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                    <text>May 8, 1990

Richard Josiassen, Ph.D.
Department of Psychiatry
Medical College of Pennsylvania
3200 Henry Avenue
Philadelphia, PA 19129
Dear Richard,
Your questions are most intriguing, and hasten to argue my
idiosyncratic views against the present drive to the study of anatomic structure
as a basis for psychopathology. Since you limit the query to the past 25 years, I
am precluded from arguing that the seminal studies of the century remain those
of Wagner-Jauregg, Meduna, Weinstein and Kahn, Wikler and Martin. In the
period requested, the most impressive studies have been those of Taylor and
Abrams in identifying the syndrome of catatonia as associated as much with
affective disorder as with schizophrenia (which effectively vitiated the logic of
DSM-lll); the genetic identical twin studies in London which found both
schizophrenia and affective disorder among genetically identical siblings (which
effectively discredited the present genetic studies); and which led to the unitary
hypothesis of psychosis of Timothy Crow.
I

would credit Shagass with the best of
modern patient classification devices, the sedation threshold; DeWied and
others for discerning that brain peptides have behavioral effects; and the work
of the unheralded chemists who developed naloxone, providing the basis for a
life-saving technique in clinical medicine.
From psychopharmacology,

I

Your second query is even more intriguing. can more easily answer
the question about the two or three most damaging hypotheses underlying the
biological understanding of psychopathology. For example, the belief held by
many in neuroscience (and the ACNP and NIMH as well) that studies of rat
brains will lead to an understanding of psychopathology is clearly wrong. Rats
are not men; rat physiology and pharmacology is readily distinguishable from
that of man. Further, normal man is not the same as sick man, since it is the
differences induced by illness that are the basis for our interest. Similarly, it is
silly to assume that studies of the normal rat bear any relation to mentally sick
I

man.

�the same vein, the genetic and structural hypotheses of
psychopathology are old theories, espoused in the 19th century, and probably
as wrong now as they were then, albeit we have better ways to picture the
structures of the brain.
In

were to argue for the hypotheses that are outside the mainstream,
that may lead to an understanding of the bases of psychopathology in brain
function, would point to that model of psychopathology which argues (from the
diabetes and neurosyphilis experiences) that the expression of psychopathology
is the end product of a stressor (g9, spirochaete or hypo-insulinemia) and its
interaction in a psychological substrate (ggq ego and superego; or character
and personality; or memory and emotional patterns as modified by life
If

I

I

expeﬁence)

This view is best stated as the unitary hypothesis of psychosis. The
best example of this view is the case for catatonia (primary and secondary;
malignant and NMS) as a general brain disorder not part of schizophrenia, and
one that is highly responsive to ECT. That some patients with dementia praecox
exhibit signs of catatonia is not unlikely, given the high probability that catatonia
is an endocrine deficiency disorder.

Another support comes from observations that ECT is equally
effective in treating mania and depression, with or without psychosis, with or
without melancholia, with or without catatonia; with or without dementia
(’pseudodementia’). This varied effectiveness is often cited as an example of the
’dirty’ nature of ECT; view it rather as an example of the specificity of ECT and
the ’dirty’ nature of our psychopathology. (Recall the varieties of neurosyphilis in
this context.)
I

These views are outside the mainstream. That

is why I continue to be
intrigued by them, since I ’know’ (from history), that the pack is usually wrong.
And the present neuroscience pack is surely wrong since few, if any, have any

experience

If

in

the clinic.

you wish a concise view of catatonia, urge you to read the recent
I

review by Taylor in NNPBN.

best regards to Charlie, whose work with the sedation threshold
have long admired, but still cannot comprehend.
My

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

l

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                    <text>.7, WW n.

»'I“&lt;-u

m. w rw-v, 1-H

,_.,

Y«r;4r4u ".‘B"VFWI«V21|"1

an”, ..-W~,,~-»4,yn“’12“m»“.

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a

mug-'—

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v,r.~.,.rr,m. n...“

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January 27, 1971

\-'”‘.'—‘rurwlwr

“my

w.

.

,
7
4w

T—y

a
h"

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ww

”WM".

mmkﬂwnwﬂ‘t'vl'v‘mmv'ﬂ‘."

wmwvr

Dr. C11fford Joseph
Department of Medica1 Research

Hoffmann-LaRoche, Inc.
New Jersey 07110

Nut1ey,

Dear Dr. Joseph:
I have received the 11terature survey of the effects of 1evoDona on s1eep and EEG. Mr. Ryby presented me with at 1east six

re1evant c1tations that were very usefu1.

our

As
own

soon as I have an acceptab1e protoco1

quant1tat1ve study.

Many

thanks!

1

W111

try to undertake

Sincere1y yours,

Fink, M.D.
Professor of Psychiatry

Max

MFtkt

cc:

Mr. Neissman

K.

_

v.—

, .v..,, .

V

7.,

�</text>
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                    <text>February 6, 1968

Jostrand
Corporation

Mr. Mayne
IBM

211 Montague

Brooklyn.

New

Street

York 11201

Dear Mr. Jostrand:

that unless the
defined
there
computer is clearly

months ago I reminded Bob Shearman

Many

billing for the
will be continuous bookkeeping
The

IBH 1800

bills

hold

are addressed to Dr.
5th Avenue

IBM

Max

difficulties.

reference 64762-06. 083081. These
Fink at the New York Medical College,

at 106th Street.

.

it

does not define the
This is unsatisfactory since
unit as separate from other units within the medical complex.
Would you

please ask your bookkeeping office to send a

all invoices for 1967 to me and arrange to have the
account readdressed as installed at the Department of Psychiatry,
New York Medical College, 5 East 102nd Street (8th floor).
copy of
New

York 10029.

Also mark the invoice to the same location.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

�</text>
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Dr. Wayne Jostrand
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Dr. Jostrand:
would appreciate a quotation from
purchase of our installed 1800 system.
We

IBM

for the

Thank you very much.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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September 20, l968
Dr. Wayne Jostrand
IBM Corp.
475 Northern Blvd.
Great Neck, New York
Dear Wayne,

to thank you for arranging for my visit to the
Center in Palo Alto. Rich Hunaate was a very co-

I want
ACME

operative guide. I was able to discuss the report briefly
at the Computer Committee yesterday and perhaps. in the not
to distant future, will be looking to expand our core.
for

When

me.

next you write to Mr. Hungate, please thank him

Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

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                    <text>July 15. 1969

lg”
41s

Hm

Joni-nod

am.
WornHow
York

Great

m.

bur Rune.

. no have had difficulty
n
After my verbal
iotioo.
inst:

ks we have repeatedly

-

with our moo since its
complaints. we took tho. extraordinary procedure of oi'i'iciauy
writing to you.
This «mod to produce results so that for the put those
few breakdown and reasonably notiofoctory
Mimi:co.u: have but

u

m1: is to indicate to you that this =mhioory has not

boon functioning since July 1. that each and every one of
12 disks have boon scrub!“ so that
will inquire at tout
fu‘l'i
those
two
programs.
day: to restructure
om to

it

fowsuo no the disk drim and I would
om
mount your imdiou attention. I would trust that you will
The problem

give as credit for we route! costs siooo July 1. since that
on tho undontooding with which we continued our niotiooship.
Sinceroiy yours.
Fink. «.0.
m
Professor of Psychiatry
H152”)

cc: Mr. T. Blower
Mr. T.

J.

Notion

�</text>
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                    <text>January
Dr. Wayne

53.

22 , 197!)

Jostrmd

Marketing Roprosontntlvo
Data Processing Division
475 Northern Blvd.
Great Rock, New York new
ﬂoor

Wayne ,

For three years we have been renting an In”. 1890,
assembled at 5 East 1023:! Stroet, under your Invoice 330. #287722.
This equipment was paid for by a grant award from the National
Institutes of Mental Health to the New York Medical College.
This award expires March 31, 1971.
I“'«7;»'4aaaj~mm'«wrn=m‘m¢~wK

NW

‘

.

In order to continue support, we must apply before Juno 1,
We wish to purchase the equipment listed on our invoice,
1970.
now installed at this location on Avril 1, 1971. Would you please
obtain a quotation for purchase on that date?
We

will also

ask

for a quotation of the charges for maintenance
April 1, 1971, so that

of the equipment on an annual basis, offectivo
we can make the necessary applications.

Sincerely yours ,
Max

Pink, 54.3.

Professor of Psychiatry

M? :kp

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                    <text>kW

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                    <text>April 26, 1967

Editor

American Medical Association
Joml
535 North Dearborn Street

of the

Chicago,

.

Illinois

60610

Dear Sir:
Enclosed are two copies of the report "long-Acting,

ththiazine Tmatnent of Psychosis," for your
omside'mtion for mblicatiOn in the Jamal 06 the Ame/(Loan

Depot

Abdomen, in either the section of original
MW
contributions
in the section of "clinical
or

notes.

All commioations should be addressed to the

signed.

Thank you

writer--

for your consideration.
Sincerely. yours,
Fink, mm
Professor of Psychiatry

Max

211‘sz

‘

cc; Dr. Keskimr

‘

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                    <text>Fwy“ WP-nw-w'vvrn-«vmmw-Wwvﬂl m—Jv:

_

xv

_ ...,

.

‘

_

an“

~.,

._ ‘ ' '_ ‘

w”

,

'

,_

v

,

.

r

_

“N,

..

V

,

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-..

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A

A.
V

.
,.
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.7

V.

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i
n.

7

A

...

,

.

January 15, 1971

-...—.....W...-.v

Editor

JAMA
.,.—w.-w-.v—ma.wuw~m—

535 N. Dearborn Ave.

Chicago,

Dear

Illinois

60610

Sir:
I

was

interested in the report in International

Comments

of November 23 (213: 1572) that confiscated cannabis in Germany
was equivalent to 2,278,170 kg in 1969. On inquiry, you kindly
sent me a copy of the original report, "Informationsdienst der
Bayerischen Landesarztekammer in Munchen” of August 21, 1970.
In reading page 2, I now understand the source of the data,
but suggest that in translation an error has been made. The
report reads:
Cannabis

1968

1969

380,924 kg

2

278,170 kg

It is the European practice to use the comma in decimal numbers
where we use the period. I would read the amounts as 380.924
and 2,278.17 kilograms, equivalent to 838 and 5,012 pounds. The
other numbers are more reasonable, i.e., 587,479 grams, read
as 587.479 grams equivalent to 0.59 kilograms, or about a pound.
A recent
report of U.S. seizures is enclosed to put the issues
in perspective.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

E

MFrkt

vmawwm

�</text>
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                    <text>EdiTor,

OcTober
JAMA

3i, |97i

American Medical AssociaTion

Chicago,

illinois

Sir:
i am
wriTing in reference To The reporT by The AMA Council
on MenTal HealTh, "NarcoTics and Medical PracTice" in The issue of
OcTober 25. While The reporT repeaTs The convenTionai expressions of
earlier reporTs, There are Two faceTs of The TreaTmenT of oplaTe
dependence of The meophine Type ThaT are presenTed so poorly as To
warranT commenT.

AfTer agreeing ThaT meThadone mainTenance is a logical

procedure for communiTy agencies, The CommiTTee recommends This
TreaTmenT as noT feasible for office prachce, noTing ThaT The individual
physician ". . . cannoT provide all of The services for The various
TherapeuTic needs of The paTienT." As i know of no evidence ThaT
meThadone mainTenance is therapeutic, nor of any evidence ThaT some
'TherapeuTic services' affecT The course of The disorder in subjecTs
receiving meThadone as Their primary TreaTmenT. Could iT be, ThaT The
Council is once again presenTing ex cathedra opinions based on no
evidence, To suiy some public needs or prejudices ? Would iT noT
be more honesT To suggesT ThaT The fear of illiciT disTribuTion of
meThadone puTs The AMA Council on The side of limiTed disTrlbuTion,
and if ways could be found To use physicians wiThouT seepage, ThaT
This would be as saTisfacTory as any oTher means of dlsTribuTion
ThaT provided medlcaTlon wiThouT seepage ?
A second issue is ThaT The secTion on research repeaTs The
sTaTemenTs of years pasT, wlThouT acknowledgemenT ThaT some progress
has been made in Two areas- The use of narcoTic anTagonisTs of The
specific Type (see JAMA, 202:l9l—l94, i967; ibid, 215:2l08-2ll0,i97i;
Science, 169: i005-l006, l970) and in The conTagbous Theory of opiaTe
dependence— The laTTer providing an alTernaTe Theory To The convenTionai
'bad psyche' Theory implied in The CommlTTee's recommendaTions.

There are oTher discrepancies wiTh experience which suggesT
ThaT The Council has noT Taken lTs charge seriously.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

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                    <text>October 31, 1971
Dr. U.

J. Jovanovic

Universitats-Hervenklinik u. Poliklinik

Fuchsleinstrasse 15

87 Wurxburg, Germany

Dear Dr. Jovanovic,
symposium,

to

New

York

Enclosed

is a copy of my presentation at the recent
of Sleep". I regret the delay but I did not return

"The Nature

until

mid October.

very much enjoyed the meeting, and wcmt to take this
I
to
opportunity
congratulate you on a fine meeting, well organised and
well run. Most interesting for me, was the occasion to meet many of your
co—workers and to realize that in a few years you have created a most
productive research group. I look forward to the results of your labors
in the scientific press with interest and optimism.
My

best regards, and

my

thanks

for your kind invitation.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

�</text>
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                    <text>Dr. U.

