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                    <text>January l5, 1968
Dr. Ralph Jacobson.

w‘»

Associate Medical Director
Endo Laboratories
1000 Stewart
Garden City. New York ll533

“

av:

v"

w

Dear Dr. Jacobson:

1.?

Lawn-m7.“

Enclosed are two copies of the prelﬁminary report "Naloxone
(N-Allylnoroxymorphone) in Opiate Dependence."

inquire as to the present status of the production
of naloxone for further clinical trials?
May I

Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max
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                    <text>May

8, 1968

Dr. Ralph Jacobean
Endo

Laboratories

1000 Stewart Avenue
Garden City, New York 11533

Dear Dr. Jacobean:
Enclosed

is a

capy of the report which we recently

read both in Tarragona and in Atlantic City. I look
forward to receiving supplies of naloxone in the smmer
and hope that we can continue our studies.
My

best regards .
Sincerely yours ,
Fink,
m
Professor of Psychiatry
MOD.

MF:kp

,
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                    <text>Jul y 31. l968
Dr. Ralph Jacobson
Endo
lOOO

Laboratories
Stewart

City,

Garden

New

York

Dear Dr. Jacobsen:
Mr. Kline

delivered the naloxone -

many

thanks.

Dr. Zeks and I are discussing the details of our protocol
and we anticipate the need for placebo tablets at sometime
during the investigation of each subject. would it be
possible for you to supply us with lOOO identically scored

placebo

tablets.

Many

thanks!

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>w."-

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mne-

Mr. R.

J. Gradwell

National Institute of Mental Health
5454 Wisconsin lvenue
Chevy Chase , Maryland

Re: Contract HSM—42-70-98

Dear Mr. Gradwell,

Enclosed

is

a signed

DREW

certificate involving

subjects. as requested in your letter of June 22.
In reading

this letter

human

which seems to follow a standard

prior approval for foreign travel must be obtained. It in my
understanding that this contract, in justifying foreign travel as
essential to the purposes of the project, yields 'prior approval'.
I am leaving for Athens on August 4 to negotiate the subcontract, and
if this interpretation is incorrect, please advise.
form,

we"-

‘_

May I also request your secretary to send us blank
copies of Form 1034, 'Public Voucher for Purchase and Services other
than Personal'?

.,.,V

Thank you

”.77",

for your assistance in negotiating this contract.

«um-7...,”

Sincerely yours,
.z‘K’UI-'l"'g‘|nn"“z‘n-

"sun-um

Max

mf/

Fink ,

31. D I

”ms.

v-u

#‘U:WWW"W(AW

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                    <text>A.

.
t

WW,

n...“

“F...

July 3, 1970
Dr. Ralph Jacobsen

Endo

Laboratories

Garden City, New York
Dear Ralph,
Thank you

for the corrections to the

summary

of the

meeting. I will make the changes, and I am pleased to
the
that
summary has been accepted for publication in Science.

June

4

we

tell

you

have had an opportunity to discuss the problem of continuing

our studies of oral naloxone. Aware that our request for additional
supplies for oral trials remains unfulfilled, we have requested support
from the New York State Narcotic Addiction Control Commission for our
independent purchase of naloxone from any available source.

It is my understanding that Mallinckrodt Chemical Co. is
the principal U.S. source of the compound. I have written to the President
of that company, enquiring as to the possibility of their supplying
naloxone for our use.
I

would appreciate ypun cooperation in

this request.

It would also be helpful if you could tell
potential sources of supplies of naloxone.
Many

us of other

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>May

18, 1971

Dr. Ralph Jacobson

Laboratories
Stewart
Garden City, New York

Endo
1000

Dear Ralph,

Enclosed is a copy of our proposed study of naloxone, as
submitted to our research committee. I would appreciate any
criticisms or suggestions to improve the study.
make

Our thanks, once again,

this study possible.

for your interest

and

efforts to

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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Ralph Jecobeen, M.D.

Deputy Medical Director
Endo

Laboratories, Inc.

1000 Stewart Avenue, 3
Garden City, New York 11530

Dear Ralph,

thanks for your contribution to the programs of the
College. We will use the grant to buy some equipment which
we sorely need.
Mnny

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:jb

�</text>
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                    <text>'mv’tryu;

September 10, 1971
Dr. Ralph Jacobsen
Endo

Laboratories

Garden City,

New

York

Dear Ralph,

I

subjects

am pleased to enclose
who received naloxone

the case summaries of nine

in oral doses above

200 mg/day,

received doses to 3,000 mg/day. We
including subjects
have requested the complete hematologic profiles obtained by
Dr. Lerner and his staff, and these are included.
who

present study program, using naloxone concentrate,
is underway. Dr. Zaks has screened a number of applicants, and
these are now in their periods of detoxification and medical
examinations.
The

pleasure to see you in Washington last week,
I look forward to the development of both EN 1639—A and
naloxone pamoate, as both compounds seem to hold much promise for
the eventual solution of the problem of opiate dependence, not
only in our soldiers in Southeast Asia, but the many patients
in our ghettos as well.
and

It

was a

Thank you, again,

for your support

and enthusiasm.

Sincerely yours,

‘
.,

.
221-,

.£~mvﬂwmnﬂ‘mn-vr:

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>November 3, 1969

Dr. Ralph Jacobson
ENDO

1000

Laboratories
Stewart Avenue

Garden

City,

New

York 11530

Dear Ralph,

to confirm the telephone conversation of October 27.
You will be pleased to know that Dr. Zaks has been successful in
extending the duration of antagonism to heroin by naloxone. In
a subject receiving 3 Gus/day, 26 mg heroin, 25 hours after the
previous dose was experienced as a "blank", the subject exhibited
neither behavioral, physiological or EEG signs of heroin administration.
I wish

Dr. Zaks was planning

to retest the subject at

50 and

perhaps at 75 mg (at 24 hours). This experience is very
encouraging and I have asked Arthur to send you a detailed
summary and a plan for continued study as soon as he completed

the present series of experiments.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>_

:

~

wwwwxw «n-r- A4

nuw

n—ww

Haw:

-v

w

1’f'I-W-'F‘I‘Tw_ﬂ”

smug-«an.

:.

~,

5‘.

,

-w "l ”.1.
,-.

:..—.;.:v—c-.~.~

vs..-“

A”.

u

,.., ,h.,.,w.r_c.,,.,,,,.,..

1.

7.7M

.4-

n.” “H“,

_,__

.V

Aprll 23, l970
_
A

l
I,
-

A

,..l-.v

—
—-.

Dr. Ralph Jacobson

Endo

IQOO

Laboratorlss

Sfowarf

Garden

Clly,

New

York ll530

mﬁ‘a-n-

‘_-.,mm—.-,;_.Wv

/v“\

‘C'IQ‘W:'-twrw"“-\vri

Door Ralph,
Some months ago, we dlscussod the posslblllly of a broad
cllnlcal lrlal of oral naloxono ln slnqle large dally doses
(2.4 lo 3.0 Gms) ln oplafs dependenf subjects. You wlll recall
That no roporfed our obsorvallon lhal dolly doses of l.2 and 2.0

falled To profecl our subjects beyond l8 hours lo 25 mg
lnfravonous heroln, bu? the? 2.4 and 3.0 Gms wore sffscflvo for

Gms

more Than 24 hours.

Upon your reassurance Thal Mr. Bovld Kloln, your vlcs~
prosldonl, had personally rooussfsd fhs suppllos be made avollable,
we rolurnod our romslnlng naloxone, so Thaf The larger lablols
could be prepared.

Durlng The pas? 6 months us have received monfhly roassurances
That naloxono would shorfly be avallablo. ln your message lasl
week, you slated fhal prlor calls on your suppllos. plus dlfflculflos
a? Molllncrodf Chomlcsl, plus expense and olher»oommllfmsn+s a? Endo,
made if unllkoly lhaf naloxono would be avsllablo for cllnlcal lrlals
before Soplember of The oarllosl, and roallsflcally, probably no?
unlll +he end of rho yssr.
Mosnwhllo, lho publlc press lndlcalss (from your release?)
an NBA for Narcan ls lmmlnonf ”wllh cllnlcal ovaluollon
expoclod To be complsled wlfhln 6 lo 8 monfhs on Tho drug's efflcacy
ln horoln and oplofo dopondonoo.“ Tns roporf makes erroneous
references lo the work In fhls laborafory, and oven allowlng for
roporfsrlal errors, l am concerned +ha+ l may be mlsquofsd - not
only #0 The press, but To rogulafory agonclos as woll.

lhaf

Our flndlngs wlfh oral naloxono ln 7 cases have been publlshed.
flndlngs wllh dosages to 3.0 Grams/day are confldenllal
and were reported lo you To supporf our collaboraflon, and were not

Our subsoquenf

avallable for

FDA

submlsslon or publlc reporllng.

V

.

,

,

‘

,ﬂ

V

_

,

�Fwwww

om

r
”aw-H

Dr. Jacobson

-2-

April 23, l970

»

A-vr

V.-—..n—P—..—«&gt;—-

i hope The misquoTaTion did noT
resulT from an Endo reloasa,
buT did come from an enThusiasTic roporTer's misquoToTion of
our
preliminary reporTs To The STaTo NarcoTlc AddlcTion ConTroi Commission.

‘i am wrlTing Today

for

The following

reasons:

i. To record my undorsTandlng of your Telephone call
oral naloxone ls noT available for clinical Trial in opiaTe dopendonco in daily doses of 2.4 To 3.0 Grams; and ThaT The earliesT
daTo for such supplies may be SopTombor i970.
ThaT

us during

2.

To requesT ThaT The supplies of naioxono, roTurnod by
The winTor, be made available To us once again. As
you

recall, we have boon able To adminisTer cyciazocino very rapidly,
proTochnq our subjecTs againsT The agonisTic offocTs of cyclazocine
by oral nnloxono. We have found ThoT 300 mg naloxone, 3 To 4 Times
a day for 3~5 days, is useful in cyciazocine lnducTion. We wish To
TosT This observaTion in 50 consecufivo addlcTs, and
require 4.0 Gms/
subjocT or 200 Ems. our presenT supplies are almosT exhausTod.
we would like To carry ouT This sTudy as
rapidly as posslbie.
Can you reTurn 209 Gms naloxono in 303 mg (or lOO mo) TablaTs To
us wlThln a monTh?

3. To suggosT ThaT we adhoro To our undersTandlng, ThaT
oTaTemenTs regarding our work, be made by prior iniTial consonT
You will recall ThaT our College has subscribed To such
an
undersTondlng. The enclosed reporT may roilecT a TransienT lapse
of ThoT undersTanding, and i TrusT does noT soT a procedonT nor docs
lT represonT a change in our undersTondlno. 0r doos lT?

public
only.

Ha.

ww-m‘rv—

layover»

&lt;-

w"

we“

u»

man-e:

r-c

.w;7~.w-

incidonTolly, Tho reporT of progress in a long acTing naloxone
prooaraTlon was encouraging. You will recall, however, ThaT The
figures you ouoTed, regarding The amounTs of naloxone
To onTagonlzo heroin in our subJeCTs, seamed ouT of Thenecessary
range of
our experience. i suggosT ThoT Those figures require revlow,
parTlcularly if The pharmacouTlcai chemisTs oro using Them as
bonchmarks in Their work.

will call your office in lo days, if i have noT heard sooner,
regarding your release of 200 Grams naloxono for a cyclazoclne-naloxone
i

sTudy.

Sincerely yours,

yruvap',"-‘WL

Max

Fink,

M.D.

Professor of PsychlaTry
MF:kp
GUC.

�</text>
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528 Harm Ridge Road
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93111th

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mm.Simly'yoxms,
Max

Pink,

Md)".

M

Professor of Psychiatry

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Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Chicago,
Dear

Illinois

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community - based
operation. Your presentation convinced me and I have written
a memorandum to Al suggesting we examine such a program seriously.

possibility of studies of

acting methadone
to participate in the
To carry out such a
with
we
Paul.
of
discussed
study
type
IND
and eliciting the
of
the
an
project may require
filing
of
manufacturer
the
for
continuing supplies. I
support
would be pleased to help in any way that I can.
The

is impressive

:.—mmnwzrw—V

Good

a long

and I would be pleased

luck in your program.

My

best regards.

rr'

Sincerely yours.

‘mWa

:4”-

1-:

FW‘FJ’V

Max

Fink,

M.D.

'

Professor of Psychiatry

MFtkp

,

‘WCW'V’W‘NWXDH

�</text>
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                    <text>.ﬁwnv—nwvw

,,

ry-w—

«n

0:7,":

--~

\r

“”me

WV. "thaw.“

s.7_

“—v-w-N‘rwi1w'rr .

uv'.»y—

n

-,

....-

,-

r

.q—,

Hr

,

\-_

“ﬂaw-“aw...

,. .,,.-g.svwr~-.—v-

September 3, l968

Jaffe

Dr. Jerome

Department of Psychiatry

University of Chicago School of Medicine

Illinois

Chicago.
Dear

Jerry,

After reading your reports and hearing your presentation
in Portland, I am impressed that methadone maintenance provides
an effective model. Especially, when presented in the storefront approach. As I mentioned, our rehabilitation staff have
been encouraging us to undertake such a community ~ based

operation.

Your

a memorandum

The

to

and I have written
suggesting we examine such a program seriously.

presentation convinced

Al

possibility of studies of

is impressive

type of study

me

acting methadone
to participate in the

a long

and I would be pleased

we discussed with Paul. To carry out such a
require the filing of an IND and eliciting the
support of the manufacturer for continuing supplies. I
would be pleased to help in any way that I can.

project

may

Good

luck in your program.

My

best regards.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

.

-

w-wn

�</text>
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                    <text>July 22,
Dr. Jerome H.

1970

Jaffe

Department of Psychiatry

University of Chicago
950 East 59th

Chicago,
Dear

Street

Illinois

60637

Jerry,

Enclosed is our check as reimbursement for expenses for
the June 4 meeting on narcotic antagonists. I very much
appreciate your participating.
You know

that the

published in Science.

summary

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a

pleasant

summer.

Sincerely yours,
Max

Fink,

35.2).

Professor of Psychiatry

HF:kt
enc.

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                    <text>June 13, 1971
Dr. Jerome

Jaffe

Department of Psychiatry

University of Chicago
Chicago,

Illinois

Jerry,

Dear

The preliminary announcement of your appointment by the
President to lead the national effort against drug abuse was most
welcome here. I hope the appointment is made, and I wish you all
success. The undertaking is a great one and I am confident the nation
will follow your leadership willingly.

Since the reports in the New York Times last month of the
high rate of opiate use in our troops in Southeast Asia, I have become
additionally concerned about this horrendous aspect of this tragic war.
In considering the alternatives, I concluded that our clinical experience
with the antagonists (much of it unpublished) warranted some suggestions
which I shared with those authorities I could reach in Washington. I
write new in the hope that our experience may complement and re-enforce
your suggestions and recommendations.
aware

I consulting with the V.A. leaders in Washington, I became
were being entertained to rapidly return large numbers

thht pland

of addicted servicemen to their home communities, particularly to the
V.A. ceneters, for treatment programs focussed on methadone maintenance.
Such a rapid dispersion of the addicted drug users would be a tragic
error, for the V.A. centers are ill-equipped at present to care for
these men, and the users would provide multiple foci for local drug
use and experimentation as well as connections to enhance a drug traffic.
Such a course, based on dispersion, is the worst possible solution,
to homes
for
will return men who are unprepared for community

it

life,

without jobs and with inadequate counselling, and encourage the Spread
of addiction.

Every effort should be made to identify, detoxify and treat
in Asia, before they return home. One interesting suggestion
is to return the men to the States in slow ships, thus providing at
least 3—4 weeks of isolation, group therapy, counselling, and medication.

the

men

�“I1!-

new

..

Fun-["W—r

m

..
rmm

,v-w-u—m

m

Jaffe

Dr. Jerome

................ ...................June 13,
2

While I know every
and

traffic, educate the men,
tests, we would encourage

effort will

be made to

1971

restrict the

drug

identify users by urine and nalorphine
some specific applications of our esperience

with the antagonists. It now seems possible to provide prophylactic
programs, similar to the use of atabrine for malaria in an earlier war.
Opiate sependence has many of the characteristics of a contagious
disease, and I believe the daily administration of cyclazocine
would serve the same purpose today. Surely, id drug use is as widespread at the Times has reported, then an eXperiment in a small segment
of the 330,000 man army would be Iarranted.
Your experience with cyclazocine led to widespread
and in our early studies we confirmed your data.
The effects were exaggerated by the dosage schedules we then used. Since
January, 1970, we have inducted all our patients to 4 mg. cyclazocine
in 4 days with minimal discomfort, surely no greater than our patients

secondary

effects,

begin treatment with imipramine. For prophylaxis, 1—2
mg b.i.d.) should serve as an adequate deterrent.
The administration of a tablet twice a day at mealtime should serve
our purposes.
experience

who

each day (0.5-1.0

mg

-

have also discharged 6 patients from all care after 1.5 to
years on cyclazocine. These men remain drug-free, without 'craving'
We

4

after

3-9 months on no medication. Such a limited experience is
and not decisive, but sufficient to encourage further
trials. Surely, some military patients could be randomly assigned to
the antagonists, and were this experiment done carefully, an adequate
sample could be provided in a very short time. The men would have
similar histories of drug use, conditions of treatment and living,
etc. to those assigned to other regimens. Such an experiment would

interesting

answer many questions not only for the military, but for the nation as

well.

