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                    <text>August 1, 1968
Dr. Charles E. Marshall

Associate Director of

Clinical Research
Winthrop Laboratories
90 Park Avenue
New

York, New York 10016

Dear Dr. Marshall:
Some months ago we discussed a study of parenteral
oxypertine in volunteers. I have recently begun such a
study with one unknown compound and it would be convenient
at this time to introduce OXypertine as one of the
experimental drugs.

it

If such
with you.

is possible,

My

I

would be pleased to discuss

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

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                    <text>August
Dr.

Clintin

l,

l968

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine
Baltimore, Maryland 2l202
Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry. Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

Itil and Shapiro, have written
"sleep prints" based on period analysis.

former associates,

on

Agnew,

Parker.

Webb

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (anci others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate. expense. egg.
Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods
of quantification. My associates and I will be glad to do what
we can to make such a symposium a success.
some

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

1m. no.

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                    <text>August

l,

l968

Dr. Turan H. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan,
have modified the laboratory data form to siit some
needs
of this laboratory. We are awaiting a new proof
of the
but I am enclosing a xerox copy of the latest draft available
we

to

me.

This will indicate some of the changes which we have
considered advisable after using the HIP form for the past
few months. These include color divisions between items;

exact values above the place to be marked; the addition of
items for standards. laboratory and route, which we believe

will

be

useful.

on a second form for medical examination
believing that a single sheet on a single side is the best for
and purpose. The laboratory form will be completed by a
We

are working

laboratory technician. We are working on another form to be
completed by a physician and/or technical research person and
this will include such items as weight, blood pressure and skin
and eye changes.
As

soon as a provisional copy

My

best regards.

to you.

is available

I

will send'k

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>August

l,

1968

Dr. John C. Kramer

20l9 Camden Street

Riverside, California 92506
Dear John,
good news of your letter of July 14.
have heard of Irvine,
should be a great
university center, especially if some of the dreams of Gerard
come true in the application of computers to education. I would
be pleased to write a letter of reference. Do you want me to
send one spontaneously or shall I wait until I hear from them?
Thank you

everything

From

With a

for the very

it

I

little

luck I will be in Europe from actober l5~25.

Whether I am hate or not I hope that
you will
visit and I will arrange with my
staff to have you entertained and to show you our present programs.

This

may

not

come to pass.
have some time to

T e marijuana problem
a serious one although today
'l5 a UNQQUG day for me. sinceiswestill
did receive 500 mg of tetrahydro'
cannabinol from NIMH. This represents the supply that Jerry Levine
promised last summer. I was also called by Dan Efren who told me
that Aldrich Laboratories of Milwaukee are prepared to produce THC

for qualified investigators.

of the rumors from Washington regarding CNDA
or Psychopharmacolopy. The latest is that Sidney Cohen of Los Angeles
is taking Roger Meyer's place.
I know nothing

also received a large supply (probably
the world's supply) of naloxone for oral use and we will run clinical
trials during the fall.
In

addition to the

I look forward

THC I

to seeing you.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HFtkp

�</text>
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                    <text>August 1, 1968
Dr. Francis J. Braceland, Editor
American Journal of Psychiatry

l700 Eighteenth St.. N.W.
Washington, 0.0. 20009
Dear Dr. Braceland:

Enclosed are draft copies of two reports summarizing
our experiences with a narcotic antagonist, cyclazocine.
Following theoretical models which have been of interest
for many years, we found that cyclazocine had a neurophysiological profile similar to imipramine. These clinical

trials, in two different populations,
does indeed have significant clinical

indicate that cyclazocine
antidepressant activity.

We are aware that such open clinical studies are
ordinarily of limited value since enthusiasm may effect the

treatment outcome in depressive populations. But the
demonstration of a significant application of available
neurophysiologic methods provides our incentive to present

this publically.
He

and ask

would appreciate your consideration for publication,
that the two reports be assessed together.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc. (2)

�</text>
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                    <text>August 1, 1968
Dr.

Clintin

Brown

Department of Psychiatry and
Behavioral Science
Johns Hopkins University School
of Medicine

Baltimore, Maryland 21202

Dear Dr. Brown:
I have

recently reviewed the available

methods

for

data and find the literature sparse and
unsatisfactory. While many observers have recommended various
computer methods for the automatic analysis of a sleep record,
these are generally very expensive or insufficient. At the
Society of Biological Psychiatry, Ardie Lubin presented some
data from his program in San Diego based on power spectral
density analysis.
quantifying sleep

My

a

report

EEG

former associates,

Itil

"sleep prints" based

on

Agnew,

Parker,

Webb

and Shapiro, have

on

written

period analysis.

and Williams have used amplitude

analysis for the classification of sleep

EEG.

I am confident that you know of others and I am writing
to suggest that the Program Committee consider the possibility
of inviting these workers (and others) to analyze a tape which
can be sent to each of them and to provide them with an opportunity
to describe their methods, ability to discriminate, expense, egg.
some

Such an opportunity would be a great help in clarifying
of the problems facing investigators seeking better methods

of quantification. My associates and I will be glad to do what
can to make such a symposium a success.

we

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: T.

M.

Itil,

M.D.

�</text>
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                    <text>Juiy 31, 1968
Dr. John Biei

Aldrich Chemicai
2371 N. 30th

Company.

Street

Inc.

Miiwaukee. Wisconsin
Dear Dr. Biei:

It was a pieasure to renew an oid acquaintance and
piaased to ask you to provide us with 3 grams of
tetrahydrocannabinoI-A-I (or 9). For our purposes. we wouId
prefer to have this amount made up in ampuies containing
I am

20 mg.each.

We possess Certificate No. 2191 from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federai Bureau

of Narcotics.
As

bid which

soon as a

price is determined,

I can submit

I wouId

to our Administrator.

Good iuck and thank you

appreciate

for your assistance.
Sincereiy yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

a

�</text>
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I'

wee-v.“

an

-

”Liw

July 31,

1968

Ir.

Richard J. Tatham. Chief
Office of Alcoholism and Drug
Addiction Program Development
Government of the District of Columbia
Department of Public Health
Washington, D.C. 20001
Dear Mr. Tatham:

In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori1which
describe our present program and experiences with cyclazocine.
In response to your specific questions. we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

�</text>
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                    <text>Jul y 31. l968
Dr. Ralph Jacobson
Endo
lOOO

Laboratories
Stewart

City,

Garden

New

York

Dear Dr. Jacobsen:
Mr. Kline

delivered the naloxone -

many

thanks.

Dr. Zeks and I are discussing the details of our protocol
and we anticipate the need for placebo tablets at sometime
during the investigation of each subject. would it be
possible for you to supply us with lOOO identically scored

placebo

tablets.

Many

thanks!

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 31. 1968
Dr. Wayne Jostrand
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Dr. Jostrand:
would appreciate a quotation from
purchase of our installed 1800 system.
We

IBM

for the

Thank you very much.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July 31,

Ir.

Richard

1968

J. Tatham, Chief

Office of Alcoholism and

Drug

Addiction Program Development
Government of the

District of

Department of Public Health
Washington, 0.0. 20001

Columbia

Dear Mr. Tatham:
In response to your letter to Dr. Sharoff, I am pleased
to enclose copies of recent reports from this laboratori’which
describe our present program and experiences with cyclazocine.
In response to your specific questions, we have no plans
for the withdrawal of patients from narcotic use on an outpatient basis. The other questions are answered in the articles

enclosed.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

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                    <text>July 31,
Dr. John Biel

Aldrich Chemical
2371 N. 30th

Company,

Street

1968

Inc.

Milwaukee, Wisconsin
Dear Dr. Biel:

It

pleasure to renew an old acquaintance and
ask you to provide us with 3 grams of
to
pleased
tetrahydrocannabinol-A-l (or 9). For our purposes. we would
prefer to have this amount made up in ampules containing
I am

was a

20 mg.each.

Ne possess Certificate No. 2l9l from the Narcotic Control
Bureau and are equipped to carry out research of marijuana as
approved both by the State of New York and the Federal Bureau

of Narcotics.

As soon as a price is determined, I would appreciate a
bid which I can submit to our Administrator.

Good luck and thank you

for your assistance.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE

NEW‘

FLOWER AND FIFTH AVENUE HOSPITALS

mmommum
CORRESPONDE‘

FIVE EAST IOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

July 19,

1968

Dr. Alan E. Smith
Deputy Director

Division of Anti-infective Drugs
Office of New.Drugs
Bureau of Medicine

Food and Drug

Administration

Washington, D.C. 20204
Dear Dr. Smith:

RE:

IND

2822

The studies Of cycloserine, with or without Dilantin
undertaken at the University of Missouri were completed in
the winter of 1965. Unfortunately, I moved from Missouri
in May Of 1966 and have not had an opportunity to summarize
the infOrmation. I have contacted one of my associates
and asked that the data be summarized.

study was discontinued in the winter Of 1965 and
each
the investigators were notified. The unused supplies
Of cycloserine were discarded in Missouri and are no longer
The
Of

available.

Sincerely yours,

W

Fink,
Professor

Max

Mszp

ﬂimwf‘é’“
M.D.
Of

Psychiatry

3

”Ct:

�</text>
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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitts, Jr.

Department of Psychiatry
Renard Hospital
4940 Audubon

St. Louis, Missouri 63110

Dear Dr.

Pitts:

It was a pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved as three months
of work.

are anxious to replicate your study and would be
grateful for an initial supply of one-half molar sodium
We

lactate.

Our discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administration of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor

who

is a third year resident undertaking this study.
Incidentally, I will be in St. Louis on Monday or Tuesday,

August 12-13 and

if

we

can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>PI?

New Yomc MEDICAL COLLEGE
FLOWER AND Farm AVENUE HOSPITALS
Fwn
I
i N

g;
*1

51'

-

*

.3;
A.

5

(7/

00/9538
”FPO/Pr

EAST IOZND 571112111

NEW YORK. NEW YORK 10029

BPARTMBNT OP PSYCHIATRY

.

Ju1y 18, 1968

Dr. Mer1e L. Gibson
Act1ng Director
D1v1sion of Neuropharmaco1og1ca1 Drugs
0ff1ce of New Drugs
Bureau of Med1c1ne
Food and Drug Adm1n1strat1on
Wash1ngton, D.C. 20204
,

Dear Mer1e,
.

