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                    <text>January 26, l968
Dr. Harris

Lexington. Kentucky 40506
Dear Dr.

acetylmethadol or compounds like
Many

sir—v4-

thanks!

Fink, M.D.
Professor of Psychiatry

Max
r2.

”nun

it?

Sincerely yours,

4-

w

lsbell:

In the course of our studies with addicts we, like others,
have tried methadone maintenance. In a communication from
Dr. Paul Blachly, he indicates that you have had experience
with acetylmethadol - "slow dope." Can you tell me if your
experiences have been reported? what is the availability of

7-

wy'rvvwrm-u

Isbell

Professor and Acting Chariman
University of Kentucky
College of Medicine
Department of Medicine

MF:kp

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                    <text>vxtww’ﬁh-Kvxwwc

Department of Psychiatry

September 14, 1972

Harris Isbell, M.D.
Professor of Medicine
University of Kentucky
Lexington, Kentucky

Dear

40506

Harris,

Our studies in Greece have progressed to where we have
written demographic reports for NIMH but have not condensed these
for public presentation. We are now administering hashish, marijuana,

and THC—delta-9 in cigarettes, with a THC-delta—Q content averaging
140 mg., and recording the physiological and behavioral
effects.
These data are being collected now, and the data collection should be
completed by November.

w.

W

w

'0."—

.,

Enclosed are some reports which may be useful, including the
cannabis psycholis, which has been published.

.
,7,

V..."

,,
7v:

&lt;wymv

Sincerely yours,

N'va’vﬁfﬁtﬂ-"vvm—r'w‘

..
,.

my»

"aw-w-

r—‘vn—

www—W

.w-

-w-vm—w—

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“Wu-”W.“

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Max

Fink, N.D.

Professor of Psychiatry

�</text>
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                    <text>Deconbor 9, 1971

hirooni Iohlzakl, 5.2.
Instructor

M.D.

Doparrnon: of Neuropoychiotry

Knnooi Modicsl School
Oooko, Japan
Door Dr.

Inhizoki:

I regret that we are unable to process any opplicotious
for positions in EEG rooearch at the present time, and trust you
will be able to find a position in Germany or the Soviet Union ~
both countrtloavhioh are actively seeking students.
Sincerely yours,
Ha: Fink, M.D.

Professor of Paychiotry

HF:13

�</text>
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Augult 25, 1969
Mr. T.

J. Israel, Jr.

Vandcn Brooch, Licbcr &amp; Cal
125 Maiden Lane
Now York, New York 10038
Dear Tod,
would you please confirm directly to our auditors,
Pancth, Hubs: and Zimnorunn, 135 East 42nd Stroot, New
York, How York 10017, the following information as of

June 30, 1969:

1. Security position,
2.

My

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fund: due you and due us.

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is enclosed for

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Sincerely yours,
Mu rink, NJ).

Exlcutivo Director

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,

-1

0
DUTIES OF EEG PERSONEL

Kasper, Mary Jo

w

'

l.2.

Supervision of EEG department.
(50%)
Schedule and supervise investigations (esp. LSD-25) and rating.
3. Interview and rating of out-patients.
h. Graphing research material (15%)
(25%)
5. Order EEG supplies-~1ncluding pharmacy, laundry, and Central supply
6. Reading EEG with Dr. Itil (10%)
Dierker, Betty
.

.

(hWF’WNI-J

.
.
.
.

Co-ordination between EEG and wards (5%)
Schedule and supervise acute investigations (esp. Pentothal, Ditran)(30%)
investigations.
Interview and rate patients before, during, and after acute
(5%)
Dr.
Keskiner.
with
weekly
Check medications of patients
changes (5%)
Attend daily rounds and rate patients who exhibit behavior(25%)
Assist with pneumoencephalograms and after-care patients

Klingenberg, Helen

1. Recording of resting and acute investigations
2. Responsibility of Grass Laboratory
3. Marking, labeling, and filing of own recordings.
Davidson, Dorothy

1. Recording of resting and acute investigations
2. Responsibility of Offner laboratory
3. Marking, labeling, and filing of own recordings
Galloway, Charles

1. Operating tape recorder
Mo

on Grass during

acute investigations

(5%)

an, Gloria
Schedule appointments and meetings

and typing of letters, publications, and meeting minutes
(7 items)
Control and balance of EEG dept. budget
Organization and filing of literature

Dictation

Supervise volunteer secretarial workers
Order office and other supplies for the department.

June 29, l96h

(30%)

�-2...

Gig , Yulmen

1. Design of research materials
2. Measuring and graphing Pentothal, Ditran records
3. Assist Dr. Ikuta with evoked potential 50% of time

Itil,
.

.

mmﬁ'wNH

.
.
.
.

Ellen (part-time)

Co-ordination between x-ray department and wards
Schedule patients with Mrs. Dierker for pneumos., skull and spinal x-rays

Technical assistant for pneumoencephalograms
Spinal fluid analysis
Measuring and graphing of ventricular system
Bibloigraphy for penumo. and spinal fluid investigations in psychotic patients

Frielich, Natalie (part-time)
rating of patients: a) personal history b) family history
c) social history from chants, patient interviews, and family interviews
2. Certain psychologic tests in in-patient jCintelligence tests, etc.)
3. Prepare bibliography concerning the relationship between prognosis and
personality, social, and family factors in schizophrenics.
1.

Summary and

wright, Lucille
1. Recording clinical EEGs and typing reports
2. Tune analyzer daily
3. Take EKG from 2-h on wednesdays and Fridays
Kettman, Gene

1. Technical supervisionend repair of equipment of
2.

MIP

Building new equipment

Earll, Pat
1. Take shorthand and type research EEG reports
2. Take dictation during or after acute investigations about patients behavior
by Mrs. Dierker and.Miss Kasper
3. Type for Miss Kasper or Mrs. Dierker
h. Take shorthand and type for Dr. Holden
5. Take shorthand and type for Dr. Ikuta
6. Help Mrs. Morgan if necessary

June 29, 196k

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                    <text>‘September 17. 1965
a

Tureu

clo

ltil.

K. 613

H.D.

Topkepi Satay
Istanbul. Turkey

Deer futon:

for your letter from Stuttgert end for the
slides.
I returned to St. Louie, I found the program running very well. Everyone seemed quite content and I wee moot
pleased with the progress that occurred during the month of
Ansuet in the laboratories and nice in the petient studies. As
for specific questions and problems, I will ehere some of these

Thank you very much
When

with you and none of the decieioue which I have made.

butepereeine study is good. and I reviewed with Ali his proeentetiou to the E.GiD.E.U. group. Instead of making up slides,
he will make up a number of tables and will have these winner
graphed for presentation to the group.
The

etudiee of pentothel activation are running well.
10 day interwele, six patients receiving
and
triﬂluperidol,
I eeked Ali to give Mrs. Dierker three names
of petiente receiving butepereriue and three patients who V111
receive thiorideeine. These twelve petiente should receive
peutothel EEG: and computer analysis about every 10 days until
each one hes had six to eight measurements. These will be taken
during the drug—free period and then while on a drug.
The computer

,

we

will be following at

.

study is in progress. I reviewed the one record using
the computer in which you have pentothel eetiwetion. To my eye,
this did not help the discriminetiou. Two of the volunteers have
been done, but one in Mrs. McDonald. who he: been pregnant end I
think this series will not be «petal for us. Charlie is able to
do two recordings e week.
The SKI

I reviewed your protocol of EEG computer study of different pheno—
thielinee. Richardson could not start. end Ali suggested Tucker
instead. The protocol is eetieieetory except that I would like to
add on examination with trifluperidol end one with librium to
bring the group to six. I am rewriting the protocol and will eend
you e copy es soon as it is ready. Will librium et.l mglkg end
trifluperidol at 0:2 ms/kg be e eetiefaotory dosage schedule?

�Turan

sept.

M.D.
Itil,
17. 1964

Page Tun

In reviewing the LSD work with Andy, it became obvious that he
has had an extensive experience. The clinical changes are re*
corded well and I thought it was important to have him start
some EEG analyses to determine the EEG criteria for threshold
and for tolerance. we began this yesterday and hopefully, dur»
ina the next two weeks, we will have some preliminary work in
this area. Would you like to suggest how he is to determine the
threshold affect on £36?

I

met with Mike Holden and reviewed the lobotomy and combined
drug therapy projects. The combined drug therapy project is
quite good, and-he has most of the patients for this group. The
initial studies are in progress. The lobotomy study was unclear
and we discussed this at some length. I suggested that the same
problem would be faced by him as Andy faces. mainly the determina-

tion of the differences in

LSD.

Ditran sensitivity for the
will discuss this further.

lohotomy and the non~lobotomy groups. we

Magrinat began this week with Ali, and in principal, I accepted
your recommendation that he participate in the study of epileptic
disorders. The Oapolat protocol has some questions in it which
can wait until your return. In the meantime, he is to get to know
Ali's patients and will help him so that he can spend some more
time in the laboratory.
1 reviewed some of the tapes made by Mrs. Wright and find that the
.Offner is set with time consonants which lose the fast frequencies.
Gene and Mrs. Dierker say that this has been done with your approval. Is there some reason why you wish the Ofﬁcer set so that
fast frequencies are lost? I would like to change the time con~
stants so that some of the fast frequencies will appear in the
0!£ner_rscords as well, but will not do so until I hear from you.

with Harry and Sam. The Ditran study
has progressed very well and they have an excellent clinical paper.
Don has done a good job on the statistics. We agreed that they
would prepare two reports, one of the clinical material in which
the EEG would appear simply as a summary; and a second report in
which the Ditran and lhorasine combination would he discussed at

.1 had some wonderful meetings

length. A third reports. on the EEG and behavioral relationships
will await your return. In large measure. this is because we will
have to undertake a detailed quantitative analysis of the Ditran
records and I know no good way of doing this except by a visual
analysis using your quantitative schema. While Harry will already
have gone to England, I believe we should be able to write that
report this Fall. I would like to send in an abstract to the
American Psychiatric Association similar to the one you read at
C.I.ﬁ.P. Since it has to be in befora_0ctoher l, I shall assume
that I have your concurrence in sending in an abstract of this

nature.

�Torah

Sept.

M.D.
Itil,
1966
17.

PageIThrea

Jim has oarriad out some of the biochemical studies in spinal
fluid and I have a summary of your observations on my desk.
I hope to so over these with him as soon as I havo a chance.
In the meantime. he has come to on with an inquiry as to whether
he can assuoo responsibility_for the biochemistry laboratory;
and whether we can-support or are interested in s biochemical
program about the catachol amines.' I told him that this was
difficult since we had neither the funds nor the stature in the
research world to study this type of neurohumor. but recommended
strongly that ho participate in our studies of cholinargic moth»
aaians. He has demorrod. stating that his participation in such
a program would be of secondary interest to him. After all, such
s program would be largely ours and not his, and he has to make
his mark in the world. I accepted his comments but indicated
that it was not proper for us to assign the responsibility for the
biochemistry laboratory to him since we were anxious to have s bio—
chemist.primarily of s collaborating scientist. He has agreed,
however. that the spinal fluid studies which you and be are under~
taking should be continued, and more important, that he would be

pleased to carry out additional spinal fluid studies in patients
receiving psychotropic drugs. with this in mind. and to broaden
the coobined drug study program. I wonder if you would agree to the
following associated study for Mike Holden? If we wore to collect
the spinal fluid of patients on the combined drug study during
their free period and again at various times when they receive one
or two drugs, and measured the spinal iloid for cells. protein.
the qualitative distribution of proteins. transsminese, cholinesterase, and any additional enzymes that we may be able to mossure
in our laboratory - this would he a good supporting study for determining if spinal fluid changes markedly during drug administration.
What do you think?
-

I

vacation. Please give
regards to our many friends in Istanbul. Ali sends his regards.
and the whole staff misses you.
hope you, Ellen and Kurt have a wonderful

my

Sincerely yours,
Mex

Fink,

Director
HP/Jb

M. D.

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                    <text>April 6,

Dr.