,
u...

In our discussions, and in the press, you have repeatedly
suggested that with the limited funds at your disposal in Illinois,
methadone was the treatment of choice. I agreed then, and I agree
today, that methadone provides the best answer for today. With
the crisin in Viet-Nam and the availability of funds from the military,
the V.A., and the P.H.S., surely the extensive clinical trials we
discussed should be undertaken as a logical back~up to the other programs

which you

will encourage.

For more than two years, I have supported and encoyraged
studies of the antagonists. As a national leader, I know you
will accept the repponsibility of leading the effort without the
parochialism so sadly evinced during the past few years by all of us.
I am delighted with your appointment, and I am encouraged that now I
can again turn my attentions to my laboratory studies.
expanded

With

all best

wishes for your personal success, I remain,
Most
Max

sincerely yours,
Fink,

M.D.

Professor of Psychiatry

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                    <text>r

v

-

W' “'~"WIW'.—wmrrmwprwn

.
v-‘WI u r‘:',v
n'vwvww‘ww' use... Irv-”lav.
.V

7

a“

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.

V

.

.

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u

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e

n.

u

T. n

.. n . v.7,

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.
.14.:v"

.w-

July 23, 1971

"v“,

r

:rrv-r-wwr-v

-

vvw:

Dr. Jerome

Jaffe

The White House

Washington, D.C.

.J"

Dear
i
'

A

.

Jerry,

John Kramer attended the Aberdeen meetings and during
our discussions requested some information as to the present status
of the development of a long acting silastic-implant for
naloxone or cyclazocine. I am enclosing a progress report on
the present contract, between the College and the Food and
Drug Research Laboratories. The contract ends on October 31,
and we have not been successful in ob—aining continuing support
from the state of New York.
My

best wishes for your success.
Sincerely yours,

E

Max

Fink, M.D.

Professor of Psychiatry
'I—‘—"v"

mf/
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...,.v

“Ir-,-

—~

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V

,1..-

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var-w»- 0.-., u

.

.w

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                    <text>mar—VW'WRIW“

July 2,
Dr. Jerome

3-}.

1971

Jaffe

Special Counsultent
to the President

The White House

Hashington, B.C.
Dear

will

Jerry,
The grapevine has you

be

off for

Viet~Nam, an&amp; I

trust

your

trip

helpful in clarifying the facts of drug abuse along our

servicemen and

their dependents.

called earlier this

week, and I freely shared our data
£150 sent him a copy of the program of the looting on
narcotic antagonists to be held in Aberdeen, July 12-13, and a copy
of a small project to get studies of M-soso off the ground.
Roger

with him.

1

It is apparent that neither

NIHH, BEBE, ”AS/NRC,

nor industry

have provided the leadership to develop the antagonists. I believe
the appointment of either I committee or an ”office* for this
dovelopment would be a necessary first step. New York City mas
established such a committee but included no one with dedication

or interest and
A.

it is

ineffectual.

In answer to your questions, the projects that are important
(1) Testing cyclazocine prophylaxis in Viet-Ncm, using

available oral doses of

2~4

ng/day,

coubined with.naloxonc during the
(2)

a

rapid induction schedule,

first

Develop u long acting

week.

antagonist.

(a) Contracts for trials with naloxone, using
such methods as depotaoil, silastic, plastic film;

this

(b)

Change import quotas fOr

(c)

Trials for

thebeine and import

other raw materials for naloxone; and, establish
supply of naloxone for clinical research.
and

u long

an adequate

acting cyclazocine.

�—~e:an‘-m-MWWW

Jaffe

Dr.

-2-

July 2,

1971

unn-

"
‘vvf

iv

Test and establish the pharmacology, clinical toxicology

(3)

~—

clinical trials with

and

useful, introduce

it

M—SOSO

and

into trials of

EN

If either

1639A.

compound

a long acting formulation.

is

(4) Clinical trials of cyclarocine or naloxone in direct
comparison with methadone or l—alpha~acetylmethadol.
B.

The

"guesstimate" costs for the projects,

on a

"crash" basis:

(I) frophyl§§i§_- for consulting expenses US-VietNam, 4—6
$10,000; local military costs; supplies to be defined
staff
by Sterling~Winthr0p based on size of study.
members

(2)

—

Long

acting development

(lst year).

$800,000 (4 contracts

Naloxone

Thebaine and naloxone supplies $250,000
Cyclazocine

status of

(3)

M—5050

Pharmacology

1639A,

but for

M-SOSO:

and

EN

Animal pharmacology

Clinical trials
Supplies

.m—

:

6

VA

(4)

clinics,

Clinical

600

added to present
C.

Role

If

1639.

I do

?

not

9

$200,000)

know

the

$42,000
120,000

50,000

Comparison Cyclazocine-Methadone:
$200,000 organization cost

patients, additional

VA

allocations of $400,000/unit.

for myself.
you

establish

a commission, I suggest you consider
F. Blane or K. W. Bentley
I would be pleased to be

J. Villareal, D. Jasinski, G.
(Great Britain), J. Woods and A. Kurland.

A.

Freedman,

a member or to chair

it.

I have been actively soliciting the cooperation from industry
a few years and now know many of the people who could be involved
in a long acting drug research program. If a committee were set up
and given the support its studies justified, the programs would be
successful in a reasonable time. They may require some special
regulations regarding financial rights to industry, however, and some
cooperation from BNDD.

for

,

�&lt;_:-v..-

"1"”

.

Dr.

Jaffe

-1-

July 2,

1971

Should you wish to undertake this program yourself, or have
Roger, John or someone else do it, I will make my files available
and introduce your appointee to the appropriate persons.

Incidentally, Villareal and Kosterlitz are chairing a symposium
the antagonists in Aberdeen, July 12~13 and you may wish to attend
or send someone. I sent Roger a copy of the program in case you had
not seen it.
on

Again,

my

best wishes for the rapid success of your mission.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Dscssbsr 3. 1971

Dr. Jerome K.

Jaffe

SADDA?

white house,
Washington, D.C.
Dear

Jerry:

Roger called me about the problems in obtaining supplies of
cannabis and opiates for research. Our difficulties are long standing,
and are of two kinds * "approval” by an FDA-NINE Connittee that has ar-

roasted the responsibility to review the specific content of the uses and
to which applicants for drugs are making of their requested supplies;

actual distribution difficulties.
Since 1968,

we

have had approval from 31MB,

BNDD,

H.Y.

States

College to study cannabis
3.1. City, and the appropriate committees of our from
scientific committees
and heroin in man. we also have fornal support
[psychopharnacology],
(N.Y. Stats ﬂacc~contracts since 1967; Nlﬁﬁ 13358
18172 [cannabis], and 19h76 [heroiu]l(
Yet, when we request supplies of cannabis, us are again asked
supplies
to submit formal proposals for committee review. Not only are
the Con—
of
the
prejudices
reduced
to
according
and
the
aaounts
delayed

their arbitary decisions. For exnittee, but our intent frustrated 21bydays
of marijuana use in man would

ample, in June we were told that
dsensd
not be allowed, but 7 days would be; and in September, the Committee
made
in
21 days allowable for all investigators. Such reviews are not
the
any other drug study we usually depend on the investigator to assess
the
by
risks and the needs of the study progrsn, and rsquirs monitoring
appropriate connittsss of his institution.
—

It is

ny

belief that the

Committee ought

to restrict

its

func~

tions to advising the Secretary of HEN about the distribution of those
drugs which are in very limited supply - to evaluate the priorities among
of the nation.
scientists who nay have special calls on limited assetsshould
be freely
the
distribution
ample
supply,
But where drugs are in
made to those scientists who have eat the standards of research and infor which drugs
stitutional monitoring approved for the specific studies
pious reaare requested. The assumption by the Committee, for whatever
to drug
deterrent
severe
is
a
of
proposals
the
content
sons, to critique
study.
and
fruitful
inhibited
and
both delays
research,

�Dr. Jerome K.

Jsffs

Deceabsr 3, 1971

Tho sscood issus is that of the supplies. Ones spprovsl is
tho
givsn,
suppliss srs distributsd in obtuse snd sxpsnsive ways, with
suppliss dslsysd and lost. On two occssions, horoin hss been sent through
the osils sod hsvs been lost. Prior to the roosnt sssusption of distribution by BRDD, ths drug was dalivsred by so sgsnt of tho Justice Departssnt sod whils it took months to obtain suppliss, thsss did svsntuslly
arrive. ﬂow, it tskss months to 3st sporovsls and suppliss come only
site: rspostod cslls.

Incidentally, so sro embarking on tbs spooisl study which you
othsrs hsvs rsqusstsd that of tho duration of action of ssloxons
pssosts. Us hsvs no hsroin on hsnd, sod dsspits roqussts since tho sod
of August, sad submission of tho oscssssry docuosnts, us will be forcsd
to carry out thsss ssssys with inputs substancss. Porhsps your attics
could call BNDD sod srrsnss for s ship-sot of 1 Grss for the iossdiste
uss, psoding tbs usual longthy procsss for 5 Grsoo?
and

—

Sincsrsly yours,
Pink, M.D.
Professor of Psychistry

Max

33:13

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                    <text>m

-

nu.—

~.

0‘ -m—v' n
.

r—-.wt n
....'WI aw‘ WV

v

n.

..., m

u :m.

m

7'“ ‘7

mummy-u.W..." “aw—9.,” 9, AM'“
,

_

,

«pun.

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..._._~~..... ,

we.

,,r~.r--.ww.,.-

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e

go-

,qrw..~_,.p
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twvwv
,.. .
.

,

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_....V

January 3, 1972

wwmlwu'r‘vav‘v-ww»

Jaffe

Dr. Jerome H.
SAODAP

u

n

‘wn‘

The White House

Washington, D.C.
v-wwnm

»«

.w-‘Fvw—

rrwW.

Deer

Jerry,

In an interesting discussion with Dr. Cameron of the W.H.O.
in Mexico City, I was alerted to the possibility that Paul Jannsen
may have some potent and long acting narcotic antagonists. I wrote
to Paul and his answer is enclosed.

I plan to be in Europe en route to Athens between January

W—

v

I'Wr'

awrwrmw-qw

20 and February 10, and

will visit Janeeen at that time.

staff to accompany
It may be helpful for a member of your
have
indeed
some interesting
does
Jenesen
event
the
that
in
for
,
leads, these should be evaluated independently of any evnluation I

me
"I'm-IT."

"Jim-w"

may

make.

mun-r

my

best regards for a successful

1972

I

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

_

awwm—m”

1'"

‘7
mm.

-‘m'ﬁ'ﬂimrgrr

mf/

P.S. I am also enclosing e copy 01 a letter from Professor R. Mechoulem
of the Hebrew University. A1 Freedman interested him in the problem
of a formulation of naloxone for delayed release, end we supplied
him with some naloxone. In the event that you have e list of
potential research laboratories for this program, you may wish
to include him.
P.P.S.

What

is the status of the animal toxicology for

M—SOSO

?

.

u

.

.n— u..._‘.__.

”—77--

_

�</text>
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                    <text>August 22, 1972
Dr. Jerome H.
SAODAP

Jaffe

The White House

Re; Diprenorphine (M-SOSO)

Washington, D.C.
Dear Dr.

Jaffe,

you know, we have undertaken the pharmacologic testing
of diprenorphine (M—SOSO) to comply with the interpreted regulations
of the FDA, to permit us to assess the clinical pharmacology of this
compound in opiate dependence. We have had some difficulty in obtaining supplies of diprenorphine sufficient for these toxicology studies,
but did receive, this week, 15 grams from Reckitt &amp; Colman-- sufficient
to complete the animal trials.
As

if the

These
compound

trials will be completed by the end
is 'safe', we will apply for an IND,

to undertake the clinical studies in February, 1973.

of the year, and
and should be ready

have been advised by Dr. G. Blane of Reckitt &amp; Colman
that future supplies will have to be obtained from Lederle Laboratories.
When we attempted to obtain some supplies from Lederle in May/June, we
were told that they were disinterested in such studies.
We

believe that the assessment of diprenorphine for opiate
health possibilities. Anticipating difficulty
in obtaining supplies in 1973, I am writing at this time to ask your
assistance and advice as to the best procedure we may follow, to
assure an initial supply of 15 grams for human studies. The availabilitt
of a supply of M-SOSO in February, 1973 will permit us to fulfill one
of the committments of the NIMH contract 42-72~207.
We

,3..-

w,

,.

arr

”my-n.-

dependence has public

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Ramsay,

NIMH

�</text>
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                    <text>October 5th, 1972

Jafte,

Dr. Jerome
SADDAP,

The White

Eonse,‘

washington, D.C.
Dear

Jerry,
I

am

enclosing two preprints of reports that
American Psychiatric Association.

submitted to the

The levcmethadyl

we

have

study confirms our previous study

that ofyour co-workers that the effective 72 hour dose
of levomethadyl is store 70 mg. we are impressed with
both the safety and efficacy of levomehhadyl and would like
to undertake a more extensive clinical trial. In calling
N.I.M.H. regarding additional supplies, I have been notified
that the supplies are restricted, and plans for an extended
clinical study are not an adequate Justification for the
release of the available supplies. I have also been told
that the restrictions in studies are based on presumed
FDA requirements for extended toxicology.
Are we, in fact,
from
restricted
extending a levomethadyl study to all the
patients at Metropolitan Hospital?
and

'

The second report demonstrates that cyclesocine can
be given in higher dosages with good tolerance develoyment

for agonistic effects.

this be confirmed,

delivery schedule.

we

initial heroin
ha

challenges suggest
hours,and should
will undertake a three times a week
Our

an entension of antagonism

to

more than

(These two studies were done at the
College and will continue at that unit).
Good

New

York Medical

luck in your efforts!
Sincerely yours,

Max

MF/ij
Enos.

Fink,

M.D.

�</text>
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                    <text>Havember 22nd, 1972

Jerome Jaffe, M.D.,
B.A.O.D.A.P.,
White House,

washington, 9.0.
Dear

or

Jerry,
Perhaps you should know about

methadone

delivery.

this extension

sincerely,

Fink, M.D.
Professor of Psychiatry
Mb:

rim/15

Ens.

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Ir.

Joseph Jaffo

722 N. 168th Street
New York 32,, New York

DearJoe:

I am delighted that our computer is now installed and while
the major effort of the unit is ducted to writ
program for

EEGmlyais,Ibelievetlummybemtim-t
take a look at new language 52mm.

.ssmrto

at last talkad. you mentioned that you man marking
on a amber of program. For those that am completed, is
When

it

possible to get a dismim of the prom, or Witﬁ up.»
that I can judge the applicability to your equipment and interest.

W

ImiosedyouMngtMAPA.butIhadtMoppor-tmitym

with Ir. Fade, and he was most pleased as
discuss the
having appointed you as Chairman of one of the mittees.

Helodcsfozwamtoalotofmrk.
My

best

mm.

Sincerely

was,

I‘m Pink’

M. D.

Director

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Dr. Joseph Jaffe
722 West 188th Street
New York 32, N. Y.
Boar Joe:

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                    <text>new 16, 1963
Dr.

Jmph Jeff»

New

York 32, lbw York

722 West 168th

Street

Dear Joe:

First, 19‘: m thank you for your hospitality during my newt
visit East. I am sorry I missed
the mitme meeting of the

Way.

v

Asyousuggasm, ImtaDr. Warmdlmmiwdamply
to come no the Sta . I would liké
very numb to consider his appointmnt for the Institute
shall
mat with maple at the miv'emity later on mis- week. and
In tha
mantim, I would be grateful if you would write me a letter of
which indicated his desire

‘

mcwmndatim specifying the contact you had with Dr. Harthler
and indicating your opinion as to his abilities.
I, also, very
much enjoyed mating Dr. Earns. He
as a bright.
m
sophisticated and capable scientist.

imam

My

best regards to Nam.

Simmly yours,
Max

Fink,

Dimctor

M.

D.

�</text>
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                    <text>April a,

Bx".

Jone

'

I lodc forward to dismisaing the pmblem of the Research Cumin“
of the Acadmy of Psymmlysia in has Angelica. It may be mom
helpful to call a mating at a Specific time (Friday awning?

Samay

vW-r‘t‘rw'

m-v

17'W‘“,"~'«rr

«Mu;

"—wv‘

)lfrawvaus‘ﬂvy

.‘vﬂLﬂ-ﬁ‘ﬁm‘w

afternoon?)

diamim of the

joinwaorme
Mseehwmnymoan
that you Want.

problem

"than I do, and
10. I shall
My
that yau are plamim to stay at
£91613! 6
be
wmld
7.
the
In
event
that
leave
abmt
you
or
probably
would
enci
be
of
delighted
befam
ta
week,
the
I
leave
the
willing to
have you stop by in St. Wis on yam way hum. We will meet you at
the airport and take cam of all the amenities.
Your

My

letter indicates that ya; have greater patieme
meetings until
the

best regards .
81.11022me yours“,

Pink
m
Director

5 M n D".

,wm

‘—".‘"‘-rrr-"—J‘-B_I.

