysiological response . I do not low if I have sent you a
copy of a paper that was never published in which we related some
of the pron-treatment EEG mmcteﬁstios and certain psychological
of induced slow wave activity.
test performances to the

mt

�up. Kurland

~2~

September 17, 1955

Havever, since you are measuring slow wave activity and will be doing
psychological tests , and determining the EEG characteristics in the
pro-treatment record, per'haps such a substudy would complement this

project .

Tm treatuent plan is also sufficiently clear. Hanover, in
the prediction of treatment response, there are significant differences
in the predictions in depressives and in schizophrenic subjects. The
rate of slow wave induction in depressives is generally higher than in
schizophrenic; and the behavioral adaptations to these brain changes
is different depending on the pre ~treatment persmality of the subject .
In our studies we tended to disregard the differences between
schizophrenics and depressives and I believe this has hurt our analyses.
By providing that you will be studying both depressives and schizophrenics
to indicate that the analyses should be done
it may be important
separately before the two groups with the anticipation that relationships between induced slow wave activity and clinical result may be
found in group and not in the other.
On page three the treatment paragraph brings in a new topic
mich is not related to the aim of the study program. There is
little evidence that the two methods of induction are different
with regard to the anomt of slow wave activity induced. Perhaps
an additional aim should be Specified to determine if the method
of induction does bear any relationship to the mmt of EEG
change and to the treatmnt result.
'

While the number of treatments (9-15) is adequate, in certain
schizophrenic patients the amount of slow wave activity induced on
a three times a week schedule may not be sufficient to have a
significant behavioral response . We have noted frequently that
such patients require more than 15 treatments and that often it
may be necessary to increase the rate from three to five times a
week. Perhaps a disclaimer could be entered into the treatment
paragraph indicating that if, after 15 individual treatments , the
anount of slow wave activity is less than 20% or- 308, the patient
will receive an additional number of treatments so that he has 20
and perhaps even 25 .
The inclusion of a three week post~treatment study period is
excellent. However, the evidence is fairly clear that this may not
be long enough. Later on in the protocol you indicate a six week
period and this is mch better. (Some studies have shown that the
amount of slow wave activity disappears quickly, but we have observed
patients in whom Slowing as still present as long as three months
after treatmnt. Equally inportant is the development of long ms
and high percent time alpha activity which often replaces the pro-—
treatment disorganized or desynchronized records.)

�Dr. Kurland

~3-

September 17, 1965

page four the evaluations appear to be adequate. The
psychometric assessments imply that you are going to reassess the
On

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role of c‘agﬁrm disorganization and memory change . The relation
between cognitive disorganization and mmry loss to treatment
response has been studied extensively and there is considerable
evidence that momory (arranges are often seen in patients who
favorably respond, but that the usual menory tests are too insensitive
to show changes in brain function. When these tests lave been applied
by sophisticated obscmrs like those in Sweden, the relationships
have been well documented. For this reason, I am not clear as to
why so much effort will be expendcd in this direction. However, I
would like to make two Specific suggestions which can augment this
battery. In our studies we were very much impressed that the
amount of slw wave activity was related to certain pm-tmatrent
psychological characteristics of the patients. The two tests that
mm most important were the hidden figures test and the California
F—Scale . Perfonnance on those tests was related to the amomt of
induced slowing. Homver, mom inportant from the point of View
of therapeutic response, the California F-Scale seemed related to
the clinical behavioml msponsc . The other psychological tests
did not show such a relationship. However, Dr. Kahn had developed
a denial personality inventory and this , when applied to the patients
behavior prior to treatment, was higily predictive of the behavioral
evaluation. We did not find this related to the amount of EEG
change, however.

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Thus, depending on the amount of effort you wish to make in
should be clarified and perhaps

psyclmtric assessments, the goals
two

sets of tasks included; those which may
wave activity and those that

mount of slow
inprovcmnt .

be

related to the
related to

may be

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to the EEG records, the section on baseline EEG
five, section 2 , brings up the focus of the
study coca again. Previous studies have shown that the mount of
slow wave activity which may be related to therapeutic
is
the amomt of slowing found between treatment sessions. response
is the
It
early dovelomsnt and mintenanos of high voltage slow wave activity
which has been shown to be related to therapeutic response . By
ouplmsising the EEG during the tmatnont itself, if will be difficult
to develop any parallels with other studies except during the posttmatmont period. At one time was attempted to measure the m;
chmges inmd‘iatoly postuscizurc and to relate these to the treatment
outccnm . In runny patients for periods up to one hour we found
oontimous low voltage one to three cycle per second activity which
was oomlatcd with the extent of post~soizurc confusion and.
disorientation. When those patients were recalled u to 6 hours
later, the mum: of delta activity was often
little , shaving
that tho patient had a very active Mmostatic very
mechanism and that
the induced slog wave activity disappeared quickly. For this reason
With regards

is excellent .

Pogo.

�Dr. Ktufland

4.4-»

'

September 17, 1955

in our studies

we took our EEG record 2» to 32 hours after an
induced convulsion. (Seizures were given on Monday, Wednesday
and Friday, and all EEGs were taken on Tuesday, Thursday, or?

A

Saturday.) To relate the present study to previous studies , I
believe records should be taken during the interseizure period,

amm‘ingthetreaunentcourseaswell..
Section 3 on page five is excellent and I

attempt wekly records up to six weeks minimn.
Page

‘

would urge you

to

six technique is fine.

Data analysis is unclear. If the purpose of the study program
is to corroborate earlier observations , then perhaps the mthods

used should be spelled out and described to indicate that you are
willing to undertake such ccnfimatim. If the ted'miques are new
ones and I believe that this is what you would prefer, then the
quantitative methods should be described in sufficient detail.
Nowhere in this outline nor in the supplemntary letter from Dr. Marshall

is the technique of analysis described except the visual. Now, I
believe the visual is more than adequate to accomplish the missions
assigned. However, if the recording on mgnetic tape and subsequent
quantitative analysis is to be done , then these methods should be
spelled out. In View of the present status of EEG analysis , I
mnder why you have not considered one of the analog analytic systems.
“more are two encellent ems, the pacer spectral density using GreyWalters original filter model and the period analysis . Equipment for
both is commercially available and while the Grey Walter system will
not give you frequencies below 3 ops with any fidelity, the period
analytic progress will. In either case, the reviewing group will
be very critical of such a paragraph on data analysis.
letter, I imagine he is considering the
eventual use of digital cmputem for the analysis of these tapes .
If that is so, than these methods should be described in greater
detail. Our studies are now being written in a form suitable for
presentation but we have described three different digital analytic
programs: the power spectral density analysis, period analysis,
and a random shapes sodel. These analytic methods are expensive
but we are mw analyzing tapes sent to us from Dr. Denber. If the
volmue of tapes provided by your laboratories is not too great , we
can, starting next owner, analyze sane of your tapes and provide
you with frequency spectra and period analytic spectra at different
stages for any or all of the lead cmbinations you may select. I
would recomuend that you include a paragraph in your application
stating that if you are given an opportunity to collect tapes,
that these my be analyzed by me assuming that this facility is
still operational at that time. (We are now mesmerizing the programs
that we have worked on these past three years and will ourselves go
to NIH for additional support late this winter, as our grunt support
ends October 1, 1956.)
Fran Dr. Marshall's

