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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

�</text>
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                    <text>May

10. 1968

Dr. Michael C. Barry
Medical Department

white Laboratories. Inc.

Ksnilworth.

New

Jersey 07033

Dear Dr. Barry:

Enclosed

is

a proposed Statement of

Investigator

Form (FD l572) for the high dose fluphenazine study.
In addition. I am enclosing copies of the report presented
at the CINP and a summary of the proceedings of another

related confsrencc in Sitges, Spain.

Please edit these and the proposed project to your
satisfaction. I look forward to hearing from yen.
Sincerely yours.
Fink. NJ).
Professor of Psychiatry

Max

HF:kp

cc: Dr.

Itil

�</text>
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                    <text>..
,-.

.

“Er—v

mm».

w

May

’ru
-rrr

1
raw

your

;»~:

.5,,

l0.

1968

Dr. Robert Summit
St. Paul-Ramsey Hospital
St. Paul. Minnesota SSlOl

V'er

s:
vr-v

,rrwa'm—H'u

w

mnww

ﬁv—rmwwm/mw

W:

vmm-

Wu:

W:

Dear Dr. Gumnit:

Enclosed is an abstract for your consideration for the
forthcoming meeting of the American EEG Society.
I

trust this is acceptable to

Thank you

for your consideration.

you and your Committee.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hey 10. 1968

Dr. E. Ned Schultz
Director, Medical Affairs
E. R. Squibb &amp; Sons. Inc.
460 Park Avenue
New York. New York 10022
Dear Dr. Schultz:
On my

enclosed

return

summary

would be useful

from the Sitges conference I prepared the

for presentation to
to you.

my

staff.

Perhaps

it

take this Opportunity to thank you for your kindness
during the meeting and your recent consideration.
Hey I

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>May

10, 1968

Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New

York,

New

York

Dear Alain,

draft

is a
I have

copy of the summary of the Sitges
Symposium.
prepared this as a summary for my staff,
but
may be useful if you plan to prepare a volume of the

Enclosed

it

Proceedings.

that

you do prepare a volume, we would
like to summarize our observations in New York more adequately
than are represented in this summary.

In the event

As I

indicated

Dr. David Graubert

on

the phone. one of

my

is anxious to undertake

a

former associates,

clinical trial

of depot fluphenazine and if such a study could be structured,
we would be pleased to process the data in our center or assist
in any other way.
Thank you once again
the symposium very much.

for your kind remarks.
My best regards.

I

enjoyed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>;

E

Mira-7' ‘

5/

4

W
T0:

Dr. A. h. Freedman

FROM:

Dr.

M.

Fink

DATE:
SUBJECT:

May

l0. l968

Application of Dr. Dinnerstein
for research program on marijuana.

The theoretical problem posed by Dr. Dinnerstein is a
relevant and important one. especially the desire to measure
the effects of marijuana on automobile driving behavior.
This has public health implications as well as some theoretical

value.

The

large -

Drug

slightly

choice of subjects is good but the number seems unusually

250

trials is

a very

large sample.

administration is clear and perhaps might be modified

by drug experience.

test battery is

adequate to the theory. The number of
which these are going to be administered
is probably too large. but I assume Dr. Dinnerstein plans to run
some trials first and then select the most interesting test models.

tests

The

and the time

at

Criticisms: Perhaps the biggest criticism is the comparison
with ethanol for this puts the study on the basis that the ethanol
group was selected for some logical reason. This is not clear in
the text and I do not think the two drugs are either opposed to
each other or are necessarily similar to each other or that the
findings in a comparison bear any necessary relationships to each
other. Because of this comparison group, the number of subjects
.

becomes so
The

large.

section of significance of research leads

that the selection of ethanol or

me

to feel

even the study of cannabis
arises not from the public health interest. but from the popular
enthusiasm for cannabis. I would have thought that a study of
motor performance under cannabis on acute and chronic administration
of cannabis would contribute to our understanding of its physiology
in a shorter time than the proposed study design.
Dr. Dinnerstein does not make clear that he is aware of
the difficulties of obtaining permits to carry out marijuana
research.

�Dr. Freedman

~2-

May

10, l968

It is probable that our own acute and
- Behavioral studies could be significantly amplified
by psychomotor studies such as outlined by Dr. Dinnerstein and
a collaborative study might be considered if the goals were
simply stated.
Recommendation:

chronic

EEG

,

_

Considering the present funding policy of NIH, I think

this application is too large to

be reasonably supported and
the Research Committee might be warranted in recommending a
less anbitious program as an initial experience with marijuana

for this investigator.
MF:kp

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                    <text>May

9, 1968

Dr. Perry Black
2006 South Road
Baltimore, Maryland 21205
Dear Dr. Black:

Enclosed are corrected pages for the manuscript
"Drugs, EEG and Behavior" following your suggestions

0:

‘mrr-wu—

—-

yesterday.

free Levin for the whole
volume, although if reprints are to be made available
if the publisher
to the authors, I would be grateful such
use, set up my
would, as partial compensation for
reprints with this paragraph as a frontispiece.
Table II should be corrected so that the heading
You may

use the quotation

for:

.

Ia

Mai

nly increased s].oving
Alpha
Seizure Activity

Increased
It With
Ic With Increased
IIa With Increased
IIb With Decreased

Amplitude
Amplitude

in each column should be listed alphabetically,
but the parentheses should be maintained wherever indicated.
of
Also, in Table II the type selected for the title
be
should
class IV and V, alpha increase, alpha decrease,
and
Page
7,
III.
for class I, II
the same as the typeface
h marked in italic are to be rpplaced by
3
and
paragraphs
the paragraphs appended.
On page 8, a footnote should be added with the asterisk
after the word "phantastica". The footnote is appended.
EEG Applications” should
The title on page 8, "Clinical
The drugs

—

be

deleted.

page 9, the two paragraphs relating to the
should be replaced by the paragraphs appended.
On

deliriants

�-2-

Dr. Black

references
as follows:
The

May

on page 2 and 3 can be

at 3;. Digital
Psychophernacology.

9, 1968

brought up-to-dete

Analyses in
In Kline, ﬂ. and Leeks E.
(Eds) Congntere and Electronic Devices in Pezchietrz,

Fink

Grune and

Computer

Stretton, H.Y., p.

EEG

109—123, 19

.

Itil, T. and Fink, M. EEG and Behavioral Aspects
of the Interaction of Anticholinergic Hallucinogen:
with Centrally Active Compounds. In Bradley, P.
and Fink, M. (Ede), Antioholiner ic Dru e, Eleevier,
Amsterdam, p. 1&amp;9-163, 1937.
The citations should be changed on page 8 from Fink 35 e1.
(in press [a]) to Fink 33 e1., 1968. The reference to the
other citation was changed in the section on deliriente.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>my 9,

Ir.

Richard A.

1968

May

Division of the Social Sciences

West Texas State Unimity
Canyon, Texas 79016

Dear 1r. Lunacy:

Ymmletteraddreeudmminmmimmstbem

mivadinNawYmk. Imovodm‘twoyeareago. Ian
tﬂdngﬂulibwtyofwxdﬁugyamlemmm.mmm,
Associate Professor of Psydxiatry at the University of Miami

SdnolofMadicinearinWymomtmthimformyhelp

trutmyasaociatoaemgivoyou.

Inﬁnevmtmisoutof

tomyoumnywiahtomachm.J.M.C.}bldenatt}nm
institutim.

Sincerely yours ,
Pink, M.D.
Professor of Psydziatry

Max

MF:kp

cc: Dr. Ali Keakiner

Institute of
Mami
SHOO
Arsenal St.

St. Innis,

Wm

mam 63139

�</text>
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                    <text>r
«.

.1

,mvyu

nr'r‘p'twvw

-v~mwm',wv"~

'A-WE'W'A‘tw-w-

"I
V"

my 9,

1968

Dr. Richard A. Lindsay

Division of the Social Sciomu
State Urdvamity

West Texas

Cmyon, Texas 79016

mm Lunacy:

Ymmletmaddresudmminﬂissom‘imjustbem
moivodinNewak. Immmycmago. Ina
taldngtlnlibu'tyofmdingywletwmm.mxwkiner,
Associate Noam of Psychiatry at the Univmity of Miami

Sdmlofhdicimuﬂlmostymoontaothimformylulp

thatmyasaociatescmgiveyou.

Intlncvmtmiswtof

tamymmywiahmmachw. .H.C.Ho1dmatthem
instim‘tim.

‘

airmen yours ,
Max

Pink,

M.D.

Hofessor of Psychiatry

MP:kp

cc: Dr.

A11 Knsldner

Miami Institute of Paydﬁatry
51:00 Mam]. St.
St. Innis, Miami 63139

�</text>
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                    <text>.~_,,,

Hay

8, 1968

Paul de.ﬁaen, Inc.

ll

New

West

Nan Street

York,

New

York 10036

Dear Mr. de Haen:

I am interested in the "Drugs in Use" service
and possibly the "Drugs and Research". I would be
grateful for a quotation.
You may recall that we discussed this at the
recent meeting in Atlantic City of the American

College of Clinical Pharmacology and Chemotherapy.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max
MF3kp

�</text>
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                    <text>'

a.”

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v.

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‘

.‘V

May

Henry

M.

a,

1968

Stretton, Inc.

381 Park Avenue South

New

York,

New

York 10016

Gentlemen:

I would like to have two copies of the recent
issue of Comprehensive Psychiatry devoted to computers
in psychiatry. I understand there is a charge. Please

bill

us.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

,7

Avatar".

'
tuna-tr

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                    <text>Vm‘m.wvmr

W imam-qty“ .u .w”
1‘

..

_T...,.v.,..‘...m.n.,‘,—»,

,‘Tmr.

-.

u-

t,_..

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-.

.0

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-.