Tom

1965

11:11

Him
5300 Arsenal Street

Institute of Peyomatry

St. Innis, Wound.

63139

harm:

mieiejmtetomlnotemmindyouﬂutmmim
m’Wztioholimrglo
w amen" at the Society of Bi
.,

Paydxhtzywinbeheldmmurdayeftem,ﬂeyl,at2zaohn.
ettheﬂw‘lorkﬂiltonﬂotel.

Iwmldlikeywtopmmtywmteﬂalwithinmty
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Imoliketohmymjoinmeomygmstforlmnﬁn
MYthﬂthotelatmmrhyl, withﬁnoﬂurpuulpartioipants
soﬁutmomdiameammmtogeﬂm.

Simmly yam,
Hm:

Pink.

H. D.

Professor of Pay-wintry

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                    <text>731:109

May

17. 1973

Mt. G. C. Knnznan
IBM

59 Maiden Lane

New
,

York City

Dear Mr. Knnznan,

.v
~

"r-w-uw

4—4va

._
:w-x.

v
vw

.-—~.

V‘W';

I would be grateful for your assistance with the two
enclosed statements sent this Association for payment. In part, I
an turning to you because I seem to lack a business office contact
in Haeaau~8uffolk.

is now increased from a monthly charge
lack an explanation for this change. Last
month, we did receive a statement marked for $0.75 and the note that
it not be paid. Can we get an explanation 7
1. Invoice F276765

of $32h.00 to $32h.75.

We

2. We moved the IBM 1800 from its location at the Rev York
Meaical College at S East 102 Street on Decenber 7, 1972. Each month.

I

have corrected the invoice

Installed at:

'

"-‘

‘
“12'7"

-n-"'n'"7.‘"""-“V"‘

.m‘mm'vmwmww

The invoice address

Department of Psychiatry
Health Sciences Center» Surge I
BURY at Stony Brook
Room 2310
Stony Brook, Haw York 11790

is correct. I

these invoices before
Thank you

in the appropriate location to:

we

would appreciate correction of
take further action.

for your assistance.
Sincerely yours,

1m”

TW‘S'WW‘WM'WF

mmbwwuw

Pink, M.D.
Eeceutive Director

Max

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                    <text>TSNY:106

Elmer Gardner, M.D.
Bureau of Drugs
Food and Drug Adninistretion
Rockville, Mhrylend

De”

M8?

11. 1973

IND

5210

A1.

The studies of fluphenesine at high dosage, undertaken
in St. Louis and in Istanbul, were completed in 1971. The studies
resulted in s number of internal menorsnde describing the effects
and some EEG and behavioral reports published by Professor T. Itil
of the University of Missouri.

The studies were suspended vhen they were completed; the
supplies of fluphenezine were either completely used in
the study. or used at lower dosage in the clinical csre of pateints.
Bo stocks of high dosage fluphenezine exist.

initial
IRD

5210

this letter, I an notifying Professor Itil that the
is hereby suspended; and shall ask him to forward to your

By

office, copies of the reports of the studies for your information.
Thank you

for your oooperetions.
Sincerely yours,
Fink. Mons
Professor of Psychiatry

MEX

mf/

'

�</text>
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I think the effects of the peptides
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the

ECDEU,

I

am

as you requested.

I will be pleased to receive a
available.

handbook should one be
My

copy

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little

best regards.
Sincerely yours,

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                    <text>September 15 , 1965
Dr. Turan M. Itil
Topkapi Sassy Muzesi

Sultanahnet

Istanml, Turkey
Dear Turan:

It was a great pleasure traveling with you. than I returned,
I found Ellen and your children
quite well, although lonesome. I
was pleased to deliver the presents and Ellen
joined us for our
anniversary party.
The laboratory seem unchanged with
working quite
well. The EEG laboratory has no problemseveryone
that
except
Klingon
has had difficulties with her children and cannot workHelen time.
full
suggested that rather than resigning she wait and discuss with us inI
October a schedule of work which may be
Yulnen on a partwtim basis, pemaps she mutually agreeable. With
too can give us sufficient
help to get our papers completed.

Dm Shapiro found

a

young man

to help out with Denber's

tapes
almst caught up. (Jamie has come back from her
vacation and within a week I believe we should be analyzing the

and

this is

now

tapes as rapidly as he produces them.

George has had some problems with

his project. There are some
evoked response to threshold stimuli and at
superthresho‘ld they are less stable than I would
liked. The
double stimulator has not yet been conpleted, buthave
Hank tells me
should be ready for testing by Friday. George is in a good mood.

difficulties with the

He

By

apparently

is

an

excellent

baby

sitter.

it

Nafi is involved with his test and is
it on Wednesday.
next week he should be ready to begin thetaking
work.

Your patients are doing very well as
are mine. Ali and Jovan
have maintained the wards excellently
and there is no problem mere.

I have worked closely with Ali to bring up-to—date the draft
of the APA paper for October 9. I think
is very good and added
two or three "political“ sentences which it
can either accept or
you
reject when you come back. The maiman of the
Program Committee
called me and I told him that the paper will be sent
to him by Monday.

�g»

\

Itil

Dr.

~2-

September 15, 1965

Ali had sent notes on Ospolot to the Intercontinental. I
read the notes and it seerns to me that our decision not to send
an abstract to the Epilepsy Society is still a good one. Enclosed
is the abstract you dictated for the American EEG. I will hold it
until the 29th and if you make your corrections before then I can
send out a copy with your revisions.

is well and I have reviewed his studies with him. I
will have to spend some time about the data analysis , but that
will have to wait until the Denber problem is well in hand.
Mike

have remived letters from Dr. Freedman regarding our
chapter. I told him in New York that we were delayed by vacations
We

that he would receive a draft by mid—October.
I will have the draft for you when you come back and you can then
and the EEG meetings and

correct
and

it .

Andy Don's

.

leaving

is a great mystery.

I will try to salvage

some

I can. Apparently he spoke to no
leave of absence.

He

left

only a few notes

of the linguistic material as best as
one except George

to request a

leaVe next week but left last week without
requested the University to transfer his
grant to New York and then requested the Fomdatim to transfer all
the equipmnt bought on the grant . Since the Foundation has to
approve the equipment transfer, the letters were waiting for me .
Sam

was supposed

farewells to anyone.

to

He

I called

Mr. Thompson mid George Ulett and was both amazed and
to realize that Mr. moupsm had sent the papers through
University without George '3 sigmature and that George was

saddened

to the
willing to let it all go. I pointed out that the Institute needed
both the funds and the equipmnt, and that your studies alone on
Ditren and anticholinergic drugs, let alone mygom part warranted
the transfer of the grant to either one of us. I reminded George
that the Institute has the right to request the redesigxatim of
principal investigators. By this afterncm, the only thing I have
heard is that George has asked Korol whether he needs any of the

that he will probably save a few bits for him. ,
The Dorsey people will be here on October ll. I have written
to van Gogh requesting the return of the letter of credit and when
we get it, you will be free to use the
may either for an Echo~EBG
or telemetry or even another trip to Europe.
Take care of yourself. Hertha has seen your other gifts for
Ellen and she would like gery much for me to break my word to you
but I won't. Have a good time and I will see you at the end of
equipment and

the

warmth.

Sincerely yours ,
Fink, PM).
Professor of Psychiatry
Max

MF:kp

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                    <text>January 19, 1986
Dr. Tumn

Missouri

M.

Itil

Institute of Psychiatry

Arsenal Stmet
St. Louis, Missouri 63139
51400

Boar 'I‘umn,
Dr. Bradley we!

I

m pleasedto mnfim the invitation for

your participation in tho symposium on Anticholinorgic Hallucinogens
at the formoaning mating of the GIMP, to be held in Washington, 0.0.

on March 29 and 31. We look forum to the pmsontation entitled
"Behavior and E133 Comlatime after Anticholinergic Hallucinogena
and their Intamotim with Phenothiazines and other Hallucinogens."
As than are
a few questimsobout the ”ability of some of the
Eumpem invitees to attend the meeting,
will be a few weeks
befom we om send a definitivu program and tim schedule.

still

it

Five reports will be presented during each three hour session,
alluring ﬂirty-41% minutes for each pmsentation and discussion.
Since the disamsion my be of special interest to the participants.
mmportahwldbcabwtzo minutes inlength.
mo CINP has pemitted m to wider the publioation of this
smooiun separately. Insofar as this subject is becoming
inmosingly importmt, we believe that the association of the
work of tho participants in a single volm will be a valuable
omtribution. and ask your cooperation in making a manuscript
available at the time of the meeting. The moript should be

approximately 20 pagaa of

text; plus

bibliography and

illustrations.

Since we would like to print a prom including
for distributim at the meeting, would you favor me byabstracts
a single
pmmph or two describing your maxim?
.

We

look forward

to yam panioipation.
Sincerely youm ,
ﬂax Fink , M.D.

Professor of Psychiatry

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                    <text>Octdbdt 12. 1966
Dr. Enron H. Itil
Missouri Institute of Plyohintry
5400 Araanal Street
St. Lenin. Hinuouri 63139
Dear Turin.

I boiiovo it would be oppropriata for us to
the fluphenazine decanoatc material at
present
the ABM? mating
you. I will be vary glad to
If aggroublo toassuming
that Ali will present
an
write
abstract,
n

o

it; or if
will
.

he

is unavailable. that either

you or

I

Perhaps you would consider a concurront
presentation of our cyclouorino symptom provocation
have had an
studiol. for by that tins Jovan will
month
followbup.
tho
six
complete
Opportunity to
It was nice being with you in Donvor and I
look forward to seeing you in Whihington.
Best regards to the famiky.

sincoroly yours.
Pink. Min.
Protonaor o: Payohiatry

Max

erkp
P.8.

Tho

boat reservation for washinqton on Monday.

air shuttle. Ank for an
open dhuttlo ticket and u. can arrnngo to go
on the Inn. flight.

October 24. in tho

�</text>
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                    <text>October-28, 1966
Dr. Tman

Itil

M.

Hissomi Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
‘

Dear Turen,
Enclosed is the galley proof for Ccmprehensive Psydﬁatry.
I have read the text and found very few errors.
For reprints, please order 100 with covers for me. I
wouldsuggestywcallDr. Taborandorderasmanyashe.
wishes, in addition to those for Ali and yourself.
Add
47.....-

«

Under authors

yams and
Again,

V

identification, Kathy has typed in

Ali's.

my

my own.

best regards.

37—10”

Sincerely yours ,
‘Wndlﬁo‘niwyﬂhr-P}

a—v

Fink, M.D.
Professor of Psychiatry

Max

m—

'."P\.

x
n

wvaz-w:wav=v‘

rrrrv

“w-W-

”1ka

�</text>
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                    <text>-

—v,

October 28 , 1966

,.