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September 17, 1965

Returning to page six, section a, the descriptims provided
are excellent, even though I would argue with the
"abmml". Somehow, the development of slow wave
in
activity
a post-seizure record is the normal effect of such
seizures and very much to be desired. The use of the word-"abnomal"
has a negative connotation which prejudices an observers view of
these changes.
by Dr. Marshall
use of the word

The section b on page seven is satisfactory since Dr. Marshall
has been identified with such analyses in the past.
Section c, page seven, can be criticized only as I did earlier.
The ten minutes follwing the post-ictal depression is not going to
be sufficient for the study that you invisage. I think this
paragraph should be rewritten after you have considered the need
for interseizure records .
‘

page sight, the suggestion that "the relative amount of this
activity after each convulsive treatment will be examined for
its utility as a regulating index for further treatment” is a good
suggestion. However, from my own experience , I believe that the
intemeizm record will probably be more helpful. However, both
slow

On

may be done .

section d on page eight is very important and my provide
a Special focus of your study. I would like to suggest that this
paragraph not onphasize the reappearance of the individuals pre~
treatmnt brain potentials, for this is higuly unlikely. What is
often seen is the development of incmased rhythmicity, higher
The

percent time alpha, and increased voltages which persist for many
to soothe . In those patients who fail the treatment and
who regress quickly, this rhythmicity is often lacking. A focus
on this period of time My be very valuable.

weeks

mwym

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The significance paragraph is good and I would suggest a few
additions . In the first paragraph the issue is the relationship
between the mount of delta activity in the EEG both during; a
series of convulsive treatmnts and after. It seems to me that
the sigﬁficance should emphasize the psychological and behavioral
tests which you are including. I would urge that the significance
such statements that some observers have indicated that
slow wave activity is an outward sigu that biochemical changes of
the brain have been induced and that these changes are persistent
in some patients and not in others. When these changes persist,
then the likelﬁnood of inprovement is high especially in patients
who have had ‘a depressive disorder and in whom the denial personality
is permanent. In those patients in whom these changes disappear

W3

quickly or in whom they fail to appear, the biochemical changes
in the brain are too weak to induce behavioral change or are transient .
The persomlity and psychological factors which may be related both
to the induction of high voltage slow wave activity and behavioral
hpmomnt of a persistent variety will be studied in this program.

�mmrﬂ

.
_

up. Kurland

'

-6—

September 17, 1965

paragraph mgaxding tape moomings is not part of
significance but rather part of the justification for special
‘Iho

equipmant.

\

Reviewing Dr. Mamball's lot-tor,

my continents

follow the

the original grant application.

comments on

The justificatim for an
I believe that if you wem‘ to

is not made clear.
for analog equipment to analyze
tapes or to analyze on—going records this would be highly commendable .
To record tapes in the quantity that you have requested is; also
a
mummdable suggestion, but for this I think his com-onto on page
two are sufficient. The mltichml memory device as a Nuclear
micago RIDL is too small for the operations which you envisage
and this is probably not, to be considered. With regard to tape
Incoming, the use of an ESP-800 even with 7 channels costs about
1$10,000 and this ohould be included in
your request, especially
you decide to include the possibility of having tapes analyzed
if
by my facility. You should he prepared, however, to indicate
the present program outlined includes 21 tapes per patient andthat
mat if both moment prooodms am to be carried out with
appmximtely 30 subjects in each cell, then a minim of €93 W00
tapes will be needed and since Dr. Marshall indicates that he
would like these as a library, the investment is approximately
a: cm!)
I haw no criticism of the use of krohn~hite filtem for these
are helpful for visual analysis. However, I thirk an analog analytic
system is probably to be preferred although you my still wish to use
filters for pmpmcccsing.
.

antpex Eds-100

ask

A

»

.

’

_

In reviewing the application there a nmnber of things which
omitted
and those are largely in the clinical ama. I think
an
you should suggest the numbers of subjects to be considered and
the rate at which you think you can bring them into your program
from your facility. Perhaps one should focus a little more clearly
on the decision making process mgarding umber of momma
because this will effect the analysis of the post-troaimnt 1368.
Setting nine mammal as a minimun is satisfactory, for depressivcs
but not for schizoohmnics. In either case , however, tho criterion
for clinical judgcmont should be described as either memory changes,
or behavioral immvemnt with msolutidn of certain symptoms or
the developmnt of a denial syndrome.
v

‘

‘

I review these notes, the program is a good one and I would
to 8% it undertaken.
As I mad these notes, I am indeed
sorry that I did not have
an opportunity to visit with you becauseinmch could be clarified
in a oonferexm situation. Nevertheless , I home these comnts
As

be plowed

-

are helpful.

&gt;

'

‘

‘

,

�Ir.

Kurlmd

~7-

September 17, 1965

I will and them out this afternoon and then call you
early in the week so that we can discuss this can the telephone.
My

best regards .
Sincerely yours ,
Fink, PM).
Professor of Psychiatry

Max

MF:kp

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                    <text>«wv

mwr—v-

wwi—WWF‘W'H-

,‘x/

Sepmmr 28,

1965

Dr. Albert A. meland

Dimotor of

Room

of Hmtal Bygone
Spring Grove State Hosp
tal
Deparumnt

.

Baltimm 28, Rowland

Bur Al:
I hm just-combat“ roadingthe second draft ofthe omvulsive
is clear, smcinot, sad I have fomd

therapy projeat. This draft
only a few
qmatims.

on

by

Wat

On page form the global
scale will be
the paydulattist. Insofar as diffemnt paydmiatrlstscowleted
respond

omfmim in diffs-mm: fashions , I believe a simple
psyd'loprmologlonl rating scale should be included
for tho
paydxiatrists. My om »
would be to use the IHPS
or am of the earlier Lam Scales, probably the forty 1mm mit.
Both will differentiate
Wing in a "Inactive”
dimotimduetooonfwimmmow
loss, mdthooagoingin
a "positive“dimction do: to
in psychopatMlogy.
Incidentally, the last line on pogo four should mad "...
omnt of induced slow wave ..."
to

immune!

tlm
WWe

Onpagaswmtheteamiqunisquite elm. Asevon dunnel
PH

magnetic tape

is woolly of

type and while the signal recorded

mtapoiomamlogaiml,
incurmwentimallmmwe
speak of the
on "magmatic PM
signal

taupe.“

In the laét paragraph the phrase "omtent in printing"

is

molesrmdthismybeatypcmmimlemr.
05pm thirteenthe fimtpamgmph is
mdin
addition to the qmstim written on the mo, Ward
the word "psydwlogioal"
should pmbably be replaced by the word "physiological"

as the process

involved.
are

has review of the

literatm,
am

raised by the
slgnlfioanoe.

the sigxificanoo

and the methods
few questions which are
mﬁwd and am not oovemd by the intmductim or
Why are you planning two types of induced omvulsions?

”oh quits clear. I

left with

a”

is unclear that these prodme different seizure
pat-toms or that the post~soizum 31w wave activity is the same
or different. it. is probably important for you to jmtify such a
decision, which, in women , doubles the length and expense of the
study. My own jmtiflcatim would be that the mempeutic results
While the evidence

�Dr. Kurland

~2~

'

Septemr 23,

,

1965

«—

mm,-«

.v.

