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                    <text>February 23, 1967
Dr. Souren Avakian
The Denver Chemical Manufacturing Company
35 Camerce Road
Stamford, Connecticut
Dear Dr. Avakian:
Thank you very much for your kind invitation to join the
membership of the Carl Neuberg Society. The invitation came

as a surprise as I have not participated in this sociew in
the past. The content of the forthcoming progran of "Drugs
and Dreams" is indeed of interest.

waver, before undertaking to accept your kind invitation,
itmuldbemosthelpﬁzlifacopyofthepresentnmnbership

list could be made
Again,

my

available.

thanks for your kind invitation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

'

�</text>
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                    <text>December- ].u, 198*:

(males
85

H. Avery, M. D.

«Items: Smot

Hartfom

1%,

Gem.

W Dr. AVG”:

is a

of the unpubliarmd manuscript on
dmlommzhn-pmoycﬂdim summation whidm you mquaatad in
your letter- of Dem:- 8th. I m intomted in moving, howof your informatim that tit-is
exists.
ever, the
Enclosed

am

copy

maipt

Sincex‘ly yours,

M! Pink.
Director

“.13.

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                    <text>«us-yuww—

w

~an ---—~—-mv.»_ "1.ku

v.-»;....w-~

1‘

ﬁZV'I‘WI'ra-ﬁp-aruw,-n-r;vo‘~;nxx’wwrnzrnw'Wnn—wv

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MW

New...“

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7.

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.,nnm~.1.-.w~.-wmw.mr

November 25, 1976

Dr. David Avery, M.D.
VAH—

Palo Alto

California

94305

Dear Dr. Avery,
Than you for sending me the preprint of your report,
"Electroshock: A Lifesaving Treatment Shrouded in Myth". It is
well written, and makes good points in the issues that have
confused the public. I am not sanguine that Psychology Today will
publish it, but perhaps their editors are less biased than I

think.

I am impressed by the figures that are included. I
presume these come from the manuscript on the efficacy of ECT and
antidepressants. The figures should have the actual articles cited
from which the data are derived. If these are not from that article,
rather than
then they should be prepared for the psychiatric press
‘
the public press.

I could not find citation 36: it seems to be in error.
of the others are incomplete, but completeness is not necessary
for the lay journal.

Some

Let me also congratulate you on the fine review that
has recently appeared in the Archives. The analysis of deaths with

EST and antidepressants
of my reports in press.

is

most

useful

and

is already cited in

two

I do hope that you will continue yuur interest in EST. The
Task Force on Convulsive Therapy has been reviewing the evidence for
safety and efficacy of EST, and we have found a number of problems for
which the evidence is lacking. It would be good to have another unit
carrying out the kind of careful studies of EST suggested by these
reports. If you come East on a visit, come and visit us at Stony Brook.
We are developing a study team for EST research and we would enjoy
APA

meeting you.

My

your other

please send

thanks for the opportunity to read the report and for
efforts. When the antidepressant review is available,

good
me

a copy.

My

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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-

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an...“

..

.mpwwvwnwv

.7

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Q

3W

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‘1

w.”

.c

April 11, 1978

.

.

urns-I'm)..-

WW.

Mr. G. S. Avery, Editor—in-Chief
ADIS

Auckland,

New

Zealand

Dear Mr. Auery,
The

report

on Minaserin

written

by Brogden, Heel, Speight

is well done, and I find little to modify. There are some
errors in citations which I can bring to your attention, but the
sense of the text is consistent with my experience with mianserin.
and Avery

that could be modified has to do with the
screen and how this led to the study of
mianserin as a thymoleptic. EEG analysis as a basis for the
classification of psychoactive drugs has a long history with some
definitive studies in 1961 and 1963 published by myself and Itil.
In the mid—1960's, we saw the possible usefulness of the classification
in predicting the activity of new drugs and the first studies were
done with such drugs as fenfluramine, cyclazocine and doxepin. In each
instance, the EEG screen was a better predictor of the clinical
activity of the compound than the animal pharmacology. This was
particularly true for doxepin, whose pharmacology was scan as anxiolytic
in the early studies. Our study found it antidepressant, and since then,
this view has been confirmed. Based on these data, I recommended to
Organon that new drugs be screened and in 1970 they sent a number of
compounds to Itil and myself, than working in separate laboratories.
He found mianserin to be active and its profile as a thymoleptic led
to the subsequent development. Even after the EEG screen and clinical
trials, the pharmacology failed to meet the accepted thymoleptic standards.
The importance of-the EEG screen could be emphasized, because, as Dr.
Itil noted in his 1972 paper, he 'discovered' its thymoleptic activity.
One emphasis

significance of the

EEG

As to the citation errors-~ I note that Fall et al are
dated 1972 on page 6 and 1973 on page 7. 1973 is correct. The citation
is lacking in the citation list. Also, there is a citation to Pink
at al (1977) on page 6, which is lacking 6n the citation list. I enclose
a cepy of the 1977 report for your reviewer to cite if he wishes.

Thank you for the opportunity to review this article
presents the data in a fashion similar to my view of it.

Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

which

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                    <text>May 30, 19 88

McAipin Award Panel
National Mental Health Association
1021 Prince Street
Alexandria, VA 22314-2971
Dear Panelists:

lam pleased to nominate Professor Alfred

M. Freedman for the 19 88

McAlpin Mental Health Research Achievement Award. Few psychiatrists have done
as much for the education and training of psychiatric professionals, have
encouraged such useful and important academic research, and have provided
leadership for the nation’s major scientific societies as has Dr. Freedman. His
formal academic curriculum vitae is attached, but I would like to highlight a few
aspects of his record which encourage me to make this nomination.

Formally, Dr. Freedman was certified in psychiatry and psychoanalysis
his
after
graduation from the University of Minnesota Medical School in 1942. He
assumed the chairmanship of the Department of Psychiatry at the New York
Medical College in 1960, and created an outstanding research and teaching center.
His major contributions in academic research are in the treatment of opiate
dependence with narcotic antagonists and long-acting opioids; and in his studies of
the effects of psychoactive substances on brain functions.

joined him as a member of the faculty of the New York Medical College
in 1966. At the time, opioid addiction had surfaced as a national problem. Few
psychiatrists were willing to undertake the treatment of those afflicted with drug
addiction, yet he established the first municipal hospital treatment unit for drug
dependence. He supported two separate research programs in addiction, one based
on sociological models (under Richard Brotman) and another, based on biological
models of narcotic antagonism. His program developed the merits of naloxone,
cyclazocine, and naltrexone as treatments for opiate dependence; and broadened
the applications of methadone and ievo—acetyimethadyl as narcotic substitutes. He
encouraged the collaborative study of chronic hashish users in Athens; and began
studies of the central effects of cocaine, when cocaine use was a rare and
i

occasional dependence.

addition to developing a Department and teaching programs for medical
students and residents, and encouraging the research studies, he found time to edit
the definitive Comprehensive Textbook of Psychiatry, which is now used worldwide. ile also founded and edits the journal integrative Psychiatry.
In

�Nomination of Alfred M. Freedman, MJ).

Page 2

in his residency training programs, he recognized the special needs of

women physicians, and he developed the first post~graduate training program for
women psychiatrists. lie established a Day-Hospital program for the severe
mentally ill; and has always maintained relationships with many community
hospitals for the education of their personnel. (i believe that the present program is
affiliated with 14 community hospitals).
in his support of the studies of
is not well known in this
which
pharmaco-electroencephaiography, a discipline
And
in his willingness in 1968 to
and
Japan.
country, but well established in Europe
when
the treatment was outside
support studies of convulsive therapy -- at a time
the main stream of psychiatric practice and research. That encouragement led his
student, Richard Abrams and myself, to become international leaders and authors
in ECT.
The diversity of his

interests is to be seen

His reputation in research led to his election as President of

the American

College of Psychopharmacoiogy 0972), President of the American
Psychopathological Association (1971). in 1973, he was elecred President of the
American Psychiatric Association.

Dr. Freedman has an enviable record of participation and interest in
international psychiatry. He invited leaders from foreign countries to visit the
Department and lecture, in the Goldman lecture series that began in the early
19605. He has been an active member of international psychiatric associations and
is well known as lecturer, teacher, and friend throughout the psychiatric world, not
only in Western countries, but in many developing countries as well.
Al has received many awards and much recognition for his leadership,
humanity, and support of academic principles in research and teaching. He is a
warm, friendly, and encouraging man, with friends throughout the world. His wife,
Marcia is a Professor at Columbia University, and both their sons have enviable

academic records.

Considering the long list of outstanding recipients of the McAlpin Award,
am proud to recommend your consideration to add his name to this list. i have
discussed this nomination with him, and he has agreed to be considered for the
award, and to attend the symposium in Los Angeies in September. His current
address and telephone numbers are listed in his 9.x;
Thank you for your consideration.
Sincerely yours,
(V‘ax

Fink,

649,-).

Professor of Psychiatry

1

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                    <text>November 16 , 1966

Dr. Albert P. Ax, Editor
Society for PsychophysiOIOgical Re‘search
951 East Lafayette Avenue

Detroit, Michigan

158207

DearAl,
While

I

first two iterns of your request
enclosing
items which may
interest you regarding our data processing ofsome
EEG. For the past
the
few years I have devoted mob of
my interest
the problem of
quantifying EEG changes using digital computertonethods
with specific
reference to the problem of drug response. Much work has
the development of programs and learning the pitfalls in gone into
on-line
processing.‘ I would be pleased to assist you in any way that
we can.
Good luck.
in your

”cannot help you with

letter of

October 31,

I

the

am

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

_

"1ka

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                    <text>/,

December 30, 1966

Dr. Frank

J.

6321 York Rd.

Ayd,

Jr.

Baltimm 12, Maryland
DearPnank,

It was

a pleasure to talk to you in Puerto Rico about
your newsletter. As I indicated, we are oanpleting some
studies and I am taking the liberty of enclosing pmprints

for your information.
The

thiothixene report

is in press in Omen: Thuapeuuc

Ru such; clinical laboratory test standards in the Jon/mat 06
New (hugs; the LSD town: has been published in the Malibu;
and the fluphenazine report is still being modified but the
draft that I am enclosing will give you sufficient information
concerning the stats of our studies.

Goodluckinyoxmvcntumaxﬂmybestwishesfortm

NewYear.

Sincerely yours ,
Rex

Fink, M.D.
Professor of 'Psychiatry

Mszp

�</text>
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6w:

:nuprnq-a'v.».a

—vs

January 2h. 1975
Frank

J.

Ayd,

International

Jr.,

M.D.

Drug Therapy Hewsletter
912 west Lake Avenue
Baltimore, Maryland 21210
Dear Frank,
»

Thank you

for your

letter

concerning your candidacy for

the APA. On two grounds, the letter distresses me - that the APA
presidency is politicized, and that someone without "training" in
the Job by prior experience st the APA would consider assuming

scientific society and it is
scientific societies to run political campaigns,
advertising, solicitation for votes, 335, I regret the change
and do not wish to participate in such activities. Nor do I
believe serious scientists ought to participate in the demeaning
displays required of politicians.
leadership.

unusual for

The

APA

used to be a

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>October 13 , 196”

Dr. Frank Ayd

Vaticm University
Vatican, Italy
Dear Prank:

is a mmxento of Birmingham.
attending the meeting with you.

Enclosed

It was

a pleasxme

Sincerely yours ,
Max

Fink,

Director
mf/ 13
e nclosum

M.D.

�</text>
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m...

January 7, 1989

.
m

m—p

um"?

_m

"a...

r

W'mﬂ'l‘

v-m-arrsrm

s-

«WWW

WY’

‘g’MWa'avﬁ'v—"W‘M

Frank Ayd. M.D.
Medical Communications

Ayd

Baltimore, Maryland
Dear Frank,

Enclosed is a copy of the report which we recently
published describing our experiences with phenytoin. From these data,
I think we can understand that the varied reports of the efficacy of
this compound in the treatment of the mentally 111 may have resulted from
inadequate dosage“ poor compliance with resulting plasma levels that were
possibly inadequate for the induction of changes in brain function. If
these findings are to be trusted (and I think they should be), then we
are justified in undertaking additional studies of phenytoin in cases
of neurotic depression and anxiety, monitoring the plasma levels so that
persistent levels of at least Sag/ml are maintained.
My

best wishes for

a healthy and

successful

1980.

Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

�</text>
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                    <text>November 25, 1971

Dear Dr.

Aylett,

Yesterday afternoon, the mail delivery brought your letter,
dated October 7, 1971, indicating that you would be in New York
this
week, and would like to visit. I very much regret that the letter
had not arrived earlier, for I would surely have written and made the
arrangements you requested.
For your information, the letter was postmarked Oct 8
from S.E.5; the postage was 9 pence; marked airmail-— but
must have
been sent by surface mail.

it

Should your office receive this in time to send you a
note,
would be pleased to have you call on December 10, for I will
be
in my laboratory, and would be pleased to have you visit:
call~ 212 369 8488; or at night— 516 466 5444.

we

Regretfully,
sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>May 28, 1987

Dr. H. Babikian
Department of Psychiatry
New York Medical College
Westchester Medical Center
Valhalla, New York 10595
Dear Hrair,
For a course in convulsive therapy for the residents, we propose three
sessions, each of take hours.
.

1. Seminar: History; Indications; Clinical Issues in treatment; Risks and
Side-effects; Maintenance therapies.

Videotape: Information for Professionals.
2. Technical issues in Treatment: Electrode Placement; currents;
anesthesia; high risk cases, instruments; seizure duration monitoring.

Consent. information for patients and relatives.
7 Videotape #2— Information for Patients and Families
3.,

Review.

Clinical Case Seminar:

Question Period; Case presentations by the residents from your wards; and

The first and third sessions will be by myself; for the second, my associate, Dr.
Greenberg will talk about the technical issues; and our nurse, Mrs. Irene Carasiti,
who teaches patients and families about ECT, answers their questions, and obtains
consent, will discuss these aspects of the treatment.
We will provide reprints from the literature as well as a reading list for
the latter well in advance of the course so that the materials
reproduction;
your
can be made available for the students.

if this sequence is helpful, we can set aside the time and discuss the
honoraria involved.
'

My regards.

'

Sincerely yours,
Max

seamen.

Professor of Psychiatry

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                    <text>--m

"Grovvrzwywurrw-“v

“A

mew...

mum

mu» m... ‘vW.--T-.-xttvw

In}

October 28, 1976

Hrair
New

M.