«t

-._.w_....-..W—.r'.—www~..er

Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
.

Dear 'Iuran,
Enclosed is the manuscript of the delirium paper with the
corrected references. Not only did we correct those marked by
the editor, but there were two or three additional ones that
were no longer in press. We have corrected the text to show
the new reference numbers. Rather than increasing the number
of errors by ‘retyping the whole text, I believe it is sufficiently
clean with the corrections to be easily handled by an editor.
Secondly, I am enclosing a final copy of the digital computer
paper which has been submitted to Drs. Kline and Laska. The
proper citation is as indicated in No. 20 of the list of references
in the delirium paper.
EEG

-

Don and

I went over the

SKF

material. There are

numerous

criteria which distinguish drug effects! Cong'atulations! The
next step is to graph some of the present data and then to select
those criteria which are most general. If these make sense to us,

will then carry out a discriminant function analysis for three
sub-groups: barbiturates and placebo; stimulants and placebo;
barbiturates and stixmilants.

we

I

am making arrangements

Saturday, November 11 and 12.

to visit with

you on Friday and

to Jovan, with whom I spoke Wednesday afternoon,
arranging for the Chairman to write him a letter of appointment and if this is satisfactory to him, he should feel free to
discuss it with you and Warren.

I

am

With regard

In discussing the APA demonstration, Don felt that it would
take twomonths topreparetheprogrens. Iwouldlike tomake
the demonstration especially, if NIH approves the present applica—
tion; waver, I would like to do nothing until after November 20
and if I get a positive reply, will then ask Don to reprogram at
Washington University. He tells me that he will not use the NIP
staff and that this programming will not interfere with the MIP
operations. However, I believe that a most inwtant demonstration

�Dr.

Itil

October 28, 1966

~2—

be the classification of sleep stages and would like to spend
with you on this problem dwing my next visit. With
time
some
regard to support for the denmnstration, I believe it will probably

mild

cost $5,000 for progranming, $3,000 for incidental expenses like
personnel to attend
printing and artistry and a minimum of $1,500 for
be obtained from
could
of
some
this
Detroit.
If
demonstration
in
the
prmnaoeutical concern without interfering with any of our other
relationships, it would be helpful.
Finally, I am sending you the micaﬂﬂvitae of Dr. Andre J.
Angyan. He is a personable Htmgarian with considerable experience
in nemophysiology. If there is a place for him in your program,
I am sure he would be willing to visit with you.
mclosed is a short abstract for the ASMP. Please correct it
and send
My

it on.

best regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

111ka

�</text>
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                    <text>November 17, .1966

Itil

Dr. Tim M.
Missomd Institutecf Psychiatry

Street
St. Louis, Missouri
suoo Arsenal

63139

Dearmran,
Enclosed are sane odds and ends

foryour inﬂammation,

including a com of the editorial in the J.A.M.A. which you
nothave seen. Enclosedareammberoftear

mmmmmm.
"

receive than.

may

'memprintswillfollmwlunI

Please edittl'eDenberabeu‘actand’retum ittomefor
the Societyof Biological Psychiatry. Ihave sentaoopyto

Dr.DenberasIell. Wmldyoumaleupyow‘I'RPabsmct?
ItavecalledDruBonatoandheissendingthebehavioml
data to the Institute early next

week.

I have spoken to Bill 'I'umer‘mgarding the Dilantin study
and the
am. They are particularly interested in the

We

effect of Dilantin in out-patients, neurotics and psychopathic
states. When I described the adolescent population available
toyou, Bill'rmmrthoughtthiswasvezyinteresting. The

Dilmtinmeetingwillbepartofthemanduilltale place

at 3:00pmonDeoember7. ItisanOpenmoeting, andIbelieve
weshouldplantogo. IaskedBill'I‘tmxertomngeameeting
with the appropriate people after the presentations, if they
were interested in supporting the study which I had described.
Ifyouwishtobringymmslidesandprepareadiswssion, Bill
drought that

it might be useful.

IoanmngefortlnticketsyourequestedifIlcmthe
airlinetobeusedonanypartoftheu'ip.
IhavebeenovertheECDEUmpor'tsandthedissociation
mtwillmedmtimwithboth, pmbablysending
than to you by Monday.
paper,

My

best regards.
Sincerely yours,
Fink, M.D!
Professor of Psychiatry

Max

MF:kp

.

�</text>
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                    <text>November 22 , 1966

Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
SMOO Arsenal Street
St. Louis, Missouri 63139
DearTuran,
Enclosed are xerox copies of two

today. Mirsky's

I

would

asking that

is self-explanatory.

which

I received

like to answer Dr. Cattell affirmatively. He is
provide between $200 and $300 for the publication

we

of this report. Wat

be

letters

do you reocumend?

As you usually say, I hope that each day continues to
better than the day before!

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
’4
3“

«:T‘f

-:':“’

::
'-:‘"41;"

”win.

.ﬁgﬂnu‘ﬁﬁwlw

5”!"
=;.~

m3:t:=€=:*~"é"*’i"‘:'*“‘.‘t&lt;'-

13W:

57’4"

Mmrzww‘ﬁ‘

W“

k-

141’:an

�</text>
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                    <text>December 19, 1966

It” of
WInstitute
Hiami
Wm
W.

No

suoo Ammo].

‘

Street

St. ‘Muia, Missouri 63189

Dear Enron,

Iravemadthepmtoooloftmpmpoudthiwiminem

diphanylhydmtoin study with great interest. This is an
importmt stuiy am I think the asthmatic: of controls. ms

of patients wide: the basis
witwia and mm assigzwt
which may be
"

for a definitive smdy. I have fmr questions
useful in clarifying the protocol. These are chiefly in the
direction of cmifioatim but do not mdify the study at all.

‘maoritwiafow-agommazmmlitiesmmtcm.

SinestMEBGismxdergoinﬁolmge-withagemtm

www.mmmmmmmdafmwm
Emma
W
mwitwion,doesitmantmtpatientsmodonotravean
Ifoo,perhapo

populations equated for age as the single most importmt variable,
With regard to the
capacially fort):

mmwillboemlxmdfmntmnxﬂy?
atlmttwolengthymomdimsstmldbedonesotkatthis
criterion in the ample can be adequately definod.

Isthdmutimofthastudyadofinitemortobeclinically
define

it possible to
aixornimmonths?
either
four,
aniniumtmatmntpcriodof
Justuthoritwimﬂntapationtmmtbogivcnotherdmgs
for now than fivo day: an automatically mludod is a definite
radiation for
om,
maths thwalyokwldalnobemlmdfrmtmnudy.
omission is a definition of the
Tho single most
Sinoeymhwcaspocifiomimsoalo
witorin'foriwmrt.
for Wﬂnlogionl aspects, would it not be helpful to damn

detaminod by the youth cantor director? In

1033me

meatimtmmived

Wt

intrnpmtoooltMMtwintobauudfwthedcmeofomnge?
in

W,

These possibly should include

poyclmotor activity,

diammotiomlity.
We

altmtiom. in
opiaodic

and

�Dr. 11:11

-2-

December 19, 1965

Finally, the dose of diprmmylhydantoin is smoified as
this may be too low. Surely these adolescent subjects
are able to tolerate 300 mg and this may be a more effective dose.
Also, the thioridazine dosage is given as a range of 75 to 200 mg
madthisstxmldbemadecleamr. .Isthedosageaminimmaccozdhg
tohodyweight? Isthereamaxixmntobegiven?‘
200 mg and

'

'I'headditionaltrmght,vmich1amsmeymconsider~ed,is
that of sleep EEG's taken prior to treatnent and perhaps at the

end of three or six mnths. This may provide special information
regarding fourteen and six positive spikes.

I wenelosingan additional

carbon for-Dr. Turner,
may be helpful.

event that you believe these caments
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MFﬂcp

-

inthe

�</text>
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                    <text>January

A

-

Dr. 'Ihmn

M.

23 , 1967

Itil

Missouri Institute of Psychiatry
51400 Arsenal Street
St. Lwis, Missouri 63139

”w'wr‘w-W-w

Dear

wwqw...”

Man,
I have checked the files regarding the status of

_

PIE-11380.

Atthetimethatmerxiedthefirstyearmderthe
Mr.

University of Missouri,

'mompsm cracked with

the University

aswellasoxmownbooksinordertoavoidthepmblemofa
carry-over. Mr. Ttmzpson, on Member a, 1965, requested an
adjustment in the expenditures in order to fully utilize the

first years
.

funds.

If, at this

time the university claims that

mys

Psi-3.1380

is

over-expended because of
returned to the
this is largely due to the inadequate bookkeepinggoverrment,
practices
of the University, for Mr. 'I'Iunpscn repeatedly requested a
proper accounting so that these adjustments muld be properly
made. It scene, that the Public Health Service had no choice
but to accept the University-s booidceeping and so they cannot
be held aooomtable. Mr. Trumpson was unable to‘do more than
accept the University's bookkeeping and he cannot be held
‘

acoumtabls.

.

It is my View that

the University is accountable and an

~

effortmightbemadetoasktrmtoasktteUniversityautlnrities
from
to make
a correction

Good

muncmnbered funds.

luck!
Sincerely yours,
Fink, M.Di.‘:
Professor of Psychiatry

Max

Mquo

�</text>
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                    <text>January 18, 1967
Dr. Tumn

M.

Itil

Institute of Psychiatry
Mismi
51400
Arsenal Street
St. louis, Misscuri 63139

Man,
IMdlmehwithDr. Btm’ellofSandoztodaytoobtain

Dear

supplies of placebo for our out—patient department studies.

He is very much interested in studies of IT’S-23 in the
mintmance of alcolwlics on an alt—patient basis , but would
probably also like to see some additimal studies in in~patients.

telling me of his interest in Sandoz International
the Istanbul study. He asked me questions and
when I told him that Dr. Polvan was caning in the late spring,
he offered to invite him to Hanover to give a talk thereby
contributing to his swport.
I also nantioned to Dr. Freedman that Dr. Polvan might be
and

(1er

He was

I

caningtoNewYorkandhetoowillarmngefm‘atalkand
_

hmomrimn

~

if you think it advisable.

Following our discussion I have asked Kathy to nuke flight
reservations for Friday morning January 27 and will arrive at
11 o’clock. Would you ask Miss Johnson to
the Institute

m

pleasecallmeoftl‘nﬁntelsfwamanforf'ridaynight,am
IanscheduledtogoontoSumnciscothemxtmming.
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mchp

P.S. ﬁre rating scales arrived in time.
P.P.S.

Where

is

your

miwlwn vitae?

Kathy

�</text>
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                    <text>January
pawn

A

f,

Dr. Turan

Itil

M.

Missouri Institute of Psychiatry
5WD Arsenal Street
St. Louis, Missouri 63139

16 , 1967

'

-

-1

""E§:WW:-fz

Dear

“my

Man,

.w;

I had an opportunity to speak to Don on Friday. He
indicated that the programs for the SKF material now seems
operational and it shouldbe possible to have sane data

n

analysesintheoomingweek. Hewasnotsureastothe
status of the CDI- EEG material, but did ask some questions

.

It

“

seems that
regarding the Denber EEG— behavioral study.
behavioral
ratings
is now necessary to select the specific
it
and match them with the EEG ratings so that the correlations
can be undertaken. I wonder if it' might not be mm helpful
for her to devote her time to the CDT-project. I! it possible
to assign one of the other girls to help out at this time?
..

w»

Mn.

