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                    <text>mam—:7

7333-83183
20 December 1973

Barrett Scoville,

M.D.

Division of Neuropharmacology
Food and Drug Administration
5600

Fisher's

Lane

Rockville, Maryland 20852

“um-”w.

vw-rvw»wv'w‘&lt;v€"“"

v
~/-‘

v

Dear Barry:

I am enclosing a copy of a letter which I sent Al Gardner
in July. In that letter, I was proposing to discuss the use
of quantitative electrophysiology to assay the bioavailability
of CNS—active drugs.
I think the methods are now sufficiently developed, both
in the quantification of EEG and the statistical processing of
EEG and behavioral data, to allow more extensive correlations
of data collected to assess such questions as the rate at which
a drug affects the brain, and comparisons of different dosages
and probably different fbrmulations for rate and degree of ef~
feet.
I

enclosing a preprint of a report which summarizes
our experience to December, 1972; and a reprint published in
1971 on statistical methods used to analyze rate effects with
intrawenous pehtothal.
am

Should the Division of Neuropharmacology wish to assess
these methods, I would be pleased for an opportunity to dis—
cuss the experiences and the potentialities in detail.

It

was fun

flying with you.

and healthy i97h.

My

best wishes for a

happy

r‘,-n-.n:

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.mvwmwﬁm‘mtﬂ?

MF/cis

Encls.

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                    <text>73AP-828AP
20 Doccmbor 1973

Jonathan 0. Cole, H.D.

Temple University

Phlladolphia, Ponnoylvania 19122
Door Jon:
At the ACE? matting

1t ocomod important to provide an apportunlty to respond to the proposed policy concerning resonrch
in man. I have sent the oncloood letter on behalf of the APPA.
that

you must ho involved with the formulation of
if would be possible for you to
present a proposed roopoooo on behalf of the APPA at the Council
wanting in March. I would be pleasud to work with you on this
and to out said. the tins beforo Council at your convonioooo.

tho

Knowing

ASH?

my

response, I wonder

it

best regards,
Sincerely yours,
Max

MF/cls

Incl.

Fink, M.D.

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                    <text>7453-07283
12

rahruary 197k

M E HVO R

A.N

To:

Wilton w.-Shroava, M.D., Ph.D.
Acting Associate Chief of Staff for Raunarah

D U H

VAR-Hoxthpor:

Fink. M;D.
Protaaaor of Psychiatry

From:

Max

subjact: Propoual of Dru.

Sn and Boson, "Molecular Modal

of Morphina Dopandanca"

Ra:

632/151. 2/1/74

is a basic acianaa investigation of hypotheses
of abronic opiate use.
tho
pathophyaiolosy
eonaarning
The study

Dru. Sn and Boson propoaa to no: tho oholinargie aspacta
of the nouronnscular junction of rat diaphragm to stamina the
oignifiaanca of acatylcholinc inoraaaa in dependence and ab~
atinanaa. The study in wall daaignad. tho nathoda are faaaihla,
and tho authors hart axparicnca in using these nathods.

prison: version of the yroyoaal is very much improved,
with an axonllont rationale and a more detailod praaontation
The

of methods.

Tho study does not involve human

subjects.

The authors toquaat tho VA to outablish the laboratory and
request no funds for pataonanl and only limited ouﬁpiina during*
aha firat your. Thu oaoond~yaat augment in modaat, consisting
half in aquipuont and half in taohniaian support and supplies.

Racoamaggation:

If ch.

VA

in ahla to provida basic science

laboratory aquipnant for a nonrpatianc~oara effort through itsand
establiohad grant machaniama, than tho hodgat is appropriate

relevant. avan mode-t.
Approval
MF/cia

is

reconnaodad in the amounts raquaatad.

�</text>
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7

'

Jennery 1974

Alan Henley, M.D.
Mbdicel Consultant
Center for Studies of

Narcotic and Drug Abuse
National Institute of Mental Health
5600

Ftaher'e

Lane

Rockville, Maryland 20852
Re:

HSM

62-73—260

Deer Alan:

During the past two months we have become ewere that a nua~
methadone heve begun to request detoxifinow

her of patients

cation.

u suitable candidates {at neltrexone.

Thane men are

we

have three such candidate. for
I have delayed induction
to cycleeocine~1n the hope that neltrexone would soon he eveileble.

now

date

I

whom

grateful if you eould indicate the approximate
supplies of neltrexone will be eViilehle to this unit.

would be

when

Sincerely yours,
Fink, M.D.
Profeeeor of Psychiatry

Mex

MF/cis

�</text>
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                    <text>21 March 1974

“.30
Wt.
mm
km:
Bayville, in for}:
3&amp;3
11

11709

Boar John:

I uhumd the EEG “:91: shown to an by my staff.- 911119
the frcqmuies an irragnlar and the voltages variab 1e, I an
not an anything thick, by itself. would ha considered patho—
logical. If ch: “:23“: 1| umtmtic, I would so no forth”.
than ha nhauld be can: to an ”‘If an sum-at 1: amt-matte,
propriate adieu).
ﬂy

but

”non.

raga-ch.
Sincerely yours ,
Eh:

Mg Mon.

Profauor cf Psychiatry
I!!! at:

�</text>
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                    <text>June

5a

1975

Gerald L. Klerman, M.D.
Harvard medical School
Boston, Massachusetts 0211b
Dear

I

was

Gem.

I. too,

enjoyed the session on Depression and although
enxious
about the materiel before the session, I was
quite

pleased with the result. l have received many favorable comments
from ley as well as professional friends ebout the ECT presentation.

is the present draft of the report

you requested.
some
the
excuse
so
for
publication,
are still re~writing
paper
of the typographical errors and ambiguities.

we

Enclosed

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of PBychistry

Max

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                    <text>February 3. 1970
Dr. Gerry Klarnan
50 Alston Avanue
New Haven, Ibnnocticnt
Dan: Gerry,
Tue waeks agc I had the uncond matting with editars of
Planum Publishing~~ first with My. Uball and than ﬁr. Weingnrten *w
who discusuad the foasibility and negd for an ad&amp;itiona1 journal
davoted to drugs and behavior or drugs and btain function.
I hulieva

that there is naed far such a journal, particularly if it is dedicatad
to studies in man. Mr. Whingnrten revicwad a list of our co~workera
and friands with wham he had spoken, and I ahareé with him some of
my views cf the mark they had dune.

It ans apparant that he was favcrubly inclinad to the
support of thin vanture which yen had axvralnad. and I encournged
him to continue to elicit your support. Thu mattings next wank at
the ﬂaw York Eilton may provide the oppnrtunity for a revicw of this
suggestion, and I hope that yau will provide the guidance which

ha

may

require.
My

be arrangeé.

been ragarda. and I do hope that something can

Sincerely your».
33: Fink, M.ﬂ.

�</text>
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                    <text>"-

‘“

"9‘

"

x

-"-v-

'

"i” '6'“)

»\'-.r.«-

«ﬂu-«m»

saw—aw

mummww—w‘wo "ﬂ“.

-7“—

my—

Fabrunry

3.

1970

Dr. Gerry Klernnn
50 Alston Avenue
New Raven, connecticut
Dear Gerry,
Tua wegks ago I had the aecoad meeting with editors of
Plenum ?ub113h1ng~~ first with Mr. Uball and than ﬁr. Weingarten *«
who discussed the feasibility and need for an ndéitional journal
I believe
devoted to drugs and behavior or drugs and brain function.
dedicated
in
if
such
it
15
a
need
particularly
for
journal,
that there

to studies in man. Mr. waingnrten reviewed a list of our cauworkara
friends with whom he had apnken, and I sharad with him some of
of the work they had éone.
views
my
and

was favorably inclined to the
It was apparent that hehad
which
expressed, and I encourageﬂ
venture
you
of
thia
support
him to continua to alicit your support. Tha meetings next week at
the new York Hilton may provide the opportunity for a review of this
suggestion, and I hopa that yen will provide the guidance which

he

may

Inquire.
My

be drrnngad.

has: regards.

and I do hogs

that something can
Sincerely yours,
Max

.,,,

_..r,.,.

m

nvr

“7",...“

army.--

~
.

'mbuW-DVWW-

Pink, 3.9.

�</text>
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                    <text>Decmber 30, 1966
Dr. C. James Klett, Chief
Central NP Research laboratory (1513)
‘

mismtion

Veterans
ibspital
Perry Point, Heryland 21902

DearDr.Klett:

Thankymverymzchfortheanmumntoftln

lethAnmanAConfemnoe. Eitrnrlormeofmy
associates will be pleased to participate in tide

Wendlmuldbegmtefulfwenadvamedoopy
of the

mwhenitieavailable.
Mybast regards forth New Year.

Sincerely yours,
Mag

rink,

v.13.

Profesaw of Psychiatry
MF:kp

‘

�</text>
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                    <text>tebruary 8,
C. James

1965

Klatt, Ph.D.

veterans Administration aoapttul
Perry Point. Mary!“ 21902
Bear 92. Exact:

:

would bu plansad to send
uapresnntativa from thesa
Annual
Conferenee
of VA Cooperattvt
Tcneh
laboratories to the
Studios in Psychiatry. "bald you plan-c :trangu to sand I: a
e091 9! tbs prograu an team as 1: 1: astablishcd?
9%

Riccntly, I had ch: o¢¢gsian to can a copy of on. of tha
:uport. issuad frcn thn Cuntrnl I! Innunxch Laboratory at Parry
taint. It was Hunter 59. datad Hay. 1964. by Banistald and hi:
co~worknrn. In £t pouuthln 102 II to roettvt a copy of thin :0“
port. uni a list a! athcr ruportl cut: any ha publienlly availabla.
so that II any cannot: than. that at. :nltvunt to studidl in this
laboratocy?
Many

thanks for run: aoopcraeion.

Sinucrcly youri.

H133:

Hi: link. H.D.
Protester of Puydhtatry

�</text>
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                    <text>.,

s

.

«n-

.
.1
~

-

n

'rw'ex‘r

a-Iv

mung-y

nu»

v.
.r‘

w
u
-

g

F

;

~

E

December 19, 1969
Dr. C. James Klett

Chief, Central NP Research Laboratory (151E)
VA Hospital
Perry Point, Maryland 21902
Dear Jim,
Thank you very much for the invitation to participate
in the Fifteenth Annual Conference in Houston in April 1970.
There are two aspects of our study programs that may be of
interest to the participants and abstracts are included for

your consideration.
My

best regards

and

best wishes for the

New

Year!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF

:kp

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                    <text>July 17.

1973

Costa Stefunil, 14.1).
of Pays-hum
"‘
mitten Kospital

Went

Athena, Graeme
Dear

Cantu,

halo-ad are three chock: following your request:
l1366 0.3. for salaries
$ 11,200.00
(1390)
#36? 0.8. Ianoct feet
~

,

11368

0.8.

mph”
oops-mutton
I

(600)
to 6/30

1,990.00
2,500.00

Lino: directly the sun at
81.690. representing the salary dune him; and sent Costco Kira:
“minimum his animating um! laboratory expenses to
$1.636.
ISO 73.
.

have ulna paid Dr.

mm

mm
unspent to Donahu- 31, 1973. You will note ms I
ruin
have What some of your requests to arbitrary catngorios, to
as can of theandcontrast allocations. Plan new that m categoricall the
ﬂuiblo.
any cam” (mm
m
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which an
the mount:
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I m melanin; an

“1,380

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wanted) .

m.mm1ammwd.nommtmmunw
m1 three am km in stony Brook; ha ha
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mum. I have mum 300
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�</text>
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                    <text>_H.