J. Jovanovic,

April 18, 1971

M.D.

Universitﬂts Nervenklinik u. Poliklinik

WUrzburg, west Germany
Dear Dr. Jovsnovic,

Thank you for your kind invitation to participate in the
fothhcoming symposium, The Nature of'SZeep, in Wﬂrzburg, September
23~27, 1971. I am pleased to accept your invitation to chair one of

the sessions, and believe I can

I:
II:

an.

m‘vg'V-‘g'lv‘grv‘y'l‘

(Probleme der apparativen Auswertung); and
(Anderungen 1m Schlaf-EEG unter Wirkung
von Psychopharmaka) and item 45 (Kompsration der Einwirkungen von
Schlafmittel und Psychopharmaka). I would be prepared to comment in
either session from my studies.

item

.

3'
’-‘,v“’t-,1

4:.

5

37

I can also prepare a more formal presentation for the
session in item 45, under the title:

Quantitative EEG Classification of'Psychoactive

g.

"'-1?’3W

or

Psychopharmakologie (17.

in (V), particularly items

&lt;

contribution to either:

Mkthodén and Teohnik der Uhtersuahungen,

(I), particularly

In

a-

make a

Drugs

in

Man.

I look forward to the symposium, and am honored to participate.
confident the proceedings will make a valuable contribution to
the physiology of sleep.

I

am

Good luck

!

Wenmwwwnmart

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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:I;

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r

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September 17, 1971
PD

Dr. U.

J. Jovanovic

Universitats‘Nervenklinik u. Polyklinik

87 Wurzburg
West Germany

Dear Dr. Jovenovic,
York on Pan Am Flight 100 on
Wednesday morning, September 22, arriving Frankfurt at
11:59 p.m. Wednesday evening. You have arranged for me to
stay at the Hotel Rebstock, and I would be grateful if you
would notify the hotel of my late arrival, and arrange

I plan to leave

transportation

New

if that is still feasible.

I look forward to the conference with enthusiasm.

“Wary“,vzﬂ:

‘wr'n-

2"

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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W
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m. Vim-ht A. Joy

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York 18022

Joy:

Hymaooiau, Dr.

hmltil. «ﬂamimityof

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WIbclieve
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form 111W.

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m:

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Professor of

Why

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Dr. Vincent A. Joy

Director, Clinical Research
Squibb International
uao Park Avenue
York. New York 10022

New

Dear Dr. Joy:

for the kind note from Dr. Daniel. Unfortunately,
forthe
Iwillnotbegoingtolondmattheezﬂofthismnth,
will be made by Dr. Heedman.
presentation
Thank you

have canpleted the penultimate draft of the report on
fluphenazine decarmte. The final draft should be available
We

withintmweeksandeillbepleasedtosendymcopies,
both for your own information and for Dr. Daniel - for it is
this information

to discuss.
IfIaminemrandDr. Danielwislnstodiscussanother
matter, I will be pleased to hear from him.
which he may very much wish

szbuldmoeiveacopybytheendofﬂarch.

for your interest.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfﬂq)

Thankym

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                    <text>May 5 , 1967

Dr. Vincent A. Joy

Director, Clinical Research
Squibb International
lH50

New

Park Avenue
York, New York 10022

Dear Dr. Joy:

I

Enclosed are two copies of our fluphenazine report.
if you mld send one to Dr. Daniels,

would be pleased

as reflected in your

letter of March

3, 1967.

I trust this is helpful.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Mszp

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géutmt 10!
Pam WWW a! 1m Wm
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m;
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.

�</text>
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w,,_l_w__,.,.,_.,,.. ,,.,.n‘.,__—.,.._~,.._ “mu...“ m... vg)‘-nlrayWvanuuW0r~-p:-

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w~.m.~..a.n

10.

in "an: W~"v"

«3-:

Wm; '.\"War—V "WW-'YmW-Iv

1955

DearDr. Ibor:
The psydaiau’ists in this Departmnt of Paydﬁntry
am intmtud in participating in the 1966 World Congas
of Psymiatry. I vault! be grateful bf you amid send m
such information as my, frat: tim to
available

regarding program

cm

th, hm

maismatiom for this meeting.
Sincerely
Max

Mfsjm

yam .

Fink. NJ).
Paydﬁatry

Mauser of

v-vaw 'w:m~ w"

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                    <text>October 27, 1969

Professor Karolina Jus, M.D.
Klinika Psychiatryczna A.M.

ul. Nowowiejska 27
Warsaw, Poland
Dear Dr. Jus:

letter that I have just sent
that you or Andrzej can give
help
to
to this mission will be appreciated.
Enclosed

is a

Dr. Denis Leigh.

copy of a
Any

I very much enjoyed your

seeing you again.

visit here

and look forward

to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF2kp

'

we‘m‘

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                    <text>w."

w' w:1-'W"‘7W

‘~.~m.—w—.. a» ﬂaw".www-Iwnumr

munxm.

-...

~

,
.3.” "kw..."

W'WV‘W'V'

.« .wl'VF'C

.

n mum—v...,n—w—mw
,

”waver—WWW

mm..-

——n~&lt;~

December 11, 1069
Dr. Karolina Jus
Akademia Medyczna

w

Warszawie

Klinika Psychiatryczna

Warsaw, Poland
Dear Karolina,

Your kind letter was received on my return from Mexico.
I was pleased that you did recommend a section on BBC and
psychiatry for the WPA, but I regret to tell you that such
a suggestion has not been accepted. In Mexico, I met with
Dr. Ramon de la Fuente, secretary for the Mexico City meeting,
who had just returned from London. He said that more than
20 groups requested separate sections, and that the WPA
Committee selected those they thought were relevant and

important.

inquired as to whether they would assist us to
hold a separate meeting in association with the World Congress,
Dr. de la Fuente became visibly upset and indicated, that while
he could not prevent our meeting, he would neither incourage
nor assist us.
When I

Andrzej is visiting with us these days, and I trust will
able
be
to report both on the wonderful time in Mexico City,
and the progress in our laboratories.
My

best wishes for a prosperous

1970!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

V

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                    <text>Rovember 8, 1972

Dr. Gordon

Jueter

ReurOpeychiatric Evaluation Unit
Yale~ﬁew Keven Hospital

inertial

New

Unit - 10 Heat
Haven. Connecticut 06504

Dear Dr.

Jester:

the request of
experiences with him.
At

Mr. Joseph

Reylor,

VG

are

amusing

our

volunteered for e series of experiments in which subjects
receive, at weekly intervele, single orel dose: of psychoactive druge.
The dosages are selected as "threshold" ~ the minimum
necessary to
He

elicit behavioral or

verbal behavior.

EEG,

physiOIOgic

heart rate,

effects.

The

and mental

recording includes

status. Volunteers are

males, over 21 years of age, with e history of drug use (usually cannebis and hellucinogens).
goal of the study ie to define the
correletione of psychoactive drugs.
The

Mr. Baylor

have n normal EEG.
dicated no symptoee
He

EEG

and beheviorel

volunteered on April 12. 1971 end wee found to
A screening interview we: unremarkable; he
inor treatment suggestive of mental illness.

bed an adaptation experiment in which he received e plecebo.

On April 22, May 6. May 13, end May 20. 1971 he received
four coepounde; dieeepee 10 mg., placebo end two new beneodieeepenes
related to diexepem. During each session, ﬁnd in the poet eeseion
period ee reported the next day, be exhibited the usual symptoms of
mild sedation. From the self reports, it was not possible to separate
active drugs from placebo, although the EEG recordings were distinguishable.

�Dr. Gordon

Jueter

Hovember 8. 1972

efter the last session, he called to say
reported thet he had been involved in an
accident a day after the third EEG aaaaion. and insisted on knowing
the nature of the drug given. The cane information described before
the experiment was described again, and he was told that the sessions
included placebo. A physician we: not available the day he visited,
and he was asked to return the next day; but he did not.
Sir

he did not

weaka (7/9/71)

feel well.

He

On July 31. 1972 (after one year) he came spontaneously to
the study unit and was seen by a physician, who noted that Mr. Raylor
complained of headaches, intolerance of heat. feeling dazed, meleiSe
and trouble with concentration. Also he reported "electrical static
sounds from inside my head". The physician found him anxious, eoee~
what diahevelled. and perueveriug about the question of drug: causing

his symptona.
Be

inaiated again on knowing more about the drugs given him,
told about the general nature of the compounds, their

and again he was

sedative qualities, egg.

he did not seem

to accept this reassurance.

The new compounds used in the study were given to 23 subjects,
without untoward affect, and have since been identified an diaaepee-like.
undergoing clinical trials as oedetiva—anxiolytica.

I trust these data are useful.
Sincerely yours.
Fink, 3.9.
Praia-cor of Paychiatry

Mex

MF:ig

�</text>
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                  <elementText elementTextId="105540">
                    <text>wry—acr—
q
w.».=.~wmmv../mnw.,-- x I-K'»'
.

m

g:

'4

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1—9“7" .s'up». an“

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I

.
.
‘k-rwci.-1vr‘n.,-r&gt;".Pr"/W3‘rm
w
.

.

.

.

mummy-w mun-w, ‘w-wwr‘ ..‘ ‘~7’.«'-:~C_p-:qv~-ar«‘.(-3A"1IV'RMIVZ

"-ww:-r—;~v\'v-Y"ﬁYYn-“ww'ix‘

‘4,"

v

(m.

l,

October 10, 1967

.

-

V

.

~7‘
3r. R. Kaelbling
Associate Professor of Psychiatry
The Ohio State University
Department_of Psychiatry
.

7....

W.

V

430 west

“maven-v

.V

loth

Avenue
Columbus, Ohio 43210_

_

.

‘

{

~

‘Dear Dr. Kaelbling:

“VHF...“

has been some months-since we discussed Unilateral ECT
and-during the interim my associates‘and I have reviewed the
literature and decided to undertake a systematic study. Recognizing
that the populations available fer convulsive therapy studies in a
municipal hoSpital are limited; we have been most fortunate in
establishing a geod relationship with the staff at Gracie Square
HoSpitala This hospital is-a erivate facility with a very active
in—patient and euteoetient treatment program. Dr. Lothar Kalinowsky
has agreed to help_us in selecting cases both from his own popula~

It

v

-

»

y-Wpy-v-l

'M'J-

Mums

tion and from those of others at this hospital.

«7

«

WWVV

rv.‘

course, we reviewed your work carefully and were impressed
with the data presented in your unilateral studies. Gur'present
protocol calls for a comparison of unilateral (non—dominant) seizures
with bilateral seizures given at a customary_rate of three times a

~4\

Of

r

.714‘

-~..-

r:
:u

week.

Hurry-«w:

The

criteria for

change

will

be memory

.

tasks, quantitative

measures and behavioral scaless- If indeed the unilateral
seizures show lesser degrees of memory impairment and equivalent
of
clinical results, then_we would nape to undertake a comparison
and
the MMECT as described.by slachly, both in the unilateral

a“

EEG

-»~r

bilateral

modes.

"

'

‘

-.

Will be extending.both your work and that
of Paul Blachly.’ For this reason, and with the collaboration
sof'Dr. Kalinowsky, I would like to ask your permission to list
you as a consultant to this project. We have asked Dr. Blachly
and-he had'agreed to assist us. As you can guess, such a study
will be difficult to carry out with proper controls and we would
he encouraged if you would be able to assist us from your experiences
This will also give.us an epportonity to get to know more of your

,In this study

'

'

‘

we

experiences.

’

‘

say I_have your permission to
"'
this project?
'

My

1

.

best regards.

list you as's

consultant to

.

.Sincerely yours,
Fink, M.D.
Prefessor of PSychiatry
“

Max
L

MFrkp&gt;

.

“q..-

,

nrJ-~9~vvvwv

~-'-'-P"|--'

�</text>
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                    <text>July 10,

19 70

Dr. Fred Kazan
Upjohn Company
Kalamazoo, Michigan
.

.

Dear Dr. Kaban,

?
:-

h

.

--

Wm-r-mwv'u

rwv-wwwr

:mvw

ZW'u‘VCInv

‘
‘

”adv—”WW3!!!

I have checked with the New York representatives of
Honeywell, regarding the Honeywell 8100 tape recorder. They report

that the instrument was Specially designed, and does not follow IRIS
standards for head configuration, and would therefore not yield tapes
compatible with our reading system.

They indicated that Honeywell did make a Special head
which could be used to modify the instrument but this would be

expensive-~ almost as expensive as buying a new instrument. They
suggested you contact their Detroit office for further data.

“.mp1

7
w,

..

We are planning to purchase a 1/4 inch A—channel IRIC
compatible instrument for another project and would suggest that this

instrument be duplicated in Upjohn laboratories
to send us tapes. (Hewlett Packard 3960A

laboratories.

Again,

my

4

if FM
it

channel

thanks for the opportunity to

seems useful

recorder, $4,285)

visit

Sincerely yours,
Max

Fink, M.D.

your

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                    <text>February 8, 1971
Dr. Fred lagan
Upjohn Company
Kalamazoo, Michigan
Dear Bred,
At the APPA meetings this weekend
speak to Ronald Fieve about rubidium.