Babikian,

M.D.

York Medical College

Westchester County Medical Center
Valhalla, Now York 10595
Dear Dr. Babikian,
Thank you for your kind invitation to participate in the
series of lectures on Drug Abuse. I regret that it wéuld be a difficult
responsibility for me to attempt to present the data on drug abuse
at this time. Since leaving the New York Medical College, I have
turned my attention to other interests and I have no personal
acquaintance with the latest developments in narcotic antagonists
or cannabis-- two subjects that were my interest when I was at the

College.

I am confident that Dr. Resnick, who has sustained the program,
will be able to present the latest information on the antagonists.
Should you wish to include a review of cannabis, I suggest you call
on Dr. Rhea Dnrnbush (now at the Reproductive Biology Research Fdn,
#910 Forest Park, St Louis, Mo.) who is editing two volumes on
cannabis summarizing our studies as well as a conference which she
chaired in January. A third candidate would be Dr. Arthur Zaks.
Arthur has developed one of the most active of the methadone treatment
programs in the city. He has continued his research interest in
carrying ourtstudies of levomethadyl in his practice. He can be
reached at Flushing Queens Medical Associates, 136—80 Roosevelt Avenue,
Flushing 11354.

for

I trust these suggestions provide an adequate replacement
in the future, be interested in presenting a
on convulsive therapy, I would be glad to do what I can to

me. Should you,

program

assist.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>DEP‘RTHEHT OF EIPERIHENT‘L PSICHI‘TRY

July 3. 1962

E

5
g

Mr. Maurice Bachrach

Adniniatrator
Hillside Hospital

Glen O‘ksg Lola, N.‘Y.

Door Kauricez
member or the
to
you for the
Hillside family,
have
which
given this Dopartmont
you
pationce and support
during these last few years. For your help, kindness and
patience, I am mott grateful.
Enclosed is a copy of my formal letter of resignation,
which I am submitting with the mixed foelﬁ.ngs of regret
for our many unflllilled aspirations, and with excitement
and enthusiasm for the future at Missouri.
May I also take this Opportunity to invite you to
us in St. Louis at your convenienco. I shall look
visit
forward toasuch an occasion an an opportunity to welcome

You, probably more
know

a

friand

than any other

the debt I

owe

and ocuworker.

best personal rishes for your continued
success at Hillside, I remain,
With

my

Sincerely yours,
MFlgp

Max

fink, H.5.

�</text>
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                    <text>'1

«WP-"f
‘v-I

C.

October 8, 1962

Mr. Hauriee Baohruah

Adniniatratur
Hillsido Hoapital

P. 0.

BOX

Glen Oaks,

38

New

Ybrk

Boar Maury:

interested in knaping tha Hillside Hospittl'a
AI tho Isak: roll on, and I anxtuo-d
daily with Inny daciaiona thtt are required to establish this
eontor,.I find my experianno in Haw Yark most invaluable
espooially, sons of tha adm&amp;niatrat1vu education which I
You nmy be

scrapbook up

to dike.

-

recoivud in yuur office.

Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

max

Fink, H. n.

Director
Mrzaw

encls.

2

Addroaa correspondence

to:

Shoo Arsenal

Street, St. Loni: 39,Misuour1

�</text>
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                    <text>.H

n—ysmmvw;

Awr("w'

.

September 24, 1962

Dr. Maurice Bachroch

Administrator
Hillside Hospital

75-59 263rd ﬁtreot
Glen Oaks,

Wow

York

Dear Mourice:

it

while
will be impossible for you to forgive me, I
want you to know that I was torn between two pressures that I
was unable to be at Hillside last Friday. Before going to
Europe I moved my family, and loft Martha with painters, plumber,
electrician, as well as three reluctant children who had to
start in new schools. I called home from Munich and again from
London, and on both occasions, was disturbed to find that I not
needed at homo. I ohortcned my trip, theraforc, to arrive two
days earlier. When I got home there was much to do, and
was
only this weekend that we were able to look about us and feel

it

that

we

could relax.

In the excitement and in the mesa, both at home and
office, I put the Hillaido Hospital air travel card
aside to send back to you. I cannot find it. As you know,

in

my

this is very unlike

me.

I called

Mrs. PDdrid on Friday and
I would appreciate

asknd her to notify United Air Lines.

your cancelling this card, and notifying the credit agoncy
regarding the cancellation.
My

best personal regards,
Sincerely yours,
.IIEBOURI INSTITUTE OF PSYCHIATRY

Max
MPzau

Fink,

M.

D.

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                    <text>March 25, 1963
Dr. David Seeder

Department of Pharmacology

Mallinokrodt Chemical Co.

Mallinckrodt Streets
St. Louis, Missouri
2nd

8

Dear Dave:
were very pleased to have the opportunity
to meet your wife and your associates on
Saturday.
We had a most
leesent evening and I left with a
feeling of opt mien that there was a role for a
laboratory such as the one we
develoPing.
I look forward to working out are
a collaborative
We

relationship.

I should like to wish you

building your

new home.

all

success in

Sincerely yours.
Hex

Herw

Pink,

Director

M.

D.

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                    <text>1954

July as,

.

David

Radar,

halllntkmdt

tha

Chemical Conant-10h

Sound and munchmdt 815m“
Lawn, ﬂuent-1

83:.

-

Door Duo:

ago. “cording tho cm»
dumumof om maths
and
mime mutation Dina
ehlowmino, we hm
with
our
no man
thou m
imotiuttm
mum
on «trying out o numb» of trial; of Dunn and

venturing out

wanted.
promo“. hm hm

Mismatch. as

Ditta

and

W

pramino

you

given in

oubjoeta.
(inEEG

with
loborotory.

than of the aluminum hams am in tho

ad

omntooo investigating hf pitta
thom lobarotary.

Tho

findings in both

with two!” in
'

doom

ad chlorpmim.

quito similar with tho
moltotod.
1'9 obtain o

Wt
utio
mu for

«shinning:

mumma! mi...

botns

ultra ad chlomrmatno
maximal:
ad panama 1t 1:
1.24. Actually. an. Gonhm. an ad Manor hm roportod
that amino and ehlorpmtno has a .m:.: otfoct in a
of thou mausm. TEA and yumm—
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TEA
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to

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blocking taunts,
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app“: to

with

or. tho mount um. tho records are
dual
amzmu and W. m onlmthla tam. if any of thou
of intern“ to
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going into

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on

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hath

this

wk. ad Tara

taproeood
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you noon otter
mm. Wot

will?»

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labor. day.

Out

but «and. for: plmat tmér.
Shandy you",

mljb

It“
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Mu Fink. mm.

‘

at: Dr.

&gt;

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Director

�</text>
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                    <text>June 3,

19 88

V. N.

Bagadia, M.D.
Broadway Building, 2nd Floor
Matunga
Bombay #00 019
India
Dear Professor Bagadia,
Yes, I believe that our readership would be very interested in a survey of
the use of ECT in India. There is a dearth of good data on ECT usage, and much
argument, whether usage is increasing or decreasing, whether the indications are
changing, and whether consideration is being given to the effects of electrode
placements, current type, dosage, frequency of seizures, seizure durations
monitoring, and other technical details. I enclose a copyright release which should
be signed to accompany the article.
The article "Reevaluation of ECT ~6: Right Tempemparietal vs Bitemporal
Electrode Placement in Schizophrenia", is scheduled to appear in the third issue of
CONVULSIVE THERAPY, in September this year.
I

look forward to hearing from you. My best regards.
Sincerely yours,

Max Fink, M.D.
Editor

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                    <text>May

2, l968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

100 York
New

Street

Haven, Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new psychotropic drugs in the treatment 0f the mentally ill. Our
initial results have been encouraging and we would like to expand
these studies since they provide opportunities to test hypotheses
which may not be practicable in the United States. For example.
we have Just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.
such a program would include
Director
of
the Division of Psychopharmacology.
Itil,
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan, Chairman of the Department of Neuroosychiatry, University of
The

principal investigators in

Professor Turan

M.

Istanbul.

Thank you

for your interest.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>May

2, 1968

Dr. James Bailey

Foundations Fund for Research

in Psychiatry

Street

lDO York
New

Haven. Connecticut

Dear Dr. Bailey:
During the past two years I have participated in a collaborative
study program with the University of Istanbul in the evaluation of
new

psychotropic drugs in the treatment of the mentally

initial results

have been encouraging and we would

these studies since they provide opportunities to

ill.

like to

test

Our

expand

hypotheses

which may not be practicable in the United States. For example,
we have just completed a high dose and very high dose fluphenazine
study, to test the recommendations of some French scientists.

In discussing our program with Dr. Jonathan 0. Cole, formerly
of the Psychopharmacology Research Branch of NIMH, he suggested
that I write to you to inquire whether the Foundations Fund might
consider an application on behalf of such a study program.

principal investigators in

such a program would include
Director of the Division of Psychopharmacology.
Missouri Institute of Psychiatry (St. Louis) and Professor Necmettin
Polvan,]Chairman of the Department of Neuropsychiatry, University of
The

Professor Turan
stanbu

M.

Itil,

.

Thank you

for your interest.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>Jmo

11', 1965

Percival Bailey, M.D.
Division Director

State of Illinois

Department of Mental Health
Division of Resend-u Servioes
1801 West Taylor

Gringo, Illinois

Street

60612

Dear Ilr. Bailey:

mm for your letter of June 10, describing
to find a replacemnt.
I came to St. Louis in 1962 at the newest of Dr. George
Ulett to establish a research prom
and
similar to
the Illinois Psychiatric Institu . It wasinstitute
our intention to
affiliate dimly with the Departmt of Psychiatry of Washington
mimity. For a variety of masons, that affiliation did not
materialize. The Missouri Institute
of Psychiatry, however, has
been established and is an operating research
facili .
Thank you Very

your wish

intemt is in resend:
we) smewhat less in
aminietmtim. Duringnthiaprogram
three
period I have had
year
the opportmity to participate
the training prom at
Washingtm University and find that this interests me
very ouch.
‘me image that I have of my
and future roles is more of
pmsmt
a participant in an academic pmgm, mo continued direct partici~
pation in research
My

research

.

om

projects.

If the position of Division Director
in its operation,
provide for the oonommt appointment to may,
an active Deparonent of
Psychiatry, and if the direct participation in research program
is midemd an essmtial part of this position, than I would be
interested in discussing this further.
'

-

Sincerely yours ,

Fink. H.D.
Professor of Psychiatry

Max

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                    <text>relax-nary 25 1980
,
Dr. Samuel Bailine and
Dr. John Reu

Department of psychiatry
Long

Island Jewish-Hillside Hospital

Glen Oaks,

New

York 1100a

Deer Dre. Bailine end Ran,

to attend your presentation on February 13. The
topic is of interest to me. in large part because of my experience at
Hillside with ECT and insulin come in the 1950's. I am writing to
request a copy of your report, when it is available.
I

was unable

Thank you

for your cooperation.
,Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Septenber

15 , 1965

Mrs. Bainbﬁdge

Secretary to Dr. 1311 Robins
Department of Psychiatry
Washington University School of Medicine
St . Louis, Hissmri

mar Hm. Bainbridge:
While I will be attending the departmental matings
regularly, I would prefer to bring my lunch with rm and
would mquest that you do not ordar sandwiches on m behalf.
Last year, to mandate my teaching assigunent, I
received a tenpomry parking permit from the Barnes Hospital .
Is it possible to massive such a parking permit once again
for this limited use?
ﬂunk you for your ao—opemtim.
Sincerely yours ,
Max

Fink,

PM).

Professor of Psyduiatry

HF:kp

�</text>
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                    <text>November- 28, 1965

Baird-Ram Printing
0. Box 539

I”.

Nashville, Tennessee
Gentlomn:

Co.

, Inc.

37202

We

Enclosed is a
0m” for two-hundred mprﬁnts
for the article "Sociopsychological Aspects of Psychiatric
’I'rottmnt - A Rupert of Tantalum in mm Voluntary Hospitals"
mic}: is the official order from the University for the reprints

mquestod

may.

Sincerely yours ,
Pink, H.Du
m
Professor of Psychiatry
HF:kp

�</text>
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                    <text>New 28,

1965

Printing Co. . Inc.
Ward
539
P. 0.
Ben:

mm)... Wage

37202

Guam:

WhaWMrfwtwa—hwmdnpdnts
WtwAmmofwmmmVolmmfbspﬂm”

for the article ”Souiwdxological Asp-eta of Psydﬂatric
which 5.8 the official carder from the University for the “prints
ﬂuently.

mud

Shandy you“.
Hut Pink. NJ).

Professor of Psychiatry

.

w-

w—wv—

.w-

�</text>
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                    <text>Juno 3. 1964

Dr. G. H. Boird
‘91. Cyprus Rood

mpporley v.21:
ﬁottinghom,
England

..,,,,_A

Door Drg Baird:
“wwumaw,”

for you: inquiry. The Missouri Instituto of
Psychiatry in the research_and training center of the Division of
Ecntol Diacncos of Missouri. It was established in October, 1962,
with laboratory and clinical facilitico for rcscarch. At the
otcocnt timc. of 150 beds, we are utilizing 70 for research pur~
poses. Laboratories are establiohod in pharmacology. psychology,
and electrooncophalography, as well or a computer center for both
statistical Inc EEG analyses. There in a specialiscd psychiatric
library as a component port of the Institute. Animal facilities
are now being built.
Thank you very much

ww-

m“v)‘—r-\y':-"q

.

,

h'nm'o’m

In addition, there is a fully qualified throo—ycar psychiatric

rooidoncy training program at tho Institute, and a spacial train~
ing program in clinical psychology is being established. Both in
tho rnaoorch programs and in the training programs, the Institute
is affiliated with tho Dopartnnnt of Psychiatry of Washington
ﬁnivoroity School of Medicine.
At tho protect time, there :30 a combo: of research programs in
progress. These include Lithium as a therapy for mania; the use
of Yohiubinc as n procipitnnt of anxioty and the devolopoont of
antiwnaxioty agonto; relation of EEG patterns and organic factors
in tho trontonnt of therapy resistant poychotico; computer analysis
of the cloctronnccphnlogrcu; tho oﬁfccto of drug withdrawnl on
behavior in tho chronically ill; and tho treatment of psychotic: by

nurse relationship therapy.

position so Roccnrch Sciontiot will be available an of October 1,
in tho prosrnn‘with Dr. Somocl Gershon, who has an active program
in determining the ofiocto of new compounds on blocking agents to
the Ditrnn induced psychosis. For the past year, he has boon oxplorlng, both in animals and in man, various agents in terms of

A

�Dr. G.