A.

,

.VVWTWN...

.A.

..
A

.viv'rr-Mn—Av

-.

.

.wwmqup—gyw-xww

-»-

7383-79483
28 Novembor 1973

Robert 3. Robinson. M.D.

Houropharmaoology Suction
A. 1!. Robin: Company

1407-Cumoinsn Drive
Richmond, Virginia 23220
Dear Dr. Robinson:

I havo just rotnrnod from a trip to Europe and boon tovieuod your lotto: regarding tho EKG chanson associatod with
lonporono (Aan2277). I do not know how to interprot the
data prooontod banana. we have bocono ocouotonnd to finding
ouch EKG changes with many of tho anti-psychotic compounds.

your: ago Dr. Itil and I become oonoernod with this quoo~
tion and in a oyotonotic study o‘ thioridnsinn and chlordinso—
potion oolloctod the out. carefully and had then ovaluntod by
two interniuto. Wu worn inpronand that the EEG ohongos induced
by thioridanino wore significantly groator than those induced
by chlozdiaxopoxido. In a oooond study. patients receiving
fluphonozino. thiothixono. and haloporidol wore examined for
EKG offoots.
In this study. the group of patients had favor
EKG changes than the patients who had rocoivod thioridnxino.
Sinco than I have followod the literature carofnlly and note
tho studios of Ban and Lebanon, Gallant. and Simpson. Each
of that: author: has indiontod that tho EKG changoo following
thioridnnino worn much groatot than othor anti-psychotic dross.
Bonn

it

When looperono cons: to Phase III touting,
tight be
odvioablo for you to connider a direct comparison of its cardio»

vascular affects with tbioridasino and one other anti~poyohotio
compound.

with razord to out own work. our doses are much smaller

and we

anticipate

no

direct outdio-vooculnr difficulty. I
this to my attention.

thank you, however, for bringing

-1-

�,WW-‘Yq‘
'7

..

‘

E. E. Robinson. K.D.

28 Havanbnt 1973

*Zw

Rt have continnad our doaa~£1nd1ns studio: and
now
looking with stutter detail at ch. EEG tad behavioralarteffects
of 3 and 6 as domes.
My

bust regards.
Sinaotcly yours,
Max

rink,

H.D.

Professor of rlychiutry

MF/cts

�</text>
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                    <text>wow»

L-r'WJo-

”MA

.n

NW”.

Mﬂv‘uwviw:

W

,

.vnr.1'm

Jmuazy 16 , 1967
Dr. M. Kletzkin
Department of Pharmacology
Wallace Laboratories
Crembmy, New

Jersey

08512

Dear Milt,

for the bibliogaphy on Carisoprcdol. It is
that most of the mlevant data is published in the
New York Academy of Science's volume and I have requested
this from the library.
I have also received from Dr. Sampson a smmary of the
experiences with tybamate. From our discussion in reviewing
this material, I am even more interested in the possibility
of using either compound in the witlﬁrawal period.
Would it be possible for your laboratory to make available
to me a copy of the Academy of Science's volume of 1960 and
Thank you

obvious

also the

1959 review

edited

by

J Miller?
.A

Manythaﬂcs.
Sincerely yours ,

is; Pink,

M.D.

Professor of Psychiatry

Mf‘ﬂq)

�</text>
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                    <text>January 8, 1969
Dr. Milt Kletzkin

Wallace Laboratories
Cranbury, New Jersey
Dear
_,

,
i

A.“

Milt,

Enclosed is a draft copy of our report ”High-Dose
Tybamate Therapy of Heroin Dependence“. It is my understanding
that this is for your personal use and is not for distribution

to others until after

v
4.,

,
.«_

it

appears in the public press.

,—

Hy

best regards for the

New

Year.

("I-vmm'vwr-wgl)

Sincerely yours,
.

gar-w-aur

Max

;~m:'~r-

:m.

.

Fink,

M.D.

Professor of Psychiatry

.-

Mszp

�</text>
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...

.,.....A,,‘.-_._.,,,_

A".-.

.i
.

~......

March 26, 1969

Dr. Milton Kletzkin
Department of Pharmacology

Wallace Laboratories
Cranbury, New Jersey
Dear

Milt.

I want to thank you for the opportunity to visit your
laboratories which are most impressive.
—

A

.,

"wt-r"

V”.

Sunday I met the Chairman of the 1970 CINP program
committee and discussed the interest in a program of animal
EEG models in psychoactive drug evaluation and classification.
The suggestion was well received, and I would like to discuss it
On

with the full committee

on May

6-7.

If you are interested in participating,.would you be able
to review the world scene and recommend scientists from industry
and the academic scene, who may be able to contribute?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>awn...“

ww~

‘f,

.-

,

.

&gt;

”a...“

,

,

.

.

,

7mg.“

v,,.m“,..“mw. rm'nwv‘.‘ 9'!“ 7.2::

D’mﬂ

”ware“..- u

.7

",1W qmv-mw-

"me‘

“ﬂy 3. 197%
Hank van Riezen, M.D.
H.V. Organon
Oss , Holland

Dear Henk,

I have received the extensive documentation for the

report and I thank you. I will get
you a copy before the meetings.

to

it

01—63

next week, and will send

I regret that I felt I had to disturb you at home last
it seemed prudent to report Joyce's concern. I am scheduled
to visit her on Tuesday, bay 7, and I will report fully thereafter.

week, but

The report to the ECDEU will be sufficient for the FDA. I
realize Kastin’s concerns and I have no need or desire to increase
his anxiety. I have sufficient data now.

in your letter of April 17 sent me to a
associates. The best laboratory to assist us in the
analysis of the behavioral data of the 63-91; study is probably
the Biometric Laboratory of George Washington University. This
center was established with government funds and is supported by
a large contract to develop methods for rating behavior and to assist
investigators. The directors are friends, Ronald Bonato, Ph.D. and
William Gw, Ph.D. Before recommending them, I screened two other
units: the VA laboratory at Ferry Point under Dr. James Klett and
the laboratory of John Overall in Texas. I believe the best unit
for our purposes is that of George Washington University. I met with
Bonato and Guy at a meeting in Wshington yesterday and they agreed
to review the data and to offer their advice and support. I also
met with James Klett, who will be able to meet with us, but is
unable to help with the data. Should you wish to send Dr. Stuhlemeyer
to the U.S. , I would be glad to arrange to visit Washington with him.
number

One comment

of

11V

to

it

to come
to Florida, to attend the
the discussions. He could spend some time in Washington thereafter.
He should bring copies of as much of the data as is representative,
with as many of the analyses that have already been done.
Should he wish

come,

ECDEU

would be

helpful for

him

sessions and to hear the level of

”\rdvr —-:-v

�l ,. v._w,_zr......

V

“an.-.

van Riezen

...

'._,-v.m.m..w-

.wn-uw—m-rw. ——.wr—-_—-.-‘

...............

May

«w...»

«awry.

3, l97h

A-“

was». W‘W”mwvvwvvs4m:pi\rv

——-.

“we..- ~Wg-ww7uw

~:

,

A

-- -... “mm—1

'II-hr‘w-m m...“

.....................pg. 2

As for the costs, there is some problem. Officially,
the Biometric Laboratory is not organized to process data fer
industry, but for investigators. They will analyze the data if

it is listed as coming
if you obtain releases

from an investigator (such as nyself); or
from each of the participants. They cannot
charge a fee. Should they assist you (us) in a meaningful way,
id possible for me to reimburse them for their time. I would suggest
that you allow an initial budget of $1,500, with the guidelinethat

it

pay a consulting fee at the rate of $lSO/day. Should their
contribution warrant, I can clear the payments through you in advance.
(Should their contribution be considerably greater, I can suggest
the amount be increased.)

we

As

for the other notes: I will write the GB 9h protocol
will include the collections suggested by Dr. veen.

next week and

series of studies in the neighborhood
schools, in which the teachers refer children with behavior problems
and reading disability. He and his wife have a team examine the
children, evaluate the clinical condition, and then assign the
children to systematic studies according to the diagnosis and
according to their protocols. These involve administration of
placebo, drug, or comparison drug for extended periods; with
psychological test, clinical behavior evaluations, teacher and
parent ratings, etc. at frequent interviews. The program has
developed data on dyslexia, eneuresis, phobia, hyperkinetic
states. Their clinical and psychological data are excellent; their
Donald Klein has a

physiological measures need improvement.

is still in
Israel; has received my letter; but indicates that he will not be
back in London befbre July. He is planning studies to begin next
March/April, and.vill surely write to you this summer.
I

send

met Dr. Marks in Washington yesterday. He

Please excuse the typographic errors, but I decided to
be back in my office until

this off myself because I will not

next Thursday.
My

best regards.

Sincerely yours,
Max

Fink ,

M.

n.

WﬁFuru'xw-I—WW'IEI‘IR—

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                    <text>12

April

197%

ARIK BRISSEHDEN, M. D.

V. A.

MAX

Hospital

'

PINK, M. D.

Treatment of Chronic Schizophrenia with Oral Hypoglycemic Agents

his

I have read the protocol submitted by

co—workers, and would approve the mission.

Dr. Messinger and

There

is a theo«

reticel objection to this study, since ineulin come therapy has
been found to be thoroughly ineffective in the treatment of
schizophrenia. Hypoglycemia may not alter cerebral activity until
levels lower than

achieved fOr extended periods.
For both these reasons, I would assume that the treatment yroposed
is essentially a placebo thereepy with smell additional risk.
30 mg% have been

However, the risks are small, even acknowledging the
caraiovasculer risk assessed by Dr. Fritts. If we acknowledge
that the therapeutic effect of enthusiasm of the observer and
systematic observations may be mobilized for the treatment of some
patients; I do recommend approval of this project because I believe that Dr. Messinger will be stimulated by his enthusiasm and
we can anticipate some discharges from the hoepitel using this
regimen. I would be less sanguine about their finding meaningful

scientific data.

MF:ed

-

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                    <text>July

29 , 1969

Mr. Dmid Kline

Endo Foundation
1000 Stewart Aveme
Garden City, New York 11530

Dear Mr. Kline:

It was kind of you to respond to our request 30 monthly.
are armious to bring othw scientists to New York to lecture
to our students , and this fund will be most useful in omtinuing

We

this

program.

Thank you.

Sincerely yours ,
Fink, H.123.
Professor of Psychiatry

Max

MP:kp

cc: Dr.

R. Jacobson

�</text>
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                    <text>February 26, 1964
Dr. ﬁathan Kline
Director of Research
Rnckland

State Hospital

Orangeburg, ﬂew York
Dear Hat:

It

use

n

plaanurs to read in the

latest tutu. of Hcdieal Tribune

of your work in undtrdovclopad countries. I had not fully
rculined the growth of this program until I spent in evcning
with Heinz, and he described. with a great deal of fealtng, his
interest in your work. I: was my common: than that this efﬁart
was the mast novel. and tha moat commendable. program to banefit
the mantnlly 111 that ha: come from the United Sauces in many.
many years. Congratulationll

that you had establishad a committee, but I should
be planned to contribute an its work in any way that I can.
I did not

knaw

th.se new laboratories. I am responltble far the rantduncy
training program. This it nccrndittd for thruo years, und I
would be pleased tn consider foreign graduates for appaintments
as reoiﬂentn or special fellow: if you think that work with us
would be of any help.
Again. my congratulations and beat wicket for your continued
A:

'

‘uccc. . o

Sincerely yours,
'

raw/3b

an: Fink,
Ditactor

M.D.