Thank you for your Tetter of Ju1y 15. When we have
supp11es of mar1juana we w111 ava11 ourse1ves of the opportun1ty
to ana1yze representat1ve samp1es. I must te11 you, however,
that we have not been ab1e to obta1n supp11es of mar1juana or
THC from either NIMH, the Narcot1c Bureau or the Narcot1c
Contro1 Comm1ss1on of New York. We have, therefore, not under—
taken any stud1es of marijuana.
The recommended doses

app11cat1on.

for

THC

has been 20

mg

for

»)‘
:“fﬁv~€r

‘

-1

*

~

5I
5:935

131.52:}-f’VLIQ‘EVquthAa'Ly"..,.~‘-."E\;"'}"€.,

each
.
m

Every project 1nc1ud1ng that of mar1juana, THC and hero1n
undertaken at th1s Co11ege has met the approva1 of the Cha1rman
of the Department, the Comm1ttee on Research of the New York
Med1ca1 Co11ege, the Med1ca1 Board of Metrop011tan Hosp1ta1
and the Comm1ss1oner of Hosp1ta1s of the C1ty of New York.
Letters of approva1 are on f11e for mar1juana, THC and hero1n
and cop1es may be submitted on request.

S1ncere1y yours,

W

Max

F1nk, M.D.

Professor of Psych1atry

Mszp

a,

-.»

Ii
.3,
4-"),(66ﬁ'

Minna-:3.

�</text>
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                    <text>July l8, l968
Dr. Norman Pitts
Chas. Pfizer &amp; Co.

Groton, Connecticut
Dear Norman.

but

The second oral doxepin study is now being completed
are in need of additional supplies. Would you please

we

send us:
12

bottles -

l2 bottles

—

per bottle

50 mg

-

lOO

25 mg

—

100 per

bottle

We are actively doing the EEG study as well and have
completed three volunteers. I need a few more in order to
establish a definitive doxepin dosage.

Thank you

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July l8.

1968

Dr. Merle L. Gibson
Acting Director
Division of Neuropharmacological Drugs

Office of New Drugs
Bureau of Medicine
Food and Drug Administration
Washington. D.C. 20204

Dear Merle,
Thank you for your letter of July 15. When we have
supplies of marijuana we will avail ourselves of the opportunity
to analyze representative samples. I must tell you, however,
that we have not been able to obtain supplies of marijuana or
THC from either Nlﬂh, the Narcotic Bureau or the Narcotic
Control Commission of New York. We have. therefore. not under—
taken any studies of marijuana.

The recommended doses

application.
Every

for

THC

has been 20

project including that of marijuana,

mg

for each

THC

and heroin

undertaken at this College has met the approval of the Chairman
of the Department, the Committee on Research of the New York

Medical College. the Medical Board of Metropolitan Hospital
and the Commissioner of Hospitals of the City of New York.
Letters of approval are on file for marijuana, THC and heroin
and copies may be submitted on request.

Sincerely yours,
Max-Fink. N.D.

Professor of Psychiatry

�</text>
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                    <text>October 28, l968

J. Levine
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Hisconsin
Chevy Chase, Maryland

Dr.

RE:

Dear Dr. Levine:
During

this year

we

have

MH-l33§8~02

carried out nuaorous trials

of drugs in volunteer subjects whom no have paid a fee of
$l0 - $20 each session. The amount allocated for l968,
$1,000 is now expanded. and I am writing to request transfer
of $600 from Parsonnol or Consultation to Out~patient Costs.
This is an internal transfer and will not effect the total
amount of the grant.
This request is approved by the appropriate official of
the College - the Vice President for Government Relations.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

Approved by:

Mr. F. hayden Morgan

Vice Prosident for
Government Relations

�</text>
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                    <text>October 21, 1963
Dr. William Tabor
Robins Company

A. H.

1407 Cummings Drive
Richmond 20. Virginia

Dear
1
....:-

w

,
-

.

u"

Tag-,1

1;.

.-'MM?,;~"I:_11..

Bill,

Enclosed are a for capies of our interim report of the
studies of Ropoise (butaperazine syrup) in a group of nonresponsive psychotics in a mental health clinic. Previously
we had sent you the case material, laboratory and clinical
data.

Clare and Simeon to revise this for
publication, and look forward to submitting it either to
Cannon: Thehapoutéc.ﬂeoeaach or the Jouanat 05 New Dnugt.
I have asked Drs.

.

my.

man-1w

e

Separately I have sent to Dr. Owen reports of our studies
with Tybatran. I trust he will share these with you. I have
also completed the protocol for AHR~l900 and this will be sent
to Dr. Clark.
Hy

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry
Max

MF:kp

L
L"-

-

two-.-

�</text>
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                    <text>October 2]. 1968

Sr. Fletcher

Owen

A. H. Robins Company
1407 Cummings Drive
Richmond 20. Virginia

Dear Dr. Owen:
In addition to the study of the effects of beatran
in the treatment of opiate dependence. Br. Sharoff and
Dr. Major assessed its merits in the treatment of withdrawal
from dependence on non~narcotic sedatives. An interim
report of those observations is onciosed as well as a set
of case records. Those are submitted for your information
and I trust that these are helpful.

Sinceroiy yours.
ﬂax Fink. M.B.

Professor of Psychiatry

Mszp
8N3.

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                    <text>1

v

:

4

i

A

...

n..."

co.

~—-

-.

.

c

..

October 21, 1958
Dr. J. Levine
Psychopharmacology Research Branch
hetional Institute of Nentel health
5454 Hisconsin Avenue
Chery Chase, Maryland 20203
Dear

Jerry.
I

believe our discussion was most helpful and have
forms requested to Dr. Salzman.

sent the

my files of optical scan rating forms.
copies of the German collaborative forms and
a note that the programming had, as of May, not yet been
accomplished. Our criticism of their form is the high
density packing and the likelihood that machine reading
will be accomplished with difficulty.

In checking

I found my

Sincerely yours.
Fink. N.D.
Professor of Psychiatry
Mex

MF:kp

�</text>
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                    <text>-

-w~

Wru‘ww-a-um

.
«or

WU

31".meﬂ‘¥‘7

October Zl, l968
Dr. Carl Salzman
Program Head

Early Clinical Drug Evaluation Unit
Psychophannacology Research Branch

National Institute of Mental health
5454 Hisconsin Avenue
Chevy Chase. Maryland 20203

Dear Dr. Salzman:
The

data sheets (Biooata 0768) are enclosed and

distributed to the

may

be

program collaborators.
and I do not see the necessity for but have no objection to the
distribution of the HIP laboratory form. but suggest that you

call or.

Itil

Both Dr. Shapiro

ECDEU

for his approval. Additional laboratory data

reports from my files are enclosed. These are derived from
Medical Systems, Inc.. Nathan Kline, Al H. Robins. Geigy
Pharmaceuticals and Sterling—Winthrop.
I look forward to joining you in Miami in December. Since
the principal work on these forms is being done by Dr. Donald
Shapiro, may I suggest that he be invited to participate? As
my travel funds for the year will be exhausted. would it be
possible for your office to support his attendance as a consultant?

Thank you for your kind comments about our
and the copy of the program for Miami.

initial efforts.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>October El, l968

0r. Roland Bonato
The George washington University
Biometric Laboratory

ll45 Nineteenth St.. h.H.

Washington. D.C. 20036
Gear Ron.

It was a pleasure to discuss our interests in the
laboratory data scale. and if the least that was accomplished
was a definition of the need for our laboratory reporting
system. that will have been much.

1px

:',1

12-747mm

'

Enclosed are the figures and a data output from one of
our experiments. The prints reflect the changes in a single
measure over time, with the ordinate being either percent
time (for the individual frequencies). cps (average frequencies)
and relative amplitude. The dev measures are standard deviations.
The abscissa is a number of samples which must be multiplied
by l/3 for number of minutes.

reprint of one of our reports as well as the preprint
of the fenfluramine paper may be helpful in understanding the
The

report.

My

best regards.
Sincerely yours.
Max

Fink. H.D.

Professor of Psychiatry

.

.

.,

Fave-50mm“,

�</text>
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                  <elementText elementTextId="105688">
                    <text>October Zl. 1968
Br. Merle Gibson

Office of New Drugs
Bureau of Medicine

Washington. U.C. 20204
Dear Merle,

It

tor arranging a meeting with Dr. Kelsey.
helpful and we may submit a proposal for FDA

Thank you

was most

consideration.

Enclosed is an additional (copy 3) of the submission
on concentrate fluphenazino hydrochloride. Two copies were
left at your office, and I trust that these are satisfactory.
My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                  <elementText elementTextId="105689">
                    <text>Octobnr 20, 1968
Dr.

Peta: Singlet

Nationnl Drug Co.

Philadelphia, Pa.
Door Dr.

Singlet,

I have read the doocriptivo material of nlntluino
(RDR 3061A) with considerable interest. It is probable that
we are able to contribute to the evaluation of this compound
and I would like to ask you to visit my loborntory on the
occasion of your neat vinit to Row York to discuss this further.
I an taking tho liberty of uncle-ins a dioouooion
from this laboratory which was pronnntod at the recent wanting
an thioxanthonoo sponnotod by the Quebec Psychophurnacological
Association. It will present our point oi View and suggest
some methods which may ho useful with nlotanino.
Thnnk you

for your intoroat.
Sincerely yours,

Pink, M.D.
Profenaor of Psychiatry

Max

�</text>
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                    <text>October 19, 1958
Dr. Fred Clark, H.D.

A. E. Robins Co.

Richmond, Virginia

Dear Dr. Clark,

Enclosed is a draft copy of a suggested protocol for
the evaluation of AHR~1906. This protoool has been approved
by my staff and has been submitted to the appropriate committees
for approval. I as also enclosing a completed PD 1572, and
supplementary oopies of the rating scales and laboratory data
form to be used.

study should result in a olintcsl report,
analyses of the behavioral changes by the Biometric Laboratory
of NIMH, analyses of the laboratory data by Binders, Inc., and
a summary of the EEG patrorna.
The completed

while
before the
within the next
supplies or for
could arrange a
Earth. I would
study of a long
come

there are some administrative hurdles to be over—
study can be undertaken, I believe it can begin
6 weeks. Before submitting a request for drug
grant support. it would be most helpful if you
visit to these laboratories on one of your trips
also like she opportunity to discuss your suggested
acting fenflursmins.

you have had the opportunity to read this protocol,
would you be so kind as to call my office ? Many thanks.
When

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Mex

nil

�</text>
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                    <text>3..

p—vv—w

October

l8. l968

Dr. Michael C. Barry
Hhite Laboratories
Konilworth, New Jersey 07033
Dear Dr. Barry:

l57l for fluphenazine hydrochloride, oral
lOO mg/ml has been submitted to Br. Merle
Gibson at the Office of New Drugs. Bureau of Medicine.
Copies of the submission and the letter of transmittll
are enclosed.
The FD

concentrate,

Would it be possible to ship one-half the supplies
of the concentrate directly to or. ltil at the Missouri
Institute of Psychiatry (5400 Arsenal Street. St. Louis.
Missouri 63l39)? The supplies for Istanbul should be
shipped to me for transushipment as soon as the proper
clearances are provided.