M.

6-3—64
Page Too

Baird

their blocking the psychosis or diatoibed behavior following Ditron.

Recording: are made of various phyaiologicnl variables. behavior,
and the EEG.

A

Appointments are made at an initial salary of $12,000, with adjustnento as may be warranted for reaearch experience and qualifications.

available for rental or for sale within ten minutes
of the institution. while transportation costs to America cannot be
paid directly, it has been the established policy of the institution
to increase the salary by $1,000 in lieu of a direct payment for trens«
portntion. This has the advantage for candidates who remain with the
Institute of providing a higher base celery in subsequent yeare.

Accommodations are

Appointments to this Institute require the satisfactory completion of
the E.C.P.M.G. examination. I on taking the liberty of enclosing a
brochure describing that examination and would recommend that if you
consider coming to the United States. that you undertake this examination as soon as practicable.

I will be in England during the last week in August and can arrange to
meet with you at that time to discuss this appointment further.
Sincerely yours,
Fink,
Director

Max

KF/jh
BBC.

M, D.

�</text>
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                    <text>Jana 18, 1964

Dr. G. M. Baird
91, Cyprus Road
Happerley Park
ﬁbttinghsm,
England
Dear Dr. Baird:

for your letter at June
I have read with interest.

Thank you

which

14, and the unclosad

ruport,

310:: and myself will be in London on August 27 and 29,
in Newcastle-onwlyna on August 28, and in Birmingham from August
30 to Snpttmbe: 3. Wk would appreciate an opportunity to meet
with you at tuna tin: during that period. If_you would indicate
which city you would ptufer, we can maka more detailed atrange~
aunts as to exact time and place in future correspondunca.
Both Dr.

‘

We

shall

be looking forward to wasting you.

Sincerely yours.
Max

Fink, H. D.

Director

m/Jb

�</text>
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                    <text>‘

m»

December 4, 1979
Mb.

Hertha Baird

University Hospital

Stony Brook, ﬂew York

Dear Ms. Baird,

Re: Dr. Sherman

Kieffer

I hate known Dr. Kdeffer since 1972, as a fellow Professor in
the Department of Psychiatry and Behavioral Science at SUNY at
Stony Brook. In that time, I have worked closely with him in
Departmental matters and have come to know his skill as administrator,
clinician, and teacher.
Dr. Koifﬁer has an extensive experience In the U.S.
Public Health Service, and his knowledge has been most useful in the
development of programs in drug therapy. He is a kind and gentle
man, with infinite patience, tolerance, and reliability. Hie
expertise is in the study and management of drug abusers and in
this regard, he is one of our nation's ﬁeaders.

I

am pleased to recommend him for appointment to the
of University Hospital.
service
Psychiatry
:v.

:,

Py-w-vw‘u

Sincerely yours,

«ﬂy-32:"

wwmmW—rMa—vn-w

"W

'
=-=

ELY!

m

rmL-m

‘rvggw;

a”

wawvsvmvrw-wbw

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 4, 1979
Ms. Hertha Baird

University Hospital
Stony Brook, N‘Y'

Ref: Leon Hankoff, M.D.

Dear Ms. Baird,

I am pleased to write the following on behalf of the
application of Dr. Leon Hsnkoff for privileges at University
Hospital. I have known of his work in psychopyarmecology for more than
two decades, and have come to work with him in the Department at
SUNY at Stony Brook during the past two years, both in the invitation
and planning phase and in his present position as clinical director this
year.

Dr. Hankoff is a skilled researcher in psychophermacology
and in clinical sciences. He has written a fine treatise on suicide,
which has lately received excellent reviews. In the past year, he
has developed the clinical programs at University Hospital and in

this regard, he has impressed me with his patience, clarity of'
purpose, administrative and clinical skills, and reliability. He
is a skilled teacher of medical students and residents; and he has
organized a fine clinical staff which should do a credible job in
the development of the Psychiatry Service at University Hospital.

I am pleased to racemmend him for appointment to the
Psychiatry Service of University Hospital.
Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>January 21, 1963

8183 Susan V. Baku»
Cauncil Committea on

Public Knalth and Bducatian
thical Society of The state of
756

third

ﬂew Ybrk

Avenun

17,

New Ybrk

New Ybrk

Dear Miss Dakar:
Thank yau far year invitatian to speak hafhre tbs
Sullivan Cuunty Radical sociaty. I wanid bu pleased
tn do this but have recently unvaa to 3%, Louis. It
stems impractical frat this lunatian.

31ncernly yaura,
HISﬁOURX IKSTITUTE GP PSYRKIAIRY

Max

Fink,

Biraetar

erjr

Man.

�</text>
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                  <elementText elementTextId="101314">
                    <text>Fobruaty 19. 1964
Dr. Alvin B. Balaban
19 Eiége Drive. East
Great Neck, L.I., Raw York
Dear A1:

issue of ab. ﬁewsletter brings with it 3uochar vtaw of
the Society's gtuwth and devalopment. Hartha and I read
these avidly. as they represent a contact with our past.

Each

It

has been two yetra since I accepted the responsibility to
develop the laboratorias in St. Louis, and I have recancly
writtan a summary of this. I am enclosing a copy for your

information and

if it is

of any help to

may abstract what you would

written here.

like.

Thu

my many

story

13

friends,
lnrgely

you

For ch. pas: fav noncha, tbs adminintrattvo demands buvo
bacon. incranltngly lat: as my asaociataﬁ have ucceptcd
various of tha burdcusc This has given an an Oppertunity to
return to the laboratory and I have haen able to undattakc a
number of studies mysali. The computer analysis of tha EEG,

and the psychopathologtcal atlousmant of the severe mnntally
111

are both undo:

my

ditcct auporvision.

uh: good work with the Kewalctter. Martha join:
in landing our regards and but: wishes to Batbara and to
our friends in Great Neck.

Keep up

Sinaaroly years,
Max

tint.

Director
NP/Jh

he.

M.D.

me

all

�</text>
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December 23, 1984
Ross Baldessarini, M.D.
Mailman Laboratories
McLean Hospital
115 Mill

Street

Belmont, Massachusetts 02178
Dear Ross,
Thank you very much for your prompt reply to my request for more
information about your DST reviews. The reports are very useful, and I will send
you a copy of my review for Peter Loosen when it is done in January.
When Yannis Papakostas worked at Stony Brook and reported that failure
of the DST to normalize was associated with a poor clinical outcome, 1 was

diffident, but encouraged him to publish his finding. Since then, the number of
reports has increased, and while the diagnostic usefulness of the DST remains in
question, i am more than ever impressed that the continued presence of abnormal
cortisol measures is a poor prognostic sign -- one that we ignore rarely, often
increasing our treatment, or at the least, increasing our vigilance of the patient's
course. Your reports support this impression.

Your summaries combine the data for antidepressant drugs and ECT. The
efficacy of ECT and drug therapies differ, often markedly, with ECT usually
superior to that of drug therapies. It may be a fruitful exercise to extract the ECT
data from the other antidepressant therapies, to assess the relationships between
DST findings and the ECT process.
As you may know, i have accepted the responsibility to edit a new journal,
CONVULSIVE THERAPY, to be published by Raven Press, with the first issue to
appear in March. Should you undertake such a study, I would be pleased to have an
opportunity to consider it for this new journal.
My

best wishes for a happy and productive 1985.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

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                    <text>n.

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December 14, 1987
Ross Baldessarini, M.D.
Mailman Research Center
McLean Hospital

il5 Mill Street

Belmont, MA 02178
Dear Ross,
The letter by Lieber in the American Journal of Psychiatry seems to have
been a spontaneous letter, not submitted in response to an article in the Journal. It
looks like an old-fashioned testimonial. For my part, it argues for a complex
polypharmacy whose worth is not known but whose risks are formidable.
i have written to Morry Lipton as

attached; and am sending you a copy as
one of the two established psychopharmacologistson the Editorial Board. Should
the Journal not publish a disclaimer noting that the recommended methodology is
not substantiated either by published studies or established practice?
in the past few years, i have been asked by lawyers to review the records
of patients treated by polypharmacy;patients who have had significant damage

(including two cases of death) which could be ascribed to such practice. One well
established practitioner gave up his practice when faced with charges of abuse of
practice largely due to polypharmacy. Should we not respond to the Lieber letter?
My

best regards.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

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                    <text>Fcbruary 2‘, 1965

Hr. William 3. Ball

Associate Protaacor of Ensinaaring Analyais
School of Enginaaring
Washington Univcraity
St. Louis, Miasooriv 63130
Daar Hr.

Ball:

1 an plaaaad
Mr. Richard A.

to rcapond to your latter of inquiry regarding

Mahler.

In 1962. whan I was invited to aatabliah tha Hiatonri Institute
of raychiatry an a raocarch and training cantor for tho Division of
Hontal Disaasas. I had bacon: acquainted with the potentialities of
computer applications for the kinds of roscnrch that the Director
of tha Division and l wiahad to support. I approachad Hr. Dannkochlcr
for aaaintanca. and in the ensuing nontha found his to bc most hclptnl
in clarifying tho projecta and programs which could be established
horn, in raconaanding the configuration of computer cqnipnant which
would ha halpfnl. and in racoaaanding parronncl to participate and
catabliah thia unit. Hia advica and anpport havn boon fundamental
to tho auccaoa of thia unit. At all tinca. I found his ondaratanding
of the problcna which I praaantcd (including hit grasp of anhjccta
aa alactrocncaphalography. which warn novcl to his aapariancc).
During the initial yaar. I raqnnstad his halp in tho praparation of
new digital conputcr prograna. Ho dovotcd much of his own tilo to
helping oa. and praparnd coma programs for up forncr associata in
How

York as

wall.

In addition to up internata in dirnct applications to
psychiatric raaoarch, l waa internatad in the problems of information
rottioval. I found Mr. Daankoahlar vary knowledgaabla and his
advico and raconncndationa in this area worn. and havo continued
to ha. moat cogent and ralavant.
.

In addition to aatahliahing our cantor, I have always found
no with tho clarifications l
naadcd in nndaratandina programs, raporta. and in providing ma
with tha opportunity to work with him or his aaaociatco, including
making tha 7072 fracly available. I found his caplnnationa of problems
him

fully nonparativn in providing

�page 2

straightforw;rd and altar. Eating the first your, I audited one
of th: basic Porttan programming classes which he held. Rio lac~
turns warn ptupamod and his explanation: ware oxcnll-nt.

this cxporiencc. I consider it an honor and a
ploasura to rueonmnnd him for Ippalntmnnc an a teacher in Computcr
5c1¢n¢os. My oxpcrlanecs and all tha connuntn I have heard
aervu only to onhanec Hr. Damukochlot’s cxcallcnt tuputatton and
his association: with this center.
Bnnod on

Slnccrnly yours.
Mt: Pink. M.D.

Err):

Professor of Payehlntry

�</text>
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                    <text>3'

.
.ﬂmuMw-

“-3,,“

-.

I}

May

Dr. Robert W. Ballard
Medical Director
McNeil Laboratories,
Carp Hill Road

a,

1968

Inc.

Port Washington, Permsylvania 1903“

DearDr. Ballard:
At a meant meeting of the Pomulary Oaunittae of Metropolitan
Hospital on the recamBndaticn of the Claiman of the Department
of Psychiatry and the Clair-nun of the Psychophannacology Study Gimp,
Haldol (haloperidol) was placed on the Fomnlary of the Howital

for six nmths trial.

Wehaverecormendsd itsusetommmsidentsanditwwld
if supplies could be made available for their
use through the pharmacy of Metropolitan Hospital. Mrs. Quzado
is the chief pharmacist.
be very helpful

Would it be possible for you to arrange to have an adequate
clinical supply made available to the pharmacy?
Many

thanks.
Sincerely yams,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>December 4, 1991

James Ballenger, M.D.

Chairman, Department of Psychiatry
Medical University of South Carolina
171 Ashley Avenue
Charleston, SC 29425-0742
Dear Jim,

great pleasure that | submit this letter in support of the
promotion of Charles H. Kellner, MD. to the rank of Professor of Psychiatry.
It

is with

have known Charlie since about 1985 when he moved to South
Carolina and asked for my advice in training in ECT. Since then, he has been an
active reviewer for Convulsive Therapy and an occasional contributor. have
followed his research publications and listened to his presentations at scientific
societies. encouraged his acceptance of an active role in the Association for
Convulsive Therapy, as well as the course in ECT which he is chairing in
Charleston in February, 1992.
l

l

l

Charlie is a well trained psychiatrist, certified by the American Boards
with special certification in geriatric psychiatry, and eligible for certification in
neurology. His teaching and administrative skills are defined by his roles in
residency training, ECT, and consultation/liaison.
He is an active researcher. In his period at NIMH, he reported useful
findings brain imaging (CT and MRI) in relation to measures of cognitive
impairment, hypercortisolemia, and lately in patients with obsessive compulsive
disorder. He has published numerous letters and commentaries in ECT, and
has a series of contributions in ECT accepted for the 1992 APA and ACT
in

meetings.

He is an enthusiastic clinician. While I have not had the opportunity to
observe his clinical work directly, have read numerous clinical research
contributions and these exhibit enthusiasm, interest, and breadth.
I

At this time, he is one of a handful of ’young’ researchers in ECT in
the US. Considering the general antipathy to ECT among psychiatrists, his
willingness to use, teach, and study ECT is remarkable. A few months ago,
was asked by Bob Cloninger for recommendations for a young researcher in
ECT for his Department in St. Louis. gave him three names, with Charlie’s at
the head of the list.
I

I

�Re: Charles Kellner, MD.

Page 2

His contributions to Convulsive Therapy have been intelligent and
enthusiastic. In recommending new appointments to the Editorial Board for
1992-1996, Charlie was unanimously invited.
like his calm and quiet ways, and his enthusiasm and willingnes to
admire his academic skills; recommend him for promotion without
reservation, in the full expectation that he will continue to contribute to the
academic vigor of our field.
I

work;

I

I

Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>7388-80138
30 ﬂovamber 1973

Iver P. Stall,

M.D.