«‘3'.

.

was

LWI-W'PT

I urged Don to discuss this with you, but perhaps he
may feel inhibited. Incidentally, I am going to California
during the last weekend @f January and can change the
ements so that I can stop in St. Louis for a few
hours either before or after the visit.

Iamsorrymwillnothaveanopporumitytoseeyou

next week.

Give

my

regards to Ellen.

Sinceme yours

”,-

Pink, M.D.
Professor of Psychiatry

Max

“'me

w'i.

‘
«7‘

Warns-y

v~limw1

a

mwmm

Mchp

�</text>
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                    <text>January 9, 1967
Dr. Tumn

M.

Itil

Missouri Institute of Psychiatry
SMOO Arsenal Street
St. Iouis, Missouri 53139
Dear Turen,

I have received the material for the clinical laboratory
paper and will have, by the time you have received this letter,
taken the material to the editor. I have also received your
kind hvitation to be nominated as a discussant of your suhnitted
paper for the CPA, and accept gladly.
'

Dr. J. Roubicek of Prague has been canmnicating with
Dr. Freedman for a number of years. In his last letter, he
indicated that he and two of his associates would be seriously

interested in coming to New York for a two year period, to
undertake and participate in a study program in schizophrenia.
The protoccl, a. copy of which is enclosed for your consideration,
is so remarkably like the program MH—ll38l, that I am stimulated

to send this to

you

for your critique.

.

are going ahead with the develOpment of a relationship
with Manhattan State Hospital and with the Department of Mental
Hygiene of the State of New York to establish a study unit for
the patients who are wansferred from the Metropolitan Hospital
Carmmity Mental Health Center to a long tem facility. This
facility will be designated as a Specific unit and bear, we hope,
close achninistrative and scientific relationships with the
Department of Psychiatry.
We

_.
.r

,
is.

V

7..

..

e
.

_.,,_.u..(:.,7_..e

—

,2”...

.

,7
V

)

“at,

w“

,'_!"if!h!‘-'1T‘-

—rn

17,-:

is.”

ran»

With this program in mind, the protocol of Dr. Roubicek
has become of specific interest for
provides a reasonable
framework for the establishment of a long range study. As I
read the notes, I believe that our study progran “Ii-11381)
is considerably more advanced than this protocol, and may
provide the basis for a collaboration between ourselves and
Dr. Roubicek within the frmmwork of a new unit.

it

Imuldbegratefulifyoumildtakethetimetoread
we can discuss them on your next
visit to New York.
these notes and perhaps,
’

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MP:kp

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                    <text>&gt;

Dr.

m

December 22, 1966
H. 11:11

Missouri Institute of Psychiatry
suoo Arsenal Street
St. 10113, Missouri 63139

Deu'mrun,

Winﬂngalleyofﬂnlabomtorytestpaper.

Would

ymandﬂihepleasegomitmmkesuchadditiomlmectiona
umybeneoeaaary.
Please as): Mike specifically to duck Table

refmnes.

II for the text

_

I mild like

200

reprints withcovers andwuld suggest that

ywozdersoomermgemewithanypmimorallofit.
Sincerely yours,
Fink, PM).
Professor of Psychiatry

Max

Mfﬂcp

�</text>
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March 27 , 1967

Dr. Ttman

M.

Itil

Missouri Institute of Psycl'datry
5&amp;00 Arsenal Street
St. Louis, Missmri 63139
Dear

Men,
Again, I must tell you how umch we enjoyed your
we accomplished quite a lot and I look forward

think

visit. I

to visiting

after the California trip.
First , I have read the TRP drug evaluation study protocol

with you

dated 3/8/67 which you asked

me

to check.

The study design

is

straightforward and I found no significant objections. Since
I am particularly interested in the rating, I paid attention
to the section on page seven. This schedule of rating is
satisfactory, with the only proviso that every effort shwld
be made to have the ward nurses rating the patients be the same
nurses for each group of patients, wherever possible. I believe
the patients will be on more than'one ward. In the same fashion
that you are asking the same physicians to rate each patient
throughout the study period, perhaps the nurses should also be
named and an effort be made to identify those who accept the
responsibility for the ratings of this study.
'

Enclosed is a retyped protocol for the very high dosage
fluphenazine study, projected for Istanbul. If this is

satisfactory, please call

I

pleased

me

and

Ilwill

send out the

original.

have read the laboratory paper again, and am just'as
now as I wassane months ago. I am not clear whether

v

�Dr.

Itil

-2-

Mardh 27, 1967

that I should send copies to each of the BCDB investigators,
orwhetheryouwould. IwmldbegladtodosoifyouandMiJceapprove.

we

agreed
My

best regards to Ellen.
Sincerely yours ,
Fink, M.D.
Professor of Psychiaty

Max

MF:kp

P.S. I have just read the booklet on psychiatric and clinical
rating scales once again. It is most useful and an
excellent idea. May I suggest that you add a specific
item identified as 1A or as number 8, in which the Turkish
nodification of the rating scales are included with a single
'

stating that the translation was made for
a specific project , but that the principles are applicable
to other collaborative study programs.

page description

Either with this addition or without it , would it be
possible to supply me with three additional copies of this
publication #2 (1967)?
Many

thanks.

�</text>
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                    <text>March 21, 1967
Dr. Thran

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
Enclosed are the three drafts of the trifluperidol paper
as of a year ago. At that time I reviewed the EEG material
available and found that neither the computer records nor the
frequency analyzer data lent themselves to analysis because
I could not discern a single pattern. It was at that time
that we examined the question of abstracting meaningful data
from the seventeen computer numbers.

I have the following computer analysis folders and
send them back to you when you wish:
Gerwitz
Sexton
Richardson

lO/27/6M

Gross

9/30/65
11/3/65

11/25/6u
3/25/65

5/7/65

Taylor

Tisdale
My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mf:kp

will

�</text>
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                    <text>March

a,

1967

.

'1». Mann. 1:11
Nissan-i Institute of Psychiatry
51400

Arsenal Street

St. Louis, Missouri

63139

Dear'mmn,
me. Dorothy and {hard Krieger am well knom, sophisticated
researchers in the field of neuro—erdoelmxology at Mt. Sinai
hospital. As old friends, they twited me to visit their laboratory.
They are particularly interested in the diurnal changes in
steroid production and rave noted that this is responsive to
dnlinergic drugs. when they described the use of atropine in
some volunteers, they complained that their Concentrations were
too low and that the effects. observed were unsatisfactory. I
told them of your development of concentrated atropine and they
would. be most grateful for a trial supply. I looked through my
file and did not bring any with me.
.

V3211;

s;

.

H,

L,

.

Vim-Iv.

Would it be possible to bring two vials of the high concentrated
atropine on your next visit to Nae York?
Incidentally, they are particularly interested in studying
psychiatric patients both with ami ‘withwt drugs and I took the
liberty of telling them of your study program in Istanbul and
Missouri. If their present trials are as successful as they
anticipate, I will enmege than to collaborate with you in the
.

at,”

"aw

m
.

v

.‘r‘&gt;i4‘7m.

IRP problem

,.

I look forward to seeing

you

on'Mday.

My

best regards.

Sincerely yours .
'

Max

Finn-1w.

Professor of Psychiatry

MF:kp

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                    <text>February 21 , 1967
Dr.

Man M. Itil

Missouri Institute of Psychiatry
SMDO Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
Here

is hilf the

supply of "Clinical

Trial of

Navane

(Thiothixene) in Schizophrenia." Would you please give some
to Dr. Ponce and Ali. I have kept some for Jovan here for
answering

reprint requests.

Sincerely yours ,
Max

Firﬂc, M.D.

Professor of Psychiatry

MF:kp

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                    <text>February 10, 1967
Dr.

Men M. Itil

Missouri Institute of Psychiatry
suoo Arsenal Street
St. Louis, Misswri 63139
Dear Turan,

I have just received the Psychiatric Research Foundation
Publication No. 1—67 - your sunmary of clinical and EG drug
evaluation studies. I think it is fine and congratulate on
an unusual presentation.
I think this is

satisfactory to send to the BCDEU
investigators as the report for this period. In addition,
would it be possible for you to send me about ten copies, in
the event that they may be useful in supporting the develop—
ment

of

new drug

Many

most

studies in

thanks and

my

New

York.

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Dr. Turan

M.

February 10 , 1967

Itil

Missouri Institute of Psychiatry
SuOO Arsenal Street
St. Louis, Missouri 33139
Dear ‘Iuran,
Some time
Hy Denber brought to my attention the
go,which
problem
of magnetic tapes
he had shipped to St. Louis, and which
hadnotbeenretm'mdtohim. Oncneofmyvisitslwent
the Computer Center with Connie and we found a number of tapes

which were then shipped

to Dr. Denber.

I thought we had shipped all except the few which I had
set aside ﬁrm the cyclazocine project.
During my last visit,
Iched&lt;edagainandallthosethatwecouldfindweresent
to
my office, except two tapes which I had intended
with
to
carry
me and which I requested Connie to mail.
Enclosed

is a

nanorandum from Dr. Denber

and he indicates
that #14 tapes are still missing. There are four
in my office
mmdtwovmichareenroutefruns . Louis toNewYork.
This
still leaves an accounting for 38 tapes.
Would you

personally institute

a
to the best solution to this question?

search and advise

Manythanks.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

me

as

�</text>
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                    <text>February 1, 1967

I». 'mmn

H.

Itil

Miami Institute of Psychiatry
5&amp;00 Arsenal Street
St. Innis, Miami 63139
,

'

Beam,
I

very

much enjoyed my

visit yestemay.

Bacloaedisﬂ'eoriginalofﬂnlistofitmintheﬂm-

belaviomlcm'analysis. IdndmditthismomingandIan
omeenndthatﬂnitmmymtb'ethemasﬂummbmin
theanalysis. Forthismason,1mmclosingaxmoopyand
Iwouldlﬂmymtoaskﬂiketopleasesitdamwithmmieand
checktm 1131: against thedata sheets that Connie umd.

Assomasitisclmckedlmﬂdbegmtefulifyoumuld

sendbackaoozmctedlistmichIeanuseforﬂnamlysis. I
domtaaemypointﬁugoingovermedatauntﬂthisisdcm.

IwillcallDr.Bamllthisaiftmommdwillbeintouch

withyouaaaoonasIMveananmr.

Sincerely yours ,
Firm, NJ).
Professcm of Psychiatry
Max

Mszp

�</text>
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                    <text>June 28, 1957
Dr. Thren M.

Itil

Missouri Institute of Psychiatry
SMOO Arsenal Street
St. Louis, Miesouri63139
.

Dear Turen,

of the anti~anxiety drug protocol relating
to domepin, and a carbon of the letter which I recently sent to
Dean Clyde. You will note that I sent the latest CDT report and
Enclosed

is a

copy

earlier memos regarding

to Dean.
Dr. Cremata called me today to state that the parenteral
form.of doxepin was not yet available and that the protocol will
be filed with the FDA excepting section three on page three and
including the first line of page u. He believes that the parenteral
fcmm will be available soon and would like a revised EEG protocol
from us. If you would like to carry out this
portion of the study,
some

item analyses

would you make up a suggested

protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

enc .

�</text>
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                    <text>June 20, 1967
Dr. Tuner:

M.