Imtitute

N Jam

7,-

'gv,q

Jaffe

The Hi
‘A. Waite
12 East 86th Street
M‘Ymk, Nan York

196k

ﬁfljb

�</text>
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                    <text>Jmtuzy 29.

1965

Joseph Juffe, M.D., Director
Resend) Depar'tnmt

me William Alunson White Irutitute
of Psychiatry, Psydwunalysis, and Psychology
20 West Nth Street
New

York,

New

York

10023

Dear Joe and Stanley,

It is my impression that the Clinical Cosmittee is interested
in supporting process studies of Ins .D. It is a problem, however,
as to whether they will feel ocmpetmt to evaluate as technical
a proposal as yours The chief enabling blocks, as descriMd

on the phone,

at}:

the suggested measures relevant and capable of
reflectingﬂmgesinbehuviwunduttitudeusinﬂumoedbyL.S.D?
to

1.

Are

2.

Axe

Mt

the statistical tedmiques sufficiently defined
emulate tests with small embers of subjects (1. e.

the pmblen of high interrelatims of mpeuted measures
subjects)?
3. Aggmoizenent ’of the investigator, and fees
Role

same

in the

instmctim of the patients.
of thempy eveluutim (outcome) memes in such

p mposed venture, defined in the
'4.

in

omplex procedure, (21 session, long term therapy subjects,
etc.). with the recommmdution either that therapy evaluation
a.

B’deleted or made

more

detailed and explicit.

.

If the staff members (Dr's. Levine, Wsskw, et el.) made
other suggestions, I would deem them helpful and would
suggest incorporating them with the protocol wherever prectioable 'und finmoielly feasible.

I

um

leaving the

mittee and will probably not per--

project then these prelimixury' 'mudings" and my ad hoe
advice. If you believe I can be of any useistmoe
study, please feel free to cell on me, as I believe it to be
an inportent application of psycholinguistic theories. If any
visit to New York would be helpful, I an suns the University

“1m

�will permit m to leave for a reasonable period, prova.'ded
funds could be made available for travel ($130) , maintenance
(MS/day) and consultant fees ($150/day). If this interests
you, my om'riculum vitae is enclosed for your use.
Sincerely yours ,
Max

MF'jm

Pink, H.D.

Professor of Psychiatry

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                    <text>robruary 12,

1965

Joseph 1.110. H.D.. Dtrcator

inlcareh annrtnnn:
The "1111:: Alannan Whit. Institutc

of Paychiatry, Plyahouaalylin. and Ptycholoxy
20 Want

7‘th

Riv York.

strtat

Haw

lbtk

10023

Dear Jon:

I an planning to can: to Run York ﬂIIt Thurud&amp;y for the Annricln
Ptychopatholoatcnl niacings not: Friday and Saturday. Phbtuary 19~20.
I

at th; Pork~8hcraten Thursday evuninz giant 9:00 p.n.
I would 11k. to bring tha taé.s with an and our dgta shnats and
spend soul tilc with you Friday attnrnoon. If this 13 unluitablc,
I vould 11k. to attend tho matting Slturdqy morning. dad can be
frag Sacutdsy aftnrnoon. Can you and Stan set aside sous till?
V111 bu

Sinatraly yours,

Hrs:-

ﬂak, rm.
m
Protansor of Ptychiatry

�</text>
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                    <text>Herch 8, 1965

Dr. Joseph

Jeffe,

K.D.

Director of Roeeetch
The Willien Aleneon white

Institute of

Psychietry, Psychosnelysis
20 west 74th Street
New

York. new York

end Psychology

10023

Deer Joe:

s greet deal of interest.
I have pointed
of
merits
the
providing teped sessions.
potentiel
out to my essocistes
hewe
we
recommendations,
investigated the tepe
Following your
machine market end the most teesoeshle reeonnendetion is that we
buy e Roberts—1630 instrueeot. I visited the locsl desler. end have
made e slsll tepe using the two microphones. I en sending this
tepe to you. I would be sreteful if one of your essistsnts would
put this on AYTA, end check if this recording et 7 1/2 1P8 would
he setisiectory. If so, we will purchase this instrument end then
try to provide the tapes with sufficient clarity for that purpose.

we

I have reed your letter of

March 2 with

ere going eheed with the design of our study. end

I

Iceberg end

first pert

of this tape through our
be
should
able to use the Isnherg
find thet e technicien

heve elreedy played the

foot pedal for transcription.
,

would be possible for us to send e technician to
it
to be treined by your eseistsnts. I believe that it might
ﬂow

I think

new York

be important to do this et s time when
and we can sets this erreegeeent later

York else,
I will he in
In
the meanthis spring.

tims, I believe the: I would like to make s tepe of one of our early
sessions, provide e transcription, and then send it on to you with
the request thet you critique our techniques. I! the recordings ere
setisfectory. we will continue to meke them.here end begin the enelysis
in the spring.
so concerned teletively little with the financing of these
studies. insofer es our loundetioo hes provided me with the authority
to use its funds to esteblish new studies. and these initial
expenditures ere within mq~hud3ets.
1

�2.

I would vury much like to spend noun tin: with Dahlborg, Stan,
yourself, since I bolicvu that your study provides a unique
opportunity for a aeasutumnnc of psychothornpoutic interaction. 1
lubjoot which no dtuouasud so often coma year: ago at Billstde.
und

Plans. call an about our tape. Thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:jm

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                    <text>April 1.'1965

-Joseph Juffe,

M.

0..

Committca on Research

Chaiumux

The kcadnmy of Psychoanalysis
125 East 65th suntan

'

New

York,

New

York 10021‘

Dear Joe:

I would be dalightad to attcnd your dinnar nauting at
v.5. on Friday, April 30. Lit. an outuofotawncr, I ha»!
altaady bought tickats for a numbat of plays in ordnr to catch
up on the high-11f: of new York. I haw: theatrd tickets for
that avening and so will b» pleased to work with you until

6300
‘

,

BI

15.

~

I

havu

'

just and. a second tdpe in our laboratory

and am

shipping it to you separately for tha'namn kind of analysis
that you made on the pravious cans. 'Hiny thinks.
Sincerely yours.
Fink. M. D.
Profaaaor of Psychiatry

Hex

ﬁFskp

'

P.S. Encloscd is tha second test tape and. en a Roberts
recorder with two microphone: in our laboucary. While ch:
two physician: sre stag. thy. shay did cadpcratt and I think
this it a fairly clean rucord.

,

‘

1: almost antistactbzy. I beliovn I can improva
on the situ;tion by stating up a 5903 Ind microphone and will

If thin

do

to in the aux:

week.

�</text>
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                    <text>Bomber 18,

Dr. Joseph Jeffe and
Dr. Stanley Foldstein

The mum» Almon Maine
20 West 7am Street
New Yetk, New York

1965

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material until next week. I should heve the analyses time by
Memes and will write to you at that time.
Mybest regards

fortheNewYm.
Sincerely yours .
Pink, NJ).
Professor of Peymietty

Hex

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                    <text>Dr. Joseph Jaffa
The William Manson White
20 West: 74th Stme't
New York, New Yoﬂc

‘

Institute

Dear-Joe,

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                    <text>April 25, 1966

Joseph Jaffe,

Chaim

PM).

on Research
Mixes
The
of Paydmmlyais

‘W

125 East 65th Stmet
York 21, New Yeﬁc

New

near-Joe:

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on practical aspects of monarch in office settings.
I fomd it 5 6011131th and easily madiblo waive,
dewdshtomxdyou, Claymsmymajob
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on therapy and the special problem of single
case study we amnllent.

upon

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mm

MylmggestﬂmtthisbonMavmahlemthe

mamhipasamportofm

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N
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'

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                    <text>December 29 , 1966

Dr. Joseph Jaffe

The William Alaneon White
20 West 715th Street
New York, New York

Institute

MJoe,
Myouformfomngm.ﬁdmms.ﬁowemus. I
mwitingtohimbocmserelieveﬂathismrmmlm

vimmflectstheqmlityoftmkimOfstaffmberthat
ImldbepleasedtomcmmexﬁtoAleedmn.
Incidentally,ifymaremtemaﬂ&gt;eroftln$ociety

for Psydxophysiologioel Research, perhaps you would like
tojoin. Myrnvemactivewxpaignonformxbership
and your present interests are clearly related.
Mybeat wishes fortMNewYear.
Sincerely

yam ,

Pink, M. D.
Professor of
Psychiatry

Max

Hszp

�</text>
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                    <text>March

Dr. Joseph

Jaffe

The William.Alanson white
20 West 74th Street
New York, New York

7, 1968

Institute

Dear Joe,
I have

the g;§.M.D,

a

read your report on deniie personality in
I found it very interesting and would appreciate

just

reprint when this is evaiiabie.
Incidentally I hear that Ed Heinstein

to Mt. Sinai this summer.
My

may

be returning

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>rwp—m-mmw

.

wm- -_._.,_..,

mem—

...mm.._.._,,, “M ,,,.

,__.i

‘ ,,_

ﬂ

.-,,.._,,,

.._,

,

.

,

W- V. __

,

my. a

W.

.

.,.

_.m., W.um mu».’5‘“...
.

,

7383:108FDA

Elmer Gardner, M.D.

Bureau of Drugs-

FDA

Rockville, Maryland

He: Inn 6590

Dear Al,

studies of levomothedyl are continuing, and we
recently submitted documents notifying the FDA that ve have
expanded the studies to my new facilities at the VAﬂoﬂotthport
and SUHY at Stony Brook.
The report: of the initiel studies have also been submitted
to your office; but in the event that these have lot been filed with
this IND, I am submitting copies herewith. The initial report
appeared in JAMA 220:811~813, 1972; end the second is in press in
The

the

same

Journel.

Thank you

for your reninder.
Sincerely yours,
./
r

”44

/

_/,u n.1,»

Fink, M.D.
Professor of Psychiatry

Max

mf/
Enc: Levomethadyl
JAMA, 1972
JAMA,

reports

in press

c

._, '—,~
.1

-W
.

.‘..m. _,

.7 w... _,,_ _.,_,_
_

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

�</text>
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                    <text>September 6, 1988
Joseph Jaffe, NH).
New York State Psychiatric Institute
722 West 168 Street
New York City 10032
Dear Joe,
vu, all over again! Yes, I do remember our little diagnostic
experiments, and I must say that our experience has inﬂuenced me all my life. In
our Hillside days, we learned that diagnosis was not particularly useful when we
were asked to treat patients, since from time to time, the obviously 'wrong'
treatment seems to have been useful. Our random assignment imipramine,
chlorpromazine and placebo studies laid the groundwork for the studies of
imipramine in phobic disorders, for example.
De}_a_'

In the 19703, when the APA committee under Bob Spitzer was devising the
Chinese
menu diagnostic scheme, I argued for consideration of biological
present
(at the time, mainly the sedation threshold and the nascent neuroendocrine tests)
and treatment results as cutting tools, arguing that the main advances in syphilis
came about only after the Wasserman test was devised. Such views were
disregarded as 'premature'.

From time to time I am asked to consult on complex cases, and usually I
discard the diagnoses presented in favor of any diagnosis for which a treatment
exists. A few weeks ago, I was sent a 25 year old man, ostensibly with
schizophrenia (2 consultants agreed), with the statement that BC!" was clearly
useless in schizophrenia and therefore neither psychiatrist would treat the boy.
This despite the record that 4 years earlier he had responded well, albeit for 13
months! We have since treated him and he is doing nicely.
.

Another case is that of a 56 year old confused and apathetic woman who
was diagnosed as Alzheimer disease, confirmed by a neurologist, and again by a
second opinion; consigned to a nursing home for 5 years. She was referred to
University Hospital because of a medical condition. When she was on our medical
service, our consulting team thought she was depressed. She was referred to our
team, and we could not agree on a psychiatric diagnosis; but since the diagnosis of
Alzheimer disease was untreatable, we suggested to the husband that since she
looked depressed there was the option of a course of ECT, which could make her a
little worse for a while, but if it worked . . . It did, and she has now been at her
own home for more than 3 years. (When she returned home, she could not believe
that her daughters were her own, for she had the Rip van Winkle syndrome,
believing that her daughters were five years younger.)

�Dr. Joseph Jaffe

Page 2

Another more recent case is that of a 25 year old married mother with a
history of lupus erythematosus, admitted in manic excitement, treated with
haloperidol, and seen the next day in a catatonic state. Internists believed she had
lupus cerebritis with epilepsy continua, and they tried various voodoo treatments
including high doses of antiepileptic medications; the psychiatrist laid on the
benzodiazeplnes (he feared antipsychotics as neurotoxic). The patient was
incidentally presented to my ECT training class and after some discussion, I argued
that ECT was the preferred treatment regardless of her diagnosis (lupus cerebritis
or NMS or epilepsia continua) since her main symptom was catatonia. Four weeks
later she was finally sent for ECT when her catatonia became the aggressive
variety and she required continuous restraints. Four weeks of ECT, and she is now
home, alert and well.

-

0! course, not all such agnostic diagnoses work as well as these did; but it
only takes one such diagnosis every so often to convince me that our present
disgnostic schemes in psychiatry, especially the Chinese menu approach of your
institute, is Rorschach testing in real life; and that more is in the eye of the
beholder than in the face of the object, despite the professional belief in their

objectivity.

_

'

'

Yes, i remember those experiments very well, and often tell my students
about them. Perhaps we should do the experiment over and publish the results in
the American Journal of Psychiatry? (Under pseudonyms, of course.)
Thanks for the very pleasant reminder. My best regards.
Sincerely yours,

Max‘ Fink, MJ).

�</text>
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                    <text>Flown. v'v—wur ...

~~. -

,

-

...\

-——

wwn-v-IyV-V‘wv‘ﬁ'mwrxt—I—r-m

i.

v.

—ww .,...-—- .,.,..,._w»m. vv‘m'" ,«u-wxui—«r-uu—rl‘w

,,_ on.

v

w "—wwpa- -W4.-——.-W-w.

mom—“Tn ~y-wmm~~.—&lt;

'vn

.
'w

wun~«m_n.v-.~

May

Joseph Jeffe, M.D.
Dept. of Psychiatry
College of Physicians and Surgeons

Columbia University
New York. N.Y. 10032

27. 1976

if

Dear Joe,

about

Thank you

my

for your recent letter

visit. I did

another opportunity to meet the

merit, that of

EST.

While

and

the nice

comments

enjoy the session and hope that I will have

at the

APA,

I

staff

on the other

had an opportunity

issue of

some

to chat with

Dave

is actively involved in studies of lithium maintenance
in a large clinic, He tells me that he has therapy responders and
non-responders, and the paper he geve on this subject was quite good.
I suggested that rather than having you relate to me at LIRI, with

Dunner.

He

all the distances involved, would he not prefer to work out language
measures as change scores and even as predictors of response to
lithium? He seemed delighted and I commend you to him. As I know
him, he is an earnest and herd worker, quite forthright and honest,

”vand

I

would be delighted

to

work with him.

If I can be of further help, let
collaboration works out.
My

me

I

know.

hope

the

‘

best regards.

Sincerely yours,

m:

Fink,

M.D.

Blp£. of Psychiatry

—»

-—-

mm.“

�</text>
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                    <text>.-IT!1'."‘-'-&lt;;'.n‘un-nvlr-‘~V

.L‘Imu'elAk-‘w-m

~v,r.~.-u«

.~

June 28, 1977
Joseph

Jaffe,

M.D.

State Psychiatric Institute
Street

New

York

New

York City

722 Vest 168

10032

Dear Joe,

I have just finished reading fStroke'. It is a moving and
thought-provoking document. Clay's trauma was an overwhelming burden,
which he bore with the help of his friends. As an emotional experience,
I cannot say that I am glad to have read the book, for it has made me
sad and reminded me of our mortality.
On

an

intellectual level, I

want

to congratulate you both
which are so personal and

for

clear,
the very fine exposition, the descriptions
and the picture of aphasia which I have never seen before. It set me to
recalling the many months I spent in the Bellevue library exploring the
works of Goldstein and Jackson, Critchley and Lashley to recall a few;
works that were indecipherable and impersonal to me then. Your volume seems
so much better, I can see it of help in the residency programs and in
the care of patients and their families who may have the same experience.
am pleased that one of my friends has
volume.
memorable
I congratulate you. Your loyalyy and
created such a
and
I
feel that Clay has indeed been fortunate
friendship shine through
had
have
in one respect, to
you as a co-worker and friend.
On

another level, I

In thinking about the book as a reviewer might, I can find
that I could criticize or question. I thank you for thinking of
little
and
sharing your work with me.
me,
My

best personal regards to

you and Nora, and

Sincerely yours,
Max

Pink,

M.D.

to Clay.

�</text>
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n.

April 30, 1968
Dr. Robert
‘

Jaffe

t of Neurology

Sinai School of Medicine

Mount

Fifth Avenue and 100th Street

New

York,

New

York 10029

Dear Bob,

for

Enclosed

is a

check

Dr. Bender on Hay 8.

for my subscription to the dinner
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M‘szp

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                    <text>April
Dr. Robert

30 , 1963

Jaffe

t of Nemlogy

Pbtmt Sinai School of Mid!»
Fifth Avenue and 100th Street
New York, New York 10029

Dearaob,

Enclosedisacmckfwmysubscriptiontotmdimm

forbr. Benderonﬁaya.