Departmnnt of Psychiatry

University of Indiana
School of ﬂcdicine
1315 “out 10 Street
Indianapolis, Indiana 66207
Daar twat:

In talking to Jaye. I indicated that I had not received
corrected
your
gallay. I havc corractod the duplicate and I
am sending you a Xeroxad copy which permits you to check the
corrections which I an suggontina. I would be grateful if you
would glance at chase pagan and crop an n.11ne an to whether
the suggestions are similar to chose mods by yourself, as wall
as any addttional counonts.
my

best regards,
sincarely yours,
Max

Fink. H.D.

yrofoesor of Psychiatry

HF/cia
Encl.

�</text>
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                    <text>July
Dr. Joseph C. Banford, Jr.
Dean
New York Medical College
Flower and Fifth Avenue HOSpital
Fifth Avenue at 106th Street
New York, New York 10029

18 , 1967

Assistant

.

.

Dear Dr. Bamford:

I regret that I am scheduled to attend an international
colloquium on December 12 , and would ask that the lecture be

mated up to one
or December 5.

of the other dates for psychiatry -

November 16

Thank you.

Sincerely

yonms ,

Fink, M.D.
Professor of Psychiatry

Max

\
-

4M;:u€-r"

�</text>
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'

Dr. T. A. Ban
Douglas Hospital
6875 LaSalle Blvd.
Verdun, Quebec
Canada

Dear Dr. Ban:

I

that you have canpleted a pmlimirm'y
in
the
of depression. You know
of
cyclazocine
survey
we am particulwly interested in this application, and I an
have recently heard

Want

writingtoask foracowofyom‘pmliminaxympwt,vmenthatmy
beoane available.
Many

thanks and

my

best-regards.
Sincerely yams ,

cu...

ma,“

_

,_.

Fwy—VF-

Max
WWWVv.Ww-.—W.

w:

m

Fink,

M.D.

Professw of Psychiatry
MF:kp

�</text>
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‘m—y awn-WV

“w“ Wuv'r "Harv-"Wt"‘X!"X“val1'-‘II)U‘&lt;I ‘wW'P—x"‘w-......,.—.._..A .4- mm.

,.

“7....

”-7

February 21, 1975

Thomas Ban, M. D.

Division of Psychopharmacology
McGill

University,

Room

131

Research &amp; Training Building
1033— Pine What

Montreal, Québec
Chnada

Dear Tom:

.

Wm

1m,

.

Thank you for the copy of "Depression and the Tricyclic
Antidepressants" which you so kindly sent me. It is a good summary
of the uniqno views of the Canadian~8wiss schools of psychiatry,
and I commend you on a clear presentation.

Sincerely yours,

ﬁ.—w&lt;~»mr

awry—”NVV‘VMVN.

Fink, M. D.
Professor of Psychiatry

Max
,
,,.
_
A

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�</text>
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7m:

WW

June 7, 1978

mmuﬁm,mm

Department of Psychiatry

Vanderbilt University
Nashville, Tennessee
Dear Tom,

Thank you for the copy of the Psychopharmacolqu of
Thiothixene, which arrived today. I had some time to go through
it and it seems like a complete review of the pharmacology of
this interesting compound. I am sure that it will be distributed
widely and should do much to help in the assessment of this

compound.

My

regards.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

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Dr. Thomas A. Ban

Douglas Hospital
6875 LaSalle Boulevard
Verdun, Quebec
Canada

Dear Dr. Ban:
Thank you very much for your notification that I have
been elected a founding member of the C.I.N.S. The notice

of October/November 1965 indicates that a draft of the
constitution will be attached. I have not received such a
draft and would request a copy if one is still available.
Sincmely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>August 24, 1964

Dr. M. Bandyopadhyay
87, Debinibas Road
Calcutta 28, India
Dear Dr. Bandyopudhyay:
wish to thank you for your
interest in our institute.

we

letter of

August 3, and your

Appointment to the Institute requires the satisfactory completion of the E.C.P.M.G. examination with either a temporary
or permanent certificate. We would be pleased to hour from
you further utter your completion of this examination when
you have the certificate available. we are enclosing a
brochure which you may find of help in making application for

this examination.

Thank you again, and we

shall await your re-epplicetion.
Sincerely yours,
Mex

Fink,

Director

IJb
Knee

M.D.

�</text>
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                    <text>an

MVP

T0:

Mr. Thomas Bannon

FROM:

Max

As we

Fink,

October 9, 1970

M.D.

discussed, the enciosed

PD-4 forms

refiect salary

adjustments for research assistants of various types, occasioned
by the equivaience of their duties and quaiifications with union

personnel.

we

will

I

fear that if we fail to make some adjustments,
larger saiary demands in a short time.

be faced by

Piease advise.
Many

kt

thanks.

�</text>
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                    <text>y .~

,_..

7

rmu—rmm.

as- "w:»m__s.mﬂw.ra—-Wrmmrww-«we-mm

-.-—~—w---.—&lt; .—

July 8,

‘

~-

-.

-wm—mwn.-.mw

-—.,—w "a. -.—-r-.—rvw—Wm..........____,.,r.._...,_,_“W...

_,__

Mwﬂum

1968

Dr. Jack D. Barchas

Asst. Professor of Psychiatry
Stanford University School of Medicine
Stanford Medical Center
Palo Alto, California 94304
Dear Dr. Barchas:

is

It

Membership in the American Psychopathological Association
of members and election at an annual meeting.
is the custom of the membership committee to ask members for

by nomination

their recommendations in the fall of each year.

Earlier editions of the monographs published by the Association
contained lists of members. If you would check this and request
a member to submit a nomination this might be useful to the

membership committee.

Sincerely yours,
Max

Fink, M.D.

Secretary

Mszp

�</text>
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                    <text>May

Riezen,

Honk van

Scientific

30, lQTh

D.

M.

Development Group

H.V Organon
Oso , Holland

Dear Bank:

First, let

me

apologize for not having reported earlier;

two weeka ago, I was concerned that my
impressions may have been in error, and knowing that she would be

but, after visiting Joyce
at the

her.

meetings. I waited to confirm.my observations with
Following are some notes concerning our projects.
ECDEU

chewed me

is directly involved with these studies.‘ Their optia
in studies of OI~63 was in marked contrast to their pessimism

Milstein

mism

with

1. Jozpe Small. I visited Indianapolis on may 7. Joyce
through the laboratories and we were accompanied by Victor

who

GB~9h.

They have completed nine subjects in
the series, and in no instance have they been able to avoid ECT.
While none of the patients exhibited a clinical.woraening, none im»
proved sufficiently to provide any feeling of optimism. When I enquired about side effects, she called her nurse—monitor who seemed
comforteble with the drug and unable to identify symptoms that were
problems to the patients. There were no "anticholincrgie" symptoms.
But Joyce's questions were sharp and her statements stronger than
the date seemed to warrant. I become concerned that we may be
seeing the development of e halo effect, i.e., the failure of the
first few patienta to improve markedly has set the etege for a
negative evaluation. She asked me whether she could discontinue
the study after ten subjects without 'breaking her worn’ to you.
(In discuseing this in Florida, she was more negative than the date
considering the very severe test to'which the drug was
warranted,
put .

a.

‘-

I'

wwwmm.w«nnnz

'v’.

s
‘2.

m

rang:

I]

r

03—

h:

�Hank van Riezen

May

—2—

30, 197h

I suggested she complete ten subjects, summarize
her observations, send the reports to you (me), and not induct
any new patients into this study until these data have been
digested.

b. OI~6§: This study is progressing well. Enclosed
sheet
data
summarizing her observations in nine subjects to the
is a
end of April. She finds 01-63 to have little effect in the immediate post-seizure recall period, but may improve recall at twenty—
four hours. She is anxious to go to the next groupof subjects, in
the same design, but at the higher dosage of 30 mg. I found this
suggestion reasonable, and encouraged her to proceed.
She and Dr. Milstein indicated that they were also
re-assessing the memory tests and they seemed pleased that some of
the methods they have developed had shown differences in OI~63
effects. Some additional tasks are being tested at the same time

as these studies are in progress.

Both she and Dr. Milstein were somewhat depressed,
however, about their local funding and space problems, reporting
that some of their grantgs had not been approved, and that she was

anxious to-obtain additional industry support for studies.

Joyce has collected tapes of EEG data with 01-63 and
is a unique 8—channel, l/h inch, General
Precision instrument which is no longer made. _Failing to find one
in New York, I decided to send a member of my staff (Peter Irwin)
GB-Qh.

Her tape recorder

with one of my h—channel recorders to Indianapolis to transcribe the
data from her tapes to mine; and we will then analyse the data here
(unless you prefer to use these tapes to test your system in 035?).
;I have set a date for June lB-lh for the transcription.

,,
w.

..

1-,_.-.,

am

.v:.

“View”:

‘qzvrr-rzn

)

-—-:

rm-zwsaﬁr'nn

Lyman-or

.1

14"‘A—W1n-mvimnjwy‘”

I

have had

(Joyce gave

a

little visitor's

and send them

to

packet of her programs;
for your.information.)

you

the presenwell received.
'(Please edit it
of the report is
and I would be grateful for any corrections of fact or-nuance that
you may suggest.) The diacussion was started by Joyce, who reported that she completed nine subjects in the ECT paradigm; that
there was improved recall of learned material twentybfour hours
2.

ECDEU:
The meeting was well attended,
ACTH Peptides on Memory and Brain
A copy
enclosed.

l,tation "Effects of
5

me

these copied

and

Function" was

�Hank van Riezen

«3~

May

30, l97h

after the seizure;

and that the effects were not evident in the
immediate post—seizure recall. She was encouraged by the find~
ings, and said she was extending the sample at a higher dose of
30 mg. Others enquired about the similarity of 01—63 to UCB

(prracetam) and to Unger's

compound

availability of the materials.

(scotophobin), and to the

timely because the next afternoon was
in depression and schizophrenia. The
N
data was sparse, with the usual of four to ten in each study.
Hoeehst was well represented (six visitors) and Dr. Alan Gordon
summarized the findings of European studies as equivocal or nega—
tive in depression. He reported sleep EEG studies, which failed
to show an effect of TRF. Drs. Prange, Lipton, Hollister and
Huey individually reported small studies without consistent findings in depressed and schizophrenic patients. Yet, each reporter
apologized for the paucity of the results; described some anecdotal,
single cases that were remarkable; and suggested that some findings
were there, although they did not know how to extract them. Itil
presented EEG and the clinical data from Turkey, and his report
was optimistic and constructive. He reported well defined EEG
changes, similar to dextroamphetamine, with clinical effects in
depressed patients of short duration, with self reports more
positive than observer ratings. There was some criticism of his
report, notably the question by Gordon that since he could not
find EEG effects of TRF in the sleep record, how did Itil explain
his findings in the alert subject. This gave Itil an opportunity
to describe the differences in methodology, the problems with
sleep assays, and the necessity for quantitative methods.
The

presentation

devoted to reports of

was

TRF (TRH)

I was left with the impression, both by the interest of
the reporters and the audience, that the peptides were now among
us, and that much study will have to be done in the next few years
defining their activity and developing new methods of analysis. A
few investigators (N. Kline. D.F. Klein, J. Simeon, L. Hollister,
R. Shader) asked about the report and 01—63, and I will send
copies of the report to them, hoping that their interest has been
aroused.
I am sending a copy of the report to the editor of
Psychopharmacology Bulletin for her consideration for inclusion
in a ferthcoming issue.

�~h—~

Henk van Riesen

May

30. 197k

3. FDA Report and Dr. Ksstin: I have decided to send
the report I have given to the ECDEU, as well as a covering letter describing the date of the Miller and the Fink studies.
I will omit reference to the recent Kastin end Sandman reports.
Abba sent me the latest report with a covering letter that seemed
unnecessarily harsh. However, I am willing to serve in the re—
lationship with him being acutely aware of his idiosyncratic and
irritating behavior, but accepting these as necessary accompani—
ments of the program.

the

FDA

In reading Ksstin's letter to you of April 29, I found
references to a study of ? OI—63 in schizophrenic patients. I
have not heard from Kastin regarding this study. Should he wish
to file an amendment again, and to avoid the criticism that we
‘are holding him up, I am writing to him directly (enclosed).

I

Because

h.

Essman:

I read the

Essman

letter

and the two

scales.

these confusing, I called hhn,snd he explained
found
He
derived from some studies by

that the tasks were

Squire.

'esserted that the tests have had some reliability testing (two
forms) and at least two applications. It should be interesting
and if they are sensitive to memory loss
(recent and remote), then thetpplication of the tests may be

to read these reports

useful
in the

5. Klein2 D. F.: we met in Florida (although we live
some community, I tend to see him in fer-away places) and

He wished to read the reports which
basis of my peptide summary, and I gave him a duplicate
set that I had with me. I shall send him a copy of the ECDEU
report and try to meet with him in Great Neck in the next two

began a discussion of OI~63.

were the

weeks.

I

have received a

letter

from Jack regarding

the visit

U. S. for a review of the date analyses of GB~9h, and I
have made arrangements for Drs. Boneto and Guy of the Biometric

to the

Laboratory in Washington

to assist us.

I have become even more interested in the peptides since
the
summary, and I look forward to listening at Utrecht in
writing
my

best regards.
Sincerely yours,
Man

MF:ed

'Enclosures

Fink,_M. D.

Professor of Psychiatry
,

�</text>
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                    <text>av-u. w.-

rﬁww—vlwir"

v-mq-

..».-.p»wv—W'

~

-:v

'v-I:

W'xY'wvvr.7\I-m
‘Wmvrﬁwsv‘r'w-W‘vumaa-I;

-.-

,.., u- c-‘vrs'v—. —-

“.w-I—e—yn

mm

my.

7"".

February 18, 1978
William R. Barclay, H.D.

Editor,

JAIA
535 North Dearborn

Chicago,

Illinois

Street

60610

Dear Dr. Barclay,

I have just read the February 6 and 13 issues of the
writing to suggest that the senior editor, Dr.
Z. Danilevicius, has done the readers a disservice in his selection
of abstracts from the American Journal of Psychiatry (pg. 657, February

Journal,

and I an

13, 1978).

In 1976, the American Psychiatric Association held a
symposium on electroconvulsive therapy and invited an outspoken and
brash critic, Dr. J. Friedherg to tpreeent a report. His report was
shown to be dated and biased (see critique by Fred Frankel, Amer. J.
Psychiat. laulelu-lOlQ, 1977). Indeed, the Editor of the American
Journal of Psychiatry, Dr. F. Braceland initially rejected the article

as unfit for publication. but agreed to publish the article in the
context of the symposium. Yet, he added a disclaineu that the articles
had not received the usual criticism.