Dr. Itil Joins me in expressing our gratitude to you
and to white Laboratories for your faith in this preposal
and your diligence in making those supplies available.

Many

thanks.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry
Max

�</text>
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                    <text>October

l4, l968

Sheraton Hotel

Juan,
Puerto Rico
San

Gentlemen:

Please confirm a reservation for one single room
l7~2l, l968. I will be attending the ACNP
for
December

meetings and understand that they have arranged for
a block of rooms at special rates.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>October 14, 1968
Mr. John Haher
Bureau of Narcotics and Bangerous Drugs
633 Indiana, N.W. ~Room 510
Washington, 0.0. 20226

Dear Mr. Maher:
Thank you very much

receive a

letter

for your c00peration.

You

should

from ﬁr. Harold Slumberg of Endo Laboratories.

Enclosed is a capy of the report submitted to us by
Dr. Schwarzkoof regarding the analysis of the heroin recentiy

sent to us.
Again

my

thanks for your cooperation.

Sincerely yours.
Fink, “.0.
Proféssor of’Psychiatry

Max

MF:kp

�</text>
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                    <text>n.

mmwmuw—mnww‘

,
,

October 14, 1968
Dr. Haro1d B1umberg
Endo Laboratories
1000 Stewart
Garden City. New York
Dear Dr. B1umborg:
Enc1osed are cooies of ana1ysos by Dr. Schwarzkopf of
of heroin in Novembor 1967 and again in October
1968. You W111 note that the November samp1e was quite pure
and the October samo1o was the one which I discussed with

a samp1e

you.

I wi11 be very gratefu1 if you wi11 arrange to provide
with 10 grams of pure heroin for our research studies for
the remainder of 1969. Mr. John Haber of the Fodera1 Bureau
of Narcotics expressed the w111ingness to de1iver as much
heroin, simi1ar to that ana1yzed by Dr. Schwarzkopf on
October 7, as may be necessary to produce either 10 grams. or
more than that amount. to permit the Bureau to have some pure
me

supp1ies for others.

Thank you very much

for your cooperation.
Sincoro1y yours.

Fink. M.D.
Professor of Psychiatry

Max

Mszp

"v.

�</text>
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                    <text>October
Dr. Louis A. Gottschalk
Professor and Chairman

hepartnent of Psychiatry ano

Orange County Medical Center
lDl South Manchester Avenue
Orange, California 93668

Human

l4, l968

Behavior

hear Lou,

It is

a

pleasure to submit this

Ur. John C. Kramer,

for

a

letter

on behalf of

position at the University of

California, Irvine, College of Medicine.
I have known John since he was a child, for we grew up in
the some community. His father was a general practitioner and
a close friend to my father; and John was a welcome guest in
our

home .

Following his training as a physician, he joined on at the
Department of Experimental Psychiatry, hillside Hospital. as a
Research Fellow. During the period 1959~l96l he was actively
involved in a comparative clinical. EEG and psychologic study
of chlororomazine, imipramine and placebo; and in the behavioral
and EEG effects of procyclidine. In these studies he accepted

responsibility for the selection of patients. their evaluation
and treatment under "double blind“ conditions. In each. his
activities were carried out with an understanding of the
overall program.

Missouri in l962 I asked him to Join me,
was in the far west. He undertook
felt
when I visited him in l965, he was
and
practice in Albuquerque,
assignments at the neoical school.
his
with
teaching
most pleased
When I

but he

left for

that his future

During the

past two years
discussed his interest in

I met him on numerous occasions and
amphetamines and drug abuse.

In these various associations I have always found John to
be a meticulous. sincere, thorough and reliable coworker. he
is careful and reserved. and not likely to be either aggressive

or impulsive.
and thought.

His contributions are marked by careful effort
His principal interests are clinical and he exhibits

the ability to treat with patience the centally

ill

in his care.

�“" “W

‘

'7' '-'-"-“"‘T'-‘"'-r"r—'~‘~m-'-*-r- ~w—ywq.1v-—n——--w—-m«uww~.~~“him-4;.
-

Dr. L. A. Gottschaik

w

\Vr-(‘~'Vr"w

J; ,

w. ,. ,-

--.r_r._w.,-.r.-

v

».\ _.

__,,V, .u—

7.. . n,

1.."

Wm.

,wwnﬂvmmfp

October 14, 1968

-2—

regret that he was as uninterested in coming to New York
as he was to St. Louis, for when I Joined this faculty in 1966,
I invited him.
I

make

I am

pleased to

contributions as

recommend him

a

scientist

highly,

and

knowing

psychiatrist.

that

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

,r
A

he can

“.17

V.

“m

,5 ,W

�</text>
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                    <text>October 10. 1968
Dr. Kar1 Rickeis

Associate Professor of Psychiatry
University of Pennsylvania Schooi of Medicine
203 Piersoi Buiiding
3400 Spruce

Street

Pni1ade1pnia. Pennsylvania 19104
Dear Kar1.

staff member who heard that
Librium
was 40~50 mg/day, we
the maximum c1inica1 dosage of
instituted a review of our experiences here. It was obvious
that our staff uses higher dosages in our Henta1 Heaitn Ciinic.
Fo11owing the suggestion of a

Before submitting this for pub1ication, I wouio appreciate
your comment, from your experiences with anti-anxiety. whether
this presentation has any merit.
Many

thanks and

my

best regards.
Sincere1y yours,

Fink. M.D.
Professor of Psychiatry

Max

Mszp
8110 .

�</text>
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                    <text>my"

.—

.Nn

”‘5‘

w-

.p

mm

1.,

w

v,-u...y.-u;...«.-.—yi.—.

-

,3

October
Dr. Norman

l0.

196$

Pitts

Chas. Pfizer a Co., Inc.
Groton, Connecticut 06340
Dear Norman.

part of the review of our experiences in the clinical
we have completed this report which may be of
interest to you. especially in interpreting some of the clinical
data in studies using chlordiazepoxide as a comparison drug.
As

doxepin study,

Sincerely yours.
Fink, ﬁ.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>October 10, 1968

ﬁr. Herman Heisman
Hoffmenn~Le Roche, Inc.
Motley,

New

Jersey 07ll0

Dear Mr. Heisman:

Enclosed are two copies of the final draft report. Before
and indeed before deciding whether
to publish it. it may be useful to have comments from some of

revising this for publication.
your associates.
I am

a draft of the proposal prepared by
these experiences. I would also appreciate
as to the feasibility and merit of such a project.

also enclosing

this staff based

your

comments

My

on

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>v.
V.
..
..

.—

mmmw_wwwwm‘

r-v—rrvmum-m-

w—kum-v

October

l0,

lBGo

0. Cernora
l432 Glover 5troot
Bronx, New York l0462

Mr. 0.

Dear Mr. Corners:
I wont

you for your
know. without

to take this opportunity to thank

cooperation during our tybamote study.
your heroic efforts. we would not have been able to accomplish
as much as we have. I am pleased to enclose a copy of the
summary

sent to

you

will

You

which has just been completed. A copy has been
The data is confidential and I trust that
communicate this wtthin the A. H. Robins Company only.

report

Dr. Owen.

my

Again.

-‘-v*"-m“vr-rvw

ow

thanks for your cooperation.

Sincerely yours.

Wiv‘m

---'L-~

Max

m‘rl'","mr.1r—

m,

wwwwqmpwup

2va

mm:

..
any»

r

Fink. M.ﬁ.

Professor of Psychiatry

«rm-pnqy-w—sm

Mszp

�</text>
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                    <text>rwr‘u «.-

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October 10. l968

E

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s

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7

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é

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Br. Hilliam Tabor

Robins Company
1407 Cummings Drive

A. H.

Richmond. Virginia
Dear 3111,

We have Just completed this interim report of tybamate.
I have sent copies of the report and case summaries to
Dr. Gwen.

to thank you and the A. H. Robins
in
making this study possible.
cooperation
I want

My

Company

best regards.
Sincerely yours,

E

.

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>T0:

Dr. Freedman

FROM:

Dr. Fink

DATE:

October

l0,

1968

Enclosed are three recently completed reports for your

information.

MF:kp

6

f’ i)- ’7

5 I“

q‘ 39

Jf— ?— so

D‘f” 7L1
/‘
I
A!)

(1)45

(7-11»)

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                    <text>October 8. 1968
Mr. Edmund Zerkin
PHAHTASTICA

Beloit, Wisconsin

Dear Mr. Zerkin,
We have reviewed the request by Mr. Gemege for the
submission of an original report for the new journal, PHAHTASTICA,
and zigz‘pleased that my associates agree to send you such a report
within the next few months. The report will detail the central
nervous system effects of a variety of hallucinogene, and will
summarize the data presented in a review article I wrﬁte last
year entitled, 'Neurophyaiology of Phenteetica- EEG and Behavioral
Beletione in Men'.

as the

this

It wee striking to us that you selected the same name
title for 1 your journal. An I correct in assuming you obtained

from Levin

The report will probably be 20~25 typewritten pages,
double spaced with 2~3 tables and citation: sufficient to acquaint
the interested reader with the sources used. The major emphasis
will he on our own work.

have asked a young associate of our etetf, Mr. Peter
Irwin, to rewrite the report focueoed on the students who may represent
the major audience of the journal. we would be pleased, of course,
if the report were included in the inaugural issue.
We

reply.

I trust this is agreeable

and

anticipate your favorable
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>-—

October 9, 1968
wg/zwmm‘:~

:4

-.:.a

.7.-

Dr. John A. Clouson

Visiting Professor of Sociology

Department of Sociology
The University of North Carolina
Chapel Hill. North Carolina 275l4
'

Dear John,
The wasting of the APPA Council will be held at 6:30pm,
October 25, l968 at Sun Luck Imperial Restaurant (935 Lexington,
corner 69th and Lexington).
Ho

look forward to having you with us.

Sincerely yours.

mmrhu.nm.
Secretary

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                    <text>rum”

"'mlrv-“wﬂy—arum

-

a... ~v—w.n—-.w~-&lt;

October 9, l968
Dr. Reese T. Jones
Dopartment of Mental Hygiene
The Langley Porter Neuropsychiatric
4Gl Parnassus Avenue
San Francisco, California 94l22

Institute

Dear Reese,

mr—aw

dawn-nwm'

.m—s

Please excuse the delay in answering your letter, but I
that I could handle additional tapes. I believe

had to be sure

that

I can.