Sincerely yams ,
Fink, M.D.
Professor of Psychiatry

Max

MFtkp

�</text>
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Dre. R.

Jaffe,

Krieger,

H.

Sencer
Department of Neurology
8 W.

Mt.

New

Sinai Hospital
City

York

Dear Bob, Howie and Wally,

Nothing would please

me

more than to honor Morris on

his 75th birthday, and to meet with all my old comrades-in~ training.
I cannot attend, but in good spirit, and recognizing that you will
surely find something appropriate to record our debt to Morris, I
enclose the check requested.

Have a good

time.

Despite Morris' aversion to EEG, both then and now,
experience has served me well and my laboratory, which has been
dedicated to determining the effects of psychoactive drugs on the EEG
continues to be productive. Lately, we determined the normal profile
of phenytoin, aspirin, and are now working on some olfactory stimulants.
The experience at Sinai also led me to examine HOT and after 25 years,
I have put together a book which reports the clinical and theoretic
knowledge. I am most delighted with the latest theories, which hold
some promise for an improved understanding of the mode of action of this
treatment. The book, "Convuslisve Therapy~ Theory and Practice" was issued
by Raven Press in early 1979, and is already completed the first printing.
(It has also received an international award of the Anna Monika Foundation
for contribution to our understanding of endogenous depression.)
my

My

.v:

,

best regards.
Sincerely yours,

mgr

,.EV;W’hﬂ-'P

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>May

21, 196‘

Dr. I. Fianna Janna
Honorary rayohiattiat

Dopartlont of Paychiatry
Royal Perth Hospital

Perth,

Hostarn Aoatralia
Boar Dr. Janna:
During the past for nooks In barn oooaidarod your application
to tho Instituta with gtaat intnraat. It haa boon my renown
nandation and you havo been considaxaﬁ for a aonior clinical
position at tho Instituto. Bouavnr. that. is one qualification
for our clinical position uhioh you lack. and while I barn made
ovary after: to obtain agroanont to diarogard thia, I barn boon
unablo to obtain such agtnannnt. That in tho satisfactory con—
plation of the E.C.F.H.G. axanination.

I would raconnond that you ait for this axamination. and no
would ba ploaoao to roviaw your application again as soon aa
this qualification baa been satisfactorily not.
thank you vary much for your intarnnt.

Sinoaroly yours,
Fink,
m
Diractor
HF/jb

K9 Do

�</text>
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                    <text>W
Dr.

I.

23 . 1963

Pierce Jams

Hmomry Psydxiatxist

Departmnt of Psychiatry
Royal Perth Hospital

Perth,

Western Australia
Dear Dr. James:

for your inquiry. The Missouri Institute
the research and training center of the Division of
Nantal Diseases of Mssmri. It was established in October, 1962, with
laboratory and clinical facilities for maeamh. At the present time,
of 150 beds. we am utilizing 70 for research purposes. laboratories
are established in phamcology, psychology, and eleotmenoephalogmphy,
m well as a carputer center for both statistical and EG analyses.
There is a specialized psychiatric monarch library as a component part
of the Institute. Animal facilities are now being built.
Thank you very much

of Psydziatzy

is

In additim, there

residency training program
gram in clinical psychol

is a fully qualified three-year wychiatnic

at the Institute,

is

training proin the moearch

and a special

being established.

the Institute is affiliated with
prom and in the tramg prom,
the Department of Psydxiatzy of
Washingtm University School of Micine.
Both

Atthepmsenttim,tlummanumberofmsaamhpmm
These include Lithium

m a therapy for mania; the use of
Yohinbim as a precipitant of anxiety and the development of antimxiety mum; mlatim of EEG pattems and organic factom in the
tmatmnt of therapy resistant psychotim;
analysis of the
eleottmnoephalogmm; the effects of drug withdrawal on behaviw in the
dmmuioally ill; and tho treatment of psychotic: by name mlatimship
program.

War

therapy.

in

�Dr.

I. Pierce

James

Deoexnber 23, 1963

Page

'Dwo

Aoomnodations am available for rental or for sale within
ten minutes of the Institute.

Appointmnts are made at galaxy levels ammumte with
experienm, and for candidates holding the W from a board recognized
by the Division of write]. Diseases, the starting salary is $16,006.
Mjusmnte may be made for march experience. Allmanoee may also
be made for transportation to the United States under certain oonditims.

I am emloeing a $ecriptim of the Institute. If this Opporh
interests
tmity
you, I would appreciate a copy of your 'DPM certificate;
of
copies
your publicatims, especially the more recent ones which may
be in press; and a small photograph. Sit-mold be helpful if we could
have the names of at least two referees to whom we may write.
Pamnthetically, the Institute is affiliated with the Departmnt
of Psydﬁatxy of Washington University of which Dr. Eli Robim is the Chairman. His interest in the problem of suicide is met.
Sincerely ywxs ,
Max

Fink ,'

Director

M.

D.

Mfzmlg

Ens. 2

not familiar with appointments and titles in Australia,
could you clarify your present work situation as to whether you have
appointments other than at the Royal Perth Hospital?

PS:

As

I

am

M.

F.

�</text>
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                    <text>Mirth 10, 1965

William C. Janssen, M.D.
Director of Clinical Research
Lakeside Laboratories

1707 E. north Avenue
Milwaukee 2, Wisconsin

.

Dear Dr. Janasen:
For a number of years my sssooista Dr. Itil and I have been interested
in Ditrsn. Sinoe coming to Missouri. we hsvs ostried out s number of

investigations. prinerily of the effects of Ditrsa

encephalogram and on behavior.

As

on the electroyou know, Dr. Gershon hes osrried

out detailed bshsviorsl studies as well.

Sosetine last year you were kind enough to make available
supplies of bitten for animal use. At the present time we would
like to renew our studies as patients. and would like to request
sdditional supplies. Recognising the problems of working with en
experimentsl drug such as Ditrsn, we have presented our problem to
the Pharmacological Committee of this Beyertment. The Committee has
agreed to support our study program end has concerned in our filing
an IND with the FDA. if that is necessary.

I will be grateful if you would aﬁvise me as to tho beat steps
necessary to make supplies of Dltron available for human use. If an.
IRD is required sad we make such so sppliostion, would your pharmacological dopertnent be willing to make available the information
necessary for this form, defining the node of production of the drug
end

its

pharmacological characteristics?

Any

help that you can give us in this endeavor would be appreciated.
Sincerely yours,
Ms: Fink, M.D.

H!:jn

cc:

G.A.

Professor of Psychiatry

ulatt

r. Itil

�</text>
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                    <text>September 3, 1970
Dr. Paul Janssen
Janssen Pharmaceutics

Research Laboratory

N.V.

Boorsc , Belgium

Dear Paul,

First of all, let

of the

CINP.

have selected.
My

I can

me congratulate you on your election as Treasurer
think of no one more qualified that the College could

interest in the classification of novel

compounds by EEG

criteria

to review the printed data on sulpiride. It has been
studied extensively by P. Borenstein who has found interesting EEG changes
and for this reason the compound was brOught to my attention by an American
pharmacologist in the v.5. You may recall that I discussed this compound
with you in Prague and I am writing to request any proprints or published
data regarding the pharmacology that you may have available from your
laboratory.
has recently led

me

I would be most grateful if you might also list the
of your acquaintance who may have worked with sulpiridc.
My

personal regards to your wife.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

names

of investigators

�</text>
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                    <text>W»

Dacsubar 14, 1971

Paul Jansaan, M.D.
Janssan Pharaacautical Raaaarch
3-2340

Bursa . Bulgiua
Dear Paul:

It

Haxico City.

was a
Ha

plassura to boar your rsport and most you in
ars particularly intarsstad in narcotic antag-

ouiata. and art soaking a compound or formulation of long duration
with minimal agonistic fasturas. Dr. Canaron of tha W.H.O. suggaatad that you may have davalopod antagonists of high potancy
without agonistic fasturas.

If such coupouudo do sxist. I would be grateful for any
infatuation ragardiug their characteristica and availability for

study.

Should you praiar, you may wiah to bring such data to
the sttantion of our spacial drug abuse agaucy ~ Dr. Robart Rosa,
Spatial Action Oftica for Drug Abuas Pravantion, Whita Hausa,

Washington, D.C.
Any

ssaistanca you can giva our search (or a nora useful
ha appraciatsd. My boat rsgards to your charming

antagoniat will

Hits.

Sincsrsly youra,
Fink, H.D.
Professor of Psychiatry

Max

“:13
cc: Dr. Hobart
SADDAP

3...

�</text>
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                    <text>February 5, 1972
Paul Janssen, M.D.
Janssen Pharmaceutics
Beerse, Belgium
Dear Paul,

I have

first

You gave me so much

sorted

my

thoughts

to think about during

this week-end.

my

visit, that

I am most delighted that such longer acting narcotic antagonas R 15497 provide a basis for further development. Should the
minimal toxicology data, and supplies be available, we will file a
research IND with the FDA, and undertake the clinical testing to assay
the dUration and extent of narcotic antagonism (measured as the response
to intravenous heroin, 25 mg/2 cc saline/2 minutes) in post-withdrawn
opiate dependent subjects. We would also evaluate any agonistic features.

ists

Should

it

prove to be an active antagonist with a duration

greater than the available

the long-term clinical

compounds, we

trials.

will support

and undertake

I called Dr. Allan Green (U.S. Special Action Odfice, The
White House) and Dr. Jean Paul Smith (National Institute of Mental health)
Center for Studies of Drug Abuse) to tell them that I had reviewed some
of your compounds of interest; that these had been tested by the
University of Michigan and the data were in the appropriate archives;
showing these compounds to be similar to others already under investigation;
and that prior to further study, they required, as with M—SOSO, additional
formulations of supplies and animal toxicology studies to satisfy the FDA.
Dr. Robert Rees also called and I repeated these observations.

variety and special characteristics of your many new
fascinating. 0n the return flight, I read the many clinical
reports carefully, and am impressed that penfluridol should be an
The

compounds were

important improvement over our experiences with fluphenazine enanthate
and decanoate. I would like to evaluate penfluridol in our V.A. unit.
I have given the data to my associate, Dr. Alexander Don, and we will
write to Dr. Stevens at MsNeil, to ask him to visit with us on his next
trip to New York.

�.
L“

man‘s

“ac-'9.

Paul Janssenll.OOOIOOOIOOIIOOOOIOI. 2 IClo...-OIOOIIOOIIIIOFebruary 5, 1972
The usefulness of tetramisole as an antihelminthic is
dramatic, and the possibilities in oncology most exciting. It is the
alleged antidepressant activity, however, that interests me. We are
assaying one compound, ORE 8063, from Ortho Research, in our EEG
screen, but our methods may be more appropriate to examine the
possible central activity of tetramisole. I will call Dr. Bill
Pollack as you suggested.

With regard to haloperidol in addiction, I have reviewed the
available to me, and the suggestion by Lal is interesting,
though poorly substantiated.. I have intererted an experienced member

summaries

of my staff, Richard Resnick, to examine the data and he will design
a study, which will run in parallel with the ongoing trials of narcotic

antagonists.

I enjoyed discussing and reading the descriptions of the
compounds
other
in your catalog. You are to be congratulated
many
and
the
Special characterittics of your products. A
on
variety
30-day narcotic antagonist would complement your list most dramatic-

ally!

visit
visit

Your hospitality was exemplary; your family charming; and the
most memorable. Please give Dora my best, and trust that your
'down under' will be exciting and interesting.
My

thanks for your many, many kindnesses.

Sincerely yours,

“Whittx’GVG—"m'

,_

rw

m"‘-v.

waw-vwmcm-mmwui-Wmam

7r—’

wai'

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>—..

wwwmﬂwwvvrw-

——."—..Wv..v—.r~

«v.-

January 3, 1972
Dr. Paul Janssen

Janssen ?hsraaceutica
Beerse, Belgium

Dear Paul,

thanks for your letter of December 28. I plan
between
in Europe
January 20 and February 12, en route to
and
Athens,
will plan to visit your laboratories. I will write
Many

to be

or call and

make

the date more definite.

Because of the

potential importance of the study of
antagonists to the public health missions of our nation, I have
suggested to Dr. Jerome Jaffe of our special action office for
the President of the United States, that he send a member of his staff

with

me.

it is

If this suggestion is not acceptable, please advise

me.

his office that is responsible for the coordination of the
research efforts in the nation, any studies that may be undertaken will
be expedited if they are aware of the data at the outset.

As

My

best wishes for a successful

1972.

Sincerely yours,
Max

Fink, H.D.

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                    <text>July 11,

1963

\

William C. Jmeen. M. D.
Lakeside Laboratories, Incorporated

gamma»

wiemnein

1

Dear 1r. Janseen:
Trunk you for your letter of July 8. regarding new
investigations of drugs. I have discussed your letter with
Ir. Samuel Gerahm, me is the Inetitute'e phewaoolegiet.

are indeed interested in new compounds and would
you send up such infometion ee you may have
labia on both 10-029 and 10-189.
We

:1:

at that

The

animl facilities of the Institute are being
weak. The wards have been in operation

established this

fermymmthe andmemnowbeginningourﬂnt olin‘ieal
trielwithenewmm. Weehmldbeequippedtoeam
wt fujlyluraxage phameelogiael and clinical tests by the
early

all.

Thank. you

for yew interest.
Sincerely

Max

Fink,

Director

Hijr

mm;
Me Do

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                    <text>June 17. 1964

Dr. William C. Janssen
Lakeside Laboratories
Milwaukee. Wisconsin
Dear Dr. Jenssen:
Your recent inquiry regarding the potential value of a combination of
doaipramine and chloral hydrate was discussed with my associates, Drs.
Gershon and Itil.

It was my impression that the excitement seen with imipraminc was seen
in a group of schizophrenic patients treated with this compound, and
that chlorpromaeine or similar phenothiaaine drugs would be a logical
and satisfactory blocking agent. With imipramine. when a patient haa
become excited. the effect of barbiturates has been less valuable than
a phenothiaaine. However. this exocrience was in patients with larger
doses of imipramine. averaging 225 mg. per day.

It

Itil‘s

opinion that psychoactive drugs which had a beneficial
seemed to have both stimulatory
and depressing qualities. This seems to be true not only for imipramine
and anitriptyline. but for those phenothiazines used successfully in the
treatment of depression..
was Dr.

ottect'in the treatment of depression

There appears to be no a priori reason why the combination of deoipramine
and a dedating agent like chloral hydrate would not be a satisfactory
combination. Indeed, it the proper dose relationships were established,
one would expect the drug combination to be beneficial in proportion to

the sensitivity of the subject to the inipramine portion of the

combina—

tion with the potential salutary affect of the chloral hydrate. However.
it was our impression that the dose relationships would be critical and
we wondered what dose pattern you were going to try.
Finally, we did consider other drugs which might be effective in conjunc~
tion with desipranine and wonder if ehlordiazepoxide might not be a
better sedating drug in combination with deaipramine.
Thank you very much
some

help.

for

you

inquiry. I trust these

comments

Sincerely yours,
Ha: Fink,

Hrljb

Director

M. D.

will

be of

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                    <text>March

Hillian 6. Juntacn,

so,

1965

M. D.

Director of Clinical lnccntch

Lakcaldc Laborntorlos

I.

1707

lurch

Awunuo

Milwauk-o. Hisconsta 33201

”Cl! Br. Jlnnuun:
Thank you for yaut lmzzar conenrntng Dltrln. .I hope
that the FnA*vtll permit eh: continued study of this compound.
to continua our cradlna, and would
it at! not:anintotncecd
additiontl nupply of nitran for luvuuttgntianal
apyrlclct:
up: an loan as you but. Ellad tn. IDA.

-wtth rlgard to your quantion as to the prepoood 11u1t1~
clan in distribution of nitrln, I mu la no poultlon to make
a Ipnalfie nusgcszlou. I! that. it «can qunazlon in your
mind. 1: would not. to an advisable to pravida the drug in-

itially to than. luvs-tisneota

who havn

leuady had capgrt-

taco with tho compound. at null an that larger gruup of
lawn-tigctors who at! pnrtlcipnzlag la the aznn~rsc Early
Clinical Drug Evaluation Ptogtln. This list of insuatlgatora
:33 ha obtnland tram Dr. Colo.
Thadk you vuty unah

to: you: help.
alncntnly yours.
Max

rink.

K. D.

Profcsaor of Psychiatry

Ellipcc:

Dr. Itll
Dr. Ulett

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                    <text>my 25,

William C.