It is unfortunate the the readers of the JANA will read only
the abstract of this biased and prejudiced report, without recognition
of the critique of Dr. Frankel or the comments from the other reports.
It was of some interest the same evening to read Dr. D.X. Freedman's
review of the interesting issues of the immediate past and to see that
he considered EC? to have some merit and that he cited the report by
Dr. Frankel. (see JANA, 2/6/78. pg 510).
1
va.

,-

mcwml-wu-

m-

It

seems

that

you may wish

his bias and selection criteria.
citation of the literature.

on

to challenge your senior editor

The

readership deserves a better
Sincerely yours,

NWWW

Imus—arm

.
.awv§-§'_,V'

u.
A
m

Hex Fink, M.D.
Professor of Psychiatry

,n-

:wn'rw' H.

.mm &gt;Vuv'-’ .~—

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                    <text>January
Mr.

Gilbert

M.

ll,

1968

Barcus

Mcﬂeil Laboratories Inc.
33l0 Nostrand Ave.

Brooklyn,

New

York

Dear Mr. Barons:
I regret that your failure to call my office for the opportunity
to present your questions may have led to some confusion. You must
know that a consultation in the hall is highly inappropriate.

If I understand your question, it was whether we were willing
to undertake a clinical study of haloperidol or any other procedure
which would make this drug available for clinical use.
Please be advised that for the past year the Department of
Psychiatry has had an established committee to review recommendations
for new drugs for clinical use. This committee, the Psychopharmacology
Study Group, meets at irregular intervals at the request of the Chairman
to review the available data prior to making recommendations to the
Formulary Committee of the Medical Board of Metropolitan Hospital.
If

McNeil

Laboratories is interested in having haloperidol

would suggest that you write a letter to me and submit
six copies of any information you wish to bring before the committee.
I will be pleased to have the committee review this recommendation at

reviewed,

its

I

next meeting.

~

Incidentally. the administration of compounds not accepted in
the formulary by members of the staff is governed by the
ulotions
regarding research in humans. To comply with those regulat cos it
would be necessary to submit a formal protocol to the Research
Committee of the Medical School. the Medical soard of Metropolitan
Hospital and to the Commissioner of Hospitals of the City of New York.
For this reason. I would urge you not to distribute samples of this
compound

for clinical trial as

you attempted with me.

indicated. I would be pleased to hear
your research division at any time.
As I

from members of

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

cc: Dr.
.,
,w

m

me'rv-

V.

Slotnick

�</text>
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                    <text>February 2‘. 1965

Dr. Joseph E. Barmaok
Chairman

Department of. Psychology
The City College

University of

new York,

York
York 10031
Raw

New

Dear Dr. Barmaek:

It gives me great pleasure to recommend the appointoen:
of Dr. Robert L. Kahn for a teaching position at City College.
I first

one a Fellow

beeama acquainted with Dr. Kahn about 1952 when I
at mount Sinai Boapital in New York. Dr. Kahn was

working with Dr. E. A. Reinstain in studies of language patterns
in patients with orzaeic brain changes. is a resident physician.
I had the opportonicy to observe these studies. I learned mode
from Bob, and in 1955, when I had the opportunity to eerahlioh
my

one raeeereh

join ea.

unit a: the Hillside Hospital. I invireé bin to

During the period 1955-1959. Bob was my codworkar in the
Departaaet or Experiaental Psychiatry at ﬁilleide Hospital. we
were interested in studies of the convulsive therapy process, and
Bob stimulated a wide range of erudiee. including language. social
aspecra. electroencephalography. the California F Scale, and later.
various experimental psychological tasks. It was free him that
I learned to differentiate paychologioal teake ea predictor: of
change in performance. and aa indiearore of change in performance.
Throughout

this period, I found

him

to be a patient

and

understanding teacher and eouworker. Administrative problems
provided hianvith little anxiety, and he was the principal

ioveerigaror in

many

erudiea.

When Dr. Seymour Parlin eoughr to establiah the paychiatrie
unit at nonrefiora Hoepital, I was both pleased and unhappy that
he aaked lob ro-becoae his associate. I regretted Bob‘e leaving
very such, for I felt than. and as I look back, believe now, that
he was an unusual eatelyat ea wall as a etiaularing eo-uorkar.

�pug.

2

I helluva that ha has avary eapacity of

becoming a diatinguishcd

faculty unnbur and would rcconnsnd him highly. He will be ‘ stimulant
to ah. ocudcntc and a loyal co-uorkor to tha staff.
Sincately yours,
Pink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Fabmry

H.
m
N.
188

2%, 196%

G. Barnard

Central

Chytm.

A

mam

63105

Dear Mr. Barnard:
The

dietary army mportad ammmed the control

in
110mm in individuals having acut-bemntal illnesses
an «mm: to datum if there my
dumps in blood
electrolyte chains such disfmcﬂm. We have no study at
the present tin
my plan
for such an max-taking.
man): you for your intamst.
‘

mmmcrﬂesmhmm
Simmly yours ,

m Fink, H.

Director-

M'lja

D.

�</text>
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                    <text>Pebmxy

2%, 196“

Mr. H. 8. Bernard
168 N. Centml Meme
Clayton. Mieeamf. 63105

Dear Mr. Barnard:

dietary study reported unnamed the cmtrol
moesnxy in individuals having acute mental ilmeesee in
The

mafmmmmmifthemmybemmmsinblood

elemlyte daring such diefmadm. We have no study at
mpmeenttimmmingaller‘gieemrheveweenyplm
for such an annexing.
Thank you

far your interest.
Simmly ymm ,
Max

Fink.

Director

W/je

M. 1).

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                    <text>.7.

June h, 1975
Lewis Harness, M.D.
Chairman, Search Committee

University of South Florida
Tampa, Florida.

33620

Dear Lew,

After much discussion among my associates and with
family, I regret that I am undble to proceed with our
negotiations for the position of Chairman of Paychintry. I
truly admire the special unturo or the facilities, the staff,
and the many possibilities at the University, but find that
the effort may be too great {Or no at this time.
my

I want to thank
for your consideration.

you

for your

many

kindnesses and

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mix

ywm

�May

2h. 1975

Lewis Barness, M.D.

University of South Florida
Tampa,

Florida

33620

Dear Dr. Barness,

that I very

appreciated and enjoyed
opportunities are
your hospitality during my visit to
outstanding and the facilities available are among the best I have
seen at any new center. It seems prudent to discuss the many
facets of the invitation with my family and my associates, and I
shall be in touch with you within the next fortnight.
You must know

USF.

much
The

In the meanwhile, I enclose some of the receipts
basis for reimbursement of expenses.

which may be the

Air fate

Taxi (Home to Airport)
Hotel

Total
Again,

my

$176.

8.50

1h.56

199.06

thanks for your kind attention.

Sincerely yours,

Max

Fink,

M.D.

�w.“

—~..W,rmlwr~~m._w..

.

.-.m—-..

-wvvwmmw.” ..,. “Wm rarwwﬁw--."

Lewis A. Bernese, M.D.
&amp; Chairman

Professor

Department of Pediatrics

Tampa General Hospital
Tampa, Florida 33606

Dear Dr. Barness,

for the invitation to visit Tampa and
I have scheduled the flight, Delta 17? leaving
LaGuardia at 0900 and arriving Tampa at 1132 on Tuesday, May 20.
As I shall be going on to Miami Wednesday afternoon, there should
be enough time to visit the installations of the University and to
meet the faculty.
Thank you

the medical school.

I shall be prepared to present a discussion of
"Studies of Chronic Hashish Use", reflecting on the studies in
which I have been a participant since 1969, both in New York and in
Athens, Greece. I should like to review the clinical, behavioral,
and physiologic effects of cannabis use, both in a community of
chronic users and in experimental subjects.It should give the audience
an opportunity to enquire into the relations between laboratory and

field studies.

It

to read any material describing
its facilities, and its present
and projected programs that may be publicly available. I should be
grateful if your office could share such material with me.
would be

helpful for

the dIIelopment of the medical school,
Again,

my

me

thanks for your invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_..

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                    <text>May 20, 1987

Samuel Barondes, MD.
Department of Psychiatry
University of California, San Francisco
401 Parnassus Avenue
San Francisco, CA
~

‘

9“”

Dear Dr. Barondes,
At your request, I am writing this letter regarding the promotion of Dr.
Edward Merrin to the rank of Associate Professor. I do not know Dr. Merrin, and“
was not acquainted with his writings before reviewing the publications sent to me.
I am impressed with the quality and sophistication of Dr. Merrin's research
studies using quantitative. EEG methods. His choice of problem (laterality in
schizophrenia) is timely and important; the methods used (power spectral analysis,
unlinked reference leads, medication controls) are reasonable; and the quality of
the reports excellent. The latter are clearly written, and Dr. Merrin uses good
statistical and data processing procedures.

These studies are important and they reflect an interest that should
continue to be productive in the forseeable future. It is difficult to assess the
importance of these studies in the field, since there is much activity and little that
has been conclusive. These studies of laterality are well done and must be
considered in any further studies of the problem. And, as a young investigator, I
believe that these reports are of high quality, comparing most favorably with other
reports in the field. For example, he has not made the glaring errors of Duffy, E.
Roy John, and Morihsa, who failed to control for handedness, drug use, and
electrode montage in their conclusions (which have since had to be retracted.)
Dr. Merrin’s clinical reports are also well written and useful. I am unable to
assess the studies of saccadic eye movements, since I am not conversant with the
theory of these studies.
_
i have examined his list of Departmental, V.A., and University teaching
responsibilities, and these seem consistent with his rank. I am, of course, unable to
assess their quality.

To the extent of this review, I am impressed with Dr. Merrin's reports and
output, and would have no difficulty in endorsing a recommendation for his
promotion to the rank of Associate Professor at this University. I am comfortable
in making the same recommendation for the University of California, and
recommend Dr. Merrin's promotionwithout reservation.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

'

‘

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                    <text>must

1n , 1967

Dr. Michael C. Barry

Assistant Medical Director
White Laboratories , Inc.

Kenilmrth,

New

Jersey

DearDr. Barry:
Some

weeks ago you

visited my laboratory

and we discussed

the possibility of a high dose and very high dose fluphenazine
study program, to be mderrtaken at the University of Istanbul.
My associate, Dr. Itil, has sent you sane of the references

whichyouroquestedandhasaskedmtosendyouaoopyofthe
revised protocol, which is enclosed.
Tim you for your consideration.

Sincerely ywrs ,
Fink, M.D.
Profassor of Payohiatry

Max

MF:kp

'

.

,

“.uvmrv‘mr'um'z‘.

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                    <text>September l8, l967
Dr. Michael C. Barry
Assistant Medical Director

white Laboratories, Inc.
Kenilworth, New Jersey
Dear Dr. Barry:

Both Dr. Itil and I are grateful for your consideration
of our request to undertake a study of fluphenazine in high
dosage in the populations in Istanbul and St. Louis. Your
willingness to file the necessary forms for an IND with the
Food and Drug Administration will be most helpful.
Our estimate of the supplies necessary to undertake th
study in Istanbul is as follows: for 20 patients, l0 weeks
observation at 400 600 mom/day will require 700 gms
fluphenazine. To provide for loss and drop—outs we will
ask a supply of lOOO gms.
—

best form would be in liquid concentrate, at the
palatable concentration, but not less than 20 mgm/cc.
the
concentration
If
is 20 mgm/cc, the amount will be 50 liters.
The

maximum

If tablets are more feasible, then 50 and 100 mgm tablets
should be considered, and the supply requested would be 3000
tablets of 50 mgm and 7000 tablets of l00 mgm.
discussed, we will try to obtain the funds necessary
for this study by diversion from other study programs, but this
source is limited, and we would ask White Laboratories to
consider an additional grant-in-aid in the amount of $l.000.
As we

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. Itil
Dr. Polvan

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                    <text>"v

4;:

neon:

I

.l.‘

.L

~»

or

",7.

.
.,

"um",

December 13, l967
Dr. Michael C. Barry
Medical Director

Assistant

white Laboratories, Inc.
Kehilworth; New York 07033
Dear Dr. Barry:

I have arranged for the concentrated Permitil to be
tested in Istanbul by Dr. Necmettin Polvan. He has just
written to me that the form is agreeable. I would be
grateful if White Laboratories would supply us with a
similar concentrate of approximately lGDmg/cc. If we plan
to treat 40 patients for a 3 month period, I estimate that
we will need 360 grams.
I would

like to file the necessary

ask your help and advice as to
Thank you

how

FDA

forms and would

to go about this.

for your cooperation.
Sincerely yours,
'

Fink, M.ﬂ.
Professor of psychiatry

Max

.L

L

t
.

w.

,

MF:kp
..

«It»

.

F

an

on".

L.

_.

u...~..~I-I-o

L-

�</text>
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                    <text>35::

v.-

u",
m

vow-

:w
m

«nam-

Y.»nq7;'l«"M"

harch 28, 1968

.4
1'

-

/,.

xvr‘w‘

icw:'.4

men-mm:-

Dr. Michael C. Barry
Assistant Medical Director

'thite

Laboratories. Inc.
New Jersey 07033

Kenilworth,

Dear Dr. Barry:

visit to the Department of
of
Istanbul, where I met our
Psychiatry it the University
examined
some of'the patients receiving fluphenazine.
coworkers and
You may recall that we sent them a supply of fluphenazine concentrate.
A few weeks ago, in order to keep the study going, we sent a
small supply of higher concentrated tablets iron France. I
examined the records and saw 7 patients receiving high dose
fluphenazine.
I have

Just returned

from a

‘

‘

’

-

_

Three of the patients who had

failed to respond to standard

doses of phenothiazines have shown a dramatic improvement with
300 to 500 mg of fluphenazine daily. 0f the 7 patients, 5 had
received between 100 and 600 mg daily, up to l0 days. ~In one

patient

I saw

was ninimum
patient who

extrapyramidal'symptons but in the others. there

rigidity, obvious only on fine testing.
exhibited the most rigidity was part of

series, receiving

30 mg

daily.

I was most impressed

that the very high dose

The one
a low dose

was

safe (in

7 patients) and apparently useful.' Dr. Polvan-and his associates
are continuing, within the limits of the medication available.

this

may soon become available so that
Thank
you very much far your cooperation.
study can continue._
I

trust the concentrate

Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

MF:kp

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                    <text>May

10. 1968

Dr. Michael C. Barry
Medical Department

white Laboratories. Inc.

