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                    <text>March

4,

1970

Dr. N. Keop
681 Ciarkson Avenue
Brooklyn, New York 11203
Dear Dr. Keup:

Enciosed is an abstract for your consideration for the
first Muitistate Interhospitai Conference of EPRA. Dr. Abrams

will present this report. If it is at ali possible. he would
appreciate a presentation on Friday since he has a prior
commitment on Saturday.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

enc.

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                    <text>April 9,

1970

Dr. W. Keup, President
Eastern Psychiatric Research Association, Inc.

681 Clarkson Avenue
Brooklyn, New York 11203

Dear Dr. Keup:

In today's mail we have distributed copies of the EPRA
program as you requested. I plan to attend the meeting and
look forward to seeing you there.

Sincerely yours,
Max

Fink, M.D.

Secretary

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                    <text>{Member 13, 1963

Dr.

M.

Z. Khan

Shelton Hospital

31mm.

England

Dcarm‘. mun:

mark you very much for your imuiry. The Missmmi Institute
of Psydliatry is the research and training center of the Division
of
Manta). Mamas of magma. It was established in October, 1962, with
labmtmy and clinical facilities for macamh. At the
time,
of 3.50 beds, we are utilizing 70 four Inseam pwposes.‘ present
Iabmtomiw
are established in
psychology, and electroencephalography;
as well as a water mater for both statistical and BBQ analyses.
Them is a specializeo psyd‘zio‘mic research library
a
part
of the Institute. Animal facilities are now being built.‘
In additim, them is a fully qualified thme-‘Iiycar psymia’cric
residency tminina program at the Institute. and a special training proin clinical psychology is being established. Both in the 133%
and in the training
prom
, the Institute is afﬁliated with
prom
the Departmnt of Psychiatry of
Washingtm Univcmity School of mam.

Wow.

.

a comt

m

At the present time, there am a numer of march
program in
pmgmss. Truce include Lithim a therapy for mania; the use of
Yohiwine as a precipitant of anxiety and the developmnt of antianxiety agents; relation of EEG patterns and orgmic fwtm in the
mammt of Wrap): resistant psychotica; cmtcr analysis of the
electroencephalogr‘m; thc effects of drug withdrmal
on behavior in
the chronically ill; and thc treatment 013 paymcticc by nurse relationship therapy.

a

-

,

�Dr. M. Z. Khan
December 13, 1963

Pam I‘m

for rental or
Wtim are availabletwpomtim

fcn‘

sale within ten

minutes of the institution. While
mom to Marian can-s
not be paid directly,
has been the established policy of the Institute
to increase the salazy by $1,000 in lieu of a dime: paymmt far transportatim. This has the advantam for
who remain with the
Imtituta of providing a higher base salary in subsequent? years.

it

midst”

'

I am enclosing a description of the Irmtitute. If this 0990!»tmﬁty interests you. I muld appreciate a copy of your cﬁwiwlum vitae
listing Magician): your echeatimal and pmfassiaml
In additim, a small photcgmph and the names of at least cadence.
two mfemea
to whom w my write would be most helpful.
Sinoemly yours.
Max

Pink,

Mmctor
MFzmlg

Enc.

M.

D.

�</text>
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                    <text>January 25, l97l
Dr. N. Khazan
Mt. Sinai Hospital
New

York,

New York

Dear Dr. Khazan:

It

was a

pleasure to

visit

your laboratory. and to find so many

believe we may be able to assist you
quantification problems. and support the development
of an EEG quantification facility. He envision four steps:
(l) quantification of the data of your immediate projects.
using a variety of techniques for analysis;
problems of

common

in solving your

a

(2)

EEG

interest.

We

analysis of the data of specific projects, to provide
own data analysis unit;

basis for the development of your

(3) a review of the commercially available equipment
configurations and computer programs for data analysis for your needs;
and,

(4) an application for support. and the development of computer
programs for an analytic system for your laboratory.
For quantification using our IBM 1800 system. you will need an
FM tape recorder compatible with either our 7 channel (l/Z inch tape)
Aopex $9-300 or 4~channel (1/4 inch tape) Hewlett Packard 3960A. Copies
of specifications are attached: note the head configurations, tape speeds
and IRIG FM center frequencies and band widths (at various speeds) if you
1.

elect

a machine of another manufacturer. (He are not pleased with the
300 and suggest you investigate Sangamo or Hewlett Packard for a 7
channel recorder). You will also need an oscillator, similar to H0 202C.

SP

reviewed your usual method of data collection, the samples would
rats, continuous (or piecewise continuous) and the epoch
sizes, arbitrary. For period analysis, we are able to provide epochs of
any size, continuously analyzed, with a statistical output for the changes
after an event (drug administration) from the “resting” samples. If the
sample length is sdfficiently long, we can analyze the experiment at twice
As we

be subdural from l~5

the recording speed. The cost for AoD conversion, period analysis,
paper and card output is sou/hour of computing time.
.r'

war-:rr

“mmwm_w

..

”.115

r

statistics.

�Dr. Khazan

January 25, l97l

~2¢

If the recording and processing of the data are systematic, we are also
able to apply the appropriate multivariate statistics. Our present model is
based on linear regressions, and computer time using the 360/40 is calculated
at SlOOIhour with some pro~processing time at SlO/hour.
As a basis for future
to process the data in
optimal method. He are able to
analysis; to use power spectral

applications and for a defined project. you
variety of ways, to assure yourself of the
vary band widths and epoch sizes for period
density analysis; or to vary the multivariate
statistical approach. You should be aware that we now ore-filter our data.
between the tape and the A-D converter. The frequencies of interest to you
in the rat may differ from the frequencies which have customarily enjoyed
our interest, and you may wish to replicate the analysis of some samples
11.

may wish

one

without

filtering

and

a

at special filter settings.

Such experiments can be undertaken under the same conditions as

(I).

11!. Based on this experience, it should be possible to define your
needs and to canvass the equipment/software markets for the best configuration.
If done today. you should consider the lam loop (and our software) and the
DEC PDP«l2 (software in Philadelphia, St. Louis).
we once considered Control
Data and Scientific (Xerox) Data.Systems). There are additional manufacturers
that may be considered. Each should be canvassed for l97l~72 bids. we could
define your needs as we anticipate them or as they unfold in (I)(II), and obtain
the bids for you. It is important to consider the need for software support
and we can provide estimates for these costs. as well as deliver the programs.

(I!) and (III), we are prepared to assist
for support; and, as “consultants". to
participate in the defense of the application and in the establishment of
the program, including the training of the personnel.

IV. Based on the data of (I)
you in applying to funding sources

—

'

For the program outlined in (I), (II). and (ill) above, the direct
consulting rates are $300/day or $50/hour. A program rate for (l) and (II)
can be set at slSOOIouarter or a specific estimate for a project. For (1V),
the program charge is $4,600.

Rather than a piecemeal approach. you may prefer an annual consulting
and we estimate $6.000 based on our View of your needs.

It will

regards .

be a pleasure to have the opportunity

‘nvl

to assist you.

Our

fee.

best

Sincerely yours.

'wjr'ﬁ'v'c‘rrgtw'twmvlﬂ"

Fink, H.D.
Professor of Psychiatry

Max

w—n-m.

1‘
w

“ma-«“1

A

MFrkt

enc:

Brochure SP 300
Brochure HP 3960
EEG

Profile Analysis~Progress Report l970

Computer/EEG l967

Donald

Shapiro, D.Sc.
Professor of siestatistics
M.

�</text>
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                    <text>._.._ ,_.. .— 'v

rum”... WMw—nwwm

Wyn—w-

,

["__,,

!'—*"m“&gt;v—

www.-

"r

W,

“w.w.
.

,

.

ww""~V-W‘rw 1-ma’

,

~2—

Juno 14, 1971
10:

Dr. Nain Khazan
Mt. Sinai School

of Medicine

1800 Computer

Analysis of

New

For

IBM

York,

New York

EEG

- 3/29, 3/30, 5/5

8

5/5,

1971

(Please lake check payable to the Now Yotk Medical College and send
Max Fink.)

to the attention of Dr.

Wﬁ'ﬂmmm‘

,n—u—w—u—y—

m

MF:kt

$750.00

�</text>
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                    <text>May

12, 1970

Mr. Paul A. Kiefer
Translations Editor
Consultants Bureau/Plenum Press
'

227 West 17th

New

Street

York, New York 10011

Dear Mr. Kiefer:
I have read the translated chapter from Prof. Saarma's book
schizophrenia, with some interest. I also read his own summary,
pp. 164—170. The book reflects the usual Russian approach to
psydhiatric problems, and while he has some data, it is not presented
in fashions we usually understand.
on

The data is interesting, and I believe a translation may
serve to enhance communication. Particularly, if you could
interest one of our Russophiles to write an introductory section
or summary, transliterating the technical terms of the text.
You may wish to consult Dr. Wagner Bridger of the Albert
Einstein College, New York, for his opinion - he is a local
student of these problems.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>7383.- 5518.3

robmry 26th.
To:

shotgun E. Kiutfur, E.D.

FROM:

Max

SUBJECT:

Dr. Eugene L. Lawlnkopf

I

Fink,

1973

M.D.

met Dr. Lowonkoyt

first

when he anus

to

30v York

Radical Cell-so in Hiy'ot 1966. It was clear than, and his
aubauqnant history cantirms, tbs: he is a clinician of «Virago
experience, without particular akilia in adulaiatration,
roaanrch, or teaching. He was t pleasant young man vho
left 32MB Vina faced with the rigors of participating in
controlled aamparisonn of drugs in the outpatient department.
He chose to laavo RYMC rather than wart through a more
satitfhntory working relationship. (I may be doing him nn
inJustice, far I understood than that the Bronx manicipal
was racruiting actively, and thay muy haw» offered hiu a

better position).

I can not see him an an motive participant in any
or the ongoing programs. fbr he in too advanced in yeﬁra ta be
a staff maﬁbcr at the VA or CI; nor does ha haw. enough
taperiancc to sue him an an independent teacher. cansultnnt,
or rtstaroher.

I an.uchadnled ta

Lona Iulnnd

NF/id

university.

31v: a caning: on Mhreh 20th nﬁ
sud can not meet Gene here.

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                    <text>July 7, l969
Dear Prof. Kielhoiz,

letter

of June l8 regarding the l960
to working with you and should
the
like
share
to
origins of this program title. At the
first
Rome meeting of the Program Committee, the subject of amphet—
amine abuse was suggested by one of the European colleagues
and l suggested cannabis abuse—- the two recommendations reflect—
ing the relative importance of the problems in our respective
countries. When the subject of amphetamine and barbiturate
abuse received more votes of the Committee than cannabis, l

Thank you
ClNP symposium.

for your
i

look forward

accepted the decisoon, until one member remarked that a matting
had just been held in ltaiy on the subject of amphetamines. l
had not been to the meeting, nor had anyone at the Program
Committee, but in Liege, l heard the details from Munkvad and
from Jacobson. As it seemed redundant to schedule another
meeting so soon on the same topic, with the same participants
(probably), l urged Dr. Vinar to assign a broader topic to the
section. This title will permit us to provide as broad a
program as we wish.
i look forward to welcoming you in New York in December,
and surely the final plans can wait until then. in the
meanwhile, i would suggest that you write to Gharattlnl to
obtain a copy of his attendees and the titles of their papers.
We may provide an opportunity for one to summarize the
experience with amphetamines over the world, the pharmacolgy
as is now known, and the Japanese and Swedish solutions to the

problem of abuse.

recommendation is still that a more timely and
interesting meeting could be provided about the subject of
cannabis. Many studies are now in progress in the U.S.,
ltaly, Greece, lsrael, West Germany-- there is no shortage
of good, young workers. The material is new, and at a
minimum it should be possible to have 2 halt—day sessions
or even 3. The latest meeting on cannabis was held earlier this
year in London and focussed on the chemistry of the der—
ivatives. i know of no other meeting planned.
My

own

The only question is the relevance of the subject for
European investigators. if they are not now interested, they
will soon be; for with the American talent for marketing,
the European nations will have a cannabis problem very soon-~

if it isn't already there.

if this is not satisfactory, it should be possible to
arrange 3 reports-~ one on amphetamines, one on progress in
barbiturate or opiate therapy, and one on marijuana. Such
a program would be educational and acceptable, but less
novel and less innovative than one focussed on cannabis.
Such a mixture is not publishable, but a symposium on
cannabis may be.
i

in

New

look forward
York.

to

working with you; and

to

welcome you

�</text>
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                    <text>.7.

.AWWNW‘T'mwxg-‘vwrmm‘

December 15, 1969
Dr. P. Kielholz

Psychiatrische Universitatsklinik Basel
Wilhelm-Klein-Strasse 27
4056 Basel, Switzerland

Dear Dr. Kielholz:
The meetings in Mexico City were excellent, and your
participation was missed. I regret that we could not discuss

the

CINP

program, and

this letter will be

a

start in

our plans.

I would suggest that the CINP program should assess
amphetamine abuse, emphasizing the problems of addiction,
withdrawal, secondary effects (psychosis) and cultural
differences. The use of amphetamine as a model for
psychosis and the relations to schizophrenia are less relevant

as these are not significant public health problems.

I would like to see reports on the following subjects:
1. The sociology and clinical pharmacology of
amphetamine abuse in different countries as Japan, Scandinavia,
U.S. and Western Europe.