Itil

Missouri Institute of Psychiatry
51400 Arsenal Street
St. 10118, Missom‘i 63139
Dear Turan,

Enclosed are the additional data layouts requested by

Dr. Tabor and Mr. Preston of A. H. Robins during their
recent visit here. I would be grateful if you would aerxi
these on to them with your covering note.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>May

Dr.

'w

31; 1957

Tamara M. 11:11

Missouri Institute of Psychiatry
suoo Arsenal Street
St. Louis, Mssami 63139
Dear Tunan,

wart“

mweﬁ

”VH'S‘V‘VK

Enclosed

is a

copy of the preliminary data analyses which
H. Robins. AsI
Dr. Tabwwillbehemm’lhmsday, June 8, at

Isen'ttoSmithKlinemdenchaxﬂtoA.

motetoyou,

mamandlhavearmrgedtovisitﬁnithmandf‘rwchin
would be
June 11;.

wwwgmwwzflrlﬂ‘iwﬂ

Philadelphia on
and suggestions.
My

I

grateful for your

best regards.
Sincerely yours ,

no.1

Wm,

v

Pink, M.D.
Professor of Psychiauy

Max
mw~3&lt;,g.~rﬂﬂw,¢_qmay

MP:kp
'milfdl-EWJNW

2»-nz~nm;.=‘,-,.&lt;

(.A

:v-gyu-

v
r;
,;-

7,1,5;-

gov-mm—uy-rqrm.qu:

«a
or,

LWMF‘

ments

�</text>
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                    <text>August 28. 1967
Dr. Turan

M.

It11‘

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63111
Dear Turnn,
Enc1osed are two copies of the EEG paper as read at the
and as rejected by the Amenican Jouhnal 05 Pagehiazny.
These are for ycur f11es.

APA

_

I do not know if you want to send it to anyone e1se,
since the essential mater1a1 w111 appear in the book by
Laska and K11ne, but we can discuss it the next time we meet.
.

Sincere1y yours.

Fink, M.D.
Professor of Psychiatry

Max

Mszp

1:.

“1:1

mw-unmm

mam»:

‘

�</text>
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Dr. Turan

Itil

Dear Turan,

I found these: tables in

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Missouri Institute of Psychiatry
SHOO Maria]. Street
St. Donia, Missouri 53139

Look at Table 14 camfully and
has; been available since 1959

lparine in
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its

use!

one of the "him away journals.
note that Squibb fluphenazine
at Boston State and is next to

best regards.
Sincerely yours ',

,-

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Fink, NJ).
Professor of Psychiatry

Max

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rm—u“.

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‘

July 5,
Dr. Tumn

1957

M. 11:11

Missowi Institute of Psychiatry
suoo Arsenal Street
St. Innis, Mimuri 63139
Dear 'I‘uran,
Enclosed awe xerox copies of the

regarding

STP.

I

am

New

York Times

sure they will interest you.

articles

Sincerely ymms ,
Fink, 24.13.
Professor of Psychiatry

Max

�</text>
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‘October 24. 1967

Sr. Torah

H.1t11

M1ssour1 Institute of Psychiatry
5400 Arsenal Street
St. Lou1s, M1ssour1 63139
.

‘

Dear Turan,
EEG and
I have reco1ved the two reports. tr1f1uper1do1
Lthe psychotropic drugs os1ng quant1tat1ve EEG ana1ysis Both
'reports are good and I am_p1eased to have been a part1c1pant
—

You have been Verylbusy and-have created many new prints.
most of wh1ch I do not have. Boqu 11 be poss1b1e to ask Yu1men
to send me a s1ng1e pr1nt of each of the fo11ow1ng, and, perhaps
a 2 x 2 511de?
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thanks and

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«

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Max

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8aar Taran,
seconﬁ varsicn 0f the EEG~antiaﬁyrassaﬁi
ta thank yam {ﬁr
is much bgtter and i want
paper. I think
1ecat1ea of figurag»
your comments. Pieasa mate the saggestgé
fruﬁ
year collectiuﬁ
and if pessible, wauEd you saiect fiﬁures
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ﬁhat might
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yaw den‘t have and I wiil fill

Enclosed

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abarmacwlegy
SecaﬁQIy, thera is a draft of-tha c11wica1
stil? in”
is
table w1th all the.citat$an$ aﬁﬁ
payar. Tae majar
1w: ma
this
tc.se&amp;
like
campieie, but I trast you mightI‘am
revise
tn
it,
going
know what your cammants are.
I

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have

3&amp;6

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written

a greTiminary

tais shﬁuid

§est

be

tysed

draft of the haﬁlucinegen

by Kathy an ﬁcnﬁay.

‘

_

ragarﬁﬁv

Sincereiy yours»
Fink, M.m.
Professor 9 Fsycii&amp;try

Max

ﬁszg
enc .

'

_

�</text>
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                    <text>Nmnber lit ,

1967

Br. 'Ibmn M. 11:11
Missouri Institute of Psychiatry
5M0!)

metal

St. Louis,

Street

Miami

63139

Dem'mmn,

Bmlosedisadmftoopyotﬂwemportmentidepmemta

fwmfmlnmﬁxgmmﬁm. Imuldbegmtefulifym
maid review this carefully and make any necessary ametinm
mgaxdingfigumsthatmﬂdbewiate.
Inmplytoamqmstfrmm.lahmm,1ruvemmpies
ofthiedmft,euitab1ymaﬁaadmpmmdmy,mm.w1ttenbmm
for the participate at the

8mm.

Again,mybest.
Sincerely yams ,

M My ”CD.
of

£5:ch

Psychiatry

�</text>
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                    <text>December 29, l967
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39
Dear Turan,

Enclosed are a few abstracts which have been submitted.
For the Society of Biological'Fsychiatry, I took your
suggestion and have sent the fenfluramine amobarbital data.
In addition I thought they would be interested in the phantastica
classification as well.
—

it

would be
I have never been to Honolulu and thought
a good Opportunity to visit there oy attending the American
Therapeutic Society. I have asked Jovan to begin writing
up a report of the cyclozocine depression data and this should

be done within the next month. It
would like to present in Honolulu.

is this material that

I

Some time ago I was asked to look at a compound,
oxypertine, because this will be a good test of the EEG
programs. I would like to do this in volunteers, however.
it may be helpful to me if you would be willing to run a few
of your patients and perhaps to do so with pentothal activation.
Enclosed is a proposed protocol. Please review this and let
A

me

have your comments.
My

best regards.

.

‘Sincerely yours.

Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                  <elementText elementTextId="102396">
                    <text>H. «my

a.

..\

.

,,

.

.-

.

..‘_4.p_vn,‘.u.»‘—_

om- 1177.15. ,Y-.. n.

v

“Vammna...;‘_ivs-,.s—v~~x,‘.\_,

“Thumb“, ”r

V.,._1,,..,

.

.

December

air. Si lverman

York State Bureau of
270 Hedison Avenue
New York, new York
New

.

,

,.

1

»

«wuwwq

”.3, “1 "w, (Wyn-:3»

”a”! a “my--

rajhmj-J‘”

w.rp.——WW.—V1W 1'11—

l9, l967

narcotic Control

Dear Mr. Silverman:

received a letter from George M. Balk, District
Supervisor of the Bureau of Narcotics, Treasury Department,
with reference to an application for registration under the
Marijuana Tax Act. In his letter, Mr.'8elk indicates that
prior to approval of this application for registration in
Class 5. we must comply with the New York State Law concerning
research utilizing marijuana.
I have

A

copy of our

original request to the

narcotics is enclosed.

Commissioner of

indicate the steps necessary to
State Law?

would you please

with the

New

York

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Nszp

comply

�</text>
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                    <text>January 29, l968‘
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39
Dear Turan.
Dr. Karczmar has asked us to revise the 1966 ACNP
report.
In view of the fact that this paper reports our
original
descriptions of cyclazocine and of the subsequent importance

of this observation,

your participation.
I hope

I have changed

the authors to reflect

this meets with your approval. File copies are enclosed.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mex

MF:kp

enc.

"7"

‘
m
o

“r:

5:w-:-.~

331.?

w-V

Wraimwv

I

”I.”

,1,

�</text>
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                    <text>~

.A.«

.i

v

.n.

r'

-'-w--"\"

‘
-

M‘V-ﬁ/rwp'wn—W‘W'Wmm-‘vu-I—vr

January 24, l968
Dr. Turan H.

.

.uwvzns

.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan.
I have

received a

letter

from Dr. B. Lebedev of the World

Health Organization inquiring about our Turkish collaborative
study. A copy of his letter is enclosed as well as my reply.

1’!

wow

4.7K.

‘Vl'i.§&lt;

Would it be possible for you to visit with us on Friday,
February 2, to discuss a presentation before the Separtment
staff? Drs. Bucci and Simeon are presenting our observations
with depot fluphenazine and we would be pleased to have you
discuss this presentation. The meeting is held at l2:l5 pm
in the sixth floor auditorium at Metropolitan Hospital (97th

Street

var:

My

and

First

Avenue).

best regards.
Sincerely yours,
Fink, N.D.
Professor of Psychiatry

Max

MF:kp

_
A

.»

:ﬂwwm‘ﬁwtﬁ'ﬁlhr'y-s-

new-v»

a1"

‘1'

�</text>
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                    <text>January

l0. l968

Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63l39

Dear Taran.
Enclosed is the galley protf and the letters on the
fluphenazine paper. I have made all the corrections that
they have requested and would ask only that you please check
Table I. I think that “years“ under the average number of
hospitalizations is unnecessary.
I am ordering 1,000

for everybody.

If you

directly to

reprints,

which should be enough

have any additional changes. please send them
Miss Slotky with a copy to me. My best regards.

Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

Mfzkp

�</text>
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                    <text>May

8.

1968

Dr. Turan M. Itil
Tophapi Serai
Istanbul, Turkey
Dear Turan.

selfexplanatory letter from Dr. Bailey.
I called him today and he will entertain an application
from us, approximately two years. perhaps three, in the
order of $l8,000 - $25,000.
Enclosed

is

a

Please plan on your return to stop off and if you
wish. the International Association would be pleased
to make such an application.
Alain Sanseigne called to say that
available for the Istanbul study.

no funds were

are still working to hard and trust that you are
enjoying yourself. My best regards.
we

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>July l0. l968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan.
I have read the enclosed preprint by Lubin 3; gL.and
written the enclosed letter to him. I had seen this
report in Washington and encouraged him to send it to me
since he seemed to minimize the possible applications of the
period analytic approach.

have

you can send him (or me. if you wish) some of the
you made up of the relation of the visual and computer

If

tables

scoring of sleep records, the data may help to modify his
present lukewarm View of the period analytic method.

I have offered to analyze some of their tapes.
especially if they are willing to report the data of comparable
analytic methods to the APSS since I am confident that the
programs will match up favorably, and I am sure that they
can afford to pay reasonable consultation fees since they

are paying such

new

to Astropower.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>August 30, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

that we have not sent you samples of the
data
output. I was waiting for xerox copies of the
laboratory
but
these will not be available for a few more days.
full set,
In the meantime, enclosed are sample sets from one of our analyses.
Don

reminded me

The laboratory standards are our standards and your reports
will, of course. have a similar set with your standards listed.
Where
states New York Medical College, we will list MIP.

it

Each individual sheet is a single report from a single optical
scan sheet. The age, sex, date. drug and dosage were keypunched
separately from lists supplied by my staff. In the new forms
this data will come directly from the form. The third type of
output is a listing of all the tests for each patient and this
is derived directly from the individual sheets (you will note
that these do not have drug or dosage listed for each date and
this will be corrected in the new forms).

are able to handle the MIP-PLD forms and provide you
with these outputs. To do so would require the forms and a
clear statement on the head of each form of the mate. drug,
dosage, age and sex of the subjects.
We

can provide outputs for your present forms
be able for the new forms within two months.
We

now

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

and should

�</text>
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                    <text>August 22, 1968
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

I very much enjoyed my visit and have completed some
of the things on my agenda. Grass Instrument will ship two
amplifiers and they should arrive early next week.
Dr. Barry is coming to visit on Friday, August 231 He
does not need a protocol but suggests that we take care of the
full filing with the FDA ourselves. As soon as I have an IND
number, he will ship the supplies of fluphenazine.