Ksnilworth.

New

Jersey 07033

Dear Dr. Barry:

Enclosed

is

a proposed Statement of

Investigator

Form (FD l572) for the high dose fluphenazine study.
In addition. I am enclosing copies of the report presented
at the CINP and a summary of the proceedings of another

related confsrencc in Sitges, Spain.

Please edit these and the proposed project to your
satisfaction. I look forward to hearing from yen.
Sincerely yours.
Fink. NJ).
Professor of Psychiatry

Max

HF:kp

cc: Dr.

Itil

�</text>
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                    <text>3..

p—vv—w

October

l8. l968

Dr. Michael C. Barry
Hhite Laboratories
Konilworth, New Jersey 07033
Dear Dr. Barry:

l57l for fluphenazine hydrochloride, oral
lOO mg/ml has been submitted to Br. Merle
Gibson at the Office of New Drugs. Bureau of Medicine.
Copies of the submission and the letter of transmittll
are enclosed.
The FD

concentrate,

Would it be possible to ship one-half the supplies
of the concentrate directly to or. ltil at the Missouri
Institute of Psychiatry (5400 Arsenal Street. St. Louis.
Missouri 63l39)? The supplies for Istanbul should be
shipped to me for transushipment as soon as the proper
clearances are provided.

Dr. Itil Joins me in expressing our gratitude to you
and to white Laboratories for your faith in this preposal
and your diligence in making those supplies available.

Many

thanks.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry
Max

�</text>
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                    <text>Jmuery

ll ,

1966

Dr. Walter E. Berton, Medical Director
American Psychiatric Association
1700 18th St” N3.
Harrington, 0.6. 20009

mar

Dr. Barton:

I

am

writing vim regard to the proceedings of the

nosology cmfermce. The draft which was mimogmphed as
program paper No. 31 was a penultimte copy and I submitted

toDr. Ketzwocopiesofelatermft. Formreconis,
I am enclosing two edited and revised copies of the draft
for your consideration for this

volume.

'Ihe mats recorded by the typist odd little to the
text since I elected to use the time available to me to
summarize the salient feetms of my report. For this
reason, I think publication of the report alone is satisfactory

and these cements ought

to be deleted.

Hmiltm, in discussing this report, raised a
of salient issues. Unfortunately, my notes. of his
questions have been misleid. If a draft of his discussion
related to prom paper No. 31 could he made available to
m, I will edit this report to answer some of his questions
or provide you with answers that could be included in the
discussion if his discussion is published.
Dr. Max

umber-

It was s pleestme to participate in this
volume
do

I believe this
future

mom.

will

web to provide

program and
as

facts for

Incidentally, in mower to your request at the meeting,
the following is en up—to—dete description of my present

�m. Barton

We affiliatima:

January 11, 1966

~2~

Max

Pink, 1“).

meessor of Psychiatry

Dam-mun of Psydxiatry
at Missouri Institute of
Wydﬁatry

Missouri School
mimity of of

Maine

Reward": Professor of Psychiatry
Washington thrivemity School of
Medicine

Sineerely yams ,
Hm:

Pink,

24.1).

meeam of Psychiatry

map

�</text>
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                    <text>January

25 , 1968

Dr. Walter E. Barton

Meal Dimmer

‘

Mariam Paydﬁatrie Association
1700 lﬂglrteexm‘x Strut, NJ .
13.3. 20009

Wu.
mm.

W:

Hr. Robimonm‘kixﬁemmhtowndmampyof
Er. Hanilton'a
on maolog.
at the
I haw: read these. mmmw that I'have already taken
into
his witicism in the draft submitted to you
must- this mum. Plum wider that M1: as dafinitive

mm

mum

mt
anddiscwdthempy aubdttodatﬁntimofﬂmmnfemme.
m.
51ml}:
Many

yams,

Max

m. Md).

Professor of laydﬁatxy

1‘?sz

�</text>
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Rama

E.

W,

H.115.

mmctor
ﬂiviaion of Mtibiotic

Acting

Drugs

Department of Health, Education, and Welfm

Washingtm, 13.6

W I».

W:

is a Xeromd mpy of the literature review by
Dr. Simm. dated July. 1965. and a list of the eitatims
smich pmvidcd the Main for our intranet in thin amrimmt.
Enclosed

Inthemigiml pmpoul,mhadplarmdtomcplom
We

the effects of the

Wamtim of tryptophan.

ham

mtasyetmdamakenthispmoftheetudy,anddomt

plmtodom.

Sitmrely yam,
'

m Fink,
Professor of Psychiatry
M¢ Du

'

HF: 5m}:

Enclmm

�</text>
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                    <text>May

20,

1-953

Mr. William Mm.
(arming City Steal (Emmy
20th a State Streets

Mite City.
Dear Mr.

Illinois

8am:

mums"

Enclased is an interim
1%me pmpamd
Samara. mac capiaam sent for your
nfmtim
may. The original is being pmpamd and will be mﬂmitted
to the Natioml Institutes of Health fer a autumination of

w

Mr.

our- overhead

Wage allowance

for future grants.

Sincerely yours ,

.

m, Dinner
Emwtiva
Max

Mfume

one.

H. I).

v

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                    <text>June

I“,

1963

Ismmmmmmnmmmmm
~‘
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(m) atﬁuWInstitum sf Way.

mm

.‘

misamotmmmmmtmm*mmmimt
Mkmsydnplumﬂmlogh’. Hohasdmcoutstmmmwm'konm
antimofmmsmpsymwlow.

mmmmcummmmmmmuy
Primipal km Wat (mum) at tbs
maxim
Imtituu cf Psydxistry.
musbomintenstod

Ni

,3

Dr.

‘

fwmmintthoyofmﬂdwﬂmisdmgs-m
mmmmd,1bs1hvs.hnwinbdmtothismictyanmml
.

-

’

i

.

'

Mmpissofthmimﬂmﬂtsofawhofﬂnssmis
for the
maimed

Whip Mme.

‘

1
.

my much far your mﬂsmtim;

“thank you
'

Sinatra}? you“.
HISEOURI

Imam: 0? WWW

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Max

Him-I

Fink, n. n.

j

'

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                    <text>Hard! 31. 1965

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                    <text>Jun. 2 ,

m.Wis,mu.

Willim R. Basses, Esq.
Bonn-t9:

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8111:

81:.

Wm t

Bank Building

W

{ﬁnancial mtmrt of the
The mly noctim that mods uplamtim is

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thnmtfwweeks.

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‘w

put": ,., “—TTV.V-.W.-‘,,~-IM.....E rm.-&gt;Tlm'~m'n:m’ my.-

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v

ivy-vawur

July 28,

Mr. William R. Basoan

Messrs. Bryan, Cave, McPheetem
1630 Boatmn's Bank Building

8

—n-'w;v:‘nr‘—,“‘I'

»v.mL—u—w—r.«._~v; :

u -.m-

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1965

McRoberts

St. Louis, Missouri

Dear Bill:

maimed is the Certified Statemt of the Foundation’s
Accounts as of June 30,1965. It has been a good year
firmncially and the Fomdatim' 3 cash balance is slightly
more than $30,000.
The bank balance is approximately $9,000 with the
remainder of the Pomdation's fmds in U. 8. Treasury
Bills maturing at various times between October 7, 1965
and Jmuary 20, 1966.
My

best regards for a pleasant

summer.

Sinoemly yours ,
Pink ’ M. D
Executive Director

Max

mm

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                    <text>October

Mr.

wmm R.

Mum.
1630

Ram's

Bank

Him

Warn New:

Building

8

.

W

Mound is a “amount of th-

Foundation as

, 1965

Batman

Bryan. Cave,

unis,
M8111:
St.

1‘!

of

position of the
fimialI has
just remind

30. 1965, mic):

mmmsmy.
this qmrtur mmMnmaofmsominm
the
of the Institute
ofmymﬁmhmuhmmmmmr
andtheg
carry
mticipmo an additional Mica].
mm“.
haunmrdsdwingﬂnmxtsixthun-udmsmmuabh
to
a mum
fw the
may
of
this
despite
oquimut
yam.
manta
mm
m
I
Wm
during

equipment nood-

We

WWW

maintain

balance

which

now

01'

$15,000
and

hold.

Mauditorfortmmﬁismmvmkingthiamk,md,

scramhehasfomdmomptiminanyofourmtmts.
Ilook

fommmwingyoutmmm.
Sincerely

MFﬁmh

yum,

Max Fink, NJ).
Executive Director

�</text>
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                    <text>Juno 22, 1964
Hiss L. E. Bastiaans

Editorial Assistant
Elsevier Publishing

Company

P. O. Box 211
Jan van Galnnstrsat 335

Amsterdam, The Hothsrlsnds

Dost Miss Baatissns:

I

am enclosing hstowith the proofs of the first 32 pagos of
the bibliography and a new set of proliminsty pages.

Dr. Bouthilet and Miss Ctomwell have rsquested that they not
be listed as authors of this bibliography and for this reason
I have doletod their names from the first page and on requesting the insertion of an acknowledgment in the appropriate

portion of the introductory pages. In addition, since the
conplotion of this bibliography has been undertaken by other
assistant: at the Missouri Institute of Psychiatry, I would
prefer that the acknowledgment to Hrs. Brown and the other couorksrs be listed in the acknowledgment section.
I have no objections to not receiving further rsvisions of
these pages. except that such a publication is only of merit
if it is flawless. In the event that your typesettets and
prooirseders believe that there still may he errors in the

text. I would be pleased to have another set of proofs which
I can return within £8 hours. I shell trust that you will

nuke the decision with these facts in mind.

Sincerely yours,
Max

Fink,

Dirtctor
HF/jb

M.

D.

�</text>
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                    <text>June 29. 1964

Mia. L. B. Baotiaans

Editorial Aaaiataut

Blsovior Publiahiog
P. 0. Box 211.
Jan van Galenatraat

Company
335

Amsterdam. The ﬂethorlondo

Dear Mina Baatiaans:

I an pleased to analoso a copy of the corrected page proofs of
page. 33-68 of the Bibliography.
have checked tho oubject index and have indicated our aug~
nested corrections for those which you questioned. I do not
think another set of page proof: on than: page: in at all nooseaary. I wish to congratulate you on a job well done.

we

Please not. that my associate questions the capitalization of
rotatonco #461. and we will abide by your determination.
Sincoroly yours.
Pink,
Ditoctor

Max

MF/jb

M. D.

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                    <text>July 15,

1964

Miss L. H. Bastiaans

Editorial Anuiatant
Elsoviar Publishing

.

Company

P. O. Box 211Jan van Galenstraac 335
Amsterdam. Th. Hatharlandn
'Dear His: Bastiannn:

Minn Roscnfcld has brought
125 has a minor error. If

.00

my attention that our citation
this can be corrected. please do

to
'

m

articln by De Grdgorio a: a1. lppaau in Valum 24-74 of
Annnli di Freniacria e Scienze affini, instead of Volume 24.
Sincerely yauts,
Bax Fink, M. 1).

Director

MF/jb

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                    <text>"Y0“.—

1““va

acme-ma

July 20, 1964.

also L. B. Baottaaoo
Editorial Aaaiouant

,

Eloovlor ?ub11ahing Conoany
P. 0. Box 211
Jan van Golanotraot 335
ﬂoatation, Netherlands
Daar Elan Baociaano:
Tho preliminary
IV aaaoeiatel.

'10

past: are ancloood as corrected

yourself

aad

Charla: c Thomas. the publlaher. is correctly cited as‘
C. C Thomas. The oocond "C" apparontly dooa not rap~

tosont an abbruviatloo..

2.

by

An

‘

I rovlow thoao pasao. I an snort that I

acknowledged tho

haw: not

aarliat bibliographic collection of

Dr. Mhry Brazlar. notoronoo should be made in the
introduction to hot oarltor bibliography as lt rop~

resonta on oscillont collection of earlier drugs!and
EEG. If agroooblo to tho editor and publiohar,1
would nah: two suggestions.

a. Ciao the earlier journol oupplanont

1n the

intro“

duoclon by adding a now paragraph between pauagtaphs

l

and 2 as follows:

this bibliography aopplomonta the earlier "Biblio-

graphy of Elacttocnoaphalostaphy. 1875~1968" cdttod

Wei-m»
by Mary A. B.

Brazier.

2

h
Swplmnt 51. 1950.
co

b. In a vacant summary of hot experiences with the
aftacto of drug: on tho aleotrocneephalogrom of
nan, Dr. Brazier concludoo with a statamont.that
oxpraoaoa my personal vita of these studios so
wall. that I would bo plooaod to haw! this paragraph citad as part of tho introductory remarks.

�—

,
v4

,-

v."‘-'"*w‘w-D'Imwv"3

Miss L. H. Busctaana
7-20—64

Pas.

Two

—-

2.b. (continued)
;&amp;

mums:

”19:11-

In recent lettorn with Dr. Braziar. she has given
this caccion. a copy of

no permission to quote
which is enclosed.
Would

the editor connldur the reproduction of
and citation as a separate praise:

thin paragraph

pace?
Thank you.

Sincerely yours,
Mn:

Fink,

Director

nrljb
me.
cc: Dr. A. Harsan

M.

D.

�"to the eltctrophysiolagtlcgccuscomnd, in his animnl‘
sxﬁtrimnntl. to probing with his ﬁlcétroda into ch. norvoﬁn
.ayutam and-even into the naivu.eall

itself, it

mattcr of astonishmknt that so

5f"tha brain‘s uncretu‘

many

tannins a

ascgnd across ch; wall of the skull ta alec£rod¢s fixnd

to'r

do so is
upstimnny to
thc-acalp_o£ man. That thay inﬂatd

thc £n§t thAt the brain’s clcctr1¢51.£¢t1vity 1: a most

“mum tndicatorof

its imetién.

In this

act

lies the

.atgraction of eluctroanccphalosraphy for 1th devotnaa."
Brazier (1°64)

Mary A. B.

From "The

Han".

Effect of
.

102~116,

t

Drugs an‘thé Electronncephalogrnm q£_
4

J.

.'

!
.

w.

..

(Jlnﬁ). 196k.

