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                    <text>Septembor 6, 1968

Dr. James Lowry

Director, Dopsrtusnt of Mental
1500 Fifth street
Sscrsnsnto, California 95816

Hygiene

Dear Dr. Lovry,

repott presented at the Hostsrn Institute was
st our study units and presented
in various papers. ooms published sod some in press. The
most recsnt sunosry is that prepared for Dr. Phillipson's
The

a synthesis of dsts collectad
volums on drug dependence.

entitled "Antagonists in the

Treatment of Opiate Dspsndsnce“.

Additional reports are enclosed as background material.
Thank you

rsvidw of the

for your interest

LSD

and for tho excellent
and hallucinogenic problsns in California.

Sincerely yours,

v
«A

,

Pink, M.D.
Professor at Psychiatry

Max

v.
.4

”—2,;-

.v'v’

V'Wv‘ltw‘”.-qw:m"ﬁlw;nvrrvyz'JVa*-'

w

v,»

ml

�</text>
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                    <text>”.1

,‘

”gnaw“.

..m..4

Saptcnber 6, 1968

M»,-

1

(no:

Lamar—r1,

Dear Murray,
Tha menbcrship committee chairman, A1 Frcadnan. has
asked that we supply him with an accurate count of the
membership, no that he can plan for the additional members

to be invited.

that your

-

list

Hy lists are not up to dntc, and I believe
in probably the bent.

-:-w—:.W~a&lt;

-'r‘h'«‘L

mm“:

wnuwv-vwar-w

ﬁbula you ask your sacrotnry to make a count of the
members, less the honorary and other spacial categories,
and lat me know ?
Many

thanks.

u
:r
02/-

UV

A

Sincerely yours.
Max

Fink, Md).

�</text>
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                    <text>September 4, l968
Dr. F. Hoffmeister
Institute of Pharmacology
Farbenfabriken Bayer A.G.

Wuppertal-Elberfeld
West Germany

Dear Dr. Hoffmeister:

During the CINP meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist, whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
We

and I am pleased that we have
clinical supply for studies that

also discussed naloxone

been able to obtain another

are now in progress in the treatment of opiate addiction. Of
course, we are interested in other narcotic antagonists, especially
those with a duration of action longer than naloxone.

trust that you will have
your next trip to New York.
I

on

an opportunity to

visit

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

us

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                    <text>,v

"gr-w

m

np—~

—

m

raw—me

September 4, 1968
Dr. F. Hoffmeister
Institute of Pharmacology

Farbenfabriken Bayer
Huppertal-Elberfeld

A.G.

West Germany

Dear Dr. Hoffmeister:

meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist. whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
During the

CINP

also discussed naloxone and I am pleased that we have
been able to obtain another clinical supply for studies that
are now in progress in the treatment of opiate addiction. Of
course. we are interested in other narcotic antagonists, especially
We

those with a duration of action longer than naloxone.
I

trust that

on your next

you will have an opportunity to
New York.

trip to

visit

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

us

�</text>
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                    <text>September 3, 1968

Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Chicago,
Dear

Illinois

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community - based
operation. Your presentation convinced me and I have written
a memorandum to Al suggesting we examine such a program seriously.

possibility of studies of

acting methadone
to participate in the
To carry out such a
with
we
Paul.
of
discussed
study
type
IND
and eliciting the
of
the
an
project may require
filing
of
manufacturer
the
for
continuing supplies. I
support
would be pleased to help in any way that I can.
The

is impressive

:.—mmnwzrw—V

Good

a long

and I would be pleased

luck in your program.

My

best regards.

rr'

Sincerely yours.

‘mWa

:4”-

1-:

FW‘FJ’V

Max

Fink,

M.D.

'

Professor of Psychiatry

MFtkp

,

‘WCW'V’W‘NWXDH

�</text>
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                    <text>September 3. l968
Dr. Alfred

M.

Freedman, M.D.

Department of Psychiatry

York Medical College
East l02nd Street
New York, New York l0024
New

ma

"hum

W!

n

,

um

'«I'Wg'

";‘~r‘"

‘&lt;._

'v"qvvn&lt;

5

Dear Al,
Thank you for your kind invitation to participate in the
Second Edition of the "Comprehensive Textbook of Psychiatry".
The widespread acceptance of the First Edition assures its

continued success.

It will

be a pleasure to participate again, and I will be
to
provide the section of "computers and psychiatry".
pleased
As you know, I am a protagonist of a more general application
of EEG to psychiatry and perhaps you could consider the inclusion
of some of the recent reviews in either the sections of EEG or
of psychopharmacology.

Sincerely yours,

;
rs

n

Fink, M.D.
Professor of Psychiatry

Max

&lt;165ryﬂ';7llvv

W”

i
.u-rm

Wf‘ﬁ'ﬁs‘.

V

‘

MF:kp

�</text>
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                    <text>September 3, 1968
Dr. William Guy

ECDEU Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,

to thank you for the data analyses of our two
studies. butaperazine and ketimipramine. These have been
most helpful and I believe that these results. as I have
presented them to the staff will assure their greater
cooperation in future projects.
I want

Enclosed are data outputs from our present laboratory
data forms. You will note that there are three types of
output - a reading of the optical scan report; a summary
by patient giving a portrayal in time of each of the
laboratory reports; and a summary for each laboratory test
of all the reports in that study.
The data form used in these analyses did not have room
for the drug, dose or route and these have had to be added
by keypunching. Also, the forms develOped in Missouri have
many items which do not come from the clinical laboratory.
As a result, we have created a new fbrm which corrects many

of these apparent deficits.

If

Copies are enclosed.

such a form could be used, and especially if various
be encouraged to carry out laboratory analyses
could
centers
in patients not receiving novel psychoactive drugs but either
placebo, no drug or accepted FDA approved compounds, then we
can develop a set of laboratory standards both for individual
laboratories and for the ECDEU program as a whole. Such
standards would be most useful in answering the questions
of the FDA and of industry with regard to the significance
of "abnormal” laboratory findings.

�-2-

Dr. Guy

September 3, 1968

I shouid iike to make a report of the 01d iaboratory form,
the data outputs, and the new form avaiiabie to members of ECDEU.
Before doing so, I would like to discuss this with you, Dr. Saizman
and/or Dr. Levine - whichever you recommend.

Again,

my

thanks for your heipfui anaiyses.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

�</text>
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                    <text>.ﬁwnv—nwvw

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WV. "thaw.“

s.7_

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September 3, l968

Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Illinois

Chicago.
Dear

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community ~ based

operation.

Your

a memorandum

The

to

and I have written
suggesting we examine such a program seriously.

presentation convinced

Al

possibility of studies of

is impressive

type of study

me

acting methadone
to participate in the

a long

and I would be pleased

we discussed with Paul. To carry out such a
require the filing of an IND and eliciting the
support of the manufacturer for continuing supplies. I
would be pleased to help in any way that I can.

project

may

Good

luck in your program.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

.

-

w-wn

�</text>
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                    <text>September 3, l968
Dr. Hilliam A. Frosch
New York University Medical Center
550 First Avenue
New York, New York l00l6
Dear Dr. Frosch:
from Professor Votava may have been a bit
premature, for in his enthusiasm, I believe he did not wait
for the forthcoming meeting of the Program Committee of the
GIMP.
I do not know how to answer your request except to
tell you that the CINP holds open meetings every two years.

letter

The

All participants provide for

their

own

expenses with the

occasionallexception of special invited lecturers whose
expenses may be deferred by the Program Committee, if, and
only if funds for such a lectureship are made available by
private donors.

_

The Program Committee will be meeting in the Spring of
l969 in Prague. I plan to attend and as soon as I return
should be possible to answer questions regarding the need
for abstracts, length of paper, egg, Accommodations and other
details of the meeting itself will be sent to members of the
GIMP and to all participants late in 1969.
It is also our
intention to plan a charter flight and details regarding this
will be sent to you at the same time.

it

That

is. if the

the climate in this
My

Russians permit such a meeting, and
country has not changed.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

if

�</text>
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                    <text>September 3, l968
Dr. John A. Scigliano

Executive Secretary

ad hoc Marihuana Advisory Committee
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

Separately, I am answering your letter of August 23,
regarding the additional information requested by the
Advisory Committee which met in July l968. I trust that
these answers will satisfy your interest.
have a list of the present ad hoc Marihuana
Committee?
Advisory
May I

Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ko

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                    <text>September 3 , 1968
Dr. John A. Scigliano

Mecutive Secretary

ad hoe Marimana Advisory Camittee

National Institute of Mental Health
Wisconsin Avenue
Chevy Cruse, Maryland 20203
51450.

Dear Dr. Scigliano:

for your letter of August 23 referring to the
Advisory Cannittee meeting of July, deferring my request for
legal supplies of marijuana and me for research, pending
answers to questions raised by the Committee.
Thank you

The following

are the answers requested.

First , let me imiioate that the BEG-behavioral studies of
any new drug are complex and while some analyses can be accomplished
with few trials, most require many experiments. The number of
trials (and the mnnber of subjects) are "as many as necessary".
For example, the recent analyses of fenﬂmemine required twenty
subjects only. For heroin, however, we have completed mm than
one-hundred and fifty trials in mre than seventy subjects and
methadone we now have mre than eighty
still areinunsatisfied. Forand
probably have enough for a preliminm'y
subjects
twenty
record:
analys 5.
additional problem is the rwte of ministration. We have
limited experience with drugs given by inhalation. I anticipate
that we will make many errors initially. For this reason the answers
to the questions below are approximate.
(I) How many subjects me you planning to use?
An

,

sw/W-znanz'nm'rz

Wﬂm.-lﬂﬁ"5‘7AY¢3meﬂNm79'r-T\VNY'

run:

mains-1

raw

:‘Wx‘v

(a)

POM-addicts?

(b)

Momma?

(a)

20—30,

(b)

6

-

12

fewer,

How
How

’

if

repeated

many?
many?

trials are satisfactory.

�-2-

Dr. Scigliano

(2)

September 3, 1968

Dosage
(a) Dosage to each?
(b) How my doses?

(a) Dosage to each?
1. Tm: 20 mg initially. This dose will
be increased as needed until either EEG
or behavioral effects , or both are
clearly manifest.
2.

(b)

How many

1.

2.
(3)
g
s
E

Marijuana:

'IWo

"puffs" increasing to a

full cigarette or nultiple cigarettes ,
as wmnted.

doses?

at least two trials per subject,
If the dose response
becomes of interest , probably three to
five doses for each subjects.

THC:
THC

Same

and a blank.

as

THC.

subjects to be scanned psyche/tummy
(a) Post addicts: a psychiatric examination is recozded
in each subject. Those with complicating diagnoses ,

How

Me

«the

as depressive psychosis , schizophrenia or chronic
alcoholism are excluded.

E

E
E

E

Q

(b)

E

Volunteers: Each volunteer undergoes a psychiatric
examination and evidence of psychosis is sufficient

reason for exclusion. In addition, we plan to
include only those volunteers who admit to previous
marijuana exposure in these studies. Each volunteer
also completes the MW]: which we are not investmating
as a screening device.
(4)

whet

mama will be taken to pleated: the normal vomnxeu?
present study progmm with normal volunteers provides
the basis for the trials with marijuana and THC. The
project is frankly eXplained to each suhﬁect by a
research assistant and then again at the end of the
psychiatric interview, by one of the senior scientists.
At the end of this explanation the subject is asked to
sign a permit for a research study.
The

�-3-

Dr. Scigliam

Septenber 3, 1968

After each exposure, subjects are advised
to undertake only limited activities for a
minimnn 2n hour period. We do not permit

thentodriveaoarardpayalltaxiexpenses
home
member
and all subjects
is monitored by a staff
areaskedtoretumtothe 2Hlaboratoryortobe

to and from the laboratory. Their return
visited by a staff umber

hours

after exposure.

In the event of an untoward reaction, admission

to the Psychophamacology Research

Metropolitan Hospital

Ward

of

is assured, or for

females

the private pavilion of Flower and Fifth Avenue
Hospitals is available. The principal investigator

is

m

W'v-

-.

(5)

(Um-v

psychiatrist at both institutions.
CW” 5M. the heaoin challenge studied - the due
and whethu M4119 poet-addicts and/on newt voluntew.
Heroin challenges have only been done, so far, in
post-addicts. Our usual dose is 15 - 30 mg/ch
saline/ 2 minutes intravermsly. When heroin is

Yty'rI-‘Q'Wﬂmrr’vn'x

given to subjects who are not receiving duonic
narcotic antﬁonists , we administer intravenous
naloxone (1 mg) at the end of the eaqaeriment and
give oral naloxone (2 mg) approximately 3 hours
after heroin exposure.

F,¢n-.¢u~v.—

Man-w,

..

.—

n

sea-.1

V’a-zr'"

Viva“

:v

xy-nvawvv

an attemling

(6)

a
$221be
heat £a

ace

«:0qu be

~

the dwge - both mau’juana and A9-THC
ue compounds and the passe/med Manage
l8'CC. Secwxg Ahoutd be mntained by

inch and hey.

.r:

:

&lt;t1wemvvrwmr¢smmmrmwwrr

wa'rv

,

'er-r‘

W‘s,-

Stability of the drugs: yes .

�a.

Dr. Scigliano

(7)

September 3, 1968

-l&amp;-

0554mm! owe/L 5mm: -

etc.

Letter requested (see xerox enclosed)

Sinceme yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>September 3 , 1968
Mr. Edward

J. Fitzgerald, Jr.

120 Chm-ch

Street

District Director of Internal

New

York,

New

Revenue

York

Dear Mr. Fitzgerald:

are anxious to undertake studies of mrijuma and have
previously filed for a narijuana tax receipt. We have received
this and a copy is enclosed.
We

In attempting to follow existing regulations, we have filed
the National Institute of Mental Health BREW, the necessary
application forms for marijuana and TH). The Executive Secretary
of the ad hoc Marijuana Advisory Conmittee, Dr. John A. Scigliano
has mitten to us on August 23 requesting that we obtain an official
order form. A xerox copy of his request to us is also enclosed.
With

Followm his request,

letter which comments

would you kindly

our licensing in Class

furnish us with a
V

for marijuana?

In the event that this letter is addressed to the wrong
authority, wcmld you be so kind as to call me directly at
(212) 369-7900 Ext. 2% and advise me as to the proper office
to which this request should be directed.
Thank you

for your cooperation.
Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

MF:]-:p

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                    <text>September 3 , 1968

Jiri waicek
Prague 8 - Bchnice

Dr.

Psychiatric Research Institute
Czechoslovakia

Dear Dr. Roubicek:

return from holidays , I found your kind letter of
the reprints describing your origiml studies of
convulsive therapy. Two reports in particular are most interesting the studies of the pathway of electrical current and the EEG changes.