�</text>
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                    <text>NW!- 13,

Rookland State Hospital
Orangeburg, New York
Dear Nate:

menlmhmﬂxisevmingmywxghter

told an that male Nate had received a prize! I know
immediately thatthe mm matIMdheardin
Washingtm were indeed true. and I felt pleased for
you. Oongmtulatima on winning what has become one
for scientific m~
of the natim's outstmding
search. For my bf us in 'psychophaxwolow, it is
a great pleasure? to malize that the advances in our'
field during the past decade are considered scientific
achievemts.
Congratulations md I hops that your futm

m

wait is as successful as your past.

Sincerely yams,
Max

Pink.

Director

mf/ls

M.D.

196k

�</text>
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                    <text>February 1, 1965

W

mm mm
Director of

Dr.

*

Miami State Hospital
01mm. Newka
DearNate,

'hrmnItil mdlwmttotakaﬂﬁaoppomityto
splendid hospitality in
m
Tramningwmamebleme,andwenot

thank you for

ton.

Washing-

mlymjoyedﬂwmmthedimer,butﬁze
be fun.
that matings could,

mmtim

afternll,

Motthismmt,wehavetuat~dnoﬂm1gofam—
pleoumtforl’anlliodu. “hammer, havingahom
good imam: in manning the New York State Psychic
atdc Institute will. Ihwe, thwequally good judge-

mtmdukyoutotmtheatate'eleademhip.
Many

Me for a pleasant evening.
'

Sincerely,
Max

HF:jm

Fink,”1.1).

Professor of Paydxiatry

�</text>
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                    <text>Jmuary

10 , 1966

Dr. Nathan Kline

Director of Ransom}:
Rocklmd State Hospital

Drum-bung,
DEAF

New You):

Nate ,

I

to talc: this apportmity to congratulate you
election as Pmsidont of the American College of
Reumpoyclmphmuoology. I know of no one in our discipline
want

on your

mummasaacimﬂat
Wuyouhave.
Immabletoattendthemtingsin
Puerto Rico, so I could not extend my

whohas

andas‘apolitioal

oongmtulatims in

person.
as

Ifthem ismythingthatlmdotomakeyourtenum

pmidant a sums, please don't hesitate to can
My

best wishes for the

New

on me.

Year.

Sincerely yams ,
Max

Pink, H.D.

Professor of Psychiatry

�</text>
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Stanly your-s,
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Professor of Psychiatry

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January 24, 1972

unsw—

,me

Nathan 8. Kline, M.D.

Director of Research

Rockland State Hospital
Orangeburg, New York 10962
Dear Nate,
As you know, I have been most
interested in the development
of narcotic antagonists as a treatment ior opiate
dependence. After many
years of effort, the model has been supported by clinical studies, and
the qualities of an ideal antagonist have been defined. The National
Institute of Mental Healhh, the SAODAP of the White House, NACC
the
State of New York, and the City of New York are all interested inof these
programs. They are making research funds available, and their
support
has much to commend

it.

However, the principal agencies that have the facilities to
produce the necessary formulations, the industrial laboratories,
preoccupied by their prior committments, and some effort should bearemade
to bring the needs of this program to the attention of the formulating
chemists. With this in mind, I would ask that you consider approaching
some of your foundation friends, with the idea
a special award be
established for the production of a successful that
formulation with the

following characteristics:

specific narcotic antagonism, similar to naloxone;
duration on single administration of 90 days, with
antagonism to injected heroin, 25 mg/ch/2 minutes;
tolerated by man ('safety'); and,
without agonistic features.

is the most likely starting substance now at hand, but other
candidates may be l-cyclazocine, diprenorphine (M—SOSO),
other
specific antagonists now under study at Bristol, Geigy, or orother
labs.

Naloxone

A single prize of $50,000
or $100,000 for 36 months, well
publicized and supported by the authority of one of the leading
found~
ations may serve this program handsomely.

I hope you agree, and raise the question at the best levels.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychigggy
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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102M) STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYGIIATRY

August 10, 1972

Nathan S. Kline, M.D.
Research Center
Rockland State HOSpital
Orangeburg, New York 10962
Dear Nate,
Once again, I must agree with you. It would, indeed, be
a most unconstructive expenditure of our funds, for the State of
New York to re-assess the many unsupported claims of ortho—molecular
therapies. The megavitamin approach is so poorly documented, and so
dependent on parallel and concurrent therapies, particularly ECT
and drugs, that the burden of proof should remain on its proponents.
The probability of exploitation by the proponents is indeed
and
I concur in your request to Ben and to Alan, to put the
high,

State's funds to better use.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Miller
CONFIDENTIAL:

Not

for Distribution

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                    <text>January 31, 1967
Dr. Nathan 8. Kline, President
of NewspsychOpl'xamecoloy
Rockland State Hospital
Orangeburg, New York

American College

Deer Nate,

fewnmths, I participated in the defense
ofecrimixmlomvictedofacepitelmime, andhsvebeenfaced
with issues and questions that seem to go beyond the inmsdiate
During the past

instance. The important question is whether the administration
of psychoactive drugs dwing inprismment prior to trial can
alter the evaluation of a psychiatrist so that a prisoner can
appeutobesmmnmuaymtbe; and,‘vmethertheeffects
of these drugs if given just prior to the trial may alter his

.

mamrysothsthisperfomanoeincotmtmaygiveanuntrueeppeerance
and so deprive him of his best defense.

IamwritingtoenlistyourOpixdmas towhether sucha
is proper to bring before the College, especially in
eliciting the opinion of other umber-s as to the general issues
involved. If the questions appear as significant to others as
itappemtome, perhspstmvwritingofareportintheJmmmal
problem

reflecting our opinions

may be 'ofhhelp

For your information,

case record.

‘

I

am

in other similar instances.

enclosing a short

wtline of the

Because ofthe general nature of this. problem,
a copy of this letter to Jonathan.

I

Thank you for your help.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
co:

Dr. Cole

am sending

�</text>
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                    <text>January 10. l968
Dr. Nathan 5. Kline
Recklend State Hospital
Orangeburg, New York

Dear Note.

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmacology at the
New York Medical College on June l4. The seminars are held
at the Metropolitan Heepital (97th Street and First Avenue)
in the conference room on the l5th floor at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss “Psychopharmecology

Research in Private Practice."
We

I

will defray your expenses and there will be an honorarium.
will call you before June 14. Thank you for accepting

our invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 23, l968
Dr. Nathan S. Kline

Director of Research
Rockland State Hospital

Orangeburg,

New York

Dear Hate,
Thank you very much

for the lecture to the residents.

Enclosed is a small honorarium.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>August

l9, l968

Dr. Nathan S. Kline

Director of Research
Rockland State Hoseital

Orangeburg.

New

York

Dear Hate.

It

has taken many years to develop a usable

EEG

predictor

novel psychoactive drugs. The enclosed reports of
cyclazocine as an antidepressant have been submitted for
publication. Knowing of“your interest and enthusiasm for new

for

model

drug evaluations. perhaps these experiences may suggest similar
experiments with other novel compounds.
My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

22, l969

Dr. Nathan 8. Kline
Director of Research
Rockland State Hospital

Orangeburg,

New

York l0962

Deer Nate,
Thank you very much for referring Dr. Andermann
Karl worked with me at Hillside Hospital in i959-60.
I

found his work

reliable

to

me.

and useful insofar as we remained

in the category of descriptive encephalography.

Quantification
required the exercise of additional effort which he apparently,
at that time was unwilling to assert.

the ClNP met in Rome and we missed
The
dominated
sessions
were
by the basic scientists and
you.
at one point when the votes appeared to go consistently against
The Program Committee of

the clinicians (including myself) attempted to assert your
vote in addition to mine, but was turned down by the Chairman.
Part of the problem may have been the opportunity to induct
Alex Karczmar as a coworker in the Committee. The program that
I

finally unfolded is well balanced

and

i

think very good. There

will be a symposium on lithium as this seemed to be a most
important commonly accepted subject.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

�</text>
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                    <text>17“.. -._..

..

.

-,-

v»

:mm

—

_;

--.-- .. ”(ﬁn—nv— "m.

.—.x . Ier-l.’.v’w.n"-)T'e.‘vv'‘-~‘&lt;.~»m...-

~

Inn-my

..

.7.

.,.V.-,,.

,

..

M

.n

.v..

,

w,

_....— 7m».- “my 4.“

,

, .

.

r...

em

-

,

n

December 8, 1969

Dr. Nathan Kline
Rockland State Hospital

Orangeburg,

New

York

Dear Nate,

It was a pleasure to read the typescript from Nepal
describing the experiences of a psychiatrist with the male
natives called "Sandus” natives who are unconventional in
dress and behavior, monastic, and depending on the good will
of society for survival. They also are users of cannabis,
and some of the cannabis rituals are described in detail.
—

The author presents his data - in a small population (less
than 70) collected over 25 years with an obvious, anti-cannabis
bias. Without stating directly, he suggests that withdrawal,
dependence, asceticism and strange patterns of thought are related
to cannabis use.
—

The assessment of the

A

:v
v“!

vmsv-A

RUFF/Nu“!

effects of chronic cannabis use is

It is difficult to picture this author

--..~

our pressing problem.
obtaining reliable data, but the questions that should be answered
may be phrased as follows.
1.

Given the pepulation of Sandus as described, from what

2.

What

cannabis user population is this sample derived? That is, how
many adult males use cannabis new (for how long) or, how many
used cannabis over the period of this sample?

in

is the history of cannabis regulation

Nepal during the past 30-40 years? Sources
data as to potency (user ratings are enough).

cannabis be made available for assay?
3.

artist,

and

availability

of cannabis

Can samples

and any

of local

there other populations, i.e., criminal, mentally ill,
political, known to be cannabis users; with what incidence;
Are

and with what degress of dysfunction -

if

these can be estimated?

�Dr. Nathan Kline

4.
common

-2-

December 8, 1969

Are there any physical or medical characteristics
to cannabis users in Nepal?

is of interest for its local flavor. Before
needs
editing to reduce redundancy; and checking
publication; it
for the proper use of English. The questions raised above may
provide the additional data needed to put this effort into
The document

perspective.
and

my thanks for the opportunity to read these notes,
best wishes for a successful trip.

Again,
my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>November 3, 1969

Dr. Nathan S. Kline
Rockland State Hospital

Orangeburg,

New York 10962

Dear Nate,

If the program at the AER? in February allows, I would
like to present a report of our EEG studies in normal volunteers
co—chalrmen.

in the committee of which you and Dr. Evans are

Two years ago the date with major psychoactive drugs
presented. Since that time I have expanded the method
to assay new psychoactive drugs and I now have some unusually

was

fine date.
”EEG

The

If an opportunity is made available the
Profile Analysis of Psychoectlve Drugs in

authors are
My

Max

Fink,

M.D. and D. M.

title

Shapiro, D.Sc.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MFtkp

should be

Normal Volunteers“.

�</text>
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                    <text>Maren 12, 1970
Dr. Nathan 3. Kline
Rockland State Eospital
Orangaburg, Raw York
Dear Hate,
The

rules of the

ACRP

are probably too

I have already agreed to sponsor one of Dr.

strict, for

Itil's

co~

workers for this year. I think that Br. Schulta should
be a member and will be glad to second his nomination if

I had tnother vote.

Sincerely yours,

Professor of ?sydhiatry
Hszp

�</text>
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                    <text>Downbeat-221m, 1972
Dr. Btruld

chrnan.
Prettisor or Pnyeh111ry

ﬁ:rvnrd utdaonl ﬂannel.