1 have read the draft of
your medical student's report
EEG
examined
records carefully. The record of
the
ano
S. Miller showed very little change except in the samples
which follow flashes. But those samples are too short to
be sure.

shows a decrease in alpha abundance
and
an increase in beta and theta activities.
and in amplitude
I read these records before seeing your letter and wonder if
your statement that Shiel's record showed little change may
not have been in error.
The

record of Shiel

-n~—-;;.www.

As I

showed you

at the meeting.

we

are prepared to provide

print-outs of the EEG samples. statistical changes if the samples
are sequential. and figures of the EEG changos for each of the
variables analyzed. The analyses can be either of period or
power spectrum.

Trwvw-ﬂv‘uﬁ‘l'

&lt;

wwnpw

.4-

raw-rarw-nvu-

quality of your paper record is excellent and we will
“artefact” the saMplos during playback. Assuming that you will
provide multiple drug administrations in the same subject and
that you will randomly assign the sequence to take care of
the sequence effect. and. ideally that you will throw away
the first records in each subject. I would ask that there be
a 2 minute sine wave followed by a minimum lo minute resting
record. To maintain a constant state of alertness during this
part of the study. we introduce eye opening every 5 minutes.
The

-

.- ..../-—1-

.

..~.,~

”.3.—

�D" “"95

-2~

October 9, 1968

Following drug administration. at whatever times you
feel the effects are to be measured, we would need a 15 minute
sample done in the same fashion as the pro sample. You may, of
course, record additional 15 minute samples in an experiment
after administration. It may be worth—
at. say, 1 and 2 hours
EEG
while to take an
sample before your interviews. and again,

either after the interview or the flicker experiment.

not know if we can read your tape and would suggest
manufacture
a 10 minute sample with a different frequency
that you
We
read each one and if the frequencies
will
on oath channel.
them
come out as you put
on, then you can proceed. Re are equipped
3
l
back
to play
at 7/8, 3/4. 7 1/2 and 15 ips. Most of our work
1
is at 7/8. I would suggest you record your sample either at
1

this or

do

3 3/&amp;

ips.

that we provide is a “relative“
amplitude. it is important that the calibration signal from an
oscillator go through the EEG and that the settings of the EEG
not be changed thereafter. If you will ”lock“ your calibration
amplitude to some standard, and although it will very, it will
Because the amplitude measure

do so within a narrow range, and thus give you a good amplitude
measure.

for us
itofeasy
the same

to identify samples, we generally
frequency at the end of the experiment
place a signal
1 minute.
then leave a gap of approximately 2 minutes on the
for
tape and begin our next sample with a calibration frequency not
easily related by a factor of 2 to the one before (gég;, 10, 17,
25, 8, 20. £32,).
To make

Incidentally, in reading the medical student's report, it
seems that subject A had no EEG change, D had an intermediate
change and B and C had the greatest EEG change. Hhat were the
behavioral effects Just before and just after the EES samples?
he will begin our THC studies within the next two weeks.
I have not yet received a legal supply of marijuana but plan
to carry out the study anyway. The protocol is being retyped
and I will send you a copy as soon as I have it.

Please send us

a sample

tape and he will proceed from there.
Sincerely yours,
Fink. M.U.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 9. 1968
Dr.

Fletcher Owen

A. H. Robins Company
MO? Comings Drive
Richmond 20. Virginia

Dear Dr. Owen:
As you know. we completed the series of tybanzato studies
in the treatment of Opiate depenuence in July. Enclosed you
will find individual case sumaries and an interim roport
describing our clinical experiences and our laboratory data.
It is out intention to edit this draft and submit it for
publication in an appropriate Journal.
I want

to take this opportunity to thank you and lair. Genera
which this study would not have

for your cooperation. without

been completed.

Sincerely yours ,
Fink, PM}.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 8. l968

Inglis

Dr. James

Department of Psychology

_

Queen‘s University

Kingston. Ontario
CANADA

Dear Dr.

Inglis:

Dr. Dornbush has shared your letter of October 2. Our
study program of unilateral and bilateral convulsive therapy
is in progress. As Dr. Dornbush may have told you. we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying [CT and

be of

interest to

available.

that

you have

us to read

you may have a new way of
written a review. It would

this review, if copies are

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>October 8. l968
Dr. James Mortal
Squibb Institute

New

for

Medical Research

Brunswick. new Jersey

Dear Dr. Martel:
an experimental supply
x lOOO. He are maintaining
approximately thirty patients on depot Prolixin and now
are introducing a number of patients with a two week
May

I

request. once again.

of Prolixin tablets.

1

mg

trial of oral Prolixin.
Thank you

for your cooperation.
Sincerely yours.
Fink. M.D.
Frofcssor of Psychiatry

Max

MF:kp

�</text>
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                    <text>October 8, 1968

Inglis

Dr. James

Department of Psychology
Queen's University
Kingston. Ontario
CANADA

Inglis:

Dear Dr.

Dr. Dornbush has shared your letter of October 2. Our
study program of unilaterai and biiatera] convulsive therapy
is in progress. As Dr. Dornbush may have told you, we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying
be of interest
avaiiabie._
ECT

you may have a new way of

that you have written a review. It woulo
to us to read this review, if copies are

and

-

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>October 8, l968
Dr.

J.

M.

C. Holden

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Mike,
I have just read your laboratory data scale report to
the Amehican Jounuaz oé Psychiattg and reureed the butaperazine
study in the June issue of Cunnent Thenapeutte Redeaech.
Both are contributions to clinical drug evaluation programs.
and you should arouse considerable interest.

appreciate reprints of both reports. and would
ask in addition that you send me 6 extra copies of the AJP article.
I would

It

are able to read
the data sheets. and I anticipate that you will get some
inquiries. You should know that the MI? program does not
allow for the coding of drug and dosage - these must he added
by hand - and the range of values to be coded is not clear
from the printed form. The dependence on the instructions
leads to coding errors which are expensive to correct.
was kind

of you to indicate that

we

As improvements. we have recently reprinted the form.
making some additions and clarifications. It may be helpful
to send cepies of this form to the enquirers. and for this
purpose I am enclosing a supply. In addition, since you

wish to send copies of the outputs to some who are
interested, there are included samples for this purpose.
he are prepared to read both the HIP and the new form.

may

Keep up

the good work!
Sincerely yours.

'4'.

_,.~,.,

Fink. M.D.
Professor of Psychiatry

Max
I’vw-w-u-MW-rw,

I'V.7:VVW-W"r

at“;

MF:kp

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                    <text>October 8, 1968

Director of Medical Research
Parke. Davis Co.

Detroit, Michigan
Dear

Sir:

We have recently read the report by Smith and Weyl in
Current Therapeutic Research, descibing their study of Zerontin
in the treatment of children with brain dysfunction. We are
establishing a psychophermscology resesrch unit addressed to
children end adolescents in conjunction with the ongoing ECDEU
progress in sdisophrenie. depression and narcotic addiction, end
are interested in the possibility of undertaking e trial similar
to that described by Smith and Weyl.

we would be grateful if s representative of the
medical reseerch department could either cell or visit us, to
tell us the status of the studies of this compound; and the
other studies which way be in progress to confirm these inter~

eating observations.
Thank you

for your cooperstion.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>-:

‘erwvxmwn‘l'r-w-Tw aw

v 1-.

'VIA%.,'"-Muwti'“'-w~n-—uw‘.«_~rrams-1‘"

“nu-2.x.” ..—r 1/.»

v

71‘

.77

~

'&gt;~wl---"

,

“&gt;31 w.

..~v.;

.._v—~.v..m_

«”1. .mi. -...—,._

s

,

.S.

October 2, 1968
Dr. Norman Weiss

Chairman, Program Committee

Queens County Psychiatric Society
109-10 Queens Bivd.

Forest Hi11s,

ﬂew York 11375

Dear Dr. Heiss:
Thank you very much for your invitation. I wou1d be
p1eased to address the Queens County Psychiatric Society

on Tuesday

evening,

November 19.

I wou1d iike to describe recent experiments in the
treatment of various types of menta11y i11 in e commuiity
mente1 hea1th center, emphasizing the use of new drug
forms. p1ecebos. antagonists in narcotic addiction, and
the treatment of acute1y disturbed users of he11ucinogens.

For a tit1e I wouid suggest either “Psychopharmaco1ogy
in a Community Menta1 Hea1th Center“ or "He11ucinogens.
Tranqui1izers and Psychotropic Drugs of the “705."
I 100k forward
and time.

to hearing

from you regarding p1ace.

Sincereiy yours,
Max

Fink. H.0.

Professor of Psychiatry

Mszp

.... V...,.f..s_,

“ ,m
v

.

.

,._,.

v

.,,

,7

is,

V

H

�</text>
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                    <text>October

l,

1966

Dr. Merle L. Gibson

Acting Director
Division of Neuropharmacological

Office of
&lt;-—-

v

Bureau

New

Drugs

of Medicine

Washington, D.C. 20204

“I'lrr-

.

.
,.

Dear Dr. Gibson:

HTS»

‘uaw1ﬂv-

vr'jn‘brs'

av

V.”

A.{.,_,..

~

“
V-

re“;

‘

W'mn’yaWirm-‘wna

wn.u-nw.r-vy

&lt;r~

It

pleasure to talk with you and I am enclosing
copies of our present laboratory out-put, the optical scan
laboratory form and a reprint of an early laboratory standards
study.
was a

submitting these materials in the hope that I may
meet with someone at the FDA who may assist me in obtaining
a better picture of the laboratory standards which should be
used as the guidelines fer new drug studies. It seems to me
that some central study of the range of laboratory tests
results seen in different populations. with different accepted
and new drugs and under no drug conditions could be most useful
in providing the necessary information for evaluation of human
I am

toxicity.

I will be in Washington on October l7 and would be pleased
to meet with you or anyone you might suggest to discuss this
further from 2 o'clock on.
.

Separately we will be sending you an
HCl. oral concentrate, lOO mg/ml.
Thank you

FD

157l

for fluphenazine

for your assistance.
Sincerely yours.
Fink. M.O.
Professor of Psychiatry

Max

Mszp

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                    <text>October 1, l968
Dr. Martin Keeler
North Carolina Memorial Hospital
Chapel Hill. North Carolina
Dear Dr. Keeler:
The Chairman of the Department. Alfred H. Freedman, M.D.,
and I look forward to having you visit on October ll. Your
lecture will be at the Metrooolitan Hospital Medical Center,
at noon. Unless I hear otherwise. I will assume that you will
need a 3 1/4 x 4 projector.

like to

meet you at Metropolitan Hospital
Avenue)
First
at 10:00 am and to show you around
before
that facility
your lecture. Dr. Freedman would like
meet
with
to
you for lunch after the lecture at l:30 pm.
I would

(97th and

I would like to arrange for you to meet with the other
members of the staff Friday afternoon. You may plan on

leaving about 4:00

I look forward

pm.

to seeing you.
Sincerely yours.
Fink. H.D.
Professor of Psychiatry
Max

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                    <text>l.