,

t

‘

L

=

'21 B, 5:
”

�</text>
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                    <text>July 28,

1964

Miss L. B. Bantiaana

Editorial Assistant
Elaavia: Publishing

Company

P.
Jan van Galanatraau 335
O. Box 211

Anatatdam. Natharlanda
Dear Miss Bantiaana:

I hava just recaivad a coﬁy of tho lettcr of Dr. Maraan, in
which ha concura in eartain additions to tha preface. I accnpt hia auggaatiana.

'

Encloaad is a Zara: copy of tho section of the Brazier
which I would Ilka addad.

Sincercly yours.
Mu Fink,

Director

Mlljb

Inc.

.

w“,

..

A.,.,

,
V,

&lt;
v

...

A

1.-

”we.

.v—ww—Aw-~,mu—V'-r~w-w~——ur‘“u-..

Mo Do

articla

�</text>
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                    <text>February 23, 1967
Dr. Robert C. Batterman
Clinical Pharmacology Research.Institute
2030 Haste Street

Berkeley, California 9u70u
Dear Bob,

It

was

a pleasure meeting with

you again

in Lexington

I very much enjoyed discussing your study program. As
that I will be in California in the near
is
it unlikely
am
this opportunity to request cepies of
I
taking
future,
center which may be related to psycho~
frcnxyour
any reports

and

active or anti~anxiety agents.

Incidentally, your description of a two-point pask as

an index of drug
My

effect,

was a most

interesting suggestion.

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

max
MF:kp

�</text>
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                    <text>,)
.

k.

""F'rnwwﬂ'fdivv‘ﬂ3w_-vx-&gt;;-‘\

‘k-¢_«

1.".

.w

July 20,

mum-quay,“

1969

Dr. William Banana

v-vnran—x-wnmm-r

Presbyterian Hospital
New York City

.nuwmtvwl:wr,so'l

Dear Dr. Banana.
um,“

“gr

“—7..

”NW.

Thank you for your invitation to aprtictpate in the
nearing of the New York State Radical Sociory. Fob. 8-11. The
subject of computaro in medicine in of inturcur to no. and I would
1970

be planned to

participate.

A: you well know, the current arc of computers in
psychiatry is limited to a few research applicrclonc, but the programs
now in trial use are quite interesting, so that the ropic of the next
5 years can be adequately counted.
1

look forward to

participating.

enra-

sun;

Sincerely yours,

,
-«

:mmxgrmvu

a."

,

wwmv-ww

Max
;-._uq,,-

r;

‘w—wﬂlﬂrwv

,rr:.~11

.muw

m

r
..._

Yink, M.D.

Professor of Psychiatry

1—?

mf/

�</text>
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                    <text>i
E

r
F

January 14, 1971
Bay Roc Hotel

Montego Bay,

Jamaica

Gentlemen:

are planning a 3*day scientific conference for
October/November 1971, for 40 participants, and an additional
20 accompanying family members. Your facilities have been
recommended to us for this meeting. we have not yet specified
the specific date, and I am writing to inquire as to the
We

availability of accommodations,
conference

facilities.

and

the costs, including

What

are the probable weather conditions in the second

Many

thanks.

half of October?

Sincerely yours,
Max

Fink,

M.D.

Executive Director

kt

�</text>
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                    <text>Soptcmbtr 11, 1964

Dr. Faruk Bayﬁlkem
Bakirkoy Akliye we Anibtya Hantanesi

Sertabtbi
Istanbul, Turkey

'
.

Dear Dr. Boyulknsu

I want to take this opportunity to thank you for the opportunity to prosent some of my work to your staff. I enjoynd
my visit to your hospital and to Istanbul very much. and
look forward to visiting with you again sumo tin: in the

tutu“
I

am

o

some of my
you and some of your

enclosing copies of

of incarnat to

reprints

staff.

wﬁich may be
'

Sincerely yours,
Fink,
m
Director

mm
was

Mo Do

�</text>
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                    <text>W
PM
Akliyeuva
Mn

Bakixkoy

W
”

Wyn
- IstanbulEmmi

12, 1965

Wibi

My
Bentham:
mm.1muudandymtim,mwimw
in adder
application for a new“ $11:
mwdiﬂmlinfmimtobe
mpmvidethy
Mnmlnmntoﬂnenmittm
mammmyofn
thepmont
Wham. Faltmmdmulf dean-w

“My

pmm. hmldhnmtnfulfnrmymimywm
given" Wyndham!!!»
Ilodtfmmtomimymmxtsmv.
smartly ymm,

Fink, $1.1).
m
Professor cf Paydaintzy
.

Wakp
cc:

Dr.

Itil

DP:

Palm

Em.

Kaskimr

Dr. Clause

�</text>
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                    <text>July 6, 1971
Dr. Gilbert Kayne
Merck, Sharp 8 Dohme
wast Point, Paunsylvania 19486
Dear

Gil,

Enclosed are two articles from the book “Narcotic Drugs
Biochemical Pharmacology”, edited by Dorothy Clone: and publiahed
by Plenum.

Have a

nice

summer!

Sincctgly yours,
Max

Fink, “.0.

Professor of Psychiatry

�</text>
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                    <text>'7
""

v

‘

'
'

"WWW“

0mm

July 31, 1970

"im‘véibmu-‘F‘Usv'ﬁ‘vsvm

,1.
rm

ﬁnger,»

;

ﬁfiss Josephine Baeala
Executive Socretary

NCPS

San Francisco

'x-vmmgz—wv.

:rvgg..gn:-:-z--

Dear Miss Beale,

v7?

:4;

W?

51.2;

wgv

«a

:

'7»:

,-.-»v1-mww’-“ﬂ1wmw

Dr. Michael Taylor is one of the best qualified residants
to have graduated our training programs. He has a brilliant future
ahead of'him, if he disregards the frivolous dbmando of organized

medicine ana ps~zzchiatry.

a resident, he
intelligence above his pairs.
Ag

pleasure to see him assume responsibility for patients and
for nis research projects. He shared the 1989 research priae of
the society for Biological Psychiatry with a fbllom rcaidknt.

was a
m~ww17ﬂxi¥fff

I am pleased

{1552!}

raw-“r

_:ﬁjf’vv‘“

z
i-

AVTJ'.’

initiative, industry and
is sincere and honest and it

showed
He

to

recommend him to the

society.

Sincerely yours,
[jaw Fink,

33!.

Do

Profhaaor of‘Psychiatry

mﬁ/

�</text>
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Mark S. Beaubien, M.D.

Assistant Chief, International Cooperation
and Geographic Studies Branch
Fogarty International Center
Dept. of Health, Education &amp; Welfare
Rational Institutes of Health
Bethesda, Maryland 20205

Dear Dr. Beaubien,
Dr. Drigoltav V. Ereegovse visited our facilities during
week of October 29. He toured our Health Sciences Center,
observed EEG recording sessions in volunteers and discussed our
EEG methodology; visited our V.A. clinical study unit and observed
modern methods of ECT and discussed principles and theories of ECT.
we fOund him to be a delightful visitor and guest, and we hope that

the

we

contributed to his
Thank you

"ETA".

for referring

'

him

to us.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:bo

�£1239£0537

9’9

R

,

$0M];

/

@950 75% 30’
§:P

A

{90

(7‘94:
I

0'
f/if?

q

5951

71/
.

July 17.
MBrk

1979

8. Beaubien, M.D.

Assistant Chief, International Cooperation
and Geographic Studies Branch
Fogarty International Center
Dept. of Health, Eaucation &amp; Welfare

National Institutes of Health
Bethesda, Marylanﬁ 20205
,Dear Dr. Beaubien,

We would be pleased to hava Dr. Ercegovac visit our laboratorics
during the week of Octdber 29, 197§. It would be helpful for
Dr. Ercegovac to let me know what aspect of our studies interest him.

the

I suggest he call

visit.

me

at

516~hhh~2hh7

'

in September to discuss
Sincerely yours,
Fink, 14.1»;
Professor of Psychiatry

Max

MF:bc

3,?

�</text>
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                    <text>w— wmr

“rte—“m...

,,

~

Few»,

ewe—prim.. v-sw-W—wnrr‘wv—‘m'mv-a,“ anarmwwwwmwwe—w,

.

,

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_

Ref: 72-321 I
June 28, 1972

Michael Beaubrun, M.D.

Professor of Psychiatry
University of the West Indies

Mona, Kingston, Jamaica

Dear Michael,

I regret that

we

have been unable to obtain a contract for
at this time. It seems that one hurdle
is permission from the State Department

the cannabis studies in Jamaica,
that we cannot overcome directly
to undertake these studies.

Two weeks ago, when we spoke, I called Dr. Smith at NINE
and assured him of the answers you gave regarding the premature
release of the data. Not hearing from them, I called the contracting
division last week, and was told that it was too late to support the
study this fiscal year. I called Dr. Bunney, and after some discussions

with others, permission was given to fund the contract out of this
year's budget-- provided State Department approval could be obtained.
When the question was raised in Jamaica, apparently, the negative response
was sufficient to push the discussions to the next fiscal year.
Should you wish to proceed, I would suggest you enquire of
Dr. Jean Paul Smith or Dr. William Bunney, for an official interpretation

of the status of the application.

would be prepared to write a letter to the Secretary of
State, indicating that this Association has had experience in Greece and
that we have a good record; that it would be sad for the program to be
We

aborted because of the misbehavior of someone over
cntrol, egg.

whom we

have no

Incidentally, the 'worksheets' prepared by Dr. Smith, Dr.
Szara, Miss Carroll, and Dr. Petersen are most satisfactory, and I do
believe they were prepared (or are prepared) to see the program through,
if the administrative hurdles can be overcome.
Regretfully,
Fink, M.D.
Executive Director

Max

p. rm“-

, "1..“

�</text>
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                    <text>June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�</text>
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                    <text>1

4
.1.

my

L‘

May

13, 1971

Dr. Michael Beaubrun

University of

Indies

West

Kingston, Jamaica

Dear Dr. Beaubrun,

you by

my

I very

phone

obtaining as

enthusiasm

much

regret the inconvenience I

call yesterday.

much EEC

may

have caused

interested in

are
gets as possible regarding cannabis, and
very much

We

may have overcome more

rational considerations.

my

In View of the time in your study, and considering the
expenses involved, it may be that an intervention now will not allow
for sufficient data to be collected. Should you and your associates,
however, find the way clear to renexamine sufficient subjects and
controls to extend the study, we could then assist your analysis
with our quantitative techniques, and I am confident that funds can
be found to do 30. Perhaps you will review the possibilities, and
let us know whether and how we may be of assistance.

Separately, I am sending you a few reprints of our work,
including a preliminary draft of the cannabis—EEG report to be
presented in New York next week. These may be of interest to your
neurophysiologiet, and should he wish additional information, we
would be pleased to oblige.

quite stimulated

by

tell

I very much enjoyed and was
the presentation in Washington. Your study

Again, I wish to

you

promises to be one of the finest of chronic cannabis use, and I look
forward to hearing more of it.
‘Hy

best regards,

and

my

apologies for the inconvenience.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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awn"

-

'

,...-....

Dr. Michael Beaubrun

Professor

November 2, l97l

Chairman,
Department of Psychiatry
University of the West indies
Kingston, Jamaica
&amp;

Dear Dr. Beaubrun,

After considerable delay and consideration, the application
for the study of chronic cannabis use in Jamaica has been forwarded to
Washington. i have held prior consultations with various of the officers
in Washington, and have been told that this study, with the one in Greece,
has a high priority, but that funds for the l97l~i972 fiscal year for
these contracts haze not yet been approved. Approval is expected this
month, and these applications are in hand in time.

studies

have also requested the letter of interest
lnstitutem and this is under consideration.

i

by the

in such

It was most useful to have Mr. Beecher, and i trust he
do not know whether some funds are necessary from
enjoyed his stay.
our study program, but if there are some that may be useful, please
I

write to

me.

have asked Dr. Dornbush to write to Mr. Chevannes to
apprise him of the timetable and to enquire as to his cooperation, since
he indicated that there may be a change in his status atbthe end of the
year.
i

duplicate copy of the proposal is enclosed for Professor
told you, i did discuss his budget with him and
the budget as submitted includes his requests (modified) and your own.
i would
urge both of you to review the details, and assuming our NIMH
will support the study, will ask you to confirm that the summary includes
the items necessary.
A

Ward. As he may have

have also sent a copy of the proposal to Dr. Henry
U.S. Marijuana &amp; Drug Abuse Commission. I understand he
will be visiting you next week. i have asked him to present the prOposai
to his commission for support, for it may interest them as much as our
National Institute of Mental Health. Should he raise questions regarding
I

Brill of the

.W. .srw.r,_.7,m_,_

�z
‘

_-W——w——-——w—e—

Dr. Michael

'r-‘u'l-Iw

,

T—wv'vr'IW-‘m _——W_.._..._
.

Beaubrun..........November 2, l97l

wuss-aura:

m m.

....__w——.—..&lt;~v-_—-..e«ww

...........................2

w-«w—

this proposal, it would be helpful for you to be as candid as possible.
Brill was responsible for establishing our study in Athens, and has

Dr.

maintained a deep

use.

year,

i

am

interest

in the possible consequences of chronic cannabis

Anticipating a faborable response before the end of the
proceeding with orders for the additional equipment on a

contingency basis; and have scheduled visits to Jamaica immediately
after the New Year. it should be possible for one of these funding

agencies to indicate their position

by

early

December.