I

had the opportunity to
has an IND but the
restrictions for human trial are severe. To date he has increased d
dosages gradually to a dose (he could not recall) which seemed
He

insufficient to alter mood or behavior. He does have extensive
laboratory data, primarily blood, urine and EEG measurements.
These have been summarized in a report to the Aachiveb 06 Genenaz
Rbychlattg, but the report has not yet been accepted for publication.
In addition, he has animal toxicology
studies in progress.
He knows

(3 generations of mice)

of Plotman's public statement but diacounts the

evidence as inadequate. One basis for his interest is a review
of 19th centurj literature in which he noted many claims of therapeutic

benefit.

I was impressed with his enthusiasm and interest. He has a
good reputation, and while the evidence for psychoactivity is slim,
I would like to hear him discuss his work in public. If your interest
is sustained, I am sure he would be pleased to discuss his data.

It is

an

interesting problem.
Sincerely yours.
Pink, M.D.
Professor of Psychiatry

Me:

MF:kt

�</text>
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  <item itemId="4782" public="1" featured="0">
    <fileContainer>
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                  <elementText elementTextId="106174">
                    <text>u,

M"

Wm

Hatch 29, 1971
Dr. Fred Regan
Manager, CNS Research
Upjohn Company
Kalamazoo, Michigan 49001
Dear Fred,

Since our last note, we have established a dosage for diazepam,
and begun our defined classification study of U 28,773. It should take
8 weeks for the data collection, and 2-3 for the analyses, so that I
anticipate our report by mideune.

L'ﬂm.

:.

Your notes on the duration of

action of U 23,773 are most
with
for
clear
so
duration
a
interesting,
effect, we may wish to
approach the clinical effects in a study of a different design.

A

with a flat extended duration of action would be most
powerful as an antianxiety agent. Our present problems with diaropam
and chlordiazepoxide are their relative short duration of action,
requiring repeated dosage, repeated risk of sedation, and the
development of tolerance, requiring more frequent administrations
in some patients. An effective, flat dosage regimen may avoid
some of these difficulties. Your note, that a halfwlife &gt; 24
hours would make you "bearish" is puzzling. Such a feature may
increase the risks of uncontrolled use, but may be more useful
in reducing the euphorigenic risks. The higher tithe, higher
euphorigenic action, and higher addiction liability of heroin
compared to methadone are documented. Both drugs effectively
compound

reduce opiate hunger, opiate withdrawal symptoms, and may usefully
substitute, one for the other. Yet, methadone is considered the
safer drug, with its longer duration of action. The extended duration

of action enables

some

useful applications.

Come visit New York soon. Meanwhile, even if the rubidium fever
has cooled, the enclosed announcement may be of interest to someone
on your staff.
try to be there and will send you a summary if
nouone else is able to go.

I'll

See you soon.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

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August 6. l968
Hrs. Carol Kehn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

Enclosed is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers. not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.

you a

now have more extensive follow-up data and
more rewarding than the initial evaluations.
We

it

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

is

even

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                    <text>August 6, l968
Mrs . Carol Kahn

Medical World News
299 Park Avenue
New York, New York
Dear Mrs. Kahn:

is the reprint you requested. I am also sending
preprint of the very high dose fluphenazine study. If
this interests you it may also interest your readers, not only
as a statement of treatment efficacy, but also as an example
of the impact of present governmental regulations on American drug
We found it difficult to undertake these trials here
research.
and elected to carry out the study in Istanbul.
Enclosed

you a

He now have more extensive follow-up data and
more rewarding than the initial evaluations.

it is

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

even

�</text>
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Dr. Robert L. Kahn, Ph.n.

Division of Psychiatry

Hantctiorl Haspital and Mbdteal Cantu:
111 East 210:h saxtct
low York,

wa

York

10667

Dear Bab:

tollawing all aha recnmnnndatians in our last discussion. I hive
accepted the full_rnsponsib111ty for this draft. Rscogniatuz tbs unotionnl ptoblcna involved, I hawc deleted Hal's nuns. In thin draft. I
have noounnd the senior authorship insofar as you seen to be raluctant
to do anything with the documnnc. It-yon uuuld like. I will haw. the
first pass radon. and haw. this suhuictud to tha Archivbs of coastal
Psychiatry. with you Ii tunic: author.

I! I

do not; hear from..§ou.
and
is
tubal: an
faeeary.
ﬂy

it

it

I will name that: this {draft is satisto Dr. Grinkar.

but “and: .
Sincerely yours,
ﬂax rink, K.D.

H131:

Professor of Psychiatry
‘

�</text>
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1965

Robert L. Kain, Ph. I).

.

ﬁnd, Soctim of Psydxology
Divisionof
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Hontaﬁm Hospital and Phdical Carter
111 East 210th 8mm:
Bram,

New

York

10%?

M3023:

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wheatmm.

Sinmly yours,
Fink, Md).
meeasw of Psychiatry
Max

mzjm

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an.

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Farm

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audio-Ll Comer

111 East 210th Stunt
Haw York 10%?

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Dear Bob and Nat:

our manuscript. Congratulations!
War has
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Manor of Psychiatry

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Professor of

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1965

Dr. Robert L. Kuhn

of
W1:
Itafiom lbspital
Hill
may.
m.
Bar

Psychiatry

‘

3

New

93:

York

Roads

Bob:

I an

no planned with

the

malts of tha Tridbspim

«mmmwmmofmmmm.
Imiladoutthisoldmwtmdlnwhaditmotypod.

paper, md

that

Would

ymmnditvithwlBBSmnaMmifitismmh
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Idomthmifthinlatmrwillmhwuinmmrk
Wilcoxfm'dmvieitinguithywtrnmxtthnlmVe

orincmoam. IWyouwmahappymmmwpositim

mmumcmp.
My

but mm.

Sincerely yours.

Mijm

PM, NJ).
m
meeaaor of Psychiatry

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Robert L. Kahn, Ph.D.
Head, Section of Psychology

Division of Psychiatry
Mtofiom Hoopital and Medical Center
111 East 210th Street
Bronx,

New

York 10467

Dear Bob:
Thank you for your oonments on the EEG paper. I have
included them in the next draft and have sent them on to
Martin. So for, I have received no galley proofs or other

communications from Dr.

War.

I hear otherwise frat: you, I will propose sending
Campuhemive PA ychéax/Lq, and Conﬁim'a
Nematogica, in that order.
Unless

this to the

JNMD,

to you, two changos have oooumd in my
brother has aooopted an appointment at the Hines

Since talking

family.

My

VA and the Stritch Medical School.
11153 mans that I will
have a reason to come to Chicago 8am time this wintor and
hope that we may get together than. Would you send me your
new home address when you have a chance?
My

host regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry
Max

m‘mp

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                    <text>Jam 19, 1966
DP. fbbox't L. Kuhn
,1:

of Psychiatry

Univmity of Chicago

Wan, Illimis
Dear Bob:

article ”Sociopaycmlogieal Aspects of Psychiatric
mam" appoamd in the latest isms of the«1113Amhivas,
The

I am sending
We have received the mar sheets
send these on to
and
will
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supply.
you a

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you when
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I receive than.
have already waived a

and thus;

will be arm-mud.

m

a!

mint requests

I visited your fine city last meaday and put in a call
to you. I had the mama to visit the Illinois State
Psychiatric Institute. It is a fine research and training
concur. I was very nmh harassed with the facilities. and
imludingtm
withtlosembcmofthastaffwrmlm,
clinical director who spoke highly of his eontacts with you.

I hope to have the appormhity to visit: Chicago soon.
and would like at that time to call you.
My

best regards.
Simemly yours,
Pink, 24.1).
Professor of Psychiatry

Max

H‘Ezjh

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                    <text>September 27, l967
Dr. Robert L. Kahn
Department of Psychiatry

University of Chicago

Illinois

Chicago,

Dear Bob,

After a hiatus of eight years, I would like to undertake another study
of convulsive therapy. The recent modification of multiple monitored ECT
and unilateral ECT have stimulated my interest. while we have only a few
cases in treatment at Metropolitan Hospital, I have been fortunate in
obtaining the support of Dr. Lothar Kalinowsky and the staff at Gratie Square
Hospital and would like to undertake this study at that institution.
writing to you today to obtain your permission to include you
among
list of consultants whose advice I may wish to call upon as
we become involved with the details of this project. As you may guess
I am applying for support from NIMH and would like to make this a
definitive study involving many of the suggestions which were made
during our active days at Hillside.
I am

the

May I

have your permission?

Incidentally,

and I did so with a

recently invited me to give a talk at Hillside
great deal of enthusiasm. I found the hospital unchanged.

Hal Esecover

Pollack and

Lurie were old faces in the audience. The
interested in the topic which was “Computers
in Psychiatry." I visited the laboratories and was surprised to find our
old tape recorders, the apparatus built by Eric Karp and many of the tapes
which you had made still on the shelves. The EEG laboratory now has a second
machine and they are particularly involved with a detail ofihe EEG known as
Mitten patterns. There is much talk of building a research building and I
was surprised to hear that our old plan had been puled out of the files and
an application resubmitted to NIH for support at the same level as we had
tried eight years ago.
Don

Klein.

Max

residents were bright

Abe

and most

I trust that Dan Freedman was kind enough to extend my regards. We
met some months ago in Washington and had a delightful discussion of your

programs.
My

best regards.
Sincerely yours,
Max

Fink,

H.DD

Professor of Psychiatry

Mszp

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                    <text>November 27, l967

Dr. Robert L. Kahn

Associate Professor
Department of Psychiatry
University of Chicago Hospitals and Clinics
950 East 59th Street
Chicago.

Dear Bob,

Illinois

60637

'

Perhaps the best way to describe the project at Gracie
Square Hospital is to review the enclosed application to eIHH
for support. I have always regreted that we did not complete
the study programs at the time that we were intimately involved.
In the ensuing decade. little additional information has been
published and I think that what we knew then is still much of
the information available today.
The

ECT

.

interest in multiple monitored

ECT and in unilateral
reevaluation
the
a
of
justifies
process. By utilizing the
I
me
available
to repeat and verify
hope
to
resources
today,
the observations we made then and add to them the rigor of more
should then
systematic collections. If the program succeeds,
be possible to write an important chapter in the history of
'

it

this treatment method.

I should like to be able to call on your experience since
think you can provide a critical judgment of the social and
—psychological aspects of these studies.

I

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:hp

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                    <text>July l8, l968
Dr. Robert L. Kahn

Associate Professor
Department of Psychiatry
University of Chicago Hospitals and Clinics
950 East 59th Street

Illinois

Chicago,

60637

Dear Bob.
The program of research in convulsive therapy is now
in Gracie Square Hospital. 1 have two resident
progress
physio ans working with me and a fine experimental psychologist.

in

I would like an opportunity to have you meet with my
staff and to discuss their programs. Do you expect to be
in New York within the next two months? If not, would you
like to come on a visit and we will defray the necessary

expenses.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>w: “w ...

»

"1»

an.”

«‘

mun,"

a

.__, -r»4(«

-—.-»

”Warwr FW—v‘u‘w’r‘u’ ”v“. w m

19 March 1974

Joseph Jaffe, M.D.
ﬂaw York Stat. Paychiattic
722 West 168th Btrcot
New

York,

Haw

Institute

York 10032

Dent Joe:

I nisand

convocatian.

you

in Boston at tho

APPA

and again cc the Bendor

Enclosed is a copy of my presentation to thc APPA. in which'
I havc taknn the liberty of quoting you dttnnsivqu. I hops that

the

later datt
‘My

havn not

vitiatod the conclusions of

1960.

bﬁlt regards.
Sinccrely yours.
Pink, M.D.
Professor of Psychiatry
Max

MF/cis
Baal.

�</text>
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                    <text>November 29, 1968

Dr. Thomas V. Ksicher, M.D.
Geigy Pharmaceuticals
Ardslcy, New York

last

Dr. Koichct,

I hsvs read the material submittcd regarding GP 41299 with
bclicvs that we can participate in a number of studies
interact,
consistont with your goals of establishing tho potsncy and clinical
safety of this compound as a hypnotic and/or a minor tranquillizcr.
As we review the available dots. the compound hss been touted primarily
as a hypnotic and no effort is described to ascertain its other possible
and

activities.
like to

Thres types of studies are suggested, and whilc one would

rcccumcnd each of then, neither time not
personnel would permit this to he demo.

1.

EEG

profils analysis:

The EEG

available stuff

profile of

GP

41299 can

in volunteer subjects, on single oral trials. and the
spectra can be compared to a standard sedative (snobsrbitsl or
diatopcm) and to other compounds as imipramino. fsnflursminc sod
chlorpromszﬁnc. to ascertain its clinical similarity to thesc agents
at the dosages tested.

be soscsscd

2. Comparison with chlordistopoxido in the therapy of
clinical anxiety: The use of ODE as a standard in s mantcl health
clinic population has become accepted, and as hsvs undertaken studios
of other minor tranquillizsrs in comparison with this compound. A
similar study of GP 41299 should be considorsd.
3. Soporific activity in opiate withdrawal: Patients
withdrawn from opiates with methadone complain of severe insomnia.
The standard procedure is to ndoinistsr oothyprylou (Rolodex) and
this is generally acceptable. we would suggest the direct comoariscn
of mothyptylon and GP 41299 in a random sequoncs, for 3~S nights.
Acceptance by this population would icdiccts s high dcgrcc of soporific

activity.

would be pleased to undertskc any of those studies, with
study as the most profitable for you «w the study that may
add materially to your analysis of this novel compound. May I suggest
that you call my office and visit with on on December 10-12, December 16
or December 23. Unfortunstcly, I will be out of my office at the other
timss in the next tow weeks.

the

We

EEG

�u
"Jaw-'34”

Vrvw'

"r

m‘-g—-,-‘-.