2. Mechanisms (biochemical, pharmacological) of
amphetamine "addiction“.
3.

Effects of amphetamines

on

sleep or

clinical behavior (dreaming, hallucinations).

some

For these topics I would recommend the following
be invited:

l.

specific

scientists

Amphetamine abuse in U.S.:
”

”

“

H

H

H

”

”

”

John C. Kramer, U.S.
David Smith, U.S.
Scandinavia: Rafaelson, Denmark

Japm:

?

Western Europe:

Connell

�Dr. Kielholz

-2-

December 15, 1969

2.

Mechanisms of Addiction:

Utena, Japan

3.

Effects

Lewis, England
Oswald, England

on

Gunne, Sweden
Friedhoff, U.S.

Sleep:

Dr. Vinar has given me the names of authors and the titles
of abstracts spontaneously submitted to the CINP. Except for the

title

"Pharmakotherapie und Sozialaktivitat
Erfahrungen mit Tages Nachtklinik und Patientenklub” by Helmut Rennert, there is no title
that interests me. I have asked Dr. Vinar to obtain an abstract from
Dr. Rennert for us.
—

I would appreciate your suggestions. I believe we should have
four speakers, allowing an introduction and summation by us, and
discussion by the audience. Since funds for participation in the
CINP from the U.S. are non-existent this year, we should make
every effort to invite American scientists to the invited symposia or there will be no U.S. participation.
I have no deadline from Dr. Vinar but
our invitees and alternates by mid-January.

trust

we

can make up

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

cc:

'

umw.7.""

Maw“;

~21.

gmwwme-Ut

_.

Dr. Vinar

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w“-

”WVW

_.. ,...v-.

November 19, 1969

Dr. P. Kielholz

Psychiatrische Universitatsklinik Basel
Wilhelm-Klein-Strasse 27
4056 Basel, Switzerland
Dear Professor Kielholz:
I am

delighted that

December. I, too, plan
and we should make time
that week.

we will be able to meet early in
to attend the symposium in Mexico City
available during the first part of

I do not plan to be in

I would be

New York on December 5, otherwise
pleased to take advantage of your kind invitation.

I look forward

to seeing

you in Mexico City.

Sincerely yours,

BMthm,Mﬂ.

Professor of Psychiatry

MF:kp

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.

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u-«-—.w1,v~n.=y,...‘.m. w, (1".1.

Novambcr 9, 1969

Prof. Dr. P. Kielholz
Paychiatriache Univcrsitatsklinik Basel
Basel, Switzerland
Daar Prof. Kielholz,

ER‘

I have waited before developing the 1970 program of the
with you, until the many small details aboat tha maeting,
the dates wet: settled; and anticipating your visit to New Yorkspecifically
as
being sufficiant time for us to deveIOp the program.
CIR?

In year

at the beginning of

letter

Daccmber.

you remark

that

you

will be in

Please note that I V111 be away from New York tron
to December 7. Can you givn no a specific time when you
will be in New York for us to meet 7
November 27~29.

perhaps

we

I plan to attand ch: German CIHP 1n Nﬂrenberg from
If it is possible for you to be at the same meeting,

can discuss the program than.
My

best regards.
Sincerely yours,

w

‘rw‘w‘

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Max
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Nani-W

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Fink, M.D.

Professor of Psychiatry

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Novamber 26

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                  <elementText elementTextId="103198">
                    <text>~

.A

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.v

|"

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v
xan:

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,

1970

Psychiatrische Universitatsklinik Basel

Wilhelm-Klein~5trasse 27
4056

Basel, Switzerland

Dear Dr. Kielholz:

Before the holidays I sent the enclosed suggestions
regarding the CINP program. As I have not heard from you
I am taking the liberty of sending you a copy of that letter
and ask

for your

comments.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

,M—

”a...“

.

Dr. P. Kielholz

..,..

va,n.~_q,-w..¢.r

at: “Hum“ m"".~gw—-MMIK&gt;W‘A-—.‘ .nw—«M -,,

January 15,

«Vinwnﬂngnw

4,...V

»

6116.

�</text>
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,,

now

sympwﬁwi.mmmug—ramw-«uww-mu--.. rw'V'r'r' 'v:~r“.wW'-;

'VVI“."Y'V:A&gt;=-I;F:y,...

April l5, l970
Dr. P. Kieihoiz
Psychiafrlsche Universifafsklinik Basel

Wilhelm~Kiein—S+rasse 27
4056 Basel, Swifzeriend
Dear Dr. Kieihoiz:
i

have received various letters from The CiNP Program
my answer To fhe lafesf is enclosed.

Chairman, Dr. Vinar, and

i. The symposium Thai
Tifles lisfed.

has been submiffed

conslsfs of

The

2. The co—symposium is To be made up of submiffed "free
communicaflons". My leffer To Dr. Viner suggesls we could have
all l2 (absfracfs enclosed) bu? would prefer i-8, sugges+ing
9-l2 +0 be presented in The "Free Communicaflons”. The decision
is To be Iefl To Dr. Vinar.
3. He asks The? one of us summarize The proceedings in
fhe Plenary session. Since i am presenfing in fhe symposium,
would if not be eppropriefe for you +0 summarize The sessions?
i

would be delighled To have you do so.

4.

The papers of The symposium and co-symposium may make

find issue of a Journal, and i would ask if you would consider
lhis for your Journal, Pharmakopsychiafrle? (incideniaily, your

a

leffer of February

9 was

nof clear whefher you did indeed wish
a subsequenf issue of

reporf on anfegonisfs and mefhadone for
Pharmakopsychiafrie.)
a

I

look forward To our working fogefher in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
Mszp

w

-

“luv-«.m- urn-.m-

mawwu-M'v

*1

�</text>
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"W ,-

——w ———~~-r»

'vw‘

w .._- -

w“,warm...“
,,

..

.W

w- . w-n

——

,

June 2, 1970

Prof. Dr. P. Kielholz
Peychiatrieahe Universitateklinik Basel
switaerland
Dear Dr. Kielholz,
Thank you for your letter of’May 28. I am sorry that
misunderstood
the program outline. I have invited Dr. Ladewig
you

to present during the symposium, on the topic of‘VAmphetamine

and Hallucinogen Dependence in Europe", as a joint presentation
with Dr. Battegay. I wrote to him on May 25, extending the formal
invitation of the Program Committee chairman, Dr. Vinar. By now,
he should have received the

invitation.

to Dr. Vinar indioating your acceptance
I will write
and co—sympoeium
to summarize the

of’the responsibility

at the Plenary session.

with you.

I

symposium

look forward to seeing you in Prague and working

Sincerely yours,
Fink, M. D.
ProfEBeor of.Peyohiatry
Max

me

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                    <text>,m»

29 September 1973

Jiri

Roubicek
Experimental Therapeutics Department
Sanloz Ltd.
Dr.

Basie, Switzerland
Dear

Jiri,

It was a great pleasure to be able to attend so many of the
meetings in Marseille with you, particularly the many discussions which
fOllowid the presentations in our common session. As a chairman, I
very much appreciated not only the content and the spirit of your
remarks, but your willingness to lead the discussion. I found the
meetings most helpful and interesting, and I look forward to continue
the discussions in your laboratories.
I received the enclosed letter from Professor Kielholz. I
at the GIMP committee meetings in Beerse before Marseille, and
in exchanging pleasantries indicated that I would be visiting Basle
in October. I am also enclosing my reply-- trusting that you.can make

met him

arrangements which are diplomatic and acceptable to you.

family has discussed the forthcoming trip often. Neither
free to come with me, but Linda, my youngest
me. Because I wanted to allow her some freecome
with
will
daughter
dom, I am also bringing along my nephew, and so I will have two youngsters with me. I would be grateful if you would arrange fOr two rooms
for the two nights. In checking my travel arrangements, I am scheduled
to leave for Amsterdam Friday morning at 10:30.
My

Martha nor Rachel are

regards.

I look forward to visiting with

you and Marcia.

My

best

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

amen v

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                    <text>February

l.

l970

Professor Paul Kielholz
Editor. Phareekopsychiatrie
Basel, Switzerland
Dear Dr. Kielholz.
I have

just received your letter regarding

a

report

on “Methadone Maintenance Treatment" for the special issue on
Drug Dependence of Phereekopsychiatrie. This was addredsed to
Bellevue Hospital and was not received until yesterday.

pleased to contribute to such a volume,
be broadened to the general topic
of pharmacologicll treatment of opiate dependence. To review the
use of methadone alone is too restricted. since we have more ex~
perience with cyclazocine and naloxone. A description of these
three approaches. as we now use them. and as we propose to use
them in our future prograns. may be more useful than one devoted
to methadone alone.
provided

I would be

that the subject could

If,

however. someone else is already covering the

antagonists. then perhaps

he would be
methadone treatment as well.

willing to report

on the

It is not possible to meet the deadline of January 31,
l970; since that is the day I received the letter of invitation.
The report could be written during the first two weeks of March and
sent about March 2i, at the earliest.
which I

I thank you

also for the answer to the

will respond to in the next

few days.

CINP

program.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>March

i0, l970

Dr. P. Kleiholz

Psychiairlsche Unlvsrsifniskllnik Basel

Wilhelm-Kisin-Sfrasso 27
4056 Basel, Swifzoriand
Dear Dr. Kielholz:
Some

offend.

i

of the

earlier suggesfed parflclpanfs

have sea?

The second round of

were unable +0

invifafldns.

Dr. John Griffifh accspfs, he will presen? his data on
amphefamlne abuse in The U.S. Your observafions, on drug abuse
in EurOpe, should be a logical accompaniment of this dais. either
as discussion or as a confrssllng (parallel?) reporl. Would you
please send me a fills and a lOO-iSO word abstracf, as soon as

if

pracflcabie?
As

soon as the various

immediafsiy.

invitees

have agread,

i

will write

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychialry
Mszp
one .

�</text>
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                    <text>.v;...._~n-..

,

31,“.

A;.A-r~._v,._

my.

April l5, 1970
Dr. P. Kielnolz
Psychialrlsche Universllafsklinlk Basel

Wilhelm~Kleln«Slresse 27
4056 Basel, Swiizerlend

Dear Dr. Kieiholz:
have received various lefTers from fhe CiMP Program
Chairman, Dr. Vinar, and my answer To The lalesl is enclosed.
l

l.

The symposium The? has been submifled

filles lisfed.

conslsfs of fhe

2. The co-symposlum is fo be made up of submiffed "free
communicallons“. My leiier to Dr. Viner suggesfs we could have
all l2 (absfracfs enclosed) bul would prefer l—8, suggesfing
9~l2 #0 be presenfed in The "Free Communicelions“. The decision
is To be leff To Dr. Vinar.
asks That one of us summarize fhe proceedings in
The Plenary session. Since i am presenfing in fhe symposium,
3.

He

would if no? he appropriefe for you lo summarize ihe sessions?
i would be delighled To have you do so.
a

find

The papers of the Symposium and co—symposium may make
issue of a journal, and i would ask if you would consider

4.

This for your journal, Pharmakopsychlefrle? (lncidenlelly, your
leffer of February 9 was no? clear whelher you did indeed wishof
a reporf on anfagonlsfs and meihedone for a subsequenf issue

Pharmakopsychiefrie.)
i

look forward

to our

working Together in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychielry
Mszp

�</text>
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                    <text>-—

nﬁ‘

.

'

"walniwimmwrvmamwmw,Mmm‘n'.

,

June 2, 1970
P. Kielholz
Psychiatrische Universitatsklinik Basel

Prof..Dr.
-

switserland

nWJ-wmlv-V'

Dear Dr. Kielholz,
v‘rlrmw.V'-Mlﬂnlww"rl“uqx—.

Thank you for your letter 01‘2“le 28. I am sorry that
have invited Dr. Ladewig
you misunderstood the program outline.
to present during the symposium, on the topic of “Amphetamine
and Hallucinogen Dependence in Europe", as a joint presentation
with Dr. Battegay. I wrote to him on May 25, extending the formal
invitation of the Program Committee chairman, Dr. Vinar. By now,
he should have received the invitation.

I

xm'm'm

um

.

Wynn-r.

um

n
«Ir-v

vmmm:

to Dr. Vinar indicating your acceptance
I will write summarize
the symposium and co—symposium
to
the
responsibility
of
the
session.
Plenary
at
with you.

I

look forward to seeing you in Prague and working

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
"#7

.

�</text>
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                    <text>December 26th, 1972

Paul Kielholz, M. D.,
Psychiatric Clinic of the Univnrsity.
Basel, Switzerland.
Dear Paul,

I vary

much enjoyed

and your anthusinsm made
5 manordble one.
‘Aa wo

are

now

our discussions in sun Juan.
Swiss Chalet

the dinnar at tha

preparing a study

at acute

withdrawal

in cannabis. I read your comments to the WHO in 1971 and
in the 1970 issue of Dautacha Meﬁizinisehe Wbchanschrift
(95z'101s105). The paragraph on vithdruwnl (pg lab) is
must interesting.' Have you a more detailed aescription
of the behavior of the subjects during withérawal that
you may make available to me?
’

In chacking for tha 1972

WHO

repert, I find

it it

not yet available in
York. should there he data
or coamsnta from that meating that are relavnnt to our
interest, I vonld be neat grateful for your making these
uvaildble ta no.
Kew

My

best wishan for a

happy ana propperoun 1973.

Sincerely yours.

M33

Fink.

M.D.

9rofessor of Psychiatry

HF/iJ

&lt;

n.

t.

4941-,“

�</text>
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                    <text>7&amp;83w04983
1 February 197‘

x. E. Sting. Blanca:
ﬂaw Dinnnoionn

Backnnn Instrununta. Ina.
2500 Harbor Boulcvnrd
tullcrton, California 92634

Dear Mr.