July

On my

30 and

We

are comparing the clinical

and EG

effects of unilateral

bilateral convulsive therapy. That the memory
in these two treatments is well knovm, with bilateral
differ
patterns
ECT inducing, nore memory changes than unilateral. But the EEG patterns
are poorly described. We find the sauna changes with bilateral reported
by yourself and many others - high voltage delta and theta activity ,
bilaterally. With convulsions induced by a unilateral placement of
convulsive with

chzmges are much less pruninant with a decrease in
and asymmetry as the most cannon.
synchronization
voltages , poor
The bilateral slow waves of grand mal ECT are missing. Perhaps you
can recall from your old experiments an answer to the question of

electrodes , the

what the differences in pathways would be for seizures induced

unilateral placenent of electrodes ,

when compared

iter

to seizures induced

after bilateral placenent?
I could only read the Ehglish smmry of your study of

EEG

and

electroshock? That you did not find the same as Roth (or ourselves)
is unfortunate and may probably be a function of the time or the
techniques of III-)3 analysis.

have been much troubled by the stories in our newspapers
new in progress in Prague. I hope that these do
not interfere with your plans. You know that we will do whatever
we can to assist you, or other members of the psychophannacolcgy
society in continuing your studies under the Host optimal conditions.
We

of the changes

�-2-

Dr. Roubicek

September 3, 1968

It may be of some help to know that Professor Turan Itil, a close
associate in our research programs will be attending the forthcoming
WHO Meeting in Yugoslavia.
I am sure that you or your associates
can discuss with him your programs of research.
Thank you

for your reprints.

Incidentally,

and Dr. Matousek.

of the work of Dr.
itamwas good to hear have
had

I

glad that they

Volavka

an opportunity to
visit the many laboratories in Europe and hope that we can hear
more of what is in progress when next we meet.
My

best regards to you, your family and your fine associates.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Septanber
Dr. 0. Vinar and
Dr. Z. Votava
Psychiatric Research
Prague 8 - Bohnice
Czechoslovakia

3

, 1968

Institute

Dear Drs. Viner and Votava:
Thank you for your kind invitation to participate as a
number of the Program Cazmittee for the 1970 CINP Congress in
Prague. I am pleased to accept and look forward to joining
you next spring.

dates suggested, Amil 11-12 , are diffiwlt for me.
require a special trip. However, I plan to be in
It
Europe fmn May 11-16 and would find it convenient to meet
with you either on May 8-10 or early in the week of May 18.
Either of these dates would permit me to make one trip.
The
would

If these dates are not convenient , it may yet be possible
tobeinﬁuopeleteinf‘ebmaryandlmuldbeableto joina

meeting in Prague
and March 2.

at the

end

of that

month , between February 28

I hope it may yet be possible to arrange the meetings of
the Program Oomnittee at any of these , more convenient dates .
I

to suggestions for topics of synposia of the Congzees ,
listing these sepamately in the attached menorandmn.

As
am

I look forward to joining you in the spring.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

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                    <text>“my

...

September 3 , 1968
Dr. Milos Vojtechovsky
Institute of Pharmacology
Medical Faculty of Hygiene

Charles University
Pram 10 - Vinohrady, Srobarova

Czechoslovakia

50

Dear Miles ,

I have received a kind invitation from Dre. Vinar and
Votava to participate in the Program Conunittee for the 1970
meeting of the CINP in Prague. As I answered their invitation,
I was reminded of my lecture at Charles University and the many
kindnesses of the members of the Czechoslovak Psydmphammcology
Group.

I

found the discussions dwing that visit most valuable
and, as our study programs are eXpanding, we would be pleased

to

available to

you or qualified Heathers of your society
continue
Opportunities to
our discussions and participate in
om." study programs.
make

Professor Turan Itil, a close associate and a member of
the faculty of the University of Missouri , will be attending
the WHO Meeting in Yugoslavia early in October. I ism that
he would be pleased to discuss our programs with you, if the
oppm'tunity presents itself.

I have just

had the opportunity

to read Simhies little

volume "Biological Psychiatry" and was most interested to see
that he gives credit to you for many of the discussions in this
fine volmne.
My

best personal regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Septanber 3 , 1968
Dr. Jean Titeca
University of Liege

Psychiatric Clinic

11, rue de la Luzerne
Brussels 3 , Belgium
Dear Dr. Titeca:

It will be

Dongier and
a pleasure to join Professor
EEG"
at the forthcoming
yourself in the section on "Clinical
symposium on the nem'oleptiques in Liege on May ISL-16 .

I look forward to discussm the EEG changes with neuro—
leptiques and other psychoactive canpcunds , both in patients
and in normal volunteers. For the past few years we have
measured

emphasized the wide range of changes which can be
using the latest digital computer methods of EEG analysis.
This data has recently been useful in classifying the
Spectrum of psychoactive compounds and a discussion, either

of the varieties of EEG patterns that allow for the classifica~
of the
tion of psychoactive canpauﬂs or a detailed discussion
be
possible.
nemephysiology of the neuroleptics would both

for the expenses of travel , it is most difficult to
answer at this time. You may know that the principal sauce
Health
of travel funds are the research grants from the Public
March
of
Service or special funds of the university. Since
from
the
this year, foreign travel funds have been unavailable
As

Public Health Service accept under very special circumstances .
funds are
a consequence of govermtental cutbacks , university
from both
funds
also severely restricted. While I will request
make
our participation
sources in the hope that either one will
will not be
answer
the
symposium
possible,
in this important
ask that
available until next spring. For this reason, I would
made
available
the organizing caunittee inquire if funds can be

As

from Europe.

�~2-

Dr. Titeca

September 3, 1968

Separately, I am pleased to send you a copy of a review
of the nemphysiology of psychoactive compounds which I have
just completed for the 1969 volmne of the Amual Review of

Pharmacology. This should provide you and Professor Dongier
with sufficient information about recent work so that our
participation can be placed in ﬁe best context.

thanks for your kindness in considering our
in
participation this interesting symposiwn.
Again,

my

Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>September 3, 1968
Dr. ?radar1ck Clark, M.D.

ACE.

Rabm.

Richmond, Va.

‘30.

Dear Dr. Clark,
Thank you for tha informational material to: A£R~1900 and thn
enquiry regarding an EEG study of a dalayeé aetiou funﬂlurcmine.
I hava found both queantons of grape intarest and cansiderahle
challenga. and would lit: the opportunity to discuss this with
my associate:. Unfortunatsly, two are still away on holidays
and will not return for another week, and I will be away for
aama dsyn

thereafter.

I am writing to ask yaur indulgnnce 13 my daisy
in annuaring these enquiries. I will writs or nail yan ﬁuring
the third waek a! Septanbar.
Sincerely yours,

Fink, M.D.
Prefeanor of Psyahiatry

Max

'm/

�</text>
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                    <text>September 1, 1968
Dr. Francis Chinnrd
Professor and Chairman

Department of Medicine
New Jersey College of Medicine
East Orange, New Jersey‘
Dear Dr. Chinerd,
Thank you for your kind invitation. or the history
which
to
you refer, I know only that which has appeared in the
I
public press, and as I had no personal involvement with
paid little direct attention and as a consequence, know little

it,

of the

institution's history.

opportunities at the New York Medical
College are
satisfactory, and I have given no thought to
another move. Nevertheless, I would be less than candid if I said
that a leadership role in a medical center did not interest me.
The programs and

most

I am enclosing a copy of my curriculum vitae and
bibliography for your consideration.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>December- 30, 1968

Dr. William Tabor

A. H. Robins Ounpany
11407 Clmmings Drive

Fidmnnd, Virginia 23220
Dear

Bill,

RE:

Butapemzim. Syrup S’mdy

There are two patients who are receiving butapemzine
syrup and who should continue this form of treatment since
they have done well and Dr. Clare would prefer maintaining

the medication to allow mintenaxwe of the present state .
Smuaries of the two cases are attached.

An investigation of our supplies of 12/ 27 indicates that
we have 9 pints placebo and 70 pints butaperazine available .
Would you please file an mandaent to the study protocol
allow
us to continue these two patients for a minim of
to

one year. As soon as we have found other ways of treating
them we will return the renaining supplies of butaperazine.
Thank you

for your cooperation.
Sincerely yours ,
Max

Fink, Md).

Professor of Psychiatry
MF:kp

�</text>
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                    <text>monomer

30

, 1988

Ir.

Jean Titeca
University of Liege

Psyddatric Clinic

11, we do 1a Luzeme

Bmsela

3,

Belgium

Boar Dr. ‘l‘iteoa:

to moeivo the invitation of Professor Bobon
8.1.1?! . in Liege in May. As you 3mm, I
the
in
to participate
the
goal of relating EEG ﬂanges to
have actively wood

I

was pleased

ounpomwds since 1955 . Tm
was held
Hanan
and
Psycmphamyaoology
on
first symposiumWorld
members
Four
of
of
Fsydiiatry.
1961
(ingress
in
at the
S.I.1‘-i.
may
arﬂ'it
the
of
invited
tho
list
on
that pawl
be useful to bring this mmkable subject: note—date by presenting
the data of the past seven years. In that regard, I am ornloeing

behavioral (effects of psydioactive
EEG

m

as mquested by the Secretary of a presentation for the
a
The
data is atomized in sufficiently succinct form to
3.1.N.
provide the basis for a theory to be discussed. The theory of
interaction of brain fmction and behavior is rooted in other
biological momma , notably EC? and ICI‘ , but has its; best
expmssion in psychoactive dmgo , and especially in antipoyohotio
drugs.
technical features of the
In addition, them are

sum

latest analytic

of the S.I.N.

methods

m be of interest to

that

the:

may

participants

I look forward to participating in your sassions in
Sincerely yours ,
Max Firm,”
,
.

_..

M‘mp

,
«.1

.

Professor of Psyohiatx'

,
A)

"Wynn”;

rm).

cc: Dr. Bomn

May.

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Vs

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102ND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYCHIATRY

December 28, 1968
Dear Jack,
~~Thank you for your letter and I am enclosing some
articles which may be of interest and some comments. First, however,

about EEG-— I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study

shows an equivalence for period analytic and power spectral methods—and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either easily and do use whichever

lends

itself to the

analysis. For
spectrum.

a

problem at hand. For simple drug changes, period
detailed analysis of the faster frequencies, power

This is a very difficult question for me
review of our data, and the report which
indicates that even (or especially) in shronic mentally ill we ran
a significant risk of inducing psychotic episodes; I am also
aware that in this group spontaneous psychotic episodes occur fre—
quently. Our article is enclosed, as is a review from the Canadian
Mediéhal.Association Journal. This latter is the most complete to
As

for

LSD.

to answer. Despite

my

date.

position is to tell young people that experimentation
is'always exciting and frequently useful; but also occasionally dan—
My own

gerous. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., a laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk is the fact that the supplies on
the street are often impure and adulterated. I tell them about the
heroin supplies which we get from the FBN and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and scopolamine;
and of the LSD that was scopolamine (each analysis in our laboratories).
The most difficult problem is the question of marijuana, which is
more like alcohol and less like LSD; is probably safe even in large
doses; is non—addicting in the usual sense, and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,

�-2and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—— hermits and other isolation
devices; drugs and other temporary mind—clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been also useful.
In answering such questions (and I have frequently) I am
not embarrassesLby the question of 'Why do you
, and tell us
that it is bad for us?'/since I have tried all the drugs and do not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.
How

LSD

2

useful these approaches are will not

be known. The

kick has stopped iﬁ'New York and the incidence of admissions to

hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The evgidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of--and tell them of
the interesting studies of thalidomide and pregnancy.

sufficient for the present. In View of
am
I
the possible additional help,
enclosing a pre-print of a study
of hallucinogens that I completed last year for the ACNP and which
‘will be in press in the spring. This describes the central effects
of two large classes of hallucinogens in man and has been useful in
These ideas should be

documenting

my

'credentials'.

pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was recéved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin IV); but that we are continuing the
I

am

studies nevertheless.
My

'

best regards.
Sincere

Max

y

Fink,

yours,
M.D.

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                    <text>-..

..~

m.

l...

g, i; rm
\k.

min

.M;

{C 0

December 28, 1968
Dear Jack,
Thank you for your letter and I am enclosing some
which may be of interest and some comments. First, however,
about EEG~~ I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study
shows an equivalence for period analytic and power spectral methods-and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either eaeily and do use whichever

articles

lends

itself to the

analysis. For
spectrum.

A8

n

for

problem at bend. For simple drug changes, period
detailed analysis of the faster frequencies, power
LSD.

to answer. Despite

my

This is a very difficult question for me
review of our data, and the report which

indicates that even (or especially) in chronic mentally ill we ran
risk of inducing psychotic episodee; I am also

a significant
aware that in

this group spontaneous psychotic episodes occur fre~
article is enclosed, as in a review from the Canadian
Mediecel Association Journal. This latter is the most complete to
quently.

Our

date.

position is to

tell

young people that experimentation
useful; but also occasionally den~
geroue. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., n laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk in the fact that the supplies on
the street are often impure and ndultercted. I tell them about the
heroin supplies which we get free the FEE and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and ecopolemine;
add of the LSD that was ecopolemine (each analysis in ourbleboratoriee).
my own

is always exciting

and frequently

The most difficult problem
more like alcohol and less

is the question of marijuana,

like

which

is

in probably safe even in large
doses; in non-addicting in the usual sense. and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,
LSD;

�-3and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—~ hermits and other isolation
devices; drugs and other temporary mind-clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been

also useful.

In answering such questions (and I have frequently) I am
: and tell us
not embarrasses by the question of 'Why do you
that it is bad for us?’ since I have tried all the drugs and dd not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.

How useful these approaches are will not be known. The
kick has stopped in New York and the incidence of admissions to
hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The eveidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of—~and tell them of
the interesting studies of thalidomide and pregnancy.

LSD

These ideas should be sufficient for the present. In view of
the possible additional help, I am enclosing a nre~print of a study
of hallucinogens that I completed last year for the ACNP and which
will be in press in the spring. This describes the central effects
of two large llasses of hallucinogens in man and has been useful in

docuﬁenting

my

'credentials'.

I am pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was receved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin TV); but that we are continuing the
studies nevertheless.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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              <elementText elementTextId="35962">
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                  <elementText elementTextId="102710">
                    <text>December 28, 1968
Dear Reg.
1

an,plaased that 133 will canparate with ch¢ Intatnatianal
am writing to suggest some specific details that
the daaonatratians mare mental.

Congress, and I

would make

1. Tha programs

the exhibteiun.

will raquire

a fsw days of dabugging befara

for the éamonscratton shgald be available
a: least one «ugh bafora the axhibitsan, anﬁ beak the axhihitien hall
managers. the shipgors anﬁ 13% abould bu aakaﬂ co agrxe tﬁat the
exhibiclaa actually will be for the period Septamber 6/7 to 20.
2.