«wmwamxmw—v-

Kaichar, Gutsy

'7

Thank you

..-

w

,-.

information.

November 29, 1968

for the opportunity of tevicwing this interesting

N—'r"mp~a-'..d

Sincarely yours,

“ﬂit-3’1

www—w-

s
""25:

r."

ea)"

Fink, M.D.
Frofeusor af Psyehiatty

Max

v
v.»

-

mil

In ch¢ sweat that an EEG study is of intﬂtiﬂt, I would also
recannnnd that parallal atudiau be undertaken ta determine the
affects of GP 41299 on the 'alaap«print' -« the eomputer analysis
of the allwnight sleep E36. Tia techniquas available in this
country provide more quantitative information than reflected in the
summary from Dr. Carma, ané allow a more definitiva claauificgcion
of I ate compound and its coapnrison with established alaepvproducing
agonca in quantitativn terms.
P.8.

-

v

up"

m"

"w

~

w-

~—

r;

rrw—Ivz-wm'r-w—v

«

V...

F";

«-

SW'WFMF"

J

.sv—n

Km”

mnwrmﬂwrmwawwv

vwmqmvmnwﬂl"

"Ha

�</text>
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                    <text>a... 13“.

“M w... ‘EVIIM-

.

nun «»

m

)vv-MVI‘H'VM»

.

ww.wi_w/w. ., p;;,~'~1—$b‘—vaw~_."im snug—Wm..-

"a

own—Wu

.Vn‘ny—vvm4

vim-V:«Maw-w t

rr'

wz—vw—wuarw

-

'-9-ﬂ- u

-.

mew w.” 4-" v-n-

January 24, 1972
Samuel Kaim, M.D.
1200 N. Vash Street

Arlington,

Va.

22209

Dear Sam,

It was a pleasure to discuss the programs of the V.A.
with you in Las Vegas; and I do look forward to joining you in the
sessions in St. Louis.
There

is

a need

for the

NIMH

and/or the

V.A.

to undertake

a more extensive evaluation of l-alpha—acetylmethadol. I believe the
V.A. can do it, and am taking the opportunity to enclose a copy of our
report, comparing methadone and l-alpha—acetylmethadol. The report has
been accepted by the JANA, and should appear within the next 6 weeks.
have continued our studies since the report was completed,
and the present group of patients continue to fulfill the expectations
established by the patients in the study. I would like to establish such
a study as part of the programs at Stony Brook.
We

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>v a-v- W‘s WWMW‘WAuaecnwnﬁgn

w

,

WM'e‘w-"~mm~:y&lt;s‘-«m:-rmm~ «y;

"w

»v:

“."w..m7WW\YI«*—w

'«VTF'V&gt;.IK

‘7’”.

'1 --

dumq

'11'

m

.-

,

“mu-w»

w

-'-"

er

A

-.
v

soytamber 28. 1972
Samuel

mm.

14.13”

Director; Alcohol and Drug
Dapondnnce

Service,

Veterans Administration,

thhtnaton D.C.,

20h20.

Dust 8am,

I

am

pleased ta enclose a draft of our report:

Levomathndylz

?rolongod Duration 0f Opioid Effects,

Including Cross Tolorunca to Heroin. 1n

Nun;

As we had pramised, VD completed this study during
nunmnr and damonntratod that the minimum effective
dose for clinical
in 70 mg. lavomnthadyl three time:

the

trial

i amok. I believe it would ha usefu1 for the Veterans
Administration - Collaborative Etudy to assess either this

slightly highcr.
W3 are submitting this report to the A.P.A. for
their considerttian far the 1973 wasting.
done or even

my

best regards,
Sincerely yours,

Mt: Fink, M.D.
MF/iﬁ
Ema.

w

’

1‘4

‘5
‘71:,

'
~

~u.:wxW-JF

My

�</text>
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                    <text>Samuel Kain, M.D.

Coordinator,

VA—SAODAP

Veterans Administration
Washington, D.C. 20420

September 15, 1972

Steering Committee

Dear Sam,

‘I have read the protocol of the levomethadyl vs. methadone
cooperative study. The design is satisfactory, and the forms servicable.
Some

suggestions:

Side effects check-list: What is # 12 ?
Attachment C: Who fills this out, and is it to be verified
Attachment D: Is this to be verified ? By whom ?

?

References: For f 8, see attached. You may also wish to
summary of the study of the duration of methadone's cross tolerance
may be relevant to the issues of the study (Reprint enclosed).

include a

for

it

We are completing the study of increasing dosages of
levomethedyl, and the data at present indicate that 50 mg LAAM provides
blockade to 25 mg heroin for 1! hours. but at this dose of LAAM, there
are subjective complaints of discomfort. To suppress discomfort and to

maintain pupillary miosis for
The
My

72

hours,

report will he sent to
best regards.

80 mg

LAAM

is required.

you as soon as

it is

completed.

Sincerely yours,
Max

Fink, ..D.

Professor of Psychiatry

�</text>
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                    <text>TSSB-éhl

April 25. 1973
Dr. Herbert G. Quushan. Jr..
Degsrtunnt of Haurology.
Albcrt Einstein Gallant at Mbdtcinc,
1825 Eustchastor Bond,

Bronx. a.Y.

Inn: Doctor Viuahan.
announeeunnt in Biamadioal Nave of rdbrusry. 1973
reported that ”Shock £harnpy aan produce tons cellular
disruption-tullawing largc uuuhcrs of sneaks. according to
Dr. ﬁafbert G. Vaughun, Jr.. associate prafesaor or
nourology at Einltcin Modictl Eahool. Bronx. N.Y. Same
eonsider 100 a large number. ethars stop at 12”. I an
editing tbs pwouaeding: at a eenfaraane on the Paychdbiology
a! 30?. nnﬂ.vnu1d like to auannnt tbs reports with any
dﬁxn 13 this rosnrd. I am writing to tax far the citation
uyon which the quatatioa is btsod; or. if it 1: unpublished.
I vauld,)9 grateful for a summary 9r description of the
proaeat Iueh as any be available.
An

Thsnk you

for your autistcnna.
aincarely yours,

Mb: Fink. 3.9.
Professor of Puychintry

HF/ij

�</text>
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                    <text>March 11, 195“

m1 in Psydﬁatry
Chief. Researchm
and Mammy
Veterzms Wmﬁm
Deparmnt of radians
m5

C.

.

and Surgery
Washington 25, D. C.

mm:

Thank you

for your invimim to attend the Ninth Amual

V.A.

Cmfmneeinxmﬂty. Iramnotmnwell, mainland:
smtratlwillbamadytoattandmtinwbytmendofme

nth. IfIamflyin,Iwilldoso.

Mover, I would like to cxtend your invitatim to

one of w
waodates, Dr. Ivm Slam. Dr. Solemn has men a. staff
of this Institute since Jammy, 1963, and has mam
annual-x1: job in a 11qu of payehoplmmoolomeal studio‘s.
May I W him in W W? Best wishes for another mam}.

Mr

mating-

HP/jb

Simemly

mu.

Pink,
m
Erector

No Do

�</text>
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                    <text>,

WWW”.

.-_‘-.,.___v.-.

.mm

.mm,..,-_,..

.,.,,,_WI

,.

February 22, 1972
Samuel C. Kain, M.D.

Director, Alcohol

&amp;

Drug Dependence Service

Veterans Administration
Washington, D.C. 20420
Dear Sam,

.m

pawl-"Wu”...‘mu,’

I look forward to participating in the 17th annual V.A.
Conference in St. Louis next month. At the and of the week, I will have the
time to write a summary of my presentation on tho panel, and should send
it to you next nook, well in time for the session.
A.nhort c.v. is enclosed.
For the teaching session, I will prepare a summary of our
present treatmont approaches, onphacizing the similarities and the
differenceosin using mnthadono and lnvoncthadyl, and cyclazocino and n31—
crane; and the relation of thosn drug rcgimona to rohabilitation, caaawork,
re»education, counselling, and psychopherapy.

It was kind of you to consider my serving on the steering
committee for the collnborative studios in drug abuse, particularly for
acetylmcthadol. I would be pleased to contribute whatever I can. and have
that my experience may be of assistance. (My paper on l~alpha~acotylmethado1
will appear soon in the J.A.M.A.~— they changed the name of the drug to
the

new

generic

'official' titlo of

My

LEVUNETHADIL.)

best regards.
Sincerely yours,
Max

Fink, 3.9.

Professor of Psychiatry

�</text>
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                    <text>April 6, 1972

Dr. Samuel C. Kain

Director. Alcohol

and Drug
Dependenco Service

Veterans Administration
Departmcn: of ﬁedicino and Surgcry

“tubington, 9.6. 20b20
Dear Sam:

Enclosed is a copy of our original levomethadyl protocol
(dated 1/19770) and a suggested one for 1972«73, dated 3/31/72.
In the latter, I have tried to indicate a possible program of in—
terest to the V.A.
'

-

Please feel free to adapt, modify, or use this as you
find useful.
I look forward to seeing yen on April 28.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

3F:13
Enc.

may

�</text>
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                    <text>Q

ﬂavonbor 15. 1972

Samuel. c. Kain, em).
Coordinator, VA—SAODAP
Steering Connittoc
Veterans Adniuiatrution
Bepartmont of ﬁndicios Ind Surgery

Hashington, 9.0.

ZQéZO

Dear Sam:
The preposal for a cooperative study evaluating the usa of
narcotic antagonists in withdrawal of addicts from nothadona maintenance is interesting. I have a tow questiona which may olucidatc

the proposal.

1. The record does not indicate the basic for the choice
of domepin as an antidepressant, rather than imipracinc.
2.

Why

are sufficient?

elect s

21 day

induction to cyclasocino

whoa 4 days

3. Why scloct 6 mg/day no the done of cyclazocino, if antidepressant activity is to be tested, whom the antidepressant activity
of cyclazocino has baen demonstrated at 1 1/2 to 2 1/2 mg/day in
dopressiv: patienta? Or, is part of the tout a comparison of nor—
cotic antagonist activity of cyclarocino with doxopin‘s antianxiety

activity?

Jeff: and Sonny (pages 3~A) suggests they
and phanothicxines in small doses,
antidopressanto
tricyclic
useful. By what criteria? The can: quostioua are raised for the
data of Kline and Pfizer (page 5).
found

A.

Raferoncs to

5. 1a a ton sock withdrawal from mothadona fcoaiblo? Would
such a slow withdrawal allow a high rate of racidivism? Perhaps, a
more rapid detoxification, at 5 og/day for 10~20 days would be foa-

.ibha

�J”

-\-‘:‘
,

Hovombor 16. 1972

Sonuol C. Kola, M.D.

Barman

6.

For adverse

rotations, the protocol auggasto roaching
is unoful only during busi-

or myself.
I ouggoot 516-‘i4-2413 or

noos hours:

The Stony Brook phone

516-466-5444 evenings and vookondo.
Hy

2&amp;6?

during businooo; and

boot Vishnu.

Sincoroly yours,
ﬂax Fink, H.D.

Professor of Poychiatry

ﬁing

�</text>
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                    <text>January 7, l969
Dr. Thomas V. Kalcher
Gelgy Pharmaceullcals
Ardsley, New York l0502
Dear Dr. Kalcher:
GP

Enclosed Is a deflnlflve profocol for The sfudy ofTo
fhe
4l299. We would propose a slep—wlse approxlmaflon

cllnlcal evaluaflon
lf fhe

flle

program

of

lhls

for

The

compound.

lnltlal

EEG

lrlals are sallsfaclory.

lhe prolocol wlfh our Commlffees.

we

wlll

To

flle the necessary

In such slralghf—

forward sludles, approval ls generally avallable wllhln 4 weeks.
Thls wlll provlde an opportunlfy for us #0 select subjecls and
forms

for lhe

FDA.

capsules
If +hls prolocel ls accepfable, we wlll requlre 50lnacflve
of
an
25
capsules
of 25 «9 GP 4l299 and, If posslble,
dexfrose.
lacfose
or
as
placebo,
Thank you for lha opporfunlfy of preparlng lhls profmcol.
Slncerely yours,
Flnk, M.D.
Professor of Psychlalry
Max

Mszp

�</text>
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                    <text>March

5,

1970

ﬁr. Anthony Kales
Department of Psychiatry
University of California Medical Center
Los Angeles.

California

90024

Bear Tony.
1 have just returned from California and in checking my
notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.

I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is.
of course, preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in new Yorkk

Sincerely yours,
Fink, M.D.
Professor of Fsychiatry

Max

MF:kp

�</text>
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                    <text>March

5,

1970

Dr. Anthony Kales

Department of Psychiatry

University of California Medical Center

Los Angeles,

California

90024

Dear Tony,
I

have

just returned

from

California

and in checking

my

notes find that I had promised to send you the enclosed information
with regard to our experience with doxepin.
I am also enclosing a sample protocol and interim report
of a compound which is now undergoing study. This information is,
of course. preliminary and I trust will be verified in the ongoing
study.
Come

visit

us when you are in

New

Yorki

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 26, 1967
Dr. bother Kalinowslw
115 East 82nd Street
New York, New York 10028

Dear Lothar,
'Iharﬂc you

very

much

for a most pleasant lunch.