Janeen,

1985

H. D.

Nmtw of Clinical Research
Lakeside laboratories

1707 E. North Avenue

mm, anaemia

53201

Dearth. Jensen:

Atﬂnhﬂmﬂngefﬂnﬂnrwologimlcmmeofthienepemn

mletterswererwiand.1tmemgeetedtmtanoutlimofmreeeamh
night he of special interest to you and would provide a more definite
p
mmforpzwidingmwlthﬂnmtermmrenINDepplicetimtoﬂmfm
for true.
'

Duringthepest'amyeenwemvefmeedmofmrintemtmﬂm
prubluofﬁnlmgtmpeyehotiepeﬂmteinmmmmepime. Hehave

mimenmrofﬁmepetimtsmmspnmmmmdafter

emﬁmofmﬂulivinginemwﬁrmt,hevemdartekenﬁmirmﬁut~
mat with Mining ”diam. intensive yummy, and milieu
therapies. enmingﬁuﬁretyearwemebletodim-pebwtmtofﬁu

mp.

www.mwtedﬂutthenmenmofpedentam

feiledtoehwanympmeetohighcbseeofmpeychtmpicdmgmmdvery
limited
response to

endpentotlnl.

test done of e variety of
'

drugs imluding

LSD,

Semyl.

Inﬂneepatimtewemmrtoakepmmofmatmnﬁmusing‘
Ditrm, either alone er
with malaria-mm. The patients developed

eon-anaemia].

mm

stetewhiahomndhemtained mlybyrepeetedaminietretims.

wants, the patients We decrease
mmmmwmmmmmrmmmmumd
bylaw.
Msmrypuemedfwmymmmmsﬁmmedto
madﬂxissttdypmgm

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crouch repented

Forthiemeem.mwrvtetoyw1nﬂnmhmqmtingedditiaulmpplies

ofDitren. 31mmdomthaveﬂxisdrugevellable,werevemdemtriale
with etropineeee substitutemteredieeppeinted withtlnreeults. We
believe that our chemﬂam are sufficient to wment a
uteneive trial
ofﬂitmes atherepy inmtmnt resistant psychotics.

m

mmmmmmmmammmmimmmmim
fmﬂnRWlOgyCmittuofmis
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appllxicetinutotm
or

me'

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durum

42-

my 25,

1985

Inywmtmtw.yauhﬂimtathatymmplmmingtotmnm
ﬁndatatoﬂulmmwtmﬂm.

hitmsmyfwmtomitmﬂlthataapmﬂanhwto
minmﬂmafmu-m?

mmmmmwmmmmwha
emmw
hmldhamtofulfwwmmtimatthhmmdtw

mmmmm

My yum.

m

m: Pink.
mug:
ac: I».

Itil

13‘.th

mm

H. D.

of

�</text>
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                    <text>w.

A.

”1..

w-wm

.

Omwer

3.3

, 1965

William C..Jmssan, PM).

Director of Clinical Renard:

mm,Worms
Lakeside

Wisconsin 53291

Dr. Jeanna:

Dear~

Itil and I am pleased to unclean the FD 1572 and
ammd damn-nu, inclwing a pratoool for our study
with Dim. m protocol also includes antennas to our
Dr.

mm.musua1
mofmwabmgmtmﬁnmim
side arrears such as anathema and emu-dike state aupemms.

mfulDamage: mg: batman 10 and 15 mg
for 100 inmtigatim.
per Motivating}, and assuming that the mules will be
We

would bu

for a supply of Ditm sufficient

m pcr mule, we wwld mast 200 mum.
With vegan! to EBA, ma naming that the
will still be 30 Jag/10 no, we would must a like
7 1/2

200

mtmim
mm: of

mules.

Mymverym

formooopemtim.
V

Sinmmly yours,
Hex

)1ij
.

v..—

.

Fink,

M._D.;

Professor of Psydxiatzy

�</text>
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                    <text>Hawker 11,

Dr.

1965

Killian C. Janaaen

Lakeside laboratories

ﬁlm, Wismin

53201

Dear Dr. Jamaen:

W718.

and
ﬂunk you very mm far yam latter of
the supplies of Ditran ma TEA which have arrived safely.
Thank you also for ycur
mgaiding omoeptual disorgmizatim. We will keep these in mind during our study.

mats

Because we ham been intamtad in this subject forI scan
time and Dr. 11211 and I had been asked to write a chapter for
a forﬁawxﬁng textbook of psychiatry, we elected to make sma
drugs in treat~
wants regarding the use of almiicholinergic
is enclosed for your
m1: programs. A copy of £1113
information.
‘

War

You may almadj new that Dr. Gemhm has left them
laboratories to take an mother position in New York.

wmld be phased to haw yen visit us the next time
to St. 10118. Dr. Itil joins me in marﬂdng you.
for your
We

you com

Wmim.

Sincerely yours ,
Hm:

Pink, 14.1).

Professor of Psydximy

‘

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                    <text>August 12, 1969
Dr. Hilliam C. Janssen

Lakeside Laboratories
Milwaukee, Wisconsin 53201
Dear Dr. Janssen:

pleased to send the two reprints which you have requested.
The chlorpromazine-imipramine-placebo study in depression has
since been replicated by NIMH and you may be interested in the
reports which have appeared, written by Dr. Raskin. You may
wish to obtain some of the preprints from him directly.
I am

antidepressant study which you suggest
sounds interesting, but we do not have available a population
of chronic} depressives. Indeed. it is difficult to find
investigators who have such populations at their disposal.
The comparative

Have you

thought of undertaking such

a

study overseas?

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC.

�</text>
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                    <text>rabrunry 5. 196‘
Murray

8. Jurvik.

M.B.

Aaseciate Professor

at

‘

Pharmacology
Albnrt Einltaln College of Mbdlclao
Dcparzacnt

thhiva Univntstty

Eaatchttter Road and Mbrria Park Avenue
Rev York 61, Rev York
Dan: Hurray:
Your quostions are the must significant onus in the field of EEG and
pharmacology, and I «bald be delighted if I could answer than.1n g
fashion which would hlVe scientific significance.

with chm demurrer thtt the follnving answers avg a diatillatc of my
axpcrtcnnu. and the knowlcdga that an nra activaly working on that:
problems, the following are the answers at beat I can givu.thaa3
Psychotrapic drugs :uch an tnlprtuiuc.;chlarpramazlna, or lepro~
binaca induce chanscn in the aaalp recorded EEG which at: chnrlatcrintic for the compuund. The pattern: are tignificantly different an
vtnunl analysis and with frequenuy analyula aquipaant. (Raf. 1.2).
Fur group data. than, each paychctrupic compound seems to'havn a
charactertttle updatruu of resgonse.
1v

tatpanacn, howcvor. do anyond on the rate Ann tautc uf adulatatraw
clan, and also on the pro~trontuont record pattern. we are new working
on thn problan of whaehcr in an individual aase, the drug rasponso can

Thu

be

ldcntlflcd with corttlnty.

alloclnca. Dr. 1:11. 3nd I believe that with «at prcsent quaat££1~
cation method, we eta diatlnguiah in an indivléual subject caeh
psychotr¢p1c agent and also scpnratc diffarunatn baoad an rate and
dou‘sn. Th. lactct 1: now «nan: ttuéy with pantethnl. chlorpronazine,
and ditrnn. Wu hava salactcd than: agontc bccauac thoy represent
diffcxun: clnsncs of $russ~

My

t blind identification be
to-otrav, yna, with cast.

“Can

mada?”

...

toény. with difficulty

...

�Dr. Hurray E.
2w5—66

Jtrvik

Pug: Tho

(Parcnthatltally, it has bean av convictian that psychatttpic Grass
may be identttlcd not only for that: class of aattvtty, but far
chair tnlntivu potancy by taut: EEG studios. anﬁ I in now in tho
nacond yant of such a study. tact. 3]).
2. It to clan: that the EEG ratponac to a drug is ﬁcptndout on
many ﬂutters, thiaf of which at.: arug. data. rate, manta. and pra~
tr-atuont record. Thqra arc tau. nubjaata thta the psychologieal
stat: of th; individual may alto canttihuta to Indiviéunl difﬁctaacc.
no that tcaponulvtty to a drug may bu different in achitophranic;
duprectiva. naurotit. and payehopsthtc tubjcet.
The work of shagasc, Goldman. 1:11 and «that: indtentnl Chit ch;
EEG-response to a drug may hnvc a claaaifieatoty wtlua. That.
Individual differencas any he bath a limitation. if on: it Intcrustud
in studying the Ittoct at tha drug, at tn ndvuntuzu I! out trim: to
clauulfy subject.

quootton as to whgthnr alpha rhythm Being ytosent or cbntut
being a factor in drug response is net conclusivn, stun: nu hava
Ioatnad to ﬁclctiho a drug pattarn in 'low alpha tacotda' ’high alpha
reearda’. or ‘slow wtva rtcorda', with ralntiva 0‘86.

Tha

.

In my studies at uonvalotva therapy, I haw: cane tn the aouclnsioa
that Indutud tonvnlotan: are a dcvita ta chats. tha thalinotgicw
anttehaliuntgic—chouical pattern: of the brain. I htvt no ratpcct
for th: porn psychological unplannttoa a! BC! aetionb an: do I b¢11¢?u
that the para olcettophyaiological nodal: have any atria. new predates
syutennttt, daflnittvc cheudtal chtngel in tha tonttnl notvou: syutsa.
and it It 1a teaponaa to than: biothanltil chunsau that tha tubjcct't
3.

behavior

10

altared.

Thetufote, drug. which seem to opatata by altering tho biothgnieal cnbw
strait of the brain and EC? are hatiaally tha cane ”chant-m.~ It 1:
highly probable that a drug at combinatten of drugs ‘11! be found thtt
hgvg thc Iona btoahcuieal patttrnn as 361. Indead, a conklnatian like
ditrnn and thlotpronaaine produec EEG changes 31:11am ta EC! and as
you knew, both drugs seem to have an affect in daptoaaIV¢ syndrunet.
Therapeutic efficacy is direttly relntad to the degraa and type of bio~
chemical chang. at the brain, and ta that datunt EC! and ﬁrms thttayy
are very similar.
4. “Ctn u: predict tha effects of a drug In advance?"

no unuld

...

tine:

we

can't,

it

don't.

... if we

could.

on this ptohlcm, tad I think tbs falloutng
trans
givan
tn Individual patina: in tn: EEG laboratory
at.
In whom wt It. nbln to administer IctiatIu 2 or 3 aonpaunds Inttuw
venously to observe the EEG pattarn «hangs, in tan any tha fallowtna:

Nunavut,

in are working

utntaunntl

�Dr. Hurray E. Jarvik
2-5~6£

rtgu Theta

t

about a «hang. on Atutt adminlatratien. it will that
changc on thtonlc administration. Dapcndins an thn typc of
changn. that: at: certain sonatal ptadlctiont which can b: undo

If thc

EEG

tinilat

EEG

far behavior.
If ch.

886

than: tn intransa in tynthronitntlnn. a shift of frtqutau

ties to a :lount rang: and can. karat activity. it is likely thtt
the tubjaat will danoantrnta hchtvlaral changes of incrcatad
nadatlan. trtuquilliattion. ward yarticipntion. tna taut doctoasn
in the expretsion of anxiaty, hostility. tag. Ind itrlttbillty.
If the EEG show: increased synchronization and inatetcnd amounts of
fast activity. it is likely that lotitlixution‘ grasp participatlon.
and general activity level will increase. and anxiety. irrltdhility

will decraasc.

a dtcroala ln synchronisation. it in probable
that irritability, illutory tauaationn, halluciuntinns, thnught
disorder and anxiety will increase and withdrawal will baton»

If tha‘tecord than:
prominent.

To

the extent that these behavioral changes are maintained by
will believe that the tubjatt'a

environmental factor, obtarvetu
disuse: has been altered.

It hat btan

am

a pleasure to answer your questions. and I am enclosing
awn views in this area. I

rcfctances which may reflect my
pleased that you are interested.

a few

and I
Itil,
EEG
of
in
role

have jalaea tosathor butansc no have
psychiatry and clinical pharaacology
felt that thc
been
has
grosnly undetcttinnted and largely unexplorud ~ I say
bacsuna
I haw: on.ng dank the sallay proof of I bibliography
this
"EEG
and ﬁuman Pharmacology", conlllting as it dot: of
entitlad
580 reference: for the patina l951~62.

My

astoclatc, Dr.

’

Despite this large number of studies. that. It. anly : {an that haw»
pald attantion to th: problens of individual diffttcntas in subjects.
rate and rant. and doing. of drug, 1nd the fine point: of EEG :nnlyais.
It is tragic that most of tht urticltt deal with inch simpla conccptn
a: “normal - nbnorual“, tnd dony the fact that that: may be ﬂiffarcnccs
in the prtotteatmant retard which affect the drug responsa.
Lest yen ﬁnal that tbs animal pharmacologltts and neurophysiologllts
have done better. 1:: me rcaind yea that doapite such techniques as
depth retarding, «voted potentials, and inglanted electrodon. oinpla
ﬂout rasponsc turret. IPQC1BG dlffercntau, and individual variability
in animals hsvu been laragly disrugardoé.

�Dr. Hurray E. Jarvth

2-5-6‘

Page Four

It

has been a pleasure to chat with you in chit way, and I would
look forward to hunting yau and disculutng this in parse», oithar
hut. or in New York.
Bast poruanal regards,

”I! Fink,
ntrcctor

Mrljb
Em: o

H153.

�</text>
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                    <text>Ftbruary 5.
Murray Bi

1964

Jlﬂik. ”In.

Anteetatc Erofcnoor
Bopartnnnt of Pharaacalozy
Albert Eta-tutu Coll-g. of Mndietnn

Yeshiva unlvurntty

Enstchnltcr Bold

New

and Kerri; Park Arcnue
Yark 61, New York

Dan: Murray:
Your quuatlons are the moat ligulflcant can: in tbs field of EEG and
pharmacology, and I would be delightad if I could anawur than in a
fashion which would havu cciuntiflc ligalflaanco.

that tha fallovlng tutu!!! are a distillntc of my
cxpcrlcnnt, tad the knovladso that an are activaly working on than.
problnua. the following at. ch. annwaru a: b¢at I can gtvn than:

With the ﬂannxto:

lv Puyehotraplc drugs such as iuipranlno. chlotpru-nstna. or nuptow
btuata tnéuea chnnscn In tbs scalp ruuardQE 326 which are charaetcm—
lltlc for the compound. The patturnn at: significantly altfctant on
visual analysis and with treqnnncy analyst: equip-tat. (Raf. 1.2).
Far group data. than. each psychotropic compound nouns ta have a
characteristic spectra: of teaponln.
tauponsal, hov¢V¢r. an éepand on the rate and route of ndnlalatru»
tlou, Ina also on the prl~troatllnt canard pattora. W: at. new working
on tbs problem of uhsthcr in an iadlvldual «:30, en; drug tanponsc can
b. ldantlflad with eortnlnty.
The

associatn, Dr. 1:11. and I bellevu that with our present qututlttcation Inthod. a: eta diatingutnh in an individual subjuet «nah
pnyehotropic agent and 31.0 taparatu diffetauetu bnacd on rate and
deungn. Thu latter is new undo: study with pentothtl. chlarprannxlnn,
tad dittnn. w. hiVu Itlidt.‘ that. taunt. bccaunc thay tupteuant
diffarant classcs of drugu.

ﬂy

blind ldcntlficatlon ho nodal” ...
t
tc-otrov, y... with on...

”Can

today, with difﬁlaulty

...

�Dr. Mntrsy E. Jsrvlk

2&amp;5—6‘
Psgs Two

(Psrsnthstlaslly, 1t hss has: my conviction that psychotrOpic drugs
ssy hs tdsntlflsd nut only for that: clsss of sctlvlty, but for
thstx :slstiss potency by stats EEG studlss. and I s: was in tbs
sscand yssr at sash s study. (Est. 3]).
2. It is clssr that tbs EEG rssponss to s drug is dspsndsnt on
ssny factors, chief of which are: drug, dose. tats, route. and prs~
trsstssnt tscsrd. Thsrs srs sons subjsats whats the psychological
stats of tbs instvidssl may also contributs to lndlvléusl dlftsrsncs.
so thst responslvlty to s drug ssy bs airfarsnt 1n schizophrsnlc,
dsprssslvs. neurotic, sad psychopathlc subjsct.
of Shsgsss, Goldman. Itll sud othsrs ladlcstss that ths
rsspanse to s drug may have s tlssslflestory vslas. Thus.
individual differencss may be both a limitstlon, if one is lutstsstsd
in studying the effect of tbs dtug, or an sdvsntsgs 1f ens triss to

The work
EEG

classify subject.

I

Tbs question as to whsthst alpha rhythm Being present or sbssat
being s factor in drug response is not conclusive, since we hsvs
lsstusd to describe s drug pattern in '10s slphs racords'. 'hlgh slphs
*rseords‘, or 'slow wave records', with relative ease.

3. In

my

studies of convulslva therapy, I

have come

to tbs conclusion

that indussd convulsians sre s device to chsngs the cholinstgtc»
sntlchollnergic~chen1cal patterns of the brain. I have no tsspsct
to: ths pure psychological explanation of EC? action. not do I bellsvs
thst the pure electrOphysiologicsl models have any merit. ECT predatss
systeustlc. definitive chemical changes in the central nervous systsu.
and it is in response to these biochemlcil changes that the subject's
behsviot is sltetsd.
Thstsioro, drugs whleh'seam to opsrsta by altering tbs blochsnlcsl subu
strsit of the brsln sad EC! sts hsslcslly the same machsuism. It is
highly probsbls that s dung or cemblnstlen of drugs will be found thst
hsvs tbs ssse blaths-ttsl psttsrns ss BOT. Iuéssd. s cosblustiaa llks
ditrsn suﬂ ablatproussins produce EEG changes similar to ECT and as
yns know, both drugs ssss to hsvs sn affect in depressive syndromes.

thstspsntic sfflcscy

1s dissetly rslstsd t0 the degree sud typs of blow
chsswssl ehsnss of the brain, and to that extent ECT and drug therapy
sss very slsllsr.