ﬂnuu¢¢huaoﬁtn ﬂannr&amp;l Eosp1tgl,

30‘th .

m. i

own I

Dour‘aorxy,»

_

.‘I an 9101306 to accond 1h. non1ngtion of Dr,
nthXbors tbr*IIIbnruhip 1n the APRA. '-

I

bit: for wort thﬁn A decade, and
rbllavca his rcaaareh efforts in pnrnhothnruny.
and LED v1th arugt 1ntcrcut. For 1 auﬁbor of yoars
he crou$od paaiant: in ca expor1nmntal frcnn 51v1ns
than ctpsulca containing 18». nuphotu-incl. or pluocbo.
Eh. study v1. conglax. bat he carrted it out wall.
ham.

h1vn known

‘

.

K. 1: n town 1nvwnt£gutor and hns Hunk intcrcct
1n‘al1nionl uad cap¢r1nnnttl tupoat: of pnynhiutry.
I in plensod ta roeunuand him tor nunberrh1p.
‘

'

‘

sincerely ynﬁrn.

uh: Fink.

N.D.

Professor of Payehintry

was

an. to Dr. qucph 31!:new

tart $1.1: Puyuh1ntqli-Instituto

�</text>
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                    <text>7%3—612

April 9th. 1973
351mm:

8. Kline. Mm...

Boseurah ﬂenter,
Ruckland State Hospital.
Orangdburg. N.Y. 10962.

Dear Hate,

is ccnvenient.

I
I m guest of the Jansen
family. I found their hospitality macadamia. and.
the occasion is mmble.
I look forward to Joining the comittee 1n

was

Augmt 29th in Beer“

last in

Baez-so,

Became on August

29th.

a.

When

-

Sincerely yours .

m Fink.
Proteuor of Psychiatry
24.13.

EN13

v

HAI‘WKW‘WJB

”/5;

n

�</text>
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                    <text>ml.

gut

wrizgtm"

We

GIVWVK'M“

T"

an

TBSB—SSS

March

5th,

1973

Nathan 8. Elias, M.D.,
Renoarch Canter.
Roeklsnd State Hospital,
Granadburg. R.Y.
Dear Kata.

I would 11k. to he in Mirueillel an the cvuning

of August Slat. I could be in svitscrlnnd
the yrscoding two or three dtya with easy.

on

;ny of

Congr:tu1ctions on you» anniversary celebration.
W

hm 2‘08““.
Sincerely yearn,

Fink, M;n.
Profbssar of Psychigtry
Mn:

MP/iJ

�</text>
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                    <text>73$B~536

February 16th, 1973

Kathan S. Kline. M.D..
Research Canter,
Roeklnnd state ﬁcnpital,
OrQngcburg, H.Y.

Boar Hate,
You 3:: asking ‘ difficult qnettion when.you enquire
my schedule this aunmar. ﬁlth some luck I will be
to
as
in ﬁning in August. but should lean. fbr Europe in zinc
to be in Hurseillan septanbcr 1»?.
I will prdbably'be in Europe also during the month
of June. pmobdbly lata; and a third trig will be late in
Getober as I mutt be in Amaterdnm on.0ctoher 27th.

Sinoorely yours,

Fink. M.D.
Profcsaor of Psychiatry
Mix

MF/iJ

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                    <text>May 31 . 197’;

Jovan Simeon, M. D.
Missouri Institute of Psychiatry
shoo Arsenal Street
St. Louis, Missouri 63139
Dear Javan:

I am pleased to enclose a copy of the report on the
peptides which I gave at the EﬂDEU Meeting. Should you be interested in developing such a program, I will do whatever I can

to assist.

my

best regards.
Sincerely yours,
Fink, M. D.,
Professor of Psychiatry

Max

MF:ed

Enclosure

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                    <text>WW.

.7“

.

y,

x

v—r-u.

.«rw ~»r-wu.-_——nww- ‘lu—P'r—KyH—IWrwm‘ﬂ—HnVn

mm.

“Mm.

vam-

m.

7“ mymw-wm.mmuwm w..."- mw...-n-—.

1...

.«w—n. wan-mun.“

.

-

‘ww‘F/W p":- w- n WWI-P. «nun-1w. -.v..——v-—.~
x

4»/
November 21, 1977

Nathan 8. Kline, M.D.
Rockiend Research Institute
Orangeburg, New York 10962
Deer Nate,

read the file on Dr. Vacant G. Joehi with some interest. As
observations, it is that INH plus Vitamin B6 served to
case of catatonia. The patient had two EEG records done,
receiving INH. There was a remarkable change in the EEG,
characterized by the appearance of generalized, dominant slow theta activity
which became more intense with hyperventilation. Dr. Joshi notes that he
has used.the combination in other schizophrenic patients with success.
I am not surprised by his report. It is consistent with two sets of
data. The response of catatonic patients is notoriously rapid when any change
is induced in the CNS. Thus, barbiturates, amphetamines. and BCT have each been
successfully used in catatonia. The most interesting is the latter, A recent report
by Breakey and Kala (British Medical Jounnal 2: 357~359, 1377) finds that
ECT-wcs remarkably successful in relieving more than a dozen cases of catatonia
after typhoid fever. The predominant finding in ECT in the EEG is the development
of high voltage slow waves in the theta range which are responsive to hyperventI have
I understand his
relieve a single
before and while
.-

.

ilation.

The other observation is that of the association of EEG and behavior
after psychoactive drugs. It is clear that any compound that alters brain function
witl show its effects in the EEG, and when such effects are observed by clinicians,
the EEG patterns will be clear and will follow predictable patterns. Dr. Joshi's
paper suggests that the high doses of INH which he is using do have an effect on

the

EEG

similar to

BC?

or antidepressant drugs.

It is not possible for us to corroborate Dr. Joshi's findings. We
could cooperate with other clinicians whb wish to duplicate his observations

by carrying out the EEG analyses on records collected in another site, if the records
are collected on tape compatible with our recorders. We also lack the funds
for a research fellowship at this time, although
is possible that you and the
other Research Directors may be making funds for fellowships available.

it

and I

for the opportunity to read this interesting communications
congratulate Dr. Joshi on his fine observations.
Thank you

Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

w—n—u—

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                    <text>April 6,
Dr. Jerome

1957

J. Klinnan

1001 City Avenue, unp907

Philadelphia, Pennsylvania 19151
Dear Dr. Klinman:
Your letter to Dr. Freedman has been sent to me for reply.
The Department of Psychiatry is rapidly expanding and I believe
that opportunities both for you and your wife exist in this
program. Amng the more rapid growing parts of the Department

are the units for partial hospitalization, a rapid treatment
and a study progran in narcotic addiction.

unit

fortuitously, there is a special Opportunity for your wife,
insofar as the present chief of the Division of Psychology
is
stepping down frcm that position to devote more of his time to
a research program in rapid treatment.
,

In the expansion of these prograns, emphasis is given to
the evaluation of the treatment ardto the study designs which
may make this possible. To minimize the variability inherent
in a large staff on a very part time basis the appointments to
the Department since last sunmer have largely been made on a
full time basis and only on occasion at twee—quarter or half——
time.

I would be pleased to have an opportunity to meet with both
of you and to discuss the programs of the Department. Is it
possible for you to visit New York? If so, would you care to

call my office at
suitable time.

Thank you

212 369—7900 Ext. 248 and

arrange for a

.

for your interest.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry and
Director of Clinical Services

Max

MF2kp

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="106827">
                    <text>731*7581

13 Novambor 1973

HE. Rs Jo “YWCJ-l

Contracting Officer
Contrscts Kansgsnent Branch
Rational Institute of thtal Koslth
5600

Fisher‘s

Lane

Rockvills. Maryland 20352
Ra:

BSM42~7D~98

Dsir Ht. Gradwell:
Encloscd in s oopy of s latter I have none to Dr. Stephen
scorn. reporting progrsss in the study "Chronic Hashish Users
in Graces" (35H 42—70u98). Progress on this study has bean
ontstsndinaly good. with the stooption that tbs timetable which
tho Committee insisted upon in Junc-oanaot to not without totni~
noting the study in an incomplote ttsse. I am, therefore, re~
qussting an axtension to April 30, 1974, and havs outlincd in
my lotto: to Dr. Saar: the tsssons thstsfoto and the
state of
tbs study during my visit to Athens on Novembat 7 through
9.
Should an extsnaion be possible. tho Association will prs~
puts the nsoasssry supporting documonta. Should the Connittos
rocouusnd tsrminstion on Doesﬂbor 31. us will submit s final
taport. oopias of all of tho dots. otc.. according to the oon~

tract .

Should you wish additional infatuation, I suggest you die—
enaa the progress in the study as witnssood by Dr. Stars and
3:. Smith during their visit to Athens in August.

It is a pleasure to work with you, and I trust we can bring
this extraordinarily incarnating study to a satisfactory tomplotion.
‘

sincerely yours,
Max

Hrlcis
Baal.

Fink,

M.D.

�</text>
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              <elementText elementTextId="58263">
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                  <elementText elementTextId="106749">
                    <text>Mty

7,

1973

Harold Mnilullﬂ. M.D.,V1ee—Chnirmnn

Narcotics Addiatinn Control Commisaian
less‘arnaduuy
Nun

thk.

Nan-Ybrk

10033

Baa: Hiﬁbld:

I have Joined tbs iteulty of thc Health Sciences
the
Univaruity of New Ybrk st Stony Brook. Effective
It 1973 State
Roanick ha; teeuptud full responsibility,
Dr.
Richard
Int,
under thy suporviuton of Dr. ﬁltrud M. Fraudmnn. fbr thn scientific
3:9Icta of the contract bctunan tha Narcotics Addiction Central
Commisuian and the Nan Ybrk Medical Callas: {by thy study of narcotic
Intngnntsti and m-rijunnn.

As you miy knnu‘

Cantor

th

At Dr. Pruadmua’l request. I will continue
as long ts 1t 13 mutually antral.

ta assist Dr. Rennick for

For record purpesaa I unuld suggest that yen notify the various offices
that all communicatiaan be diraottd ta Dr. Freedman; axeept for theta
and these ohauld be sent
which would ardtnnrily be d1r¢ctcd ta mu
Raw
B.
Mbdicul
R1ch¢rd
Ybrk
Dr.
Roanick,
to
Callegt. 5 Bart IDan Strict,
Haw Ybrk. New Yank 10029.

..

It

has boon n.9130surc to wank with yau than: many years and I hogs
thnt it will bu poaniblo ta rouontablilh a wanking rulationuhip through
Dr. Yallas at Stony Brnok. my best personal regards.

Sinauvaly,
mfajr’

ccznr. Richard
Irvin B. Schwartz

B. Rulniek

Mix

Pink.

M.D.

�</text>
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April 9th, 1973

Jenn 81mm, 3m”
Missouri Inititute of Psychiatry.
shoe Arsenal Street.
m6 631”:

5%.

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3m.

have read the paper "Acute Behavioral Effects
of Doxepm, Immine- and mum”. While the
clinical material is quite good, I believe 1:11: EEG
12

alumna

to

with you.
My

come

I have given

to Peter: and
as ”have had a.
it.
some
to
conclusions, I will be in tench

should be updated.
asked him to reviw

As soon

a.

copy

best regards to Susan.
Sinceraly ymn's .

ﬂu: mm, 24.3).
Profassor of Psychiatry
WI 13

.

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mm~mww~u~ wnwwv-n-

,

&gt;

....'

__w .NQ.W..WW_W_ “ v v7w. i,"

_.