Iamnotsurprimdthatthisoldmportonhdoklmis

notwelllmovm,mt1amtakingthe1ibertyofsendhgyoua

reprint.
May

5.

I look forward to visiting

you

at Gracie

Square on

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>M‘qpﬂii'

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July l8, 1968
Dr. Lothar B. Kalinowsky
ll5 East 82nd Street
New York, New York l0028
Dear Lothar,

Please accept this copy of "Anticholinergic Drugs."
This symposium was presented in Washington in l966 and
it represents a useful portrayal of our available knowledge.
from

The
NIMH

convulsive therapy project has received support
and I look forward to our continued collaboration.

Thank you

for your assistance.

My

best regards.

Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp
ENC .

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November 12, 1970

Yi‘v'mruwr',

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Dr. Lothar Kalinowsky
115 East 82nd Street
New York, New York

wraneruw—

Dear Lothar:

Vw-_—ﬂ\'~"l‘~!"’

“£1.11

WWI-ayw-W

,mr

mtg-V

-

For two years we have been guests at Gracie Square Hospital,
and with your cooperation, have accomplished the mission originally
set - to compare unilateral and bilateral ECT. Our studies have
been gratefying. Four reports are completed, and two are in press.

am enclosing a preprint of the summary report as submitted to
the Archives, in part to thank you for your cooperation and indulgence.
Without the help and tolerance of the staff we would not have been
able to succeed.

I

Because the next phases of the study require special control
we are moving the study to Metropolitan and Kirby

of the cases,

(Manhattan State) Hospitals.

Again, my associates, Drs. Abrams, Dornbush, Feldstein, Roubicek
and Volavka, and our assistants, express our gratitude for your assistance.

Sincerely yours,

vies-wr-

an

Max

Fink, M.D.

Professor of Psychiatry

Hszt

we

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P.S. You know how we valued your support and cooperation, for
without them, the study could not have succeeded. Many thanks.

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�</text>
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                    <text>November 23, 1971

Lothsr B. Kalinowsky, ﬁ.D.
115 East 82nd Street
York, ﬂew York 10028

New

Dear bother:
Your comments about the

Q

s

A

were most cogent.

We very much
regret 'mieleading' you. In our first discussion, I had hoped to be able to quote the answers from each re~
spondent without any summary. out so many responses were of the ’yee'
and 'uo' variety, which seemed unreadable unless we provided text and
substance. This, Dick and I did. Perhaps, it is unfortunate that we
tended to quote the more complete responses, even when we disagreed
with them. Your comments led us to edit the answers, and I am enclosing
a revised text.

Should this text meet with your approval, we can make these
corrections in the gslleys. Should this correction not meet with your
approval, perhaps you would make other corrections, and we could edit
the galleys.

If there is another

course that

will serve your interests

and those of our readers, we should be pleased to hear from you. I
expect to use you in Mexico City, where we may be able to have an op-

portunity to resolve this question at leisure.

Again, we are grateful for your candor and c00perstion.

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

Hfzig
Enc.

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                    <text>"WWW!“

~— -—.

m. wr‘m.‘ :mvﬂmwv—w-w ,»m~—wr—mwm.—~—va~———m-~~—
~—

-‘4-

November

8, l97l

Dr. Lothar Kaiinowsky

ll5 East

New

82

Street

York City

Dear Lothar,
i am
enclosing a draft of the Q &amp; A contribution to
the Special issue of seminars in Pbychiatry. Following your suggestion,
the contributions are summarized, and i am enclosing a copy for your
information. Any suggestions for changes will be appreciated.

that

it

issue will appear in February, and i am hopeful
will complement your text, which is the standard.
The
My

thanks for your cooperation.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

———_ -«

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                    <text>December 2, 1975

Lcthar Kalinowsky,

115 E. 82nd Street
New York City

M.D.

Dear Lothar,

I read, with much interest, your note about the Congress of
Psychiatric Surgery, as published in Psychiatric was, and wondered about
the lack of interest that you cite. I wonder if the political factor you
cite is indeed as strong as suggested. I would look to ourselves, for I
find that our peers, particularly those in the Society of Biological
Psychiatry, are as smug and as disinterested in clinical issues as the
rest or the APA.V Another factor may be the lack of publicity for the
Congress, for I cannot recall seeing an invitation.
One response that may be helpful is for the secretary for the

next Congress to send announcements to the mailing lists of the former
Electroshock Research Association, EPRA, the Society of Biological
Psychiatry, and the American Psychopathological Association.

Another response, if you believe that the Society of Biological
Psychiatry, in swallowing the Electroshock, cog, and Insulin groups, should
be interested, is to act to lead that organisition along clinical lines.
I have been dissatisfied with the programs of SBP, and I discussed this
with Charles Shagass a few years ago when he was on his way up in the
Society. He seemed to listen, (with one ear) in appointing various comp
mittees last year. we did have a clinical group for the Program Committee
this last year. He also appointed a Nominating Committee of Leo Alexander,
A. Friedhoff, and T. Itil. These men, however, under the leadership of
Leo Alexander, elected chemists to the leadership
and with the aged
hands of Wortis, Himwich, Bennett, and Thompson still very much active,
there iaslittle hope for a change in the next row years. Perhaps, in your
position as a statesman of the Iociety, with Heath, Alexander, Nurnberger
as friends, you could still see that young men, with clinical interest,
are appointed to leadershipfroles, especially the Journal and the Program
Committee. Then the society could play a clinical role, as it promised to
——

play when it absorbed the clinical societies, and psychosurgery could get
a reasonable hearing.

�Lather Kalinmky,

M.D.

12/2/75

~2~

could consider the development of another notional organ~
isotion on the somatic therapies elons the lines suggested by Len Commer.
(One

This is a formidable task, and one that would be conflicted at the outset
because of the different constituencies ~~ the academicians. clinicians,
and

the hospital therapist with

little academic interest.)

Another suggestion: would you orier a panel on peyohoourgery
program? It may not be too late.

for the next meeting's

Perhaps some of these actions would serve to alert members or
our organization: to the next meeting of the Congress of Peychiotric
Surgery. At the least, perhaps this note will remind you to add my name
to the mailing list.
My

regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mex

MF/mr

P.8.

~

Your

it,
and Turkey.

on

letter

but perhaps

on

we

-

I've never been
the Orient Exprees was stimulating
could try e section in one of our trips to Greece

�</text>
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                    <text>August h, 1978

Lother Kelinovsky,
30 East 76 Street
New York City

M.D.

Dear Lather,
“It,

,,....~,..,_

I have Just returned

the opportunity
reprints regarding our studies of the narcotic untesonists in opiate dependence. I trust these are helpful.

to enclose

some

from Europe and take

A.

Since coming to Stony Brook, I have not carried out

studies of the antagonists. It was one of the surprises
of my move that ve were unable to find a patient population with
opiate dependence in Suffolk County.
any systematic

My

regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry
Max

1.

"Wm

W”

/

�</text>
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                    <text>1v

V$dﬂme

—

a...

November 7, 1978

Lothar Kalinowsky, M.D.
30 East 76 Street

New

York City 10021

Dear Lothar,

It was a pleasure working with you once again in explaining
the progress in convulsive therapy. I was pleased by the presentations
and by the audience response, but was disappointed that the time was
so limited. Nevertheless, I believe the message was clear, and the
discussion indicated that the process of exploration by the Task Force and
the interaction with the community was successful. Thank you for your
contribution.

I also want to take this opportunity to thank you for the
splendid copy of your first edition. It is a welcome addition to my
library of works on convulsive therapy, and I will treasure it.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March

‘13,

1989

Lothar Kalinowsky, M.D.
Klinik Dr. Dohrn

Driesenstr.

10

8182 Bad Wiessee am Tegernsee
West Germany
Dear Lothar and Hilda,

1

Thank you for your kind note about the early days at the Psychiatric
I do not know as yet how i will use it, but something will come up.

Institute.

L “M”
i

a

1

i
i.

i

i

1

The APPA held a fine meeting earlier this month, with much emphasis on
the anatomy of the "brain as the basis for mental disorders. Some of the speakers
jumped from animals to man in a truly fantastic fashion. I am still not comfortable
*wffﬁatﬁe st'Fon'g em pha51son neurosdence which now dominates psychiatry
(especially in my department); it reminds me of the excesses of the psychoanalytic
teaching which dominated my training and my years at Hillside Hospital. Too much
of a good thing is still likely to unsettle one' s stomach.

Tony O'Connell invited the associate editors of COMPREHENSIVE
PSYCHIATRY to lunch and the discussion was interesting. The APPA is committed
to publishing the papers of the annual meetings in separate volumes. These have
poor sales, are not indexed in the national indices, and the published articles tend
to get lost. We discussed the possibility of issuing a supplement to the journal for
the articles, as well as asking the membership to subscribe to the journal as part of
their annual dues. Both ideas were rejected by the officers -~ largely, I believe,
because they want to have a 'book' edited by them. Also the APPA officers do not
know Tony and probably would want to name one of their own to be editor. So, as
each perceived the suggestions as threats, they were scuttled at its inception.
The first issue of- CONVULSIVE THERAPY for 1989 was edited by Richard
Abrams and is dedicated to "ECT in the High-~Risk Patient". is a special, larger
issue which is very well done and it should be very helpful for teaching in the next
few years. As] do not know whether your copy will be sent to you, I am enclosing
one for your use.

It

My

best regards and wishes for continued improvement.
Sincerely you rs,

Max Fink, M.D.

Professor of Psychiatry

�V'-

v

“w‘mﬂw~

‘

-

--

v

wimww ~MYwW—vuy

.77

‘VVWV. w... r~._—..—. "WW—”w

wruva—‘mw—wv._._.._r

7—- ,,

January 31, 1989
Lothar Kalinowsky, M.D.
Klinik Dr. Dohrn

Bad Wiessee am Tegernsee

West Germany

Dear Lothar and Hilda,
Thank you for your very nice card, and the news that the Klinik is a fine
one. am delighted.
I

&lt;

The next issue of CONVULSIVE THERAPY is now complete; it is dedicated
to papers and reviews of the medical aspects of ECT. Dick Abrams has put it
M-together, and is the issue editor. it will be put out as a regular issue-oi the journal,
but also reprinted, supported by Dick's company, and distributed at the APA
meeting in San Francisco. There will also be another special issue devoted to the
mode of action of ECT, and this one is being put tOgether by Harold Sackeim for

later this year.

The American Medical Association has formally endorsed the use of ECT.
print the resolution but it already has been discussed in the APA News. it is
of the progress of ECT.
sign
a good
We will

'

Harold Sackeim told me that the Psychiatric institute is planning a special
meeting in September honoring the 50th anniversary of the first use of ECT at the
institute. It would be a timely topic to cover in our News at Notes section. What
was it like in the early days at the Institute? In the early days in New York? I have
the notes from the Abrams interview with you. Could you supplement these? Is
there anyone else that I could interview to report the events of that period? 1
swoutd‘be =gald‘td put something together for your approval. Think on it; any notes
or recollections would be most helpful.

That is all for now.

My

best regards and wishes for continued improvement.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

.

_

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QT’L

I

Decanter 23, 1963

lather

B. Kalinmsky,
But 82nd Street
New York 28, New York

D.

M.

115

Dear

lather:

It sea

a pleasure talking to you in New York. I wm very
pleased that yaw camittee had extended an invitatim to Dr. Roth
to con-e to the United States. Dr. Roth has written ta Dr. Ulott and
as you kxww, wa wwld be pleased to have him visit St. Louis.
Dr. Ulett ia writing Dr. Ruth directly, suggesting that he
atop over in St. Louis during hm travel. We will be able to pmvida
him with an hmomxium which will adaqmtaly repay him far his mudtripuansportatim and othcr expenses bets-am New Yank and St. Louis.

mum for yam mmdatim of Other scien-v
mmmtmmitadmm tmgkxyoxmpmmm
we believe that such visits to our institution mid be most helpful
I should be

tists whomybo
in

mm

midway twining prom.
Mywvybnstwishw forﬂnNawYm.
Simmly yam,
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Dimctor

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BC:

George A.

‘

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2mm,0" new
ﬂ’mv'mwx’wnwur

—“"'5‘"

mmmm‘"

September 28, 1967

,

Dr. Lothar 3. Kalinowsxy
115

New

East 82nd’5traat

York, New

ank

10028

Delr Lothar,
Enclosed is a copy cf the appIication for support of the
study of ECT at Gracie Square Hospital. I want to thank you
again for your help and 100k forward to undertaking this study.
My

best regards.
Sincereiy yours,
Fink. M.D.
Professor of Psychiatry

Max

MRkp

enc .

A

&lt;

�</text>
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                    <text>September 16, 1967
Dr. Lothar B. Kaiinowsky
115 East 82nd Street
ﬂew York. New York
Dear Lothar,

Enciosed is a

draft of the grant application.

I yould

and make any corrections or
if
suggestions. I wili caii your office on Tuesday or Wednesday
to make an appointment to meet with you.
be

grateful
My

you would read

it

best regards.
Max

Fink,

M.D.

Professor of Psychiatry

Mﬁckp

�</text>
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                    <text>"WWW

April 13, 195»
Mr. Merton Kaliahman
73l+9a Tulam

University City 30. Missscnri
Dear Mr. Kaliahmam

mfemnca to your inquiry mganding a. stunner
fellowship .. we mgmt that no fumb are available

With

for this purpose.
We

wish to thank yen for" your“

Inﬁtituteo

intmst in

the

Sincerely yours ,
Phx Fink ’

Director

FEij

:{Q B.