..-

»-

1'.

have varimsly been reported as being different for the two tmat~
may be
was again, to confirm these

manta and that

it

obsorvatims in term of

Wile,
mmnt behaviaml

mad

mumphysiological

w—...wvm«.-..vw.—

”Tu-vw«'vu

-u

,
,—

“(gum/H

—.

“0;,

«WV

Ir-w

Saomdly, I note the omission of tha study of the seizure EEG.
In the review of the first draft, I tried to indicate that sane
balance might be achieved by studying the intemizum EEG (as this
has been found tabs related to treatment wtooam) and the seizure
EEG sine: this was a novel and probably inportant suggestion. Are
of the seizure EEG and its analysis?
to include
you
be
ulwuld
inclumd
in the dmft as a very important section
If so, it
precisely because it had not been mported in great detail before.

plum

Wing

It was a 91mm to talk to you

bum scammed
rental charges in our

discussion, I

mad

yam staff. After our

that I my haw misquoted the proposed
imtnllation. The present mental
mater
m
and
in the proposed unit, both IBM and
charges an $2890 a month,
CDC have grim us qmtatims of about sauce
per mth.

I look foward to this atudy mm I think is a very interesting
mdinportmtmn, mdwillbogladtbgooveritwiﬁayouingmater
detail in (Emmett-wt. next
My

mm.

best magma.
Sincerely yours ,
that Fink, 24.1).

Professor of Psychiatry

Hfﬂcp

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                    <text>Navember 28, 1965

Dr. Album: A. Kurlmd

Director of Resoamh
Department of Mental Hy iene
Spring Grove State Hoop 1:31
Baltimore 28, Haryland

Dear Al:
Hay I take ﬁxis Opportunity to thank you and Hannah for your
wmdarful mapitality. I enjoyed the 0W3 very
and I
must also say that I was impmsed with the facile technique
convulsive
.

m,
Wamhiday

mmamme

'

Drain; the omfomnce, I had the opportunity to have dimer
with Dr. Russ mums and Jmaﬂ'nmz Gale. Knowing Russ '3 interest

in amvulsiw ﬂumpy, I told him of the temniqm whim I had
seen at your unit. Jmathan bxmght up your study and the extensive

activities of Dr. Marshall became a axmject a! discussion.
I in enclosing a mviaw of eholiwgic mchanisms inroonvulsivu
mmpy, mien I had written 3m years ago. Your application
stimlatcd me to mdmft this copy and submit it for publieatim.

Iwmldbegmtafulifywmuldpamitmtosceampyof

yourmportoncombineddrugs.

I

look forward

to seeing

you and Hannah

in Puerto Rico.

Sinmrely yours ,
Fink, PM).
Professor of Psychiatry

Max

me.

�</text>
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                    <text>,\_j

January 21, 1966

Alba-t A. Kurlend,

Wt

M. D.

Director of Research

of Mental Hygiene
State ibepital

Spring Grove

Baltimore.

Miami

DearAl:

Myouvewmhfcrmkingmmmem‘ipt
of motel}; Ill Patiwts"

"Oombimd Drug Treatment

aveilsbletous. Wehvemeditwithagveatdeal
of intereet, and despite your cannents at it length
and statistical interjections, we found these interesting
and valuable. As with our mm study, the princioel
mestion mich is in the forefront is the influence
of dosage on these commutims. In this study, the

Wine-MW
scores, differemes
also

combination showed” in
from the chlorymeine—

many

Wim-

placebo oombinetim and
ctdordiasepoxide. The problem with seeking levels

of significance from this data is that the best
dosage combinetion my not have been achieved, and

mg

the variability
the patients is sufficiently
meet so that even in powletions of forty subjects,
the differ-ewes do not achieve the statistical
differences remixed However, the fact that
ine-imipmmine arms changes in some
'pswmpBWlogioel symptoms while the mimtion
of cﬂommzine and cﬂomiaaepcmide is often
mtably poorer, provides belnvicml clues which
are mistant with the eleommphio effects
noted for moh contimtime.

I

m

(2121sz

the observation that
sewed
wipe-amino
better in those with high
depression scores. high retardation scores, and
low

agitation of west interest sime this parallels

the moontmlled obsmatime mien were carried
mt at Hillside I'bﬁpime

�Answer obsmetion which seem

is the differences

Went to

me

sales and ferrules. Them
have been many suggestions that female patients are
more semitive to mmiszims and wibit pukimonism
bah-ween

earlierendetlmerdoeeges. Iknmefewstudies
mmmmﬂwdosegewes muslledeooozdingto
body weight. Also, in e numerof mlyses of the Hillside
Hospitaldate,ﬁm££6dw\gesinduoedbyohloxpmzim,
when the clinical effects have been shown different for

by imi‘prmim were different for males and females.
Quack Hell,
with Dean Clyde. mdertodc the analysis

md

mm

sth that
higher

of the Hillside Hospital 1959—1952 data and
the W1: of bets activity pmdmed in resales

'

was

ﬁnanthetinneleson‘memdmgdosage. Withthisin

mind. the diffenemee might
physiologioel factors, even
'

stillbe related to neuro—
if Megs were omtmlled.

I also found of interest you" observation tint
chlorpmemim and placebo was sueoessful in the
alleviatim of retardation . This also is consistent
‘dﬂammmobservartions mdlbeliewthis is mother

Wasteinthismpon.
‘

Inyourmvisimofﬁsisdmft.peﬂmpsﬂxefocus

owld be plead on the clinical obsemtiorm , simly describing
the unmade used and omitting the extremive dismssion of
mﬁwdolo‘gy and uﬂmdolegioel problem . mass are

Wmm,buttheusmlmderemintemtedinthe
clinioalduteam. Ithiﬂcﬂmolinicel detais

W1:

very

clinical data presentation should
the
in
wbliehed
I’m ives or the Austrian Journal of
3:
We

and surely a

have begm the analysis of a group of schizophrenic

patients who have been pleoed serially for eight week periods
on placebo. mlordiazepoxide slam (1 tug/kg), ﬁxioridszim
alone (5 tag/kg) and the ombimtion using half strength of
each. Dosages were fixed. and the evaluations were done
during the second four week period. The patients were
long-term emiaophrenio subjects and all male. A copy
of the present. revised date malysis sheet is enolosed,

madthie

willgivemepieturemtwermheve.

meoxide

Itis

of interest to us that
alone was not
sigmifioenﬂy different than phoebe. But the smell mm
edded to a mu dose'of thioridazim was sufficient to

pmdmesignifiemtdmges inallthemtingsystem.

This, we believe, argues for an mutation of the
thioridezire effects by chlozwdiezepoxide . As you can guess,
we are now involved in the further analysis of the individual
items, and in ﬁne EEG relationships

�mummy mﬂwksforﬂwoppomdtytomdm

IdoMpeitwillbepublislwdsom.
m. but
mm.
ﬂy

Simmly yours,

Max

ijmh

Pink.

M.D.

Professor of Psychiatry

�</text>
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                    <text>Earth 1, 1066

W

W
W
Balm, mm
Spring

of

Hygiono

State Hospital

mm.