Irv&lt;=lm

,,
mun—w

w,

v
-

___.~..—,...—w-

May

a,

1968

Dr. David N. Greubcr't
3 Sl'xelter Rook Road
Manhasset, Long Island 11030
Dear Dr. Gmubert:

It was a pleasure talking to you on Sunday. I an pleased
to enclose a tearsheet of an article on fluphenaaim that my
associates and I have recently published, as well as a copy of
the swam-11y of the proceedings of a recent meeting held at
Sitges , Spain. In addition, copies of articles by Blachly
and Kurland are enclosed.

Fluphenazine enanthate is available as a oonmemial
5 cc ampules of 25 mg/cc.

preparation in

I

study.

am

also enclosing a

copy

of the protocol of our ongoing

In the event you would like to undertake such a study, I
to assist you and will contact the representative

would be glad

of Squibb.
My

best mgaxds.
Sincerely yours ,
Max Firﬂt, M.D.

Professor of Psychiatry

MP:kp

cc: Er. Marital

�</text>
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May

a,

1968

Dr. Fletcher Owens
A. H. Robins Company
11407 Cunmings Drive
Ridmcmd, Virginia

Dear Dr. Owens:
Enclosed is a copy of the report which we recently
read both in Tanagona and in Atlantic City. I believe
it will be published in the Proceedings of the CINP.

Sincemly yours ,
Max

Pink,

M.D.

meessor of Psychiatry

HP:kp

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                    <text>May

a,

1968

Dr. Eugene Laska
Rockland State Homital
Orangeburg, New York
Dear Gene,

I have received the reprints of our article in your
I am writing to inquire whether copies will be
sent to authors.

book and
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

14?sz

-n-—4v

“,1

‘
,r

Tuwyl

‘13-?“

�</text>
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                    <text>May

8, 1968

Dr. Leonard Brahan

Endo laboratories
1000 Stewart Avenue
Garden City, New York 115333

Dear Dr. Bmhan:
Enclosed

is

a.

copy of the report which we recently

read both in Tarragom and in Atlantic City, I believe
it will be published in the Proceedings of the CINP.
Sincerely yours ,
‘

Fink, 1w.
Professor of Psychiatry

Max

MF:kp

�</text>
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              <elementText elementTextId="32892">
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              <elementText elementTextId="32893">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>m-

--'-

-1W~'rv4-mrm'-‘v~o

-r‘

v.1...

‘2

May

:W;db!'ii.))~"~"'."‘r';ﬁ“-

8, 1968

Dr. E. N. Whitman

v»

Hoffman

459F‘W'5

Nutley,

We)»,

New

Inc.
Jersey 07110

p.»

'rr‘aaz—rv

V

:
-

w.».-,—

merww:

Dear Dr.

Whim:

Implomdtohvoﬁnwmmtymdimsw
mﬂmymmagaininmlmticcuy.

NW1

Yammntimﬂntkbffmnmwm

supplies may

WE‘"

”

1-425,"

r

var

'

*A

'5

become

pmdming

is of special interest to us. If

available for emerimntal use,

would

ympleaseletmhmtowrmmmywrite. Hammadma

towxdwtdmsmhstudies,mwehavezmt1ypmposeda
studyofthemscimuc‘beristicsofﬂﬁsdmg. Unfortmately,

mfirxiﬁntttnauppliesmlinitedandmmamdous

obtainamhfmmtewrsmm.

.
_

Iwuldlﬂmtophntoviaityouinmmmlwrﬁe

ﬁrr'm-w-Wrr»

toyouagain.

eczwr'i-w;

Sincerely yams .
Max ﬁnk, NJ).
Professor of Paychiaty

Mqua

cc: Dr. A.

M.

W

�</text>
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              <elementText elementTextId="32902">
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              <elementText elementTextId="32903">
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                  <elementText elementTextId="102519">
                    <text>May

a,

1968

Dr. Vincent Cremnta

(has. Pfizer 8 Co.
Grotm, Cormotimt
Dear- Vince,

At a recent meeting of the Fonmlary Committee

of Metropolitan

Ibspitalcnthemcmunendatimofthecminnmoftmmpartmnt

of Psyclﬁatzy and the Clairmn of the Psycl'xophamnoology Study
Group, ﬁziothixenewasplacedmthef‘omularycftheﬁospital
for- one year trial.

it

would
have remanded its use to our maidcnts and
he very helpful if supplies could be made available for their
We

use through the pharmacy of Metropolitan Hospital. Mrs.
is the chief pharmacist.

me

A. Cruzado

to have an adequate
it be possiblc for you to
clinical supply made available to tho plumacy?
Would

Sincerely yours,
Max

Pink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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            <element elementId="50">
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                    <text>3'

.
.ﬂmuMw-

“-3,,“

-.

I}

May

Dr. Robert W. Ballard
Medical Director
McNeil Laboratories,
Carp Hill Road

a,

1968

Inc.

Port Washington, Permsylvania 1903“

DearDr. Ballard:
At a meant meeting of the Pomulary Oaunittae of Metropolitan
Hospital on the recamBndaticn of the Claiman of the Department
of Psychiatry and the Clair-nun of the Psychophannacology Study Gimp,
Haldol (haloperidol) was placed on the Fomnlary of the Howital

for six nmths trial.

Wehaverecormendsd itsusetommmsidentsanditwwld
if supplies could be made available for their
use through the pharmacy of Metropolitan Hospital. Mrs. Quzado
is the chief pharmacist.
be very helpful

Would it be possible for you to arrange to have an adequate
clinical supply made available to the pharmacy?
Many

thanks.
Sincerely yams,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>May

8, 1968

Dr. Fletcher (Mans

A. H. Robina Cmpany

Cumings Drive

11407

Ridmmd, Virginia
DearDr. Owens:

At a recent meeting of the Formlary Committee

of Metropolitan

Mitalonﬂmemmmtimofthecminmofﬁwnapumtof
Psydﬁatxyandtmauimmofﬂnhycmphazmcology Study Grow,

was placed
1:57th
tr .

on the Foruulmy

of the Hmpital for six mutha

it

We have moannended its use to our residents and
would
be very helpful if supplies could be made available for their
use trmxgh the pharmacy of Metropolitan Hospital. Mrs. A. Cruzado

is the chief

pharmacist.

Would it be possible for you to arrange to have an adequate
clinical supply (emlusive of the special study in the treatment
of narcotic addicts) made available to the pharmacy?
Many themes.

Sincerely yours ,
Max

Pink,

M.D.

measaor of Psydﬁatxy

Mszp

�</text>
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              <elementText elementTextId="32932">
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                  <elementText elementTextId="102522">
                    <text>May

8, 1968

Dr. Ralph Jacobean
Endo

Laboratories

1000 Stewart Avenue
Garden City, New York 11533

Dear Dr. Jacobean:
Enclosed

is a

capy of the report which we recently

read both in Tarragona and in Atlantic City. I look
forward to receiving supplies of naloxone in the smmer
and hope that we can continue our studies.
My

best regards .
Sincerely yours ,
Fink,
m
Professor of Psychiatry
MOD.

MF:kp

,
pun

.

mlml-w—gm-wr-

nrﬂW'M'.

‘Wmvfa‘ir'E-e

I”

�</text>
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                    <text>.~.m.v..

—

nIWMr-w-r

'Vnu‘ym.

wu—

May

Dr. Joseph G. Bind
Sterling Winthrop Research

chsselaer,
Dear-

New

York 121%

a,

1968

Institute

Joe,

Bmlosad is a cepy of the report which we
mad both in Tarragma and in Atlantic City. Irecently
believe
it will be published in the Proceedings of the GIMP.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>un-

-‘.-

-,

,v.‘11';~.

v

“.rgvdm—

n

”W,

7

?

May

8, 1968

Dr. Herman C. B. Denber

Manhattan State Hospital
600 East 125th Street
Wards
New

Island

York,

New

York 10035

Dear Hy,

I regret that I missed Dr. Teller's presenta—
tion at the GWON, but I recall your saying that a
draft of his paper might be available. If so, I

would be

grateful for a copy.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>May

8, 1968

Dr. Magno J. Ortega
Chief of Professional Education
Department of Mental Hygiene
Napa State Hospital
Imola, California sussa

Dear Dr. Ortega:
Thank you very much for your kind invitation
plan to be
to visit Napa State Hospital. I do not EEG
Society
in California again until the American
meetings in September. Perhaps I could visit you
at that time and will write to you later this summer.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>May

Dr. Alfred

M.

8, 1968

Freedman

Chairman, Department of Psychiatry
New York Medical College
5

Best 102nd Street

New

York,

New

York 10029

Dear Al,
and

Dr. William Karliner is a practicing psychiatrist
in somatic therapies with offices both
specialist and
He has an extensive practice
New York.

in Westchester

at Gracie
He

and has

Square Hospital.

has heard of the reorganization of Grasslands

indicated

facility.

an

interest in participating in that

In the event you decide on the appointment of
an acting director, it might be useful to invite
Dr. Karliner to participate in the planning, development
ﬁe
and administration of a somatic therapy unit. He him
commend
would
and
I
do
so
to
eminently qualified

to you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>—

aw.

m

‘.

,.,,

a,
.q.

4,7,.

7-5,.»

5

“Armor

1-.

avvm.»1wFM-W

.;

mc?’

van-1

8, 1968

May

A
~r

v.1:

.
Fin

Dr. Jerome Levine
1‘1;aqm’,¢wilﬁfi

KW“

15.1”,

Psychopharmacology Research Branch

National Institute of Mental Health
susu Wisconsin

Chevy Chase, Maryland

:Tz'Wn‘WW‘

1‘

i“

Dear Dr. Levine:

I

ﬁrm":

"~
.

w

.‘ﬁ.