Va

The spngm

will plan to damoncttacc

from cages or from a

liva subject.

aha kinds

cf analyaas

um

dc,

For tapas, we will require a 1/2 inch SPBOO Ampux FM
recorder. To damnnatrate the plat pregrama, we use a Tektranix
osailloseope with a long pcxnistancc scruen cad a Palarmid camara.

is

EEG,

In damonstrate that what

parhapa an

EEG

19 caning ﬁrom the tap&amp;
channel from Grams wanlé ha uneﬂul.

for a liva demcnatration. thure will have ta bu
an EEG (Wt pretax Grass) and a band»pass filtar, and a chhhait
would be moat usafal. we vauld like ta show the dfﬁacts of
pentothal and this will allaw us to ﬁamonatrata our mathematical
model at the pantothal response. It may bu less useful in vnlunteers

than a demonstration of a hallucinogtn or a dimpla alarttng experiment.
but wn will tailor tha axperimcntal details to tha setting anﬁ the
ether axperimenta 1n the program.
My

best regarﬁs.
Sincarely yours.
Fink, M.D.
Profnsaor af Psychiatry

Max

�</text>
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  <item itemId="3598" public="1" featured="0">
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        <src>http://exhibits.library.stonybrook.edu/mfp/files/original/df885aef515d5c565c0a5ccc7b0fd08a.pdf</src>
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                  <elementText elementTextId="102711">
                    <text>Dccember 28, 1968
Dr. E.

J.

031119

Arsenal, Toulon. France
Dear Dr. 081113,

I an pleased to accept your kind invitation to participate
in the summer course on 'Automatic Processing of Electtobiological
Data‘ in Toulan betwoau June 16 and 27, 1969. I ptafer June 23 to 28
an that will allaw me to bring mambars of my family to Europe for

holidays as well.
Our

L'JWKW-W'vv-ﬂ-WWWW

develeping methods
to mascara the offsets of paychoactive drugs on the human scalp EEG in
the alert subject. The methads used are period analysis, pave: apactral
denaity, amplitude intagraticn and variability measures. we would
find it not: useful, in View of the astaemad participants and chair
uxtansive axperianue, t0 present an extenﬁed report of various studies,
under the title:

ﬂigitaz

1
,.

Ahmynm.

y-v.‘

pp.”

«$755

,,_

w-npg-z'xwy-H

u
H”

,

"rl'w'v'v'ﬂr’r-v.

"pt-r

7—9»

laberatoriea have been inatrumantal

1n

Computed Analgai¢ 05 UAug Speciéia Signaiuaeb
Making Human EEG.

in the

canauthor for this precannation will be Dr. Donald M. Shapiro, 0.82..
the Director of tha Division of Bicmnndical infatuation Proceusing of
the New York medical College.

My

Less than a full opportunity ta prescnt out data and
extcnoiva augerience will not justify our undartaking such an
axpcnstvo trip, and I would uncourage the commitcen to give conntld
station to this suggestion.

Incidtntally, I have not receivad the cauwunication of
June 18, 1968, and if this contains additiantl information, it may
be useful for you to sené us a cogy.
enclouad.

The

application

forms

for both Dr. Shapiro

and mysalf are

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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              <elementText elementTextId="35978">
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              <elementText elementTextId="35982">
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              <elementText elementTextId="35983">
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  <item itemId="3599" public="1" featured="0">
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                  <elementText elementTextId="105711">
                    <text>December 27, 1968
Dr.

hiiiiam Tabor

1407 Cummings

Richmond, Va. 23220

Biii.

Dear

Enclosed are the corrected butnperazine report forms.
principal difficuity iies in our interpretation of the item 15
and in the inch of discrimination among psychiatric diagnoses.

The

interpreted the item is as

a sampling of the
dosage periods.
occasionniiy
the maintenance dosage; more usually. the maintenance dosage was
somewhat less. The report shows the iargest period of sustained drug
effect. On each, however, we have indicated the maximum dose as
We

had

The maximum dosage achieved was oniy

we

.

Aiso. the date stopped was interpreted as the date of the
report period. In some instances. patients continued
report period. This was occasionaiiy noted on the summary
(narrative) which was written after the summary (report form) was

end of the
beyond the

compieted.

ﬁiagnoses are

all variations of schizophrenia. In some
domponent was given credit in the natretive

instances. the depressive

summary. although chronic schizophrenia was the principai diagnosis.
The use of catatonic, paranoid or simpie subtypes wateadditivo; and

chronic schizophrenia is the principei diagnosis.

trust these corrections cierify the questions.
for bringing these discrepancies to our attention.
I

Thank you

Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

of]

�</text>
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                    <text>December 27, 1968

Dr. E.S. Paykel
Yale University School of Medicine
New

Haven. Connecticut

Dear Dr. Paykel,

I have recently read the report 'Trial of Imipramine
Patients' with considerable interest.
In re«read1ng the retort, I eannot find the data of the clinical response
of the subjects, 1.e., t*teets for the poat~pae drug conditions
for the behavieral measures. Table III indicatea that the differences
between drugs were not aignifiaant-~ but did the drugs affect the
clinical symptoms in the dosages given?
and Chlorpromazina 1n Depressed

appeared elsewhere, and if so, I
the tables. It may be that tha
the drugs or the sub—groups may
clinical change. partially related
to the dosages of chlorpromazine and imipramine selected; dosages
which you indicate are much lower than our own.

this ﬁata has
grateful far a copy of
lack of differentiation between
have haen the result of limitad

would be

Perhaps

It was a pleasure to read the report, and I look ﬁctward
to hearing of equally interesting studies from New ﬁaven.
Sincerely yours.
Fink, M.D.
Professor of ?sychiatry

Max

mil

�</text>
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                    <text>December 27, 1968

Prof.

C.

J.

Miran

Department of Biological Chemistry
University of Athons School of Medicine

Athens (609) Greece

Dear Professor Mirna.

It has been none months since we last wrote and in this
have boon fortunate to obtain a supply of marijuana and of
THC from the National Inotitute of Mental Health. Supplies of both
are severely restricted and it may yet be necessary to ondortako
work in your laboratory.
timo

we

have begun the first trials and havo observed definite
which
effects
are more prominontnnt dosages of 20 mg THC than
15
and
10
5,
are even greater for smoking marijuana. V! have
mg;
or
nodo up cigarettes o£09.5 Gm nook. containing less than 11 THC.
The smoking of one cigarette yioldo EEG effects, but 2 cigarettes are
very definite. 'Theso trials are very preliminary, however, and
will be soon weeks before we are sure of the data.
We

EEG

it

I on planned to tell you that Dr. Martin Xeeler of Durham,
North Carolina, who has written about tho toxicity of marijuana. is
joining my staff in July. We plan to ostablish a marijuana resoarch
project before then, and will try to use the fooilitioa of the
International Association for Payohiatric Roscarch to sponsor the
collaborative aspects in

an

application to

RIMH.

in April and again in May. As soon
as my schedule is crystallized, I will write an&amp; plan to visit your
laboratory. Boforo than, I hope to send you an outline of a proposod
project as the basis for our discussions.
I will be in

Many

Europe

thanks for your Christmas card~~

my

associates

and I

appreciated the special opportunity to one the lush marijuana
growing in your back—yard. Profossor Freedman and Dr. Simeon
join in sending our boat wiahos for a successful and prosperous

New

Year.

Sincerely yours,
Max

Fink, Md).

�</text>
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                    <text>Dacember' 26 , 1968

Library,
of Medicine
103m Street

Academy
New

York,

N .Y.

Gentlemen:
me.

If

Ir.

Rhea Dorhbush

she finds

journals, I

would

is

working on a project for

books and
it necessary to take outher
do

appreciate your letting

so.

Sincere1y ,

Max

Fink , M.D.

Professor of Psychiatry

�</text>
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                    <text>December 26, I968
Dr. Stanley Feldsfeln
255 Wes? abfh

New

York,

New

Sfreef

York |0024

Dear Dr. FeldsTein:
The Infernaflonal Assoclafion for Psychlafrlc Research
ls pleased To have you as a momber of its research sfaff
a? an annuai salary of $3,500.00.

look forward +0 having you participafe In our sfudy
pregrams bofh a+ 102nd Sfreef and af Gracie Square Hospital.
I

Sincerely yours,
Fink, M.D.
Executive Direcfor

Max

MF:kp

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102714">
                    <text>December 25, 1968
Mr. John Balah

Science
Washington, 0.0.
Dear Mr. Halah,

I hsvn read your rcport, "Eutectic: and Drug Abuse: Tao
Fadcral Raapanse" with much incarnat; capaciglly an it accompanicd
a report an marijuana rcacarch by a nedicnl atudunt. The taper:
nugauats that yea urn preparing a taper: an HIKE resaarch in mgrijuana.
I am writing to suggest that if yau wish additionnl data regarding the
impaet of Federal tttitudas on tcucareh in substance abuse, apacifically
raseatch in marijuana. yen may with to arrange to discuss our expartcncea
during the-past fuw years.
Our cantor has bean active in resourch 1n Opiatt addiction. and
ch: stuff consists of aeteatists with many years cxpcrtauce in clinical
and exparimental phnrmacelogy. Despitn adaquata cradentialn at ware unable
to obtain legal auppliaa of marijuana frau May. 1967 until Rabamber,
1968-~ and only obtained son: unpplies from MINE «ban a photagraphor,
making n film on roseareh in narijuan for RINK, csllad to clear the

aupplica so that his film could be unﬁt.

Concurrent with this limitation, vs art now inhibitad from
raauonable cesaarch stadium of unthadone by local nuthoritias. not
because tha study in dangaroun (sine: um are doing the can: study with
more active and less well studics drugs) but beeausa uh: aura of
addiccian parvadas the scientists judgmanta.
-«-;..

‘
.

.,~

m.

'1'“

,

apparent that Fadaral authorities hava arrogatod
which thcy are unable to handle, to the eventual
dutrimcnt of carious clinical research. Perhaps your raview may
reflect song of the axperiences which have marknd the past few
years in this nignificant area of raseardh.

It is

rcsponnibilitica

w

Sincerely yours,

‘r~

muuuv

M

-v-

Ha: Fink, M.D.

I
gr

Professor of Paychiatry

u-w-r—t

Irvx'var-a'v“?saw-”gnaw”

"mg-angs

ml

�</text>
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              <elementText elementTextId="36042">
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                    <text>Dceembar 25, 1968
Dr. D. 81v: Sanka:

Creednoor Stung ﬁanpital

Queons Villnga, ﬂew York
Dear Dr. Sankax.

It was kind a: you an invite me to partieipatu in the
recent symposium. and I found the sannian I ataanded most interesting
and rewnréing. You any rocall that I tank the liberty of turning over
my time to Professor 51:1 Roubicak aha had racantly arrived to join
my staff from Prague. I balieve he has submittad his discussion.
with which I concur.
own. and

It was my imprusnien that his summary substitutnd for
I trust that this meets with your approval.

bust wishes an the success of the valune, and
and
happy ﬂew Yaar.
prosperous
My

my

for a

Sincerely yours.

as: Fink,

M.D.

Professor cf Psychiatry
mil

�</text>
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              <elementText elementTextId="36052">
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              <elementText elementTextId="36053">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102716">
                    <text>Decaabar 25, 1968
Mr. John Walsh

Scianea
Haahinxton, 0.0.
Daar Hr. Walsh.

hava :aad your raport, "Eaxeotica and Drug Ahuaa: Tﬂa
accaapaniad
Padaral Raaponaa" with math intaraat; aapaeially aa it Tha
atudant.
report
nadical
by
a
raaaatch
a report on marijuana
HIKE
in marijuana.
raaaarch
an
a
raport
praparing
auggaata that you ara
the
data
ragarding
additional
wish
that
you
if
I an writing to auggaat
impact of Fadaral attitndaa on raaaareh in substance abuaa. apacifically
raaoarch in marijuana, you may with to arrange to diacuaa our axyariaucaa
1

”7-."

mun-cw

"—7

-

during the past faw yaara.

cantor haa been active in raaaarch in opiata addiction, and
tha staff coaliata of aciantiats with many yaara axparianta in clinical
and experimantal pharmacology. Deapita adequata credentials an uara unable
until Rohanbar,
to obtain lagal suppliaa of marijuana from May. 1967
whan
from
ulna
a photograpbar,
l968~~ and only obtainad aoaa auppliaa
to clear the
callad
RINK,
for
waking a film on raaaatch in aarijuan
be
aada.
could
auppliaaﬁao that his film
Our

Concurrent with thia liaitatiou. wa ara new inhibited iron
reasonabla aaaaatth studiaa of nathadona by local authoritiaa. notwith
bacauaa the atndy in dangeroua (aiuca we at. doing tha aaaa atndy
mora aetiva and laaa wall atudiaa drugs) but haeanaa tha aura at
addiction parvadaa the aciantiata judxnanta.

apparant that Vadaral authoritiao hava arrogatad
the avantual
raaponaibilitiaa which thay are unabla to handla, to raviow
may
Perhaps
your
datrinant of aarioua clinical research.
few
aarkad
tbs
hava
which
past
raflact aona of the axpariancaa
years in this significant araa of raaaatch.
Sincerely yours,

It is

Ma‘

Fink.

MOD.

Protease: of Paychiatry

“3/

�</text>
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                    <text>‘Nr-‘Mﬁm‘~lv‘-

-mgwywwvr~ WV".

. 7-»..‘7, w—m

nu-vu

w

~

1

w

,.

'm wv-va‘JvF—m

Docgdbar 25, 1968

Dr. Vinccnt Dole nné Katie Ryswnndar

nockatellcr University

New

York 10021

Dan: Vine. and Marta,

I have read tha report in the J.A.K.A. and the progrcia
mathndonc program and wish ca aongrntulatc both of
of
the
taper:
n
for
htroic
jab v.11 donc. Although I can. into the narcotic
you
trcstnnnt warld quit. raccncly, I havn axperiencoé many of tha
ﬁéldﬂilttlti?‘, palitical and idaological ntupidititc that aunt

ctforta; and to haw: bccn so succetaful, dcspttc
than: hurdlot. in inanad an achievamnnt. Congratulations !'

have nurknd yaur

Our awn studios luppatt your taper: fully, and I
haw. already cxprtnsad the aplnion that the principal battla has
beta won and that repair opurationn are new neadad. H. at.
prcpnring a au-nnry of our vacant comparison of cyclazoeina and
Inthadanu and this will b: oubataatially supyortiva. Also,
in our EEG studicu of heroin ahallnngoa, the duration 0f mathadonn
untsgouilu is longer than we had antietpntad 3nd 1t: potency incrca-n:

with zinc.

Hy

congrgtulaciona on a job wall done.
Sineoruly yourc.
Fink, 3.9.
Praia-nor of Psychiatry

Mn:

�</text>
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              <elementText elementTextId="36072">
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                    <text>«

4».

q
.1-

w-‘n-vu—rn

u

December 24, 1968
Dr. R. Reich Canaan

National Rnsoarch Council

inshington,

D.C.

Dear Dr. Canaan.