October

l968

Dr. Martin Keeler
North Carolina Memorial Hospital
Chapel Hill, North Carolina
Dear Dr. Keeler:
The Chairman of the Department, Alfred M. Freedman, M.D.,
and I look forward to having you visit on October ll. Your
lecture will be at the Metropolitan Hospital Medical Center,
at noon. Unless I hear otherwise, I will assume that you will
need a 3 l/4 x 4 projector.
I

would

like to

I

would

like to arrange for

meet you at Metropolitan Hospital
Avenue) at 10:00 am and to show you around
that facility before your lecture. Dr. Freedman would like
to meet with you for lunch after the lecture at l:30 H"-

(97th and

members

First

of the

staff

leaving about 4:00
I

you

to

Friday afternoon.

pm.

meet with the other
You may

plan on

look forward to seeing you.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

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                    <text>September 30, IQot
Dr. Carl Salzman
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
Dear Carl,

data.

that

HIP

Enclosed are copies of sample out—puts of our laboratory
These samples are selected from the butaperazine study
we recently completed. The output is based on the l966

laboratory data scale.

In working with that form for the past year, we have learned
both that there are important omissions, and that the form lists
many tests rarely or never performed. Based on this experience,
we have modified the form and enclose our sample copies of our

present effort.

I would ghke to suggest that duplicate outoputs and
laboratOry forms be sent to the ECDEU investigators and that
this become a subject for discussion at a meeting of the
investigators. In the event that any investigator or you
would wish to have a demonstration of the application of the
form to a definite set of data, we will be pleased to supply
the test forms and carry out the analyses.
I am

also enclosing a reprint of the controlled laboratory
As I
my associates and I completed in Hissouri.

study which

indicated, I have been concerned with the seeming peremptory
dismissal of iproniazid for the alleged effects on liver function.
The data is not too clear in this regard and much of it is
without sufficient control. If a central laboratory review
were established for a variety of new drugs, for standard drugs
and for different pOpulations under no drug conditions. then the
experience might be broad enough to provide a firmer basis for
such decisions in the future. he would like to suggest that
such a record facility be established.
Ron

I look forward to visiting you, Jerry, Bill Guy and
Sonata in hashington. hopefully on October l8. My best

regards.

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

Mszp

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                    <text>amv.—

September 30, 1968
Dr. Jerry Livine
PsychOpharmacology Research branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland
‘

Dear

Jerry,

Enclosed is a copy of my letter to Carl Salzman, sample
out~puts from our laboratory data scale, samples of our
laboratory data form, and a reprint, as sent to Carl.

to visiting you and your associates on
from Europe to discuss this program.

I look forward

your return
My

best regards.
Sincerely yours,

,0»

.—

.

Fink. n.o.
Professor of Psychiatry

Max

2A

-

A

,-

p-‘M"l',l""

MF:kp

.

w

�</text>
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                    <text>.-

wm—s—wwwu-m

September 30, 1968

-

rpmmrp-nn

nun

Dr. Otto Schwarzkopf

Schwarzkopf Microanalytical Laboratory
56-l9 37th Avenue
Hoodside, Mew York ll377
Dear Dr. Schwarzk0pf:
we

would appreciate your analyzing

diacetylmorphine delivered with this

that it is this

compound, would you

measures as previously to determine

It is possible that this

morphine or

inert substance.

Thank you

this

sample of

letter. Assuming
please make similar
its purity?

sample contains up to

for your cooperation.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry
Mszp
enc .

5%

�</text>
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                    <text>September 30, l96u

.
y
.A

my...

Dr. Ali Keskiner
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63159

1..“

..

—.—.n

._

0.."

U,"

,,
.A

_.,.

Dear

Ali,

If you receive this letter on yonr return from Eurone
without having stopped in how York. please call me. luran
and I spent yesterday afternoon talking about you and Jovan
and have volunteered your Joint services for two projects,
both of which should be completed during October.

q-

av”

i
i

He have been invited to make a demonstration of our
butaperazine work at the forthcoming Divisional APA Meeting
in Chicago. November l5-l7. He would like you and Jovan to
be prepared to attend the meeting and present the work none
in St. Louis and new York. The demonstration will include
the EEG-behavioral changes published in Comprehensive Psychiatry,
the effects on EEG and the sleep print, and our experiences with
liquid Repoise. These are our suggestions. We would like your

contribution.

have been invited to summarize our experiences with
long acting phenothiazines for a forthcoming volume on ﬁQQEEQ
Trends in Psychiatry to be edited by Ted Rothman of Los Angeles.
At first he asked for permission to reprint the report in the
Archives of General Psychiatry. Jovan, Turan and I think that
a better report would be a summary of both studies in Missouri
and our study in New York.
We

if

I have

not discussed these with you already, please
you get this letter so that I can arrange

call an as soon as
for your return to
had a nice

visit in

your decision.
My

New

York

for

Turkey and

a work session. I hope you
that your family approved of

best regards.
Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>September 30 , 1968

Daiid V. Reynolds
Conference Greiman

Mr.

Building

18

333 Ravenswood Avenue
Menlo Park, California 94025

Dear Mr. Reynolds:

associates and I have been interested in the problem
of convulsive therapy for my years and are carrying out
studies of EEG changes with unilateral and bilateral currents
in depressive patients. While I do not think that we have
sufficient data to present to your association, we would like
very much to audit the conference.
My

Would

progm?

it be possible for you to send us a copy
Sincerely yours ,
Fink, NJ).
Professor of Psychiatry

Max

of the

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                    <text>September 30, l968
Dr. Robert N. Atkins

University of Rochester
School of medicine and Dentistry
260 Crittenden Elvd.
Rochester, new York l4620
'

Dear Dr. Atkins:
I am pleased to write this letter of recommendation
regarding Mrs. Mary Ann Stallings. Mrs. Stallings was a
research nurse with me at the Missouri Institute of Psychiatry
for more than a year in l965.

In her position with me she was responsible for co»
ordinating a new drug evaluation program. She provided the
necessary liaison between the research staff and service
staff of the Center. She maintained records and provided
data analyses at the end of the study. I found her work
most

satisfactory

and when she

left for

Topeka to accompany

continuing in his training, I was pleased
to recommend her to Br. Paul Feldman. After she had worked
with him for sometime, he not me and thanked me for both
training and recommending her.
her husband

for

I
.

any

who was

hesitation in recommending Mrs. Stallings
position of responsibility or leadership that required

would have no

initiative, understanding and tact.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                    <text>m 'rr‘mw-wawng‘

i

..

.0.

.

.
"7.-..

v.

.,..

..&lt;
..

a

m

WWW.

September 30, 1968

._mn

,
m.

Mr. 610 Niederhold
c/o 6. H. Kays

“hwy"...u-n-n—w-m-m

Nestchester Country Club
Rye,

New

York

Dear Mr. Hiederhold:
Dr. Shapiro and I would be pleased to have you
visit with us on the morning of October l0. Since we
come in from the country ourselves, the best time would
be l0:00 am at the Computer Center, 4th Floor, 5 East

lOan Street.

Thank you very much

for sending the

Manual PL;ACHE.

Sincerely yours,

.1

ram.

w.—

nmw-n—u—w—

Max

.n

Mszp
‘av-w'31l1WI'a‘rI'vr-v

r

urn-u.

,rl'ylwn-tw

..-

mun”...

w.

_

4w:-

we

M

mm."

“mu-”mm"

wwm

a—vrmwmmma-W-

mm-r.

Fink, M.B.

Professor of Psychiatry

w-v—w-m—uw

rupwww

�</text>
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Mr. 610 Niederhold
c/o G. H. Keys

Nestchester Country Club
Rye,

New

York

Dear Mr. Hiederhold:
Ur. Shapiro and I would be pleased to have you
with us on the morning of October 10. Since we
come in from the country ourseives. the best time would
be 10:00 am at the Computer Center. 4th Floor, 5 East
102nd Street.

visit

Thank you very much

for sending the

Manual PLzﬁﬂME.

Sincerely yours.
Max

Fink,

M.U.

Professor of Psychiatry

MF:kp

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—.

September 30, l965
Dr. Robert N. Atkins

University of Rochester
School of Medicine and Dentistry
260 Crittenden Blvd.
Rochester, New York l4620
Dear Dr. Atkins:
I am pleased to write this letter of recommendation
regarding Mrs. Mary Ann Stallings. Mrs. Stallings was a
research nurse with me at the Missouri Institute of Psychiatry
for more than a year in l965.

In her position with me she was responsible for co—
ordinating a new drug evaluation program. She provided the
necessary liaison between the research staff and service
staff of the Center. She maintained records and provided
data analyses at the end of the study. I found her work
most

satisfactory

and when she

left for

Tapeka to accompany

her husband who was continuing in his training, I was pleased
to recommend her to Dr. Paul Feldman. After she had worked
with him for sometime, he net me and thanked me for both
training and recommending her.
I

would have no

hesitation in

recommending Mrs.

Stallings

any position of responsibility or leadership that required
initiative, understanding and tact.

for

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>.. 'w‘tn

Septaaber so , 1968

ﬁr. Daiid

V. Reynolds
Conference Gmixman

Building 18

333 Ravenswood Avenw
Menlo Park, California 94025

Dear Mr. Raynolds:
My associates and I have been interested in the problm
of convulsive therapy for many years and are carrying out
studies of EEG dmwges with milateml and bilateral
in depressive patients. While I do not think that we have
sufficient data to pmoent to your association, we would like
very web to audit the conference.

mats

Would

progm?

it be possible for you to send us

a

oopy

Sincerely yams ,
Fink, PM).
Professor of Psychiatry

Max

Firm};

of the

“VA—r—w—n‘

Ass-—

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                    <text>an,” n... V .q

September 27, 1968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis, Missouri 63ll0

Dear Pete,

to take this opportunity to thank you for the time
in
demonstrating your techniques and for the supplies
you Spent
of sodium lactate. They arrived with minimum breakage and we
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
the continuation of our study.
I want

it

I found my visit so interesting that I discussed
with
Dr. Freedman, who would like to invite you to give a talk to
our full staff. The subject can be a sunnmry of your studies
in anxiety, or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

a

I will call you later in the
date that is acceptable.
My

week and

will try to work out

best regards.
Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

H

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                    <text>,

wt!

.e..-;_

m...-

~wxw..m_~m .- ‘. m&lt;mnvlfmw .mwpgq..."

._

“Wu-w v" 1;» .mvw': .v.w-w=w...w . a...