Q'M‘E-w

&lt;.
"Ir/z.“

”AMA”;

”tartar-

am

writing with regard to MHl3358-02 and the

deletion of foreign travel. The date of issue of
the actual grant award was “/19/68, although the
project period was 1/1/68 through 12/31/68. You
may recall that I had inquired as to the delay in

receiving this renewal award letter because it
seemed necessary to visit the University of Istanbul
during the month of February to provide the data for
presentation at the 1968 meeting of the CINP.
Based on our understanding that the revised
budget request had been approved by the Council,
the Chairman of the Department approved this foreign
travel. The total cost was $779.05.
I would like your assistance in having the
approved budget for HH—13358 revised to include
this sum ($779.05) for foreign travel in 1968.
No additional foreign travel has been or will be
undertaken under this grant.
Thank you for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFikp

cc:

Mr. Schwartz

�</text>
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                    <text>May

8.

1968

Dr. Turan M. Itil
Tophapi Serai
Istanbul, Turkey
Dear Turan.

selfexplanatory letter from Dr. Bailey.
I called him today and he will entertain an application
from us, approximately two years. perhaps three, in the
order of $l8,000 - $25,000.
Enclosed

is

a

Please plan on your return to stop off and if you
wish. the International Association would be pleased
to make such an application.
Alain Sanseigne called to say that
available for the Istanbul study.

no funds were

are still working to hard and trust that you are
enjoying yourself. My best regards.
we

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>8, 1968

May

Dr. William Zung

Veterans Administration Hospital
Durham, North Carolina 27705
Dear

Bill:

I trust the enclosed check will defray your
expenses for your recent visit. We enjoyed having
you very much and look forward to having you visit
at your convenience this summer.
I will be Chairing the Sunday afternoon session

of the Society of Biological Psychiatry and at
Dr. Koella'e suggestion will call on you early in
the afternoon.
My best regards.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

enc .

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                    <text>via-H"

.W'Jn

Aw...”

..

1v

May

7, l968

Dr. Norman Pitts
Chas. Pfizer &amp; Co., Inc.

Groton, Connecticut
Dear Dr.

Pitts:

Separately I have sent you the summaries and behavioral
rating scales of the subjects receiving Doxepin in our initial
Mental Health Clinic study. Enclosed is our interim report
which is our summary of this information.
I

trust these are helpful.
Sincerely yours.

F
1‘

.
I“

Max

I

amwuwusql

.MWVL.‘

w“.

;
1],.

w

-,
,
.

"14:54“

raw-r"

‘RM‘W‘Marwwwwmil/Mm!xi»

Fink, H.D.

Professor of Psychiatry

m-“

Mszp

�</text>
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                    <text>May

ﬁiss

7. l968

Sage Roson

Administrative Secretary
American College of Clinical Pharmacology
and Chemotherapy
230 North Broad Street

Philadelphia, Pennsylvania

l9102

Dear Miss Rosen:

the sessions of the American
If the College
is able to defray the expenses, I would suggest the
following:
I very much enjoyed

College no Friday and Saturday mornings.

hotel

Sl2.36

Meals

Transportation

(car)

8.00
20.00

$15733’

Thank you very much.

Sincerely yours.
Fink. “.0.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

2. 1968

Dr. Daniel P. Bobon'

Assistant

A

L‘Universite
l4

Quai de Rome,

Liege, Belgium

Dear Dr. Bobon:
my

Enclosed are representative reprints of the studies from
laboratories, as well as two preprints of work that may be

of particular interest to you.

It was kind of you to consider an invitation for your
forthcoming roundtable in Belgium and I trust that these
reports will give
In the efent

you an idea of our work.

that

you consider coming to the United States
fellowship, I would suggest that you write
approximately nine months in advance, indicating the probable
date of inception and enclosing a copy of your curriculum vitae.

for

a research

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
8M: .

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                    <text>V

May

'{nw

.
1.“.

2. 1963

v-

Dr. Corneliu Giurgeo

Head

of the Pharmacological Department

Scientific Direction

pry-‘1”“Inn-mnv-W-HHWIHXWMW—

Pharmaceutical Division
68. Rue Berkendoel

Brussels 6, Belgium

ﬂrMW-irw-mr;

Dear Dr. Giurgea:

pleased to.hear your report at the CINPaand to
with you. I am enclosing a copy of two reviews
which recently were completed for the ACNP. They describe
I was

discuss

'.l’&gt;(

"3‘41'V2W’m"’m

it

the state of our knowledge and provide

optimism that these techniques
I am also enclosing a
methods in greater detail.

W'W'lv

”WV.

't.

may

be

me

with a basis for

useful.

reprint which describes our

“I

7

My
-mix—.,,-;n'7—

best regards.
Sincerely yours,

_

.i

m

"F'

Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

Vw&lt;vwsr77

7'

.
,

',

W-WTT/‘W'HEW'

&gt;

�</text>
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                    <text>.

“ﬂue...

“—r“

.
we

N.

.m

.
_.

v.9.vu-mm...

May

2, 1968

yum-www'

.
,
urns

r”

v‘lvaWWL-nrrn/"Wm

3'
~

qu‘l-wmw

wm.xrx-W-jx-ﬁzmm

Dr. A. Cerletti
Sandoz Ltd.
4000 Basle. Switzerland
Dear Dr.

Cerletti:

First, let me commend you on a remarkably fine program
CINP. It was a memorable meeting and my friends and
at
I found the scientific and the social programs most rewarding.
the

While we submitted a copy of this report for publication.
Dr. Polvan, 0r. Itil and I made a few corrections and added
more approoriate citations in the enclosed copy. Would you
please use this in the publication of the Proceedings and
discard the prior copy (No. 11)?
Thank you

zen-unvv—vv

-:

for your cooperation.

In,

Sincerely yours,
Fink. M.0.
Professor of Psychiatry

Mex

MF:kp

ac:

«

A

_

‘.,.

nvm-W.v-v»m~

v
n'lnvv

4v

m-‘w-a-w—c‘:

Dr. Polvan
Dr. Itil

�</text>
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                    <text>May

2, 1968

Dr. D. Tedeschi
Smith, Kline and French Laboratories
1500 Spring Garden Street

Philadelphia, Pennsylvania
Dear Dr. Tedeschi:

pleased to hear your report at the GIMP and to
discuss it with you. I am enclosing a copy of two reviews
which recently were completed for the ACNP. They describe
the state of our knowledge and provide me with a basis for
optimism that these techniques may be useful.
I was

also enclosing a reprint which describes our
in greater detail.

I am

methods

My

best regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

enc .

�</text>
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                    <text>May

2. 1968

Hr. Lee Hanna

Director of

News

HCBS—TV

5l8 West 57th St.

New

York. New York l00l9

Dear Mr. Hanna:
He

would

appreciate

a

print of film

“:nti~na¥§otic” as prepared
0 “CBS”

by Mr. Earl

labeled
Ubill and the staff
Ho. 24556.

0

We understand there will be a charge for this prid‘
and I am prepared to reimburse H085 as suggested in my
discussion with Mr. Earl Uboll's secretary, Miss Hockman.
He would be very grateful if this print could be made
available before May §, which would penoit us to use
in
a special lecture on May 10.

it

Thank you

for your assistance.
Sioceroly yours.
Fink, ”.0.
Professor of Psychiatry

Max

MF:kp

cc: Mr. Uboll

�</text>
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                    <text>May

2, 1968

Dr. Charles Shagass

Department of Psychiatny

Temple University

Philadelphia, Pennsylvania
Dear Charles,
would you please send me a copy of your
the effects of drugs on evoked potentials?
Many

ACNP

review of

thanks!
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>May

2, 1968

Dr. Joseph 6. Bird

Director. Experimental Medicine

Sterling«winthrop Research Institute
Rensselaer. New York l2l44
Dear Joe.
Thank you very much for your letter of April 25. The
9rant~in-aid in the amount of $400.60 will permit us to send
Dr. Simeon to the meeting of the American Therapeutic Society.
if you could request a check payable
It would be least involved
Simeon.
directly to Dr. Jovan
We

have completed the data requested by you

for the

FEA

in the depression study and are

the oyclazocine patients
in the process of completing the narcotic addiction group.
Both should be available within the next fortnight.
on

Thank you

for your assistance.
Sincerely yours,
Max

Fink, H.D.

Profesnor of Psychiatry

Mszp

�</text>
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                    <text>ﬂay 2, 1968
Dr. Roger E. Meyer

Acting Chief
Center for Studies of Narcotic
and Drug Abuse

Rational Institute of Mental Health

5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear Dr. Meyer:

for your letter of April 22, and for your
we apply through the grant mechanism for
that
suggestion
funds for our marijuana research.
Thank you

I have received IND 4724 from the FDA and have written
Commissioner Giordano for a supply of marijuana leaf. A copy
of my letter to Dr. John Scigliano is enclosed.

Thank you

for your assistance.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Nax

Mszp

�</text>
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                    <text>May

2.

1968

Dr. John Scigliaoo

Center for Studies of Rarcotic
and Drug Abuse

ﬂationai Institute of Naotai Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20203

Dear 0r. Scigliano:
For many months I have been making the arrangemants

necessary to undertake naurophysioiogicai studies of marijuana
and its extracts. Before receiving the iotter from Dr. Mayer.
indicating that the supplies of these drugs can be obtained
from your office. I had uwitten to Commissioner Giordano for
the mariauana leaf.
we are equipped to undertake some preiiminary studies
of THC and wouid iike to make such axpiorations. At your
convenience. may we request 250 mg of THC for this initial

triai.

Thank you

for your cooperation.
Sincaraiy yours.
ﬂax Fink.

".8.

Professor of Psychiatry

Mszp
cc:

Or. Mayer

�</text>
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                    <text>May

2, 1968

Dr. Richard P. White

Associate Professor of Pharmacology
Department of Pharmacology
The University of Tennessee

Memphis, Tennessee 38l03
Dear Dick,

It

was good

to hear

study is going well.

from you and I

am

pleased that the

This study program is supported by MH-12567 (Pharmacotherapy
of Narcotic Addiction) and by funds of the New York State Narcotic

Control Commission.

enclosing copies of all the reports which may be
may be found at the end of
the naloxone study.
I am

relevant. Additional citations

While I can sympathize with your need to obtain more data,
perhaps I can make some contribution if a preliminary draft were
made available before the June meeting. At least would you call
me at your convenience and perhaps we can discuss your
progress

in that fashion?
My

best regards.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp
ENC.