I have already dictated a letter to Sidney Merlin
for Fellowship in the ACNP.

recommending you

Enclosed are the bills for some of the computer time at
the College. The lab scale ~ psychopharmacology bills represent
one—half the costs to date. It would be most helpful if payment
for these charges can be made to "Division of Biomedical
Information Processing ~ New York Medical College“ and sent
to Dr. Donald Shapiro at 5 East 102nd Street, New York. New York 10029.

I
My

am

also enclosing a statement for

my

visit that is appropriate.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>August 7. 1968
Dr. Turan H.

Itii

Missouri Institute of Psychiatry
5400 Arsenai Street
St. Louis, Missouri 63139
Dear Turan,

Enciosed is a draft of the paper by Drs. Schwartz and Feidstein.
the tapes have been analyzed but these were not completed
before Dr. Schwartz went on vacation. I expect him to return
in September, since he is in Engiand. At that time I hope he
will go over the material and rewrite this report inciuding
an outline of the next important steps.
A11

My

best regards.
Sincerely yours,
Max

Fink.

M.D.

Professor of Psychiatry

MF:kp

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                    <text>August 6. l968
Dr. Turen M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Turan,

Separately

I am sending you

five capies of the report

”Cyclezocine Classified as an Antidepressant by EEG
Criteria and its Clinical Trial". Following our discussions,
I am sending it to Dr. Bracelend for his consideration for the

Amentcan Jounnat 06 Psychiatny.

I am

believe that this report should have

not optimistic, but
exposure.

a wide

I am also enclosing a few copies of the companion report
reflecting the work in New York. I have asked Dr. Braceland

to consider both reports together.

Finally, I am enclosing a new review on EEG and drugs
which I have prepared for the Annuaz Review'oﬁ Phanmacology.
I trust
does Justice to your work.

it

I look forward

to seeing you on August 16.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>August

l,

l968

Dr. Turan H. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63l39
Dear Turan,
have modified the laboratory data form to siit some
needs
of this laboratory. We are awaiting a new proof
of the
but I am enclosing a xerox copy of the latest draft available
we

to

me.

This will indicate some of the changes which we have
considered advisable after using the HIP form for the past
few months. These include color divisions between items;

exact values above the place to be marked; the addition of
items for standards. laboratory and route, which we believe

will

be

useful.

on a second form for medical examination
believing that a single sheet on a single side is the best for
and purpose. The laboratory form will be completed by a
We

are working

laboratory technician. We are working on another form to be
completed by a physician and/or technical research person and
this will include such items as weight, blood pressure and skin
and eye changes.
As

soon as a provisional copy

My

best regards.

to you.

is available

I

will send'k

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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                    <text>we, ,7

—;

w‘ (

winery-en

.nﬁ-r»

..

av.v--v.~-w»—.r .. --

*-.-\

..:,-,

w—r

y,

v77". 7-9—7 '

'rw'wvv

December 3, 1968
Dear Turan and

Ali,

Enclosed are draft copies of the summary report
of the fluphenazine experiences, as sent to Dr. Rothman for his

book, "Changing Patterns in Psychiatric Care".

While I anticipate
comments, you may assume that it will be published
as submitted. As soon as I know the publisher, I will let you know.
some

editorial

My

best regards.
Sincerely yours,
Max

mil

Fink,

31.1).

�</text>
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                    <text>.-

,

January 10, 1969
Dr. Turnn

Itil

University of Misoouri School of Medicine
St. Louis, Missouri
Dear Turan.

Enclosed is part a! the consultation feet for your
participatinn in our program, ’EEG and Euman Psychopharmncology"
during the past few months, on your visits to our laboratories.

toes ($300) have bean requested and will be forwarded

The tamaining

promptly as received.
Many

thanks for your cantinucd

in this program.

1”,

my

1
a_—-.-

interest

and

asaistanca

best rcgards.

&lt;

“ﬂy-lava:

Sincerely yours,

«4.

-p-,

JwﬁWv-ﬂr.

Err-«(y

Max

m».;wx;n

ﬁ‘zv"w€'

mf/

Fink.

M.D.

�</text>
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                    <text>April 21,
Dr. Torso

1969

Itil

Profoaaor of Psychiatry
Missouri Inatltute of Psychiatry
St. Louis, Missouri

Ref:

CP~

l&amp;,368

Dear Torso,

For some time I havo expressed tho desire to examlno
potential psychoactive compound in the EEG analytic scroen,
without tho utual animal or clinical olues, which could influence
our EEG evaluations. Dre. Betas: and Pitts of Pfizat Medical Research
Laboratorlen havo mods such a otudy possible. and I am writing to ask
your assistance.
-

a naval

‘

Enclosed is a cepy of tho available animal and clinical
pharmacology data, an augplitd by Dr. Berger. 1 would be grateful
for your reviuw of this notorial and your toaponse to the following
question:, which I propose to use in formulating a daftnitlvo pilot
A: I would like to start with singlc, oral dosagao in young
study.
(21»35 yearn) male voluntoero, the questions aro:

what dosage should be tasted
what incromonts should be tested ?

initially

?

If

no

effect,

‘rr'r‘n

~

tear.

a

egfocts

7

At what time
What

~svr¢x,ys;rﬂf”vrt=v'm,~

-'

é

in the

reviaw of the data

intorvala can
maximum dose

7

-'

.

*

r-‘u.~"

«damp

a;
~19

anticipato clinical and/or

that should

EEG

be toatod beforc your

effects should ho tested for most carefully 7
secondary effects are experienced, what are the prohibited

what secondary

Aneuming some

antagonists? the preferrod,

”

wt

What

if

are the primary

known ?
EEG

leads to be examined?

Any behaviorol questions that may be anticipated in addition
the
one: included in the Clyde Mood Scale, which we have used in
to
these studies to date ?

�'-

x

{A

1:11

0

I

I

a

o

I

o

0

2

a

I

O

.

.

.

.

.

April 21,

I would like to begin these studieq about June 1, and would
appreciate the opportunity to discuss this with you beforo the APA

meetings in May.
Many

thanks, and

“\i.
"\x

my

best regards.

\.

\‘i
5

u

‘\

\\

Sinceréﬁy yours,

Max

Fink, M.D.

1969

�</text>
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                    <text>March 31. 1969
Dr. Tatum E. 1:11
5600 Araanal Street

It.

Lapin, Missouri

Bear Turtn,
Some weeks ago, w1111a3.2uag was in New York and
I issued 13:: year fer him to visit and review
an
invitation
accepted
our computer analytic programs at the alaepvxﬁs. He did so, by checking
the playback at one of ab: records we had analyzed using the pregram
from St. Louis. modified for the IBM 1800 and with the Klinganbarg

revised standards.

‘

His summary is submitted as three figures and
copien of which at: unclosed.
Agreement

in stages a,

a matknd discrepancy in stage:

C

A, and

and E.

D

tablet.

1. good; but there is

Please review those figures and on your next trip East,
can go over tho original data as Bill lung did and assess
perhaps
the bases for the differences in the classifications.
we

Hy

best regards.
sincoraly yours,
Max

cc: Bill lung

Fink, M.D.

�</text>
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                    <text>August 25. 1969

Dr. Turin E. 1:11

Missouri Institute of Eoychdntry
5400 Axlonal Street
St. Louis, ”issuer:

Boar

63139

futon.

Ht have cooplotod our phaao I study of pyrovalorono.
rho conclusions arc summarizod 1n the enclosed report, aunt
to Dr. Boyer. the EEG macorlnl shows pyrovalorone to havo a

,.

,

wwgyxwu

umwvw—z—e—w—av

pattern similar to tho anphotaninos. but
deflnlttvo study.

must depend on a

its classification

An wo had discuased in Hiaml. I am oloo sanding a copy
to curl Pfeiffar. If a collaborative clnnaiilcation study
wore dons wn would rooiunond clnslo 160 as dosages. and
other conditions, as describod on page 5.
‘

—

Hy

but: regoxda.
Sincerely yours.

-mwn

x
-

HI!

’1“.

”OD.

Profoaaor of Psychiatry

Misty

cc: Dr. Boyer

�</text>
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                    <text>Dr.

W

July 30,
M.

1969

Itil

Missmzi Institute of Psydxiatry
5M0!)

Arsmal Street

Dear

Tum,

St. Lads, Hissmﬁi

63139

kind of you to invite me to visit 31:. Innis,
to the residents.
partiwlarly to present some of our workmmmal
of convulsive
I have recently canpleted the meloaed
send enmgh
am
can
I
of
surewe
is
interest,
marapy. If it
residents.
for
copies
yam

It was

Is
Hy

Wt

10—11

a

good time

for you?

best regards.
Sincerely yams ,
Fink, M.D.
Professor of Psydﬁatry

Max

Ml’:kp

�</text>
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‘wu—m .-V,.__.,—,_,

October 13, 1969

ﬂr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turen,

Please excuse

my

belated acknowledgement of the special
me - in the invitation to join the
to the meetings and to an active

honor which you accorded
T.C.N.P. I look forward

participation.
is

Your invitation to attend the initial meetings in August
welcome, and I plan to join you in a formal presentation of

our neurophysiological studies. I have mentioned
Hy Denber and he has accepted our suggestion.
I have

that the
My

just received 8.1etter

CINP

has changed

its

this to

from Heinz Lehmann

best regards.
Sincerely yours,

Professor of Psychiatry
Mszp

indicating

meeting date to August 11-15, 1970.

�</text>
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                    <text>October 6, 1969
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
The enclosod

version of "§7Cycloserino Therapy of Psychosis

by Symptom Provocation” was sent to Fritz Froyhan for publication.
lo accepted most of your suggestions - and would be delighted
to see a more detailed EEG blood level analysis. Jovan will send
you the available data.
I have also sent a copy

to Ivan Bennett.
Sincerely yours,
2"an

Fink ,

M. D I

Professor of Psychiatry

an: :kp

�</text>
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                    <text>J.ls-

.
«w:

1:»

r.Am-

’20-“

av

December 22, 1969
Dr. Thran

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

Enclosed

paper, part 1.

is a

copy of the

galley for our cycloserino

I have ordered 400 reprints, to give you 200 for your
use.
you wish more, please advise me and I will change

if

,;

the quantity.

'31»?

—\

My

best wishes for a successful

1970.

-,-w"-mya;7:&gt;

Sincerely yours,

v

-—

=

-.
V
&lt;-

'-

Fink, M.0.
Professor of Psyhhiatry

Max
agmrtwvrwnzzvrr-lvxw't7r."

Mszp
"'1

:}Q,§m'tm&gt;.-J«A¥a,wc;‘qn

-

1

‘

{VF-'3‘...