Haw-«~—rue—m

”n.-

..wu—w

—~-) erma—mua

n...

7...".-.

...w..;w‘w.. ”up.

September 27. l968
Dr. Ferris Pitts
Washington University School of Medicine
Renard Hospital
4940 Audubon

St. Louis. Missouri 63ll0
Dear

Pete,

you for the time
and
for the supplies
you spent in demonstrating your techniques
and we
minimum
with
breakage
arrived
sodium
of
lactate. They
have already used them in two subjects. In our initial experiences.
our observations areidentical with yours and I look forward to
I want

to take this opportunity to thank

the continuation of our study.

it

with
I found my visit so interesting that I discussed
talk
a
to
would
to
give
who
invite
like to
Dr. Freedman,
you
of
be
studies
The
can
a
summary
your
subject
our full staff.

in anxiety. or any other aspect of your research.

There are departmental meetings every Friday at noon and
pleased if you could plan to visit at the end of
October or during November.
I would be

will call you later in the
date that is acceptable.
I

a

my

week and

will try to work out

best regards.
Sincerely yours,
Fink. N.U.
Professor of Psychiatry

Max

Mszp

.

”M17”

,s

-...-.,..H.

7“,...

n...

�</text>
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                    <text>September 25. 1968
S. Karger AG
Arnold Bockiin-Strasse 25
BASEL 11

Switzerland

Gentlemen:
Enclosed are the revised page proofs.

The oni

significant

correction is in the citation for Fink, M. (5, 1964 which should
read; Eiectroonceph. ciin. Heurophysioi. Suppl. 23 (1964).
Thank you for your comment regarding reprints. Unfortunately.
I have no record of requesting reprints. We do wish to order. at
lease 100 with covers. and wouid request your sending me the
appropriate order bianks so that this can be completed. If I
already signed one. would you pioase send me a copy and I wiii
have the appropriate orders made up.

Piease excuse this extra probiem.
Thank you.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>September 24, 1968
Dr. Arnold J. Handell
Department of Psychiatry and Human Behavior
College of Medicine at Irvine

Irvine, California

Dear Dr. Randell:
Thank you for your kind invitation to present a report
of our current electrophysiologic work in relation to psychopathologicsl states. I very much agree with your mission of
honoring Bob Heath for his stimulating work in schizophrenia,
and I would like to participate.

nest relevant problem is the repeated observation of
differences in EEG response to barbiturates (sedation threshold
and pentothsl threshold) among different populations. The 1961
suggestion that unresponsive schizophrenic patients show their
The

lack of response to most psychoactive agents by a lack of response
to injected pentothsl has been under investigation in Missouri and
New York since 1963. The methods of analysis of the EEG have
turned out to be more complex then we first anticipated, so that
the real data available today is still meager. Nevertheless,
if the Program Committee wishes, we would be pleased to review
the problem of responsivity to barbiturates as an index of
dysfunction (altered function) of the central nervous system
in severe psychosis. we can present the recent mathematical
models for responsivity and summarize our recent experiences
in a therapy resistant study in St. Louis.
A

Mbdel

provisional title: Present Status of the Cerebral Reactivity
in Schizophrenia. The report will be written by Dr. Turen Itil

and myself.

Again,

my

thanks for your kind invitation.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                  <elementText elementTextId="102665">
                    <text>Scptcnbcr 25. 1968
Mrs. Pat

Halter

Bibliographic Unit
Brain Information Service
Biomedical Library
UCLA Center for the Health Scicncea
Loo Angelou,

California

90025

Dear Hrs. Whiter:

For many years I have compiled citations concerning the
effects of psychoactive drugs on the EEG. For this reason,
I am particularly intcreatcd in the bibliographies which
were listed as ready for distribution:

Effect of alcohol on the

Effects of Flaredll

on

EEG

(to

1967)

mama; Brain

Activity

Effocts of halothanc on electrical brain activity (1963068)
In addition,

wo

are interested in the manual of standardized

terminology for dhap stages of bacon subjects.
through your office?
Thank you

In

for your cooperation.
Sincerely yours,

Aw

~
.&lt;

Fink, H.D.
Professor of Psychiatry

n

Max

nnm-mrwr-mm.

'wanW—wm~1nwvw—verw-rmmwm

«awn-nu-

-

(1963-:68)

MF:kp

this available

�</text>
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                    <text>September 24, 1968
Dr. James R. Merkel

Associate Clinical Research Director
The Squibb
New

Institute for

Brunswick,

New

Medical Research
Jersey 08903

Dear Dr. Herkel :

Enclosed is the final draft copy of the report ”Depot
Fluphenezine in the Treatment of Psychosis in a Community
Mental Health Clinic" as submitted to Dr. Sanseigne for
his consideration for publication with the other reports
presented at the special meeting in Sitges. May I ask

you to destroy the

draft

copy submitted

earlier.

for the supplies of fluphenezine
enanthate. with the completion of this study. T have
reesested that all patients now receiving fluphenazine
deconoate receive, at their next visit to the clinic,
fluphenozine enenthete instead. As soon as this has been
accomplished we will destroy the remaining supplies of
fluphenazine decanoete.
Thank you very much

The summaries have been completed and as soon as they
are read and signed will be sent to you separately.
Thank you

for your cooperation.
Sincerely yours,
Fink, ”.0.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>September 26, 1968
Dr. Alain Sanaeigne

Squibb International
460 Park Avenue
New York, New York
Dear Alain,

Enclosed is a final copy of the report "Depot Pluphenarine
in the Treatment of Psychosis in a Community Mental Health Clinic."
we would be pleased to have you conaider this for publication with
the other reports from Sitgea. In the event that this publication
is not forthcoming or inordinately delayed, I would appreciate your
release of this draft for aubnieaion for publication elsewhere.
As I indicated to Dr. Morkel. we are discontinuing all
administration of fluphenarine decanoate and are transferring
patients to the ananthate form. he soon as the transfer is
complete the remaining supplies of decanoate will be destroyed.
As you know, fluphanarine enahthata is now available for clinical
use in our Center.

again, I want to thank you for the opportunity to have
and to provide both our Division and the
Department with a new and useful form of treatment.
Once

carried out this study
my

beat personal regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp
013C 0

P.S.

I think if you read this draft carefully you will find
that the difference in incidence in extrepyramidal
effects is probably as much related to dosage problems
as to the drug since we believe we used too high initial
dosages too frequently in the early (FD) phases of the study.

�</text>
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                    <text>tr

“warm

"'im—W'xvl-pfy

«nu-p.cr

.-—....-

q-..”

.-

"4%.“. up"; u—t‘rn.

uni-ll?

.mpw “Ix’.‘n\'ﬁ'v".w’~ru~'.-rvwvn

wvmmu.

.

\(-

v-:-v~v.—

~- ~

m.

~.—-v&lt;.

ww—

“-03...

September 26, 1968
U. 3. Government

Printing Office

Washington , D. C.

Gentleman:
would 11kt to order a copy of "A Manual of Standardized
Termin‘logy, Tochntquas and Scoring System for Sleep Stages of
Human subjects" as preparad by Rnchtachaffen and tales. Would
you please indicate the price or free for distribution, may we
have a copy?
Wt

Sinccrely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mkap

�</text>
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                    <text>September

2&amp;,

1968

Dr. William Guy

ECDEE Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,
Enclosed is the final questionnaire from my staff.
those have been helpful and look forward to a report

I trust
of the results.

Sincerely yours,
Mix Fink, M.D.

Professor of Psychiatry

“szp

�</text>
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                    <text>Saptamber 23, 1968
Dr. M1103 Vojtechavuky
Prague , Caechoslovakh
Bear 3110:,
9b are all saddened by the new: trau Prague. I wrate
to you sown wn¢ks 136 and havu not reeeivad a rayly. wandering that
pcrhtps cantorship interferes. I as taking tbs opportunity of
Dr. Itil'a visit to the wan matting and my hop: that can of your
coworkers will be permitted to ateana to sand the follawtng ta you.

Pcrhapn the tin: to lnava Gauchoslnvakin but cent. and
an. an sra prepared to 1031a: in whatever may is feasible. Tha
laboratorica hara ;re capable of supporting a few more ue1¢ntisu¢
and an wuuld b0 pleasad co 1uv1tc you to join an as a visiting
acicntiat. wt havc enquired a! sh: State Dcpartaant and they indicata
that a visa under the aéucaeional exchange programs can be and;
available within a fan vuaka. 33Gb a visa paraita tho entry of
a seientis: for periods up to 5 years. ﬂhila 1: data taquiro the
return to the naetvn country. w. havm known th:t thin can bu
waived whara tuah retarn in impracticable.

it

Visa.

may be provided through any

v.3. consul

and V.

will institute tha apwlientian forms if ynn wish and if you indicate
where they are to be taut. The visas are goad not only for the
icinntiut but h1¢ dapondaats as wall.
I trust this may not bu naccnsary. but 1! 1t 1:, pluasa
do not hasitnta to in: us know. Dru. Raubtcek and Volavka have
already written from what Garuauy.
My

heat personal regards.
Sincerely yuurs,
ma: Fink, M.D.

ml

Protessor as Psychiatry

�</text>
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                  <elementText elementTextId="102671">
                    <text>Saptamber 13. 1968
Dr. Olrich Vinnr

Psychiatric Renearch Institute
Prague, Czechoslovakia

Dear Dr. Vinar,

I wrote ragaréing she forthcoming meeting
cammittee,
program
requesting a cgange at data. Since
then. tha avnts in Prague as reported here have become more complex,
and we are sure that you are greamcupiad bw these avanta more than
tha GIMP. Knowing that hr. 1211 planned to be at aha WES meeting
to which yen have been invited, I am.taking the liberty of sanding
this lettar with him and analoaing annther fur Dr. chtechovsky. I
a! tha

Sam. waeks ago

CXNP

wanld be

grateful if

you waulﬂ

daltvnr

it

to him privately.

We are aware that tha pranent
political situation may
impede you: grograma in your laboratnriaa. Ha have discussed this
pruhlam at lengzh beta, and we are praparad to offer you an
oppartvnity to continne yaur studies hare. If you wish to join us
in ﬂaw York (at wish re join another laboratory in the U.S.) we

.
.
.
.

will file the neeesmary foxmg tn ynrmit yam to entar this country.
At the pregame time. the State Departmﬁnt 15 aooperativa and will
ﬂak: visas tor scicntifie workers available with m1n1mnm.da1ay
(2-3 vaeka) under the REP-66 exchange student/teaching prograas.
If you will write, at indicate to 9:. 1:11 that such a stem is
in your internat, wm will arrange :9 have swab a vtaa available aither
in Prague or in

any consulaec

in

West letmany,

Anstria, Vranca, ate.