�</text>
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                    <text>May

2, l968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

100 York
New

Street

Haven, Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new psychotropic drugs in the treatment 0f the mentally ill. Our
initial results have been encouraging and we would like to expand
these studies since they provide opportunities to test hypotheses
which may not be practicable in the United States. For example.
we have Just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.
such a program would include
Director
of
the Division of Psychopharmacology.
Itil,
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan, Chairman of the Department of Neuroosychiatry, University of
The

principal investigators in

Professor Turan

M.

Istanbul.

Thank you

for your interest.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>May

l,

l968

Dr. Leon Wurmser, Director

Psychiatric Outpatient Department

Sinai Hospital of Baltimore, Inc.
Belvedere Avenue

at Greenspring

Baltimore, Maryland 212l5
Dear Dr. Wormser:

Enclosed is a copy of our report which has Just been
accepted for publication.
I

trust it is helpful.
Sincerely yours,
Max

Fink, M.D.

Proféssor of Psychiatry

Mszp

�</text>
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1, 1968

Dr. Leon Hurmser. Director

Psychiatric Outpatient Department
Sinai Hospital of Baitimore. Inc.

Be1vedere Avenue at Greenspring
Ba1timore. Maryiand 21215
Dear Dr. Hurmser:
Enc1osod

is

a copy of our

accepted for publication.
I

trust

it

report

which has

just

is heipfu1.
Sincere1y yours.

Fink, M.D.
Profcssor of Psychiatry

Max

MF:kp

been

�</text>
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                    <text>.
u

W.~q,..—A~qw~w—v:.ws-.w-

wwﬁr‘h-nmvzl-t

w-

May

l.

1968

Editor

Lancet

Editorial Office
7 Adam Street

Adelphi, London, H.C.2
England

Gentlemen:
The

recent annotations 'Addiction

little

New

Style'

and 'Drug

reference to the use of
narcotic antagonists in the treatment of opiate dependence.
As alternate pharmacological models to methadone, clinical
trials have been undertaken with a long-acting narcotic
antagonist, cyclazocinel‘8 and more recently. naloxone.°‘13
These compounds provide engagement to the treatment program
not based on legal restraint or drug dependence ubiqﬂlgggyidggﬂwnmwm, agent.
an opportunity for habilitation and education so essential to
the addict's integration into the community.
Dependence:

A

Symptom' make

British arrangements for treatment of addicts
emulate
the unsatisfactory American experiences.
to
appears
We would commend these models to your attention for further
study in the new centers.
The new

Sincerely yours,
Fink. M.a.
Professor of Psychiatry

Max

Alfred M. Freedman, M.D.
Professor of Psychiatry and
Chairman of the Department
MF:kp

�</text>
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                    <text>April 30, 1968
Dr. Morris 8. Bender

East Shore
Kings

Road

Point,

New York

ll024

Dear Morris,

It

was a great pleasure to read the announcement of your
I know that your many students will be as
new appointment.
I
that
as
recognition came to you in the form that
gratified
did ~ a rostrum from which you can lead many other young

it

students into neurology and research.

Congratulations and my best wishes for success of your
Department and the New Mt. Sinai School of Medicine. Please
also extend my regards to Sarah.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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n.

April 30, 1968
Dr. Robert
‘

Jaffe

t of Neurology

Sinai School of Medicine

Mount

Fifth Avenue and 100th Street

New

York,

New

York 10029

Dear Bob,

for

Enclosed

is a

check

Dr. Bender on Hay 8.

for my subscription to the dinner
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M‘szp

�</text>
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Dr. George M. Simpson
Rockland State Hospital
Ormgebm'g, New York 10962
Dear George,
Our data on the laboratory changes was published in the
05 Clinical Phwmacotagy and I am pleased to enclose

Jamal

a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active
drugs in order to provide accurate ooncm'rent estimates of
the usual laboratory ranges. "Concurrent" is the important
term, since seasonal changes and changes in technicians,
m-agents and equipmnt cannot be predicted frun sequential
studies.
Itwas nice seeing

you

in Spain.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>E

E

u-q-‘n! ‘.

-

~

.,n

't'gr'

,

:.‘

“Km; Ham» .1u'»;"lV".V»'Z"
.

-

..

v.. ‘.._V,,“....\ m
,

.

.

m..- u m1:
$k. :1 , ,...;

.

r.»

a ,‘-.4
.

«.—

o... w- \' a.w.,.__ --.v« ,

April 30,
Mrs. A. L.

.m.

w.

W'W-W‘"-

v:

”«rvv

1968

szado

Metropolitan Hospital
Pharmacy
1901 First Avenue
New York, New York

5

E

Dear Mrs. Crusade:

E

E

Enclosed are two notes which I have received in the
last few days regarding problems in the prescription of
drugs fmn the pharmacy. I would be grateful to have you
check these.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬂcp

�</text>
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                    <text>April
Dr. Robert

30 , 1963

Jaffe

t of Nemlogy

Pbtmt Sinai School of Mid!»
Fifth Avenue and 100th Street
New York, New York 10029

Dearaob,

Enclosedisacmckfwmysubscriptiontotmdimm

forbr. Benderonﬁaya.

Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

�</text>
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-

x

“an.“

”M

-,.-

April 30,

1968

Dr. William Tabor

A. H. Robins Company
1W7 Cmnninge Drive

Mahmud, Virginia

DearBill,
Wehave

meeivedﬂnesupplyofbutapemzineplaceboand
p'Ihestudy

ﬂareportfom. Wyouverymchforboth.

isgoingvery wellmdwearebegirmingﬂxesmmryofour

initial data.

This

will be available in the next

two

Sincerely yours ,
Fink, PM).
Professor of Paydziatry

Max

MF:kp

maths.

�</text>
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                    <text>April

30 , 1968

Dr. George M. Simpsm
Roddand State Hospital
Omngeburg, New York 10962
Dear George,

Ourdataonthe labomtozycmngeswaspublismdintm
mum thcatogy and I am pleased to enclose

Joanna 05
a reprint.

I believe it is important that each laboratory study
patients on placebo medication at the same time as active

some

drugs in order to provide
omcmment estimates of
the usual laboratory ranges. "Concurrent" is the importmt
term, since seasonal changes and chmgss in technicians,
m—agents and equipment cannot be predicted from sequential

studies.

It was nice seeing you in Spain.
Sincerely yoLIrs,
Mm:

Fink,

11.1).

Professor of Psychiatry

MP:kp

�</text>
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                    <text>April 30, 1968
Mr. Henry L. Giordono

633 Indiana

NM.
AW,20226

Washington, 13.0.

Dear Mr. Giordono:
we

rvv-

&lt;

ru

:
vngr'

w»

_

In addition to our ongoing studies of narcotic addiction,
to undertake studios of marijuana and

have been omomaged

marijuanaextmota. Aoopyofapmtoool forauohastudy,
approved by the oomittoes of this College, is enclosed.
We

rave received a Special

m Stanp, Class 5

-—

marijuana,

also have filed INDH'IZH with the Food and Drug
Aministratim, DEW. A copy of the IND letter from Dr. Gibson
is enclosed as well.
No. 127-11; and

I am writing to request the Bureau make available for our
experimental use approximately one pound of mfinod or high
gmde marijuana.
Thank you very much

for yum cooperation.
Sincerely yours ,
Pink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April 30.

1968

Dr. Halter Modell, Editor
Clinical Phanmacology and Therapeutics
Cornell University Medical College
l300 York Avenue
New York, ﬂew York lOOZl
Dear Dr. Hodell:

is a revised copy of our report “Behavioral and
Naloxone in Heroin Dependence.“ The suggestions
of
Studies
and criticisms of the editors were very helpful and we have
considered these comments and included our responses in this
Enclosed

EEG

presentation.

items were not incorporated. The question as to expenae
of naloxone is unanswerable, since Endo Laboratories has consistently
Two

refused to provide a price.

They have indicated

that

stated that
expensive for
naloxone from overseas sources and in this way make
them. and have

it was

too

they might try to obtain

for future research.

it available

other reviewer asked whether the development of physical
dependence on cyclazocine served a useful purpose in discouraging
patients from deliberately missing doses of that drug. he also
asked what is to prevent patients on chronic naloxone from omitting
Your

doses during periods when they plan to use heroin. Physical dependence
to cyclazocine is minimal since the sudden cessation of treatment
results in a withdrawal syndrome of a grippe-like nature. This is
easily tolerated by patients. 80th the cyclazocine and naloxone
subjects omit doses during periods when they plan to use heroin,
but they learn to take their cyclazocine or naloxone soon thereafter
and

this

maneuver seems

to

keep them from becoming readdicted.

lead summary is provided. as suggested. Thank you very
for your cooperation.

A

much

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC .

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                    <text>April 30, 1968

m. Charles Slugass
Temple University
Dewar-ant of Psychiatry

Philadelphia, Punnsylvania

Dear Charles,

It was a pleasure having you meet with tha residents
Wissufﬁcienttoooverthemanyﬂﬂngsyoubought
andtohavespentmtimewithyouinSpain. Ihopethe
Claraduringtl’ntrip.
Many

than!
Simemly yours,
Fink, M.D.
Professor of Psychiatry

Max

Hfzkp

�</text>
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—

w“

~.-»-

A.

r1

r’v..V'—n—vr‘4vn’,—

)w-n'l

April 30. l968
Dr. Morris 8. Bender

East Shore
Kings

Road

Point,

New

York llOZ4

Dear Morris.

It

was a great pleasure to read the announcement of your
I know that your many students will be as
new appointment.
gratified as I that recognition came to you in the form that
did ~ a rostrum from which you can lead many other young

it

students into neurology and research.

Congratulations and my best wishes for success of your
ﬂepartment and the New Mt. Sinai School of Medicine. Please
also extend my regards to Sarah.
Sincerely yours.