�</text>
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                    <text>November 20, 1986
John Kane, M.D.

Director of Research
Hillside Hospital

P.0.

Box 38

Glen Oaks, New York 11004
Dear John,
Enclosed are the two reports of our studies of clozapine, both published in
1979. I was not satisfied that we had done an adequate analysis of clozapine's EEG
profile. I considered it an important study; first, because the compound was being
reported as successful as an antipsychotic, and secondly, because if its
antipsychotic activity is proven, and its EEG profile is outside that of established
antipsychotic substances, it would deserve a place as a unique prototypic substance
in EEG classification schemata, the head of a new class. Gil Honigfeld was unable
to accommodate my furtha' studies, but they should still be done.
I also enclose a copy of Morihisa's review of the EEG data in schizophrenic
patients. The review ignores most of the earlier BEG material, but it reﬂects the
more recent studies well.
My

regards.
Sincerely yours,
Max Fink, MJ).
Professor of Psychiatry

�</text>
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                    <text>Ii

_......_.,..,,,_.A_

June 2“, 1988

,_..V

.

w...

John M. Kane, MD.
Department of Psychiatry
Long Island Jewish Medical Center
75-59 263 Street
Glen Oaks, New York llOOQ

is...

V
V,

.,,

1
T
m

V'mﬁ'm—VV'WM-rwr‘

Dear John,
w:

Congratulations on your appointment as Chairman of Psychiatry at LIJH. It
is a particular pleasure to know that the hospital has sought a researcher as its

leader, and to join with other graduates of Hillside‘s training programs in wishing
you a fruitful tenure of leadership.

,

It was 30 years ago that Israel Strauss, Joseph S. A. Miller, and the Medical
Board of Hillside Hospital endorsed their research aims by creating a full time
position of Research Director. When Don Klein and my co-workers in the
Department of Experimental Psychiatry (that was the fashionable term in those
days, much like Division of Neuroscience would be today) wrote a review of our
activities for the Journal 9__f the Hillside Hospital in l96l, we not only looked back
at our accomplishments, but sought to direct the Board's eyes forward by calling
for a 200 bed clinical research center. We saw something specialin Hillside.
Perhaps it was ambitious, but we were encouraged by the dramatic gains of the
psychopharmacologic drug revolution, the nation was in an expansive mood (preViet-Nam, pre-Kennedy/Johnson),and we thought the cure of mental illness was in
our grasp.
In the interim decades, the leadership of the hospital seemed too concerned
with fiscal and operational matters to fully utilize its outstanding research
opportunities. Your success in building on Don's programs has given you the unique
opportunity to realize even more of the potential in Hillside's patients, staff, and
history. it is a fine opportunity, and the staff at Long Island Jewish Hospital and
the community it serves are to be congratulated in their selection.

My congatulations on your appointment; and my best regards.

Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>August 28, 1991

John Kane, MD.
Department of Psychiatry
LIJ-Hillside Medical Center

PO. Box 38

Glen Oaks, NY 11004

Dear John,
I received your memorandum of August 13 noting the By-Laws
requirement that members of the medical staff are to attend at least 50% of the
department/divisional conferences or meetings during the year. This note is to
request an exception, as I am actively involved in the campus at Stony Brook and
get to Hillside on occasion.

If you think it important, I will meet the non-onerous standard set in
the memorandum.
My regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>February 19, 1971
Mr. Demetri P. Kenellakos

Stanford Research Institute
Park, California 94025

Menlo

Dear Mr. Kanellakos,
Thank you for your survey of the literature on ”Voluntary
differences
It is clearbethat
Improvement of Individual Performance".
but
defined
TM
can
and
other
states
between the measures during
defined.
be
to
their regularity and significance are yet
I found your review most
Many

thanks.

If

helpful.

you can, give

my

regards to

Lee

Otis.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>June 23, 1972

Dr. S. kanowski

Freie Universitat Berlin

Nussbaumalee 36

1000 Berlin 19,
West Germany

Dear Professor Kanowski:

I

am

most

interested in your studies of blood levels of Perzin

years ago, Itil and I tried such a study of
failed to find a correlation but thought this may
butaperazine.
have resulted as much from the problems of measuring blood levels
as from the EEG measurement. In our studies of cycloserine, we did
find blood level n EEG correlations, and others have reported similar
correlations for lithium.
and

EEG

effects.

Some

We

The

reports

you requested, and some others which may be rel—

evant, are enclosed.
Many

thanks for your

interest.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                    <text>Hovubor 3rd, 1972

Prof.

331°.

3.

march,

train Uninnitit Berlin.
Payehiatriooho and Rummage» mum:
1000
Berlin 19.

und

Poliklinik.

Huslhnunlllea 36.

W.

E

_

,

.

Gamay.

Dounacter'nnanki,
The proper

vzmzwg

-

a

antics.

fur the that: reports

than: you

u. follow:
Fink. m. sac Clnltificjtton or Pnyehoaetive
(Impound: in ma: Rum: and Theory of Behavioral
Associations. Psycvhophmmaology - A Ravi-v of

rcquutcd

$674987, can.
Ema, J. Cole, J.
Wu,
Levine and LR. mtmbcm, v.3. Govt. Printing
D.

Office. wuhimon, 13.0..

‘r‘-1',VWR?"‘\;&lt;VWDM‘:§!‘ﬁer'w'5'?,:241er'"11

PP. ”97’507’ 19690

ﬂak. M. and 11:11. '1’. m an! Hum Psychophu'ucalosy IV: Clinical Antideprumtn.
Ibid. , 671482. 1969.

.Ww‘J'zﬁv—mw

mm. It. and

of the
lam-Wiener
19690
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.

11:11. T.

I look forum to toting

it is M11011“.

W

I.

can of thituport

but "suds.
smartly

m

mu,

rm. "on.
Professor of
MF/iﬁ'

when

thintry

�</text>
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                    <text>September 15. 1964

Louise Xanter. Ph.D.
Research Assistant
Bureau of Planning

State of California

Department of Rental Hygiene
1500 311th Street
Sacramento. California 95814
'

Dear Dr. Kanter:

for your recent inquiry to my former office
at Hillside Hospital. I do hot know exactly which projects
carried out at Hillside seem related to the problem of treet~
tent of low income and minority groups. The closest study that
we have is one comparing the differences in psychiatric treatment in three institutions, and I am enclosing a capy of that
nimeogrephed report.
Thank you very much

of the ataff who has had the moat experience in the
sociological factor inoour treatment programs is Dr. Robert L.
Kuhn, now director of plychology at the Montefiore Hospital,
The number
Gun

Hill

Road and Beinbridge Avenue, Bronx. new York.

also wish to write to Dr. Nathaniel Siogol at Hillside
Hospital, who may have carried out some studies subsequent to

You may
my

leevins that institution.

Sincerely yours,
Fink,
Director

Max

Dir/5b

H. D.

�</text>
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                    <text>March

1’4

, 1967

Dr. Martin Kantor

15'4
New

Fast 7lst Street

York,

New

York

Dear Dr. Kantor:

AsIdiscussedwithyoueomenmths ego, theDepartment
isemmmdﬁgammberofﬂnstudypmgxamsmﬂwewouldbe’
pleasedtoomsideryom‘appoin‘bmnt. Mover, I anoonoemed
withywrrequest fora "parttimeposition at 10 20 hours
permek."
At the present time, we are not making appointments for
staff with oomxitments less than 25 hours per week, giving
priority to attending psychiatrists willing to devote 30 to
—-

MD

We per week.

.

If the possibility of a more extensive ommitment to the
is of interest to you, I would be pleased

Department's program

to have

you

call Dr.

Gerald Tarmnbam

at

369-6300 Ext. 75H.

Dr. Taxmenbaum is in ohmge of one of the special projects
in brief hospitalization with visiting nurse after-care. This

progremisanexoitingreseamhstudyarﬁlthinkyouwillfind
participation most interesting.
I look forward to a fayomble menstruation from Dr.
Sincerely yours .
'Max Fink, M.D.

Professor of Psychiatry

MF:kp

cc: 1'». Tannenbmm

Tormenbaun.

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                    <text>m: ww-n-a"m.1li wwwvw-y-rra-H van—spew

W‘

.-...—-

-

'

'

:amrm'w

-.

vmﬂmnrmv

WWW

January 6, 1989
Shepard Kantor, M.D.
310 West 86 Street
New York City 10024
Dear Shep,

..._...._.m,.

...

it was good of you to send me the material on the role of oxygen-freeradicals (OFR's) in brain functions, and specifically in affecting the cognitive
effects of ECT. I did not know these findings and so read them with much interest.
There may be merit in your suggestion, but only systematic study (as you propose)
will tease out the support for these views.
My own laboratory is devoting its time to study the mechanisms of action
of ECT, mainly the neuroendocrine effects of seizures, and it is not possible for us
to deflect our energies to this interesting clinical question at this time.

Thank you for sharing these interesting ideas. My best regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>January

20 , 1966

um Abmhm Kaplan

Alger Road, King Point

met Nedc,

New

York

DearAbe,

hertha has told me of her pleesmt visit with you last week
end. In her whirlwind tour of Westchestsr Comty. she case back
with some very definite impressions. As we now see it, although
living in Westohester Oomty would be advantageous from the point
of View of traveling, the chmms of finding a satisfactory house
in that part of the cctmty (Lemhmnt, Rye or Scarsdale) which
would insure the shout traveling time, is highly mlikely. So,
we are leaving our hone situation flexible. I have spoken to
Bertie about homes in Greet Neck and she will cmvms the field

sothetﬂnnlmxtcmtoﬂewYorkIcmlodtthemaswell.
Wily,
boﬁaﬂerthemdlwculdwmtverymdutolive incur
foxmr enmity. The cmittnent to tmwling to New York

mgulerlyissomsmtomthatlmdtodismgsrdellﬂm

advmtegesoflivinginematbieckwlmnlhavetobelsncemse

against the traveling problem. Mover, this is but a small

problem facing us today.

the

‘

I met

NP

thank you for your valiant efforts on my behalf with
Society. I was am that this suggestion had fallen

W,

emptthatherﬂutoldmthetyouhadmceivedamittmntmev
Minhemh. Mmmiwtedinywmte thatthe problem
was a title and subject that mold ”sell” I was stymied. Nothing

Mmhavedcneinthepastthmyemispopulsr.
Ibelieve,
that we have «accomplished
but
in

however,

of the discipline which has

mm,

it is

those aspects

little direct relevance to the

practice

ofpsychistry. Pbstcfamworkhasbeenintlmmemntofthe
chronic eduixophmzic. We have examined the nemphysiologicel
cl'umges which: we think are newssary for the memm: response

mdhmmedthesemasures

essuidestothemamntpmm.

Inpatientsuwhawfailedtomwndbyothertma‘tmentmtmds,
czar

use of very potent plumthiasines, hallucinogem, and contained
drugs has been successful. In these studies . we have learned to
apply potent dmgs to chmge the behavior of the severe mentally
I believe that these studies have been met helpful to
in assessing the treetmnt program for individual patimts w mthey
have can to our unit. Instead of facing a plethora of drugs and

ill.

�Dr. Kaplm

Jmmary 20, 1966

~2~

«tam-1mm fermions aboutwhidm
drugtom.wmabletomwsmb&amp;aviorofﬁnpatiant

mthavingammmable

mdﬁmuloatwwmmﬂngtopmr,ﬁumtimm

WWW.
Aseomdamofatudyhasboenmassessmtofnewmds.

Msmmmmminmofmmmmly
in,mmoiname£mlymmdpaydamics. magnum
mthmmmbmamtmﬁnsmmﬂospitalmmmm
commitymitals. Inﬁdspmmmhavelemodﬂmtmof
tmdhawtriodtoavelop
mmmomdsmhmd
mummnmhwe developed
Mien: formapplica

smmmwmmmdasmsingmmm.
..

mmmmtmmnﬂmeffmdhﬂlmm

mpatinnm. Wahnwduuammrofsmdiumﬁueffecmof
Wemmdpmlmgadeffcctsinaam
Qumran)».
Whmobsamdmedewlomntof
apatimm.
sv

metm.
mumammmmmaaﬂw.

Wmdhaw‘stwndmmhyaiologimldmﬁmt
Astudyhasmlamdﬁmlanguagn
Wimdbymb’mmnwmpmmiomcaldmmd
mdwuwmmhasMMapaparmmmmimo!
wally.

www.mmofamm
fwmasming
us.

mmtolinioal.

Wehava chmlopedm’chm

the
Mommies:
possible tha

m
War
We
ch makes
atrium
«mm,
91’ articles fm our files which we mlaﬂd to
Wiccam
the problem of EEG. paydxopimaoology, and bohavior. Reaction
using ample:
system has been

11:

hawbmdmemdtedmiqma
mam
mm effects.
drug

,

An

developed

formanwing

.

is enough to ﬁve you a picture of
SM
marmhmm,mdmyofmsesubjamemidgﬂw
basis for a diacussim. Wing the Mn of the society,
Iwmmsubjammmdboofmtimdiam
I believe this

mummidbamepmbmofovaluaﬂm

ofmwdmgtmatw

mummnmﬂummmmmcmldmmmmﬂm
The second
aelwtim of druga for different patiant
mum be a discussim of

maps.
In19600r1961,1d1dpmsmtscm

LSD.

taminsodntybyaﬂm.