In the curly development at the ECIEU
the
Clinical matinee mmndnd approval of prom,
a pmjaet ”EEG

W
m

wﬂmhydnptmmhgy,”mmmmﬁwdsofm
in gamma? and psyahm
Myst: both for the

m

prom
in general. In sow of the early stwiies,
omwntiml anemic freqwmay analysers mm applied to
treatment assessmta However, the principal focus
since men has been an evaluation of digital mutter
-.

mthods.

I mplaased t0 maxim

act-any

ofammmal Warming

thedigimmrterpmmwmoftheappncatm
wwwmiwmwmthepastmwym.
A

second, shaman text presented

at the ma:

IBM

in October is also enclosed. This
men
of
the material of the larger.
swims
mesa reports will maxim: you with our pmgmss.

Medical Symosiwn

Sincerely yours ,
Max

Fink, Md).

Professor of Psychiatry
Wzkp

�</text>
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                    <text>20 Hatch 197&amp;

Edward

J. Sachar,

K.D.

Departnnnt of ?syeh1a:ry

Hontaftora ﬂoapttal
111 East 210th Street
Etonx,

New

York 10667

Dear Ed:

Charlia has told

me

of your accepting chairnanship of the
Congratulations!

1975 APPA Program Connittae.

During the past twa years, I havn became intareatad 1n the
affects of burnout: on brain function. In our studio: I haw:
became acquainted with tag scientists from abroad who I would
like to command to you for consideration in the program.
David dn Wind, M.D., Protaaaor and Chairman of the Depart*
nant of Pharmacology at the Univnrsity of Utrecht, has bean a
vary signiticaut peruon 1n assansing the role of peptides in
unwary function.
Hank van Biasen,'m.n., is 00G of his atudenta, who has bacn
taspanniblc for the pharmacologie aaaaya of paptidas derived
from ACTH. He works at §.V. Orgaaan, Gas. Holland. Both of
those nan speck excelluntly. and should you teal that a preacn~
nation from nicks: of them would be useful, I an optimistic that

they

will participdta.
I am also sure that

you are acquainted with tha recent work

affocts for a variety of

of Turan 1:11,
sex hormone: and their antagonists.

who has demonstrated cus

Again,

my

congratulationn, and

my

bus: regards,

Sinderaiy yours.
Max

MF/cin

Fink,

M.D.

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                    <text>19 March 1974

Edward (2. Sunny. M.D., Ctr-Charm
Drug Abate Coutctunoa
Hhacun of Scinnca and Industry
57th Strcet and Laka Shore Drivu
Chicago, Illinois 60637

national

Dan: Ed:

I vary much rcgrat that I will be unable to att.nd thav
Racianal Drug Abuna Confsrenca. as I am schcdulod to ha in
Europe

at that tins.

I havn no roservntioas 1n ruccmnanding my rcpllcsmnnt at
tho ﬂaw tart Mndical Collage, Richard Rennick, M.D., to subotitutn an my behalf. should you approve, yea may reach him
at (212) 369~7900 or (212) MDZ~1899.
my

best wishes for a succauaful conferencn,
Sincarely yours.
Mn: Fink, M.D.
Professor of Pnychiatry

M?/ois

�</text>
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                    <text>October 3, 197h

Sylvie Levin,
Th Round

Hill

R. N.

Road

Roslyn Heights,

N. Y.

11577

'

Dear Ms. Levin:

I have not worked with nicotine, nor do I have suitable
references in my library. There has been a volume on nicotine
published in a series by V. H‘ Winston and Sons during the past
year.
The only scientist that I know that has been working
Dr. Murray Jarvik, who is at the V. A. Hospital in
Brentwood, California. You may wish to write to him regarding
the evidence for dependence on nicotine.

actively is

Most useful may be a letter to the NIMH Information
Service at 5600 Fishers Lane, Rockville, Maryland. They have
materials which would probably be the starting point in depend—

ence on nicotine.

It is interesting that you have raised a question which has
not been studied in my Lab, and I regret that I have no personal
experience with the problem.
'

"rm—m,

w

Sincerely yours,

w"

‘1Iﬁm.\rﬂ'7‘

,..._.,

any,"

“ml

t

.w'

Fink, M. D.
Professor of Psychiatry

max

“rm-WW7,

Mmzed

'

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                    <text>May

We“

LI

KWM.

2,

1966

“‘DI

Assistant Professor
Dapamnt of Fsyehiatry
New Jemcy Collago of Medicim and Dantistzy
2“ Baldwin Avenue

Jersey City,

M

1!».

York

New

mm:

W

Thank you very moh

for yam kind invitation to participate

in tha posh-Waite
of the New Jersey College of Hedicim
and Dentistry. It was kind of a». Dahlb'em ta mammal w
participatim. and I would be pinned to make whatever attribution

I can.

subject of the

gamma].

and specifically. the
nemphysiologiml activity of 1.31) and mum 3&amp;1).ch is
one that has been of midemble interest to me am! my associates
The

forﬁwmt ferayeam. Iwmldbeplamdtodmmsmwork
(What's.

and the available

studiesby

Effective June 1, 1956, I will be at the NW York Medical
College. This will make: my participation bath easier and much

less expensiva.

My

We. will ha:

meesaar of Psychiatry
Departmnt of Psychiatry

NW Year-k

Meal College

5th Avem and 106th Street
Maw Yak,_Nm Ears: 10029

Thank you once again

wishgs in a

amsaful

for your invitatim and

mm.

best

Simmly yam,
Fink, NJ).
Professor of Psychiatry

Max

Hfzjm

my

�</text>
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                    <text>SlptOlbﬂr 12. 1966

Dr. Horton L. Rnrland

Assistant Professor
nqpartnunt-ot Paychintry
new abrtay Colloq- o! ladicinc and Dantistry
24 Baldwin Avunu.

Jittoy City.

New

abruoy 07304

Dear Dr. England:

for your letter of BIPtIIhOt i. I an
writing inundiatoly to indicato that tho data lcloctod
in tho period for tbs anotiugn of thn Annrican Colloqo! unurophnr-ncoloqy. I an sensatiod to prqparo a
rcport for that tinting whidh in plannod for choibor 6
to actuate: 19. I! the 0th.: participants are alto
interootod in payahapharnncoloqy. thcy Iny alto indicntu
their dusirc to h. it this national uniting.
Thank you

know

1! tbs data runninl on Doccnbcr 7. I will
it in pousibic for In to attcnd.
Thank you for thy invitation.
Sinccroly yours.

whnthcr

rm. “On.
m
Protolnor of Psychiatry
”310’

let

you

�</text>
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                    <text>September 16 , 1966

Dr. Morton L. Karland,

Assistant Professor

Department of PsyChiatry
Jersey College of Medicine and
24 Baldwin Avenue

New

Jersey City,

New

Dentistry

Jersey 07304

Dear Dr. Karland:

I have called the Chairman of the session of
and find that I an scheduled to present some
our observations in Puerto Rico on December 7 and
It would not, therefore, be possible for me to be

ACNP

the
of
8.
in

Jersey at that tine.
I will be back by Decenber 11, and should be able
to participate any time within the next two weeks.
Thank you once again for your kind invitation.