“WWWW,~'_F

Fink, M.D.
Professor of Psychiatry

Mex
,....,.

MF2kp

�</text>
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                    <text>April 2n, 1968
Dr. Stanley Feldstein

The Willian Manson Whita
20 West Vuth Street
New York, New York

Institute

Dear Stan,

MyoufwtmcurﬁvulunvitaeofGailAlbem. I

donottmnkthisreoomﬁeﬂectswhatImlooldng for.

I did

send

My

it

to

Roy John however.

best regards.
Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April l8. 1968
Dr. Gerald L.

Klemn

Associate Professor of Psychiatry
Yale University School oi Medicine
333 Cedar Street
Haven. Connecticut

New

Dear Berry,
Enclosed

visit to the

is a check for your expenses in your recent

New

York Medical

College. Again

my

thanks.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>April 18. 1968
Dr. Jonathan 0. Cole

Superintendent
Ecston State Hospital

Boston, Massachusetts 02124
Dear Jonathan,

Enclosed

visit to the

is

a check for your expenses in your eecent
Medical College. Again, my thanks.

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatny

Max

MF:kp

enc.

�</text>
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                    <text>April

l5, l968

Dr. William Karliner

Franklin Road
Scarsdale. New York
20

Dear 8111,
A

repeat

EEG

was done on Miss

Harriet Bernstein

on April 4,

According to your note she has been receiving
Dilantin 400 mg. Tofranil 100 mg and Vivactil 20 mg/day.
(#409-M).

This record shows spontaneous seizure activity, high
voltage persisting for one to three seconds. The waves are
high voltage 3 to 4 per second with intermittent single spikes,
amplitudes exceeding 250 microvoltsJiith hyperventilation end
the seizure activity is enhanced. The background record is
filled with S to 7 cps activity with superimposed l8 to 24 cps.

is

In comparison to her

earlier records seizure activity
activity slower.

more prominent and the background

Im ression: This combination of drugs does not ordinarily
produce seizure activity. although reports of such activity after
imipramine are available. These reports are primarily in patients
with a seizure history.

The experience of seizures after convulsive therapy is
I would believe that such seizures would decrease with time

limited.

if

they are related to the induced convulsions. with these ideas
in mind. I would suggest that Hiss Bernstein’s seizure activity
is probably related to a process other than the induced convulsions
and also other than her present drug treatment.

�Dr. Karliner

~2-

April l5. l968

If her behavioral state has improved, then perhaps these
drugs should be discontinued. If she still is depressed, than
they probably should be continued despite the EEG record.
I

Thank you very much for the opportunity to see her again.
look forward to seeing you at Gracie Square.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
P.S. Dr. Paul Blachly is visiting me on Saturday. Mayll I
understand this is your usual working day and perhaps you could
set aside a few minutes to chat with us.

�</text>
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                    <text>January

ll,

l968

Dr. Francis Latteri, Chairman
Pharmacy Committee

Metropolitan Hospital
97th Street and

New

York,

Dear Dr.

New

First

York

Avenue

Latteri:

During the past few months, patients of the Mental Health
have received medication not prescribed or amounts that
were insufficient to provide for the time between visits from
the pharmacy at Metropolitan HOSpital. Such events were occasional
early last year but have become increasingly frequent.

Clinic

some

would

Also, the staff of the Department of Psychiatry have reviewed
of the newer dosage forms of established pharmaceuticals and

like to

May I

and would

agenda?

recommend

that these

be made

available.

inquire as to the next meeting of the Pharmacy Committee
be possible to have these two items placed on the

it

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>h

April i2. l968
Dr. Carl Salzman
Program Head. ECDEU
Psychophanmacology Research Branch.
5454 Wisconsin Avenue
Chevy Chase, Maryland

NIMH

Dear Dr. Salzman:

recently returned from a visit to Istanbul where
I have monitored our studies of butaperazine and high dose
fluphenazine. The studies are going remarkably well and the
'ease with which the data has been collected has stimulated
me to write to you.
The present climate for new drug studies is becoming
stonny as I and some of the other ECO U workers find the
. I believe there
FDA regulations increasingly restric
H. Denber, Don
ECDEU
as
group
are other members of the
who
have
an interest in international
Gallant and Burt Schiele
be
would
uaeful
to arrange a discussion
studies. Perhaps it
which
representatives of hdustry may
of our experiences to
be invited, so that this avenue of drug evaluation may be
opened. There are problems, for example. the acceptability
I have

of foreign data to the FDA. However. I think the advantages
of this work outweigh the handicaps and a discussion may serve
a useful public purpose.
I look forward

to seeing

you in June.

Sincerely yours,
Fink, ﬂ.D.
Professor of Psychiatry

Max

Hszp
cc:-

Dr.

J. Levine

�</text>
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                    <text>April 12, l968
Mr. Henry L. Giordano
633 Indiana Avenue, N44.

Hashington, 0.6. 20226
Dear Mr. Giordano:

.

'

writing to request the Buroau of Narcotics make
available to this Department of Psychiatry an additional
Z'grams of heroin HCl. (recryStalized) to continue our ongoing studies of antagonists in the treatmEnt of narcotic
addiction. I have called Dr. Eddy and he has suggested
that I write directly to you.
I am

i

A

similar supply

was made

available to us (Dr.

A.N.

Freedman, M.D., Chairman of the Department of Psychiatry)
on November l3. 1967.
Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc: Supervisor 6. Belk
Dr. N. Eddy

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                    <text>:7“.

April

ll.

##1va

l968

Dr. Paul H. Blachly

Associate Professor
University of Oregon Medical School
3l3l S.H. Sam Jackson Park Road
Portland. Oregon 9720l
Dear Paul.
Thank you

comparing

ECT

for your letter of April 4.
electrocardioversion.

and

and the

reprint

For your visit on May ll. we can arrange to meet you at
Gracie Square Hospital (76th Street and York Avenue) at l0:00 a.m.
on Saturday, May l. If you will let me know where you are staying
my associate. Dr. Richard Abrams. will be glad to pick you up and
bring you to the hOSpital. He can visit there and observe the
treatment program and i would then like to have you visit our
laboratories at the Medical School. while I cannot guarantpce,
a demonstration. i may be able to show you enough to make the

visit

worthwhile.

The program of Drs. Dole and ﬂyswander is the best program
for narcotic addicts in the city,(and possibly in the country)
and you should visit. Their principal center is at Beth Israel
Hospital which is at lath Street and Second Avenue. 1 would
suggest you write directly to Drs. Dole and Nysuander. indicate
your interest and your earlier experiences with addicts, tell
them of your invitation to visit our laboratories and ask for
an opportunity to see the Bernstein Pavilion on Saturday afternoon

or Friday evening.

A

visit

Your question about a
rings no hell with me. for

compounds.

should be very much worthwhile.

new beta adrenergic
I have not studied

Both Dr. Abrams and I look forward

blocking agent

it or similar

to your visit.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc:

Dr. Abrams

53%

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                    <text>May

2, 1968

Mr. Lee Hanna

Director of

News

HCBS-TV

518 West 57th St.
York, New York 10019

New

Dear Mr. Hanna:
wouid appreciate a print of fi1m No. 24556, 1abe1ed
"anti—narcotic" as prepared by Mr. Ear1 Ubi11 and the staff
He

of

NCBS~TV.

understand there wi11 be a charge for this prind:
and I am prepared to reimburse WCBS as suggested in my
discussion with Mr. Eari Ube11's secretary, Miss Heckman.
We

We

wou1d be very

gratefui

if this print

avai1ab1e before May 9,
a specia1 1ecture on May 10.
Thank you

which wou1d

cou1d be made
permit us to use

it

for your assistance.
Sincere1y yours,

'

Mszp
cc:

Mr. Ube11

Fink, M.D.
Professor of Psychiatry

Max

in

�</text>
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                    <text>May

2, 1968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

Street

lDO York
New

Haven. Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new

psychotropic drugs in the treatment of the mentally

initial results

have been encouraging and we would

these studies since they provide opportunities to

ill.

like to

test

Our

expand

hypotheses

which may not be practicable in the United States. For example,
we have just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.

principal investigators in

such a program would include
Director of the Division of Psychopharmacology.
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan,]Chairman of the Department of Neuropsychiatry, University of
The

Professor Turan
stanbu

M.

Itil,

.

Thank you

for your interest.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>April

ll .

1968

Dr. Tito B. Dinzey

Administration Hospital

Douney Veterans

Denney. North Chicago,

Illinois

60064

Dear Dr. Dinzey:

Hhile I regret the delay. I have finally obtained
permission to consider appointing an internist to the

Department

W)..-

.
1%.

w

w

.A,

staff.

I would

like to

have you

visit

us

at

our expense and ask that you call my secretary collect
at (2l2) 369~8488 and work out a time that is mutually

satisfactory.

,..-

Thank you

I
~

for your interest.

Wﬂm~sp

Sincerely yours .

.,,.,.,,_.._,,,,.

7

Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>April 10. 1968
Dr. Edward Gendel

Director Cytogenetics Laboratory
Metropolitan HoSpital
—

First

1901

New

York,

Avenue

New

York

Dear Dr. Gendel:
I have

Just received

a carbon

of your

letter to

Dr. Freedman.

I had asked Dr. Bucci to indicate to you that the procedure
to be followed in undertaking such a study would be to provide
a protocol, in sufficient detail to be acceptable to the Research
I asked Dr. Bucci to assist you and
Committee of the College.
I trust that he has been able to do so. since chromosome changes
with drugs is an important scientific and political issue.

Controls for drug intake, illness and age should be included
in the design.

letter of April 8 does not, in my opini
e
criteria for the Research Committee

Your

minimum

of Hospitals.
and

if

Department

I ask you to please meet with Dr. Bucci again
you need additional assistance, please have him call on me.
May

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. A.

M.