Both

subjects ham been pmsanted

ofﬁadatamgudingtheoffomofpsycmtmpicdmgs. Ids
mthmwheﬁmrmmofﬂmsmtyissumﬁmtﬁmywould
in mom dismaion of psycbou'opic drugs at this
be
tin. mmifitwwldbcgfinmmst,1wouldbepleased

5.an

mmmmmssuymmts.

�Dr. Kaplm

~3—

'

January 20, 1968

Ith,thatwmIspoketoyouinDemeaapmmhdbynymoblmofmmmmmmmmtomaww
tomakeﬂnmtoweatm mmm,wmn1hmm
Wtytomwlboﬂxmmkdcmdmmndngw,r
decided ﬁxatthmritmldhawtobe. New, 33.31.31.133:

Maid”. Idonotﬁxinktlmtwparticipatiminﬂmksswﬂ?
SocietyH-omwinmdifywdocieim. Itwaskindafyouto
mmhnuiriasmwwmlf. IbelievuﬁmtifﬁxeNPSociety
hasmopportmitytoinvimampopularspoakcr,ﬁmyalmld
dose. IwillboinNewYorkfmeon,mdwou1dbeploasad
NP

to participate in the Society Program wmmr I live in Westminster
«Nassau. Imtlommdacinimuptoyaumdtlangm-m

With...

Mslatterismmhlmgarﬁamlhadoriginénymicipmd

mwiwinaloaeuimwmymmmdtelmugyoumtl
lodefoxwazdwrymmspendingmﬁminmtﬂeckﬁﬁs
manner.
mkstmgmtoSMr-lay.
31:109me yours ,
Max

Fink, PhD.

Professor of Paydliatzy

�</text>
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                    <text>Jamary 21,

1986

Dr. Abraham Kaplan
Alger Road, Kings Point

mat

Neck, New York

DaarAha,
Martha has

told

me

of her pleasant visit with

you

last

was):

Inhermirlmmofmtmurmty.ahemback
withmvexydefirdteiwmam.
Asmmwaeait, although
in Wastoluater
and.

living
County uzmm be advantageous from the point
of vice: of traveling, the changes of findim a satisfactory henna

inthatpartofthemurrtyﬂamimnt.ﬁyeor80mdale)which
immthesrnrttmveling time,is highly mailmly. So,

would

mamlamimmmmaituation flexible. Ihava spokento
Bartieabouthamsinmathdcandshewillmassﬂmﬁeld
soﬁxatwhaanctmmNewYoﬂcIoanlodcthmwwan.
Prunkly,bothMarthaandeou1dwantvexywchtoliveinmm

fwoommity. mmmﬂttomlingtomwi'ork
mgularlyissoammtomthatltexﬂtodismgardalltm

advantagasofliviminWtNeckwhanIhavetobalmmﬁmse

mimtthatmvalim

pmblam. Homer, this

pmblanfacingmtoday.

is but asmall

Immatyouforymmeffortsmuybmlfwiththew
1m amuthatthis mationhadfallen thmugh,
amsoIdidmtmspOMtoywrmteimdiatcly. mthirgm
havedomis"pcpulm~." Also,themlthixﬁ&lt;ofit,and
moognizimmelargomuntofwoxkfacingmetoday,1mt
aakywtotauﬂmommittaemtIcamtmkaitthissprim.
Society.

(Ifﬁmisisatanembamsaingtoyou,1willcallAbeortm

Presidentaxﬂexplain).

children are fine. as Martha mt have told you. Despite
Imayhaveanopportmityto
attend the International Psyomlogical meetings in macaw in August .
The

Welseforthissmr,

ImbdAlifhawmﬂdallouaﬁmemektripsoeaﬂyinmy

mar.
andhaappmvadprwiﬂdeaabackaarlthomver
for‘himdmimhis visit mm. 80, Martha-MI talkedabwt
it and than invitad Jmatmn ("if he wantad to go” "Am you kidding?
I'd

me

rather go to Rumpe than aanp"...). So, we are planning
the usual Semxdinavian-Russia~ﬁnkay tcur.
Keep up the terminal. and my best regards to Shirley.
01?

-

Sincerely yours,
Max

Pixie, M.D.

meesaor of Psymiatzy

�</text>
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                    <text>-.»

A

‘7‘"

.wymww&lt;v.muwn—mm

Jmo 12, 1963

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Alex H. Kaplan. Mm.

Psyohomalytio medatim of St. Louis
nszu Forest Park Boulevard
St. Louis, Missouri 63108

Beer m». Kaplm:

Wmverywdifortheinvitatim tomat

attendalectumbynr. Siﬂu.1mgret,hwever,
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Univemity the sam afternoon.
Thmk you

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Sinmly‘ym,
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mf/ls

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Director

MOD!

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                    <text>r“. W,,,

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,

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. we ..._ .

.

M

’w-W,_mnu._ww .w e—inww—n—r W

Wr'w—v-«mm‘lﬂ-v-mm

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m—mmmAW—‘VW~N,—

April 28,1969
Miss Ellen Kaplen
E. R. Squibb 3 Sons. Inc.
909 Third Avenue
New York, New York 10022
Dear Miss Kaplan:

is

a revised summary. including all the
you suggested. in only one instance (VI) could
I not follow the suggestion - and this because my notes
indicate this to have been reported. and not to be in his
be from another reference of
written report. Could
Simpson's not known to me? Perhaps you would send the
paragraph to him for his comments.

Enclosed

corrections

it

I presume you

don't wish the xerox copies of the
if so. they are in the file.

papers returned. but

Sincerely yours.
ﬂax Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>I

l
I
E

P

x
x

March 7 , 1959

Dr. Helen

:3.

Wt

Associate

Kaplan

meesscr of

Psydmiatry

of Psychiatry

New York Medical College
5 East 102m Street
New York, New Yam 10029

Dear Helen,

thoroughly deligl‘lted to have the opmrtmnity to
prepare a sectim on "EEG in Psychiatry" for the. second
edition of the Commehmiue Tex/time}; 05 PA gravid/Ly.

I

am

I

assume

that the dates for this material am

as the section
My

best

cm

”Ccmmters

smci

Paychiatzy."

the. same

team .
Sincerely yours ,

.we

"-4,."

.r-

Yrs-mu

Fink, PM).
Pr'ofassor of myCMatw

ﬂax.
m1!"'wfwwwvv

‘lllrw'zm'rv—xwrv-

urn-

“W'l

-r

wmu-mv

:

W,“

mwﬂwmv'm

v-nw

HF :kp

�</text>
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                    <text>Krm—w—tw.—

May

i9, i969

Miss Ellen Kaplan
E. R. Squibb &amp; Sons, Inc.
909 Third Avenue
New York, New York l0022
Dear Miss Kaplan:

in rereading This summary,

l

became concerned

lbs?

it

The Topics were covered in a haphazard manner, making
difficult for The reader. l have had fhe paragraphs re~

constifufed,
i

am

and

frusf fhaf This is heifer.

assuming you will add fha approprlafe references.

Am i corrocf in assuming also fhaf you will publlsh
tho compiefe reporf of our studies, submlifed under The
Title "Depot Fluphenazine in fho Treafmonf of Psychosis

in a Communify Menfal Health Clinic," by Luigi Bucci, M.D..
Marla Fuchs, M.D., Jovan Simeon, M.D. and Max Fink, M.D.?

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

enc .

�</text>
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                    <text>Detour

26 , 1965

Dr. Harald Kaplm

Meal

York
Collage
5th Avenue at 106th Smut
ﬂow York, Haw York 10029
New

.Daarﬁamld:

SW"

copies of
Chapter "Orgmic Treatment
m two
for tha Wmivo. Tcubook.
haw triad to fulfill the space mulmts as you
suggested and the nfomnm follow the indicated
stylc.

of

Enclosed

1310‘

We

I want that this dupterlus bum (blag/ed, btt I

hope

ﬁxatﬁxiswinnotimdampmtpublimtimofﬂwbodc.
Mybost

mm.

,

Sincerely yours ,
Max
V

Fifzkp

enoloom

Pink,

14.13.

Professor of Psychiatry

�</text>
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                    <text>Jum 3,

h”. Harald

I.

Knplan

Dimtcc of Psychiatric Training

New

York Medical College
and Fifth Avsmas Hospitals

6

1965

Education

Elm

Street
Am at 108th10029

Fifth

New

Yank, New York

Dem Harold:

'

Eclossd are the contracts aimed by Dr. 11:11 and his
identification for yam records.- I an grateful that you have
accepted his ccllabcs‘tim for I believe we can do a better
jab together.

Imidem'ally,

designation for

my

would you

lava your secretary

appoinmts to read:

cmct the

Professor of Psychiatry, Department of Psychiatry

at Miami Institute of Psychiatry, University of
Nissan Sal-col of Micine; and Research meesacr
of Psychiatry, Washingtm University School of

Mickie, St. Innis, Nissowi.
Imdvsrmmly, the

title

peated once too oftcm.

“Professor of Psychiatry," was
Sincerely

re—

yam.

that Fink, H. D.

Professor of Psychiatry

Hszp
co: m‘.

Itil

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Dr. Harold

I.

Kaplm

Profusor of Payahiatry ma
Binder of Psydximic

and waits:
Wing
Yuk hdieal College

New

Am 3391211313
Fifth Am at am
and Sixth Stmat
Flavor ma Fifth

New

York,

New

am
M 10029

.

Boar Hamid:

Aslwmﬁatontwomksago,ﬂnmmeriptyoum
wanting for the term is not yet caplet: but will he
sonttoyoubyOatobor 10.

MugJulywemm ablateMempmliminar-ymtes

MHz-imashmtdmft,butwrvwmimsmduringmt
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gomrﬁwmmwiptmdfarmtommmmas

smpmper.
I m sorry that my new to Alfred whim indicated the am
aunt
ww
timtabla

mt

to you.

I hope that this is satisfactory.

Simmly yam ,
Max

Pink, NJ).

meesaar of Paydaiatry

Hfzkp

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Dr.

Haw

Mold I.

mm

York Medical College

Fifth Amue at 106th Stmet

New

York, than York 10029

Dur- Harold,

Wt

SmmkaagoAlahmdwithmmcr-itiqmofﬂm

of 3611mm." Dr. 11:11 and
chm!" "Organic
me?
have
secticm as you have wanted. We have
I
condensldtl‘nlaatpu't, ﬁxemodeofactim,totw0pa
Ifthisisstilltoolmg,ﬂmexpmsaimoffaithsahidm is

meta

mkstpamgmphmybemdﬂydehted.
The citatims ham been reduced
style you requested.

V

in amber and follow the

’

has apokm to an about the possibility of mother
EEG in Psymiatzy which my mlify in
whim wen deleted. I told him I
mien:
would b: pleased to masks such a mission near the and
A1

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section an
detail the

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of Jam.
My

best mgarda for the

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811103me yours.
Hut Fink, FM).

Professor of Psychiatry

24mm

�</text>
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.

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p -:v~ ‘IY'V" wm‘ww-r'wm"‘

"-v-

“a;

January 30. 1968
Dr. A. Karczmar
Loyo1a University

Stritch

Schoo1 of Medicine
Hines, I111nois 60141

Dear Dr. Karcimar:

P1ease rep1ace the 1egends by this page which has two

corrections.

Sincere1y yours,

Max

Fink, M.D.

Professor of Psychiatry

MFtkp

,

mwzg,

�</text>
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                    <text>,

at“

an

—,

.r‘

.-..-,7.-.

meq-uuc—

ﬂanuary 29, 1968
Dr. A. Karcznar
Loyo1a University
Stritch Schooi of Medicine

Hines, I11inois 60141

Dear Dr. Karczmar:

Enciosed

is

of Cyciazocine.

that:

Note

A

draft of our report.

a revised

Narcotic Antagonist." and

.

"or.

#0353“

0
o

a

050'?

o

a

Patterns
additionai figures.
“EEG

Authors - revised

Credits
Pages

—

4—9

revised
- revised

Reference pg. 1.

citation

Freedman gt_gl; - updated
Figures added
Legend added

Please revise the draft in your hands according1y.
Sincere1y yours.

Fink, M.D.
Professor of Psychiatry

Mex

Mszp
GRC .

.
q.

WVMWW

'

‘

�</text>
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                  <elementText elementTextId="103706">
                    <text>zhh?

tsan~55acw
February 27th. 1973
Dr. A. G. theznnr.
Depurtnent of Phtrneealogy and

Instituxe for

Mind, Drugs and Behavior.

W. Illinois

bowel; Uhivernity Medical Center,
60153.

Deer Alex.
we have had tun reviewers reed your report "Bruin
Acetyleholine and auteuree“ which you submitted for the
EC? volume. he yen know, the substance or the report is

ingortent

end

of great interest.

The

presentation was

diffieult to fellow however. since the written text
lean: to fellow the verbal presentation. Lacking your
chility tO'emphasize, we have fbund it difficult to
fellow, and have taken the liberty of making some suggested
changes. I have bed the text retyped and enclose your

meet

eriginel edited copy and two xerox copies of the retyped
I would be most grateful if yen venld reed

vernion.

thin promptly and make such eorreetione as
return it to me within ten days?