Previously, Dr. yraedmnn has submitted the titles of three
prosentotiona for tho 1969 matting: of the NRG~RAB Committoa on
Problem: of Drug Dependence. In roviawing the data of our comparative
study of cyclazooino and methadone in the craatmant of oyiato dopandcnce,
we helluva that the present uxporianeas will be of more relevance
to the prosont issues in drug dapondance than sons of other
reports. and I am writing to euggoat your consideration of tho

report,

Typologieal Approach to the Tﬁernpy of Opiate

Dependence by Cyclazocine and methadone
Richard Rosnick, M.D., Max Fink, M.B. and Alfred
M.

Fteeémnn, M.D.

Conaidering the negative nature of tho rcpotc, "Tybauata in the
Treatment of Opiate Dependence". we would auggaac withdrawal of

this presentation, if the
Thank you

program

is already congleted.

for your consiéeration.
sincerely yours,
Pink, M.D.
Professor of Paychiatry

Max
MF/

�</text>
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                    <text>December 24. 1968

'

Mr. Herman Heisman
Hoffmnnn La Roche Inc.

Nutley,

Raw

Jersay

Dear Mr. Waiamnn.
we

have received

Va

art

chm

galluy proofs a! the

articla

on

high dose Libriun from ch. Thnrnpnutic Ransarch Press and are
rcturning than with a few corractiona. Thu atrial. will appear
in the January issue of Curran: Thnrapauttc Resenrch.
Granting the minimum quantity of reprints (1000)

will arranga to ship the majority to you, if you wish. If.
in addition, you wish othct reprintu, plans. call my ofﬂico 3nd I
will amend the raquast.
and

my

Again. my thanks for your cocpcrttion and interalt:
best wishes for a prosparous and happy ﬂaw Year.

Sincercly yours.
Max

mf/

Pink.

M.D.

and

�</text>
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                    <text>December 26, 1968

Therapeutic Research Press. Ina.
Tenafly, New Jersey
Ganclansn:
Enclosod in our 0:30: for 1000 raprintn of the article
by Taylor,¢t 31., "Sign Dosa Chlordigzepoxide Therapy of Anxiacy”.

Please chip

300

reprints to:

Max Pink, M.b.
5 Eaat 102 Scrum:
Haw York City 10029

and 700 noprints

to:

Mr. Earnnn Vaiamnn

Squior Clinical Research Assaciatc

Hoffwan La Rocha, Inc.
Hutlmy, ﬂew Jersey 07110

confirming purchase order will be sent by the New York
Medical 6011030 on my behalf. Aftur shipping plausa send the statement
in full to me fox approval for payment.
A

Thank you

for your coopcration.
Sinceraly yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>Decembar 24, 1968

Dr. Vincent Dela and Marie Ryawandcr

Rocketeller university

new York 10021

Dear Vines and Harte,

I havc read the report in thc J.A.M;A. and the prograc:
report of the mathadana program and with ta congratulate both of
you for a haroic job wall done. Although I came into the narcotic
treatmnnt warld quite recently, I have experiencad many of the
administrutivc, valiticxl and idnolegical stupiditica that must
huva unrkcd yaur effarta; and ta~hnwn been so auacesatul, daspita
those hurdlcs. is indaad an achievumant. Congratulation:

!'

Our own atudias support yaur tapers fully, and I
have already cxvrassad tha opinion that the ptincipal battle has
beta won and that repair operations are ﬂaw neadad. We are
prcparing a summary of our vacant eonptrison at cyclazoctnc and
nathadone and this will be substantially supportive. Also,
in our EEG stuﬁien of heroin challengms. the duration of methadong
antagonism is longer than at had :nciatpatcd and
potancy increaaas

it:

with time.

‘

My

cougr‘tulations

on a job wall done.

Sineoraly youta,
Fink,
m
Ptafesaor of Psychiatry
M. BO

mil

�</text>
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                  <elementText elementTextId="102721">
                    <text>Hannah»: 24, 1968
Dr. Charles ﬂunn
Endo

Laboratories

Gardaa City.
Bear

9:.

Raw

York

Dunn,

Thank you for the extensivn literature on moltndona.
havn read
with grog: innatest, and tha data sugportn the
suggestion that malindonc 1. an attentive antipsychotie agent.
It; naval chcmianl structure recommends curly admission into
clinicnl pharmacology to providn an alternuca treatment for these

it

I

it:

patients not responding to «stabllshnd antiptyehctic drugu.

vagld 11k» to undertaka cliniaal trial. with mnlindanc.
Unfortunately. I do not hava an in-patiunt population of actively
psychotic patients for altnical drug trials. In our out~pationta
wa are (cannula; on thou: compounds which have had a prior EEG
aliasification stuay.
we

matcrial.

my thankl for the opyortunity to road this
best wishes for a auccensful Kaw Your.

Again.

my

Sincerely yours,
Max

Fink,

M.D.

Profasser of roychintry

mf/

�</text>
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                    <text>December 20, 1968

Dr. Edwin Dunlap
150 Emory

street

Attleboro, Mass. 02703
Dear Ed,
—.—,

cu

rn—m

I enjoyed the meetings in Freeport very much, and
wish to congratulate you and the other afficers for preparing
a fine program.

.

-m‘-vgs.

.
Mrs".

m

.

:

,‘wy‘y...’

.

.-a'

'2

xvi-Ulﬁs'

.A

It was suggested that I write to you for the necessary information regarding mambatship 1n the Academy of Psychosomatic Medicine.
I

would be

grateful for

any information

that

may

be

available.

Thank you.

Sincerely yours,
ﬂax Fink, M.D.

�</text>
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                  <elementText elementTextId="102723">
                    <text>December 20. 1968
Dr. Loon Rackaw
Franklin E. Rooaavalt Hospital
ﬁentrcse, New York

la N

Dear Dr‘

f

thkow.
Dr. Roubieek and I wish to thank you for tha splendid

welcoms and

interesting visit that

we

had

last

weak.

I

have

also

received the notes you sent ané haw. read chaos before sending them

on

ta

Dr. Freadnnn.

opportunity to: rasaatch at your hospital era indeed
I
will
encautnge Dr. Freadmnn ta establish the ralationahip
bright
which will paruit somber: of this staff :0 participata 1n the
special programs whiah the VA has aatabliahad. In reading the
reportn. I van most interested that half the patiento ware nude:
44 ycurs of age and that of theta, half taunincd less than two wecks,
suggesting thgt the population is more acute than was initially repr¢~
and

The

canted.

Again. our thanks fer year enthusiasm and I

Ftoaéman and the

visit

noon.

staff here will

trust

havu an occasion to discuss

Dr.

this

lineeraly yours,
Fink, M.D.
Prafesuor of ?aych1atty

Max

�</text>
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              <elementText elementTextId="36143">
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                  <elementText elementTextId="102724">
                    <text>December 18, 1968
Dr. ﬁcxean Cattoll, Editor
Journal of Clinical Pharmacology
and New Drugs

525 East 68th

ﬂew

Street

York, New York 10021

Dear ﬁr.

Cattell:

Enclosed is a copy of "High—Dose Tybamatc Therapy of
Heroin Dependence“ for your consideration for publication
in tho Jowmaz 05 Curated. ”modem! and New vauga.
This study roprosents part of our continuing evaluation

of treatments in opiate addiction.
Thank you

for your consideration.
Sincerely yours,
Max Fink, H.D.
Professor of Psychiatry

Mthp

�</text>
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                    <text>December 18, 1968
Dr. Walter Modell
Department of Pharmacology

Cornell University Medical College

1300 York Avenue
New York, New York 10021
Dear Dr. ﬁodcllz

Enclosed is a draft capy of "Electroencephalograms,
Mental State and Psychotropic Drugs” for ”Pharmacology

for Physicians". I am most grateful to Dr. Hollister and
yourself for your kind invitation, and for his critique.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>W

1'7, 1968

Dr. Richard Bmtmsn
Bepartment of Psychiatry
1m York Medical College
5 East 102M Street
New York, 24.15. 10089
\

Dear Dick:
The Unitad States mamas Laboratory in Baltimmm
called to say that the sample submittad contained no
THC. Their gnaw (and it was ml)! a guess) is that
, as thay have
W tablet naming of washed
seen aimlw amen befom.

W1

Sinaemly

yam,

rm Fink, 24.23.
Mfessor of madam
Hf‘mr
.

.
w

“warm."

ac: Er. Alfmd
rmﬁ-me

t“:

law'vﬁ-zﬁw‘1..:n1/-‘&gt;=w-JT;vu,

a

H.

mm

�</text>
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.—,....,.A

..

December 17, 1968

Honorable Norman P. Lent
Chm.,

Joint

Committee on Health

State Capitol

Albany,

How

York

Dear Senator Lent,

I am writing to roquest sarious consideration to the
potential hassrds in tho proposed amendmont to the public health
law in relation to human research (8. 4015A, A.5586A). I have read
the proposed amendments and find them too restrictive in their

text with regard to the continuation of research;
definitions of 'roscsrch'.

and too vague

in the

Since 1952 I havo been engaged in rosesrch in montal

illnesses. with specific sophssis on treatmouts using biological methods.
First at Hillside Hospital in New York (1952~1962),thcn as tho
director of tho Miaaoori Institute of Psychiatry (1962~l966) and

at the New York Medical Collage whore I am Director of the
Division of Psychopharmacology and Drug Addiction. I have found that
none of the techniques which are needed in the study of man van be
carried out in animals. neural illnesses soon peculiarly human
frailtieo, and their study, while raconmonded it animals by others, are
totally unsuccessful. Progress in treating the mentally ill seems to
cons only from studies in patients, as with convulaivo therapy,
the many now drugs, and recently, in the treatment of opiate addiction.
now

At present, our emphaais is in the biological troatment of
opiate addicts. The peculiar nature of the illness, and the methods
which are now useful ( methadone maintenance, cyclsrocine and nsloxone
antagonism) have been developed in patient studios.
The proposed law suggests that all studies will have to be
cleared by a committee, half of whom will be laymen. Considering the
difficulties with methadone maintenanco with Federal authorities, and
initially with state authorities, I am sure that such a committee will
prevent any research which at the timo may be considered hazardous,
thereby preventing progress.

Lot mo cite a specific example. In our studies of mothadouo
inttho traatment of addicts, we have measured the affects of methadone
on brain function and find that the changss ara so like some that
we have found useful in the treatment of severe schizophrenic
patients,
that we proposod a study of methadone in the therapy resistant psychotic

�Senator Lent

December 17, 1968

2

pationta at our institution. The proposal was carefully reviewed
by our College committees and approved. 0n referral to the Commissioner
of hospitals. howovor, the proposal was dioapproved since mothodone
is considered an dddicting drug. It is strongo that laymen are
for when all hopo has been
willing to allow the severe montally
nbandoned after all other mthodc have been tried, to forgo a potential

ill,

therapeutic benefit, out of fear.

All research must be daring to be oudcasaful. All human
research can ho monitored by our poets, and the present committees
have shown themselves to be useful. Since their introduction during
tho post foo years at the urging of the Federal granting agencies,
it aaams premature to antablioh another mechanism bofore this one is
‘fully established.
Specific objectiona to the logialntion are as follows.

will consint of laymen in the majority. Modern
too
complcn
to be rovicwed by tho laity except when one
tachuiqcos are
hoscl
no
oxpocts responses
prejudice and emotion. Research cannot be
omotion
and
be judgod by roaaon«~ whcrovor poooiblel
should
by
judged
The Comoiosion

will oit far away from the site of tho
rosoarch. It goons that there will ho only one full time mentor, and
it is inconceivablo tact tho alto of the roooarch. tho qualifications
of the investigator, and the Quality of the protective devices can
The Commission

be monitored omcoyt in tho locale ohcro the study

is done. If a committee

of visitors is established, than the device will be overly cunbersono
and oxponoivo.

conflict hatwocn reoearohy at poorly dofinod, and
medical
treatmont as
practice, is not rcoolvod by the logiolntion.
If I treat a patient with a new treatment will this ho exempt if
I on paid for it as part of medical practice; but not exempt if
done for no fee as part of a research program ?
The

The problom of consent has been adequately discuoood
Fodoral
in the
legislation of a tow years ago. Thorn are special
problems in dealing with the mentally ill, and the propooed atote
legislation does not dofino the safeguards which experience has shown to
be useful and necessary.

There are othor problems which are not

clarified in the

bill. It is regrettod that tho legiolnture finds it necessary to
propose state legislation io.an «tons where existing legislation.
if adequately administered. would be most odoq’nto to protect our
fellow citizans and ourselves. American research has been in the
forefront in all fieldo except in the care of the mentally 111. Most

of the modern advances in their treatment have coma from Europe. In
part this resulted from our ovcrinvoatmont in psychotherapy; and
in port. from the restrictions placed on research in our institutions
for the acuto mentally ill. The addition of this burden, on oxemplified
in tho proposed lcgiolation, will handicap Amorican research even
further- for such legislation is unlikely to remain restricted to
our stotc. since we have been a bollwoathor state.

�Senator Lent

December 17, 1968

3

In writing this

letter, I

on

acting

on my own

behalf

as Director of the Division of Psychophnruaoology and Drug Addiction
of the Department of Psychiatry; and as tho Exocutivo Diroctor
of the International Association for Psychiatric Research. Inc. The
IAPR was established in 1967 to provide a nochonisn whereby collaborative
research could be undertaken in othor localities where the restrictions
were less stringent. Because of limitations in committee actions
at the Federal level, we have undertaken some important research in
trottnont of mentally
in Istanbul, thoroby confirming studies
We hnvc also begun a study of
from
France.
originally reported
marijuana in Greece since the restrictions imposed on the study
and sunply of this impotttnt agent in the United States have been
so great that wn havo had to go through multiple oomnittons and
18 months delay before undertaking ouch studios in New York.

ill

Your consideration of these comments

is appreciated.

legislation will, in our opinion, do more harm to our
citizens not ouroolvos than any potential good that may be imagined.
Your oomnittee's disapproval is roquooted.
Tho proposed

Sinceroly yours,

Fink, PhD.
Profossor of Psychiatry

Max

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Yellow Springs Instrument Company
Yellow Springs.
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record them as rapidly as possible. We
are equipped with a Grass Model VII polygraph.
May I request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele-

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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_.

my».

-«-,_.-

»

...,,.- .q‘.

.

.m;

5.. «pt-.11

an, m.” ”or, "FKJ:
w—

u.

,4:.‘,:’

s,

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M—z'vw

December

'\ '

raw-«um: .

l2.

-—..,—./

.

-,

~.-~am--.n

-.'v'

1968

Yellow Springs Instrument Company
Yellow Springs,
Ohio
Gentlemen:
I would like to record temperature changes in man
from body surfaces such as the inner thigh or earlobe
and orally. The changes will be small and we would like
to be able to record than as rapidly as possible. we
are equipped with a Grass Model VII polygraph.

request your recommendations for the appropriate
thermistor probe for these applications. we will require
two probes for each application and an appropriate tele~
May I

thermometer.

Thank you

for your recommendations.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>December

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx.