V

wwwrw—ww-v—w-w—p—i

—w,r~—

July 23, 1971
Dr. Robert Knights

Carleton University
Ottowa, Canada

Dear Dr. Knights,

Following your letter, I called Donald Cheetham at
Smith, Kline &amp; French Laboratories and recommended he get in
touch with you, when and if, they decide to go ahead with the

evaluation of the

DOB

compound.

I have read your reports and have found them most

esting. I have sent them on to
for her information.
Our

may

my

associate,

inter-

Dr. Rhea Dornbush,

study in Athens seems to be 'off the ground' and

yet fly.

in the studies in Jamaica. Perhaps, on your
next trip through New York, you would have the time to visit
Good luck

with us

?

(212»369-7900).

Sincerely yoursm
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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3.“

art,

imvw

T
m.“

'1’v/V")r&lt;n

——-

January 23, 1985

w‘wuvv-r—v

,

new

.vwm—

Walter Knopp, MD.
Department of Psychiatry
Ohio State University

ll73 West 12 Street
Columbus, Ohio l432l0--1228

Dear Dr. Knapp,
I attended the ECT conference and prepared a summary of the
proceedings, for publication in the News and Notes section of the new journal,
CONVULSIVE THERAPY. Volume 1 number 1 is at the publisher's and will appear
in March. I enclose a pre—publication draft of that summary for your use, as well
as a copy of my report.

Sincerely yours,

Max Fink, MD.

Editor

�</text>
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                    <text>September 20, 1968
Dr. John Knott

Department of Psychiatry
University of Iowa

State Psychopathic Hospital
500 Newton Road
Iowa City, Iowa 5224l

Dear John,

Enclosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annual Review of Pharmacology
(l969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I will try to summarize the best parts of the material for
technicians and send it to you shortly.

Thank you

for your interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

ox

�</text>
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,1.”

vumwvmwv‘m‘-

September 20, 1968
Dr. John Knott

Department of Psychiatry

University of

500 Newton Road
Iowa City. Iowa 52241

Dear John,

Enciosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annuai Review of Pharmacology
(1969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I

'1!

wiii try to

summarize the best parts of the material
it to you shortiy.

technicians and send
Thank you

for your interest.
Sincereiy yours,
Max

MF:kp

u»

1W

guy—p

r'u

-

wusznmrwnmnm~w

V

Fink, M.D.

Professor of Psychiatry

-v~rn}'w

Wye-a.

Iowa

State Psychopathic Hospitai

DL‘

for

�</text>
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                    <text>October

5

, 196%

Dr. John R. Knott
PsychOpathic Hospital
Iowa City, Iowa

Dear John:

It was a very pleasant meeting in Santa Fe and I
think a very productive one. I an writing to ask you to
please send me whatever information you may have available
regarding suggestions for the training of EEG technicians.
I would like to provide Dr. Itil, who is training our technicians, with as much as a guide that you may mommnd.
Sincerely yours,
Max

Fink,

Director

Inf/ls

M.D.

�Octdber 6,

196%

Miss Stacey Saley, Medical librarian
Arany Lorand Memorial Library

Hillside Hospital
75-59 263rd Street
Glen Oaks,

New

York

Dear Miss Saley:

I

have checked

my

books and neither ohe are on

at the present time. I
fate has been.

am

sorry that I

do

not

my

Sincerely yours ,
Max

Fink,
Director

Inf/ls

M.D.

book shelves

know what

their

�</text>
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                    <text>October 15, 1979

Peter J. Knott, Ph.D.
Marshall University
Huntington, West Virginia
Dear Dr. Knott,

principal recent publication devoted to studies of
mianserin is the special issue of the British Journal of Clinical
Pharmacology, Supplement 1, volume 5, 1978, titled "Proceedings of
a Symposium on Mianserin- October 1977". This should be in your library.
The

As

best as I can

tell,

the spondors of mianserin are

clinical trials necessary to establish an NDA in this
country. I have no knowledge as to when it is likely that it will

doing the

be introduced.

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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              <elementText elementTextId="63633">
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                    <text>?
October 9,

Ray

melw,

1961‘

mm.

St. Innis State Hospital
Street
was
St. Innis, Mssmmi

W1

Dear Dr. Knowles:

mm,mhw.wtedﬁmtymhed
Intandngtom‘.
him $16, 000 as Physician 11. At the present
tims,themlesofﬂ1efomdationrequir'ethesalaries
paid be equivalent to established state positions in
the Institute. A l#1:}: year psychiatrist is not eligible
offered

Wise 11% than $12~15,000.
a scale:
for

.

.

3

we have

med as

year res. s $343,000

1:9
+ 1' yew
mass
3
4 2-3 yams
15~15,5D‘O

Iftheseare too-1cm, thenDr. Ulett should review
them. IfDr. Naﬁm'ajoimno. mmdnmoeive
$13,000; and if salaries
st year: end, perhaps
«1

$13,506

or $1u,000.

malmmtoenommdabwteommmbilityinsalaries

Wammﬁnaiveinsﬁm,lhavebeenmtm~
mmmmfmwmrmmmmm
atlelevels,sinoethemmglnatimsamclsar
inthisregard Ifymmmtroquestisapproved, I
womdapprociatsmmviswingtmmommendedsalaries

withestahlietmdznstitutesalmymes.1fthmis

,Imﬂdurgeyoutoreview
anysigxifiemtdi
salarywiﬁamdeUlettbefom
omnittingtheftmch.
~

~

Sincerely yours,
'

Inf/ls
C .C.: We Ule‘tt

A

Max

the,

Motive

ma.

mm
-

�</text>
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              <elementText elementTextId="13087">
                <text>1964 </text>
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                  <elementText elementTextId="104631">
                    <text>April 20,

1985

mm,

Dr. Raymond
Superintendent
3t. Louis State Hospital

Arsenal

5'400

St. Ind»,

M343]:

Stunt

mm

63139

Iwishtotakoﬁxis opportmitytoﬂmxkyoumdymmpmde—

censor, Dr. Kchler, for your support in the devalopmnt of the
laboratories md research progzm of the Missouri Institute of

that the laboratories
integral
Wm.
putofﬂnbepaxmntofpsydxiatwofﬁmmivemityofﬂissm.
No:

have become an

me

Immminghcmimmkeyaandthcatate wusimdtothe
Men
thawing
and from

WWW.
for patients to
the Universities
attmding matings

Institute in 1962. 01:11.11ng
most helpful in providing
the Institute, staff

mm

at

bath in St. Louis and Ooltlabia. and for the transportation of

official visitors to the Institute.
Thank you

for yam assistance.
Sinoamly yours ,
Max

m,

M. D.

Professor of Psychiatry

MF:kp

cc:

Dr.

Ulett

�</text>
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                  <elementText elementTextId="101952">
                    <text>Mr
_
-

12, 1965

Professor '3‘. Eobayashi.
Departmnt cf mamcelcgy
Univemity of Chiba
313 Inohma
who
(ﬁnk-$11
-—

Japm
Damp

measaor Kobayashi:

me C.I.N.P. Program Camittee for tha forthming mating
in Washington on Hard: 28-31, 1988 has asked Dr. Philip Bradley
and myself to amga a
on the general topic of mumWe haw decided to
a symim on the
phagmaolggy.

swim

sub eat: 0

:

mmmmm
Mﬁmnnargic hallmimgms
mums

my:

W3.

maidamblc study

have meeived

um

the problem of antral
system
in
the therapeutic effects of various
dwlinergic
somatic mum-its , and tn the special pmblm of the dissociatim of me. and behavior.
and the data

tea

mm»

m was,
.

Recognizing your expnrienae with

and your

interest in these problem we would like to invite you to
participate in this symposim.

1. If you an ablaze to exempt this invitatim, mule! you
please send me a mused title for yam pmsentatim, and a

smnpuugmphdasmibingmfm mdtypeofdatayonwiah

to present?

WW

Upon receipt of mean
, Br. Bradley and I
will make up a
the time for
balmcing
prom
pmsmtatims mad dismims. m C.I.N.P. Cmittea has
agreed that this aymposim will have at least one session of
twanlatim, so that reports may be
63016:.
in the 1mm 61'
2. me c.1I.N.P. anticipates mat cad: participmt will pay
his om expenses in attending this mating. For those attending

Wand

simltm

from Burma,

W

a.

'

marker flight may be organized by

Wad
Dr.

Philip Bradley.

�Professor

Matti

I

*2“

12 , 1965

In em amt mat travel ﬁnds are necessary, please indicate:
the mount museum! to supplant your available fwd: and m
willtzmsmit
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                    <text>November 9, 1966
Dr. Werner P. Koella

Senior Scientist

The Worcester Foundation

Shrewsbu'y, Massachusetts 01545

Dear Werner ,

for your kind invitation to participate in the
meetings. I will do my best to prepare a manuscript and
hope to have it available at the time of the meeting. I am
going over the data now with my associates in St. Louis and
do not think that I will have the manuscript available until

ACNP

Thank you

December 1.

Incidentally, much of what we present may be more appropriate
as discussion or immediately following Dr. Martin's presentation,
since I believe the two discussions are more closely related.
Sincerely yours ,
Pink, M.D.
Peofessor of Psychiatry

Max
gm,”

.e

w"...

for Experimental Biology

111ka

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                    <text>December 19, 1966‘

Dr. Waner P. Koella
Claim, Study Group III
The Worcester Foundatiori for Ebcperimental
Biology
Shmwsbwy, Massachusetts 015%
'

Dear Wemér,

but

of our report on cyclazooine is now completed,
awaiting the prints for a number of figures. This will

The manuscript

I

am

mquire an additional

two weeks.

If there will

be any unusual

delayinthefigums, Iwillsendthetextontoyousoonerard
indicate
that the figures will follow shortly.

I enjoyed the matings very

you on the program.
A‘My

best mgards'for' the

much and wish

New

to congratulate
'

_

.

Year.

Sincerely yours ,

Pink, M.D.
Professor of Psydu‘au'y

Max

'Mchp

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                    <text>January 10 , 1967
Dr. Werner P. Koella
Worcester Foundation
222 Maple Avenue

for Experimental Biology

Shrewsbm'y, Massachusetts
Dear Werner,
Enclosed are two xerox copies of our report on cyclazocine
at the American College of Neuropsychopharmacology
San Juan in December. I have been dissatisfied with the

as presented

in

figures.

thought,

figures.

SincetheydomtaddasmchasIhadwiginally

I stould like to

Thank you

submit

this for publication witl'out

for your patience.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>E

E

E

E

August 22, 1967

z

Dr. Werner P. Koella

Senior Scientist

for fbcperimental 35.01qu
Shrewsbury, E'ﬁassachusetts 015%

The Worcester Foundation

Dear Wemr,

for your letter of August 17 , suggesting
2'1ave already clone so by
reservations for San Juan.
sending in the form requested to Dr. wittenhom. 2~Ieverthelesss,
I have submitted another reservation t0 him.
rthank you very much

that I

make

I look forward to seeing

you then.

Sincerely yours ,
Fink, Mi).
Professor of Psychiatry

Max

“‘2‘

a,

�</text>
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                    <text>October 18, 1967'

Senior Scientist

The Worcester

'

Emmatim for

3mm, WM 015%
Bear ‘W,
-

m
Ibeliewtlmttm'm
that you fave set up for theiswcial mm is sufficimtly
Wiveﬁmtitmymtmmqwmlyminﬁwtm
Perhaps the time which my be available may better
abated.
used to extend the fmlﬁr
WOW?
Them: you very mach

for your invitatim to‘msent

mitimwldetainmudymxpnh
'

_

'

be"

.