»

~'

m

«HM

'1'

~a1~qmm3¢mmvw

�</text>
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                    <text>Hatch 10, 1970
Dr. Turan

M.

1:11

Missouri Institute of Psychiatry
5400 Arnonal

Street

St. Louis, Missouri 63139

Dear Turan,

have never receivad reprints of the trifluperidol
paper. These are the only two requests I have received.
Would you care to answer these and perhaps send us a few?
Wu

Also,

this is the only sleep classification reprint

raquoat.thnt I have not answered.

Sincerely yours,
Max

Yink, M.D.

Professor of Psychiatry

Hszp

7A.“.

A};

A

‘

‘

‘\

‘

‘

'

�</text>
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                    <text>March

4.

1970

Br. Turan M. Itii
Missouri Institute of Psychiatry
5400 Arsenal Street

St. Louis, ﬁissouri

63139

Dear Turan,

Separately I am tending you fifty reprints each of the
cycioserine and oyciazocine papers - just to prove that I
am

still

working for you.

There are an additional

whose address I do not have.
My

set of reprints for

Dr. Ponce.

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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April 24,
ﬁr. Turan M. 1:11
Missouri Institute of Psychiatry
5400 Arsanal Street
St. Louis, Missouri 63139
Dear Turan,
I have been checking my

v—qu

,rv-W

..
v-

viva“

.mwu-

5-

r
raw-aw“

mmmcr-m

1970

data
for your files.

sheets from your study.

data books, and found the enclosed
Don suggested I sand these to you

Sincerely yours,
Fink, $.ﬂ.
Professor 0f Psychiatry

Max

MF:kp
BBC.

�</text>
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                    <text>:

V."‘»V~'.'qV:"»-W --

»~.v&gt;~&lt;cr~-

April

0r.

Turan

M.

-

2|,

m

.wm

WW""’-

»

'~.l"av'lum~.1.n—:,

.7. .7

wﬂwﬁﬂgxw.’ v.

I970

lfil

Missouri Insfifufa of Psychlafry
5400 Arsenal Sfreef
8?. Louis, Mlssour! 63l39
Dear Turan,

Separately am sanding you fwo boxes which confain
reprlnfs and papers fhaf yau requesfed some Time ago.
I

I

*rusf

seeing you
My

you had a happy

In San

Francisco.

vacaflon and

I

look forward

best regards.
Sincerely yours,
Max

Fink,

MOD.

Professor of Psychlafry

MF:kp

V

A

WW7)!"

to

_-‘,.

7.

“Mp."

-1,

v‘

._

a...“

u“. 7,.

V

�</text>
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                    <text>July 23, 1970
Dear Turan,

Skiing in January

?

Richard Roch of Dartmouth called to invite a program
group in Aspen for 1971. I suggested that
would
be
pleased to present your findings on the EEG effects of
you
psychoactive drugs on the sleep EEG. The focus is on the correlations
of EEG in man and animals. He is inviting Wallace Winters and himself.

for the Brain Research

923WL

‘57

.

Vim"

I suggested that Charlie Shagaas present data bridging man and animals;
I would do the awake EEG and would you take the sleep EEG ?

"5‘51“:

m7

The focus could be the

effects of indole
The

4ms=rmw

and

hallucinogens, particularly the

anticholinergics.

date: January 18, 1971

Meeting dates: January 16-22, 1971

r-v-

'v

Place: Wildwood-at-Aspen

(I will

be taking one or two of

my

See you in Prague and
My

children. ﬁring

Kurt and

Istanbul.

best.
—Sincerely yours,

Max

Ellen.)

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                    <text>r -W-

_

w-‘-"

Ann-x

n‘wmmww-nw—rw‘

u

.—

mm

, .m

“Mm...”—
,

,

.

~v——-‘

“V

“W

..

r-"I

warm-Vane!

September 28, 1970
vm‘v‘vmmw

Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139

-

Dear Turan.

Enclosed

and the forms

is a copy of the letter from Dick
for the conference registration.

Would you
My

scrape up an abstract and send

it

Roch;

to

best to Ellen.
Sincerely yours.

‘

r:
_‘

"w

Pink, M.D.
Professor of Psychiatry

Max

"ﬁr

-.~«

”3“"

mwo,ﬂ.,r‘

riwwtpwunr&lt;njuxw

v»

rwv—w.

I'm

3

7'4

‘

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:um-a

wer-qrm“‘

W

v.“

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011C .

my

answer;

him (or no)?

�</text>
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                    <text>September 3, 1970
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Deer Turen,
You organized and ran a most interesting and stimulating meeting.
Most important, I admired your keeping your ”cool” despite Iany extre-

ordinary pressures, including the cholera scare: Congratulations!
Al has told me that the Friday session was most successful and I
I
specielly regret massing that. My trip to Athens was necessary, forhas
found that the estimated costs for this study (like so many others)
doubled in a year and I must negotiate once again with Washington.
I know you have had extraordinary expenses in your meeting.
Enclosed is a contribution in support of your meeting, which will in
a small way indicate my enthusiasm for your efforts.
My

best ﬁersonel regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

mf

�</text>
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E

E

E

'»&gt;n9-n'-n

~,—

-

417'?“

__

m'v‘wrsw

Wmm‘ﬂrx -v~:--wv-v-~4x

v-v -

'«s-asapr- ww-nw 'r‘I'V’Y"WF6‘~V;r\Tvr"IIr-w!,~‘K'¢"V'.w.\V‘-.~p'll

November

,

”mu

4,

'4

l-n’xr‘n‘ w-muv .—».

~.

.“ m _.,,._..

~

gnaw

1970

Dr. Turan M. 1:11
Missouri Institute of Psychiatry

Street
St. Louis, Missouri

5400 Arsenal

63139

Dear Turan,

Please read the attached notes from Dr. Sonowski
call me next Thursday or Friday. I will be out of town
until Thursday afternoon.
and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkt
em: 0

,» -

nv

u.‘

,

..

..

,.....~‘y- u—

w‘

�</text>
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                    <text>lovember 2, 1970
Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
we

have analyzed and re-analyzed the data for

this

are now satisfied that it is presentable.
Don and I would appreciate your comments. I would like
to send it to the Mohivu 05 Gum Pagdbémy, and
if you agree, I will add the citations and promptly send
study, and

it

we

out.

Sorry for the three year delay.

Peale.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt
Enc.

Amob—Fen—DA

Study

�</text>
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                    <text>March 1, 1971
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

It will be a privilege to participate in the 1971-72
of research seminars at the MIP, and have set aside February series
25, 1972
for this pregram. ECT is an exciting part of our research program
and we should have new data by

Thank yen for the
and co-workers at MIP.

that time.

invitation;

my

best regards to

my

friends

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>W___

_

~...m~

_

V

‘

‘ _,_

._._.

.

,..,_

,v,

4“,.

,.

,.

,_

,

,

,

.

1,.

“my“ unmanum.

\»-.w.4r~v..-q..yaw,»-New.

.;-

-

,

.

“mi/'lv-Ialr

“any".

war-

3-

vulrgn-vvvlrnuu”

July 22,
Wan'mrvnnrawwr

_

1971

Dear Turan,

I find the report for the Transcultural Symposium very
discussion, I would make two suggestions.

good. In the

data,

Prien

&amp;

Cole, in summarizing the high dose chlorpromazine
suggestions that dosage is a factor in the

make some

treatment of certain scizophrenics, particularly in relation to
age. I believe it would be helpful if their views were referred
to in the discussion.
w

JHW‘”

W!"

”"5""?

W’WW—

'

in"""!""1‘1’7~'"‘7i

‘27

W‘W5W-W7kfd

4r;—

WWWWWWTWWSEFW

During the past few years, there has been some discussion
about 'enzyme inductiog' as an aspect of the metabolism of
drugs which may affect the efficacy of drugs in some patients.
Prior experience with drugs permits the tissues to learn how
to metabolize or how to adapt to high tissue levels of the
most toxic agents. A good example is the development of tolerance

to opiate and hallucinogenic drugs. This, too, may be a useful
aspect of the discussion, particularly since it provides an
alternate explanation to the genetic hypothesis.

I have just returned from Athens, where I found the
study progressing very well. The initial case~finding phase
should be completed by the end of the summer, and I hope
to spend a few weeks in the actual examinations after the
WUrzburg meetings.
I trust you will enjoy the second half of your sabbatical,
and should you have the occasion to step in New York en route,
my home is open and your welcome is always assured. My best to
Ellen.

WWW"?

5;

Sincerely yours,

0'.

mm

"are

:
WWWM

Max

Fink, M.D.

�</text>
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                    <text>chober 30, l97l
Dear Turan,
The enclosed leffer senf me lo my basembnl flles, and
have pulled dupllcafe coples of every reporf durlng +he
halcyon days of MlP's collaboraflon-- and I am sendlng these
10 you separafely. I fall, however, To flnd fhe repor+ requested
ln fhe enclosed lefler, whlch ls who? sent me to my flles ln The
flrsf place. And, lhe EEG manual by Shaplro -- l have one lasf, flle
copy. Perhaps Thls Issue should be redone and republished.
l

By now you
My

besl

To

could be back. Trusf

all ls well.

Ellen.
Slncerely yours,

�</text>
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                    <text>o-unr

WWrr-—w-—..._r,ww

~w-—mmm..wm, “WW
.

.

w

.

m.

.»-...r.

m.._..__...‘.

._

.s.7

..._,......;......___.7. “V.

.

.

.__... H.._~,~.w. ..

w,

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.

.

a

November 8, l97l

Dear Turan,
IT was a pleasure To have you visiT.
ACNP
The
enjoyed
meeTlng, and voTed our friends in.

I

hope you

am enclosing a xerox of The page proofs of The
fenfluramine arTicle. have found 2 errors (noTed). if you find
any oThers, elTher wriTe me of To Springer Verlag, Heidelberg,
i

l

Germany.

Mr. Pavel has checked The cosT of The parTs for The
in
small
boxes-quanTiTies, $34. Should you wish him To build
These, he can do so. I would suggesT $75 each, paid To him.

How

many ?

Andy Don

clinical populaTion,

arrived This afTernoon, and

had

i

a good

could underTake some of The sTudies we discussed.
i will
Try To esTablish him aT The VA, and should he succeed, we
could do parallel sTudles, should The markeT call for such work.
i

Send us your Tapes-- as l suggesfed, iT would be
To
have a l0 minuTe run of an oscillatory signal
helpful
so ThaT we could check The sysTem before you record a loT of daTa.

mosT

My

besT To Ellen and The

children.
As

ever,

.w

�</text>
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                    <text>December 28, 1971

Dr. Turan

Itil

Missouri Institute of Psychiatry
5&amp;00

Arsenal Street

3t. Louis, Missouri

63139

Dear Turan:

received the tape from Istanbul, and found it comWe analyzed your “records” and
the range of values looks much like-tho EEG playback.
We

patible with our tape system.

Our difficulty is in identifying the “record” on the
tape. For example, our firtt EEG on playback looks like netthcr
of the two playbacks you sent. We have more ZO-aecond epochs
than your sample; the artifacts do not match, etc.
We

make

if

will

be pleased to analyze

available paper or card outputs, or

the data are complete.

similar tapes,
some

and can

statistical analyses

I an enclosing a summary outline of instruments we
used in another atuiy. This will give you one way of identifying
tho racord on tape, so no can find the correct record for each
subject.