New

York

Dear Leon.

discussed with you. I am enclosing a paper “Newborn
Sex Ratios Associated with Pre— and Post- Partum Process
Schizophrenia" written by Dr. Taylor who is one of our third
year residents. The problem is either a very important one.
as I think it is. or an interesting footnote.
As I

I would be pleased if you and Dr. Gallagher would read
and I would like to arrange an opportunity for us to
get together to discuss this further. Please call me as soon
as you have had a chance to read this report.

this

The report has been submitted to Science and until it
has been accepted for publication. I would ask you to use your

greatest discretion in discussing this report.
Sincerely yours.

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>ll,

December
Miss Violet E. Denison
Associate in Admissions

l968

-

Teachers College Columbia University.
New

York,

New

York l0027

Dear Miss Denison:
Miss Karliner was appointed to our department in
June l968 as a summer research worker and returned to
school in September l968.
She devoted her tine to the study of memory changes
in psychiatric patients. most of whom were elderly, in
our study of the convulsive therapy process. This study
is in progress at Gracie Square Hospital, supported by
the International Association for Psychiatric Research, Inc.
In her work Miss Karliner was supervised by Dr. Rhea

Dornbush, Ph.D., but I had the opportunity to meet with her
twice weekly. Both by my direct observation and by her
reputation at the hospital. she exhibited great facility
in dealing with the severe mentally ill - some of whom were
confused and most irritable. DeSpite the stress of dealing
with difficult patients, she always maintained her

able to stimulate cooperation even when
difficult. She was well liked by her associates
it
and achieved a good reputation among the staff. She is
emotionally mature. both for her age and on an absolute
standard.

equilibrium and
was most

was

I am pleased to
her chosen career.

recommend

her highly as

a

student in

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>December 11. 1968
Mr. Arnold Canter
Andrew Stuart Associates,
P. 0. Box 325

Purchase.

New

Attn: Mrs.

Ltd.

York 10577

E. Mascia

Dear Arnold,

Foiiouing is a list of employees now being paid by
the International Association for Psychiatric
Research.
for whom coverage is requested under the Workmen's
Compensation and Disability Insurance:
Salar
Dr. Richard Abrams
SS? 065-30o0071

Pauiine

Da

Costa

Psychiatrist

$1257mo.

054-44—3714

EEG

Tech.

186.67/mo.

R. Dornbush, Ph.D.

118-32—5789

Psychologist

250.00/mo.

J.

078-34-0868 Resch. Nurse

350.00/mo.

Suzanne Kraft

092-40-0020

EEG

Tech.

227.50/mo.

Lynn D. Kyde

125~38-2353

Resch. Asst.

390.00/mo.

S. Horwitz

K.

Peiczynski

is

P. 0. Box 269. Great Neck,

497-44-2537 Secretary

Please note that the address of record for the Association
New

York 11022.

Sincerely yours.
Fink,

Mex

M.D.

Executive Director

MF:kp

50.00/mo.

‘

�</text>
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                    <text>December

ll,

1968

Honorable Wallace Groves

President.

Grand Bahamas

Port Authority
Freeport. The Bahamas

,

Dear Mr. Groves:

visit to Freeport, attending meetings of the
of Psychosomatic Medicine, I was favorably impressed
by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
In a recent

Academy

that there

was a need

fer additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
We have talked of possibilities of expanding our programs
to other communities. to allow for the insights which come
from comparative studies.
I

do not know what

facilities for psychiatric care are

if

there is either a need for or
an interest in the development of a community mental health
be able to fulfill such
progran, it is possible that we may

available in Freeport, but
a

serv ce.

would be pleased to hear from the approoriate agency
of the Authority regarding this suggestion. Let me take this
Opportunity to congratulate you on what appears to be a
visionary and exciting program.
He

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Becember

ll,

l968

Honorable Wallace Groves

President,

Grand Bahamas

Port Authority
Freeport, The Bahamas
Dear Mr. Groves:
In a recent

Academy

meetings of the
was favorably impressed

visit to Freeport, attending
I

of Psychosomatic Medicine.

by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
that there was a need for additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
we have talked of possibilities of expanding our programs
to other communities, to allow for the insights which come
from comparative studies.
I do

not

know

what

facilities for psychiatric

if

Care are

for or
there is either
health
mental
an interest in the development of a connmnity
program, it is possible ' that we may be able to fulfill such

available in Freeport. but
a

service.

a need

.

we would be pleased to hear from the appropriate agency
of the Authority regarding this suggestion. Let me take this
opportunity to congratulate you on what appears to he a
visionary and exciting program.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>December 11, 1968
TO

WHOM

IT

MAY

CONCERH:

Mr. Staniey R011 was empioyed as a pregrammer on
January 15. 1968, to participate in our research program
app1ying digitai computer methods to c1inica1 psychiatry.
a

Mr. R011 devoted the majority of his time to interfacing
217 disp1ay scope to the IBM 360/40 and programming a

CBC

behaviorai rating sca1e using this device. During the initiai
months we had some difficuities with hardware but as these
were so1ved the programs were comp1eted.
Mr. R011

resigned effective December 15. 1968.
Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                    <text>ﬁecember

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx, New York

Dear Leon,

“Newborn

a paper
discussed with you, I am enclosing
Process
Pertum
Post»
and
Pre~
Sex Ratios Associated with
of
our third
one
who
is
Schizophrenia“ written by Dr. Taylor
is either a very important one,
year residents. The problem
interesting footnote.
as I think it is. or an
Dr. Gallagher would read
I would be pleased if you and opportunity for us to
arrange an
this and I would like to this
Please call me as soon
further.
discuss
to
together
get
chance to read this report.
As I

as you have had a
Science and until it
The report has been submitted to
ask you to use your
would
I
has been accepted for publication, this report.

greatest discretion in discussing

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>[WW—
I

I

-,

_

__—wmumw.w_mr-

December
Dr. Stanley
York,

Dear Dr.

l968

Feldstein
Street

255 West 88th

New

ll,

New

York l0024

Feldstein:

The International Association for Psychiatric Research
is pleased to have you as a member of its research staff
at an annual salary of $3,000.00.

to having you participate in our study
both
lDan
Street and at Gracie Square Hospital.
at
programs
I look forward

Sincerely yours,
Max

Fink, M.0.

Executive Director

Mszp

�</text>
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                    <text>Decadbmr 10, 1968
Dent 3111,

I plan to be in Miami on Dacembar 12~13. and as I havu to
be in Puerto King on Daccmber 18. that: is a pessibility I will stay
ever. For that reason, I hesitate to make a apacitic date to discuaa
the fenfluraminc extancab study. If I do return on Sund‘y, Dacamber
15. I would like to man: with you on Eanday, attar your athur appointnnnc
or on Tuesday.
ﬂaw York

If I can

Hilton.

maka

it.

I will leava a message far you at the

In the aaauwhile, I will rand tha matarial you sent
and will discuss it with Br. Ittl.
My

best regards.
Sincerely yours.

”3: Fink ’

H. Do

Professor of Paychintry

:2.

William Tabor

A.ﬁ. Robina Co.
Riehmond, Va.

�</text>
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                    <text>December 6, 1968
Dr. Henry W. Elliott, M.D.
Annual Reviews, Inc.

4139 El Casino Hay
Palo Alto, California 9e306

Elliott:

Dear Dr.

It

was indeed a pleasure to prepare a review of EEG
and human psychopharnacology. The question in your letter
of December 2 is unclear. The nest suitable reviewers of
the subject of EEG and human psychopharnacology are Charles
University of
Shagass, Temple University, Turan H.

Itil,

Missouri School of Medicine, Missouri Institute of Psychiatry,
or Carl Pfeiffer. New Jersey Rents-Psychiatric Institute.
For a

or

Leo

critique, you could approach Dre.
Hollister.

A. Wikler (Lexington)

for other topics that should be reviewed in subsequent
the question, I believe the effects of
drugs on the averaged evoked potential in man and animals
would be of great interest. Dre. Ed. Domino, Charles Shagass,
or E. Roy John could, in my opinion do such a review handsonely.
Dr. Shagass has completed a review in men.
As

if that is

issues,

EEG, drugs and sleep is a most important
I do not think there is sufficient material yet
for a satisfactory review, but I may be incorrect.

The

new

area.

subject of

The EEG changes

with drugs as measured by amplitude

interaction was covered adequately in 1965 and I do not think
that sufficient new data has been published to warrant another
review at this time. The citation is Goldstein and Beck.
I trust this is responsive. Thank you once again for
kind
invitation and I trust that the review is up to
your

your standards.
'

-

Sincerely yours,
MIX Fink. MOD.
Professor of Psychiatry

Hkap

�</text>
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                    <text>December 6, 1968
Dr. Henry H. Elliott, M.D.
Annual Reviews, Inc.
4139 El Camino Way

Palo Alto, California

9&amp;306

Elliott:

Bear Dr.

It

was indeed a pleasure to prepare a review of EEG
and human paychopharmacology. The question in your letter

of December 2 is unclear. The most suitable reviewers of
the subject of EEG and human psychopharmacology are Charles
Shagaua, Temple University, Turan M. Itil, Univcroity of
ﬁisaouri School of Medicine, Missouri Institute of Psychiatry,
or Carl Pfeiffer, New Jersey Nauro-Poychiatric Institute.
For a

or

Leo

critique,

you could approach Dre. A.

Hollistor.

Hitler (Lexington)

for other topics that should be reviewed in subsequent
the question, I believe tho effects of
drugs on the averaged evoked potential in man and animals
would be of great interest. Dru. Ed. Domino, Charles Shagass,
or E. Roy John could, in my opinion do such a review handsomely.
Dr. Shagaoa has completed a reviaw in man.
As

issues,

if that is

subject of EEG, druga and sleep is a most important
I do not think there is sufficient material yet
for a satisfactory review, but I may be incorrect.
The

new

area.

The EEG changes

with drugs as measured by amplitude

interaction was covered adequately in 1965 and I do not think
that sufficient new data has been published to warrant another
review at this time. The citation is Goldstein and Back.
I trust this is responsive. Thank you once again for
kind
invitation and I trust that the review is up to
your

your standards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>iii

December 5, l968
Dr. Harvey Tompkins

.

Chairman. Panel on Neurology and Psychiatry
Health Research Council
Department of Hospitals

l25 North Street

New

York,

New

York l0013

hear Dr. Tompkins:
The HRC review of the proposal "Methadone in the Treatment
of Chronic Active Psychosis" was read. I am taking the opportunity
(as the suggestion of Dr. Lehr) to acquaint you with our progeam
and the reasons for our interest in this compound.

This study is part of an evaluation of centrally active
compounds to determine what relations can be defined between
drug induced EEG changes and clinical behavior in man. Most
commonly used drugs have been assessed (see review) and we
are non attempting predictive studies. Examinations of

cyclazocine. fenfluramine, thiothixene, and sulthiame have
been completed and those of doxepin, nalouone, marijuana, THCs
and heroin are in progress.
Methadone is widely used in treating opiate dependence.
have found no useful reference to its use in psychosis.
Methadone evinces EEG characteristics that warrant the prediction
that its use will be associated with a sharp reduction in active
psychosis. If true. the EEG~behavioral theories will receive

We

some affirmation; if not true. the theory will require reasseSSment.
This project is not a simple clinical evaluation, as the reviewers
imply, but a test of this hypothesis. We have carefully justified
each experiment (especially this one) to the hepartment Chairman
and the Research Committee of the Colbge.

is part of

an RIMH supported program, “Quantitative
Studies in
Psychopharmacology” ~ supported since 1962
and
in Missouri
since l967 in New York. A copy of the relevant

EEG

The study

Human

portions of the grant application, as completed in l966, are
enclosed.

�1 .v.-n .. ..
‘Vﬂ-VI,~‘PV—--p'-wr-Iu..-vA~l--W~‘~fm:‘

«um.I'm—r . .nu Jr
.—

.

.-

.

v

.v yawn-up”
.

w .7,

i

w
era...

c --

-

"an."

Dr. Harvey Tompkins

The

v33?

.4.

:r‘wwuecvn—lgnvwn'u‘m&lt;

wiry;

um.“

Win-4 cm‘tw.-.

-

«:n-“vum—

,w

December 5, l968

-2~

rejection of this project, justified by conventional
justice neither to the Panel, nor our

catechisms does

scientific progress, nor the treatment failures who may be
helped if the method is successful. I trust the Panel will
have an opportunity to review

its

recommendation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
cc:

..

Dr. David Lehr
Dr. Alfred M. Freedman

u;

u

�</text>
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                    <text>wrrw-v-wya—u.

.

c.

- .7 ..

i

s

w

.7.woman.”w2.7 _

-.-

-Fww at-)r .. m.
.

.

.

.

;

-1. av.
n

‘

. _..
..

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.

.

.

...--»~--

w

m

._

_

“an"

.-7;-»;:~-u.vu-

‘

V

‘_w‘u_‘_‘_wv__

7‘WH”

December 5. l968

Dr. Richard E. Gordon
Acting Medical Director
Computer Sciences
J. Hillis Miller Health Center

University of Florida

Gainesville, Florida
E

3260l

Dear Dick.

g

i
.

"rm-v

wanna-Juana;

gar

.

Enclosed are the specifications for running our period
program on the IBM lBOO. It runs under the Time
Sharing Executive System (TSX) and requires a minimum of.
l6,000 locations of core storage. The associated disk file
requires 205 sectors of 23l¢ disk storage. The following is
a list of the routines required for this system and a brief
statement as to the purpose of each one;

analysis

t'WN'ranrrn'ﬁ-J

,Wmu-

I'mW‘VW/

ﬁrvrn

108-71?

‘r-VW

- This is the main program which reads input
parameters, initializes process and error indicators, prints
output, builds disk file and calculates means and standard
RESET

deviations.

an assembly language subroutine which samples
analog input and keeps zero cross. first derivative and amplitude
INPUT

vﬁnvnw'n

.1
2:
v

mnw-n‘bw’x’w’wxe'ﬂn-Iwrn-

W

~

is

data.

- delays sampling to allow the technician time to
previous sample.

DELAY

artefact

MYERR

- sets [/0 error indicators in

LOGBL

- writes

CONVP

- rounds numbers for printing.

w:

ar

'

on

CONNOR.

the typewriter the number of

instructions executed during each epoch.

X10 BLAST

.

_

V

.7.”

..

K

ﬂ

m"

)

�f?

E

E

-2-

Dr. Gordon

December 5, l968

FLASH flashes a light on the EEG console and waits
for the start button to be depressed before returning to RESRT.
gay - is the analog interrupt routine.

SETUP ~

sets the address for the timer interrupt.

The coreload is built as SIGMA. Sampling rate. epoch length,
analog input point, number and frequencies of bands to be analyzed
are all variable parameters entered through cards.
PAPRL from the raw

is the

name

output.
build the core load:
EEG

of the program which calculates statistics
following routines are necessary to

The

statistics
statistical data

PSTAI,~iis the main program which calculates

prints out either both the
or just the statistical data.
and

raw

data and

line

39939

~

rounds raw data and

DINIh

~

reads one record of data from the disk

prints

one

sent separately. If
additional help, please call.
The cards are being

we

on

Fink. H.D.
Professor of Psychiatry

Mszp

file.

can be of

Sincerely yours,
Max

the l443.