Stine:

I would 11k. to tats advantasc of your 15-day frat trial
offar for BEG~1, "Eleatronicu for EEG Tachnicinnn.“ Hi can
wait for it the 60 days, when you anticipate it will be available.
Thank you.

Sinethly yours.
Fink. M.D.
Professor cf Psychiatry

Max

MI/cis

�</text>
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                    <text>November 1n, 1979

E. Kielkopf, Chief
Contract Review Unit
Ms. Mary

NIDA

5600

Fishers Lane

Rockvﬁlle,

ND

Dear Ms. Kielkopf,

I am willing to participate in the NIDA contract review
I
enclose
system.
a short resume which highlights my professional
experience, oaitting the publication list which is a bit long. My
publications in drug abuse encompass the long term effects of cannabis,
narcotic antagonists, EEG effects of opioide and antagonists, methadone
and levomethadyl therapy, among others.
Thank you

for the invitation.
Sincerely,yours,
‘ﬂé:§¢”ﬁﬁiﬁlﬁr

Pink, M.D.
Professor of Psychiatry
Max

�</text>
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Sewn...“

.w

W

wag-WW...-

m

”mum-aw.

wwmw

V,

.

December 29. 1967

Mr. M. Kietzman

Biometrics Research
722 wast 168 Street

New

York, ﬂew York I0032

Bear Mr. Kietmaan:
Thank you very much for your letter of invitation and
the program of the Biometric Research Workshop, to be heid
February I3~IS. Whiie I wouid Iike very much to attend this
conference, I find that I have aIready accepted another
invitation to participate in a program in Europe. In the
event that I am unabie to make that trip, I wiII caII and
confirm my attendance.

Thank you once again

for your kind invitation.
Sincereiy yours;
Max

Fink, EH}.

Professor of Psychiatry

Mszp

�</text>
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                    <text>vrvp-n-uwv

August 9. 1953

Mr. Joseph H.

Kim

Advisory Off-51m

and Amuity Association
mam
1mm
of Marina

739

W17,W

H. Y.

How Yaw]:

Dear Mr.

Kim:

Wed m TIA/HIRE? applications for tho follwing:
motor,
D...

Max

Pink 24. 13..

Sam

Gamma,

”hm I

Missouri Institute of Psychiatry

W

Wipe}. Ramamh Scientist,

Institute of Pay.
Scientist, Ho. Institute of Pay.
$01 Garfield, PhD. ,Pvimipal March Scientist, Mes. Institute of Pay.
Aim
of Missouri and: #800
is Psyomatric Research
32
$583.
in the mat of
July 13mm for t)» abovu lacimtiats;
a.
List
md copy of the Fundatim's £231:th
a Praia

,N.

mm

H. D...

Mum

Principal

WW

Ho.

mm

Emulation“.

If than an

my quaatims, please mutant

m.

‘7)

Wisely.

Sincerely

yam.

nu Fink.

a; n.

'Emwtivu

ﬁrm:

mu

Dim

mm- you.

�</text>
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                    <text>Fobruoty 17, 1964
Dr. Keith F. Killsn, Jr.
Associate Professor of Phsrmscology
Stanford University School of Modiclno
Doportnonc of Pharmacology

stsnford Medical Center
300 Pastour Drive
Polo Alto, California

Dear Koltht
Your summary of the ACE? meeting was very good, and
on to Dr. Rothnnn.
tent

it

I have

pages. in which you outlined
the gonorol discussion. Also, I must congratulate you on
your smty of tho prountstlou by Dr. R’. H. Smith.

I

most enjoyed the

My

lost

{ow

best regards.
Sincerely.
Pink,
Director
Max

HF/jh

M.D.

�</text>
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                    <text>STATE UNIVERSITY

05 NEW YORK AT

Health Sciences Center

-

srom

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

,

Laboratory

'

_

,

December 23, 1976

Keith F. Killam, _Ph.D.
Department of Pharmacology
School of Medicine
University of CalifOrnia - Davis
Davis, California 95616

Dear Keith:

Mindful of your comments at the ACNP meeting
in New Orleans, I am writing to ask for a list of citations
(and copies of the reprints if available) describing your
studies of psychoactive drug effects in simians.
The meeting was a good one, and you

are to be con-

gratulated in successfully weathering the stormy
an

officer of
My

ACNP.

voyage as

thanks and best.wishes for a healthy 1977.

Sincerely,

M

MF:fg

Max Fink, M.D.
Professor of Psychiatry

�</text>
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Wham;
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mmmmmmmm,mm

mmmummwwmmg.mmm
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                    <text>camber 25. 1983

DP.

hit)!

1".

Kim

Mimity
School of mdicim
Stanford

Department of Plnrmoolow
308 Paateur Drive

Wank

Pale Alta.

mum:

PW

Imtakingthisoppmmtytawadywacopyofa

mpwt regarding the instrumentation Moped during
the past few months in his laboratory.

Imaorrythatymdidwthawmopporumityto

Mitwiﬁmmmringymmtdp

.St.mms,bwtlodtfm-

Mtnmopmmitytodism Iminmaurdctailin

“Wm.

'

Sincerely yours,
Fink, H.
m
Mm‘cw

Hrs-ls

Emmi.

D.

�</text>
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                    <text>54%

u‘V

December 16, 1963

W WW

Dc. Keith

Kilian
of W103)!

Stmfwd mimity School
300 Pasteur Drive
Palo Alto,

a:

mm
.

Dear Keith:

Inmadingﬂu,mpmminmtm,lﬂndﬂmtourmimia
Irawamadymtifiad m.
atmdaym,Jum16thm17th.
Stemmdmaboutmpmﬂbilityofbemginusaimfwm
days.

phase indicate? this to our other invited mats?
indium that we are “dime!”
that the
I alas
this limitation is an
believe
{our guests for maultmts. I
Would you

m

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Ithinkwoamulddismgmthis.
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Hy

beat

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MFwM

cm W. Jim Town

812ml);

m,

m
m, M. D.
Director

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-

n

:er-tl’wvo—r‘v—y

w..77¢

"w

u.

way

v—rxuru-e

'wwwc

,r.

Im

January 30, 1979
Dr. L.C. Kiloh
School of Psychiatry
University of New South Wales

Little

Bay,

Australia

Dear Dr. Kiloh,
Thank you for sending me the review, "ECT:Its Place
and Value in Present Day Psychiatry". I found
thorough and detailed,
and congratulate you on the effort. While I agree with most of what

it

is included, including the conclusions, there is

our understanding of the mode of action.

.

7mm,

mpg“!

,

.

a,

some

question about

It seems to me that one can deduce much about the efficacy
of convulsive therapy from the information in your review—~ notably
the
importance of the bilateral central seizure, the equivalence of inductions,
the need for multiple seizures, the predictors of outcome, the diagnostic
classes which respond, and the neurophysiological evidence of the importance of bilateral EEG changes in the adsessment of efficacy. From these
-observations, it seems to me that there must be an influence on some
centrencephalic structure, an influence which is expressed after a
number of seizures, and therefore in the persistent biochemical
changes.

It has been the influence of the neuroendocrinologists that
suggests the next step in the process. The neuroendocrine changes which
mark endogenous depression have been defined in part; and in your
excellent review of the predictors of ECT, you noted that the vegetative
symptoms are the best predictors of ECT outcome. These observations,
plus the notes on changes in calcium metabolism and the btood brain
barrier have led me (and others, as Jan Otto Ottosson) to define the
present view of the mode of action of convulsive therapy in terms of the
hypothalamic effects. Surely, in relation to our knowledge of the mode of
action of other psychiatric therapies, we are farther along in convulsive
therapy, and a ummary of your views is the only omission in your report

which I missed.

other question of persistent concern is the role of
It is not clear from the literature whether such treatments
are effective, for whom, and at what rates. Their role should be clarified
One

maintenance ECT.

�”an?”

-2in the review.
I am acquainted with most of the citations but that of
Osselton which you cite as personal communication, 1978. I would be
grateful if this report is published, if you will let me know the

citation.

work on the Task Force and the reviews which you
volume which will be published
by Raven Press next month. In "Convulsive Therapy: Theory and Practice",
I expanded on the theoretic background of the process and (hopefully)

cite led

My

me

to expand the reports into a

present a cogent theory of

mode

of action which is quite testable.

to Graham Burrows in Vienna, I had hoped it
to Australia this year, and I had hoped to
visit with you. That seems unfeasible at this time. Should you be
coming to the States, let me know and I will be pleased to arrange
for you to visit us, to discuss this and other similar issues.
Thank you again for sending the preprint. I look forward
to its publication.

would be

When-I spoke

possible to

come

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>mu'mmv"'ﬁl‘

n-u

"Yr-1r"

-&lt;

«nnm-

“w..."—

v...

T

'nr-ng’wv-

w,—

”I“;

.Z'NWJW'I

z-rwvjv'

s-‘fa‘wwﬁw-"r

ll»

Hovenber 4, 1971

Dr. Lester
Editor

King

Jﬂml

535 North Dearborn Street
Chicago, Illinois 60610
Dear

Sir:

We are pleased to submit the report, "1~Alpha~Acetylemethadol
in Haintenence Treatment of Opiate Dependence“ for your consideration
for the Journal.

This etudy deacribee similar clinical reeulte for l-alphaacetylenethedol given three tines a week to daily methadone. Should
this prove generally applicable, the saving in illicit methadone and
its coneequencee can be great.
Thank you

for your consideration.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Hex

erig
Enc
e

�</text>
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                    <text>November 4, 1971

Dr. Lester King
Editor
.EMA

535 North Dearborn Street
Chicago, Illinois 60610

Sir:

Dear

We

are pleased to submit the report, "l—Alpha—Acetylemethadol
Dependence" for your consideration

in Maintenance Treatment of Opiate
for the Journal.

This study describes similar clinical results for l—slphaacetylemethadol given three times a week to daily methadone. Should
this prove generally applicable, the saving in illicit methadone and

its

consequences can be great.
Thank you

for your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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,

‘m ;u~.-.

,

November 16, 1970

Dr. Lester S. King
American medical Association
535 North Dearborn

Chicago.

Illinois

Street

60610

Dear Dr. King:
Thank you for your consideration of our brief report
on naloxone treatment. We are enclosing an 80 word synopsis

for this article.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry'

Max

MF:kt

,
.

F.’

T'm'v'r/E'uj?‘

�</text>
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                    <text>October 30, 1970
Dr. Lester S. King
American Medical Association
535 N. Dcarborn

Chicago,

Street

Illinois

60610

Dear Dr. King:
We are resubmitting our revised draft of "Naloxone Treatment
of Opiate Dependence: A Progress Report", for your consideration
for the J.A.M.A. Your suggestions were excellent, and we have

adopted each one.

Again, our thanks for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>cruv7-(w“wgwuv—‘IWVVWV‘VL""‘V~WWW;'q-mv—wvv&gt;r.)wﬂ~snwv|wlw
m

A».-

,
i
v . v m.“4. WWW”.
1.4:. w m -7...
.. ”“7
w~,.~.qv._mnwr.:.m
rw
-

-

v

.

.‘

‘ww..-

1n:

*ﬂ‘)‘

my.

‘

_r7"

February 2h, 1975
Buoy Jane King, M. D.
Virginia Commonwealth

university

Medical College of Virginia

MCV

Station
Virginia

Richmond

23298

Dear Luyy:
Thank you

for your kind remarks.

unilateral electrodes,

Pa. , 191mb)

with one of

When we

needed

obtained them from Medctnft (Skippack,
and in 1969, they were catdog No. 1031 and cost $18.00.
we

interested in a working document that I edited
co~workers at that time for our residents. Although
dated (June 1969) I think it is satisfactory for your

You may be
my

it is slightly
library.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

Enol.

�</text>
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Dr. V.

J. Harms-Wright

D Andaman Blvd.
Houston 25, Teams

1200 H

Dear John:

Irmdametploasantviaitwiﬂnymmqmlouaoopy

ofﬂuintaﬂmmportdﬁehlfiladwiﬁxk.€oluamm

hummybammrsoffwt,md,ifoo,
Itnmtthaycanbemetadatmlatwdate.
Osmium.

My thanks for your courtesy.
Swami)! yours,
Max

11th
mo

Pink.

Dimmer

M. D.

�</text>
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                    <text>PSYCHIATRIC RESEARCH FOUNDATION OF MISSOURI

March 18,.

3.96%

Kintomu Air Service

mm Wilding. lat Floor

mum:

is. Mficate of eligibility
Mn:
EM

of
Visitor's 3mm PM :8? 66 on behalf
of Dr. Takumd. 1km. We m sanding thia to you
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H. D.

.

�</text>
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                    <text>“W...”

We.

,~

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,

V

V

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.

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,

‘

y

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vane—ow 3'53!“va ~_-.mwrs+ ~ A.»

V

,

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7

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i

February 8, 1972
Ms. Judith Kiolbassa
Copy Editing Supervisor

AMA

Chicago,

Illinois

Dear Miss Kiolbassa,

Enclosed is the typescript copy of article 0658 for
the Archives general Psychiatry, and my notes on the text. The
handwritten notes are sufficiently clear, and refer to the text
pages. Please add the additional reference.
Thank you

for your assistance.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

.

-

,

"""-“““ W “F ““'“""' V -

�</text>
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                    <text>NOW!“ 5.
Judith

M.