Rev

Sincerely yours,
Max

Fink. H.D.

Professor of Psychiatry

�</text>
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                    <text>November 16, 1966

Dr. Pbrton L. Kurland

Assistant Professor
Department of Psychiatry
New Jersey College of Medicine and Dentistry
2“ Baldwin Avenue

Jersey City,

New

‘

Jersey 073m

Dear Dr. Kurland:

—

In reviewing the proposed announcement of the "Symposium
on Psychedelic Agents ," I can only ask that the title of my
presentation be defined a little more clearly- Would not
"Psychophamxacology of Psychedelic Drugs" be a better description?
more precise
or Dr. Dahlberg favor me by being
Am
wish
I correct in
focus
topresent?
with regard to the
you
wide
of agents
the
wish
enphasize
range
to
assuming that you
of their
the
cmnalities
which have hallucinogenic properties ,
abuse?
of
and
the
problems
central
and
effects,
neurophysiology
LSD
alone?
be
on
Or, is the focus to
Would you

Sincerely yours ,
Fink, M.D,
Professor of Psychiatry

Max

m‘f

‘cc:

kp

Dr. Dahlberg

�</text>
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Kr. I.W. Karts.
The

llus

Jr.

Lino Chnuicsl Company

302 south Irosdwsy

8:. Louis. Missouri

63102

Dos: Mr. Karts:

I

would bs plossod

if

you would wake up tho Impulss of

stropins as discusood in your letter of usrch 12, 1965.
Sinceroly yours.
Fink, M.D.
Professor of Psychiatry

Max

31:1:

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                    <text>April 2,

Mr.

I.

Kurtz,

W.

Jr.

Meal Ooupmy

Blue Line
302 South Broadway

'11-»

St. Innis, msouri

M

Mr.

1965

63102

my}:

Atﬂmtﬁmwminquirdngfwﬁmpmmctimof

momma Atmphn Sulfate Solutim,
with SKY laboratories in Philadelphia.

I raised the

miletlnymmmblotopmdmetmwppnea,

mtmtad

problem

they

solutions.
m an malyaia of amh
information.
am
If this is of
I enclosing a copy for your
of
firm,
in
the cumletim
our roqmst,
if not,
any halp

have sent

plum

destroy

it.

Sincerely

yum ,

ﬂax Pink, H. D.

Professor of Psychiatry

�</text>
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                    <text>August 9, 1968
Ma. 1. w. Kuntz, la.
The Blue Line Chemical Company

302 South Enoadway

St.

LouiA, Mibbouni 63102

Dean Mn. Kuhtz:

Thank gnu veny much 604 youn pnompt and most uAe5u£ nepﬂy.

I do not know how we miéaed théb item not how the phanmaciat
did, but we axe abze to obtain the amputea 5aom E££ titty and
thia udlz indeed make can paoject ﬁeaaibte.
Many

thanké 50a youa heﬁp.

Sinceaeiy
Max

Fink,

younA,

M.U.

Pnoéebaqa 05 Péychéatag
MF:kp

�</text>
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Ms.
The

Natalie

S. Kurtz

Psychiatric Institute

University Medical Building

2141

K

Street,

N.W.

Washington, D.C. 20037
Dear Ms. Kurtz:

All we will need for our presentation at the Psychiatric
Research Society is a slide projector. Uur slides are regular
2 x 2”.
.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>m

ermam'-.—.w_—m.w
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March 2, 19Th

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E
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'5

Philip

Bookmsn, M.D.
Hermann LsRoche, Inc.

Rutley,

New

Jersey

E

§
E
y

Dear

Phil,

3?

¥

I very much enjoyed our discussions on Thursday, and I
thank you for the invitation. The final report on thebe diszepnmcompleted
bromszepam-plscebo EEG and bloodllevel study should
the end of the mbnth and sent to you.

by

In checking my files, I found the enclosed report by Dr.
This report answers some of the questions raised about the
Itil.
evaluation of thymoleptics and antidepressants by neurophysiologic
methods. I spoke to him and he was pleased to have me send you this
copy for your information.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

�</text>
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1

M

E

0

M

March 1974

R A N D U H

To:

Marvin Kuschner, M.D., Dean, School of Medicine

From:

Max

Subject:

ADA

Fink, M.D., Professor of Psychiatry

appropriate, if it has not already been done,
for the School of Medicine to establish an AOA section. ADA
has been used as an incentive for excellence in study in other
institutions and may be useful here as well.

It

may

be

If not yet established, perhaps your office could inquire
of the faculty how many are already members to determine if a
sufficient nucleus exists for the development of such a unit.

MF/cis

IIIIHIIAL‘

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w,,_—...,__~.

..,

_...,,,,,.,.

aura".-

m

~&lt;forvn1x

—uu-

April 1h, 1975
Dr. Austin H. Kntscher
630 west 168th Street
New York, New York 10032
Dear Dr. Kntscher.

for your invitation to submit e manuscript on the
use of andipsic drugs in the dying patient. I regret that I am so
committed that I cannot take on this assignment.

I thank

you

years ago, at s eeting on narcotic analgesics in
eckitt and Colman, Hull, England,
described studies with a highl potent analgesic; etorphine, which
seemed useful in patients with terminal cancer. You may find reference
to his work in: Kbsterlitz,ﬁ., Collier, H. 0. J. and Villsreel, J. (Eds. ):
Agonist and Antagonist Actions of Narcotic Analgesic Drugs, Loneonx,
Some

Aberdeen, Dr. Gareth Blane of

Macmillan, 1972.
uyr!

mm.

If

contribute

he hesnmninteined
to the symposium.

his interest in the topic,

he may wish

mm

Sincerely yours,

w

mmrcm

‘fx

"‘5.”

Fink, M. D.
Professor of Psychiatry

Max

‘

MF:ed

bcc:

«rm

vzscW-uwmsv-

V

\

Dr. Gareth Blane

to

�</text>
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Dr. Austin H. Kutscher, President
Foundation of Thanatology
630 ﬂoat 168th Street
*

New

York, N. Y. 10032

Dear Dr. Kuraehar:

for your kind invitation to prepare a position
second
conference. I ragret that I cannot accept
for
the
paper
Thank you

‘8

my

prior comitments are

Good luck

too: heavy.

in the conféronco.
Sincerely yours,
ﬂax Fink. H. D.

�</text>
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_-..~o‘

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m:
mom:

mutiny 1. You“.

»

.

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m Max. am.
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(smtmhad lit-t)

M/ 13

m.

BM).

mm to:

1‘1

hbontoriu

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LnCmcha Hotel
Pusrto Rico

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inauppm't ofmsethionmadebym‘. Momles inbehalf
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                    <text>,_

mey

2%, 19618

Dr. Paul Lacy
Department of Patholog

University
Hashim
of Medicine

Sdmol

660 South Kinghighway
81:. main. Pﬁssmni

Dear Dr. Lacy:
Do. James 8. Nelson, who is presently on your staff. has
plied for a position on the research staff of this Institute.

This

Institute is the

ap—

the Division of
mam water of dedicatedto

mauseasesofmesmteofmssourimdis
studies of
the severe

many ill.