A.

predict the sffscts of s drug in sdvsncs?”
... since we can't, we don't.

"Csn us

us would

...

1! vs could.

ﬁosevsr. vs are working on this ptobleu. and I think the folluwtng
ststsssnts ass trust gtvsn an ladlvtdusl pstlsnt in tbs £56 lsbotstory
in when vs srs sbls to sdnlnlstsr ssrlstls 2 or 3 cospounds lutrsu
venously to obssrvs the EEG psttsra chsnxs. us csn ssy tbs following:

�Dr. Hurray E. Jarvlk
2~5w65

Pagu_Thru¢

It

tho

on chronic

that. It. ctrtsln sonaral predlttlonn uhlth

change.

EEG

cant. udulnlatratlan, it will thew n
ndnlulttratloa. Dtpcudln; on tha type of

Ihﬂﬂl u chtnga on

EEG

31:11.: ahnnac

far hthavlor.
If tha

tie:

336

to a

than: tn lucrnaua

tiara:

fungi and

1n

nyuchrnnlxatlon, a

not. burtt nativity,

it
of

nan be and:

shift of

£rcqu.n~

1: likaly that
lactonoad

will ﬁauoantrata bchlvlotal change:
Inﬂation; tranquilllaatlan, ward ptrtlelpstlon. tad Iona ﬂattens:
in tho expression of auxlaty. havtillty, tag. and irritability.
thn subject

If tho

E86 show.

lnarantud aynahronllttloa and introasud amounts of

fast activity, it is likely that toelnllzation¢ group pnrtlclpntlon,
activity level will increase. and anxltty. irritability
will acetates.
and general

accrual. 1n :yuchroulxatlau. it in probable
that lrrlttblllty. lllutary stnnatlonn, hallucinations. thought
dlnordor sud anxiety will increase and withdrtval will become

If the retard

shown a

prouinent.

To

the extent that

that. bahtvioral

environmental factor, observers
diacasc has baen altarad.

chlnga1 are maintained by

will helluva that the subject's

It hat bean a plantar; to answer your quantiona, and I an antlotlng
a few refatcnccn whlch any tcflect my own View: in this area. I
an 91333.4 that you are interacted.
associate, Dr. ltll. tad I htva jalnad tegethar becansa HI have
thc :01. of EEG in pnyuhlatry and allnlcnl pharmacology
has bean gtossly undarcntilntod and ltrgely uaaxplared - I say

My

felt that

this bananas I have on ﬂy desk the gnlley praof of a bibliography
antltled "EEG and Kazan Phamnacology”. conulatiag a: it does at
580 reference: tor the parted 1951—62.

Detpito this largu number of studleu. chart at. only a fuw that hava
paid attention to the probing: of individual diffutunens in tubjtctt,
rate and rant. and 605.33 at ting. and the fine points of EEG analysis.
It in tragic thit most of tho artltlcn dotl with such simplc conetptl
at ”normal - abnormal”, and dtny the fact that thnro may be dlflcruatcs
in the prcwtroatnnnt rueord which tffctt tha drug rcsponsu.
Lest you tool that the nnlnnl pharmacologlata and nuu:0physlalog£sts
have done better. let me ranlnd you that 45:91:. such toehnlqucs tn
dcpth recording, cvaked potontltls. tad inglautcd cluetrodca, alnpla
date rcnponne canvas. Iranian diffcrunttu, and indlvldanl variability

in cal-ml; but. been largtly dltrcatrdod.

�Dr. Hurray E. Jurvtk
2*5-6‘
Page Four

It

has baan u plan-urn to chat with you in
look foruntd to wanting yon and dintutning
here or £3 new York.

this way, and I would
this in pctuon, either

Beat parsonal rcgardc.

Pink,
Dtrcntor

Mn:

141/1!»

Rue.

14.13.

�</text>
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                    <text>November 9 ,

1993M

E. Jarvik, Associate Professor
May
Albert Einstein College of Medicine
Dr.

Yeshiva. University

Park Avenue
Ms
York
Na: York, 51,

Bastchester 6

WW:

New

First, let

take this opportmity to thank
in discussing
you fw your mimmtim and
the many problem in supporting psycmatric research.

Was

me

In our discussim you indicated that you are
ocupleting a book chapter and I am taking the liberty
of enclosing a reprint of the mummy discussion held at
the C.I.N.P. matings inBinningham in September. This
review reﬂects my present thinking 'md is consistent
with the views of Dr. Ulstt and my Itil, my associates
in these studies.
please

If I can be of any further assistmoa' to
do mt hesitate to call on me.
Sincerely yours ,
Max

Fink,

Director-

ﬁlls

encloem

M.D.

you,

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                    <text>'I‘W-r—‘quuww

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1383-521
February 6th, 1973
Mummy E‘

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Unimnity of Californin. school at Main.
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none specific «poet: of bar interact, I will mung: for
bar to visit cithcr or both units.

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look forward to ageing bar.
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Proton-or 'ot Pnyehiatry
III/1.1

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                    <text>7333~Shh

derunry 16th,
Donald

1973

Jauindki, M.D..

Khrcatic Addiction Roscnrah yhniliﬁy,

ﬁatiannl Institute of Mbutal Ecslth,
Lexington. Khnzuchy.

Dust Don.
b

I have recently-been «shad to give a far loatura:
on the pharmncclogy of the_opiatus an&amp; the antagonists.
Iran a list of the contractors fur the Murijunna Comminnion,
I recall that you have written a report on the pharmacology
of opiates, particularly heroin.

I vauld

bu grateful

ir'rbu eould make a

I rscagnize that this is a prepr$nt,
appropriate credit.

to

ma.

many

cany nvnildbla

and

will give

thanks.
Rincerely yours,

an: yank.

M.D.

Professor of Psychiatry

writ:

mac.

In the spirit a! cxnhnnge, I
rayort to tho Gawain-ion.

P.8.
my

am

enclosing a «spy

at

�</text>
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                    <text>May

[

8, 1980

Dr. Mary Jasti, M.D.
thOhO Queens Boulevard
Forest Hills, New York
Dear Dr.

Jesti,

I regret to tell you that we lack facilities to support the
studies of lithium that you propose on behalf of yuur sister. Such
studies could be undzrtaken by the many laboratories dedicated to
lithium research.
Thank you

for your interest.

,
E

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>mmmrﬂvmmw

.

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October 20, 1969
Honorable Jacob Javitz
United States Senate
Washington 25, D.C.
Dear Senator
I

am

Javitz:

indeed grateful for your kind response to

my

regarding our role in the Viet Nam War. I wish
to commend your statements as published during the last
few days.
comments

I am writing to bring to your attention one of the
consequences of the present administration. Enclosed are
xerox capies of letters which I have received in my role

as a research scientist. These letters have been received
from the National Institute of Mental Health, both from the
Director, Dr. Yolles, and one of his assistants.

Our budgets for the coming year have been cut and we
be able to adjust. To do so it will be necessary to
curtail the hiring of new personnel and as usual, the impact
will most he felt by the trainees in our program.

will

Perhaps the most significant problems that we face
some of the new ideas that we have developed no
longer meet a receptive ear in Washington. I should like
to bring to your attention that on Wednesday - Viet Nam
Moratorium Day - I visited with officers of the Rational
Institute of Mental health to discuss with them some significant
advances in the treatment of opiate addiction and to request
their consideration of a contract in a sum under $100,000 -

is that

to provide

a means of extending the efficacy of a most useful
treatment of opiate dependence. I was told that no contract
funds were available and that we should utilize the conventional
grant mechanism - although the likelihood was just as bleak.

Our programs are reasonably well funded and we will survive
the present restrictions. The impact on new programs, on new trainees
will not be felt for many years. If this is one of the consequences
of the Viet Nam War, any help that you can give to returning an
emphasis on the part of this country to support of life rather
than the support of death will be deeply appreciated.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

~vwm‘Wu ,_,_
~

,

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                    <text>November 5, 1970

Honorable Jacob Javits

U.S. Senate

Washington, D.C.
Dear Senator

Javits,

The 1970 Comprehensive Drug Abuse Prevention and Control
Act contains the provision for the establishment of a commission on
Marijuana and Drug Abuse. The efforts of such a Commission may have
a significant effect on future drug abuse laws and community attitudes.
While
is always foolish to volunteer, I am taking the liberty of
enclosing the curriculum vitae of Dr. Alfred M. Freedman, chairman
of this Department of Psychiatry and the mainspring of our studies
of opiates, opiate antagonists and marijuana; as well as my own,
If there is an orderly process in which such recommendations are made,
and if you and your staff deem it useful, I would be pleased to have
you recommend either for service on or with this Commission.

it

Many

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
School Of Medicine
Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry
73SB—668

The Honorable Jacob

Javits,

Senate Office Building,
Washington, D.C. 20510.
Dear Senator

Javits,

During the past few years the President has sought
support for discontinuing research training funds. The
impact of this effort on research and teaching is far
reaching, and Representative Paul Rogers has introduced
legislation to reverse this Presidential decision.

I should now like to solicit your support for
56h0, "The National Research and Traineeship Act of
1973", when its equivalent is introduced in the Senate.
This bill would restore research and teaching fellowships
tith a) a ceiling on the total amounts to be spent, b)
a proviso for a return of two years of service for every
year of support and c) a limit of three years of support.
Such provisions should overcome most of the objections to
the previous programs.
HR

This bill would allow continued progress in the
development, through research, of safer and more effective
drugs for treating various illnesses and for the best
applications of drugs for the treatment of patients by
practicing physicians. These are matters of concern to those
of us who consider ourselves as clinical pharmacologists,

but in the broader view,.this bill will assure a continuing
flow of researchers and teachers for all fields of medicine.
Thank you

for your courtesy.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/ij

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                    <text>Deceﬁber 13th, 1972
Donald Jenden, M.D.,

Department of Pharmacology,
University of California,
Los Angeles, California.
Dear Don,

I very much enjoyed our discussion in San Juan.
Should the Opportunity arise, I lock forward to greeting
you in New York, and will try to visit your laboratories
as soon as I am able.
'

I

am

enclosing a few reprints which describe our

point of View with regard to ECT, and a preprint of a
summary of our work in EEG profile analysis.
The naw methods whiah you described for the measurement
much more exaat than anything we

of acetylcholine seem so

have had before,

that their agplieation to the

should be most rewarding.
my

EC?

problem

best regarﬂs.
sincerely yours,
Fink. “GD.
m
Prafassor of Psyehiutry

mu
Ema.

�</text>
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                    <text>Howunbor 22, 1971

Dr. Donald

J. Jcnder

Department of Pharmacology
UCLA School of ﬁcdiciue
Los Angeles, California 90024
Dear Dr. Jender:

l was pleased to hour of your work and the techniques for
measuring low levels of acetylcholine, at the ﬁIHH meeting Friday.
Some years ago. in studying the electroshbck
process, the specificity
of anticnolinorgic drugs in reversing the ECT effect led me to poatulcte an elevation of acetylcholine as important to this effect. We
attempted some measures of CSF acetylcnoline, but our results were
unreliable. Recently, I approached the problem again, and sent some
fluids to Walter Essmau at Queen's College, ﬁew York, but he was cola
to measure other constituents, not acctylcholine.
Are the techniques yen describe ouitablc for CSF? is there
a way of stabilizing CSF~acetylcnolinc so that samples could be shipped?
Would your laboratory be interested in some samples of CSF in monkey.
and man, before and following ocizurca, to test the hypothesia
ccetylcholinc eiotation occurs and persists post~ECT7

any

I an enclosing a copy of my 1966 rcport,
relevant citations from your lnborctory.

and onould appreciate

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

ﬂF:ig
Inc.

that

�</text>
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                    <text>Jmuary

Dr. F. L. Jenkner
Weniebwmmtmsso
8mm

Gm, Austria

1.9, 1956

20

‘MDhJenkner:
Dr. Bradley and

I are pleased to

confirm the

invitation for

'

your participation in the symposium on Antiduolinergic Hallucinogeno
at the forthcoming meeting of the GIMP to be held in Washingtm, 0.0.

on mm 29 and 31. We look forward to the presentation entitled
”Ddsturbmoes of Consciousness and the Application of Antioholinergic
Oanpmmdsf' As there are still a few questions about the ability of
some of the European invitees to attend the meeting, it will be a
few weeks before we can send a definitive program and time schedule.
.

at this late date the oomittees of theCINP are unsure
the
as to
availahility of support for the invited participants.
Even

Dr. Bradley an:

I have

rammed

some

finmoial assistsnoo for

ymrthieipationinﬂzissywoeiun. Wehavebemtoldthatthe
distribution of fmds may lie with Dr. P. Deniker (Hopital Ste. Mn,
1 we Cabanis, Paris 1149. Prunes). Dr. Bradley and I have written
to him and we would suggest that you wits directly upon moeipt
'

of this letter.

is en intemational fellowship society dedicated to
meeamh in pay-chophameoolngy. The letters stand for Collegian
Internationale NeWPsyohophamaoologimm. 'me society was
organised at the time when the World Congress of Psychiatry met
in Zurich in 1957.
The GIMP

will be presented during each three hour session,
allowing thirty—five minutes for each presentation and discussion.
Since tm discussion my be of special interest to the participants,
Five reports

the report should be about

this

23 minutes

it. longth.

The CINP has permitted us to consider the publication of
symposimn separately.
Insofar as this subject is becoming

increasingly iwoxtmt. we believe that the association of the
of the participants in a single values will be a valuable
mtnlbutim, weekyourmmtiminmakingamanuseript
available at the tin of the mting.‘1he mwoript should
be approximately 20 pages of text. plus bibliography and

work

illustrations.

�Dr. Jemima

~2~

January 19, 1966

In the event that

we would be planned

yomr fawn]. participation is not feasible,
to omsidar the inclusion of a mummy of
volume

your work in the pzwosed
We

look forward

if at all

possible.

to your participation.
Sincerely yours,
Fink, PM).
Professor of Psydwiatry

Max

�</text>
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                    <text>W12,

1965

Dr. P. L. Jenhaer
Department of Neurosurgery

mimisol'ten Klinik

University of Grez
Grez, Austria

Dear Dr. Jemmer:

in

for the forthcoming
Prom Mitten
1966 has asked Dr.

The C.I.N.P.
Washington on Here:

and myself

to

plugseoolggy.
sub eat 0 :

We swim
We

meeting

Philip Bmdley
on the general topic of new
a
have decided toarmnge a sympoeim on the
”~31,

W

WCHOIJNERQIC

.

Mtidxolinergio huluoinogmo have received considerable study
and ﬁre data relates to the problem of central nervous system
in the therepeutio effects of mime
dmlinez‘gio
emetic treetmnte, md to the special problem of the dissociation of EEG and behavior.

mime

Mixing your experienoe with these oanpomdo and yum

interest in theme problem we would like to invite you to
participate in this amoeba.
1. If you are able to aooept this invitation, would you
please send me e pmpoeed title for yew presentation , and a

short pamgmph describing the foam and type of date you wish

to present?

,

Upon moeipt of these admowledmnte, Dr. Bradley md I
willmeke upareoomendedpmgmbalenoingthetim for
presentations and disoussime. ‘lhe 62.1 .N.P. Cormittee has
agreed that this synposim will have at least one session of
simltmeous translation, so that reports may be presented in
the language of your moioe.

'ihe C. I. N. P. has not stated a general publication policy
and we propose to publish these reports and dismeeions as a
eepamte volume.
2.

that each participant will pay
in attending this meeting. For those attending
from Bmope, e charter flight may be organized by m». Philip Bradley.

his

3. The C.I.N.P. antioipetea

one: expeneee

�Dr. Jonkner

~2-

Novena)? 12, 1965

In the event that travel funds are necessary, please indioate the
m1: muested to supplement your available funds and we will
transmit these requests to the Prom md Waive Comittees
for their decision.
a. The Committee has asked that
being made by:

we

indicate arrangements are

Miss Margaret K. Taylor

o/o C.I.N.P. Secretariat

Wuhingtcm,

If you an pinning to

dimctly?

‘

Dr. Bradley and
sympoaim.

ac.

201310

attend this vmting,

would you

write to her

I look forward to having you join us in this
Sincerely yours ,
Max

Fink,

H.139.

Professor of l’eymiatry

�</text>
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‘-&lt;-r‘wl.’v

October 5, 1970
Hhitmore Jensen, Vice President
Ayers: Laborstories
685 Third Avenue
York, New York 10017

New

‘

Deer Mr. Jensen:

It is

with regret that we must pert - I have enjoyed Ayerst's
and the novel manner of sending them. The first day cover:
were attractive, (I have them all, although I am not a philstelist)
end brought your message promptly to my strention.

letters

Ave

atque vale!
Sincerely yours,
Pink, M.D.
Professor of Psychietry

‘Mex

HP:kt

�</text>
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                  <elementText elementTextId="106634">
                    <text>run-v

-»

“w ""‘W.xw

"nus—rm“

v

.

y,

_

z

_,,

,

,7.