‘

1y.

yours,

*
rm?"

m
m, 9f Psychiatry
WEEW
‘Mcgo'

,

M3216"

cc:

the. 11:11

�</text>
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                    <text>'

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September 27, l967
Dr. Werner P. Koella

Senior Scientist

for Experimental Biology
Shrewsbury, Massachusetts 01545

The Worcester Foundation

Dear Werner,

Enclosed is a final copy of the paper called

Patterns
of Cyclazocine, A Narcotic Antagonist,” which has been revised
following your suggestions. I believe this is much clearer and
I have taken the liberty of bringing some of the experiences
"EEG

up-to-date.

I have withheld the
I believe the story

me.

satisfactory.

figures because none have satisfied
is clear as presented and I trust

other report for the l967
best regards.
The

My

ACNP

will be ready shortly.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc.

�</text>
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                    <text>September 27. 1967
Dr. Werner P. Koella

Senior Scientist

for Experimental Biology
Shrewsbury. Massachusetts 0l545

The Worcester Foundation

Deer werner,

Enclosed is a final copy of the paper called “EEG Patterns
of Cyclazocine, A Narcotic Antagonist.“ which has been revised
following your suggestions. I believe this is much clearer and
I have taken the liberty of bringing some of the experiences
up-to~date.
I have withheld the
I believe the story

me.

satisfactory.

My

figures because none have satisfied
is clear as presented and I trust

The other report for the l967
best regards.

ACHP

will be ready shortly.

-

‘

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>(ﬂ-Kn,I“V-v¢.

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,

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Dr. Werner P;

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1%?

Koalla'

Senior Scientist

‘

.

.

Worcester Foundation ib'r Experimental Eiralogy
Shrawsbury, Massathusetss-Ul546
Dear Warner,[

set your heart on accomplishing
the established mission of having all the ACNP manuscripts available
long before the meeting. I ragret that this will net be possible.
The original review of the literatura is on my desk, but this is
not a satisfactory presentation. in my discussions with Dr. Itil
hammered out a much
While I knew haw much you have

during the past few months, we have, I believe,
significant VlﬁW:0f the ralation of 5E5 changes with psychc~
tropic drugs to behavior., I would like to present a critical re»
View of our experiences and those of many other observers describing
the interaction of drugs, EEG and behavior in man. ‘This will he
available at the time of the meeting.

mare

the principal discussant of this summary. He
is intimately acquainted with my wcrk and with the total world
experience. ‘I have cansulted him and his discussion will comple«
meat the material which I am reviewing..
Dr.

Itil is

while I know this is less than satisfactory,.1 hope that you
will understand my reluctance to send you an unsatisfactory
manuscript; even far yaur ayes only, and hope that the delay will
be

justified
As

by the

results.

soon aS‘I have a

you ans‘arrange

ta

:

satisfactory document-I will send
conias as ynu request.

make as many

Thank yau for-yaurrinéulganca.

SinCeraly‘yours,
Fink, M.B.’
Professor cf Psychiatry

Max

HF:kp

it

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                    <text>amp,

”‘wm—y--.w‘..

m~.——~.

"‘-'.Im"fmwl—rm.

December 28, l967
Dr. Werner P. Koella

Senior Scientist

for Experimental Biology
Shrewsbury, Massachusetts Ol545
The Worcester Foundation

Dear Werner,

Enclosed are two abstracts for your consideration for the
forthcoming meeting for the Society of Biological Psychiatry.

report entitled “EEG Patterns Associated with Minimal
Alterations in the State of Consciousness" represents a detailed
quantitative assessment of the changes in scalp recorded EEG
The

in human subjects receiving minimal doses.of sedative and
stimulant drugs. The ability to differentiate the minimal changes
associated with these drugs suggests, that despite the general
misconception, sufficient data does pierce the scalp in man to
be of value in identifying small changes in consciousness as a
result of drugs.
are also submitting a second abstract, entitled “EEG and
Behavioral Relations of Phantastica in Man” for your consideration.
So much of the present interest in sleep and dreams is related to
the identification of the dream state with hallucinations in man.
The analysis of the EEG and behavioral changes with a
variety of
hallucinogens and our recent classification of this subgroup of
We

‘

psychoactive compounds
theme of the meeting.
May I

productive
My

may

contribute materially to the central

take this opportunity to wish you

New

Year.

a most happy and

best personal regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>:w- nu-.:.—rqny;-ﬂ

December

l,

1967

Dr. Werner P. Koelle

Senior Scientist
The worcester Foundation for Experimental Biology
Shrewsbury, Massachusetts 0l545
Dear Werner,

citation in the article “Effect
Diethazine
on EEG and Behavior:
of Anticholinergic Agent,
Convulsive
of
Therapy" the year is
Significance for Theory
With reference to the

l958.

I look forward

to seeing you in Puerto Rico.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

.

way,” -,

“g

�</text>
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                  <elementText elementTextId="103587">
                    <text>A..,..

.A

....

.....

W...“

V.

—,

vmw.‘mwvmﬂmm
,

"mm-— W w w
.

&lt;

,,

- r:

memww’ww W n. m
..

r

,

. ....,_,

“Wm W’s—nab

Dr. Werner P. Xoella

Ciba-Geigy

Basle, Switzerland
Dear Werner,

written
Regretfully, there are no copies of the report
EEG
methods
analysis.
of
by Don Shapiro and myself on the quantitative
That report was written in 1.966 and described some of the basic
studies upon which we based our decisions to use period analysis,
epoch size, sanpling rates, filters, etc. Since then, we have

altered our programs considerable, based on our subsequent experiences,
and that issue is now outdated.
we have often spoken of a need for a revision of that
volume, but have not got to do anything about

it.

a number of occasions, we have been asked by some
laboratories about our pregrams, and in each instance we have suggestedand
that they would do best to send someone from their unit to our center,
we can discuss your needs and aims, and provide the backgroundin formation
you wish, either Don Shapiro
for a proper EEG analytic program. Or,
or I can visit your laboratories in Basel, and work with you to develop
the programs to your specifications.
On

if

Separately, I am sending you some of our recent preprints
which will describe the results of our present programs.
Incidentally. Dr. Jiri Roubicek, who was a student in
Basel with Sandos,
my laboratory for more than a year, is now resident in
the
qucmtification aspects,
and while he does not have the experience for
marvelous
he
is
a
person.
meeting
him
enjoy
for
may
you
My

best regards .

sum

-

w"

w

r

"lrrw-qu

wry-wan.

mpwvam—uw

”p.”

a.

November 1, 1971

w—u..«,.~w....—.

A—

.

Sincerely yours,
Mas:

Fink,

M.D.

Professor of Psychiatry

W

�</text>
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                    <text>June 11, 1962
Dr. Louis Kohler

St. Louis State Hospital
ShOO Arsenal street
St. Louis, Missouri
Dear Lou:

letter to Dr. Edwalde,
of
letters
including
documents
and the supporting
and
expertrained
well
Edwalds is
reference. Dr. View
of the qualifications of the
in
but
ienced,
and the interview that Dr. Ulett
letters of reference
and I had, I would be reluctant to make any definitive
Enclosed

is

a copy of my

senior appointment at this time.

If his response is affirmative, I will call

My

you.

regards.
Sincerely yours,

Hthp

encl.

Mewaink, Mfﬁl

�</text>
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                    <text>mm 20,

1953

1!“. Louis H. Kohler

Superintendent

St. Innis State Hospital
suoo Ammal

Street

St. Innis 39, Missouri

mar

Lou:

rejoicing, it is fitting and proper
mingtmoo
mtmlookbackatthispaatyewandwmywom.
last eightm months, a research Institute has boon matod. Yew
foresight in the matim of the building and your interest, collaboration and many considerations during these months haw made this
pamjoot possible. I am most grateful for
help, your advice,
and mtly, your patienoo - for these have gimn life to the Institute.
Form, I lodcupmyour leavingwith sadmss, form are losing
a wow supporter. My new associates join mo in wishing you the boat
of success andhappists in your new mums; and good haalth and
many years to enjoy the mil-earned respect of all of us.
My personal best wishes for the New Year, and many,
my move.
In

this time of

ammo]. holiday

m

Sinoemly yours.
ﬂax Fink,

Dimotor

M. D.

�</text>
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                    <text>June 30, 1987
Greta Koinig, M.D.

Allgemeines Krankenhaus der Stadt Wien
Psychiatrische Universitﬁtsklinik
wahringer Gartel 18-20
1090 WIEN
AUSTRIA

Dear Greta,
Because flights to Kennedy Airport are so irregular, it is not feasible to
meet arriving passengers. When you have cleared customs, find the telephones for
suburban limousine services, and pick up the telephone which is labelled "Long
Island Limousine Service” or "Winston Limousine Service (Long Island)". Tell the
operator that you wish to go to Stony Brook (Railroad Station). When you know
what time you will be arriving at Stony Brook, let me know and we will pick you up
at the station. (Or call from the station; we will be about 15 minutes away.)
Or, call me before making limousine arrangements and 1 will explain again.
at work (516 MW 2929) or at home in the late

i can be reached most days
afternoons (516 862 6651).

We will make arrangements for your stay.
My

regards to Gerhard.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�April 25, 1937

Greta Kolnig, M.D.

Allgemoines Krankenhaus der Stadt Wlen

Psychiatrlsche Universltlltsklinik
wantinger Gurtel 18-20
1090 WHEN
AUSTRIA

Dear Greta,
We should be in New York dorlng much of July. While I will not be ‘on
service', I will be able to have you meet my associatos and work with us on July 13.
I

will arrange some accommodations.

When your plans are finalized, let me know. I can be reached most days at
work (516 #44 2929) or at home in the late afternoons (516 862 6651).
My regards to Gerhard.

Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>December 21, 1988
ml—m'vr

,-

ﬂaw”

w».

www—r—r—,~

GretaKoinig, M.D.
Psychiatrische Universitéitsklinik
Allgemeines Krankenhaus der Stadt Wien
Wilhringer Gurtel 18-20
1090 VIENNA
AUSTRIA

Dear Greta,
What a pleasant surprise to receive your informative letter and greetings.
have regularly received news from Vienna from our young Ph.D. scientist (who
seems to be doing very well in his laboratory work, and his social life).
We

Protocol: Dr. Gangadhar has been a regular contributor to CONVULSIVE
THERAPY and he had informed me that he was planning to study in Vienna. I read
the proposal and it is consistent with our present knowledge and experience. There
are a few points that you may wish to consider.
A study focussed on a defined course of 6 ECT argues that about 1/3 or
of
the subjects will be inadequately treated at that measurement. Whatever
more
benefits ECT may provide, may yet develop with more treatment. it may be better
science to design the study so that that the ratings of depression reach an arbitrary
(though low) value as the time at which the prolactin measures are re-examined.

Prolactin release is influenced by electrode placement, amount of energy
(threshold or supra-threshold), type of current (sinusoidal or brief—pulse), and sex
and age of the subject. One problem with the Siemens Konvulsator is that it
delivers variable amounts of energy. Some attention should be paid to these
variables in the design of the study.
While the study is of temporal

interest, a more illuminating study of
dopaminergic phenemona in ECT might be one of patients with parkinson disease
and depression. Suggest that Dr. Gangadhar read CONVULSIVE THERAPY g: 321327 (Fochtmann) and 3: 189—191 (Fink).
Hypothesis: As for the other questions, I enclose a copy of a report which I
have just sent to the journal Neuropsychopharmacology, and’which is under
editorial review. It is the latest version of the neuroendocrine hypothesis of ECT.