1965

Kiolbasse

American Medioal Amooiatim
535 North Demon: Street
mioago, Illinois 60610

Dear ﬂies Kiolbaose:

ﬂuenkyouverymforyotmletterofﬂovenberz.

shelltrytomreadxiteminseqmoe.
The article title is satisfactory, «mum I
need "A

ow

ohwld
Hospitals." The

word

I

think the

Report of Treatment in Three Voluntary

"mama“ mo

"Wt" are Mainly

inteMmgeable, but in this instmoe, I think the singular
tom is mfembln. However, boﬂx are acceptable.

Wiletlnaddmss

atmemofﬁwartioleismthat

will be used for e long~tem basis, I would prefer that
dung: this for Dr. Kahn, and that is the Department of
Psychiatry, University of Chicago, Chicago.

you

Illinois.

included the name of Dr. Hex Pollack.
dam at Hillside, Dr. Foiled: was a ooparticipant. In this study he was one of the three people
who visited each of the institutions. Hmever, in writing
this report, there were some disagreements as to the omclusions,

In

”the adomwledgement

all the studies

mammotedmttobeaoo-euthorofmstudy.

My

associates and I, wmld, however, like to indicate his
assiotmoe, and for this reason, I think an statemnt, "The
cooperation of Dr.
would be

Max

appropriate.

Pollack

Wully admowledged"

is

memmbemdmfmoesmm.1emaasming

that the Jamaal limits the mmber of authors to three, and
that this is thereason why that intwooftm citetims
the oo-anﬁm om omitted. If this is not a general rule,
pnrhapo in this instance the oo-autlm could be listed.
(31 page 1a, in «Mition to the notation regarding the cooperation
of Dr. Follack, wwld you please change the mamas of Dr. mm

from Hontifiom Hospital to: Depmtmnt of Psychiatry, University
of Chicago, Gaioago, Illinois.
‘

�Miss Kiolbessa

.42..

‘

Also, the dates 1959-196? , which follow the statement concerning
the origin of the study, are inexplicable by memelves. In our
original report, we used the sentmoe, "This study was done when
themzthorewemmocietedetthenepertmtofmtal
Psychiatry, Hillside Hospital, 1959—1962." If some full sentmoe
_

ofﬁaiskindismttobeimluded,thenlwouldemstthat
dates 1959—4962 he

the

mitted.

I

text emfully, and find two small comctiam
thmmgzthe rumor S, and this may be melon to

have read the

Mmlhwamrked. mpephneerthebottan, thewmcticns
slash line
put a

It should read

the printer.

"the California F Scale. 00,5)

mamas VenouldbenmberS,
mmm,
this copy.

mdxmmso

marked

is a table, and were in a symbol whim I do not
mdemtmd. In the first m1mn."omaplete remissim”is split
with a synbol which to m-would indicate that the
"mmissim"
ahmld be mder "couple .“ If mat is 50, win my be unclear.
I do not lmow how this will be set, but ”emplete remissim,"
immd," "moderately inpmd" are each word pairs
that should not be split. If this is too long for the calm,
Page 19

m

"may

then

I

hope
by

together

ya: will indium ”that "nnrhedly improved” fit
appropriate spacing.

.

'Iﬁis is the first time that I have had the oppommity to
edit a Emmet-in in this fashion, and I must say that I found

it quite helpful.

-mmkyaufortheopportmitytoworkwithym, audit

look forward to the final results.

Sincerely yours ,
Pink, PM).
Professor of Psychiatry

Mex

Efﬁe:

.

�</text>
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                    <text>January 2h, 1979
Mr. James

Kipfer

Mental Health Association in Michigan
Lathrup Village, Michigan
Dear Hr. Kipfer,

I am pleased to write this letter on behalf of
Dr. Richard Abrams who is being considered for the
position of
Chairman, wayne State University Department of Psychiatry.

I met Dr. Abrams when he returned from
service
to complete his psychiatric residency training at thehisNewmilitary
York Medical
College in 1966. Based on his experience with ECT in the Army, we
designed a study of ECT which was funded by the NIMH and which was
done at the Gracie Square Hospital. The work was done between 1967
and
1972. During that time, Dr. Abrams completed his residency with
distinction, and Joined our staff as a staff psychiatrist. In
rapid progression, he became the chief of the inapatient unit at
Metropolitan Hospital, and then moved to Stony Brook where he directed
the University service at Central Islip Psychiatric Center. In 1976,
he moved to the Chicago Medical School with Dr. Michael
Taylor.
is an outstanding clinician, researcher and
work has been innovative and with Dr. Taylor,
they have challenged some of the diagnostic concepts which have been
{current for a number of decades. Their work on the identification of
/ mania, catatonia and bipolar disease is exemplary.
~teaeher. His

Dr. Abrams

clinical

In his teaching, Dr. Abrams has shown excellent skills,
particulary in encouraging resdients to undertake research projects.
A record is seen in the
long list of publications which he has with
Junior personnel. Another evidence has been his rapid rise in academic
grade, from assistant professor, 1971-197h, associate 197h-1976 and

progessor since d976.

In his research, he has exhibited skill and a
of the literature. His work in convulsive therapy,thorough
in directing
the ECT studies under MB 15561, has resulted in many publications,
particularly regarding the efficacy of unilateral and multiple ECT,
the changes in EEG and biochemical parameters, and effects
on memory.
knowledge

�-2.
His

Joint efforts in psychopathology with Dr. Taylor have already
to, and it is in this effort that he has shown excellent

been alluded

skills.

Finally, his administrative experience also encourages
his consideration for the position of leadership. At the time that
he took the position of director of the University Service at
Central Islip Psychiatric Center, the unit was little more than a
back ward in a primitive state hospital. By the expenditure of
much effort and travail, he impaoved the staffing, trained personnel,
obtained the support of the adminsitration, and with the aid of the
resdlents, developed a fine teaching unit, which served to treat
patients and as a source of publications and research. (It is fair
to say that his successors have been unable to maintain the high stand—
ard of academic excellence which he established.)

It is clear that

Dr. Abrams has

the academic, clinical

research experience to undertake the position of chairman at wayne
State University in psychiatry, and I recommend him highLy.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

and

�</text>
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                    <text>Septcnbor 11, 1964

Dr. Neil Kiremitci

Blue Kooperatifi Evleri
Blok 1 No. 20
Zincirlikuyu Cad. l Lavanc
Istanbul, Turkey
Dear Rafi:

After leaving Turkey, I continued to have the most enjoyable
vacation. The meetings in England were quite good and it
was a great pleasure to be with my friends Turan and Ellen
once again. I discussed your questions with Turtn and crust
that he has had an opportunity to meet with you.

I express

my

thanks once again for your

dnlicious Turkish dinner.
Good luck on your

hospitality

ozlninacionsl
Sincerely yours,
Fink,
Director
Max

Hiljb‘

M.D.

and most'

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                    <text>§

5'

hhmuy 8.
hr.

01m

1965

Hunted. um.
at:
inoperauﬂ Evloﬂ

Blot 1 lb. 20
Zinclrlikuyu end.

Istanbul,

Turkey

1

Lthnt

mar Butt:
for your taunt lotto: and mllutlon to work in
Dr. tell and I would be pleased to have you
laboratories.
than
v5.11
nuke a fetal punctuation to th: Dan at
join our staff. I
tho Mind School. 113:: u soon
you write telling us whim you
would like to can, and that you haw sucaufully complaint! thl
new examination. I an no: c101: at to what. the problu ha boon
Thank you

a

la ”stunting tor the mat Mutton. but I cnlltd tho 0211c”
1n Mutton. and thcy mama that you an rosin-rad for the

am. Good luck in your oxalmtlon'.
As cm
I he.” a lunar of ”poignant for you. 1!: V111
a
«at on. ”unifying an... salary. are. I look found to
ﬂy
late this
this

latch
b.

hula; you join a
renta- to your wife.

spring or

urly

tumor.

smartly

mm:
P. S.

but

yours.

rink, Md).
m
Profane: of Fuycblatry
Nguld you please send me a photo~oopy of your
dlplom from Istanbul lhivemity, 1953?

mdical

i

5:

1

�</text>
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                    <text>Batch 5. 1965
3:11 Kirnnitci. 3.3.
Ulus Koapcratili Bvlort
310k 1 Kb. 20

Zincirlikuyu Cad.

lutlnbul.

Turkey

1

Levant

boar Raft:
Soon after I wrote on lbbtuary 8th. I racounlndad your appaintnnnt ta thc Departmont of Psychistry.
The Chairman eallcd yesterday :9
:- that the
univnraity nuthoritiaa have :nvicwnd your credentials 1nd
huvn apprnvad your appointunnt to the Depsrtmcnt of

till

Psychiatry. snbjcct to tho anti-tactory couplatiou of tha
BCIMB axlninatian. The inleiul appointment for paych1-'

ntrtltu not holding thq American

Board or

its

aquivalent

nus: b. at tho [oval of Instructor. Envovur. if you are
willing to nah: the A-nriccn Psychiatrie Boards, 1 ba11¢v¢ the Chairman can assure you of an early promotion
to tha lovol of Lactatant Protector as soon as that

etttiltcato is achiaved.

w» are now in the midst of reviawing tha salary
lovnls for psychiatrists with ycur expoticncn. and I
buliavu x can uncut. you that tho in1t1;1 salury V111 be
at a utninun of $16,000 pt: year. although I an opttnaltie
thlt this starting salary may bu «hanged by July 1.

Good luck on your

craminationa.

Stncczily routs,
H‘s

rink. H.B.

Profaunor of Payehincry

ital.

�</text>
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                    <text>2:
A

'-:;&gt;‘"-‘

7».

-v-'

—v.

:.-,-;-—.n-

;7

warmer-gr:-

September 28. l967
Dr. Nafi Kiremitci
8396 Big Bend Boulevard

webster Groves. Missouri 63ll9
.

Rafi.

Dear

discussed your request Iith our chainsan, and
at the present time to make an additional
appointment within this department.
I have

it not possible
‘

it

you requested. I have made a number of calls on your
behalf and I believe that an appointment may be available at
the New Jersey State Hospital at Marlboro under the supervision
of Dr. R. P. Henna. He has an extensive research program under
development and is seeking an aggressive research leader. The
programs are affiliated with the new programs at Rutgers
University Medical School! I have written to Dr. Memo on your
behalf and suggest you contact him. Some data on the hoSpital
follows.
As

My

regards to Betty.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr.

Itil

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                    <text>February 8, l968
Dr. Nafi Kiremitci

Jersey State Hospital
New Jersey 07746

The new

Marlboro,

Dear Rafi,

for

Enclosed are some reprints and a proposed protocol

of clopenthixal. Enough
to satisfy our initial interest, but
study is indicated.
a study

I

will call

March 5.
My

you when I

work has been done
a comparison, long term

return from Istanbul, about

best to Betty.
Sincerely yours,
Max

Fink,

M.U.

Professor of Psychiatry

Mszp

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center. - School of Medicine
o-

I)cpartmént of Psychiatry

Stony Brook, N. Y. 11794
Phone: 516-444-2413

and
Behavioral Science

June 8, 1977

Kirkman Labs

Portland

Oregon 97208
Gentlemen:
Dr. Blachly

EST.

of

it

recently demonstrated

for

a Bite Blok

I would appreciate a description and price

list

and any other aids for EST you may produce.

Sincerely,
Max

Fink,

Professor
MF:fg

M.D.

�</text>
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                    <text>March 10, 1971

Dr. Jay P. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in opiate addiction.

Sincerely yours,
Max

Fink ,

M.D .

Professor of Psychiatry

Mszt
enc.

�</text>
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\l—I“F7ww1\ ..-.‘

V»

..

w...

m

March 10, 1971

”3-w-

*-u'vrtv_4

vw-r—v:w,n-:gw~w~

Dr. Jay F. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in Opiate addiction.

Sincerely yours,
Max

Fink, “.0.

Professor of Psychiatry

MF:kt
GDC .

�</text>
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                    <text>October 20, 1965

Dr. Join

W.

maul

Sac-tiara madam

Mud

Hemmlm

Jansen Rueamh Gunter

Evmvnls, Indiana
Dear D17. Kilﬂl:

$7721

Myanvexymdlformndixmmtminfomﬁmm
fomd this
intemtmg,

your mtimolimrgic commands.

I

very

especially the descrip‘tim of m mas-1. Your mmdatim
that it be tried m antidapmssmt is m intensting one
and has

a

this been assessed?

Incidnntnny, Dr. Votava has publiaMd a report in a
Polish Journal (Pabtzpy Rising I Medgaguy 0Mméadczdncj,
196%, 18, 925), 011:1th "New Colour: of the Anticholinergic
Machmism of the Actim of. Antidapmssmt Thymelcptic Drug ."
in this article which
He describes a umber of mm
and
mtidepmssam' activity.
he claims have both mtidlolimrgic

W

As I Wanted to ya: in response to your first letter,
I an interested in mamas-Ina with Dr. witchell a possible
study ofM-IISB'I. Sofarhehasnotomtamdmm‘sdlm
takingthia oppommity toaskywtohmhimmllmm.

Sinoemly yours .
Pink, ”.13.
Professor af Psychiatry

Max

ORG.

�</text>
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                    <text>5s

Decanber 22 , 1966

Professor Heinrich Klﬁver
Professor of Psychology
Division of Biological Sciences
University of Chicago
amicago,

Illinois

60637

Dear Professor nuver:

It

was

a great pleasure to hear your presentatim at the

American College of Nemopsychoﬂmmcology and your acceptance

ofmenbershiphonoredus. Iwaspleasedtohavehaden

opportunity to review one of your papers and, following our
discussion, an sending you some reprint copies as these were

sent

by

the journal.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>bomber

22 , 1966

Moscow Heinrich mﬁver
mecasor of Psychology

Division of Biological Sciences
University of Chicago
Chicago:

Illinois

60637

Dear Professor ﬂavor:

Itwasagmatplcmtotnaryumpmmtatimattm
AmericanCoﬂegechunopaydchgarﬂyamwceptm
cfmanbershipmedus. Implmedtoravehadan
tytcmviwoneofyoxmpapemmd,followmgmm
discussion,amsendingycuoommprintcopieaasﬂnoem

sentbythejourml.