,;

You

v-1;

VFW“,

Wkly-1.:

~

aheuld know thnt Dru. Reubtcnk and Valavka have 1ndieate¢

their desite to jcin us.
I! this 13 of me relcvnncc, or not feasible. I 3:111 look

forward ea working with you on tha Progt¢m Conutttoa cf the CINP.
My

bust regards.
Sincerely yaura.

ml

Fink. pm.
m
rtofosoor of Psychiatry

�</text>
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              <elementText elementTextId="35500">
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              <elementText elementTextId="35501">
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                    <text>.

.

”WWW—1n:.14“

3-

.

.

x“...

v“.

.7.-_-

gr

15‘!!4r,.—~'€K"m‘mu.

‘4.“ hbl‘l-rm‘

..&lt;H..~.-w-.----~

.v'u-r ..

A.,--1-,-«v-.-

w

xW

'w’mwn-wn. .~I—'

September 24, 1968
U. 3. Government

Printing Office

Washington, D.C.
Gentlemen:

like to order

a copy of "A Manual of Standardized
Terminology, Techniques and Scoring System for Sleep Stages of
Human Subjects" as prepared by Rechtochaffen and Kales. would
you please indicate the price or free for distribution, may we
have a copy?
We

would

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mfzkp

‘

v

~;..

,,

r.

.4.‘

--.

�</text>
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                    <text>September 24, 1968
Mrs. Pat Whiter

Bibliographic Unit
Brain Information Service
Biomedical Library
UCLA Center for the Health Sciences
Loo Angelea,

California

90025

Dear Mrs. Walter:
For many years I have compiled citations concerning the
effects of psychoactive drugs on tho EEG. For this reason,
I am particularly interested in the bibliographies which

were

listed as ready for distribution:

Effect of alcohol on the

EEG

(to 1967)

Effects of Flaxedil on Electrical Brain Activity

(1963—68)

Effects of halothane on electrical brain activity (1963068)
are interested in the manual of standardized
terminology for dhep stages of human subjects. Is this available
In addition,

we

through your office?
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Soptonbor 23. 1968
Dr. Olrioh Vinor

Psychiatric

Roooorch

Instituto

Progoo. Crochoolovokio
Dear Dr. Vinar,

Soon rook: ago I vroto regarding the forthcoming meeting
of tho CIR? program oomnittoo, roquonting a change of data. Since
than, the ovnto in Progoo on reported hora have becoao more complex,
ond on are onto that you are prooocupiod by thou: events more than
the CINE. Knowing thot Dr. Itil planned to be at tho H30 meeting
to which you have boon invitod, I on taking tho liborty of sending
this lottor with him and enclosing anothor for Dr. Vojtoohovoky. I

would be

grateful

if

you would

deliver

it

to

him

privately.

Vb Ito aware thot tho present.politicol situation may
impede your orogrooo‘in your loborotorioo. Ho have diocuoood this
problon at longth hero, and wo ore proporod to offer you an
opportunity to continua your studio. born. I! you with to join us
in How York (or wish to join another laboratory in tho v.5.) wo
will file the nocoooory forms to permit you to enter this country.
At the prooont ting, the Btote Department is cooperativo and will

not: visas for ooiootific workers available with

minimum

delay

(2-3 nooks) under tho USP-66 oxahongo otudont/tooching programs.
If you will urito, or indicate to Dr. Itil that such a atop is
in your intoroot, wo will arrange to hurt ouch a visa available oithor
in Prozac or in any consulate in What Iotaony. Austria, Franco. otc.
You

should know that Dru. Roubicok and Volovko hovo indicatod

their dooiro to join us.
If this is of no rolovonoo, or not foooiblo, I

still look
forward to working with you on tho Program Committee of the CINP.
My

boot rogurdo.

sincoroly yours.

ml

no: Fink. M.D.
Professor of Foychiotry

�</text>
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                    <text>September 22, 1968
,

Dr. Ennial Efron
Ed~1n~0hief, ?sychopbarnacology
Ravinw of Frogresa
ﬁbuhtngton, n.c.
Dear Dan.

Enclosed are the gallay proofs at two cf the three
reports which I submitted {or the ’Reviaw'. Theta are a faw ccmannts
that warraut your attention.
1.

EEG

Classification cf ?sy¢hoact1ve

Compounds.

In

this report, tbs only yrcblcn may be the title. ”Raviaw and Theory of
Behavioral Aﬁnociations“ is a submtﬁtle. ané ghould be reset.
2. EEG and Human Psychophurmncology: Clinicnl Antidepressants.
ﬂhnrc are the figuras and the legends ? These must bu included
and I would raquost anather galley proof when these arc submitted.
work of

I

would Ilka to add a few lxnel at aredit for the
and would be gratafui if yen would permit it.

this etudy

3. Rautophyaloloxy of the Phantastica. This

third taper:
available.

My

and

is the

I anticipate racciving the gallay proof

when

best regards.
Sincernly yours,

ml

th Fink, M.D.

�</text>
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                    <text>September 21, 1968

Dr. William Thbor

A.H. Robins, Go.
1&amp;0? Cummings Drive

Richmond, Va. 23220

Door 8111,

Separotoly. I have cont you the data collected in tho
liquid vohiclo. You will find the commotion
for each case, the original case data report. laboratory data bound
together, and the NINE data analyses and cord output. Dr. Clot.
and Dr. Simeon have completed a roport of their findings nod this
is now halo; typed. It will bo sent to you for your comments within

Ropoloo study using the

a week.

I

no

particularty interacted in your

comment: ooocorning

the laboratory data output. You know that this rooulto from programs
written here uoing the HIP laboratory scale. Slooo than. on hovo
cooplotod o review of out oxpotionooo and improvod tho data oolloctlon
form 80 that tho drug data will also appear on the final reports.
Copies of those will be coat to you separately. (stunt we hovo
used tho butaperazino material on our working model, I will take
the liberty of sending sample page; from thooo laboratory reports
to the ECDEU lovootigatoto. I truot you hoot no objection.)
Also, I wont to thank you for tho referral of Dr. Clark.
ouggootion that we unaortake a study of the long term offocto
of toofluramino lo a good one nod I will explore this further. I
will send him a protocol on AHR~1900 this nook.

at:

My

boot regards.

sincerely yours.
Max

ml

fink,

N.D.

Professor of Psychiatry

�</text>
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                    <text>September 20, l968
Mr. Gio Hiederhold

Director,

Computer

Facility

Stanford Medical Center
Palo Alto, California
Dear Mr. Hiederhold:

to thank you for making so much of your time
available to me during my recent visit. I was impressed
that you have done much for the medical school and see
I want

this as

a model

for future medical centers.

The director of our center, Dr. Donald H. Shapiro,
and I would be pleased to have you visit the next time
you are in New York.

Again,

my

thanks for your courtesy.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>.W’vf‘vrv-.t

you in

'R/‘w

“at .,,-

9:.“an x‘A'wn—w‘ﬁf’n‘

.w

-

-.

,

.

.

_

".7

c

_

~~

‘

mun”..—

.w.,aﬁuwn

.,.

~:,.,y...7ﬂ.wv~..~.; "my, .

My, ".7. .- “Kw," ._

September 20, l968

mp,“

.
c

yaw—“WWVO

ywrrnvI-mmvm

&lt;'w’&lt;;u

.

.x

mum-

California State Department of Education
Sacramento. California
Gentlemen:
He would appreciate a copy of your publication “Drug
Abuse Service Book and Guide for Teachers" by Kitzinger
and Hill. This report was described at the recent western

Institute of

Drug Problems.

Sincerely yours,

«rm-,z-mnuv

av:

1
-

Fink, ”.9.
Professor of Psychiatry

Max

MF:

lip

�</text>
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                    <text>me—rr

September 20, l968
Dr. Wayne Jostrand
IBM Corp.
475 Northern Blvd.
Great Neck, New York
Dear Wayne,

to thank you for arranging for my visit to the
Center in Palo Alto. Rich Hunaate was a very co-

I want
ACME

operative guide. I was able to discuss the report briefly
at the Computer Committee yesterday and perhaps. in the not
to distant future, will be looking to expand our core.
for

When

me.

next you write to Mr. Hungate, please thank him

Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

�</text>
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                    <text>‘

F“J-IvIK‘,"

«&lt;1

up

win—H

.wv-v'vptwu-r-n

v"

.r um“.

.

“.25' 151-- “in -~

w

—~.~~v-n7m-rw~-u

mum-.‘rm, . .wwvm-w~m~am

A~&gt;~r~m1~vwmma‘

-

urns—u

”m.wrvawr.l—F»mﬁ mumV‘WEV-wra-NIJVU1W

«an

napalm»: w. ...

-

«n-

Vex-m7

.w

v.

—n

September 20, 1958
Dr. Joyce 6. Small
13l5 Nest Tenth Street
Indianapolis. Indiana 46207
Dear Joyce.

It

was a pleasure discussing the electroshock program
I have reviewed six sets of records of unilateral

with you.

and find no bursts and only small degrees of background
slowing. These records are distinctly different for the
number of seizures from a similar group of bilateral cases.
ECT

When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

will be coming for the
to arrange to have you

New

York

City.

I would,

and I

of course,

anticipate

you

in early December, I would like
visit and go over some of our records
together. When we have had more experience, I would like to
arrange for one of my staff to visit you and to see the similarities
and differences. if any, in our treatment procedures.
ARNMD

Sincerely yours.
Max

Fink.

M.D.

Professor of Psychiatry

Mszn

"z"- :-

»

-.- .,

,—

l'r

,:

w

'v

-

---

:-

.

~~

�</text>
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                    <text>September 20, 1968
Dr. John Knott

Department of Psychiatry
University of Iowa

State Psychopathic Hospital
500 Newton Road
Iowa City, Iowa 5224l

Dear John,

Enclosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annual Review of Pharmacology
(l969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I will try to summarize the best parts of the material for
technicians and send it to you shortly.

Thank you

for your interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

ox

�</text>
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                    <text>September 18, 1968
Dr. Lester

M.

Morrison

Institute for Arteriosclerosis Research

9331 venice Blvd.

Culver City, California 90230

Dear Dr. MOrrison:
Thank you very much

for your kind remarks regarding our

studies of fluphenazine decanoate. You will be pleased to
that we have just completed another study comparing
fluphenazine decanoate and the commercially available fluphenazine
enanthate. The differences between the two compounds are small
and they are sufficiently similar for the enanthato to replace

know

the decanoate.

sure that the physicians at the U.C.L.A. Medical
of fluphenazine enanthate and would be in a
make
the appropriate decioion on behalf of your
position to

I

am

Center know

patient.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>September 17, 1968
Dr. John A. Scigliano

Executive Secretary
ad hoc Merihuane Advisory Committee

National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203
Dear Dr. Scigliano:

In support of our application for supplies of tetrahydrecannabinol and marijuana, enclosed please find the
original of the letter from the Internal Revenue Service
dated September 12, 1968 confirming the official nature
of our special Tex Stamp number 405087 and Registration 127M.
As indicated in your letter of August 23, this letter from
the District Director will serve as an order form for marijuana.