.

"W

wwwt‘

�Dr. Greta Koinig

December 21, 1988

Training: We do not have a formal ECT training program for our
psychiatric residents. in the first year, they receive lectures on affective disorders
and the treatments available; about 3 hours are devoted to ECT. In their second
year, while on the in-patient service, they spend two months on the 'ECT Team',
managing every case referred for ECT. On average,’they manage about 8-12 cases.
ECT is also discussed in the weekly attending case rounds.

Finally, selected residents may do research in ECT duing their elective
period (fourth year) for periods up to six months. We average one resident each
year.

in addition, we have organized a formal hands-on' training in ECT. A
description is enclosed. The next course is sceduled for the week of March 6, 1989.

lPAAE: The details of the lPAAE are enclosed. (The society is changing its
name to The Association for Convulsive Therapy (ACTH.
ECT DATABASE: Citation searches for tapics in ECT are available to
subscribers and contributors to CONVULSIVE THERAPY, by request addressed to
my office. There is no formal citation list that is made up periodically; each issue
of CONVULSIVE THERAPY contains the citations included in the database in the

previous quarter.

There are numerous ways to reach me. Using the University BITNET
system, my address'is MFINKQSBCCMAIL.BITNET. For FAX, my temporary
number is 516- 862 8604 (although this will change in about a month). My home

number is 516-862 6651.

i am delighted that there is a resurgence in interest in ECT in Vienna. i
have been gratified by the continuing acceptance of ECT and CONVULSIVE
THERAPY; its portrayal as a reasonable treatment; the greater investment in
training and improved facilities; and the greater attendance and interest in ECT at
conferences and meetings. The main thrust today is no longer the acceptance of
ECT, nor its indications, nor the technical details of currents and electrode
placements, but in its mode of action. Hopefully, this interest will improve our
understanding of both the treatment and the pathOphysiology of affective

disorders.
1989.

i trust these responses are helpful. 'iy best wishes for a happy and healthy

Sincerley yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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v..—:.m-..:-,--

~»

.uwamm-sdew-was.“ .m "mm... memmmnﬂu...

.—.. mar ..V,_ w“...-

mu

“.v‘

V.....,.wm....

...~.....,... NV.- 1..., ..

w ...

January 15, 1970
Dr. Robert Kokoski
Spring Grove State Hospital
Baltimore, Maryland
Dear Dr. Kokoski:

Recently I was discussing the problem of the measurement
of chemical substances with Al Kurland. He reminded me that
you are running a quantitative laboratory and offered your
services when I had a special problem.

is

a sample which may contain an Opiate and/or
barbiturate.
grateful for a qualitative assay.
be made of an opiate substance,
can
If a quantitative assay
I would be grateful.

Enclosed

We

I would be

will, of course, defray

be incurred.

any costs and charges which may

Thank you very much

for your services.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFPkp

..

.....

.

_

_

, .7

,

,

»

a

�</text>
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                    <text>February 6, 1970
Dr. Robert Kokaski
Director, Drug Abuse Laboratory
Spring Grove State Hospital

Baltimore, ﬂaryland
Dear Dr. Kokoaki,

Thank you for the report of the analysis of our
unknown
of
substance, which apparently contained
sample
heroin. This is indeed helpful, and we are grateful for your

assistance.
at the

NRC

I trust I will have

meetings.

an opportunity to see you

sincerely yours,
Fink, 3.9.
Profeanot of Psychiatry

Max

mf/

�</text>
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V

".7"...

, ....m- ,m

A

-

‘vrym-‘uw

--'"'n"mv-m|n ~,J—a.v1.:m, D’s-Inv'm—p'r.

-

r,

n..- N‘v‘muw-m

mgv..-~w-vmn—.W‘www

.n-uw—w;

~7y.a'-&gt;wav~wwu-~PI“V—Frrf—I'wvw

Fibruary 6. 1970
Dr. Robert Iokcski

Director,

Drug Abuse Laboratory
Grova
State Keepital
spring
Baltimore, Maryland
Dear Dr. Kokoaki,

for the raport of the analysis at car
substance. whiah apparently containeé
Bangle of
heroin. This is inﬁaad hnlpful, and wa are grataful for your
assistance.
Thank you

unknown

a: the

I trust I will hava

was meetings.

an apportunity to see you

sinceraly ycnrs,
Fink, H.D.
Preteens: of Psychiatry

Nan

mf/

1..

~

,

“WV

‘

v

r". “w. (”W— _,

�</text>
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my,”

February 24 , 1967

Dr. Louis Kam’nsky
IBM

1'r’mr‘wzvg.'%vvaﬂmmgnun/Aw:

Corporation

Yorktown Heights , New York

Dear Dr. Kominsky:

I had the pleasure of hearing Dr. Gelernter describe
of his workmile at IBM at a recent ACM meeting. In
the course of the discussion he referred to the pattern
recognition programs deve10ped by yourself. As I am
interested in the pattern recognition problem, I asked
some questions and he suggested that I write directly to
you for the references to your work.

rm,

A

M

some

‘1‘:

'5
,

If reprints of your recent reports oﬁ the pattern
recogxition of the PAP smear are available , I would
appreciate a copy. If not , may I have the citation?
Thank you.

Sincerely yours ,
Ale-'2

Quarry-1"”.

Fink, M.D.
Professor of Psychiatry

Max

.
3“}

Wemﬁfi'IW‘i'ﬁw‘;

,

.

e

"‘43?

_

MF:kp

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                    <text>x;

'Oetdber 29, 1962

Dr. Hewett: Kosi
University of Michigan Medical Center
Ann Arbor, 1416131833
Dear Ken:

last few who have Men quite hectic, ee I have waved q
latex-em free New York to St. Louie. I did, in feet, receive the
kind letter from Dr. ween appointing m u Winter of exhibit:
These

for 1962-63. I wrote to him at that time indicating that I would
rather not serve in this capacity at this time, since I would be
preoccupied by w present change of losetion. Also, the most important
time for the coordinator to function in during the weeks imdietsly
preceding the nesting during May. This rent, the matings of the
Aux-ism Payebietrie Association era hem held in St. Louie, and
mush of w the has been pee-seamed in entieipntian or that nesting.
Dr. Ulett and I will partieipete in may at the best responsibilitisl
during that time and it would be diffisult for me to em out both
functions satisfactorily.
It is, wearers, with regret, that I rsqmet relief from this
assigment for 1962-63. Al I indicated to Dr. Harlan, I would be
played to participate more ”timely in tbs pregrm of the EEG
Society after this year.
My

beet regards,
Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

Max

14me
Planes address correspondeme

m,

Director

to:

Shoo Arlene].

M.

D.

Street, St. Louis 39, Miuom-i

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                    <text>WW

w—--

w‘wime-rm—-W_——~-w_—-—ww“W.m.w-wwwwwunywwm—

-——v

W 11,

1964

Dr. Kaxmth A. Kooi

Sam‘taxy
Univarsity of maxim
Phdieal Canter

Ann Arbor»,

W 12'.

-

maxim

K0011:

Pmmwmmmmmnmfwm
Elactroanaphalomphic Society to the renewing:
mdw

W

M

Institute of Psychiatry

5W0 Arsenal Stmt
St. Louis 39'.

Elam

you.

Sinmmly yours.

W

m M. PM).
PIP/5b

.»

.

u

»

w

._

...

Mum

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                    <text>mm

1r. Kemeth A.

Samtary

11,

196%

Kooi

university of Michigan
Hadioal Canter

pm

Amber,

maxim

Dinar Dr. Kooi:

Plum man w address on ymr mailing list few the
Andean Bhutmenoephalomphie Society to the renewing:
Missouri.

Imtituta of Psychiatry

Arsenal Street
St. Louis 39,
SQOO

mm

Theme you.

Simmly yams,
ﬂax Pink.

Director

MF/jb

91.)).

�</text>
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                    <text>-

Dumber 1“,

1986

Mr. Richard D. Kopenski
EEG

Instruotm

u. s. Naval Hospitql
San Diego, California

.

Deaer. Kopenski:
I am very uuoh interested in your application for a.
positioninthisDapwmntdeantakingtheliberty
of writing a letter to Dr. Debolt and Dr. Spanlding requesting
I have these
references I will process the application further
their evaluation of yaw work-r
Thank you

As soon

as

for your interest.Sinoerely yours ,
i

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>October 12 , 1966

Mr. Richard Kepensky
EEG

Laboratory
Hospital

U. S. Naval

San Diego,

California

92134

Dear Mr. Kopensky:
At the American

Society, I learned of your interest
laboratory early in 1967. We are
establishing a new quantitative EEG laboratory at the New York
Medical College - Metropolitan Hospital Center. Our specific
interest is in oonputer analyses of EEG signals as applied to
the masurmaent of psychotropic drug effects. If you are
interested in relocating to New York, I would be pleased to
Mar from you.

in working in the

EEG

EEG

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 31 , 1966
U. S. Naval

San Diego,

Hospital

California

92131}

Dear Mr. KOpenski:
Enclosed is a statement which I read at a recent meeting
in Madrid, which gives you some“ idea of what we have tried to
do.

laboratory to accomplish this mission is being established.
EEG equipment and unfortunately, the delivery
The canputer equipment should be delivered
March.
date is early
We
in the early summer.
are planning two laboratories, one in an
out-patient facility and one at the Metropolitan Hospital for
A

We

have ordered Grass

in-patients.

are those of the Department of Psychiatry
laboratory in the Department, we
have not yet established any special policies. The working hours
will probablybeanﬁnimnnof fortyhowsperweek. Asilaryrange
is yet to be established._ I would be interested in lowing what
your present salary is andwhat you would be interested in receiving.
The personnel policies
and since this is the first

EEG

You can probably get more information regarding the
and interests of this laboratory by discussion with Dr. LaVerne
Johnson.

I

would be pleased

a statement of the time
salary.

to receive a copy of your curriculum vitae,

when you may be

available, and the requested

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

mfkp

�</text>
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Larry Koran, M.D.
Department of Psychiatry
Stanford University Medical Center
Stanford, CA 94305

1!

‘

Dear Larry,

it was kind of you to write and to give me the news of your work. I enjoyed
much.
it very
I continue on service on the inpatient unit at University Hospital six
months a year with two residents and two medical students during their rotations;
run the ECT service (which is ﬂourishing); and do some research in EEG, as before.
My main work is in editing CONVULSIVE THERAPY, a challenge which 1 accepted
in 1984 and which has kept me busy since.

Our Department has changed markedly under Fritz Henn. We are a
neuroscience center, with good relationships with the V.A. and with the State
services. So much so, that we are planning a new 250 bed psychiatric research
hospital adjoining University Hospital. Planning and architectural drawing funds
have been approved. I have put in my bid to run a neuropsychiatry unit when that
center opens, but we will surely have a large medical/surgical psychiatric unit, as
well as research units for dementia, schizophrenia, and affective disorders.
Meanwhile, Mort Miller‘s successor, Tom Craig left to head a unit in New
and
we are seeking a new Director for the CPD programs. Do you have an
Jersey,
interest to get back into academic research? The position would be good if you

were interested.

Thank you again for your kind words and the reminder that sometimes good
deeds are rewarded in one's lifetime.
My best regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>November 13, 1989
Larry Koran, MD.
Department of Psychiatry
Stanford Medical Center
Palo Alto, California 94305
Dear Larry,
Two events brought your name to mind -- a letter from my son
describing the devastation on the Stanford Campus by the recent earthquake, and
the enclosed letter from Dr. Howard Fenn of the Palo Alto V.A.