.

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 10, 1976

Dr. Lannnrt Klaus

KunsshﬁsIVngn 9
I~260 lh GlumslSv
Sweden

Dear Dr. Klaus,
and

Your

letter of

Just forwarded

to

me

23 Dooembur VI! sent

to

my

former University,

- I regret tho delay in replying.

Following our work on oyelazocine and naloxone, as referred
the U.8. Government actively supported the developmznt of
1971,
in
to
new
antagonist, noltrexnno. This ﬁrm; ho: had uxtonsivo clinical
a
antagonists. Clinical trials
triols, and now seen: superior to earlier
and
the
drug is not yet marketed.
under
auxpioos,
research
are still

laboratories which tested the antagonists found their
difficult. When patients have the choice between methadone or
naltrcxonc. thqy surely prefer mathadone. I bolieve that in N.Y., only
my {armor co~worker. Dr. Riohard Rounick in actively using naltrexone.
He reports good clinical results.
I do not believe thot nnltrexone will be very successful,
especially when it oontinuon to compote with nothadono.
use too

Most

Thank you

for your inquiry.
Binoerely yours,
Max

Fink,

M.D.

Profelsor of Psychiatry

�</text>
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                    <text>Febnnry 9,

Emmy 103mm
g.ecu-1m
Enginering. Dept.

mu Wt
St. Louis,

her Mr.
Don

1966

951

Mention
Missouri

mam:
Stupim has prepared the

follow-ting

spacifieatiom for

ﬁnkindofmlymwhiehmafintmttous
inpsydxo~
The various

Why.
the
through

features are available to us mu
couplex interaction 91' a 1710 m1 computer system.

I hope these are helpful.
Sincerely yours ,
Mex

Fink,

PM}.

Professor of Psychiatry

�</text>
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                    <text>~.. ...... «v.11

,

ﬂ”

”7,,“

"Wm”...

~-..r.7..,~-4n-

\"

--~~\

-~

"

-

‘

MW

9

, 1966

DmSMpixohaspmpamdﬁnfoumingapooﬂimim!
unmadmwlyaeswhiehmofmmmmmm
Wiley. havmtutmsmmihbhtomm

WWmluimmimofanmImet-u.
I

hope

the»

m halpful.

Simmly yours,
ﬂax Pink,

14.1).

MW of Psydxiatry

�</text>
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                    <text>April 12,
Mr.

1955

Did: Klein

#30 ”1110:? Ave.

St. Innis, Missouri

63135

MW. min:

$13»th

Mywmmtwmhtmmdthedamptim
IfItmhmtmdﬂnnatcsaor-mctly,
fan-manual pmimof $1,5801t is possible to obtain
1mm inth. mat of $50,000. While the not benefits
maintlnam,thnmiaa10mportimdaichirmases

Madly
asﬁumgommﬂntﬂnqﬂoftmmyyemthcinsmm
has avenue of$30,000.

mmmblmwiﬂzﬂﬁamodotimm,is ﬁutif
mamvimbcymdﬂnmtympem,aniaaaddladwith
adubtof$20,&amp;0. Pornamyycm‘asmmdntainsmmbt
than is an interest charge of close $1,000
to
this policy

W.

I

method and
how
mm
ﬁmabmkemytﬂmmmtﬁudmsmybesnﬁﬂy
unmanampadcage.

really so. no diffomm
318my:"ﬁst-tori?”51LA

‘

mail? of your data
*

Iwould"
W"p§3i?1:fwfﬁo"
'ah

laveagteathestm-"mdﬁmgmy ,; ey"
bomwingwumosmtialingndimt,imw1hmm
mtmadofdabts.
.

Wmfwymmmidamim
Sincemly yours ,
Max

Fink,

H. D.

Professor of Paydﬁatry
mug;

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                    <text>Octdber 30th, 1972
Donald Klein, M.D.,

Diractor of Research,
Island Jewiah~ﬁillsidelaueens Medical Center,
270-05 76th.Ave.,
Haw ﬁyde Park, H.Y. lloho.
‘

Long

Dear Don,
;

;

Folioving our discussions at the research committee
this morning, I would appreciate you asking your secretary
to aenﬂ to me, for filing and/or distribution:
(a) copies of protocols a! cngoing research
programs which may be made a matter or
record at this time.

g

(b) invitations

to meatings of a raaearch nature

~

the lattar to be aistributed to tbs committee
and to othar dapnrtmwnt members.

g

z

Sincerely yours,

Ml: Fink. N.D.,

Professor of Fsychiatry

g

M?/1J

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                    <text>rum

Oetdber 25th, 1972
Dumnld P.

Wt

master.

Klutn. M;D.,

of

Paciﬁsm

Research and Evaluation,

Hulda: Hospital.

75~59 263rd St-.
Glen 0:33, H.Y. 1100b.

baa-Don.
With regard 150 the two Mas cumming the Am.
I hare invited Richard Rania to attend the 1972 mating;
and have agreed to accent! the nomination of Jenn Simeon, 24.1).
of the University of Missouri. He will but nominated by
Tut-an Itil. Simeon worked with bath or us and we agreed to
make this
this spring.

m

mutton

.

I suggest (unofficially) you recommend ymxr snout:
attend the. meetings but they at a neighboring hotel . I
thc use of the acclimation:
am to recall the flap m
w mat: to that Islam Ind to not ucouodutim Gunner...
at the meetings themselves.
mm never was a prablan
Alternatively, tell Dick they m renown-ca peaplc for your

m

and will am at their mm menu. etc. If
Mum.
either in
in cannabis, thaw can he a "venom.

mud
m

person” for the

hoe

mm: nation.

Blncmly,
Fink, 3m.
m
Protuwr of

thutry

WI 13

w:

�</text>
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                    <text>March 25, 1964

Klein
}.Hillside Hospital
Donald

P. 0. Box 38
Glen Oaks, New York
Deer Dan:

I wrote to ﬂex a few weeks ago. I have been reviewing the
Chlorproneeineabepreoeioo paper. Enclosed is a page (to. your
comments made two years ago. I agree with your suggestion that
it might be useful to provide the data on two ocelee.

A:

A: I look at the results of some of our earlier deliberations,
I wonder is we have an a priori reason to use some of the items

of the Lorr, or modified scales.

the:

use problem 13, number: 1. 2. 3 and 5,
as being the ecolos that were sensitive to changes in depree~
eivee: however, as I look through the covariant analyses, there
are six of the Clyde Mood scales. the Lorr E, the JH depression,
and the withdrawal scale on word behaviot, each of which chow:
cone possible significence to: drug effect.
1

would ouggeet

I

would be

we

grateful

we

if

you would review your comment end advise

as to the best procedure to support this report.

on enclosing the lists of the patients given me by John. in
the event that you with to run a trial on any of these scales
before conﬂicting your opinion.

I

I look over thin study, I find that it may be eavioeble to
broaden the stove of the report to include, or tether to expend
the comperieone between iuipremdne and chlorptonesine in the de—
pressive subjects, for the original conception seen: too limited
in View of the date we collected.3

As

tell

Pleeoe

get to

tth.

e

it

at

Max

thet I haven't forgotten the EEG study and will
I have a better grasp of this report. Many

noon as

’

Sincerely yours.
“IX Fink. HID.

Director

HF/Jb
233 e

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                    <text>March 25, 1964
. Donald Kloiu

illlide Hospital

P. 0. Box 38

Glen Gets, New York

Deer Don:

I wrote to Me: a few nooks ego, l hevo been reviewing the
Chlorprouezine-Doproooion paper. Enclosed is 1 page from your
comments made two years ago. I agree with your suggestion that
it might be useful to provide the data on two scales.

As

of our earlier deliberations,
have an a priori reason to use some of the items

I look at tho result: of

A;

some

I wonder is we
a! the Lott. or modified neales.

I

would suggest

I

would be

that W! use otoblem 13, numbers 1. 2. 3 and 5,
es being the scales that were sensitive to changes in depressives: however, no.1 look through the covariant analyses. there
are six of the Clyde Hood scales. the Lorr E, the JR depression,
and the withdrawal scale on word behavior. each of which show:
some possible significance for drug effect.

me

grateful

if

you would teviaw your comment and adviuo

as to the boat procedure to support

this report.

no oucloeing the lists of the pationts givon me by John, in
the event that you wish to run a trial on any of those scaloa
before committing your opinion.

I

it

may be advisable to
I look over thin study, I find that
broaden the scope of the report to include, or rather to expand
the comparisons between imipramine and chlorpromazino in the depressive subjects, for the original conceotion aeoma too limited

A:

in

View

Please
get to

thmk‘ e

of the data

we

collected.’

that I hevon't forgotten the EEG study and will
it as soon as I have a bottar grasp of this report. Hany

tell

Max

Sincerely yours,
Max

Fink, E.D.

Director
HF/jb
ﬁne 0

.

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                    <text>Dcennbor 4. 1972

9m.“

1’.

Klein, :40”.

Hillside Hospital
P.0.

Box 38

Glen Oaks, Riv York
Dear Eon:

In packing my-books in ﬁg» York I came across copies of this
document ~ dcscribing our scope prograaa for psychiatric diagnosis
based on Diagno—II. I cannot recall tending out to you before, and

‘0 send this

now ~ yarhapa

it will uscful

to your team.

Sincerely yours,
aux Fink, M.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106815">
                    <text>-w. a?

«J'vwc‘ncmn'mu—r—"v‘ ~--—u~w

—-

rum.“-

.‘.m

,

y

I&gt;&gt;vw’w ‘m— w.

v1.7..‘_w.,.,_.w.-. .

,w v.7- ,.

.. .

;

.

. ”.4“

,_ ..‘.....».,-.w

w... .v, ‘7',“ V...”

7333—77283
16 Hovnmbar 1973

subscription Bapatcnnut
Coggrohcnsive Pszchiatgz
111 Fifth Arcana
Haw Turk, ﬂew York 10003
Re:

Chang: of Addtaas

thtlcnmnzl
Plants change the addrtsa at which I racotva nggrnhansive

Puzchiatgz to:

Dapartmcnt of Psychiatry
Health Sciuncol Canter
3.3.R.Y. at stony Btook
stony Brook. 3.!. 11790.
Thank you.

Sinnernly yours,
Max

Fink, H.D.

Pratasncr of Psychiatry

Hr/cin

�</text>
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                    <text>April 17.

196:.

Dr. Donald F. Kloio

Billside Bospitel

P. 0. Box 38
Glen Oaks. Rev York
Dear Don:

Thank you very much for sanding but} the depression papor so promptly. I
liked your comments, and ooclossd is the next draft. I did, as you roggestsd. tsks out ell tho EEG materiel which was not pertinent to the issue.
The two tables thet you insctted era quite good. The only quostioo that I

have about thsm, it whether it is necessary to include the statistical
values in the table. while the original study we: a random sssignMsnt. the
petisnts that we era not'extrsctiog for the study er: s subotaople which is
not watched. The ststistios. than. are possibly a poor guide to the data.
I think the tables speek for themselvos.
At the

coatsnt

now

stands,

we

prosent a desoription of the bahsviorai

changes with esoh compound. the global ratings, and the rate and reactivity
resonate. I wonder if we could bolster this with some additional data from
tho mood scales or some of the other depression scores. I liked whet you
did in the anxiety syndrome report and it soy be worthwhilo to add some
similar information. Enclosed is a copy of those covariance ennlysos which
were "depression lentititt". Porhaps wo could include some of these or s
teble like this. Also, in the new scales which hsvs been labeled Problem
13. nunbsrs l. 2. and 5 ere depression sensitive just as the rats and toactivity score. It might be hulpful to do s similar analysis for number 1

(perplsxity), or

5

(tension).

I deleted tho EEG ontoriel, I believs the facts proaontod were correct.
Before John left he did a review of the EEG dots with ohlorproostios lions.
and ohlorpromssine tad Keosdrin. Chlorpromalino. in gonersl, produced more
doits and that: activity, 1nd tho amount of hate was markedly dooroesed in
contrast to the combined drug use. As for imiprsoine, to have done many
analyses on tho Hillsida material and on additional experiments bars. This
because much of the expressed EEG changos are ralsted
it a fascinetiog study.
In general, gtvsn a record with considerable
record.
the
to
pre~treatmant
amounts of slots ectivity, this will decrease. there will be some thets
activity and beta activity will appear significantly. In tho presence of s

While

record with slow wave activity already, ospocially in epileptic pstientr.
the amount of seizure activity increases markedly sod one does not see the

�Dr. D. ?. Klein
4‘17—6é
Page Tvn

fan: nativity

Gar computur analynin program. havu been working
couplcttng In analysis of pontotbal. I hope to
art
take lutpramtna ncxt. bacauan I think
is a fascinating compound. Indeed,
I have rand your thaorotical paper only once, and my first impreautau in
that that. may be ton. incarnating unurophyaiologlcal material with tulpraalna
which may fit with you: moduli.
component.

vbry Hall, and U!

now

it

I rand the paper on anxtaty syndromes and found it very clear and interesting.
It is prcclaely this sort of autottal which items necasaary today as the basis
for I buttor undcrotanding of drug action. I don't havq such patients tn out
ward. It the proton: ting, but they probably 3:15: in clinicg and givon tha
opportunity, I vauld 11k: to bring your paper to tha attantion of loan of tht
out~pat10at psychiatrists, haying that thny will try your rccommeudattont.
Thank: one: again for your halp on the deprasatan paper.