Freedman

�</text>
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                  <elementText elementTextId="102562">
                    <text>April 10. 1968
Dr. Roger Mayer

National Institute of Mental Health
Bethesda, Maryland
Dear Dr. Meyer:

last week of

permit for
marijuana study, we prepared the enclosed protocol for study
of marijuana and tetrahydrocannabinols. This protocol has been
approved by the Chairman, Dr. Alfred M. Freedman and will be
submitted to the appropriate comittees of the College.
Following the receipt

a Federal

Hhile MH—l3358 (EEG and Human Psychopharmacology) provides
funds for the EEG aspects of this study, additional funds are
necessary and a proposed budget in the amount of $43,360 for

direct costs is enclosed.

will

be determined

appropriate indirect cost rate
we are prepared to submit
be required to undertake the study

An

administratively.

such additional data as
as a contract.

may

that supplies of marijuana. THC-A-l
and possibly THC-A~6 will be made available by your office. The
laboratory and clinical facilities are equipped to undertake this

It is

our understanding

study immediately and
Thank you

we

would request support

effective July

for your cooperation.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

Mszp

l,

1968.

�</text>
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          <element elementId="48">
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            <elementTextContainer>
              <elementText elementTextId="33413">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="102563">
                    <text>April 12, 1968
Or. Francis Latteri. Chairman
Committee on Pharmacy and Formulary

'

l East 105th Street

New

York, hen York l002‘9

Dear Dr.

Latteri:

At a meeting on April l, of the Psychopharmacology
Study Group - a committee of the Department of Psychiatry

«

four compounds were recommended for inclusion in the pharmacy.
These compounds had been requested by members of the staff.
They include flophonazino onanthata, haloperidol. thiothixene

and tybamate. The Committee‘s recommendations have been approved
by the Chairman of the Department. Dr. Alfred M. Freedman.

Fluphenazine enaothata was recommended for admission of
a new drug to the formulary. for use limited to the Department
.

of Psychiatry.

lhe other three compounds were recommended for

trial periods of 6 months and that the manufacturer be requested
to mate trial supplies available to the pharmacy.
If these recommendations are approved by the appropriate

committees of the hospital. I would be pleased to arrange with
the pharmaceutical concerns involved to make the supplies

available to the

pharmacy.

‘

Sincerely yours .
Max-Fink,

m.

Professor of Psychiatry

HF:kp

cc: Mrs. Cruzado

�</text>
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                    <text>April 10, 1968
Dr. Merle Gibson

Director ~ Division of Neuropharmacology
Office of New Drugs - Bureau of Medicine
Food and Drug Administration

Washington, D.C.

Dear Dr. Gibson:

In resoonse to suggestions of the

NIMH

that studies of

marijuana and the tetrahydrocannabinols be expanded, we would

like to undertake the studies described-in the attached protocol.

I have received Federal Tax Stamp M-l27 of the Federal
Bureau of Narcotics.

and
.

It is

my

understanding that

this is enclosed.

To avoid

a FDA—l57l should be

filed,

duplication, pennission has

received from Dr. Jerome Levine (Psychopharmacology Research
Branch, NIMH) to refer to IND 302~l, assigned to NIMH. A
letter from them to you has been requested.

been

These studies will be undertaken in the laboratories and
clinical facilities of the Division of Psychophannacology,
Department of Psychiatry, New York Medical College - Metropolitan
Hospital Medical Center by myself and the associates responsible
to me. Form l572 will be completed wherever indicated.

�Dr. Gibson

We

April 10, l968

~2-

have been assured that supplies of marijuana and the
be made available by the NIMH and/or the Federal

extracts will

Bureau of Narcotics.

This study is planned for one year, but
l8 months from its initiation.
I

may

extend over

trust the enclosed data is satisfactory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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                    <text>April 10. 1968
Dr. Jerome Levine, Chief
Psychopharmecology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase. Maryland 20203
Dear

Jerry.

I have obtained a tax stamp for marijuana studies from
the Federal Bureau of Narcotics. and am proceeding with the

F.D.A. and with Dr. Roger Meyer.

The F.D.A. has requested a letter of authorization to
pennit them to refer to your data on file (see letter enclosed).
Copies of the letters from Drs. hartin and Isbell pennitting
use of their IND are enclosed.

copy of the proposed protocol is enclosed for your
information. To provide the clinical personnel specially
required for this study, we are submitting a “contract“ request
to Dr. Roger Meyer, following suggestions received by Dr. Freedman.
A

we will be able to initiate the study in mid-May if we
receive approval from the appropriate College committees and
supplies from NIMH. For thirty trials with THC~A»1 at 300y/kg

(20 mg/dose) we will need up to 600 mg. Can this be made
from your office? Is marijuana “leaf“ available
from your office or should I call the local office of the
Federal Bureau of Hercotics?

available

'

will call your office as soon as
Thank you for your guidance.
I

I

receive approval here.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp '_

�</text>
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                    <text>April 8, l968
Dr. Samuel Bogoch
36 The Fenway

Boston, Massachusetts 022l5
Dear Dr. Bogoch:
.

Thank you very much for sending me a copy of the preliminary
announcement of the next international conference of the Sakel
Institute. You are to be congratulated on assembling such a

fine

list
I

of scientists.

would be

if

you would send such

additional

available for this meeting. as
like to attend with some of my associates.

information

would

grateful

as may become

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

I

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                    <text>April 8. 1968
Dr. Fletcher 8. Owen.
A. H. Robins Company
l407 Cummings Drive

Jr.

Richmond, Virginia 23220
Dear

0r.

Owen:

Enclosed are the forms you requested, which I understand
will be filed with the FDA.

patients are confirmed.nercotic addicts with extensive
It is difficult to know whether their reports are more
or less reliable than the.chronic schizophrenics usually studied.
The report by Shelton and-Hollister reflects studies done in
Veteran Administration patients - a group of chronic mentally
ill repeatedly hospitalized and usually inundated with psychoactive drugs. In our patients, we have symptoms reported but
I would not quote these as drug withdrawal until we have studied
Our

drug use.

this further.

These patients who have told us of using narcotics while
taking tybemote report an increase in the “narcotic high.“
do have not observed this ourselves and until we administer
heroin challenges to subjects under our observation, I would
not wish to quote this observation.

Sincerely yours,
Fink, M.D.v
Professor of Psychiatry

Mex

MFtkp

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                  <elementText elementTextId="102567">
                    <text>April 8, 1968
Dr. Jonathan 0. Cole

Superintendent

~

Boston State Hospital
Boston. MasSachusetts 02l24
,

Dear Jonathan.

invitation to discuss convulsive therapy with the

Your

residents has inspired
the citations that

me

I would

to review my files and to consider
suggest for background reading.

The best texts are those of Kalinowsky and Hoch (Somatic
Treatments in Psychiatry. Grune and Stratton, l96l) and

..

-

.

'7'

.r~--¢.m.w.-1.;,

_,,

Sargent and Slater (An Introduction to Physical Methods of
Treatment in Psychiatry. williams and Wilkins. l964).

is a list of citations which assess some of the
in convulsive therapy. The list is not
issues
important
exhausted and I have selected the article for clarity. No
Attached

effort has

been made

to

be complete.

I am sending you xerox copies of each of the
this may be useful for the residents.

Separately,

articles

and

I plan to arrive at your hospital about 10:30 a.m. and
would be pleased to spend some time with Dr. Hartmann.
Your comments about the review of EEG and drugs are cogent.
0n reureading I agree that this is too much of a summary and a
longer version should be prepared. I would like to discuss
this with you when I am in Boston.
I look forward

to seeing

you next Wednesday.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                  <elementText elementTextId="105605">
                    <text>April 8. 1968
Dr. William Tabor

A. H. Robins Company
l407 Cummings Drive

Richmond. Virginia 23220
Dear

Bill,

I have been reviewing the initial data in the elixir
butaperazine study. I cannot recall
you had indicated
have
a desire to
the
twenty cases reported in a special

if

first

format. Is there a record fonn for these cases that you

would wish us
Many

to use?

thanks.
Sincerely yours,
Fink, M.0.
Proféssor of Psychiatry

Max

MszP

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                  <elementText elementTextId="102568">
                    <text>April 8. 1968
ﬁr.

H. P. Colvin
Burroughs uellcome
l Scarsdale Rd.

Tuckahoe.

New

&amp;
'

Co., Inc.

York l0707

Dear Dr. Colvin:
We are continuing our study program of long
acting
flupnenazine enanthate (Squibb). Our experiences with the
initial 80 subjects has encouraged us to continue as the
treatment is acceptable to patients and appears to be as
effective as oral phenothiazines.

Approximately half our patients are taking antiparkinson medication and while we have recently obtained
supplies from the hospital. I would be grateful if you could
make available to us another shipment of 25000 tablets,
Kemadrin. 5 mg.

._

,

Thank you very much

far your cooperation.
[Sincerely yours,
Fink. M.B.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 8, 1968
Mrs. Nina Hethlson
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Nina,
I have

appreciated receiving the citations from the

Project. So-far, my principal criticism would be that
many articles are sent from journals which I regularly read
and this duplication may be expensive. Perhaps, in future
systens a check could be introduced not to send certain
SDI

c

tat ens.

‘

other group of citations which are of less
interest are those related principally to studies in animals.
The only

I have examined

assigned to

profile.

my
. 38 and 41 may be
applicable to my
Many

the

list

of

new concept numbers and

I would suggest

deleted. This will

present interest;

make

that

numbers

the profile more

thanks.
.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

those

la, 32,

�</text>
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                    <text>April 8, 1968
Dr. Francis

Latteri,

Chairman

Cami ttee on Pharmacy and Fomulary
l East 105th Street

New

York.

Dear Dr.

New

York

Latteri :

associates and I have reviewed the requested application for admission of a new drug to the Formulary, meclizine
My

hydrochloride.
The

literature indicates that this compound has specific
which no other compound is readily available.
is recommended.

indications for

Approval

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 2,.1968

Ir.

Thomas Lewinson

Research Division

Hoffman-LaRoche

Nutley.