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                    <text>‘3‘

December S. 1968
Dr. Richard E. Gordon
Acting Medical Director

uter Sciences

J. Hillis Miller Health Center
University of Florida

Gainesville, Florida

3260l

Dear Dick.

Enclosed are the specifications for running our period
It runs under the Time
analysis program on the IBM 1800.
and
(TSX)
requires a minimum of
Sharing Executive System

disk file
l6,000 locations of core storage. The associated
The
is
following
disk
storage.
requires 205 sectors of 23l¢
and
brief
a
system
this
for
a list of the routines required
statement as to the purpose of each one:
- This is the main program which reads input
parameters, initializes process and error indicators, prints
output, builds disk file and calculates means and standard
RESRT

deviations.

- is an assembly language subroutine whichandsamples
amplitude
and keeps zero cross. first derivative
analog input
INPUT

ata.

- delays sampling to allow the technician time to
artefact previous sample.
DELAY

sets l/O error indicators in

COMMON.

MYERR

—

LOGBL

- writes on the typewriter the number of

instructions executed during each epoch.
CONVP - rounds numbers for printing.

x10 BLAST

�‘

Dr. Gordon

-2-

December 5, 1968

- flashes a light on the EEG console and waits
for the start button to be depressed before returning to RESRT.
FLASH

the analog interrupt routine.
w - -is sets
the address
the timer
CAN

for

SETUP

interrupt.
Sampling rate. epoch length,

The coreload is built as SIGMA.
analog input point. number and frequencies of bands to be analyzed
are all variable parameters entered through cards.
PAPRL

-

from the raw

is the

name

output.
build the core load:
EEG

of the

which

calculates statistics

The f0] program
owing routines

are necessary to

PSTAT
is the main program which calculates statistics
prints out either both the raw data and statistical data
or just the statistical data.
—

and

data and prints one line on the 1443.

ROUND

- rounds

DININ

- reads one record of data from the disk

raw

The cards are being sent separately. If
additional help, please call.

we

can be of

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

file.

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                    <text>A

w.

u

w.

.4

.“

-v—m

«Va-1.....-

vvarm-m'rm—w.

wwrwv-wu

awn—”rpm

December 4, 1968
wrzw'mrtrwv

nyx-Wiw'uﬂr'fina

v:

Dr. Arnold Kendall
Deoartuont of Psychiatry
Univ. of California at Irvin:

Irvine, California

J’f-‘l'llbr

r
H

.w

car—

Dent Arnold,

in"?

.

“.mu'rfz

.

.

rm”:

.
V

A; we diocuosod, I am enclosing thrco abntracts for the
consideration of the Fsogran Committee of tho Boeioty of Biological
Psychiatry.
and
and

will

The abstract on cetubral reactivity in the one toquostod,
be a review of tho pant for your: work in our laboratories

others.

The unilatera1~bilatora1 EC! is submitted to bring to
the attention of the Socioty son. of the new tindinga in this
reappraisal of the convulliva thetopy protein.

The maternal schizophrenia—sex of offspring report is
tho most important, potentially of the three; and probably fita boat
into the theme of experimental roooaroh in schizophrenia. I am so
impressed with the data that I on oncouraging thoso young residents
to write a definitive report and uubnit it for the prize contest of

the Society.

for a

Thank you for your considerution, and
moot successful program.

my

best wishes

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

M33

mil

�</text>
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                    <text>-'

mun

.w ~‘Y"V\‘!

warm-myur-n»:

w

:

x~151§~n~v&gt;m4w£aﬂ yo. aw.

«n» .-.v

.

x

_

,t,

,.,

,

..--.

3—»

—_‘V‘_-'~,11'.'u

-

r..._;-,.g.—

..-

..

._..

.

ym;

, Y7

.,

December 3, 1968
Dr. Savoringhauae , Editor

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New York

Dear Dr. Savoringhaua:
We are pleased to submit the report, "Liquid Butaporazinc
in the Treatment of Chronic Psychosis in a Hantal Health Clinic"
for your consideration for publication in Current Thorageutic

Research.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>E

t

E

i

December 3, 1968

1

»

i
:
{

Dr. Peter E.

Siegler,

M.D.
Company
Haines and McCallum Streets

The

National Drug

Philadelphia, Pennstlvsnia
Dear Dr.

19144

Siegler:

is a draft protocol for the study of aletamine.
divided into three parts, which are successive
approximations of the analysis of the problem.
Enclosed

It is

The initial EEG trials are designed to test the dose and
time relations of a single dose as it affects the EEG profile.
These trials provide the basis for the definitive classification
trials which are comparative with knoan standards. As soon as
the classification is defined with surety, a clinical study can
be designed and undertaken in the appropriate papulation.

this procedure may be greater than the conventional
open or double-blind clinical trial, it has some distinct
advantages in providing the conventional data as well as the
While

theoretically significant neurophysiological profile.

I will be pleased to have you visit once again to discuss
these proposals in greater detail and wish to thank you for the
opportunity to read this interesting material.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>we, ,7

—;

w‘ (

winery-en

.nﬁ-r»

..

av.v--v.~-w»—.r .. --

*-.-\

..:,-,

w—r

y,

v77". 7-9—7 '

'rw'wvv

December 3, 1968
Dear Turan and

Ali,

Enclosed are draft copies of the summary report
of the fluphenazine experiences, as sent to Dr. Rothman for his

book, "Changing Patterns in Psychiatric Care".

While I anticipate
comments, you may assume that it will be published
as submitted. As soon as I know the publisher, I will let you know.
some

editorial

My

best regards.
Sincerely yours,
Max

mil

Fink,

31.1).

�</text>
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                    <text>December 2, 1968

Stetler, President
Pharmaceutical Manufacturers Association
Foundation, Inc.

Mr. C. Joseph
1155

Fifteenth Street,

N.W.

Washington, D.C. 20005
Dear Mr.

Stetler:

During the past few years

we

have

in clinical psychopharmacology in this

an unusual

a program
Department of Psychiatry.

is one, Dr. Arthur M. Zaks, who has demonstrated
talent in clinical pharmacology, both as a resident

our students

Among

established

physician and since July as a Research Fellow.
encourage additional training

scientist.
that

~

and

we

wish to

his development as

a research

am writing to request information and application forms
may be available for our participation in the faculty

I

development award program of the
Thank you

PMAF.

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>t.

J’K'a—

.,

—.—s-_'_:

e

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
The Provincial Hospital

Postal Station
St. John,

New

B

Brunswick

Dear Dr. McLean:
Dr. Haque was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

‘

I found him cooperative, alert, and enthusiastic. He carried
his responsibilities well and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. He was among the
better residents which the hospital produced.

m..-

"11"

1-"

mm"...

I

am

pleased to

is qualified.

recommend him

for

any

position for

ny—g-v

7

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

which he

�</text>
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                    <text>December 2, l968
,,
:1

Dr. Lee

mw-mm—z

Hollister'

Hospital
Palo Alto. California 94304
V. A.

.

Dear Leo.

t

wwmvw—

Enclosed is a draft copy of the presentation for
Pharmacology far Physicians. 1 have tried ta make it less technical,
and feel that I may have succeeded in the second half only. It
represents the synthesis of the work of tha past decada from many
laboratories and while I believe it to be true and accurate, there

is

much

that will raise

some eyebrows.

If there are portiohs that are unclear. or changes

mm

«

w

wish to make. please feel free to suggest them Or,
please sand on to Dr. Madell.

you would

if acceptable.

van-y.

n
vwl

Many thanks for the invitation and the Opportunity to
reformulate these thoughts.

Sincerely yours,

awt'an-uvrwvmrp—xwmuzn-uv—wmuc—n‘

Max
I

‘V'JIGX'CS

-

u
M

‘mw‘d'

mam

'-

.mxmr'rwmw’mnwmﬁwwmﬂmw7.

mum—w

.v‘fm-yﬁ

mf/

Fink,

H.D.

�</text>
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                    <text>wermrnrmwu

December 2, 1968
Dr.

J.

Douglas McLean

Director of Edication
Provincial Hoapitel

The

Postal Station B
St. John, New Brunswick
Dear Dr. McLean:

Dr. Hague was a resident physician at the St. Louis State
Hospital during l965~1966 and elected as part of his training
program, to participate in research studies at the Missouri
Institute of Psychiatry. His work was directly supervised by
Dr. Turan Itil, and my contact with him was limited to the
reports which he presented and the occasional research meetings.

alert, and enthusiastic. He carried
and was responsive to the needs of the
patients. He was of good spirit and enthusiasm. ﬁe was among the
better residents which the hospital produced.
I found him cooperative,

his responsibilities well
I

am

pleased to

is qualified.

recommend him

for

any

position for

Sincerely yours,

371m

(a.

r‘w-Wznhy

Max Fink, M.D.
Professor of Psychiatry

which he

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                    <text>wmnr

.m-

'1

-"?~-':“

awn»;

'I‘R-VJV'Q

\-

w'I-na-

~

~ "l'VzH

.-

-

.‘r'.r“--3v".\

u

'wm ,

“-1“... sun r

nr'iw‘“ .3...

-

-'r"o'"7" .. an:

‘

ava- "mgr-~-

:.~-~.:.~.&lt;

7:.

.

WWIdlIb‘MK’u‘K'

ww.

'IA" vuw-«.uwv:=r

December 2, 1968
Dr. Reginald Bickford

Mayo

Clinic

Rochester, Minnesota

Dear Reg,

I

pleased that IBM has indicated a willingness to provide
for the 1969 meeting in San Diego. To provide an
Opportunity for our programs, I am attaching a capy of the
configuration of components with which our 1800 is equipped.
It is my understanding that they will provide this machine
if requested.
an

IBM

am

1800

I suggest that

you write to Dr. Wayne Jostrand, Marketing
Medical
Services, 475 Northern Blvd., Great Neck,
Representative,
New York 11021, indicating the time and place of the 1969 meeting,
and your willingness to exhibit this machine.
May

Perhaps, an announcement in the next newsletter from the
Committee on Arrangements as well as memoranda to the EEG Journal
and Trace may provide you with other workers in the field who may
wish to demonstrate their programs. As an initial guess I would
suggest you contact Ernst Rodin at the Lafayette Clinic, Niel Burch
in Houston, Walter Christ in Chapel Hill, and Bernard Salsburg in
Tulane.

I trust this is helpful.
Sincerely yours,
Fink, M.ﬂ.
Professor of Psychiatry

Max

MF:kp

-

w

.

-.

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                  <elementText elementTextId="102749">
                    <text>December 2. 1968
Mr. C. Joseph Stetler, President
Pharmaceutical Manufacturers Association
Foundation, Inc.
'

1155

Fifteenth Street,

Washington, D.C. 20005
Dear Mr.

N.w.

Stetler:

During the past few years vs have established a program
in clinical psychopharmacology in this Department of Psychiatry.

Among

is one, Dr. Arthur M. Zaks, who has demonstrated
talent in clinical pharmacology, both as a resident

our students

an unusual

physician and since July as a Research Fellow.

we wish to
encourage additional training and his develoPment as a research

scientist.

I am writing to request information and application forms
may be available for our participation in the faculty
development award program of the PMAF.
that

Thank you

for your cOOperation.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>December 2, 1968

Dr. Robert E. Dixon, Director

Profeslional Services

Roche Laboratories
Nutley, New Jersey 07110

Dear Dr. Dixon:
Some months ago you were kind enough to send my associate,
Dr. Jovan Simeon, a copy of the "Compendium of Psychopharmacotherspy'
by Walter Poeldinger.

and

I

Dr. Simeon was kind enough to share his copy with me recently
have used the material in one section in my course in

this College.
that this volume is not available

psychopharmscology at

I

presume

bookstore and so

available, for
Thank you

my

am

writing to request

use.

a copy,

if

thgough our
one is

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

still

1

�</text>
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            <elementTextContainer>
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                    <text>Novumber 30, 1968

Dr. Dean E. Wooldridge

California Institute of Technology
Borkolpy, California
Dear Dr. ﬂooldridgc,

I

am

writing to roquont permission to use a paragraph

from your volumo, ﬂochanictl‘ggg , II an introduction to an article
that I on writing at the request of
tho editors of Pharmacologz for

thoioians. I wish to quote tho paragraph ending the summary of
Chapter 14, on page 156.

I have read the thrac volume: of your views of
biological science with considerable intorost. Our own studies,
devotod to nonsuromnnt of tho changea in brain function and in
behavior associated with the administrntion of drugs and biological
trnataont of the mentally ill, have led on to the conclusion that
small alterations in cerobral chomiutry do, indcod have profound and
monournblo

affects both

on the scalp rooordod EEG and on interporaonol
revicu for which I requcot permission to quote your
summary, is the result of out atodies and those of others and in
consistent with your message.

behavior.

The

Thank you

for your oooporation,

intorelting expositions.

and

congratulations on your
Sincerely yours,

‘,

,o.w;wk...v

Fink, M.D.
Professor of Psychiatry

Max
"

‘
-

’7”

“33"“

'-"-’-

WW

:

-‘=

"

w‘v‘r

2"”-

Wan-er-er-v

mf/

�</text>
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              <elementText elementTextId="36463">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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  <item itemId="3647" public="1" featured="0">
    <fileContainer>
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                  <elementText elementTextId="102752">
                    <text>November 30, 1968

Dr. Shervert Frazier
Committee on Program
Washington, D.C.
APA

Boar Show.
Thank you for your kind letter, indicating that tho
Committee had too many fine articles to present in the 1989
meeting, to be able to include this one.*

I recognize your difficulties. and am writing to bring to
your attention the unusual significance of roporto of this kind for
our society. Tho.presoot trend is for more and more governmental
rootrictihn on research, and we have had to undortako this study
in a foreign country precisely because we were unable to file on
IND

here.

Since completing this study, and the political conooquonooo
of such a venture are grout, we hovo been able to file an IND hero
and presumably can undertake the study. The problem still oxiats,
however, and an opportunity to shoro the difficulties with the
memborship was the mission of the report.
Perhaps there will be another opportunity at the wanting
to discuss the FDA~rosoarch rolotionahipo, or to describe the unusual
(indings of thin otudy. Incidentally, it in not trivial to oboervo
the safe application of a treatmont at 100 timoo the ooooptod
dosage range.
Thank you

for your kindness.
Sincerely yours,
Max

Fink, H.D.

Rofz*Vory High Dose Fluphonazino Therapy of Psychosis

�</text>
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                    <text>a

”w".

A

November 29, 1968
Mr. Alden Bober

Acting Chief Chemist
U. 8. Customs Lab.
103 3. Gay Street

Baltimore, Maryland 21202

.n~p—rvw-,-

«rug:

:swwr-n-rn

-«.-

F1."

ww..«.r—

n
.