..-

_

,

....,.

4.-

-

,

.

a...

.4

”W

V

vw,

erymu—mqu Hum-mm .iu‘. our“.

I73 007I
73I—OOTI

January
Jersey Tab

5 e 3-973

Co.

6&amp;9 Runway Ave

Union, new Jersey 07083
Gentlemen:

to

my

Enclosed please find payment for e shipment of cards sent
attention at BURY at Stony Brook. Note, for your records.

that the purchasing organization is cited on this stationery, and
the organization is tax exempy. The appropriate certificates are
submitted for your

files.

'

Please honor future orders submitted by my stuff in my name,
shipping to the address at Stony Brook, end bill to this organization.
.

’

Thank you.

Sincerely yours,
Max

Fink.

M.D.

Executive Director

-~-.

wv—uw

�</text>
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                    <text>r
«v-

'm’m'l""

rwr—U‘

June 29, 1970
Miss Irene Jeryn

Hospital for Sick Children
Toronto Canada

Dear ﬂies Jeryn,
Your recent request to the Psychiatric Research
Foundation of Missouri to purchase a copy of PRF 66~1 was referred to

me

for reply.

Unfortunately, the supply of this report is exhausted, and

your order cannot be

filled.

In the evnt the

specific questions,

we

to the address above.

scientist requesting this report has

would be pleased

to anauer these, addressed

Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>731—022CT

January

ll,

1973

mm'wr

n‘ﬂwrwwr'wmwmw

'WW

4..

v

w;—

‘."'1wIIv&lt;/"Y'V;w"wr-w‘"r

7-“—

WWW."

"*rr'rw

*7m;W.-'

~wrmvr‘x'lr

Dear Jim,

It is

to be back at work again. I very much appreciate
your optimistic letter, and hope that we can do as well.
good

Enclosed is the Dornbush and Williams report. They have
been writing to each other and shared a number of drafts. This one
is still in need of some assistance, and any suggestions you care
to make will be appreciated.
many

thanks.
Sincerely yours,
Max

Pink,

M.D.

�</text>
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                    <text>,WWW-W-r"

-

'1'

..— \-

m« .m-

WV.

r-vv vvnu'v ".Mu saw

wmuwcmmmm-Wmmru=a-,—l..-.‘v~.-.“w-r.:-'zv&lt;:

w")

r

,

,3

r

V

-

,

WW

.

August 1a, 1967
Dr. Jae mandala
Department of Psydhiatry

,

,

University of Pennsylvania ~
Philadelphia, Pennsylvania 1910a
»

Unear Dr; Mandela:

I

just read your lateet report on ”The Prediction of
to Electrcconwulsive Therapy,” in the Amznican Joannaz
05 Psychiatny. I found the repcrt of considerable interest
be¢ause it damonstrated anca again the yredictive nature cf the
have

Response

psychopathological syndrome in tha treatment response.

are undertaking another study of electroconvulsive
treatment and I would be grateful far reprints of the three
WE

earlier articles on this subject thch
Baitééh Jounndﬁ

06

Paychiatay.

,3

appeared in the

.

Incidentally, I‘enjoyed our shqrt ﬁiscussion very much
during my recent visit to North Carolina and wculd like to
take this oppartunity to Wish yea the best of regearchclimates
in Philadelphia.

A

',‘TSinGErely ycurs,

.

.3

‘

.

Max Fink,

ervm

M. D.

,

Professor of Psychiatry

Mfzkp

r
“ward":

‘

v

.

�</text>
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              <elementText elementTextId="29323">
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                    <text>war-Fr.

April 9,

w...

~..

'R.'vm'r-rv

Dr. Milton H.

«”qu

.u—s

u

~

Chief,

Joffe

Drug Sciences

‘1‘

WWWvu-su—n-v mmwm-wmw. W"

w—w—rz—r-«w-n—v-v

1970

Division

United States Department of Justice

Bureau of Narcotics and Dangerous Drugs

Washington, D.C. 20537
w“.

e

Dear Dr.

Jeffe:

There are two programs relating to substance abuse in the
Division of Biological Psychiatry of this Department.

study program "Quantitative EEG Studies in Psychopharmacology”,
partly supported by MH-lSSSB is dedicated to determining the relation
of changes in brain fonction in psychiatric patients and volunteers
in response to established and experimental psychoactive drugs.
A summary of this work which has been continuous since 1954 was
published in 1969 and reprints reflecting this experience are
enclosed.
The

Our second program is dedicated to substance abuse, particularly
opiates and alcohol. This program is largely supported by a contract
with the New York State Narcotic Addiction Control Commission. The
focus has been on determining the clinical efficacy of various psychoactive drugs in altering the drug dependent state. We have published
our clinical results with methadone, cyclazocine, naloxone and tybanate.
Because of our interest in neurophysiology, we have applied the
techniques to our abuse studies and have reported the EEG changes
with methadone, cyclasocine, and naloxone.
Copies of these reports
and some of the preprints are enclosed.
same

.wwwg...‘

W'-‘l

-n—

;.-,m-rwmrv.

\
‘3

;
i
F

g
k
P

,

This program of research in substance abuse is new extended to
alleged substances of abuse, notably marijuana, hashish and THC. While
this work is unsupported, we are optimistic that the National Institute
of Mental Health may look upon this work with favor.

mwv u".-

�Dr.

Joffe

April 9,

~2~

1970

One of the special issues which has interested us has been
the pharmacology of heroin and methadone. We have utilized
intravenous heroin as a “challenge” to the cross tolerance of
methadone and the antagonism of cyclazocine and naloxone.

put this program in its proper perspective, you should
that the principal investigator of some aspects of this
nrogram is the Chairman of this Department, Alfred M. Freedman, H.D.
Me is also co~director of the Center for Studies of Substance Abuse,
another division of this Department, under the direction of
know

To

Professor Richard Brotman, Ph.D.
I

trust this information is helpful.
Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

Mﬁ:kp

�</text>
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                    <text>7483~057SB

l

Fabruary 1974

.

M

t

.

.

a,“

my.

”Flux"

1::‘--»v-..;v:‘.\pw:nmr.'.-.

r
u

Murray Weinar, M.D.

Vice Pranidnnt-~Rss¢arch
Laboratory Sciences and Clinical Pharmacology

Marrall*National Laboratories

Cincinnati,

Ohio 45215

Dcar Murray:

I will

either you or Peta: Siegler
ara still interested in stadium of antihistamines.
I am not planning to attcnd the NYU alumni wanting on February 23,
as I will be away on a ski trip. I can man: with you the wash
of the 25th. should you b: staying ovcr.

visit am.

my

bu delighted to have

We

best rcgarda.
Sincerely yours,
Pink, M.D.
Profassor of Psychiatry

Max

MF/eis

�</text>
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John Wiley and Sons, Inc.
805 ‘mird

New

York,

Am
New York 10016

Gentleman:

Main
inmhsshemmimortmttsmaiaelapplieatimafdigitsl
those
neﬁnds. Of the
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electrical signals

qumtitstive analysis of

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to

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them than.afevolosdpotemialsmdmy

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'nneleatrmiamﬁndsof
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mlysishavemeentlybememiudbyapopularmvisw
‘

mimabythevietmﬁmmdistrimmedinmlatim
hyﬁnnepmntafcatmm.

infmqeemy,
ﬁndsseaiptimofcbsngss
Weapon: isresulting
from anesthesia, augs, sleep, etc.
pattem and
ﬁnes labomtaries have develapsd vamws wpliaatims of
digitalm’dnds farthesep‘nposes. Wehavemesivedmym—

mum

qmststorumpmomsndhswbsenwgedmsmimﬁds
inhmtiminatedmieslmmml. Webelievsthatﬁmis
medfarsudzaudvﬁealdammmbsmedemgemrally
availablsmnmsermngitmwaarmmidemﬁmfar
publication. If this interests ym,wswmldbspleasedsa
discuss upwiaeﬁan and mdifieaticns that may be necessary
taprovideammgsmrallyappliaablsdoamnt.
Thank you

for yaw consideration.
Sineemly yam-a,
Mm:

Firm, EM).

Professor of Psychiatry

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                    <text>Jmmy 22,

W

m,- E.

19%

JOhD

Dapm‘tmnt of Psydﬂatry
Yeti: radical Collage
E 105th Street
Fifth
New
Haw York,
York

New

Am

Dear Roy:

Letm takeﬂxisopportunitytoemssnypemmalthanks
and those of the society for your pmidpatim in the sessions of
the MN? last week. The diamssicm m the sat-20m day follow-sad much
-.did

1:th

first

with miéembly more spirit. Keith
a
maxificant job on Saturday ramming smamriiaing our emeri'ema, and
I hope that these beccm the bases for a. more public pmntatim in
the near future.

like

of the

'

Good

luck in your

new

poeitim.
Simmmly yams;
Max

Fink,

13136th

Wmlg

M.

D.

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                    <text>Yeoman! II, 1966

Dr. E. Roy John
Dcpartxmnt‘ of Psychiatry
New York Medical Collage

Fifth Ammo at 106th 9mm:

New

York,

Now

York 10039

Dear Roy,

Ofallthemmbam ofmyataff, themsttalcntodie

nomad Shapiro, who is the Dinetcr of our oonputcr facility .
Don has just convicted the Emmi minus program in
sciences at 'Waahingtcn Driveway. I know that he is motive
and while he will compic’ce the
with me here, it is
highly likely that he will seek another opportunity this summer.

War

prom

Iwggestedﬁmmlmmmitthcoomge. named.
mdhewillominmﬂmday,hbmy 21. Ihopeﬁwtthis

datoiscmmnioutbeoauserwmldwmmymmhavayau
motmﬁpeﬁupohmyouoronecfmassociatasspendsom
timdasm'ibingycurpmgxmtohim. chinbeatﬁlemnega
abmtmwOmmdAl's memmkew‘som schedule for
A

copy of

his Wanton Vita: in minced for your infomtiql.
Sincerely yours.
Max

Pink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>.— w&gt;=vw-r-:Nn'r—"-vv e-w-T

May

20, 1971

Dr. Diana Johnson
Biomedical Information Scientist
University of California, Los Angeles
The Center for the Health Sciences
Los Angeles, California 90024
Dear Dr. Johnson:

Enclosed are the corrections you requested. Is there any
reason why you would not use the author~prepared abstract? I

would

prefer

it

to the enclosed version.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

NF:kt

“an..."

.

V

(“yawn—”w no

-.r mum—"p“

�«wk;

The

‘v

Vw—

.~

7;»

'r“

7.7.7.

~...v

..

A..—w. war—w 1-—-.

.

:--

—'—-—m;-mumg.:_

nu annrnqwu-w. ._W«yp,— vyy-

-

-.v~.7r.-,-r..—_«

tn“.

-

7,7,

,

.

.

wy

ru— 1n»-

therapeutic effectiveness of unilateral electrode placement

and multiple
R.

;- -..

seizures in convulsive therapy has been studied

Dornbush, S.

Feldstein,

R. Abrams and

J.

by

M.

Fink,

Volavka (New York), with

the goal of reducing confusion and other side effects of such therapy
while maintaining

its beneficial action.

Seizures with unilateral

electrode placements results in less clouding of consciousness, earlier
waking, and less memory impairment than bitemporal placement.

bilateral

ECT

produces

its

Conventional

major impact on auditory verbal memory,

short~term memory is influenced

little

by

either unilateral

bilateral

and

Visual

bilateral

result in prolonged EEG
slowing with larger amplitudes over the left hemisphere, while unilateral
ECT produces higher amplitudes on the treated (right) side.
Bilateral
ECT is usually clinically more effective and faster.
There is a persistent
advantage to bilateral ECT for the first 4 treatments, but little difference
thereafter; an equivalent clinical effect was seen for 5 unilateral versus 4

ECT.

The EEG

seizures produced

bilateral treatments.

by

The use of

multiple

ECT

ECTS, 4

or

6

hyperoxygenation, appears to have approximately the same
as the same number of single treatments.
ECT

It

per day, under

effect

was concluded

that unilateral

is almost as efective as bilateral treatment, withoﬁttthe

memory

loss.

on memory

accompanying

Further study of multiple treatments are necessary.

has been thought that treatment effectiveness

but the persistence of slow

wave

is related to

activity appears to

memory

It
loss,

be more important.

V

7-;

�</text>
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                    <text>Kovcmbor 213%, 1972

HI. Diane Johnson, 8.3.
337 Whterside Ave.,

Horthport; H.Y.

Dear Mh‘ Johnson,

I have finally checked with the V.A. and I vunld
uypreeiate your completing the enclosed form of
:pplication. Please return it ta me at Stony Brook, and
as soon an

I have

it

I will process this.

Thank you.

sincerely ycurs,

M3: Fink, M.D.
'Profeasor of Psychiatry

MF/ia
Rue.

�</text>
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”my

”—1.4.

.-.&lt;

{.‘A

-.

rug-’1'"

June 9, i970
Dr. Fred H. Johnson
l58 N. Humphrey Ave.
Oak Park, Illinois 60302
Dear Dr. Johnson:

regref
curriculum vlfee.
neuroanafomy.
in
or
neurology
do nof have a posiflon open

IT was kind of you +0 send your

The? we

When

was

in

I

discussed

for psychiefrisfs

I

opportunify wlfh Dr. Nurnberger, if
in Training who were parficularly inferesfed

The

clinical psychiafry or oplafe dependence.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychia+ry
Mszf

�</text>
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w»

..
w

v
..-

'umw'“:v1r-

”Vt-0

vux'l-r-mz

-vn.-v-\.r-.

,1

”mu

A

w:

June 9, I970
Dr. Fred H. Johnson
I58 N. Humphrey Ave.
Oak Park, IIIInoIs 60302
Dear Dr. Johnson:

II was kInd of you To send your currIculum vITae. I regref
Thaf we do no? have a posIIIon open In neurology or neuroanafomy.
When

was

In

I

discussed

The opporfunIfy wITh Dr. Nurnberger, IT

for psychlafrIsIs In Tralnlng who were parfIcuIarIy Inferesfed
cIInIcaI psychlafry or opIaTe dependence.

SIncerer yours,
Max

FInk,

M.D.

Professor of Psychlafry
Mszf

�</text>
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                    <text>October 11, 1970
Mr. Nicholas Johnson

Commission
Uashington, D.C.
FCC

Dear Mr. Johnson:

Congratulations on your einellent report in today's New York Times.
to divide the country, and to intiﬁidate the
networks than any man in this century.

Mr. Agnew has done more

It is particularly refreshing to see alcohol

and tobacco put in
dominant
of
the
drug killers of our
their prOper perspective, that
As
and
worker
research
in
a
a principal exponent
generation.
Opiates,
of the narcotic antagonism approach to opiate dependence, Ilave been
repeatedly angered by audiences and politicians who insist that heroin
and Opiates are the principal killers. Mr. Agnew's identification of
youth and the anti-establishment with Opiates and with cannabis is a
P.R. ploy, and your article is the clearest statement against such a

divisive program.
Again,

my

congratulations,

heard from the Commission.

and I hope

that your voice is indeed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>"w w“' 3“,... ya- “a. yttrium-Arc.

“nun“... “amp; )m.uw;r

wumnmﬂrmwauw

wv

:r-zm-r

.

April 8.

1965

Jaw”
SWWle
5,
st.

MP.

Gill. F.
1.001.

Dear Mr.

W

Johann:

nut mating

Dim

of the
of tho Board of
Research
has provisionally been
not for May. June it, 1965. at 12:30 pan. at the Hisawri
Athletic Club. If than is
problam with this date,
would you plum can my ofﬁce?
Tho

mimic

Wm

m

Sincerely ,
Max

MPajm

Fink. Nd).

waive Dimator

�</text>
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                    <text>,

Br.

ow. r.

W»

22,- 1965

.1de

Bruxtmor Plaon
St. Louis ’5, Missouri
3

Dar Mr. Johnston:
moloood are copies of tho Board's resolution
regarding the budget of the Missouri Institute of
Psychiatry ,uhiohwa‘asmttoﬂueomaor,mdtha
Govem's reply whim is sent to you for your

infatuation.

‘

\

’msnextmtingof‘that‘omdatimwinbaa

on may, January It, 1966.111:
1mm meeting
the
paint Missouri Athlotio Club (has Washington,
St. unis, Missouri). The agmda will be short and it
in plmd the mating will and before 2: 00 pan.

12:20

Sincerely yours ,
Max

Pink,

PM).

Emmi“: Director

�</text>
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                    <text>7383535~A

Fibrunry 15th. 1973
Joan

!.

Johnston,

Drug Abuma Information Programn.

Biologictl acionecs Conunniaation Proacct,

The George thhingtan university Mbdical Center,
2001 S attest, N.W..
Wishington. D.C. 20009.

ur. Johnston.

Dear

I think a monthly newsletter reviewing programs in
narcotic antnsonists unuld be a utufnl effort, and I am
pleasud to anniot you in any way that I can. If it is
not useful, it at leant can be fun, and I suggest that

you

try.