Gen you
my

you may wish.

best regards.
Sincerely yeure,

ﬂux Fink, M.D.

Profeeeor of Paychieery

hilt:

“.0
cc. to Dr.

8. Katy

�</text>
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                  <elementText elementTextId="103148">
                    <text>p1

‘- . M.

J». mu...“ .,...—".mw.~...~,~

”mu-ww_~..

v.vr»-:—~~.v..-...~.Ymr..

rm

.7,

"WWW- ..

_.

...,.-....... ..

.

_,

.,_.r__,,,,_ .. ‘.__....._.,...,.,

,~__

,

_.

....

... ..

..

,....

.

v..." .. w.

December 9, 1969
Dr. Alexander G. Karczmar
Department of Pharmacology and Therapeutics

Loyola University, Stritch School of Medicine
Hines, Illinois
Dear Alex,

for the project outline which we
ﬁartin Kate was here yesterday and
received in time.
seemed sympathetic to the suggestion that we expand our
ECT study program. However, he indicated that if at all
possible we go through the initial steps of demonstrating
the feasibility of shipping fluids and having them analyzed
Thank you very much

Dr.

in Chicago.

.

Dick Abrams and I found our discussions very useful and

like to carry out some initial steps before applying
definitive project. It would be useful to go through
the step of collecting spinal fluid in Mew York, shipping it
to you in Chicago and asking for some preliminary assays,
particularly for assays of such substances that could be done
in New York as well, to determine if shipping is feasible.
Is this step necessary and if so, we would like to do so.
would
for a

—

How?

like to attempt some spinal taps in the
next
patients at our hospital and see whether this
is feasible.
We

few

would

If the fluids are available

and shipping

is feasible,

can then proceed with the application. In the meantime
write up the literature review and theory.
My

we

we

will

best regards .
Sincerely yours,

at...

at

amaze.

1124-1;

'-

Max

I.”

Fink, M.D.

Professor of Psychiatry

21
w;

11'";

“7,

rum».

‘1

fWWu-IWW¥W“W4

$77712???

III-8““‘K‘Y‘V

mw

Hszp
P.S.

in Mexico City Dr. Aprison described some new
techniques for acetylcholino determination, citing Lincoln
Potter, J. Biol. Chem., 1968-69 and Feigelson and Saloon,
Siochem. Phanmaco£., 1968. Perhaps these are useful.

At a meeting

l

v,”

.

_. u.

.

�</text>
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7,.

-—

A

A...

wwmr—m.

".Vw.w—~W——v—w—w~rn-mwvw

November 12, 1969

Dr. A. G. Karczmar
Pharmacology and Therapeutics

Loyola University

Stritch School of Medicine

First Avenue
Hines, Illinois 60141
1400 South

Dear Alex,
I look forward to welcoming you in New York
Movember 18, about noon. May I suggest that you

to LaGuardia and a taxi to our offices at 5 East
(corner of Fifth Avenue).
I have asked Dr. Abrams,who

is

my

next Tuesday,
take a flight
102nd

Street

co-worker in the project,

and Dr. Ehrenpreis, of the Department of Pharmacology of the

New

York Medical College

to join our discussion.

would like to focus our discussion on the biochemical
aspects of the convulsive therapy process. I am particularly
interested in assaying cholinergic mechanisms, possibly in the
spinal fluids, in patients now undergoing selective varieties
of induced convulsions.
I

Dr. Abrams has just completed his residency, but did have
two years of military experience and so is Board eligible.
Dr. Ehrenpreis is noted for studies of acetylcholine.
we

will, of course, defray your expenses

honorarium.

I look forward

to seeing

you.

My

and provide an

best regards.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

.

uku—u—

MF

:kp

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                    <text>March 4, 1970

Dr. Alexander 6. Karczmar
Professor and Chairman
Department of Pharmacology and Therapeutics
Loyola University, Stritch School of %odicine

Chicago,

Illinois

Dear Alex,

to

Enclosed

NIMH.

is

a capy

of the supplement application

Dr. Abrams is looktig for a suitable
touch with you as soon as he finds one.

subject

and he

Sincerely yours,
Max

Pink, M.E.

Frofessor of Psychiatry

MF:kp
BBC .

as we submitted

will

be

in

�</text>
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                    <text>«equw-r-au

~

mgmrwnvmmgv

nun-‘3.

cur-\—

rw

ﬁi'wﬂlw

nan-"Iv

Ms...

July 3,

1970

Dr. Alex Karczmor
Stritch School of Medicine

Loyola University
Chicago, Illinois
Dear Alex,

notified by EIMH that our application for
supplementary support [or the studies of CS? in the ECT process
We

was

have been

not accepted.

Dick has sent one sample, and during the past 2 months
we have been writing up the results of the first tsudies and planning
the new ones to begin'in late September. I do not know what
arrangements we can make, but I believe that we will be able to make
samples available and hope that we can work something out.

I will call

and we can decide then how
My

after

return
to proceed further.

you immediately

best regards for a

my

from summer holidays

happy summer.

Sincerely yours,
Pink, 3.9.
Professor of Psychiatry

Max

P.B.

we

should have a dinner in Prague, at

_

least

1

W

�</text>
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                    <text>September 25. 1968
S. Karger AG
Arnold Bockiin-Strasse 25
BASEL 11

Switzerland

Gentlemen:
Enclosed are the revised page proofs.

The oni

significant

correction is in the citation for Fink, M. (5, 1964 which should
read; Eiectroonceph. ciin. Heurophysioi. Suppl. 23 (1964).
Thank you for your comment regarding reprints. Unfortunately.
I have no record of requesting reprints. We do wish to order. at
lease 100 with covers. and wouid request your sending me the
appropriate order bianks so that this can be completed. If I
already signed one. would you pioase send me a copy and I wiii
have the appropriate orders made up.

Piease excuse this extra probiem.
Thank you.

Sincereiy yours.
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>April 29, 197k
Mr. Herman Weissman
Hoffman— La Roche Inc.

Nutley,

New

Jersey

07110

Dear Hank,

Enclosed is an original, unbound copy of the report
summarizing our experiences in assessing the EEG profile of
bromazepam and its comparison with diazepam and placebo; and
the blood level correlations. I am also enclosing three bound

copies for Phil

Bookman and

other associates.

Please be advised that the original data of the EEG
assessments, behavioral observations, and subjective data are
in our files and may be made available at your request.
I want to take this opportunity to thank you and your
associates for your cooperation and patience during this study.
I believe we have made some progress in characterizing the pharmv
ecology of these compounds, and in the process, we have learned
a great deal about our methodology.
My

personal regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>October 29,
Robert

Kerk,

M.

198‘}

H.111.

Presbyterim—St. lake‘s Hospital
1753 West Congress Paﬁwsy
Illinois 68612

Chicago,

W:
reply to yum recent letter- of October 26th
In
mgsrdingtheststusofmv.A.M.Dm,Iesplessedto

Dear Dr.

‘

state tint'deeMissmmi InstituteofPsydeistryetﬁee\
St. Louis State lbspital is Waited by the Mariam

Boardefhydeietrymdﬁemlogforafuntrainingpm-

psychiatry. 'meInstitutehasatthepresenttime
min
nieeeteenmsidmtsmminingineadeoftheﬁemeyears

W

In sdditﬁm. participation in the
of this ﬁestitutim have been accredited by the boards

as

clinical experience (sedit.

InhisappoinmntassseniorResesthcien‘
tint (Psydeietry), 30p. Don is responsible for the care
of a lied: of patients within ﬂee Institute and for the
supervision of all of the stuﬂstsin those patients. At
the mtitim, he is actively imolved with a group of
psychotic patieets inwhemiee is messing avariety of
mmdesteblishedthemyssasms. Inthisrole, he

supervisesraseardenurses,wardnurses eedsidm and
attendeets. Inaddition,heisaommﬂtsﬂhtothe0niveru
sity of Missouri School of Naming affilisted nursing pro-—

mmdinthisrolstesohesanmd‘Myesr-ming
in the
an aetive
students. He also
is

pertieipsnt

resides.

whemheisasuperviswtesnwber
cytraininng
of resident trainees. In this role he supervises their
clinical activities.

I trust

We

this information is of weisteeoe to
‘

'

'

Inf/ls

_
_

.

Sincerely yours,
Max

Fink,

Director

31.3.

,

�</text>
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                    <text>April
Miss
.

3

, 1967

Phyllis Karliner

Laura Scales House
Smith College
Northampton, Massachusetts 01060
_

Dear Miss Karliner:

I have discussed your request for summer employment
with different members of the staff and can give you a mixed
answer. Your request for a clinical assignment may be fulfilled 9
but I cannot do sowith assurance now. If you are willing
to
accept either a clinical or a academic (non-clirﬁcal) assignment, I am prepared to recommend your appointmnt during the
summer period, effective July 1.
established college salary which

New

The

is

If this is satisfactory, call

York and

I will

Thank you

salary will

be

the

approximately $60 a week.

me when

you are next in

the necessary arrangements.
for thinking of us.
make

Sincerely yours ,
Max

ka

’ M. D C

Professor of Psychiatry
!

�</text>
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                    <text>July 30,

1965

Dr. Willim Karliner
1N9 Grand Cmoourse
Bronx 53, New York
Dear Bill:

It was

a pleasure to dust with you, and when you told an
how extensive your present practice was , I had a twinge of
mgmt for not having continued in the private practice of
Psychiatry. Hwever, the present opportunities are still
very exciting and I am writing to ask your permission for a
masher of my staff to visit with you in September during his
holidays .

Dr. Alexander Don is a graduate psychiatrist from South
Africa. who joined the staff last year. He is interested in
observing treatment nethods not available in this city, and
so inquired as to the possibility of observing Inddclon therapy
out. With your permission, he will call you
as you carry
and plum to be in New York during the
in
September
early
period September 1% to September 21 . Pampas he can come to
visit you at Gmcie Squam on Saturday, September 18, 1965.

it

My

I

would be

best regards.

grateful

if you would

show him

your techniques .

Sincerely yours ,
Pink, 1-1.1).
Professor of Psychiatry

Mex

MP:kp

�</text>
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                    <text>..

“n.7,,

,_

,
,v

.7...”

”w

.
J...

WWMWM,

q...

.

«ﬁn.

December 20. l967
rum-v—w—rﬁm'.

Dr. William Karliner-

Franklin Rodd
Scarsdale, New York
20

s’vryvp...—

www.my—m—V

:

..

.x-

AFTIW

'.'V‘-—U~ww-VII"

Bill,

Dear

Miss Harriet Bernstein, age 39, was seen at Gracie Square
Hospital on December 9 and in our EEG laboratory on December l9.
At Gracie Square she presented a mild organic mental syndrome,
moderate to severe depressive state and evidence of barbiturate
intake. She was mildly ataxic, labile and her Speech was slurred.

5-1

min—va-"mw‘

when seen on December l9, she was no longer ataxic nor did
she have nystagmus. The mental syndrome had been relieved and
she appeared anxious. tense and depressed. She had a pressure
of speech.
The electroencephalogram (#039) was symmetric without evidence
of a focus. The rhythms were highly irregular with mixed theta,
alpha and a moderate degree of high voltage beta activity. The
beta activity did not appear in-spindles or runs. The frequency
of theta activity was 5-6 cycles per second, with amplitudes between
40 and 80 microvolts. The record was filled with eye blinks
artefacts despite manual control.

hyperventilation was repeated three times and on the first
she exhibited a two Second burst of 200~250-microvolts.

trials

two

activity. with spikes.

These were symmetric and occurred
In the succeeding twenty
seconds there were random S~6 cps higher voltage (100 uv) runs.

.5

cps

after

80 seconds of

hyperventilation.

This record gives evidence of continuous, generalized cerebral

dysfunction.

The

presence of spike and

is consistent with cerebral dysrhythmia.

wave

bursts

on

hyperventilation

Recommendation: In view of the history, we cannot exclude
the possibility that the dysrhthmia is related to previous convulsive
treatment, although the probability is Very small. With this in
.mind I would suggest that she be continued on Oilantin treatment
and that the depressive state he treated with imipramine. If imipramine
is given rapidly in the hospital setting, we will know if dysrhythmia
is enhanced.,if the EEG is repeated when she is stabilized at your
.

average imipramine dose.
Thank you for the opportunity.25chee/7i7ﬂxoSee7ﬂdrV’
'

SinCerely yours,

Fink, M.D.
Professor of Psychiatry

Max
.

Mszp

.

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                    <text>January 2, l968
Dr. Hilliam Karliner

Franklin Road
Scarsdale, New York
20

Dear

Bill,

Miss Harriet hernstein had a repeat electroencephalogram
on December 28. The record indicates that she received dilantin,
390 mg/day and Tofranil. 150 mg/day. She appears less depressed
and is in good contact. Emotional lability is no longermmanifest.
The electroencephalogram was repeated (#406). The rhythms
were symmetric with the same amount of alpha and beta activity
as previously. The amount of theta activity was increased and

the beta activity

was more prominent

in all leads.

0n hyperventilation, high voltage spike and wave
activity
appeared for let seconds after 180 seconds and after llO seconds.
There was no additional seizure type activity in the record.

There is no evidence of increased seizure

result of imipramine.

would suggest

it

activity as a
status,

In view of her improved mental

that she continue

on imipramine.

In the event that you plan to discontinue her medications

may

be useful

to repeat the

dose of imipramine.

EEG 7 ~

l0 days after her last

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

I

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