"‘;P'.:—c":n.'aﬂmv-"-

a-wc

Wr

v-rwafP-:WWW';rm-ﬂ“

ANW~\5,A~

wmrl

v.

Dear Mr. Bober:

"

)4»

three samples, individually labeled, of

presumed marijuana substances. Ibo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIHH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>November 29, 1968

Dr. Thomas V. Ksicher, M.D.
Geigy Pharmaceuticals
Ardslcy, New York

last

Dr. Koichct,

I hsvs read the material submittcd regarding GP 41299 with
bclicvs that we can participate in a number of studies
interact,
consistont with your goals of establishing tho potsncy and clinical
safety of this compound as a hypnotic and/or a minor tranquillizcr.
As we review the available dots. the compound hss been touted primarily
as a hypnotic and no effort is described to ascertain its other possible
and

activities.
like to

Thres types of studies are suggested, and whilc one would

rcccumcnd each of then, neither time not
personnel would permit this to he demo.

1.

EEG

profils analysis:

The EEG

available stuff

profile of

GP

41299 can

in volunteer subjects, on single oral trials. and the
spectra can be compared to a standard sedative (snobsrbitsl or
diatopcm) and to other compounds as imipramino. fsnflursminc sod
chlorpromszﬁnc. to ascertain its clinical similarity to thesc agents
at the dosages tested.

be soscsscd

2. Comparison with chlordistopoxido in the therapy of
clinical anxiety: The use of ODE as a standard in s mantcl health
clinic population has become accepted, and as hsvs undertaken studios
of other minor tranquillizsrs in comparison with this compound. A
similar study of GP 41299 should be considorsd.
3. Soporific activity in opiate withdrawal: Patients
withdrawn from opiates with methadone complain of severe insomnia.
The standard procedure is to ndoinistsr oothyprylou (Rolodex) and
this is generally acceptable. we would suggest the direct comoariscn
of mothyptylon and GP 41299 in a random sequoncs, for 3~S nights.
Acceptance by this population would icdiccts s high dcgrcc of soporific

activity.

would be pleased to undertskc any of those studies, with
study as the most profitable for you «w the study that may
add materially to your analysis of this novel compound. May I suggest
that you call my office and visit with on on December 10-12, December 16
or December 23. Unfortunstcly, I will be out of my office at the other
timss in the next tow weeks.

the

We

EEG

�u
"Jaw-'34”

Vrvw'

"r

m‘-g—-,-‘-.

«wmwamxmw—v-

Kaichar, Gutsy

'7

Thank you

..-

w

,-.

information.

November 29, 1968

for the opportunity of tevicwing this interesting

N—'r"mp~a-'..d

Sincarely yours,

“ﬂit-3’1

www—w-

s
""25:

r."

ea)"

Fink, M.D.
Frofeusor af Psyehiatty

Max

v
v.»

-

mil

In ch¢ sweat that an EEG study is of intﬂtiﬂt, I would also
recannnnd that parallal atudiau be undertaken ta determine the
affects of GP 41299 on the 'alaap«print' -« the eomputer analysis
of the allwnight sleep E36. Tia techniquas available in this
country provide more quantitative information than reflected in the
summary from Dr. Carma, ané allow a more definitiva claauificgcion
of I ate compound and its coapnrison with established alaepvproducing
agonca in quantitativn terms.
P.8.

-

v

up"

m"

"w

~

w-

~—

r;

rrw—Ivz-wm'r-w—v

«

V...

F";

«-

SW'WFMF"

J

.sv—n

Km”

mnwrmﬂwrmwawwv

vwmqmvmnwﬂl"

"Ha

�</text>
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              <elementText elementTextId="36493">
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                    <text>»

“urn-«r

x-

r

November 29, 1968

uma-w-vmx—w-wwwwa

mm»

'"v'grwamr-mnw

Mr. Alden Bober

Acting Chief Chemist
U. 5. Customs Lab.
103 S. Gay

Street

Baltimore, Maryland 21202
Dear Mr. Bober:

Attached are three samples, individually labeled, of

presumed marijuana substances. lVo of these are now under
study and we request an analysis to provide definitive
reference data. The third is a sample delivered to our
Department by a substance user and an analysis, if available,
would be useful in helping us deal with other similar users.
The sample

of

THC

was

received from

NIH

(Dr. Efren).

The sample of marijuana was received from
(Dr. Scigliano).

Thank you very much

NIMH

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Novombor 28, 1968

Door Joyce,

plooocd to talk with you and I look forward to
Gracia
Sonata Bospito1- tho cite of our convulsive
your visit to
therapy study. on Thursday morning. I would oak that you moot
with my nooociatoo and discuss your :tudy, roviow our records and
stuéy and assist us in tho further develoonont of this program
by amounting thou: questions whioh already have no onowor.

I

won

The

on the main

hospital in at

float.

we

would

Street and our laboratory is
anticipate touting about 9:30 a.m.
620 East 76

I thall try to attond tho Eastotn EEG nesting and we
should bo ablo to make the plans-morn dofinito at that time. In the
event that I cannot coho, I can be rooohcd at 369-7900 or in
the ovoning at 516~666 5A44.
The

physician: involved are

physician and project leader; Dr.
’

and

recently amigrotod

Our

psychologist, Dr.

Jiri

from tho Prague

Dru. Riohntd Abrams. a roaident

Rouhicok. Visiting Profoooot

Psychiatric Institute;

and

Dr. Martins Green. and attending neurologist and long time ocuworkot.

I

on most

Rhea Dornbuoh

grateful for your assistance

to matting with you next weak.
My

will also attend.

Eavo a good

and look forward

flight

I

best regards to Ivor.
Sincerely yours,

Max

Fink, H.D.

�</text>
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                    <text>Roveeber 28, 1968
Dear Joyce,
was pleased to talk with you and I look forward to
your vieit to Gracie Squero Hospital—~ the site of our convulsive
therapy study. on Thursday morning. I would not that you meet
with my associates and discus: your etudy, review our records and
stuuy and easiet us in the further development of this program
by answering those questions which already have no answer.

I

hospital in at 620 East 76 Street and our laboratory is
floor. He would ontioipete meeting about 9:30 e.u.

The

on the main

I shall try to attend the Eastern EEG meeting and no
able to make the plane not. definite at that time. In the

ohould be
ovont that I cannot cone, 1 can be reached at 369~7900 or in
the evening at 516—466 saaa.

physician: involved are Dre. Richard Abrams, a reeideut
and
physician
project leader; Dr. 11:1 Rouhtcek, Visiting Professor
and recently emigrated from the Prague Psychiatric Institute; and
Dr. Martin; Green, and attending neurologist and long time cowworker.
Our psychologist, Dr. Rhee Dornbush will also attend.
The

on moot grateful for your eonietenoe and look forward
to meeting with you next weeke Have a good flight !

I

My

best regards to Ivor.
Sincerely yours,

�</text>
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                    <text>November 23, 1968

Dr] William Tabor

A.H. Robin: 00.

Richmond, Virginia

Dan: 3111,

I look forwuré to meeting you on Hooday, December 2.
3
I will be a: a conference on ﬁatropolitan Hospital at 10‘. 00 «.m.
and will be back at my oﬁfioo at 5 East 162 Street by 11:30. Consider~
ing your appointment at 2: 45 can VD meat at noon and try to be through
~

by 2:15 p.m.

?

if that is

at 10:00 a.m.

T

not satisfactory. can

Tho tyhamnte

§

3
E

The

f
g

wo

meet Tunsday morning

protocol for

AHR~1900

'\
\.

Our

wo

can demon~17

have completed our clinical fanfluramine study but have
yet to summarize the data and to complete the cane reoorda.
We

It will be a pleasure to diocusa these projects with you.
Incidentally, both Dr. Simeon and Dr. ﬂashing: were pleased with the
exhibit in Chicago and stimulated us to look forward to another.
Please call

X‘\

has been approved and on1.y requires

laboratory data program is operational and
jatrate the next step as provided Dr. Itil last week.
f

x\

laboratory data and toport are both completodL

your aoquioaconca.

V.

"

my

office to confirm the date.
Sineeroly yours,
Max

Fink,

M. D.

�</text>
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...&lt;»

November

l9, l968

Mr. Carlos M. Rios

at Large. Manhattan
3l4 East l05th Street
New York, New York l0029
Councilman

Dear Mr. Rios:
Thank you very much

our program.

for referring

Mr. Luis Collazo

to

—.

.7

vmwwtw.

—.-

"(——

that he be admitted under commitment
procedures is not feasible since our only program is for
the treatment of opiate dependence on a voluntary basis.
In addition. patients who apply and who are under jeooardy
of imprisonment are usually unable to participate in our
Your request

treatment program since our program requires the long
term continued maintenance on narcotic antagonists.
A

member

of

my

staff indicated the various locations

In the event that these measures
have arranged for him to be
are not acceptable to him,
seen at the next available screening date.

for

immediate commitment.

we

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

l9. l968

Mr. Carlos

M. Rios
Councilman at Large, Manhattan
3l4 East lOSth Street
New York. New York 10029

Dear Mr. Rios:
Thank you very much

our program.

for referring

Mr. Luis Collazo

to

that he be admitted under commitment
since our only program is for
feasible
procedures is not
the treatment of Opiate dependence on a voluntary basis.
In addition. patients who apply and who are under jeopardy
of imprisonment are usually unable to participate in our
Your request

treatment program since our program requires the long
term continued maintenance on narcotic antagonists.
A

member

of

my

staff indicated the

variOus locations

In the event that these measures
for
have arranged for him to be
we
are not acceptable to him.

immediate commitment.

seen

at the next available screening date.
Thank you for your interest.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Hszp

�</text>
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                    <text>November

l8. l968

Hr. A. Mahmood
Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmoud:

Enclosed are two capies of our report "Psychoactive

Drugs and the Alert EEG"
Medical Review.

to

for publication in the Pakistan

its

publication and would appreciate
receiving a capy of the Review as well as the reprints you
‘suggested.
I look forward

Sincerely yours.
Fink. ".0.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>Septembea 1, 1968
Ma. A. Mahmood

Phhiotan Medical Reuimm
Kamchi, Pakistan

Dena Mn. Mahmood,'
Thank you 60&amp; you&amp; bind

in the special edition

the Pahiaxan Medicot Reuiwm.
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in pamtécépation In thio vozume; in add£t£on to the Eiot 05

inuﬁtad conznlhuzoaa.

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thd £nvi£at£on.
ﬂincemezy gonad,

Fink, H.D.
Pwoﬁeoooa 05 Paychzatng

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                    <text>r-«ar-x—rwm

an.

“an“:

uhmwzwmm-vvw’ﬂ'ﬁuﬁtwﬂ'r a -w-Iva~.‘:".w

.4

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A
A

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Wk-w

"WW—«mwmvm—w

November 18. 1968

Br.

A. Mahmood

Managing Editor
The Pakistan Medical Review
505 Quamar House, Bunder Road

Karachi. Pakistan

Dear Mr. Mahmood:

Enclosed are two copies of our report "Psychoactive

Drugs and the

Alert

EEG“

Medical Random.

I look forward

receiving a copy of
suggested.

to

for publication in the Pakistan

its

publication and would appreciate
Review
the
as well as the reprints you
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

‘7'?er

«ar “—3-:

..-.-~»

“Mm-{w-‘n'nwt

.

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_

November 12. l968

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New

York

Gentlemen:

Enclosed is a capy of our report “High Dose Chlordiazepoxide
Therapy of Anxiety“ for your consideration for publication in
-Quanta: Thenapcutic Reseaach.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="102763">
                    <text>November

Dr. Stanley Yolles
Uirector
Rational Institute of Mental Health

5454 Wisconsin
Chevy Chase, Maryland

Dear Dr. Yolles:

writing to ask your assistance in legally making
available supplies of marijuana for experimental research.
I am

w.
.-

van-W’s:

mp-

.

s,
‘

“"

m-mmm-

-

‘gzeuts—swfn'ﬁﬁvw

any.”

I

.'
"1-:

wvnw—star-‘mycmv

‘Zwrm

renew

‘ﬁ-vl'ﬂ

any»:

17rrmw.:¢

‘;
.13

(Iv-mu

I
3-;

AM—

Qua—r

.

l2 , l968

invited to a meeting at the national
Institute of mental Health at which studies of marijuana and
cannabinols were discussed. Following that meeting I obtained
the necessary certificates, filed various forms, protocols
In May, l967 I was

applications to hlhh, appealed to the Federal Bureau of
Narcotics and attempted to obtain supplies of marijuana through
legal channels.

and

Through the cooperation of ﬁrs. Efron and Levine of the
Psychooharmacology Research Branch. 50 ampules of THC, 10 mg
each. were made available this summer. Since an essential question
to be answered was the comparison of the effects of marijuana and
this THC product. I deferred the studies of THC. awaiting a response
from the appropriate committees at NIH. I answered the requests of
Dr. Scigiliano and filed the appropriate forms. In late August I
received a detailed inquiry from his committee. which I immediately
answered. I have not heard from that connnttee since August 23.
I deferred undertaking the studies of THC, hoping that the Committees
in Washington would respond in some direct fashion - either denying
my request, or providing me with some answer which was reasonable.
I have not heard from them and on frequent occasions I have called
and received no reply.

Recently,

to requests from your
Dr. Freedman whether our programs were under
way. At Dr. Freedman's urging, we began our studies of tetrahydrocannibanol on November l. Unfortunately, the supply of
THC is severely limited, since six of the
fifty ampules arrived
in a damaged condition, leaving us with 440 mg as our total supply.
Mr. Kavanaugh. responding

office. inquired of

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November 12, l968

«.3

for

Having no response from the Committee
some months, I would be grateful for a

from your

office or that

Committee.

or Dr. Scigiliano
forthright reply

In the event that supplies of marijuana for research are
not available from the National Institutes of Mental Health
(and having been told by the Federal Bureau of Narcotics that
Health that
it is only through the National Institute of Mental
legal supplies can be obtained) can you advise me as to an
alternate route, within the law, that would allow us to continue
this research program?
am

So far, I have hesitated to write to your office, but
encouraged to do so by your assurances in June and your

recent assurance to Professor Freedman that we may turn to
situation no longer appears tenable.

you when the

Thank you.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
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                    <text>2

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November 12. 1968

Current Therapeutic Research
520

New

Fifth

York,

Avenue
New

York

Gentiemen:

Enclosed is a copy of our report “High Dose Chioroiazepoxide
Therapy of Anxiety“ for your consideration for publication in

Contact Themmuuc

Rum.

'

Sincereiy yours.

1:;

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Fink, M.D.
Professor of Psychiatry

Max

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                    <text>November

ll,

1968

Br. Stanley Yolles

Director

National Institutes of Mental health
5454 Wisconsin
Chevy Chase, Maryland
hour Stan,

Separately, I have written regarding the difficulty
have had in obtaining supplies of marijuana through legal
channels for research purposes. The climate which encourages
this complex bureaucratic limitation of studies in this
important public health prohlom encourages no to write
regarding an important associated problem.

we

During the past two days Dr. Paul Kielholz has lectured
New York Medical College on the subjects of narcotic
the
at
addiction and the treatment of depression. In the course of
our conversations. he shared with us recent roconnnnoations
of the special committee of the World health Organization,
of which he is a member.
-

u
.