Sinceraly yours.
Fink,
Director

Max

amt:
Enc 0

H. D.

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                    <text>September 10, 1964

Donald F. Klein, M.D.

Hillside Hospital

P. 0.

Box 38

Glen Oaks, New York
Dear Don:
copy of a letter from Jonathan Cole. regarding the
depression paper. Thank you very much for e copy of your anxiety
syndrome report.

Enclosed

is a

I have proceeded following the recommendations of the editors end
especially Jonathan’s comments at the and. and an correcting the
manuscript. The number of changes are nininal. end the only question is the method of handling the comment regarding page 14. first
paragraph. Since this is primarily a clinical paper. it seems more
appropriate to delete the allusion to the heuristic model than it
is to expand the description. I think it were best to permit you
to expand on this in another report.
While in England, I visited Dr. Martin Roth and hsd an interesting
opportunity to allude to our experiences with inipranine end veri~

ous depressive cases. He has a young psychologist working with him
by the name of Clair Nelson Guerney, who has done a number of factor
analytic studies of the date collected in a large number of depressive cases. She noted two factors that seemed to separate her suh~
groups. The groups included a neurotic-depressive group. a phobic~
depressive group, a psychotic—depressive group and a manic-depres—
sive, depressed. She observed that one factor separated the psychotic—depressed end manic-depressed, depressed from the other two
groups. But she was concerned about a very strong factor that
separated the phobic~depressed and psychotic—depressed from the
neurotic-depression and manic-depressed, depressed. I suggested
that perhaps this factor was separating a group highly responsive
to iniprsnine from those who were less so, and suggested that she
refer to your work and your report on the anxiety syndromes. I

think their findings are of considerable interest.

Sincerely yours.
Fink, H.D.
Director

Max

Mlljb
Enc.

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'

2O

30
LO
1:9~

Chic-go Attitude Scalo

Problal

thru

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1

95

11

20

96

21

30

97

31

ho

98

u

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�</text>
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                    <text>July

13 , 1965

Donald F. Klein, 14.1).

Director of Research
Hillside Hospital
P. 0.

Box 38

Glen Oaks,

mar

New

York

Don:

is possible and I believe that mch of the
either at the University or even at our own
laboratories if the analyses are small . The problem is not
one of whether, but by whom. There is little problem in
Everything

work can be done

winter time or in carrying out the actual naming
of the malysis. The major time maimed is in the preparation
for an azalysis and I dare say this is the biggest bottleneck
in the analysoo that you may need.

obtaining

‘

However, I will do the! best I can. The Hillside material
has been transferred from cams to a set of tapes which are
now at the University. I will have those run off and send
you a oopy. The various item will be coded according to our
problem numbers and them should be no problem in identifying
the various pages. Hwevor, as soon as I have such a capy I
will who what notations I can and then send these to you.
For any of the items or all of them, you can have a duplicate
tape or a duplicate set of cards, if you wish.

leisure time has overwhelmed me with the
desim to oomlete Irony projects , including; the recent submission
of the tri—hoopital study which has been accepted by tho Melvivu
06 Gmmz Plymmy and for which both Bob and Nat am thankful.
My

new found

My

best mgards.
Sincerely yours ,
ﬂax Fink, M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>.Ttﬂv 90, 1%.“

Dr. Donald F. Klein

Hillside Hospital

P. 0. Box 38
Glen Oaks, New York
Dear Don:
Enclosed

data as as

is

the

listing of the original Hillside Hospital

have on our

item is enclosed.

tapes.

The code sheet

identifying the

In addition, we almady have tapes which give us differences
between pm and post on each of these items, and different
scores
calculated from a
regression for all three treatments.

If there is

m

anything else

we

can do here, please

let

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

{1?sz
enclosures

no know.

�</text>
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                    <text>August 21, 1955

Dr. Donald F. Klein

Director of Research
Hillside Hospital
P. 0.

Box 38

Glen Oaks ,

New

York

Dear Don:

reason for sending the write-out of the data we now
m file is to indicate that these are the only items that
I still have available in either card or tape formt. When
you wked this question last tine I looked for the original
data sheets and I do not have them in my files. To the best
of my recollection all the data sheets were sent over to the
University and I do not know what their fate has been. I
have maintained the master cards and the two tapes in the
Washington University Coaputer Center Library, Thase are
the only data that am available to me .
have

My

Sincerely yours ,
Max

Fink,

M.D.

meassor of Psychiatry

�</text>
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                    <text>November 20. l967

Dr. Donald F. Klein

Director of Research
Hillside Hospital

Glen Oaks, ﬂew York
Dear Sun,

In response to your request. enclosed is a list of my
puhlications. All the publications between l955 and 1963
resulted from work at Hillside Hospital. In addition there
are citations in l953, l964, l965 and l966 which are marked
in the list, which are predominantly the result of work done

at Hillsida Hospital.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>,
o

.
.y

.
an.

A.

‘

..

.

"wwwuw

w,

w-..

.—.—....,

ﬂaw—w

WE‘un—“v

waaﬁ‘u‘ﬂ'

December 22, 1969

row

n"

'(yvvnm'v

'fﬁﬁmwi‘w

Dr. Donald Klein

ﬁillsido Hospital

P. O. Box 38
Glen Oaks, New York

Eear Don,

note to Dr. Essmen about urine collections seems fine, and I
have sent it on to Arthur Zeke who will contact you.
The

to Martin Green about the Indoklon-EEG records
to look at what may be available in
the records. If available, I'd like to send someone with him to
review the data.
I have spoken

wrn‘

m:

Mann-mun

at Hillside,
M'

Him

and he agreed

best wishes for a successful

1970!

arr-mum»

Sincerely yours,
rev-rm

“nu:

,r.
-

Fink, M.D.
Professor of Psychiatry

Max

mtg--

”Marv.

m-

;

Mszp

�</text>
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                    <text>"' «'"v‘w

'

-

'v

‘

.‘vlvriv‘l-V

vny'ogvr-wvtﬁeunh.

-

—.v-,..w....‘rp.)v.an,—.v

.,.._,.w.,_.;.,,¢ ”v.7. «m.

.

u

,,

,.

.

.,

“7.7,. *m'

,._».,,.

"my

.

..,. ,

,,‘_.

, .,

..

VWWHM, r,“

, _.,

January 11, 1971
Dr. Donald F. Klein

Hillside Hospital
75—59 263rd Street

Glen Oaks, New York
Dear Don,
Thank you for the descriptions of your-evaluation program
and the 1967 annual report. I will kepp your request for personnel
in mind, and bring it to the attention of our residents.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>P1»;- k ~v’.&gt;.-vv

.

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F
,

;

February 9, 1971
Dr. Donald Klein

Hillside Hospital
P. O. Box 38

Glen Oaks, New York
Dear Don,

of the APPA
behalf of Milt Greenblatt and the Council
work you did on
we wish to express our gratitude for the fine
annual
meeting.
behalfoof the APPA for our
The arrangements were excellent and I hope that the Association
will renew the contract with the Roosevelt.
On

Hany

thanks.
Sincerely yours,

Secretary
MF:kt

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                    <text>73SBn848SB
28 Decombcr 1973

Craig Burroll, M.D.
Vice President-~Roooarch

Sandoo Pharmaceuticals
Hanover, New Jersey 07936

Dear Craig:

Sitting in Loo'e choir loot week. he told no of the many
interesting things thet you seem to be doing. It must be a far
cry from clinical drug evaluations. Yesterday, in reading a
list of new publications. I found e citation for The NonrModicel
Use of Drogg; Contoqggrory Intervention Isoucg. The citation

dooe not have an address for the publisher, and I would be grote~
ful if you could have your secretary send on tho publisher's eddrooo end the price so that we can obtain e copy for our librery.

In October I had tho opportunity to vieit Sendoz in Basel
and presented a colloquium on my favorite eubjoct, the CNS of~
facts of psychoactive drugs. I was delighted to find their labo~

tatorios fully equipped to carry out computer processing of

proelion.
My

mwa-VWW'WTW25

regards and boot wishes for a healthy 1974,
Sincerely yours,
Max

Fink,

M.D.

Profoueor of Psychiatry

-

2x".'1w.11

EEGe.

Both Dr. Roubicok and his co~wotkor, Ht. Metejek, have done a
uplandid job in programming. I hope that those mothodo for predicting psychoactive drug effocte will find coco practical ox~

MF/cie

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                    <text>Catcher 2nd, 1972
F. J. Kuhn. Finns,
Departannt at Ph¢rnteology,
6507
Oil
Whit Gar—any.
7,

in Rhoin.
'

nut: rrnna.
for your letter or Boptanbar 7th

Thank you vary much

-and ﬁha

intcrntﬁion an

HI»1256~MB. I hiv. takcn the liberty
compound amons.those under study for n

of including this
rdport thnt I hnv. swat rininhnd. I an enclosing
for you.
'

,

-

3 copy

-

I minted the rcpcrt by Dr. stockhan; in
but in rngdin; t3. reprint I agree that this
interesting antagoniut proportign.
__A'aun.

m.

Ann Arbor.
campound has

than;
‘linccrcly yours."

mt Pink. 3.0.
NF/td

�</text>
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                    <text>July 19,
Dr.

J. Zuhin

New

York,

19TH

mY.&amp;uehmmnncmnume
722 What 168th
New

Street

York

Dear Joe:
As a follow—up to our discussion two weeks ago, I wrote
a short editorial for Joe Wbrtis and Biological Phyahiatry. I know
that such opinions are out of fashion now, but expressing them may-

nudge the pendulum slightly 3°° atamcmomy of psychiatric
A

copy

My

of

my

for move it
disorders.

must

if

ever

answer to Klein and Spitzer

we

are to

is enclosed.

regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd
Enclosure

�</text>
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w wwwn—‘v \‘ny-"vuv'wvnvrw'Iw-w

wu'p.“~“nag-:7... “um...

..

-...

v

_

January 22, 1976
Donald F. Klein, M.D.

Hillside Hospital

Geln Oaks, New York
Dear Don,
am pleased that your idea for a consortium meeting on
research
biomedical
is progressing. I have written to Iver Small,
in his capacity at secretary of the Society of Bioihgical Psychiatry,
and have asked his support at the next meeting of Council. Since that
will be in June, if you have need of the Society support before
that time, please write to him directly, and I am confident that
he will act positively, even before the Council meets formally.

I

the

next you talk to Charlie, remind him that you need
support, as he is an active member of the Council.
When

SBP

Good

luck.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>rv"n'rrmw—uv&lt;

..—

—.v—w‘;w&gt;-&lt;

.m‘w‘w «tm'wb-

1

,

M

...-.»..-wum-.w-

~ .7

Harm.

—..

,

5"".‘1m.

w"

”my

~"a-F‘

- mm...“:r»—q——-"/~-m~vv—\T~~wv|Wuwm'w- r»,

.-

.....__ 71-12

June 30, 1976
Dear Don,
We

have done one pharmacodynamic study of bromazepam. The

report is enclosed.

these data, bromazepam is hardly distinguishable from
to the amount found in the blood when the EEG effects
are the same as those of diazepam, i.e., we thought bromazepam a more
active agent in the brain (high EEG levels) with lower bbood levels.
Schwartz and Conney of Hoffmann—La Roche suggested that the sensitivity
of the methods was such that there may be an error in the bromazepam
blood levels, and that this finding was possibly an artefact.
From

diazepam except as

The manufacturer is Hoffmann—La Roche;
Bookman (212 695 1400, x3772).

Dr.

Philip

any

clinical experience with the

the contact is

I cannot answer the clinical question as

My

compound.

regards.
Sincerely yours,
Max

Fink,

M.D.

we

have not had

(“Wm-w.

4

‘»

puwwmm—

�</text>
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                    <text>M,

—,r.

“WW",

..

_...

war-w

June 6, 1978
Donald F. Klein, M. D.
York State Psychiatric
722 West 168 Street N
New York City

New

Dear Don,

w...,.,...e..

Wow,

Thank you

for the corrections of the Hillside data.

this juncture, I cannot recall for sure what the question was
to which the answer was incorrect, but I do recall the data, more
or less, as you note in your letter. Whatever the effects were,
and we were impressed with the antidepressant activity of
At

chlorpromazine plus procyclidine, the marketplace, and our own
we were not that impressed with
the effects. I think what I tried to say was that if antipsycotic
drugs are active as antidepressants they must do so on some subset

activities since, indicate that

if at all.

of patients,

As you note, our failure to find a difference between
imipramine and CPZ was interepreted as an antidepressant action for
CP!. I guess we would be more cautious about that interpretation

now.

In any case, I thank you. I do believe that on toxicity
alone, mianserin deserves a rapid and determined appraisal in this
country. If it is true that it is antidepressant and if its cardiac
and anticholinergic effects are indeed lower, we should use it in
preference to the present TCAD. Good luck in your study.

I

Awe,

——-v._v-",_,..‘m"--

Institute

am

commiteed to writing a summary for Psychopharm.
done.
30, so will send you a copy as soon as

it

Bulletin before June
especially

Take good care of Geeg Asnis. He may be a
nurture him.

if you

Sincerely yours,

”(w

i-

pawn-v,

‘I-v'lv!

cm-‘r‘rﬂlﬂ

w-

n-

1

wwuwvw

scientist yet,

Max

Fink,

M.D.