New

Jersey

Dear Mr. Lewinson:
e cony of our latest report. He are encouraged
the discrimination of EEG patterns
continue
to
by this
to
of new drugs
identify their preper clinical applications.

Enclosed
work

is

grateful for copies of the reports
recently written.
I would be

you have

7

Good luck

at the

BIA

Meeting.

Sincerely yours .
Fink. M.D.
Professor of Psychiatry

Mex

Mszp

‘

�</text>
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                    <text>April 1, l968
Dr. William R. Tabor
A. H. Robins Company
1407 Cummings Drive

Richmond. Virginia 23220

Dear

Bill,'

Enclosed is a summary of a demonstration experiment with
fenfluramine (your study 2063) undertaken with second year
medical students at the New York hedical College on January 9
and 10, 1968.

-

The students participating on January 9. volunteered for the
experiment and the data is enclosed. On January lo the students
requested that the experiment not be undertaken since they were
scheduled for examinations beginning January ll. and they had
heard from the first group that some subjects had difficulty
in sleeping. For this reason only 1/4 the number of subjects
actually took the drug.
'

This was my first.experience in a student demonstration
project. For these young men_end women the anxiety of a novel
experiment, in a group setting with much interaction seemed to
so alter their responses that neither amobarbithl nor
dextroamphetamine gave a well defined response. The only
change which may be related to drug effect was the decrease in

digit

symbol score

for amobarbital.

The remaining supplies of fenfluramine are being sent. as
requested to Mr. Collins. The form for Disposition of Investigational

Drugs

is enclosed.

I want to thank you for your cooneration in
which was most enlightening. My best regards.

this study

Sincerely yours,
Pink, ”.9.
Professor of Psychiatry

Max

MF:kp

�</text>
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                  <elementText elementTextId="102573">
                    <text>April 1, 1968
Dr.

J. Hittenborn

Rutgers - The State University
Brunswick. New Jersey

New

Dear Dick.

Enclosed is the original and one xerox copy of the
Behavionaz
report "Neurophysiology of Phantastica. EEG andACNP
in
Rotations in Man.? This was presented at the

Puerto Rico and is the third for which
I

trust that this

with your approval.
who was

My

responsibie.

has not heid up pubiicetion and meets

sent
session.

I have

Chairman of the

I was

a copy

to

Dan

Freedman,

best regards.
Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Hex
MF:KP

�</text>
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                  <elementText elementTextId="102574">
                    <text>July 30. l968
Dr. Nathan B. Eddy
7055 Wilson Lane
Bethesda, Maryland 20034
Dear Dr. Eddy:
We

have

recently

been assured by Endo Laboratories

that naloxone will be available this week for clinical
study. We anticipate doing multiple challenges on each
subject and will require an additional supply of heroin
for this purpose.
Our present supply will be exhausted

August.

I would be

avmwvw'.

.

available an additional
is practicable.
Thank you

m:

an-

v

A-mW‘IJnI"

p.
t-rr

~

Mn’wm—avvu

‘u‘i‘

.
7

--,

a“"'a'—‘v'trl"mnrjrra

._.,

would arrange

to

make

grams of heroin as soon as

for your help.

Fink, M.D.
Professor of Psychiatry

Max

V:w.._..,_,.,,.,,.a

.m—wu

if you

5

end of

Sincerely yours.

,,.,

mar—.7“...

grateful

at the

MF:kp

�</text>
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                    <text>July 23, l968
Dr. Nathan S. Kline

Director of Research
Rockland State Hospital

Orangeburg,

New York

Dear Hate,
Thank you very much

for the lecture to the residents.

Enclosed is a small honorarium.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>July 23, l968
Dr. G. B. Blane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons. Ltd.

Hull. England

Dear Dr. Blane:

of the MAS-NRC Committee
just read the l968 report
reference to the
on Problems of Drug Dependence and note
meeting,
narcotic antagonist M-SDSO. As we presented atin that
treatment
the
we are particularly interested in antagonists
I have

of opiate dependence.

data is
Has M-SOSO been assessed in human trials? If the
we
are particularly
available, I would appreciate a citation. since

interested in its duration of action.

are supplies available for
If it has not been assessed,
clinical trial or will they be available in the near future?

are interested in making such assessment if supplies
with
could be made available. since we already have experience
cyclazocine and naloxone.
Sincerely yours,
We

Fink. M.D.
Professor of Psychiatry

Max

mf:kp

�</text>
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                    <text>July 22, l968
Mr. John

J. Bellizzi, Director

Dear Mr.

Bellizzi:

Bureau of Narcotic Control
855 Central Avenue
Albany. New York 12206

is a copy of our Federal Tax Stamp. Class 5 4 and 5 narcotics. The suggestion in your
June 21, that we apply for a class 6 (marijuana)

Enclosed

marijuana and

letter of

does not apply to us since

we

are not millers.

I trust that these registration stamps are sufficient
to comply with the regulations.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>v—wq.':WmF-.

.

«mwﬂ-‘qw

~7un-

.

v'quw'

ran-n

July 19. 1968
Hr. Nathan F. Williams
The Blue Line Chemical Company
302 South Broadway
St. Louis, Missouri 63102
Dear Mr..Williams:

Following our discussions today I am writing to request
your estimate for supplying 50 one liter sterile bottles of
one-half molar sodium lactate. After discussion with the
author of the enclosed paper, Dr. Pttta, the calcium chloride
is not prepared ahead of time, but will be added here. We,
therefore, need only the one-half molar sodium lactate.
Enclosed is a copy of the report.
our reference.
Thank you

Please see page

for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mix

two

for

w.mn—

�</text>
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                    <text>July 19, 1968
Dr. Alan E. Smith
Duputy Director

Division of Anti~infectiv¢ Drugs
Office of Now Drugs
Bureau of Medicine
Food and Drug Administration
ﬂushington, D.C. 20204
Dear Dr. Smith:
The

RE:

IND 2822

studies of cycloaarina, with or without

Dilnntin
undertaken at the University of Missouri were couyleted
in
the

winter of 1965. Unfortunately, I moved from
in May of 1966 and have not had an opportunity to Missouri
summarize
the information. I have contacted one of my associates
and asked that the data be summorizod.
The

study was discontinued in the winter of

1965 and

each of the investigators were notified. The unused
supplies
of cyclosorine were diocarded.in Missouri and are
no longer
available.

Sincoroly yours,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>~

July 19,'1968
Dr. Merle L. Gibson
Acting Director
Division of Neuropharmacological Drugs

Office of New Drugs
Bureau of Medicine
Food and Drug Administration

washington, D.C. 20204
Dear Merle,

I want to thank you for the cooperation which you have
expressed on behalf of the FDA to Endo Laboratories regarding
naloxone. In a meeting with one of their vice presidents
last week, we were assured that supplies of naloxone would be
made available for clinical trial early in August.
I

writing to ask your advice on another matter. In
investigated the effects of intravenous procyclidine
in patients receiving convulsﬁye therapy.' Recently
in response
to suggestions from NINE, I have reestablished a study program
am

1956~58 I

in convulsive therapy. It seems advisable to repeat some of
the observations made earlier and to build on that
With this in mind, I called Burroughs Wellcome and experience.
requested
a supply of parenteral procyclidine, since such is not listed
in the PDR. Dr. William Calvin indicated that the IND for
parenteral procyclidine was withdrawn and supplies of parenteral
procyclidine were no longer available but could be produced.
When I asked that he do
so, at our expense, he indicated that
this was not possible insofar as the IND had been withdrawn.
are the steps necessary for me to meet existing FDA
and to permit Burroughs Wellcome to supply parenteral
procyclidine for experimental use in a project approved by the
appropriate authorities of the college, NIMH and the City of
What

regulations

New

York.

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

.

»,~—.-7,.,,,,

va—

�</text>
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                    <text>July 19, 1968
Dr.

Ferris

N.

Pitta, Jr.

Department of Psychiatry
Renard Hospital
$940 Audubon

St. Louis, Missouri 63110

Pitts:

Dear Dr.

pleasure talking to you today and in the few
minutes of our discussion, I am sure you saved us three months
of work.

It

was a

are anxious to replicate your study and would be
grateful for an initial supply of onenhalf molar sodium
We

lactate.

discussion highlighted the many details of this
study which cannot appear in print. would you be willing
to have a member of my staff visit you and observe the
actual administratiOn of these solutions and the details
of the experiment? I would like to send Dr. Michael Taylor
who is a third year resident undertaking this study.
Our

Incidentally, I will

August 12-13 and

if

we

be in St. Louis on Mbnday or Tuesday.
can arrange a demonstration at that time,

then I can attend as well.
Many

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>.

:2‘

.Yw

-

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we.

was“... “aw—g.

mam...r..r-qp.~u

v,‘&lt;’vw

vvu'v‘u» ..,;w-‘.-:~ ~.....nw.m.

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July 18. l968
Dr. Alain Sanseigne
Squibb International
460 Park Avenue
New York. New York
Dear Alain,
I enjoyed lunch very much and I hope that
under such pleasant circumstances more often.

in

Enclosed is

"A

we

can meet

Selected Bibliography of Electroencephalography

Psychopharmacology" which was published in 1964.

Human

It

is the definitive supplement to the first bibliography wtitten

by Mary Brazier and covering the period l936-50.

of Phogeeaa in Baain Reacaaeh.
This
was organized by Phillip
symposium
”Anticholinergic Drugs.“
and myself and the major portion of the editing of documents was
undertaken in my office. This symposium was the second which I
organized on the same subject. The first is published as part of
volume Advances in Biologioaz Paychiateg edited by Joseph Hortis,
the
966.
I am

also enclosing

Volume 28

interested in the tremendous value of
depot phenothiazine therapy, not only in treating chronic mentally
ill but in relieving acutely disturbed patients in a community
mental health center. If I can made a contribution to this
subject by assisting in the publication of the available data.
As

you know, I am

I would be
My

pleased to do so.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp
one o

7”

�</text>
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                    <text>Juiy 18.