I an willing to contribute enmnantu. if
spacitic quantions.

you phrase

one of the things whiah I think eould be useful in
an early taunt in a 113% a: the ecntcrs in the United

status using narcctie an§nganints. their present axporicnae,
drugs used, etc. A ao¢ond attort might be to ask each
at the people working with tbs drugs to try to duaerfbo

tho {runawork within which they
naruotic nntugonista are used.

tr! working and how the

?10Ile note the «hang: in nderSa.
ginncrcly yours.

an; 31nk,

M.D.

Profbssor of Psychiatry
Hilid

�</text>
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                    <text>73835354
February 15th. 1973
John

I.

Johnston,

Drug Alamo Informatics}: Programs,

Biological

Scum“ Communion macct,

The George Washington University Median; Center.
2891 3 331%”, HJL,
1)GC 20009.

Valium,
has:

Mr.

Johnston.

I think

mmlettor ”viewing- mgrm 1n
t aural aftert, and I m
plmud to assist you in any way that I can. If it is
not mom, 1% at least can be m, an! I wagon that
you try.
I an willing to contribute
. it you phrase
speciﬁc quantum.
a.

monthly

narcotic: antagonists would be

‘

A

mt:

an

0m 92 the things we}: I think would be useful in

mm
antagonists, their present experience.
motto
etc. A amend

only lune in

States using

o. 1131".

of the waters tn the

drugs used,
effort might be to as): ml:
of the people working with tho drugs to try to describe
15120

within
W]:
autumn“ are and.

narcotic

which they are working and how the

Please note the charm: in

wars”.
aineemly your: ,

Max

Fink, Md).

mresmr of Psychiatry
WI 13

�</text>
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                    <text>Juno 3, 1972

T0:

Billie Jones,

FRDH:

Max

SUBJECT:

Freeing of ﬁrs.

M.D.

Clhnical Director
Fink. H.D.

Thomas From 15A

On my return from a trip I find
Mrs. Thomas from 15A to another service

that you have tranaforred
at ﬁetropolitan ﬂoaﬁital

at a higher salary. effective immediately.
I

am

pleased that you think so well of

staff to seek her services, for I

know she

a member of

the

ISA

is capable. I even ooro

dolightoé that you ovaluato her sarvicaa as worth about $5,000 more
we are paying her.
I have indicated to Mr. Schwartz, on prior
occasions. that the staff ware grossly undorpaid, and your evaluation
than

confirms

this judgmont.

While I am grateful for your confidanco, I am aware that
Mrs. Thomas is directly roaponaiblo for patient care. until we
have an adequate roplacaonnt. I have asked her to continue to oervo
15A. I know that you will agroa that bar promotion in work duties
ahould wait upon a roplacanant, for otherwise tho patients will
suffer a loss of care; but that Mrs. Thomas does not suffer for her
unuaual capacity and rocogniaing your judslant, I am asking ﬁr.
stowartz to pay her new salary ottoctivc innodiatoly.

Again, I thank you for your confidant. in our

cc: 1.

B. Schwartz
Mr. M. Thomas

or.

x. Koanick

Dr. R. Levine

staff.

�</text>
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                    <text>January 21, 1954

Dr. B. Sherwood Jones

Director. anartmnt of radical monarch
mister: Empire}.

Nr. Proooot,
England
Dear

Wm

m. Jonas:
Dr.

J.

C. Holden

in an appoinmrt as

W

of Lanoaohirn has indicated an intercot
Imtitute
psychiatrist at the

mom

ofPoydaiatry. Thio clinicalmoearchandtrainingmterhas wits
pmncipal forms studies in the sum morally ill, and mines both
clinical and laboratory program. Laboratories in

31th.
scrim

elnmcemphalogramy. clinical psycholow and computer
are my: operations].

I world be grateful for your opinion mgam‘ing the 1mm
abilities of Dr. Holden, as well no your ootimatn of his ability to

participate in collaborative monarch.
Many thanks for your coopemtim.

Sinmrcly yours .
Max

rink,

Director

Mf‘mlg

M.

D.

�</text>
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                  <elementText elementTextId="106552">
                    <text>.:-v.-

7‘;-

"-7"

1pm..“

war.»—

aFug-UV»

-

.
.,-.

,

t1‘&gt;&gt;vnr7'V1'l

w

9“,,

Deceﬂbar 25th, 1972

“a:

a
-_.

1-,W—«w.

Mt. Kevin Jones,

Facilities Planning Offica,
Administration h38,
6UNY,

Stony Brook.

Dear Hr. Jones,

behalf of the Dapartment of Psychiatry and my
associatas ax Internaticnal Assoeiation {Or Psychiatric
Research, I want to thank you for yQur excellent
recommandations. both as to aesign and as to the contractor,
and for your guidance in renovating the EEG and computer
facilities in the departmant at Surge I. I have been through
renovations before, and man recall no previous occasian when
the planning and renovations want 30 smoothly and so well.
On

.

w

-f$','_‘W.‘0\'—:‘r

Please accept the enclosed
My

gift

on our

behalf.

very best Vishnu for a successful 1973.

sincerely yours.

Fink, M.D.
Profeaaor of Psychiatry
Mix

MF/iJ

Enc.

�</text>
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                    <text>rum”

"'mlrv-“wﬂy—arum

-

a... ~v—w.n—-.w~-&lt;

October 9, l968
Dr. Reese T. Jones
Dopartment of Mental Hygiene
The Langley Porter Neuropsychiatric
4Gl Parnassus Avenue
San Francisco, California 94l22

Institute

Dear Reese,

mr—aw

dawn-nwm'

.m—s

Please excuse the delay in answering your letter, but I
that I could handle additional tapes. I believe

had to be sure

that

I can.

1 have read the draft of
your medical student's report
EEG
examined
records carefully. The record of
the
ano
S. Miller showed very little change except in the samples
which follow flashes. But those samples are too short to
be sure.

shows a decrease in alpha abundance
and
an increase in beta and theta activities.
and in amplitude
I read these records before seeing your letter and wonder if
your statement that Shiel's record showed little change may
not have been in error.
The

record of Shiel

-n~—-;;.www.

As I

showed you

at the meeting.

we

are prepared to provide

print-outs of the EEG samples. statistical changes if the samples
are sequential. and figures of the EEG changos for each of the
variables analyzed. The analyses can be either of period or
power spectrum.

Trwvw-ﬂv‘uﬁ‘l'

&lt;

wwnpw

.4-

raw-rarw-nvu-

quality of your paper record is excellent and we will
“artefact” the saMplos during playback. Assuming that you will
provide multiple drug administrations in the same subject and
that you will randomly assign the sequence to take care of
the sequence effect. and. ideally that you will throw away
the first records in each subject. I would ask that there be
a 2 minute sine wave followed by a minimum lo minute resting
record. To maintain a constant state of alertness during this
part of the study. we introduce eye opening every 5 minutes.
The

-

.- ..../-—1-

.

..~.,~

”.3.—

�D" “"95

-2~

October 9, 1968

Following drug administration. at whatever times you
feel the effects are to be measured, we would need a 15 minute
sample done in the same fashion as the pro sample. You may, of
course, record additional 15 minute samples in an experiment
after administration. It may be worth—
at. say, 1 and 2 hours
EEG
while to take an
sample before your interviews. and again,

either after the interview or the flicker experiment.

not know if we can read your tape and would suggest
manufacture
a 10 minute sample with a different frequency
that you
We
read each one and if the frequencies
will
on oath channel.
them
come out as you put
on, then you can proceed. Re are equipped
3
l
back
to play
at 7/8, 3/4. 7 1/2 and 15 ips. Most of our work
1
is at 7/8. I would suggest you record your sample either at
1

this or

do

3 3/&amp;

ips.

that we provide is a “relative“
amplitude. it is important that the calibration signal from an
oscillator go through the EEG and that the settings of the EEG
not be changed thereafter. If you will ”lock“ your calibration
amplitude to some standard, and although it will very, it will
Because the amplitude measure

do so within a narrow range, and thus give you a good amplitude
measure.

for us
itofeasy
the same

to identify samples, we generally
frequency at the end of the experiment
place a signal
1 minute.
then leave a gap of approximately 2 minutes on the
for
tape and begin our next sample with a calibration frequency not
easily related by a factor of 2 to the one before (gég;, 10, 17,
25, 8, 20. £32,).
To make

Incidentally, in reading the medical student's report, it
seems that subject A had no EEG change, D had an intermediate
change and B and C had the greatest EEG change. Hhat were the
behavioral effects Just before and just after the EES samples?
he will begin our THC studies within the next two weeks.
I have not yet received a legal supply of marijuana but plan
to carry out the study anyway. The protocol is being retyped
and I will send you a copy as soon as I have it.

Please send us

a sample

tape and he will proceed from there.
Sincerely yours,
Fink. M.U.
Professor of Psychiatry

Max

MF:kp

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                    <text>November 26, 1969

Dr. Reese T. Jones

The Langley-Porter Neuropsychiatric
401 Parnassus Blvd.

San Francisco,

California

Clinic

94122

Boar Reese,

Following is a summary of our analyses of the

hﬁﬁ

analog

tapes submitted earlier this year. Separately, I am returning
the analog tapes. Xerox copies of the data sheets are enclosed.

first

checked the analog signals and because of
in
peak-to~peak voltages, re-wrote the input
differences
Each
record was then processed as a continuous
programs.
record using the period analysis program, with 320 samples/
second, 20 second epoch lengthcs, and frequency bands as on the
report. Three records by four subjects were satisfactory.
Our initial review of this data showed considerable variability
for each drug condition. The summary data of that analysis
was sent with Noon Galloway earlier.
We

We thought that power spectrum may yield better data
and repeated the analysis of the 3 records of Harris
using our power density program with 50 lags, and a sampling
rate of 100 samples/second. The outputs were compared to the period
analysis and the data was so similar that it seemed unnecessary

to repeat the remaining records.

Concurrently, we were analyzing other drug induced EEG changes
and we became concerned that the continuous analysis may have
lost some significance because the sample size was too large.

then re-analyzed the continuous record into 3 minute
epochs (samples still 20 seconds in length) with means an&amp;
sigmas for each 3 minute "sample“. This data seemed more
rewarding. so we "artefacted" the records (deleting those
20 second epochs that contained more than 2 seconds of eyeblink,

We

movement,

etc.).

�Dr. R. T. Jones

.
.

we...

..
w

,,,..._,.,;,..‘

../...,-w.....

.-.~,,..W—n

u,

_.
.

,v
_—.

November 26, 1969

~2-

means and sigma for each subject and each
Based on the pro—drug sigma for
calculated.
trial
each variable, we calculated the change in number of sigmas.
This statistical maneuver provides standard scores for drug
changes in relation to the stability (or variability) of
The

pro-drug

were

the subject's pro—drug record. lhe means for each drug
condition across subjects was also calculated.

The data was anaiyzed by regression analyiij. For
the sample available, only one of the regrcscinn cochicients
was significantly different, that of delta for irug 3 (tarijuana).

amp—rt"

.,...

4»

era-when“.

Nevertheless, we projected another analysis comparing
the drugs in terms of the regression coefficients and intercepts.
The slopes of the drug changes were not different between
the drug conditions, but there were many changes among the

intercepts, particularly for differences

-

.uav-vrrwr'lw/

placebo, and
placebo

.v,»

.

7....1.

m"...

and

less so for alcohol

marijuana).

and

between alcohol and

marijuana (least for

An analysis of the pattern of regressions and intercepts
for the 20 variables of the study was also carried out, by
calculating correlation coefficients. There is little similarity
in slope or intercept patterns except for the slopes of marijuana
and alcohol (+0.92) suggesting that these have similar effects
on the pattern of EEG variables.

At this point, we conclude that analysis of the analog
signals from your laboratory is feasible; and that the period
analytic and statistical programs are operational, For this
specific project, few differences between the two drug conditions

(marijuana and alcohol) from placebo are observed. The
differences were in the rate of onset of the changes
in some of the EEG variables, particularly between alcohol
and placebo. The degree and the rate of change were not
discriminable.
few

m

.
r.”

.,:V..,,vqm

”a

..

,.,.-

,,
w”;-

actrmwuq—u

In".

The reasons for the failure to identify differences
are potentially many:

1. There are no differences in EEG effects of
the drugs in the dosages or subjects used in this study.

�Dr. R. T. Jones

November 26, 1969

—3-

2. The changes are varied, with different time
courses and degrees of change so that for this small 5 mple

(4 subjects) a consistent pattern did not emerge. Contributing
to the variation in samples were incomplete artofact control,
lack of alertness control, and the short length of the period
of observation. The artefact control was hampered by the
unavailability of the original strip charts with an observer's
notes. The alertness control which we are now introducing

is

a buzzer task which

alerts the subject

as sons 15 he

inadvertently releases a hand held, spring~loadod kcy a
release which is associated with drowsiness and sloop induction.
~

in the marijuana sample may be ”real“, and
would suggest an expansion of the number
of subjects submitted. If this is not feasible, and the study
is repeated or expanded, the EEG samples may be analyzed more
rapidly and we would suggest the following small changes in
the program:
The changes

for verification we

IQH

a

3.

Introduce an alertness task
recording should be done with
better control for peak-revpeak amplitudes.
Submit strip charts with tape.

EEG

you have compared these notes to the data samples,
visit us to review the procedures to
answer the questions you may have.
When

perhaps you would care to

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:kp

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                    <text>«~/

August 5, 1990

Reese T. Jones, M.D.
Langley Porter Psychiatric Institute
401 Parnassus Avenue
San Francisco, CA 94143
Dear Reese,
Fritz met me at the cafeteria on Friday and shared the story of your
dilemma, so your letter was not a total surprise. I am delighted to write a
supporting document, and attach it to this note. I will send these by Fax, and the
original will be sent directly to the committee.
Yes, Fritz has ’eliminated’ an ECT Service, and yes, he thinks he is
Jesus reincarnated, and he does not realize he has taken a first-class department
under Stan Yolles and created a pseudo-neurosciece program with hardly a single
psychiatric redeeming feature. No wonder our resident applicants are mainly from
off-shore schools.

But the elimination was accompanied by a substantial raise in my salary
and no additional duties, so after being upset for a few weeks, I have settled
down to treating my ’private’ referrals. The shift gives me a chance to look, once
again, at my pharmaco-EEG experience, an experience which I have neglected for
some time in favor of ECT.
I hope the letter is helpful. Let me know if there is more that I can do.
My regards.
Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

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-‘
'

7383-80783

11 December 1973

Federation of American Scientists
203

Street. N.E.
0.8. 20002

C

Whahington,

”xv-"mum“

Gentlamen:
m

"Wm-

I

would

Good

like to resign

from membership

in the

PAS.

luck in your efforts,
Sinceraly yours.

War

,_,,m-..wrm_

Fink, M.D.
Professor of Psychiatry

Max

:

MF/cis

�</text>
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                    <text>Hf.

r.nmw._v--,=...».w,.v

m. ..

“Va-mm “4-,"

w."v‘puv-

mm‘=‘r=u&lt;'wv"‘?'m

---ﬁ'.":r:' w-vvr

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,

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xvii-I"

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w

www

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w"‘!‘.—WNW

WA-vwr-

q..-

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73SB~806SB

_
—

11 Doonmbor 1973

Horvoy Blnootono. M.D.
Chairman, Finance Committee
American Psychiatric Association
Council of New York Stat. District Bronchos
420 East 76th Seton:
Now York. New York 10021
’

Dear Harvey:

Euclooed is a check in the amount of $500.00 from Mr. Sidnny
Gimpol on bohalf of Sandoa-Hondor for the 197k divisional wanting.
I would be grateful if you would acknowledge recoipt directly to

Mr.

thpol.

I reztot thot I could not nttond the matting of
I trunt ovorythtng to woll.

Beaumont 11.

Sioooxoly yours.

-

«ﬁavve-vvww

ﬂax Fink, H.D.

«v.

,

Yrofosoot of Paychiotry

(wuuw.

MF/cis

,wrkgg'm

.

.
turn-W

Tm».

“C1

0

1‘

-'

'

'

‘

v

'

‘

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"'7‘"-

�</text>
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-

"mix"

October 17, 1983
Billy E. Jones, M.D., Director
Department of Psychiatry
Lincoln Hospital

234 East 149 Street
Bronx, New York 10451

Dear Dr. Jones,
I regert that I am unable to accept your kind invitation to present a
lecture to the staff of Lincoln Hospital. I will be unavailable on the date selected.
I recall with pleasure the lecture I gave in 1980, and the interest of the
staff in so controversial a topic as convulsive therapy.

My best wishes for your success

at the College.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>w.

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March 14, 1977

J. Eric Jordan,

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DearDr. Jordan,

Webacamintmstadinﬂmmlatimsbemﬁm

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activityofvariws
wiﬁubmaodhmhxewdhzepmandbmampm~tobefoﬂamd
profiles, blood levels,

latelybysuﬂiesindipl‘mylmdantoim'mediazqmblmd
levelswemdcuby

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mmﬂmbeirxgwrittanm.
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atbloodlmlnabave7mcgbutmthelmv. 'matstxﬁyiain
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Idomthmofotmrsintemstedintrﬂsvmkatr

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mmymaremtmquork,maﬂvisitarﬂm

mnelmyaumtmhaveﬂme.

Sincerely yours,
Max

Fink,

PLD.

Professor of Psychiatry

CPI, 20:184-191., Aug, 1976.

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