I would be mum]. for your opinim regarding Dr. Nelson's
independent research, his ability to get along
to
me: any sumstions regarding his interests in

mm
Wm,
teaming. emofmwpeotsofﬂzepmmmofthislmtituteis

capacity
with his

in the mining of .psydxietz'io residents. and we are plowed to consider Dr. Nelson as part of the tawny.
Thank you

for your ooopemtion.
Sincerely yours,
Max

Fink,

Dimotor
MI-‘zmlg

M.

D.

.,#"

�</text>
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                    <text>“rip—w»

n...

--

,

I‘KIVYVHVF‘4‘WJ“.

.

«v- -.

vrrwv,» q—w‘, Awfw\«

("f-S. ti”‘;.mm'-Ir_-u—xmw'ﬁ'.
"Wz'rs; v..."

May

25, 1970

Dear Dr. Ladewig,
and

it is

final details of the CINP symposia are now completed
understanding that you will present a report, Amphetamine

The
my

and Hallucinogen Dependence in Europe, as a joint presentation with
Dr. Battegay.

I am enclosing the application forms for registration
at the meeting as well as the formal acceptance of your report for
the Program Committee.

Please note that the Committee has requested a written
for
paper
publication be submitted at the time of the presentation.
I would like to accommodate the Committee and am asking each of the
participants to cooperate.
I lookeforward to your presentation and to meeting
in
Prague.
you
My

best regards,

and

my

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Chm,

mf/

Session 4,

CINP

�</text>
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                    <text>April 26.

1972

Dr. D. Ladewig

Psychiatriacha Universltatskliaik

£056 Basel/Schweiz
Wilhelmvxleln—Strasso 27

Basel, Switzerland
Daar Ladewlg:

I will be pleased to see you in ﬂow York on May 10. Please
office on May 9, (121—369~8488). 0n ﬁay 9, unfortunately;
call
be
out of town but I shall he in all of May 10.
I will
my

New

I will be pleased to-haﬁo you

York Modical College, 8 Floor.

will participate in our discussions.

Ry

visit

our laboratories at

cowworkor, Dr. Dan Volavka,

Sincerely yours,
Hat Fink,'ﬁ.D.

Professor of Psychiatry
Mfzig

�</text>
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                    <text>October

21+,

1966

Dr. John Laidlaw

Medicil Research Council
EEG Unit
Western General Hospital
Edinbm‘gh, Scotland
DearDr. Laidlaw:

recent Proceedings of the HEB Society of October 30,
indicated your continued interest in quantitative measures of
EEG. I recall your applications to changes with liver disease
and would be grateful for any preprints which you may have
available for other clinical applications. Your suggestion
that the MDF is most sensitive in clinical correlation is of
interest. In which studies in addition to the cardiac operations
has this been true?
‘I'he

Msnytlmnks.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Mex

MF:kp

�</text>
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                    <text>L7:

in:

‘41::

“1

November 20. 1970
The Honorable Melvin R.

Secretary of Defense

Laird

Washington, D.C.

Dear Secretary Laird,

Reports of increasing use of drugs and deaths from opiate
use in Viet Nam prompts me to bring to your attention the enclosed
studies of opiate antagonists. These agents provide a logical
prophylaxis of opiate dependence but do require additional

research effort.

contracts are

now

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

enc

o

eb‘mx.;::~:

its“-

,2,

in progress under New York State
would
be
useful for the Defense Department to
auspices. It
view
towards supporting, encouraging
review the data with a
or undertaking efforts in this development.
Some

.4}.

"tat-ti:

VJ.

ww-

,.

�</text>
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                    <text>7383~639

April 26, 1973
$0:

Arik Brisaennan. H.D.

FRQM:

Nix

rink.

M.D.

aunJECT: Viﬁ Drug Dupendenae ﬁrentnent Center: Opening

of ndbulatory treatunnt programs

The Dare, outablishnd in July. 1972, first developed an
inpatient treatnnnt unit with «aphasia on the grentmnnt of
opiaxo dependent vutcrnns. ‘Effﬁﬂti?! Ayril 23in, 1973. the
name

is

new oxp¢ndin5

it: program

fully ambulatory basis.

to trett

auch

patient:

on

s

(a) aggggitien awnilnbla.
The staff naw offers intoxirication. psychiatric
counselling, group thcrupy and vocitienal counselling. mathndone

and lavamathadyi unintenanca. and dcaonditioning therapy axing

eyelalocinn.

to the

DDTC.

On

Thane

services urn afterad to patients admitted

a fully ambulatory bani: tho

DDTC

will accept veterans

tar adbulatory detoxification, induction in

nathndone. psyuhistric
and vuontionnl eounuelling, and genial can. work.
(b) Admisaian ggggegpro.

to the

Vctaranu may be ancaptea to thc progran.by application
at ﬁbrthyort, by calling:

V13

or.

261-hhao x 22h? (Dr. Brissendcn)
269—6600 x 2285 (Dr. amazon)

Paticnts will be such by a phyiieian, and an anaesumnnt
of their drug depandanny made on the basin of history. physical
examination. and, where appropriate, urine sunny and nalaxonc
(or nnlarphine) challango. Admission to outpatient or inpatient
pragrun will be maﬁa by the admitting physician.

�</text>
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                    <text>January 14, 1972

Lal, Ph.D.
University of Rhode Island

Mr. Harbans

College of Pharmacy
Department of Pharmacology
Kingston, Rhode Island

&amp;

Toxicology

Dear Dr. Lal:
Thank you for your kind invitation to participate in
the volume, ”Drug Addiction w Experimental Pharmacology.” Our
data, relevant to the interest of your readers, was presented
in 1971 in Clouet's volume. As tne results of our ongoing
work are not yet in a form that will allow publication, I re—
gret we cannot contribute to your interesting volume.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig

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                    <text>....;..,

~.-

..

,

“r

‘r-m

.

,

"w—"4—,. Yaw. my ...-..—_—-

WWW—wrun—

'mu'r“w

mm...r&lt;—~..~v,.

..,...,.&lt;

.,.

.myqu-w-w-w—u

.mwuwnu-v...

April 5, 1973

a...

"W

Ms.

Carolyn

Patient

Care

Lamb

Darien, Connecticut
Dear Ms. Lamb,
Dr. Kaiser makes an important complaint; one that is
shared by many other professionals, the-laity and the media. Are
the presentations in the 197a New Yorker article with its emphasis
on permanent brain damage, or the 1976 article in Psychology today
which suggested that BCT 'burns the brain', or the image in "One
Flew over the Cuckoo's Nest" correct ? Does ECT cause permanent

brain

damage ?

Dr. Kaiser also laments its unequal use in populations, its
alleged overuse and abuse, and the thorny issues of consent. In raising
these questions he is not alone, for since 1972 there have been numerous
individual assessments of BCT, conferences and symposia, and at least
three international task forces reviewing the questions. There are
some answers.

has been shown to be the most effective treatment
for severe depressive illnesses and for catatonia. The results in these
conditions are consistently better than alternate treatments. ECT is
also useful in mania, but the comparisonnwith lithium therapy is
lacking. In schizophrenia, the evidence is also clear, that ECT is no
ECT

better than pharmacotherapy,

and should only be considered a secondary
treatment. In the neuroses, adolescents and children, cases of
psychopathy and addiction, ECT is of no value.