Meanwhile, should any data from the population survey
available, it would be helpful to provide these in support of this
application, and I would appreciate a copy as soon as possible.
be

shall be attending the World Congeess of Psychiatry
at the end of the month, and shall look for you. My
best regards to your wife.
i

in Mexico City

Sincerely yours,
Fink, M.0.
Executive Director

Max

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                    <text>November 2, l97l

Dr. Michael Beaubrun

Professor

Chairman,

&amp;

DeparTmenT of Psych iaTry
Univers iTy of The Wesi indies

KingsTon, Jamaica

Dear Dr. Beaubrun,

for

AfT er

The sTudy of

considethle delay

chronic cannabis use in

and

considsraTion

The

eraica

applicaTion

has been forwarded To
have hel d prior consuiTaTions wiTh various of The officers
WashingTon
in “ashinnTon, and have been Told ThaT This s.udy, wiTh The one in Greece,
has a high priorlTy, buT ThaT funds for The l97l-l972 fiscal year for
These conTracTs hose noT yeT been approved. Approval is excecTed This
l

monTh, and These

applicaTions are in hand in Time.

have also requesTed The leTTor of inTaresT in such
lnsTiTuTem and This is under consideraTion.

l

sTudies by

The

lT was mos T useful To have Mr. Beecher, and l TrusT he
do noT know wheTher some funds are necessary from
enjoyed his sTay.
our sTudy propram, huT if There are some ThaT may be useful, please

i

wriTe To me.

l
have asked Dr. Dornbush To wriTe To Mr. Chevannes To
The
him
TimeTable and To enquire as To his cooperaTion, since
of
apprise
he indicaTed ThaT There may be a change in his sTaTus aTbThe
of The

.year.
A

duplicaTe copy of The proposal is enclosed

his

for Professor

Ward. As he may have Told you, i did discus
budgeT wiTh him and
*The budgeT as sulmiTTed includes his reques Ts (modified) and your own.
i
would urge boTh of you To review The deTails, and assuming our NlMH
will supporT The sTudy, will ask you To confirm ThaT The summary includes
The lTems necessary.

have also senT a copy of The proposal To Dr. Henry
The U.S. Marijuana &amp; Drug Abuse Commission. I undersTand he
be vlsiTing you nexT week. i have asked him To presenT The proposal
I

Brill of

will
To his commission for supporT, for iT
NaTlonal lnsTlTuTe of MenTal HealTh.

may

inTeresT

Should he

Them

as

much

as our

raise quesTions regarding

�h

Dr. Michael

Beaubrun..........November 2, l97l

...........................2

if wouid be helpful for you To be as candid as possible.
was
Brill
responsible for esieblishinq our siudy in Afhens, and has
mainfained a deep inferesf in iho possible consequences of chronic cannabis
This proposal,

Dr.

use.

year,

faborable response before The end of iho
proceeding wiih orders for fhe addiiional equipmen+~on.a
Anficipaiing

I

am

a

contingency basis; and have scheduled VisiTs To Jamaica immediafely
afier The New Year. if should be possible for one of fhose funding

agencies

+0

indicaie fheir posifion

by

early

December.

Meanwhile, should any daia from ihe populaflon survey
would be helpful To provide fhese in supporf of This
i would
appreciaie a copy as soon as possible.

available, if
applicafion, and
be

i

in Mexico Cify
_

bes? regards +0

shall be aiiending fhe World Congeess of Psychiatry
+he end of ihe monlh, and shall look for you. My
your wife.

ai

Sincerely yours,
Fink, M.D.
Exocufive Direcior

Max

�</text>
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                    <text>”.17.,

w

.v-a-gw-yn...

November 18, 1977

Michael H. Beaubrun, M.B.B.Ch.
Department of Psychiatry
university of the west Indies
Kingston, Jamaica
Dear Michael,

our project in Athens
and the report has been published earlier this year. At the 1976
meeting at the New York Academy of Sciences, there was agreement
among the reporteds from Jamaica, Costa Rica and Athens on the findings
of the three studies. The reports of Sonic! and Chopra, however, were
discordant.
As you know, we have completed

former associate of mine, John Kramer, has been active
in research in opiates and amphetamines. He was a consultant to Jerome
Jaffe at BAODAP. In some discussions last fall, I enchuraged him to look
‘at the discrepancy between the sttdias reported at the Rev York Academy.
A

s dialogue.and we have been struck by the
reports by Dr. Frank Knight from your Department. John has written to
Dr. Knight as he is planning to be in the Carribesn for a holiday in
we have

carried

on

February.

assist

in
of the cases reported from your Department, cases with
the syndrome of cannabis toxicity and/or cannabis psychosis. It may
provide him with the basic experience upon which to design a study
to resolve some of the discrepancies noted earlier. I am sending him a
copy or this letter, and will ask his to vrite to you directly.
seeing

some

I am'writing to ask vhether

Many

you could

thanks for your assistance, and

my

him

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>May

8, 196‘

Dr. Carl F. Boovor
Aooiotunt Diroctor

Clinical Invootigotion
Echoil Laboratorioo, Ina.
Coup

rott

Hill

Road

Wishington, PI.

Dear Dr. Beaver:

I ﬁll

plooood to how. an opportunity to moot you in Philadolphia.
Loo Angolan. Considoring tho anchor of fricado that
I no. on both ooooto, I can now undototand.why the stock of major
air lino: has rioon to rapidly in tho past your!

tad again in

onrly clinical drug evaluation unit of this instituto will be
ootdhliohod within the our: fan aunts, and on would like to considot on initial study with triflupuridol in a group of chronic
Ichixophronico. A: I iodioatod to you, we or. now in the midnt
of o long torn study of those schizophrenic potionto who have
failed to roopond to o vurioty of therapies. Nb aro in the midst
of anothor payohottopio compound, butaooraxino, and should like
to oodortako In invootigotion with on. of the hntyrophononco.
Ibllowing the reports of Dr. Lebanon and others, I should like to
iovuotigoto the clinical effioncy of trifluperidol in from twolvo
to county patient: at multiple dosage lovols. Vb or. soot intorI3t~
ad in ovnlulting tho change: in clinical lynptonutology, and anooo«
lazing those with chungoc in tho oleotrooncophnlogrnn. Rh nose, of
courno, undertnko a varioty of other liberatoty lawn-tigntiono both
to couplonoot our studio: ﬁnd to protect our potionto.

Tho

l

on onclosing

I

completed

for: In

1573.

would be pleased to hut. you visit St. Louis to discus: thin pro~
grow in grotto: dotoil. On such occoaioo, I think you should again
who in tho dirootor of on: BBC laboratorioo, and
one: Dr.
Dr. Don, who hon rooontly joined no staff and will ho rntoonniblo

I

ltil.

for the clinical observations.

�Dr. Baavnr
Page Th»

Th undqrcak- Iueh a study. I would bu grateful if "@3311 Laboratorios
uuuld aonsidcr a coneanatant grant in aid, cc hulp éafrly can. of the
cxpenscu of our ldborutertnn. especially that. of the coat: of electran

cucnphslogrnyhy.

Thank yuu vary much

for yang intotust.
Sinceruly yours,

v

w...

..

Kn: Fink. 1M).

Diructor

my—MW'“-

1013!.
Rue.
Wm‘mm

.

9.3. In your inscription oi trifluperidol. on page 5, you downribc
a taper: by nulny and Picket. Eb wuuld appreciucc a eopy of
this raport.
.

�</text>
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                    <text>H81 25. 1965

Dr. Carl F. Bauvcr

Asllataut Dittctor
Clinical Invnltigation
McKnil Laboratories, Inc.
Camp H111

Road

For: Bishtnxton, P¢. 19034
boar Dr. Botvor:

utru platted to racctv. yam: lettcr of May 19,
it
turntng horawith the Suntannnt of turnstigator ts

and

I an

ra—

toqunnted.

budgstary cuppart of those studico is provided through ch.
Paychistrie actuarch loundnttan of Hisaonrl, and all check:
nhould ha and: out to that organization. Thu addrals 1n the
can: as the Hangout! Institutu of Psychiatry.

Tho

Sinatraly yours,

”I: rink .
Director

Mr/jb
Baa.

MOD 0

�</text>
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                    <text>June 17, 1964

"'Tm—F‘me

.

Dr. Carl F. Beaver

Assistant Dirontor
Clinical Investigation
McNeil Laboratories, Inc.
Camp Hill Road
Fort Wishington. Pa.

Dost Dr. Bosvsr:
Mr. Daniel Gents! visited with as today and I was pleased to
hsvn an opportunity to most him. Our pnogrsn for the study
of trifluperidol has progrssssd rsthsr well, and we are now
selecting patients who will be admitted to the Institute dnr~
ing the next few socks for this study. We hays, during the
past two weeks. appointed a number of people to participate

in this 2.0.9.3.0. program.

In your recent letter. you note that you has: initiated s
check request in tho amount of $1,570.00 payable to the
Psychiatric Essssrch Foundstion of Missouri. I would be

grateful. if the letter of transmittal would indicate that
this sum represents a favorshls response to our request for
support of our program. and that the money is appropriated
for "the general corporsts purposes of tho Foundation." I
an taking tho liberty of enclosing a form draft copy of s
lsttsr which is most satisfactory to the Foundation.
I would bs'grststul if it is possible for you to transmit
this and any subsequent amount with a similar letter.

Thank you

for your cooperation.
Sincerely yours.
Ms: Fink. M. D.

Director

HP/jb
Boo.

�is pleased to

Tbs

approve your request for a great in aid in the sum

of

8

for the general corporate purposes of

tha Psychiatric Research Foundation of Kiasouri.
01'!

...for

the rcaaurch and training programs of the

Psychiatric Research Foundation of Missouri.

�</text>
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                    <text>March

ll,

1983

Aaron T. Beck, MB.
406 Wynmere Road
Wynnewood, PA 19096
Dear Aaron,

Congratulations, again,
PsychopathologicalAssociation.

on

your

award

from

the

American

As I listened to your presentation, and the sense of the sessions enquiring
into the relations between drug therapy and psychotherapy, I was mindful of the
linguistic studies of the 1950‘s. The work of Rioch, Weinstein and Kahn, and Sapir,
sought to define behavioral change in measures of language. Many authors (Jaﬁe,
Birdwhistle, Strupp, among others) went into microlingusitics, speech pauses, typetoken-ratios and mechanical aspects of speech, but others sought to measure
definable entities like first and third person speech, denial, minimization, and
displacement. I found these ideas useful as I sought to define the behavioral
changes of patients undergoing ECT and drug therapies. In one study, Jaffe (l)
sought to define the type of psychotherapy that would be enhanced during ECT. I
reviewed that work in a presentation to the APPA in 1974 (2). I commend it, and
the interesting work of Weinstein and Kahn (3), as complements to your present
thoughts.
My regards.

Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry
(1)

Jaﬁe, 3. An objective study of communication in psychiatric interviews.
3, Hillside Hosp. g: 207-216, 1957.
Jaﬁe, 3., Esecover, H., Kahn, R.L. and Fink,
psychotherapeutic transactions by altered brain
Psychothe ._l_53 46—55, 1961.

M.

Modification of

function. 5.3} g.

(2)

Fink, M. Brain function, verbal behavior, and psychotherapy. Comprehens.
Psychia . 12: 257-266, 19701.

(3)

Weinstein, E.A. and Kahn, R.L. Denial 91 Illness. C. C Thomas,
Springfield, 111., 1955.

v!

,1,
u

rm,»

um;

rmsw

“nun-warm“

'H.w-.mx.-nwz.-m

�</text>
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                    <text>Department of Psychiatry

September 3, 1972
Mr.
CRC

Jerry Becker,

Manager

Press Division

Chemical Rubber Company

Cleveland, Ohioo
Dear Mr. Becker,

Last spring, you wrote regarding the publication of a
volume on the narcotic antagonists. At that time, I was in transition
to a new university and was unable to see how I could find the time to
undertake such a mission.
Since then, I have reviewed much of the literature on the
and it may be possible to put such a volume
together during the next 6 months.

narcotic antagonists,

If this is still of interest, please write again.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Jamm
I». Peter

G. S.

31, 1967

Beckett

951 East Lafayette
Detroit 7 , Michigan

Dear Peter,
Enclosed

Computer

is a preliminary draft of the report "Digital
£156

for Psydzoplmmaoology," which will
Amlysis of
1967
the
mating of the APA in Detroit.
at

be presented

I look forward to your discussion.

My

best regards.

Sincerely yours ,
Fink, 14.15.
Professor of Psychiatry

Max

MFﬂcp

�</text>
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                    <text>ra

2w:

,

November 19, 1969

Dr. Gerald L. Beckloff
Director of Clinical Phxrmacology
Marion Laboratories
10236 Bunker Ridge Road
Kansas City, Missouri 64137

Dear Dr. Beckloff:
We have reviewed the data of our pyrovalerona study
(your 010—022) in response to your letter of Havember 11.
We

carried out

one placebo.

our report.

20

trials

The placebo
The ages and

The remaining

with pyrovalerone and
omitted in Table 1 of
dates of testing are attached.
—

19

trial is

supplies have been destroyed.
Eincecely yours,
H.(.
Professor of Psychiatry

Hax Fink,

�,.

7-

“ya—“.7..." ..

..—mn

”3.7

”Kw—s

w.

November 19. 1969

Pyrovalorone

—

BEG

Study

Date of Experiments

“Age

(all

P.I.

25

4/8

M.I.

21

4/11, 4/24

5.}{.

23

4/18

R.L.

22

5/1

F{'F.

22

5/2, 5/27

26

5/9

22

5/9

25

5/26

6/3, 6/13

$%.L.

22

R.G.

22

6/.3

B.G.

22

6/25

J.B.

20

6/26

M.D.

21

7/11, 8/6

W.C.

21

7/17, 7/24

-

6969)

�</text>
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                    <text>April 22, 1953

Beckman

Instruments, Inc.

Scientific and Process
Instruments Division

Fullerton , California
Gentlemen:

Will you please send us as quickly as possible
Data File LR—38—163 regarding the new Beckman linear
and log recorder. Thank you.
Sincerely yours ,
Max
MF :aw

arr-g

.A.

”ham-m

,wvwwwﬁ

A

.-

Fink,

Director

M; D.

�</text>
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                    <text>7433-03683
21 January 1974

Graduate School Admissions
Box 1504A, Yale Station
New

Haven, Connecticut 06520

Gentlemen:

Re:

Steve Kahn

I am pleased to submit the following information regarding
association with Mr. Steve Kahn, who is applying for adnis—
aion to your graduate school to continue his studies in psychology.
I have known Mr. Kahn for over a year, first in his role as a
volunteer in our study programs and, since July 1, 1973, as a
research assistant. While a student at this university, he volun-

my

teered to participate in neurophysiological and behavioral experi—
in this laboratory. we found him a cooperative, bright, and
reliable participant, and when we sought an additional research
assistant, we accepted his application.

ments

Since July he has learned to record EEG and to obtain behavioral date from our ongoing experiments, in which volunteers
receive psychoactive drugs and are observed for periods up to
four hours following such administration. In addition, he has
operated the IBM 1800 computer system, including the EEG data
reduction and statistical analysis. He has carried out multi~

variate statistics

and

interpreted the results

up to

writing

a completely documented report. At the and of six months of
tutelage, I was pleased to recommend him for a promotion and

raise.

Mr. Kshn

is

an

intelligent, dependable,

and cooperative young

accepts responsibility well. I believe he is qualified
for graduate study in psychology, and he has demonstrated his in~
terast by his work in this laboratory. I recommend him for the
program which he has applied for without reservation.

man who

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

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