How did you fare during the quake? My son’s letter remarked that the
geology buildings were closed and no one could get in to get their records, data,
or computer files. At least not during the week after the quake.
The enclosed letter came ’out of the blue’. Dr. Fenn seems to have
thrown a bottled message into the US. post office maelstrom, and it landed on
my desk. My reply is meant to encourage him to provide me with some data.
Since my image of ECT at Stanford is that it hardly existed until you told me last
year that you had (finally) stimulated its use, I was surprised by the letter. Do you
know Dr. Fenn? Does he ’really’ have cases and the facility to treat? Is there a
mature sponsor at the site?
Meanwhile, our department of psychiatry has emerged, after six years
of metamorphosis, into a department of neuroscience, focussed on brain cells,
receptors, and genes. Our younger clinicians are all devoted laboratory scientists,
with as much experience with rats, rat brain tissues, and chemicals, as with the
mentally ill patients on 10 North.
How is your ECT program progressing?
My best regards.
Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>I

35M

May

Lorrin

r

Koren. M.D.

Acting Associate Professor
E

,’
iii

M;

4. 1978

;»

g

A

Stanford University Medical Center
Dept. of Psychiatry 5 Beheviorai Sciences
Stanford. Ceiif. 94305

Dear Larry:
I have not heard from the Ad Hoc Committee appointed to
review your eppiicetion for appointment. Are you sure that
you
don't want me to write a letter on your request?

If yes, send

me

appropriate committee.

the

name

of the

dean or chairmen of the
My

best regards,

Fink, M.D.
Professor of Psychiatry

Mex

Mszec

�</text>
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                    <text>December 12 , 1966

Dr. Sheldon

J.

Korchin

University of California
Psyclnlogy Clinic
Edward Chem Tolman Hall
Berkeley, California 914720
Dear Shelly,

‘I'hankyulforﬂﬁmdngofmemgerdmgm. Fazio. Since
to the United States by the New York Medical
knew
of his visit and already had recommended him
I
College,
to my associate, Dr. 'mren Itil.

he was invited

He

gave a lectlme here on friday, but unfortmetely

Immaynameetingandmissedhisvisit.

I

Asyoucantell,weheveretmnedtoﬂew’iwk, whenI
ammvmsestablishingeclinicalmsearchprogramwithinm
activemdicelechoolprogrun. Wheanentto St. Louis, it
was to establish a research laboratory, and this has been
accomplished. The invitation to return East was too good,
despite the fact that the facilities and Opportunities were

mificent.
Dr.
my

‘mankymvezymchfortrdxmofmandIhmthet

Peziohsdapleesentvisitheremdmpethethewillfmd

fomer laboratories interesting.
My

best regards.
Sincerely yours,

,

Fink, MJD.
Professor of Psychiamy

Mex

MPﬂcp

�Decanter 12 , 1966
Dr. Slnldon J. Korohin

University of Califmxia

Paychogy Clinic

Edvard Clues Tolman Hall

Berkeley, California

914720

Dear Shelly,
Thank you

for ﬁﬁnking of ma regarding Dr. Fazio. Since

Mmimited totMlhitodStatesbyﬂuNwYorkMedical
College, Ihmofhisvisitandalmadyhadmoaumndedhim
to my associate, Dr. Timon Itil.
He gave

a lecture here on Friday, but unfortunately I

mmyatametingandmiasedhisvisit.

Asymoantell,mhavemt1mdtoﬁew¥ork,wkm1

mmmatablishingaolinioalmaemhmwithinan
aotivomdioalsohoolpmgrm. mmlmnttoSt. Louis, it
and
Ms been

this
to establish a research laboratory,
The
East
was too good,
invitation
return
to
washed.
and
were
the
facilities
the
fact
that
despite

was

Witios

mifioent.
Dr.
my

'marﬂcywverymmhforthirﬂcﬁxgofmandlhmthat

Fuiohadapleaaantviaitfmrearﬂlnpeﬂnthewillfm
form laboratories interesting.
My best made.
Sincerely yams,
Max

Fink, Md).

Profeam of Psychiatry

�</text>
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                    <text>July
.

17 , 1957

Dr. Julius Korein
Assistant Professor of Neurology
Ixiew York University School of Medicine
550

New

First

York,

Avenue
New York 10016

—__w._,

Dear

Julie,

I have read your progress report with great
commendable undertaking to develop the library
of tapes and their analyses, as you propose. The choice of such
analog preprocessing equipment and secondary computer analysis on
a larger instrument was also available to us, but as you know, we
elected to focus on the computer aspects of the problem. With
your laboratory equipped the way it is there is no question that
Both Don and

interest. It is a

to undertake the extensive analyses you suggest.
Don and I have just completed a prelindnary report of our
barbiturate~amphetamine EEG study and I am enclosing a copy of

you are able

the preliminary summary of the data analyses which was the basis
for a discussion with our statistical consultants. When
have had an opportunity to follow this short text, I would like
to go over it with you and perhaps it will provide the basis
for a confiruetory study of your own. Ybu spoke of undertaking
a study with some compounds on an oral, single dose basis, This
project and the preliminary report of more than a year ago, provides
the best evidence that we have that single doses are effective in
changing the

EEG

in the time stated. Incidentally, the

fenfluremine was included as an
is of greatest interest to us.
Don and

report.

My

I both thank
best regards.

you

unknown and

compound

its classification

for the opportunity to read your
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>[1W

,,v”

“rum-W w vemwuwr...

”mm

was.-m..nw,.m—.m-...~1., MW” .., .e-ww.r.r,-.,mww...“we»-.~.«.-rv.--..~.c~~.vvmem-mwwm-vww-«avw WV-Vmw-aw—

December

L

{

:

;

i

?

‘=

Dr.

Ju’orein

New

York

Associ 'rofessor of
550
New

Dear

First

l3, l967

Neurology

University School of Medicine

York,

Avenue
New York lOOl6

Juli,

Thank you very much for the contour maps of EEG spectra.
Both Don and I found them quite interesting. In some ways,
they are similar to the reports presented from UCLA. However,
the possibility that relationships can be discerned in the bi—
spectra which are ., obvious in the usual spectral pictures
makes this tool
interesting one and we look forward to
the further deve .. ent of this program.
‘

sleep figure is probably the most
I hav~
having looked at many sleep figures,
. ed
important.*ver,
so little in this field that I do not know how to comp - end
the figure you present. Is it possible that in the future a
single drug effect may be represented? If one could look at
the effect of a common compound like a barbiturate or the
intravenous administration of chlorpromazine,
it
would communicate much more to people like mysel
thigfi&gt;think
The

deSpite

my

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬂfﬂt

W’ WZWW

L"

�</text>
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Dr. Julius Korein
Dept. of Neurology
H. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue

How

York

Julie,
I

copy of your recent report, "The Effects
Behavior and Electrolytes”, in the g¢§,m.n.;
and any other reports of your lithium/EEG studies.
would

of Lithium on

appreciate a
EEG,

I am sorry we did not meet at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthuaiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her my best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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March 29, 1971

Dr. Julius Korein
Dept. of neurology
I. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue
York

New

Julie,
appreciate a

copy of your recent report, "The Effects
Behavior and Electrolytes", in the J.N.M.D.;
and any other reports of your lithium/EEG studies.
1

would

of Lithiun on

EEG,

I an sorry we did not neat at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthusiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her ny best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Me: Pink, M.D.

Professor of Psychiatry

Hrzkt

ran—W

�</text>
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                    <text>FEW

October 31, 1966
Dr.

550

New

Julius Korein
First Avenue
York,

New

York

Dear Dr. Korein:

.

......_-

"m...—

Dr. Freedman and I would be pleased to have you discuss
a presentation of "Computers in Psychiatry," which I am
presenting at the weekly Department of Psychiatry Staff
Meeting on Friday, Novanber 25. The meetings are from 12:15pm
to 1:30pm on the fifteenth floor, conference hall, at

Metropolitan Hospital.

.
_‘

Enclosed

is a

copy

of a short discussion which I recently
My presentation will

prepared for Dr. Preedman' s textbook.
follow this text rather closely.

I have read your papers with interest, and after speaking
of your favorite moters , I am even more interested to
visit with you. We can arrange it for some day after this
presentation. Perhaps you would also be interested in a discussion
which I recently prepared for a symposium of the World Congress
to

one

which

illustrates

Many

one of these appl'nations , and

this is enclosed.

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Inf kp

cc Dr.A.M.Iraedman

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                    <text>mm

11,

1961:

Dr. 0mm Kemetsky
Daparmsnt cf {max-“smoky
and memutim

Bmtm adversity

Scmol of Medicine
8% East Concord Streat
Boston 18, Mad-twang
Dear Baum

fewweks,whave mviewed Dm'rawe'sm
Wammt
fomd
and
them emellmt. mm, m invited him
mime

tommandvisitusinomartowcrkmttmdctaﬂsofan
He

called marlin: this week to 1:311 m that he
has moidod to take a fellowship with you for additional
appointment.

training. Iminhimmll,mdwewouldin&amp;edbaintmsted

mmgmmmmmmm‘mmm.
In the mam’cim,

who

mm

Many

if you think of marker of your studantsbe

maybe able to participate in our
fw your moonmndatiam.

prom, I shall

thanks.

smoothly yours ,
Max

Fink,

Director
MF/jb

PM).

’

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23m.

Conan

Wtsky,

of Medicine
m1
Wiley
merapeutim

Boston University

W1:
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Bait
of

and

'

Concord Smut
Boetm, 18 Masamwetts
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discussed would like vezymmvisit ywaming the
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mmmmmytima.
m days that am most ammimt for you and ycmr

associates,mwillmﬂcemeamgmts hem.

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October i9,

&lt;7..-

19 87

Tn.

ma.

'Wuw

"

'

vw-rrr".

va

"-Im“w'

ww'mwu-w-

-.-

"K‘Fv'vv-g—W-

Stanley H. Kornhauser, Ph.D.
National Institute of Eiectromedical Information, Inc.
P.O. Box #633
Bay Terrace, New York 11360-4633
Dear Dr. Kornhauser,
Thank you for the invitation to join in membership of the National Institute
of Electromedicai» Information, Inc. I regret that Iam unable to join another
organization, as my time for participation in new ventures is severely limited.
My

best wishes on the continued success of your organization.
Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

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                    <text>February 23, 1988

Stanley Ibmhauser, Ph.D.

NIEI, Inc.

P.0. Box 4633
Bay Terrace, New York 11360
Dear Dr. Konmauser,

Wipt

for
invitation to admit a
EEG
of
with
imagijg
nulti-lead
experience
our
describing
mblication
psychiatric patients. Our work has progressed slowly, and I regret
that we are not in a position to present any useful information at
imam you for the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>April 1.

195:;

w. Bantam Karol

Gaiay Rwandan]. 00.
P. 0. Box #30
my. z, Nat York
,

Dear Bernard:
submit your application 120 the Pumomel
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receive a letter from them wimin
mvision.

macs, which indicates your acme on their
Please send ms that form when you moaiva
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call m and giva me
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,

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�</text>
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                    <text>April 30. men

Dr. Bernard Ker-01
P. 0. Bone #30
Geiw Pharmaceutical Company
Yorkers, New York
Dear Bernard:
We

have received verification:

have been added

that you

to the register as an Associate
Reward: Scientist

(What).

Congratulations

_

z

Sincerely

yam.

Firk,
Director

M.

Max

D.

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