As to safety, it is surely as safe and often more so than
other treatments for the mentally ill. Suicide rates and death rates
are consistently lower for ECT treated samples. The old complications
of panic, fear, fracture need not occur under modern regimens. The
principal complaint is still amnesia, but even this can be reduced
markedly by the properttreatment which should include anesthesia,
muscle relaxation, oxygenation, and proper attention to the use of
minimal currents and unilateral non-dominant placement of electrodes.
Under these conditions, the incidence of persistent amnesia should be
less than 1/200 cases, and even when the complaint persists for some
weeks, should be reversible within six months.

�.

-.-

mt.w..ww.

as". v...

.

~—

“when“...W‘WWWW—evv.mwv w. Trips... vw'm. .wmwwwnramlm -7“... .,__._,_.,._...._...._
.

m

“wuwr ...._

._...

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...__

.w

.

.

,, ,

is a question about training in ECT. Host physicians
entered psychiatry in the last two decades received little
training in HOT; and the older clinicians, many of whom learhed the
techniques in the 1940's and early 1950's, may still be using techniques
that are clearly outmoded. It is important that ECT training sessions
There

who

be made a regular feature of medical review courses and that only
physicians with recent experience be encouraged to use ECT.

Contrary to Dr. Kaiser's opinion, BCT is a treatment of
and
the middle
upper classes. In the APA survey and our own in
New York City, we found that university private hospitals treated

-

“a,"

'(‘V'Y‘W‘mw’rlnmn

_.

..._

-

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my

about 5% of their patients with ECT; private for profit hospitals,
with middle and upper class clientele, about 30%; while public
(minicipal, State and VA) hospitals used ECT in less than 1% of
patients. If anything, the complaint should be that because of the
expense of HOT, and the prevailing reimbursement policies, ECT is
a treatment that is reserved to the insured and the self-payeing

public.

Consent is an important issue. There is little reason not
to treat the voluntary hospitalized patient who is willing to be treated,
after a reasonable explanation of the risks and benefits of the
treatment. Also, there is no problem in NOT treating the voluntary
patient who refuses ECT. The issue in involuntary patients is more
complex and I would refer the reader to the APA Task Force report
for a better discussion of the issues and the recommendations.

of the technical questions would require a
text—book or manual, and I am pleased to tell him that two excellent
manuals are in press, and should be available by the end of the
year (see below).
The remainder

ung-

'1

nnmpmrw

WWI-tn.

1'4"”!-

is

"WI-Urn

_

Dr. Kaiser is to be commended for raising the question. He
fortunate to do so at a time when the assessments have been made and

are available. He should also know that the mode of action of BCT has
received much intensive study, and that so much is known about the
process, that it is likely that a biochemical equivalent of the
BCT process should beiin the clinic before the end of this decade.
I

commend

the following articles to him:

R. and Prange, A. Convulsive therapy and other biological
treatments. In Flash, FF and Draghi, SC (Eds): The Nature and

Ilaria,

Tﬁeatment of Depression, New York, John Wiley

Efficacy and Safety of Induced Seizures
Comprehens. Psychiat. 19: 1—18, 1978.

Pink,

H.

8

Sons, 1975, pp 271-308.

(EST)

in

Man.

Frankel, F. Report of the Task Force on Convulsive Therapy, American
Psychiatric Association, Washington, D.C., in press.
Asnis,

Saferstein, S. ECT in Metropolitan New York
survey of Practice, 1975—1976. Amer. J. Psychiat.

6., Pink,

Hospitals:

A

M.

and

135: u79-u82, 1978.

,

�—‘._..,

.

,

"'Wrwq'

v.7,

a-

.w w“.

W quwmvmwmmwawK—‘F'm

7.“,—

Psychiatrists Memorandum on the Use of Electroconvulsive
therapy. Brit. J. Paychiat. 131:2II-272, 1977.

Royal College of

Pink, M., Kety, 8., McGaugh, J. and Williams, T. The Psychobiologz_
of Convulsive Therapy. Washington, 0.0., V. H. Winston 5 Sons.
197u, 312 pp.

Convulsive Therapy: Theory and Practice.
Press. (late 1978).

Fink,

ECT

M.

is alive

Perhaps the

New

York, Raven

citations alone should convince

and well in academia.

him

that

Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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May

/

26, 1978

Dear Ms. Lamb,

I have read the responses to the letter of Dr. Kaiser.
In the juxtaposition and editing, I found a few places where the
meaning has been altered and I commend some corrections to your

attention,

which I assume you

will accept.

I have also indicated some questions raised by the
Dr. Claghorn. I believe
is filled with errors and
I do hope that you will check the questions with him. It would
be unfortunate if your journal, afar a useful beginning, were
to give voice to unproven and undocumented allegations, opinions
and experiences. I am sure that Dr. Claghorn knows better, and
a little encouragement will get him to clean up his sections,

letter of

it

I hope.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>June 10, 1964

Mrs. Frnncio C. Lamb
6170 Waterman

St. Louis 12. Minnouri

Dear Mrs. Lamb:

It

in

difficult to tell

who: openings do develop from timc to

tins in our laboratories. I would be gratoful if I could have
a copy of your curriculum vitac. including your educational

experience. a

boon

list

affiliatcd,

of programo or projects with which you have
and any publications which have been developed.

Thank you very much

for your inquiry.
Sinccrely yours,
Kn: Fink. M. D.

Director

HF/jb

�</text>
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                    <text>r—w—
.

.‘mw—wWWWWlW “we"...‘

...v

1mww‘ we .

,

.

1mm.'~v

w-—‘-—mm——qu

.. _is .Vr

w-v—

wriv

-u-v:

C

l

August 17 . 1979

Drs.J.

Lambourn

Harrison Hospital
Dorset, England
Dear Dr. Lambourn,
me a
ECT.

letter is in the nature of a belated thank you for sending
detailed version of your ECT study comparing full ECT with simulated
It is difficult to fault your study, for some of the controls which
This

seemed necessary (and omitted from the BJP article) were included in
your study, notably measurement of seizure duration and evidence of
bilaterality of seizures. Your findings remain inexplicable in the face
of our experience, and perhaps the best explanation may lie in the
question raised by Jan-Otto Ottosson. He notes that not every seizure
is full in the brain, and indeed, in our studies of the EEG effects of
ECT and flurothyl seizures, we did find patients in whom the EEG changes
were astonishingly small compared to others; yet we believed we had
achieved full seizures and had measured their duration. While this
remains a conjecture at this Junction.
may be an explanation,

it

In our study of subconvulsive—convulsive ECT, we used a minimum
of 12 seizures and our data fell compellingly on the side of sonvulsive

therapy being more effective than subconvulsive. The best description is
found in my book which has Just been published by Raven Press.

Your data are puzzling and one would hope that in addition
to your further studies of differenttcurrents on the ECT process, that
the mesurement of the seizure itself may be done to assess whether the
differences in outcome may be related to ancettbeal difference—~ shorter
EEG seizure time, less spiking activity, gtg_as suggested by Ottosson.

regret that I find in the aftermath of your study is
Dr.
Kalinowsky to harangue the psychiatric readership
the opportunity given
with his antipathy to unilateral ECT. I cannot believe that this factor
alone explained the difference in outcome, but perhaps it was a factor.
(Our studies and those of Ulett were with bilateral electrodes.)
The only

These thoughts are inconclusive, as you can tell. I think
your study well done and I congratulate you and Dr. Gill on carrying
out. I can only hope that you will persevere to explain the difference
between your findings and some of the others in the literature.

it

Good

luck in your work.
Sincerely yours,
Max

Fim‘,

MOD.