.

�</text>
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                    <text>fire}?

November 10, 1988
Donald F. Klein, M.D.
New York State Psychiatric Institute
722 West 168 Street
New York City 10032
Dear Don,

received the note from Robert Clampitt and agree to being listed on the
NAFDI referral list. The emphasB on psychopharmaeology is well defined, but it is
not clear, from the limited material sent me, what the attitude of members of the
Foundation toward ECT may be.
I

If, in addition to fund-raising for research, the aim is to educate the
families and patients as to all available therapies, perhaps attention shouiqnbe paid
to the role of 801‘. All too often, referrals to our center initially refuse ECT when
it is deemed useful, usually because their physicians or families are antagonistic.
Good luck in this educational

effort.

My

best regards.

Sincerely yours,
Max Fink, M.D.

Profeuor of Psychiatry

�</text>
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                    <text>April 29, 1994

Donald F. Klein, M.D.
NY State Psychiatric Institute
722 West 168 Street
New York City 10032
Dear Donald,
After your letter about the hunt for the article on an evaluation of
psychoanalysis, I thought of calling Abe Lurie [516 681-5004]. He recalled a similar story,
stated that he had brought the tale to HH aﬁer sitting next to the author on a ﬂight. He
recalled that there was another evaluation done at Hawthorne-Cedar Knolls in the 1960s
The report was critical of psychotherapy, but could not give me any more data.
Perhaps you can jog his memory a bit more.
My best regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>December 21, 1982
Ms. Gabriele Kleindienst

Medizinische Abteilung
Hoechst Aktiengesellschait
Postiach 80 03 20
6230 Frankfurt am Main 80
West Germany
Dear Gabriele,

it was a pleasure to work with you in San Juan. Your records were
excellent, and I am delighted that you are working with such a centrally active
drug.

am planning a holiday in Israel in February. We will be leaving Tel Aviv
on Monday morning, February 21. The flight connections are difficult, but it should
be possible to be in Frankfurt that evening, and to work with you on Tuesday,
February 22. After Frankfurt, l plan to visit Peter.
I

It is also possible to visit Basie first (on Tuesday) and come to Frankfurt

on Wednesday.

Please let me know whether such a visit would be helpful, and if so, which
date(s) are the best.

,

Emily told me that the last subject in the penbutolol study is scheduled
for December 22. If that goes well, we should have the data analyses by late
January, and I could defend our findings, in person, in February. She asked me to
extend her best wishes for 1983.

mvx—x.

V~

My

best wishes for a happy, healthy, and successful 1983

l

A

'm.’

.v;

Sincerely yours,

-

.
.

”A

in.

“.1..-

1

”ﬂora",

-""L'."‘

“:5.

7""

-'

"mm”"mw"

r‘

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ﬁﬁ“’¢{‘ﬁ'i"7‘t’ﬁllrﬂ‘w€'

n

Max Fink, M.D.

Professor of Psychiatry

�</text>
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Ms. Gabriele Kleindienst

g
5;

:

;

‘E

E

Medizinische Abteilung
Hoechst Aktiengesellschaft
Postfach 80 03 20
6 230 Frankfurt am Main 80
West Germany
Dear Gabriele,

It was a pleasure to visit with you on February 21/22. Once again, you are
to be commended on the quality of the work that you have shown me. Keep it up ! I
hope that the discussion was useful.
We have received the reimbursement of expenses in the Betapressin study
in the amount of $7,990. Thank you. I attach a statement of additional expenses for

the latest visit.
My

best regards.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

:gn

ll
‘.I'

.

m-"I'

.-;w

v;
..

"W‘A‘I’H'

�</text>
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                    <text>February 3, 1983
Ms. Gabriele Kieindienst

Medizinische Abteiiung
Hoechst Aktiengeseiischaft

Postfach 80 03 20

6230 Frankfurt am Main 80
West Germany
Dear Gabriele,
Thank you for your letter of January 20, describing the arrangements for
visit
on
February 20/22. By now, you should have received a draft report of the
my
findings in the crossover pharmaco-EEG study of i-penbutoioi and placebo in 12
volunteers. 1 mailed it on January 28. i will be prepared to discuss this study during
my visit.

Attached is a statement of reimbursable expenses for this study. The
15, 1982 is exceeded, due mainly to the increased computer
time, since we carried out separate analyses for each measure and checked the
individual frequencies and different frequency bands. if there is any question, we
can discuss it during my visit.

estimate of November

My best regards.

Sincerely yours,
Max Fink, Md).

Professor of Psychiatry

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                    <text>November 15, 1982
Ms. Gabriele Kleindienst

Medizinische Abteilung

Hoechst Aktiengesellschaft
Postfach 80 03 20
6230 Frankfurt am Main 80
West Germany

Dear Gabriele,
Following our telephone discussions last week, we have begun a crossover
of
the EEG and behavioral effects of l—penbutolol at 100 mg and placebo in
study
12 normal male volunteers, following the specifications of the protocol dated
October 6, 1982, which we sent you on October 15. The data collection will require
about eight weeks; but because of the year-end holidays, these may not be
completed until January and the data analyses by late February.

enclose a draft of the sum mary report of our dose-ranging studies with _l_penbutolol. These data provide the basis for our recommendation for a placebo
controlled trial at 100 mg.
I

This assessment required 15 sessions, and I enclose a statement of our
reimbursable expenses in the amount of $3,630. Would please request a check be
sent us ?
For the placebo-crossover study, using the same budgetary allowances
(February 13, 1982) of $20/hour for experiments and $60/hour for computer time, I
suggest an allowance of $4,240.
My

best regards.
Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�January 28, 1983
Gabriele Kleindjenst
Medizirﬂsche Abteﬂung
Hoechst Aktisngeseﬂschaf‘t
Postfach 80 03 20
6230
am Main 80
West Germany
Ms.

mm

Dear Gabriele,
The artist's drawings for the Betapreasin report were done today, sooner
thanIexpected, solhasten to send a draft foryour-neview.

Ilook forward to seeing you on February 20.

My

baa: regards.

Sincerely yours,
Max Fink, M.D.

Profemor of Psychiatry

�'

"

«Va-wmm'

January 25, 1983
Ms. Gabriele Kleindienst

Medizinische Abteilung
Hoechst Aktiengesellschaft
Postfach 80 03 20
6230 Frankfurt am Main 80
West Germany
Dear Gabriele,
The penbutolol study report is now typed, lacking only the artist's
drawings for the draft to be sent to you. The EEG profile is clearly most similar to
that which we elicited for clonidine. We expect the figures to be ready by
February 4, and I will send a copy promptly.

have made reservations to fly from Tel Aviv on Sunday evening,
February 20, on Luithansa605 arriving in Frankfurt at 1950. I also have reserved a
flight to Amsterdam on Tuesday afternoon, February 22 at 1445 on KLM 21m.
I

Thank you for your and Dr. Grigoleit‘s letter of January 17. I shall
continue to do whatever I can to assist you in your studies and in developing the
pharmaco-EEG program at Hoechst. Reimbursement for services rendered are
acceptable, although probably more expensive for you than on a consulting basis.
Reimbursement for the direct costs of studies (volunteer fees, technicians, gig.)
and for travel are billed as expended. The consultation fee for the design and
implementation of a pharmaco-EEG study is $5,000. Hourly charges vary with locus
in New York, $100 and abroad, $150, with a daily basis of $800 in New York and
$1,200 abroad.

-

I

trust this is acceptable.

My

best regards.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

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                    <text>i i!
’1

-2x

,

«rm—'11

lK-O‘WV'.

a
i

Rovember 22, 1967

Dr. Gerald Klerman
Connecticut Mental Health Center
34 Park

New

Street

Haven. Connecticut

Dear Gerry,

This is to confirm the change in the date of your
presentation to the Nassau~NP Society from February 20
to March l9. I will be in touch with you before that

date and
My

we can

discuss the details of your

best regards

and

my

visit.

thanks for your cooperation.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.Mszp
cc: Er.

Kay

�</text>
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                    <text>.

-mvw':‘nwu rm“.

ww-vym

October 7, 1970
Dr. Gerald L. Klernan
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts 02114
Dear Gerry,

enclosing our reports on cyclazocine and naloxone and our
The summary of the June 4 meeting is all that is available
and will not be published separately. The meeting was a workshop,
designed to assess the state of the available knowledge and to chart
the needs for further study.
I am

pre-rints.

Since the meeting

have:

we

to continue to
available for research;

1)

Moved Endo (DuPont)

2)

Contracted with

3)

obtained

4)

stimulated a contract application from Alza Inc.
for a long acting, non—silastic device for naloxone; and

5)

set

make naloxone

Food and Drug Research

of

New

to develop a silastic implant for naloxone;
M

5050 from England and are

filing

York

an IND;

up an unofficial commission, headed by Al Freedman
and William Martin to stimulate further study (and

seek funds!).

It

before

would be a pleasure

my

next

trip,

Many

to visit

you in Boston, and I

thanks for the

invitation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
011C .

will call

'Wﬁw‘ W

---

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\- -.-

w-.r..v—r-&lt;V"Ww—nwi’ﬂ'w4_.m-.—w.w_—.—.mn_——-uvrw.w~....... F"..—

.n

W...

_

w

-H

w e- ”7—. “m"...

...,

.

.e......._.._v~

.V.

a.

.7

'va-‘W

”w.“

October 10, 1971
Gerald Klerman, M.D.
Massachusetts General Hospital
2

Fruit Street

Boston, Massachusetts
Dear Gerry,

I

am

Dr. Richard Abrams

ical Association.

writing in support of the nomination of
for membership in the lbericsn Psychopatholog—

Dr. Abrams served his residency training at the
York Hedical College. After one year, he was inducted into
the armed services and during his tour of duty, undertook
independent research studies into ECT. He designed and completed
two studies of unilateral and multiple ECT in the treatment of
acutely disturbed depressed and schizophrenic servicemen. His
experience provided the basis for more extensive studies at
the College into the mode of action of ECT, studies hhich he
has carried ott during the remainder of his residency and
subsequently, as an instructor in our Department.

New

has written extensively in ECT; and is now
studies of new drugs in mental illnesses; the
in
participating
of
trial penicillamine in schizophrenia; and the evaluation of
He

war—ru-

as»

w-

n»...-

qvnnr-sW-wwqw

infusions of sodium lactate as a model of induced anxiety. He is
a serious student, well liked by his patients and the staff, and
is an avid reader of the psychiatric literature. He is able
to formulate projects and understands the principles of design
He is one of our outstanding trainees and I
and controls.
am pleased to recommend him for membership in the APPA.

‘n‘w

“a.

v

Sincerely yours,

w—m:

m

«5:-

x
1w.

J-E'l'm-MIR‘

M.—

.

Fink, M.D.
professor of Psychiatry

Max

e 7...

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                    <text>November 3, 1971

Dr. Gerald L. Klernsn
Harvard Medical School
Hassachusetts General Hospital
2

Fruit Street

Boston, Massachusetts 02114
Dear Gerry:
membership
Award

w-

v.

.

.
v

,t

,
.

n....,....,.(.,.

m..."

for

For this work, he received the 1969 Clinical Research
of the Society of Biological Psychiatry.

During his residency, also, he carried out independent

verification of the lactate infusion test for anxiety neurosis,
firuing the

work of

Pitts

and McClure.

con~

Since returning from military service, he has established
a variety of independent studies at Metropolitan Hospital, in anxiety

and

in schisOphelits

I an pleased to

recommend him

for

membership.

Sincerely yours,
Max Pink, H.D.
Professor of Psychiatry

:

:71vr

Dr. Michael Alan Taylor
American Psychopathological Association.

As a resident physician, he use most industrious and
undertook independent research into the concomitants of post~partun
schizophrenia. Demonstrating that the sex of the offspring bore
a significant relation to illness in the nether, he subsequently
demonstrated that hormonal effects operated concurrently with the
staractic properties of drugs—- a conclusion derived from his data.

\,.,,.,‘v:..r.:.,,-.

awn...”

I an pleased to nominate

in the

83:13
Enc.

�</text>
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                    <text>October 11. 1933

Dr. Gerald L.

new

Mal Health Center
Mametts
Boston Psychopathic Hospital
7246

mm Road

Boston 15, Massachusetts

harem-y:

mm

Whip

in
Sm German for
I have meantly
had
asked
and
of
College
Newyohoprmoolegy.
thc mricm
Jon Cole t0 mas sponsor. He recently mate to tell ma that
sponsor
Mowldmt.asambmofﬁnmmtimm1tme.
Sm?
his
Would
be
If
willing
to
so,
sponsor
you
applicants.
auricular: Vitae is mlosqd.
In the matings in Palo Alto, I had mach occasion to roiled:
on yum commits mgar'dim the depmssion pmjcct. A suggested
for a depression pwjact using the collaborating mapitals,
ﬁmtbynowJohnhas
mdiscuaaedatgmat lmgﬁx,andlamsm
Marie
about herasked
have
already
I
sent you a eopy.
she
and
responded
such
study
a
regarding
feelings
my favorably.
She estimated an mission rate of 80.100 depmasim a year.

W].
PSC.

Mr

Itmstthatauehaeollabomﬂngstﬁymymofhelpm

Ifloanboofmmmxgmmbaw.
Hy

r;

best mgards.

Simly yours,
Max

Hme

“a

Pixic,

Dimctar

M.

D.