Sincerely yours,

Professor of Psychiatry
Mszp
enc o

�</text>
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                  <elementText elementTextId="102679">
                    <text>September 17, 1968
Dr. William R. Tabor

Robins Company

A. H.

1407 Cummings Drive
Richmond, Virginia 23220

Dear 3111,

I

am

pleased that the fenfluramine material was acceptable.

for being so helpful but it was not necessary
secretary to St. Louis, as Dr. Itil accomplished his
part with his staff. There are no additional expenses.
Thank you

to send

my

Sincerely yours,
Fink, M.D.
th
Professor of Psychiatry
MF:kp

cur-

:vvnvr-

wp

,

�</text>
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                    <text>September 17, 1968
Dr. Edgar Grunwaldt
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Grunwaldt:
Thank you for the ketimipremine placebo. You may recall
patients
that you asked that we discontinue ketimipramine in for
longer
medication
the
been
on
who have done well and have
ketimipramine
on
each
one
have
put
than eight weeks. To do so, we
placebo first and only those who do badly will receive imipramine.
The new

at the

end of

protocol should be

amended

eight weeks.

to give ketimipramine

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

max
MF:kp

p lacebo

�</text>
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                    <text>September 9, 1968
Dr. Norman

Chas

Pfizer

Pitts
&amp;

Co.

Groton, Uonnecticut
Dear Norm,

I look forward to your visit sometime in the next
few weeks. We are actively involved in the EEG study
and I will request a review of the ongoing DoxepinChlordiazepoxide study so that I may have some data when
you come.

In the meantime, would you please send us an
additional supply of doxepin ? The present labels read,
"Sinequan, 25 mg.."l00 caps/ bottle, (white and black
capasules).
Would you
Many

arrange to send lelOO

?

thanks.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                  <elementText elementTextId="102682">
                    <text>Beptcnbcr 6, 1968
Dr. Jamea Mcrknl
squibb Pharmaceutical;
Riv Jeraay
‘Dear Dr. Hhrkol,

ﬁbula you pleas: make availabla an additional aupply

of 10 viala of ﬁluahenazina enanthata for tha continuatian
Wk still have
of our final graupo a! subjuata 7
tau. vials
but thay has: an expiratien data of October 1, 1968. abut it
the heat mtg? with thia remainder 1 In it still to ba uned 7
The data of an: arossaver study is new complete and um
have the case records and the report available for 40 subject.
who camplntad the crossover and 68 who participated. Th:
final copias ara in the typist's hands and should ranch you

shortly.

Thank you. one: again.

for your cooperation.
Sincarely yours.
Fink, M.D.
Professor of Psychiatry

M3:

MF/

�</text>
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              <elementText elementTextId="35662">
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                  <elementText elementTextId="102683">
                    <text>September 6, 1968
Dr. Ed Grnnuwald
Goigy Pharmaceutical:
Ardsloy, New York
Dear 8d.

Attacbad is a tear—aft labs! from the uvntlable aupply
of placcbo for knttmipramina. ﬁbuld it be possible to make
an additional 243106 capsule: for thlo study ?
Wt

have couplatad aha data analysis of the laboratory

on the first kettm1pram1nc stuay. and
within
to
a few dxya *» I an awaiting eons
you
it
xarax copies of the lab ﬁata to make thé package complete.
and tha

HIMH

I will send
My

material

bets regards.
sincarely years.

Fink, E.D,
Professor of Psychiatry
Max
MF/

�</text>
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                    <text>September 6, 1968
Dr. Joeeph 31rd

Sterling Winthrop Institute

Reneeeleot,

New

York

Dear Joe:

I completed the report: of oycleeocine en en
cop} to Dr. Nathan Kline. He has expreeeed
the study. I know of no one in the ECDEU programs
when

entidepreeeent. I pent e

an

intereet

1n

who he: as good a record on he bee, in defining oer compounds. and
may be most useful for you to have him look at oyoleeooioe.

it

Inoideotelly. I have enquired about Tolwin in our community
and no one has been reported abusing this compound in our population.
Some of the etetf thought the: vo ohould look among the Village
population tether than the Harlem scene. A: upon ee my staff returns
from the summer exodus, I will discuss the ptogten with them.
My

bent regards.

sincerely yours,

Mix

Fink.

HOD.

�</text>
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                    <text>7.
[-9
2.

I
5

E

September 4, 1968

§

2

g
a

anagrams?

'
ma"

n—‘uaro

Dr. Harold Meiselas

Associate Commissioner

Treatment and Rehabilitation
Narcotic Addiction Control Commission
l855 Broadway
New York. New York l0023
Dear Dr. Meiselas:
The study program supported by the

New

York

State Narcotic

Control Commission, is focussed on the continuing evaiuation of
the psychopharmacological - rehabilitation treatment model. During
l967, emphasis was placed on an evaluation of dosage range.
tolerance and secondary effects of cyclazocine. naloxone and
tybamate; the role of heroin challenges in the evaluation of
dosage and of treatment; and in establishing a comparison of
methadone and cyclazocine. In addition with USPHS support, we
have evaluated cyclazocine as a clinical antidepressant;
determined its EEG profile in rabbits; and determined the EEG
profile of heroin, cyclazocine, methadone, naloxone and their
‘

.

‘

n-u-m

interactions.

raw-"rmwm,

I'mr‘azu-Pw,

E

E

Copies of reports completed in l967 and to July 1968 are
enclosed, as providing the best summaries available.
These studies are continuing and the present schedule
includes the evaluation of methadone changes in EEG; methadoneheroin interactions; continued evaluation of cyclazocine-methadone;
and a clinical evaluation of naloxone.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.

Mr.

A. M. Freedman
I. B. Schwartz

�August 1968

STUDIES IN OPIATE DEPENDENCE

1967-68

Cyciazocine and Methadone in Narcotic Addiction.
202: 191-194, 1967.

JAMA,

Ciinicai Studies of Cyciazocine in Narcotic Addiction.

J. Pagehiat.,

Amen.
EEG

Effects

of Cyciazocine.

124: 1499-1504, 1968.

Narcotic Antagonist

A

In Koeiia. N. and A. Karczmar (Eds.), Paoceedinga
05

the

ACNP,

1966.

C.

C

Thomas,

Springfield. (in press)

Antagonists in the Treatment of Opiate Dependence.
In Phiiiipson. R.

V.

(Ed.),

Nodenn Taenda

in

Cbmbatting Deng Dependence and Azcoholiam.

Butterworth, London.

(in press)

Intravenous Diacetylmorphine (Heroin) in Studies of Opiate
Dependence.

OLA. Menu.

Naloxone in Opiate Dependence.

Sya.

(in press)

Olin. Phanmacoz. Theaap.

Ciinicai Triai of Cyclazocine in Depression.
Amen.

(in press)

Submitted to

J. Paychzat.

Neuropharmacoiogicai Analysis of Agonistic Actions of Cyciazocine

in Rabbits. Presented at the Soc. 8101. Psychiat., June 1968.
Tybamate in the Treatment of Opiate Dependence.

12-21-67).

(Preiiminary Report -

�</text>
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                    <text>September 20, 1968
Mr. 610 Wiederhold

Director,

Computer

Facility

Stanford Medical Center
Palo Alto, California
Dear Mr. Hiederhold:

I want to thank you for making so much of your time
available to me during my recent visit. I was impressed
that you have done much for the medical school and see
this as a model for future medical centers.

The director of our center, Dr. Donald M. Shapiro.
and I would be pleased to have you visit the next time
you are in New York.

Again,

my

thanks for your courtesy.

Sincerely yours.
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>September 20, 1968

California State Department of Education
Sacramento, California
Gentlemen:
We would appreciate a copy of your publication "Drug
Abuse Service Book and Guide for Teachers" by Kitzinger
and Hill. This report was described at the recent Western

Institute of

Drug Problems.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Mszp

�</text>
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                  <elementText elementTextId="105708">
                    <text>September 20, 1968
Dr. Joyce G. Sma11

1315 West Tenth

Street

Indianapo1is, Indiana 46207

Dear Joyce.

It

was a p1easure discussing the e1ectroshock program
I have reviewed six sets of records of uniiaterai
ECT and find no bursts and oniy sma11 degrees of background

with you.

These records are

slowing.

distinctiy different for the

number of seizures from a simi1ar group of bi1atera1 cases.
When

you have a

appreciate
When

a copy.

next you

draft of your report,

visit

for the

New

York

City,

I would,

and I

of course,

anticipate

you

in early December, I wouid iike
to arrange to have you visit and go over some of our records
together. When we have had more experience, I wouid 1ike to
arrange for one of my staff to visit you and to see the simiiarities
and differences, if any, in our treatment procedures.

wi11 be coming

ARNMD

Sincereiy yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFrkD

�</text>
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                    <text>,.

,1.”

vumwvmwv‘m‘-

September 20, 1968
Dr. John Knott

Department of Psychiatry

University of

500 Newton Road
Iowa City. Iowa 52241

Dear John,

Enciosed are two reports of the EEG effects of psychoactive
drugs. One was prepared for the Annuai Review of Pharmacology
(1969) and one is a summary of the presentation at the 1967
Denver meeting of the American EEG Society.
I

'1!

wiii try to

summarize the best parts of the material
it to you shortiy.

technicians and send
Thank you

for your interest.
Sincereiy yours,
Max

MF:kp

u»

1W

guy—p

r'u

-

wusznmrwnmnm~w

V

Fink, M.D.

Professor of Psychiatry

-v~rn}'w

Wye-a.

Iowa

State Psychopathic Hospitai

DL‘

for

�</text>
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                    <text>September 18, 1968
Dr. Lester

M.

Morrison

Institute for Arteriosclerosis Research

9331 Venice Blvd.

Culver City, California 90230
Dear Dr. Mbrrison:
Thank you very much for your kind remarks regarding our
studies of fluphenazine decanoate. You will be pleased to
know that we have just completed another study comparing
fluphenazine decanoate and the commercially available fluphenazine
ensnthate. The differences between the two compounds are small
and they are sufficiently similar for the enanthate to replace

the decanoete.

I am sure that the physicians at the U.C.L.A. Medical
Center know of fluphenazine enanthate and would be in a
position to make the appropriate decision on behalf of your

patient.

Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

�</text>
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