-

raw

.

w n-rw

"

v

�</text>
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                    <text>“WM.“

WW,

mm.

Gctober 13, 1967

yv‘y-wyw

‘I'w—v—n-g?

..

—'.

Mr. Arthur G. LaMirande

Bruno and
381
New

Stratton

Park Avenue South

York,

New

York

Dear Mr. Laﬁirande

Enclosed ﬁs Figure 5 and the legend for the report
"Digital Computer Anaiysis of the Human EEG in Psychiatric
Research."

n».

yr,

V”,

Thank you

for your patience.

m,

Sincerely yours,

41'

;-.»_uwnr—v»

uu-W.

.-

Fink. M.D.
Professor of Psychiatry

Max
-

”Wm

Mszp

�</text>
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r“ nimvwrw.“

n

-w...

i

.

.

..

.

.

October 12, 1967

Arthur 6. LaMirande
Grune and Stratton
38l Park Avenue South
New York. New York

Mr.

Dear Mr. LaMirande:

Enclosed are the figures for the report "Digital Computer
Analysis of the Human EEG in Psychiatric Research.“ Figure 5
is still at the printers and will be delivered Monday and should
be in your hands by Tuesday.
Thank you

for your patience.
Sincerely yours.
Fink. N.D.
Professor of Psychiatry

Max

iii-”:94:
ENC .

�</text>
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                    <text>.
u

W.~q,..—A~qw~w—v:.ws-.w-

wwﬁr‘h-nmvzl-t

w-

May

l.

1968

Editor

Lancet

Editorial Office
7 Adam Street

Adelphi, London, H.C.2
England

Gentlemen:
The

recent annotations 'Addiction

little

New

Style'

and 'Drug

reference to the use of
narcotic antagonists in the treatment of opiate dependence.
As alternate pharmacological models to methadone, clinical
trials have been undertaken with a long-acting narcotic
antagonist, cyclazocinel‘8 and more recently. naloxone.°‘13
These compounds provide engagement to the treatment program
not based on legal restraint or drug dependence ubiqﬂlgggyidggﬂwnmwm, agent.
an opportunity for habilitation and education so essential to
the addict's integration into the community.
Dependence:

A

Symptom' make

British arrangements for treatment of addicts
emulate
the unsatisfactory American experiences.
to
appears
We would commend these models to your attention for further
study in the new centers.
The new

Sincerely yours,
Fink. M.a.
Professor of Psychiatry

Max

Alfred M. Freedman, M.D.
Professor of Psychiatry and
Chairman of the Department
MF:kp

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                    <text>Soptonbsr 27. 1966

William Landau
Tbs Hoodlsuork Socisty
Dspartssnt of usurology
Withington anivorsity adhool o! nadicins
01in Hall
St. Louis. Missouri
Dr .

mt 3‘11:

plsaso extond my rogrsts toNew York
tbs ﬂoodlmrk Socisty. Sines loving to
not he possibls‘ to attend tbs outings
will
it
and I an hsroby sxtsnding my usignation .
This transition to ﬂow York has boon an
easy ons and tho children ars sxcitsd about:
thsir schooling.
Would you

ﬂy

but

regards.
Sinesrsly yours .
rink. 14.13.
Profuse:- of Psychiatry

ﬂax

�</text>
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                    <text>I

A

_v

A

-\._~_w‘

m»:

May

23, 1963

Dr. William Landau

Damn-3t of Mourning

Washingtm Winnity Servo).
600 S. Kingshighway

,

of Mudicim

,

St. Louis. Hissouri

m Bill:

I swam like to

ram

Dr. Tum 11:11. Principal
Scientist (EEG) in our:~ march cantor, far
in the St. Denis Society of Namlogical
Wmhip
Salmons.
Research

I mtakingthelibartyofencloaingaaopyofhic

aurriculmn vita and hop. yaw mitten 9111 «1:131er
this rumination at its next mating.
’-

Sixmmly yours,
Max

“Fm:

We

Firm,

Inmater

M.

D.

�</text>
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_

. .-

Jamar-”No---w.--;..u.v-umvw.“I'm”'1n3'w14'f‘m‘7l'r‘m-ﬁarm-saws. «mm—"7m.y’rm‘ﬁs-‘W rme‘yun-wnrmum

~.—'

.7 -»—-u«

.

awn w "W" r-l'W'e-V'Iu

U‘vm’ “Jr—1".Yr'wrn-‘J‘W

w-p

n

xswvnuaw-ww.» an

'7

«w

”up-v.

--,~,——~vn-——~m-1-uvwxvu-.—

March 18, 1977

Assemblyman Irwin Landes
New York State
Albany, New York
Dear Irwin,

I am chagrined to learn that you have been in the forefront
in the support of the expenditure of New York State dollars for the
medical school in Israel. No matter that the goal is a good one; or that
Israel. In this time of
as a Jew, I personally support good deeds in New
York dollars to
limited funds in New York, how dare you use
?
in
foreign
country
a
support a venture

action is even more deplorable as a model. What will
Support medical schools in Roma for the Italians, Madrid
for the Spanish speaking, Dublin for the Irish ? And why not ? Are
the Irish, Italians, Polish, negroes etc. not as entitled as the
Jews to special medical attention ?
we do next

wn~av~pwneg~r~wwawumm~w

.
v

~

‘

Your

?

Even worse, we have a medical school at Stony Brook with
only 48 students in a class; with its funds cut this budget year. Why
not storm the Governor's office to increase the funds at SUNY and
force the acdeptance of more students there before you open the

Pandora's box of special legislation for the Jews in Israel?

3

w

u—

»7

m-u

w-n;

..

response
him

for

was
ﬁim

The news reports said that
to veto this special bill.
to change his mind ?

Governor Carey's
What payment was

initial

offered to

v-r'.w'

'_-"v-.~'p-'-

—,

W.-.”

.v—v-

I

distressed.

already have to much emphasis on
quotas and special legislation for minorities. Bilingualism is a
road that we in New York will find rocky in the next few decades.
Now, your special legislation in Wsrael. I am chagrined.
am

We

M

Sincerely yours,

w-w—‘H-“Mvmn

-

Max

.,-

wmzcw-w-r

39

Arleigh

Great Neck,

Road
New

York 11021

Fink,

M.D.

~r,a~.wx—.v—

n. n-vsxr .z-‘ra ,—

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                    <text>November 12, 1970
Mr. Howard Lane
81 Central Park Road

Plainview,

New

York 11803

Dear Mt. Lane:

I

am

I have read your letter with interest,
unable to assist you.

I do not know of a
short of transfusions.

nor

way
We

and

regret that

of increasing red cell cholinesterase,
effects of choline

have not studied the

L—Dopa.

seem of interest and if these are sufficiently
section
advanced, perhaps you have contucted the clinical chemistry
Your

of

studies

NINE.

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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