1968

Dr. Alfred M. Freedman
Chairman of the Department

Department of Psychiatry
York Medics! Coiiege

New

5

East

New

102nd

York,

New

Street

York 10029

Dear A1,
I am pleased to send you this volume
“Antichoiinergic
Drugs” recently puhiished by Elsevier. This
was
heid in 1966 but most of the editing was done symposium
in New York.
My

thanks again

far your support.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>awn-mu».

~.Jv“'&gt;'.1'"nr,wv

vim].

.,.-.-_~

.—

..
w ma n max,'wr rx w w v..- . —:~(:.n-. '1' m-v- Wm nun-I“.
W‘wa a-wrw-u‘uninn-IVAan‘I'Vwmru'ﬂw'vaW-eanw"“wart-'0’”
.

V

,

“we“;

v

.._

_

July 18,

1968

Dr. Charles Shagass

Eastern Pennsylvania Psychiatric Institute

Henry Ave. and Abbottsford Road
Philadelphia. Pennsylvania 19129
Dear

Charlie,

of the work reported in this volume would not
have been accomplished without your faith and support.
Please accept this copy as a token of my esteem.
Much

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
CDC

.

�</text>
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                    <text>July l8,

1968

Dr. William Guy
George Washington University

Biometric Laboratory

6l8
ll45 Nineteenth Street, N.".

Room

Washington. 0.C. 20036
Bear

Bill,
Separately I

sending you the additional forms for
our ketimipramine (060l0) and butaperazine (06007) studies.
am

recently received one box of the
global scales. No second box was received.
We

have

We

are now using
that you send

and ask

September.

CG!

(l2)

form 03 (treatment emergent symptoms)
us 200 now and 200 additional in mid-

May we also have 200 copies of the Hamilton Scale (form 08)
and an additional 100 of form 12.

Sincerely yours,
Max

Fink,

M.D.

Profestor of Psychiatry

Mszp

�</text>
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                    <text>M‘qpﬂii'

.7... mm

--—.m,n..ur-m

w&gt;nm Jun awnmf, uuw

.-

,

-

.Wl-‘Wr,

M‘va

worm—wwu u.» ,_n
,

,

,,,,.
,.

.

m F I, ”,4
.
”no ,u. _...ww “WNW—.... /,-_£
r
»

.

.
4

"any

w-vn-VW-nwwar

WW

July l8, 1968
Dr. Lothar B. Kalinowsky
ll5 East 82nd Street
New York, New York l0028
Dear Lothar,

Please accept this copy of "Anticholinergic Drugs."
This symposium was presented in Washington in l966 and
it represents a useful portrayal of our available knowledge.
from

The
NIMH

convulsive therapy project has received support
and I look forward to our continued collaboration.

Thank you

for your assistance.

My

best regards.

Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp
ENC .

. e ,Hg a ...“...—,

”w
.

-..1.--

1.1-

i.qw Lpglg“v‘

.-x.

-r

.

r-‘iz-zvn

..;,.

�</text>
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                    <text>July l8, l968
Dr. Robert L. Kahn

Associate Professor
Department of Psychiatry
University of Chicago Hospitals and Clinics
950 East 59th Street

Illinois

Chicago,

60637

Dear Bob.
The program of research in convulsive therapy is now
in Gracie Square Hospital. 1 have two resident
progress
physio ans working with me and a fine experimental psychologist.

in

I would like an opportunity to have you meet with my
staff and to discuss their programs. Do you expect to be
in New York within the next two months? If not, would you
like to come on a visit and we will defray the necessary

expenses.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July l8,

1968

Dr. Samuel Irwin
Professor of Pharmacology

Department of Psychiatry
University of Oregon Medical School
3l8l s.w. Sam Jackson Park Road
Portland. Oregon 97201
Dear Sam.
Your nephew has been working with me for more than onehtlf year and I want to thank you for sending him. He has
learned rapidly and is an asset to our program.
I plan

to be in Portland forea drug problem

session on August l4~15.

I

will probably arrive

and would welcome an opportunity to meet with you
evening of the l3th or on the l5th.
I may

bring Peter to keep

him

summer school

on the

either the

out of mischief.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

l3th

�</text>
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                    <text>July 18.

1968

Dr. Joseph Zubin
722 West l68th Street
New York, New York l0032
Dear

Joe,
Thank you

for the

copy of the

APPA

program.

My nomination for the Hoch Award is Martin Roth of
Newcastle. For at least two decades he has been a leading
figure in attempting clarification of psychopathology. He
has written on a broad spectrum of subjects and in this

regard is quite similar to Paul Hoch.

Sincerely yours.
Fink,
Secretary

Max

MF:kp

M.D.

�</text>
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                    <text>July l8. l968
Dr. Paul Blachly

Associate Professor
University of Oregon Medical School
3l81

5.“.

Sam

Jackson Park Road

Portland, Oregon 9720l
Dear Paul,

for your kind invitation to participate in
the summer school. I know that you will be busy, but if
you are planning to treat patients any day that week other
than Wednesday, I would like to make arrangements to be in
Portland to, once again, watch the treatment administration.
Thank you

I

look forward to seeing you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>w «hr—"varn-

,

4.3.2:

7..

wnw—Wuvv-wvo—mr

wwvunmhwm~www-wu

'

nu..-

w-m

“Wm!"wmm'

.7

w m,

.V'x-n—E‘QWvn,

July 17, 1968
Mr. Herman S. Heisman

Senior Reeearch Associate

HoffmanneLe Roche. Inc.
Hurley, New Jersey 07110
Dear Mr. Heisman:
my

associates

and a revised capy

review

and

I have reviewed the pronosed protocol

is enclosed.

this, please call

laboratory.

my

When

secretary

you have had a chance to
and arrange to visit the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 16, 1968

J. Robinson
Hoffman-La Roche, Inc.

Dr. R.

Nutley,

New

Jersey 07ll0

Dear Dr. Robinson:

It was a pleasure to visit your laboratories, and I am
most grateful for the courtesy and attention shown me by
Dr. Whitman and his associates. I am impressed with the
was of value to me to meet Dr. Schallek and
programs and
see his program in action. The EEG methods of analysis of
psychoactive drugs for applications in man has been of
Special interest to me. and I will review the data of
R0 5-3350 with the probability of undertaking a neurophysiological profile analysis in normal volunteers. We
are prepared to cooperate with Dr. Schallek in the analysis of
some of his data should he wish to do so.

it

it is

taking advantage of our short acquantance,
a ridiculous problem which you and the
laboratories at Hoffman-La Roche may be of assistance. The
neurophysiology of narcotics has become a recent interest,
and the problem of marijuana and tetrahydrocannabinols has
been an open question since the first studies of Williams et‘gl.,
in l946. We are equipped to do detailed analyses in man, But
have been unable to obtain a legal source of marijuana or THC.
The recent report of Schekel and his associates indicates that
but

THC

Perhaps

I am

faced with

was produced by your

laboratories.

consider the production of THC for our use?
the necessary Federal and state permits for testing
and handling marijuana; an IND from the FDA; and protocols
for studies have been approved by the appropriate committees
of the medical school and by the Commissioner of Hospitals
of New York.
Would you

He haVe

�v
Dr. R.

J.

Robinson

-2-

July l6,

1968

If such a production is possible. I would be anxious to
discuss the costs and the necessary clearances from the appronriate
Federal authorities with you.
A

recent review of the studies of

for your information.

EEG

and drugs

is enclosed

Many thanks for your consideration and again, for the many
kindnesees of your staff.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

cc: Dr.

E. Whitman

Dr. C. Scheckel
Dr. A. M. Freedman

enc.

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                    <text>July 16,

1968

Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego. California 92l52

Dear Ardie,

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

to read it. since I have just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory, exce t that there are
additional tables such as you request spage l6§ describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication. but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.

difficulties

which you describe - difficulties which are described
this approach. and also found by ourselves - are
the lack of discrimination of small differences in this method.

The

by others trying

Perhaps the lack of discrimination is related to the paucity of
samples for study ~ if I understand, you analyzed l8 selected
minutes of an all night sleep recording. This small sample is
related to the cost of power spectrum.

That PNRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REH and stgge 3 from stages 2 and 4 are the same
problems we faced in power spectrum. Additional discriminations
are possible in period analysis. for the stage I - stage I-REM
discrimination is now available; the stage 3 discrimination is
feasible following your suggestions (page l8) and some of our own.

�Dr. Lub1n

Ju1y 16, 1968

-2—

Some of the
I agree w1th your conc1us1ons (page 17).
recommended add1t1ona1 data 13 ava11ab1e or 15 read11y
programmab1e us1ng per1od ana1yt1c and the d1stance funct1on

‘

approaches.

Perhaps the t1me has come to compare the ava11ab1e methods
for systemat1ca11y co11ected data. As I 1nd1cated ear11er, we
are prepared to ana1yze tapes us1ng the per1od ana1yt1c methods.
We wou1d be spec1a11y 1nterested 1f they are a1so to be ana1yzed
by)our methods. The costs 1n do11ars and t1me are negot1ab1e
and shou1d compare favorab1y w1th the expense and delays wh1ch
you descr1bed for your present systems.
Such ana1yses cou1d be done as part of a demonstrat1on for
an APSS meet1ng and as the bas1s for a d1scuss1on of the ava11ab1e
methods. If th1s is not feas1b1e, we wou1d st111 be w1111ng to
cons1der a demonstrat1on for you at a cost that 15 comparab1e to

that of Astropower.

It was a p1easure to hear your report 1n Wash1ngton, and to
read th1s prepr1nt. Perhaps the enc1osed report W111 perm1t you
to be more opt1m1st1c about th1s rea1—t1me (or 2-4x rea1 t1me)
ana1yt1c system for the re11ab1e and automat1c scor1ng of EEG
sleep stages.
My

best regards.
S1ncere1y yours,
/ﬂax F1nk,

M. D.

Professor of Psych1atry

Mszp

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