‘

�</text>
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                    <text>0mm» 2a,

1963

1». Gerald L. Kleman
7h Fonwood Road

Boston 15,

Mandamus

Daar Garry:

Plans: emu“ tbs mmmt. I intended that: a mpy of the
on]. ofSamGorslmbumttoymmdthatismclomd. I
muld appmciate your nominating Sam.

unapplicaticnmnr.mrnmfmm8ammalmadyhnon

Mt

My

best mguds.
Sincerely yours.

£4me
831C.

mm,M.Db
Director

�</text>
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                    <text>October 30,

1961!

Gerald L. Kinsman, M.D.

Assistant Clinical Direotor

Massachusetts Mental Health
Harvazd Medioal School
7n Formed Road,

mnter

Boston, 15, masochusotts

Dear Gerry:

I want to omgratulste you on your emellent
md @311:qu of what tumod out to be a rather
good session on pmdictors;
manta regarding
physiological predictors are most appropriate, and I am
'

summary

.

er

takingtho libertyofsmdingyouaoopyofareport
think it smmmzes our
that I presented at C. I. N. P.
present position in this mlioeted field.

I

My

best regards.
Sincerely yours,

m Fink, M.D.
mf/ls
welcome

�</text>
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                    <text>bummer 12,

mam,
Assistant Clinical
Gerald L.

Watts

£4.10,

Mmctor

mum malt}:

Medical School
Wald
Femood Road

Center

-

7n

Boston 15. Massachmetts

Bureau-y:

Implemedtoencloseﬁmmacopiesofﬁxe
I
wwldbepleamdtohaveyoudistﬁbute theaet-oyow
Expression paper, which I have had duplicatedhem.

associates.

Sincerely yams ,
ﬂax

Pink,M.D.

Director

sills

enclosures
,

1961;

�</text>
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                    <text>September 21, 1965

Dr. Gerald L. Kleman
Yale Department of Psychiatry
Yale Psychiatric Institute
Yale University School of Medicine
New Haven, Cormectiout
Deer Gerry:

First, let me them: you for your kindness in taking me
homsouaeweeksego. moment fewdaysareablurbutbynw
my mother and my family are adjusting to the loss, as well as
one

cm.

I have just read your report on the clinical phammoology
many aspects of the pharmacology of
innipmmim which are new to me, and I found myself reading it
ammberoftimes duringthepestweek. Ifthere is any
question, it is only to the euphssie on mossines and the
limited infometion regarding the drolinergio aspects of this
. I cmnot help but feel that the antidepmssmt
features of this oompomd my be sore related to its central
effects on oholinergic mechanism than on any other aspect of
brain function that has been described so far. We lack the
methods to study this system with sufficient quantitative
amacy so that this aspect will have to wait further study.
of indpmmine . There are

~

«,m-mr

"Or?!”

""-"“i‘»

'
’

me

“

'2

‘

I would be very grateful if you would make available to
a reprint of this report when it is available.

r"
H

'x

My

7

best regards .

V-

Sincerely yours ,
.v'ﬂaw-”3W?r’ﬂ‘ﬁrrxiqcl‘WnJA

Fink, M.D.
Professor of Psychiatry

Hex
1"}

1‘1?sz

WHEN:

7*
.

�</text>
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                    <text>January 23, 1968
Dr. Gerald L. Klerman, Director
Connecticut Mental Health Center
P. 0. Box 1842
New Haven, Connecticut 06508
The

Dear Gerry,

It was kind of you to accept my invitation to participate
in the resident training seminars in psychopharmacology of the
New York Medical College.
have requested a special meeting of the class on Tuesday,
at 4:00 p.m. The meetings are held at Metropolitan
97th
Street and First Avenue.in the fifteenth floor
Hospital.
I

March 19,

classroom.

it

would
you can see from the enclosed list of seminars,
would
in
discuss
social factors
the evaluation
helpfulif you
of treatment and in the effects of psychotropic drugs.
As

be

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April l8. 1968
Dr. Gerald L.

Klemn

Associate Professor of Psychiatry
Yale University School oi Medicine
333 Cedar Street
Haven. Connecticut

New

Dear Berry,
Enclosed

visit to the

is a check for your expenses in your recent

New

York Medical

College. Again

my

thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>w-p‘

v-..

7388-653

Ayrtl 30, 1973

Joya: Lavinson,

M.D.,

Rational Assoc. far the ?ravantion of
Addietion ta Ehreotiaa.
175

Fifth Awu..

new York. N.Y. 10010.

Dcur Joyce,

Fallawing our letters of curly March, I hnve not
heard fron.you regarding the wanting: in Yugoslavia.
There 13 a possibility that I
during that ﬁlms. If it is at some

will be in Europe

interest. I

would

uppreciata any inrbruatian regarding the meeting which
you may hnve awnildble.
my

best rognrds,
Sincerely yours.

Nb: Fink, M;D.

Profonlor or Payehigtry

MFIIJ

�</text>
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                    <text>7383-656

April 30, 1973
n

..

v

,

.A.-,

‘1’

l'vpv-Ir

wJVy-nz-I—J'n‘

Gerald L. Kliiﬁhn, M.D..
Professor of Psyuhiatry,
Harvard Mbdical School.

Musstchuaettn General Hbspital,
Boston, ﬁnes. 0211h.
Dear Gerry,

I

grataful that you urn willing to mar?! an
of the Myabaruhip Oommittea fbr the AP?A.
I discussad with Jon tha addition ta the Maﬁbership

Chnirman

am

Committee of members from Boston and washington, and
ha agreed to ask yuur advice the next ttme he chatted
with you.

ﬁbula you poll the Madbarahip Cummittee sud be
prepared at the Council maetins to make a fbrusl
suggestion regarding an increase in maﬁberahtp, both
in number and in elasnitieution! (Perhaps one way of
gutting sround the foclins or elitism in to create tun
cllﬂl0l of numbers. such an tha ACHP did. I am not
reeounnndtns this, but suggesting it an a nutter fbr

discussion.)

I lack forward to neatng yen at the

and

of

Mhy.

Eincerely yours.

Mn:

rink, m.n.

Prafclsor of Psychiatry
MF/ij

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                    <text>7383—613

April 9th, 1973
W-

~

-

u¢rwm~r—.-.

my.“

Gerald L. Elurmen, M.D.,

Hhssaehnsetta General Hospital.

Boston, Hess. 0211h.
Deer Gerry,

Fbllawing our discussion in Kev Orleans, I
reached Jon two days after he bed seut out the list
of invitations fur the Heatership Committee. He
van therefore unable to make the corrections that you
suggested.

I think it would be epproyriete for you to
frame a series of recommendations regarding an
increase in membership in the APPA. and the constitutional
changes that would be necessary to accomplish this
mission. These should be presented at the next meeting
at Council, and the group's opinion determined. I
believe yen will get a favorable response.
As for the Arrangements Committee, Jon suggested
Jim Barrett , me you suggested c. Pierce. mania}; mm
Jon should invite either or bath to work 171th yen.

wheat you for your kind thoughts. Much of the
motivation for expeneion of participation by the members
in the APPA cane tram cur discussions and your letters.
I an. as always, grateful fur yuur advice.

Bineerely yours.

Mb: Fink. M.D.
Professor of Peynhietry
rum/1.1

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                    <text>mTJﬂVW

wan;

J:wm&amp;m

7383-582
Miran 213%, 1973

Gerald Klermnn. M.D.,

Profaauor or Paychiutry,
Harvard Mbdiaal School.
Erich Lindemsnn ﬁhntal Health Ccntar
ﬂovarnnunt Center.
Bosﬁon, ”has. 0211h.
Dear Gerry,

Follawing are coma comments on tbs ACﬂF task force notes of
6th deruary. 1973 regarding both the ganoral connidcrations and
tbs proposal for evaluating antideyrcnsnnt drugs. my comment:
may also be relevant to the notes by Uhlcnhuth and Wittenborn.

l

D

While

etio of base of at
the general utnxamnnts

alicit

criticism. I am confused by the mission.
safety are different tram guidelines fbr
necessary differences in rules :0: phase
by «aperioncad clinicians from rulaa for

approval and little
Guidelines for testing

efficacy. There are
I and donatinding studicl

phase III general clinical
surveys by an army of technicians. and phase IV clinical trials by

hosts of practitioners.

I read the guncrnl eonsidnrations, these seem recanted on
utudics - varifieatien a! efficacy in small tangles
II»!!!
phll.
A:

by techniainns. What or tbs apoainl issues of
(9.)

identifying clinical populations (phase I)

(b) doslgc usasuruuent

(a) plmiologiou affects including toxicity?
In the guidelinoa. the seloetion of degraaaod patients is
sacred no a lymgtau, cauglcx. and a diseasa. and rouolvuu tbs
dilamms by approving all ﬁbula. I belicve these distinction. to
be inpartanm,and while thn identification of homogeneous yopulaiiona
for phnso III-IV studio: in a difficult chore, it is any that neeaa
eumhnsia. Thane diltinetions are Ivan were important in phage I
trials. where hnt¢ro§enaona populations should be encouraged, and
thc data presented not as atumiaticul "salamia" but an eaaa roeords.

t

�‘Dr.

Gerald Klernen

~2~

Mirth

alet.

1973

interrelation of eymptem, syndrome, or disease end
intervention. (The eeee‘studiee by Klein make e unique contribution
in this regard, and eupport for such studies is warranted). Again,
the distinction of goele of eeeh study dictates distinction es to
methods, and I suggest that the guidelines than: on different
”phases" with different guidelines. (Fer another opinion, see
focueaed en the

Ballister Iencloeed)).
23

Digtineticn of dogaae

Differences in dbeervetiene. particularly as to efficacy.
are related not only to the tergut symptom and population seleeted,
but delivery of adequate doses of the agent to target urgent.
Repcrts of wide differeneee in blood levels with thymoleptiel and
lithium, when patients ere given the same dosages, has led to
Ipeeuletion (bout genetic differences in metabolite effecting
therepeutie results. While genetic and metabolic differences may
indeed operete, the inteke, ebeorption, and the influenee of feeding
éoeege ere eimpler. more mechanical issues that reqtire study. As
with the utility of blood lithium, and blood DPH levels, perhaps
the recommendations should include comments that where physiologic
indieee exist, therapeutic studies should include concurrent
dosage—index measures: at e minimum, daily (or more frequent) urine
end'blood levels; and, so frequent heart rate. EKG, or cerebral
bioelnetric measures where these may reflect tissue levels. Cerebral
bioeleetrie measures, reflecting the effect or an agent on e target
argue most directly in antidepressant therapy, are the best index
of changes in cerebral aetivity, end here wider a plieatione than
the guidelines reflect. (Cerebral potential [EEG studies also ellov
en identification and classification of antidepressant, thymoleptie,
end euphorient drugs, peovidins a guideline as to the related

_

comparison treatment).
31_Heeeg;ee of
To

some eecegtenee of e new antidepressant, only
some cardiotemicity or to effect the lens of the

gain

it to have
wuuld

toxigity
to find

eye,
serve eoeiety little. I have been coneerned by the neglect
er eerdiec toxicity in early eveluetiens. for example, with
thioridesine and meeoridesiae. An evaluation that does not coetraet
e profit-east eeeounting is e poor evaluation: to estimate effieeey
is limited if it does not eentrest with the esteblished, "effective“
standard. Thus. the guidelines may suggest that change scores of
behaviortl measures ehauld be evelueted in the same net as ehensee
in blood. cardiac, cerebral, ete. memes. (m. after item: 1 and 2
[page h], there should be en eeseeeuent of "neeendary" effects).

(In this regard. item: h, 5, 6, 7 ere clearly poet~eveluetion
indiees, useful to the technicians and elinical researchers, but net
relevent to evaluation in pheneIIIIII efficacy and safety).

-

�“It:

wanna

—

1mw—

r,..,w.°4-1,‘

'

wm‘7e&lt;»-.‘

varnn—s

‘E‘F'V-W

Dr. Gerald

new

~3—

march

21».

1973

There is a particular prdblan in assessing antidepreeaants:
the ”standard" is not well aeeepted. fer imiyremine and amitriptyline,
MAO. and EGT are each queted by different evaluator! far different
purposes. Fbr a "unJor" antidepressant. it may have he be contrasted
with ECT. Fer the othere,'with imipramine. The guidelines might
auggeet when to use which contrast. and perhaye discard any continued
use of MAO inhibitors aa a standard.
The eeparation

of phaae of atuiy and heterogeneous, case studies

fer phase 13 emphasis on homogeneous population: fur phase II, III;
distinctions of dosage and physiologic indieee; and eoetuprofit
analyses fer toxic ayumtome are questions that are alto lacking in
the antiwanxiety guidelines. ﬁne notes by Vitteﬁborn reflect an
interest in a very late phase of clinical testing. and.yet he attempts
to approach the relevant inauea. .Aa I read his eaten. hie emphasis
is on phase III, large aeele testing ~ he netee the frequent
diffieulty in dosage. washout, etc. that are also relevant to the
issue a! antidayreaeente.

Perhaps the guidelines are only focuaeed on phase III~IV testing
these notee are inappropriate. Perhape
phase I trials require different guidelines, and such a separation
an Wittenborn suggests; then

be useful in separating and clarifying the guidelines.
er the Cenmittee vieh an elaboration of these thoughts.
I will try to amplify than with more specific suggestions.

of goal

may

Sheuld you

aincerely yours.

w&lt;.z-¢nuv.v.-ur~vrr

r-uv

‘1’\“-r_""l7

ﬁnk . Md).
N
Protester of Psychiatry

"var-qr.

MF/iJ
3Q. To B. WittOnbOm. Ph.D.

�</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55672">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="55673">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="79769">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="86330">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="92891">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="99452">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