.
..

m

k‘g?’xlllf‘;'"ld"v‘9

The

Conmittoe's formulation, as distributed by him,

is attached. indicates that cannabis has
application and that it is to be classed among

a copy of which

no medical

the habituating compounds.

inquired the evidence upon which these two decisions
Dr.
Kielholz referred me to the well known literature
based.
were
of the past centuries. He made it clear that the Committee had
acted without additional significant evidence - surely, none
that he could refer no to in the scientific literature.
When I

..

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swamp-3m.

or

v

:

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9"!"er

Considering the difficulties which already enshroud research
in marijuana and the cannabinols. such a pronouncement, especially
if accepted by the United States representatives. would ensure a
most difficult future for research.

�.r,

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wry.“

Dr. Yolles

November

—2-

ll,

1968

‘W-WW'rwl-Ivﬂvv

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mum].

raw"

I am taking the liberty of bringing this to your attention,
in the hope that you can refer this information to the appropriate
committees of your organization, and perhaps the leading psychiatric
associations of our nation, so that this proﬁlem can be avoided.
I am sufficiently discouraged, to send copies of this letter to
the appropriate agencies myself, realizing. however, that such
a communication without the political support of offices such as
yours. will have little impact.

Thank you for any actions which may assist in relieving
this potentially serious interference with research in an

important public health problem.
My

best personal regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>'\

-,-»

'V'v-sr- ~.-«mwm

a:

‘

wa—nu-rmv-mr'

“-1

tmt‘vtm'n’us; “1': w- wvmnmmmuwwwwwmv-rw

‘m'

,‘w. mm»

"pr: «gnaw-amp.“Why-“10‘.

,

~7..w:‘.~lrxr1r“ WIN-run"

Novembce 8, 1968

0e. Phizip

A.

Boyce,

Je.

Medical ainectae
Menéon Laboeatoniee, Inc.
10236 Bunkee Ridge Road

Kama Cay,

Meow 64137

Venn 0e. Boyce:

Thank you 60a yuan tattea 06 Novembea 4, concenning
pyaaualeaone. The bindieb we peopoeed éoe thee compound
weae deacueeedeuéth De. Pogge in 1965, jubt pecan to my
Leaving Micsouni. My ﬁizee contain the tezxeee to De. Pogge
and the paapoeed peatacoz, but not the phaemacatogical an
cliniceﬁ data which he eubmétted. That 5££e wee test en
Miaeauni.

Beger anbwening gone hind Lettea, I woutd appaeciate
05 the avaitabze phanmacozogicat and clinical mateaiai.

a copy

I £00k seaweed in déecueeing the pnopoccd peageam ea
coon ac I have had a chance to nead.the availabze data.
Sincecezy gauze,
Fink, M.v.
Pnoécéean 05 Paychiatey

Max

MF:kp

v

2mm

~:7-

~--»-

,-

we

n

_

2

�</text>
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                    <text>November
T0

won

IT

This

currently

3,

1968

MAY CONCERN:

is to certify that Professor Jiri
empioyed by as as

Roubicek

is

Visiting Research Professor

in the Department of Psychiatry,

New

York Medical

Coliege.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>November

7. 1968

Dr. Pau1 H. B1ach1y

Associate Professor
University of Oregon Medica1 School
3181 S.H. Sam Jackson Park Road
97201

Port1and, Oregon
Dear Pau1 .
As

is typica1 for this time of the year. there are

studies under

many

The naioxone study was begun again and we
have recent1y given as much as 600 mg a day. Protection against
antravenous heroin seems to 1ast, at this dose at least eighteen
way.

ours.

In para11e1 fashion we have continued to expiore the
efficacy of methadone in b1ocking intravenous heroin and find
that at 100 mg per day. the subjects do not obtain a euphoric
response for up to 75 -heroin. at 1east for eighteen hours
after a dose; and for- mg for at 1east 36 hours.
The duration of methadone using this criterion is 1onger
than we anticipated. and we are continuing to exp1ore the
duration and dose response. Neverthe1ess. one of my staff
has proposed a study of acetyi-nethadoi. Hith our present
methods and experience. we shou1d be equipped to assess the
re1ative merit of methadone and acety1~methado1. not only on
the c1inica1 syndrome of addiction. out in the heroin cha11enge
criterion as ue11.

Before progressing with the detai1s of a protoco1. do
think
that suppiies of acetyi-nethado1 may be avai1ab1e
you
and in what re1ative quantity? If the supp1y is very 1imited.
as I think it might be. then we wouid suggest a simp1e heroin
cha11enge study in some subjects in when we have aiready
determined the duration of effect of methadone.
Our present detai1 studies of methadone shouid be comp1eted
by the end of the year and we cou1d undertake a comparison
study in January or ear1y February. Is
realistic for us

to continue this expioration?

supp1ies are indeed 1imited to ask
supp1ies avai1al1e?
My

it
be worthwhi1e if
it
NIMH
make

Hou1d

to

the
additiona1

best regards.
Sincere1y yours.

Fink, M.0.
Professor of Psychiatry
Max

,
w

NF:kp

�</text>
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                    <text>‘3'.

K’Wﬂ‘rvﬁv'v

7"“

zrlw'nf'mmvmmm—menmw

w a

WWW

a“

-=

-

mi-

muwwwwm&gt; saw-m- Vl'mmumisrnmvww

‘K’E’mf:T’WF'W'VJYI'1'5‘7‘WS-WYW‘"‘.'¢W 'A—wﬁ'. "v- n~»y~m—aw.wm.m

November

mum-

-

v-w-r.‘

4‘

'-

- m-v.

,

=»

m

a

--

...,

»

..

w --

7, l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l81 s.w. Sam Jackson Park Road
Portland, Oregon 97201
Dear Paul,
As is typical for this time of the year, there are many
studies under way. The naloxone study was begun again and we
have recently given as much as 600 mg a day. Protection against
intravenous heroin seems to last, at this dose at least eighteen

hours.

we have continued to explore the
methadone
in
of
blocking intravenous heroin and find
efficacy
that at lOO mg per day, the subjects do not obtain a euphoric
response for up to 75 mg heroin. at least for eighteen hours
after a dose; and ford‘bm’g for at least 36 hours.

In parallel fashion

duration of methadone using this criterion is longer
anticipated, and we are continuing to explore the
duration and dose response. Nevertheless. one of my staff
has preposed a study of acetyl-methadol. With our present
methods and experience. we should be equipped to assess the
relative merit of methadone and acetyl—methadol, not only on
the clinical syndrome of addiction, but in the heroin challenge
than

The

we

criterion as well.

Before progressing with the details of a protocol, do
think
that supplies of acetyl-methadol may be available
you
and in what relative quantity? If the supply is very limited,
as I think it might be, then we would suggest a simple heroin
challenge study in some subjects in whom we have already
determined the duration of effect of methadone.
Our present detail studies of methadone should be completed
by the end of the year and we could undertake a comparison
realistic for us
study in January or early February. Is
Would
be
worthwhile
to continue this exploration?
if the
it

it

supplies are indeed limited to ask
supplies available?

NIMH

to

make

additional

.ve'x

My

www-

best regards.

uni-re

Sincerely yours,
mmavww

Fink, “.0.
Professor of Psychiatry

Max
"-a',

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Mszp

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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the health Sciences
Los Angeles.

Dear

Califbrnia

90024

Phil.

I want to thank you for your consideration in sending
a copy of the volume “Treatment of Schizophrenia", which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways, I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations

on a study well done

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp
'

r
M"

c’m‘

ermwvc:mtmw"rmwrv

?
,«g,

E's‘.fwx’.

r."

n»:

7—

�</text>
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                    <text>murmur-m

November

7.

1968

Office of Information
Nationai Institute of Heaith
Bethesda, Haryiand 20014
Gentiemen:

appreciate receiving a cony of.“NIH Almanac 1968!.
an information bookie: on the National Institutes of Health, as
described in a recent issue of Science.
He

would

Thank you.

Sincerely yours.
Fink. H.D.
Professor of Psychiatry

Hex

�</text>
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                    <text>November

Dr.

Philip

7,

1968

R. A. May

Clinical Director
The Neuropsychiatric Institute
UCLA Center for the Health Sciences
Los Angeles.

Dear

California

90024

Phil,

I want to thank you for your consideration in sending
a copy of the volume “Treatment of SchizOphrenia“, which
I read with care and a great deal of interest. As Jonathan
Cole said in the summary, the study will probably never be

me

repeated because the conclusions clearly indicate the superiority
of biological treatment methods over milieu and psychotherapy.
In some ways. I regret that such a study had to be undertaken,
for the data which is so convincingly presented here. was well
known soon after the phenothiazine became available.
Please accept

and well completed.
My

my

congratulations on a study well done

best regards.
Sincerely yours.
Fink. ”.0.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�</text>
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  <item itemId="3671" public="1" featured="0">
    <fileContainer>
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        <authentication>76a7c65c506b5da49851a8938388ca44</authentication>
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                  <elementText elementTextId="102774">
                    <text>.

mvmW-m

'w'n-v'H'v-w‘u-I-I

November

4, l978

my.”

rm

Dear Dr. Lehr.

,«
..

"v

Wm

v—v—a—u

V;'Wm"‘

-

Wwvv‘Wi

believe the next steps in regard to the prepriety of obtaining
support for research from the Central Intelligence Agency is to request
Dr. Hasserman to withdraw this application. Failing that, it is advisable
to obtain the opinion of the Faculty Senate.
I

-

write-4"»

r'r‘pw-WT—v

funds.

3. Regardless of the financial needs of the investigator. the
Chairman of the Department of Pediatrics exercised poor Judgment in
insisting upon an immediate recommendation. By not allowing the usual
processes of decision to take place, he precipitated an issue which is
divisive. The same results probably face the College as soon as the
public (i.e.. the Faculty, the students. and the community at large)
become aware of such a request. whether or not
is funded.

it

.

For these reasons. I recommend that the whole faculty have an
opportunity to participate in the Judgment, thereby accepting responsibility
for the conflicts that may ensue. The approved motion and the sense of the
discussion may be sent to the Dean with a request that the problem be
placed on the agenda of the next meeting of the Senate.

a

.r-arvv

“Fm"n-ﬁlv'r

~

sees this issue as a sensitive one, and
appears evenly divided as to the prepriety of the College accepting such
The Research Committee

2. The Chairman of the Department of Pediatrics acted as if the
issue was a sensitive one and obtained prior permission from the Trustees.
the President and the Dean - steps that are unusual.

r”-

&lt;

l.

Incidentally.

I

regret that

Dr. Nasserman and Dr. Freedman were

allowed to participate in the Committee's discussions. Because the
Chairman of the Department of Pediatrics exhibited an insensitivity to
this issue it may be advisable for the Chairman of the Research Committee
to share the Committee's discussion with Dr. Hainstein, who, I fear, may
be under misapprehensions regarding the basis for the decision of the
Committee (notably. his awareness that some members of the Psychiatry
and Neurology Departments do not share his scientific views). It would
be regretted if Dr. Nasserman's misjudgment of motives were to color
his reports to Dr. Neinstein, and that the Research Committee be considered
as infringing on Dr. Heinstein's academic freedoms.
Many

thanks; and

I

trust these

comments

are helpful.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

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                    <text>October 29. 1968
Dr. Alain Sanseigne
Squibb International

909 Third Avenue
New York. hen York l0022
Dear Alain.

N,

”m,

“Hymn,

Enclosed are the individual case summaries for each
of the patients in the fluphenezine decanoate - fluphenezine
enanthate crossover study. More complete case records are
available in our files and will be supplied if you wish.
These summaries indicate the essential nature of the changes
accompanying the treatment and provide the backround for

our report which

..

we

submitted

earlier.

\wq

I

”New

trust these are helpful.

,.

Sincerely yours.

4;
i.

um,

«

a~

4‘:r

Fink. M.D.
Professor of Psychiatry

Max

w

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4v-

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                    <text>February 28, 1969
Dr. Jack Mnndelaohn

ﬁational Institute of Mental Eealth
Chevy Chhsn, Maryland

Dear Jauk,

After our fine lunch in Ghiradolli Square, and the
discussion of alcohol antagonists, I was pleased ti find the anclosed
in the evening paper, th¢ Oakland Tribung.
‘

we

If theta is anything to this approach or the

it.
Wiesbaden

could look into

Kuuehnau of

My

Do

1

compound,
you have the data of the mathods of Dr.

has: regards.
Sincurely yours,

Max

Fink, M.D.

Professor of Psychiatry
mf

�</text>
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                    <text>r
.

n...

yaw-.7

-

-—.vv.

yr’r—Mvv'nn

v

w,»

-

‘wqumr

rubrunry 25. 1969

wilhol-lun Iﬂlwlch
Chair-an. Cal-lttoo an Award.
duality of Biological Psychiatry
Galcsbnr; Btato Randarch Hotpltal
Dr.

Gal-nburg.

Illinois

SlAOl

Boar Ullhcl-dnd.

It xiv-u both A1 Prouduna and nvuclt grout plnnnarn co
nub-1t the cacloood rlporz ontttlad, "8.: Ratios of marketain Puorpcral Schisoyhrtnll - A rhyslologlcal Interaction

Bctvudn Hothnr and Fauna“ by Dru. Hichnnl Tuylor and Robert
Lariat, to: tho consldordtloa of the Connlttou on Award: for
the A. E. Itasctt award.
Dru. Taylor and Lavina are in

.
—.

v

training at our Ccllcgo. During

thcy undcrtook ludapdnd-at rosadrdh

Amwnvv’m

lath

-mwmn—a,wmrﬁv

E

1n paychopharuncology,

Al and

I

found tho rnport

at special lnrorurt. for if

furthcr :tndlad vurify tho nuggodtlonr undo, than thay provide
important cvldcnco for the blolealcnl ucchaalruo of schizophrcnln

and Inturnal—fotnl
Uh

4

projcct:

also
his. to collabordeu in the vcrltlcactoa of an
lutnroctln; rtport by aboard: lﬁwil; relating Id: of offspring
to maternal paychouiu. Finding that the local data did indeed
conflrl that ruporc. they sought ottcctn in the pout~partun
parted: and in davuloplu; soup 331-11 :05: trialu. 1h. lattor
urn umduruuy and thc data too prollnlnnry to ha in this actuary.
found

and
“-1va

that: third ycar of rtnldcacy
that: olccttvu crnlnlng period.

con-and

on Awards.

incarnationu.

this rcport to tho condtdoraclon at the

ﬂat bar: ragardr.
Sinecrnly yours.
Ha: Flak. H.B.

Professor of Psychiatry

Mlzkp

cc: A. H. Pracd-da. H.D.

Committed

�</text>
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