My

beat for 1972.
Sinccrcly yours,
ﬂax Pink, H.D.

Professor of Psychiatry
33:13
But.

�</text>
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                    <text>February 8, 1972

Dr. Turan M. 1:11

Professor a Asaociate Chairman
Chief, Section of Clinical Neurophysiology
&amp;

Psychopharmacology

University of Missouri
5400 Arsenal Street

St. Louie, Miaaouri

—

Columbia

63139

Dear Turan:

Congratulations. on your energy and enthusiasm to edit a
and drugs. It would be a pleasure to participate, and
I will try to provide the two articlea you requested.

book on

CNS

our

new

EEG

"EEG Profiles to Identify New Psychoactive Drugs and Measure
Bioavailability" by Fink and Shapiro will privide a aunnary of

classification scheme, and our recent 4 years of experience
drugs and conpariaona of drugs of different fornulationa.

will

I will be glad to work with Volavka to prepare a summary
Effects of Druga of Dependence and Abuse". describing the
similarities and differences among alcohol, opiates, amphetamines
and LSD, etc.

on

“CNS

In your

list

of proposed models. I aieaed a presentation

by Don, and note the tapic XII ~ Statistical Techniques. while I
aeaune you will ask Mucciardi, perhaps you would reconsider. Muc~
ciardi'e experience in limited and his recent report to you primitive.
Don and his aaaociate Marvin Glaaaer have examined acne of our data
by many etatiaticel techniques. Our data is extensive and an invi~
tation will provide an incentive for then to present their experience.

�away—w

mnw~

u

-

Dr. Turan

I

M.

Finally,

do not know

Fun,

fun.

Itil
who

.

February 8, 1972

aro Caillo, Danbcrg, Horowitz, and Robinson?

thoir work. Should I?

tho 3 F's, I havo addad a fourth - Flying; nnd Family,
Financial arc vary unaful guidelines. The chapter: will be
To

My

later this

but to Ellan,
month.

and

I look forward to using your family
Sincerely yours,
ﬂax Fink. M.D.

Profasaor of Psychiatry

�</text>
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                    <text>November

28th, 1972

Turan Itil, M.D.,
Missouri Institute of Psychiatry,
5&amp;00

Arsenal Street,

St. Louis, Missouri

63139.

Dear Turan,

Enclosed

is

my

contribution to your volume of
EEG. I trust it meets

Pbyahotropic Drugs and the Human
your critique and is acceptable.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

arm/1.1

Enc.

�</text>
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                    <text>731-026E

January 15, 1973
Turan

Itil,

Missouri

M.D.

Institute of Psychiatry

shoe Arsenal Street
St. Louis, Missouri

63139

Dear Turen,
We

very much enjoyed your

visit to

our laboratories

these past few days, and wish to thank you for all your assistance in
the critiqic of our ongoing drug research program. Both Don Shapiro
and I appreciate your taking the time from your busy schedule to
review our ongoing research in new drugs and cannabis.

I shall be leaving for
my return.

or write to you on
Again,

my

Amsterdam tomorrow, and

will call

thanka.
Sincerely yours,

Max

Fink,

M.D.

Executive Director

mf/

�</text>
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ruwvmusuv

K"

731-632

April 19. 1973
James mama. Pam...
Professor at Pmkxmiolm,
University of California,

Irvine, California.

Dear Jim.
0:: first. Mm'of the nun-y. I gent 115 on
to the publish”. In ”wt-caning 1% today. I Milled
in a. fur unassisted emits” in style, reﬂecting
and. an: willingthe format of the othcr mo
Archives
send
on
these
to
the
simltsmous
to
for
mu
.

Win,

publicatian. Please consider than suggastiona, and
let me knew if they are acceptabla.
)5 thanks.

81:3:me your: ,
1h! Pink,
luv/1.1

he.

an. T.

A.

V1111!“

H.134.

�</text>
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..

~-—~-

A.” &gt;vﬁq~~

"‘

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v“ ~...
«

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-

—,_»

v

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,

1am wempg—“www.mqr
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crew.“

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__.~.:_l£iu_igi~_,_‘l~

731: 09hI
-.L__—._

April 18, 1973
M.D.
Itil,
Missouri Institute

Turan

shoe Arsenal Street
St. Louis, Missouri

_—.h==&amp;:$h

of Psychiatry
63139

._.;‘._i.h“\l;-_e_._‘_‘___..___ge

Dear Turan,
The Association would be pleased to accept grants-in-aid
on behalf of your studies, and will process the requests for
expenditures according to the instruction: accompanying the
awards. In our negotiations on behalf of others, with for
example, the National Institute of Mental Health. we have received
an overhead allowance of 2&amp;5. In other instances, we have
negotiated a flat figure of lesser amounts, and we would be
able to establish an overhead rate for each study.

enclosing sample copies or the forms used by the
Association in its bookkeeping operations.

I

am

to using the conditions of the
director in approving the
executive
award as a guideline to the
Board
may. at its discretion and
expenditure requests; but, the
your request, consider modifications consistent with the intent of
the award.
We

have been accustomed

I trust these notes are helpful,

earnest cooperation.

and

I can assure

Sincerely yours,
6,
‘

Max

II

V;

Fink,

M.D.

Executive Director

you

of our

'

\

~&lt;.i_.a..-.._~

�</text>
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June 21st, 1973

I. Boyd.
Aecoxmting Department,

be; June:

Gnu Imtrmnt

WW.
Bur

W30

Cm,

021690

Mr. Boyd,

I received your letter of Jun: 8th. “around
to no at w femur institmsion. New York Medical 0011930.
Payment will be ad: sufollm:
Invoice l38001w, $68.55. in! 33er received on
5/29/73. and payment will be made by the ﬂew York
Medical Confess by June 30th.
'

Balmce of 1min: for shipping EEG paper. 8181;.35.
Ind not requested payment for thin. as I had not
received a. statement. I have requested for a. check to be
inn-d by the New York
Collage. md this should be
vithin tho nut pay period ending July 31“.
ant to

we

m

313%.

mm.

If eitbar 0: than accounts: are not paid by Jun
plane call or write to an gt my new addrou above.
Bimoroly your: ,

rink. 3.13.
m
l’rofouor of Ply-chum
luv/1.1

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                    <text>73AP-73kAP

1

.
1-!

—

,w

a“...

1)!

or. sound 17. Klein
Hillnida ﬁospital

Glen Odks.

'1
I‘
A
W?

How

October 1973

‘

York 11304

’

Boar Deni

"'rr

‘Wyl’I-G'ﬂo‘zb‘v‘ﬂg

”‘1!“"510"

(”WM

Wm

I an pleasod to confirm my participation at tho APPA meeting
bath on a disco-aunt of tho Friday panol and no a nonber of the
3:33:11 panal team.
I want once again to congratulate

program.
my

you on formulating a

best regards,

‘

~

Sinoarely yours,
Ha: Fink. K.D.
Professor of Psychiatry
‘Mrlcis

fine

�</text>
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                    <text>mww

!v

r
0'

-.

rm: vvwr 'r :vw

V.»

mm vwcu

&gt;‘err'wer-vv'" -»u—» uw‘mruv-‘uﬁ .. .v.»......m&lt;.vv.—.»v~.~wvww». -....v.

-,

-—-r..r

7.”-.- ..

. ,7

. vp—vn. ‘

—

f"r~'uu:v."r\’l&gt;

-

,.. vmv 1...“,7-“, ,r ,. 7.7.. rm

Turm Itil, Me
321 Research

150 White Plains Road
Terrytown, new York 1059,
Deer Turen,
Our work in bioeveilebility is described in the enclosed
reports, from 1971, lQTh end our latest. "Relation of EEG to Blood
Levels of Peychoective Drugs". The lest will be yubliehed by Merlin

and Gottechnlk.
_

you

in

A

report to the

two weeke.

APA

is being completed

end

will be sent to

a"

The chapter from Gordon

”mm.

m2.-

is

my

only other recent report.
but it essentially

It also cites the bioeveilebility studies,

replicates the report in your book.
My

wqmwmmrmi

best.
Sincerely yours,

wwwummmanc

wee-“m

5w

[~‘§q?'-W“Jw'l

,‘x'h

«a

Wm

"mural-R"

Fink, M. D.
Professor of Psychiatry

Mex

-

:-

.c.-,,..\,,.... . .

Do

W:

Lin-W

‘

March 2h, 1975

w

'

w-

MF:ed

Enclosure

�</text>
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                    <text>‘3."

October 31 , 1975

Itil,

Turem M.
HZI Research

150 White

Tarrytown,

M. D.

Plains
N. Y.

Road

10591

Dear Turan,
Would you kindln-eend a copy of your report on the
rating scale for TV records in psychophamcological research.
to the chairman of this department, Dr. Stanley F. Yolles. He
is particularly interested in using TV for monitoring sleep,
psychotherapy, and sex therapy. When I described your work to

him, he was unacquainted with

If you have
Many

an

it.

extra, send

me

a reprint also.

thanks.
Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max
I:'

m-

.-

.r

v—p—wwn

«-

:c»

.q'

MF/mr

�</text>
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                    <text>Turan Itil, M.D.
HZI Research
150 White

Tarrytown,

Plains
New

Road
York 10671

~

Dear Turan,

It

was a pleasure to visit your laboratory on Thursday.
The development of a neuropsychologicai test battery which can be

easily applied, and easily scored, in an important contribution to
diagnosis and I look forward to the developments in your laboratory.

I were heavily involved in
psychiatric probleﬁs for computer resolution, we
organized a diagnosis system based on the interaction between the
psychiatrist and a computer terminal. Our aim was to ask the salient
questions, and based on the psychiatrist's response, provide him
with a statistical statement as to the most likely diagnosis for
the subject and the confidence with which the statement could be
Some

when Donald and

years ago,

programming various

viewed.

Two

programs were completed and

included in the report enclosed.

I hope that
My

it

is of

some

their program listing is

help.

best regards.
Sincerely yours,
ﬂex Fink, M.D.

grotessor of Psychiatry

�</text>
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                    <text>March 29, 1979

Turan Itil, M.D.
Research

HZI

Tarrytown,

New York

Dear Turan,

I have had a chance to read the Final Report
Task Force on
with some
attention to the details, and Bioavailability
I am writing because I believe
the report is less sanguine than need be with regard to the
methods already available to us to assess bioavailability
and pharmacodynamics of drugs. Specifically, the section
7.2.2 should be expanded in some way to reflect the state of
knowledge presented at our sessions. You may recall that two
methods were discussed at length as
the changes in
brain function induced by drugs whichreflecting
crossed the brood-brain bustier
barrier, that of pupillography and of quantitative electroencephalography. These methods provide valid end~points to
the effects of drugs on the brain, and
as quantitative as
established biochemical methods in this are
regard.

of the

by

ACNPwFDA

Would you consider amending the paragraph 7.2.2
the addition of the following:
". . . There is currently no recognized standard

approach, although pharmacodynamic methods such as the
quantitative EEG and pupillography, which are responsive to
the effects of drugs which cross the blood-brain barrier,
provide the most logical opportunity for such development."
Quantitative EEG methods provide indices
the assessment
of benzodiazepines (diazepam, bromazepam),formianserin,
doxephn,

thiothixene, phenytoin, among others, in studies from my
laboratory alone. Others have made similar contributions, and
the negative statement of 7.2.2 ought to reflect this experience.
My best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�Y'"

m...

wwwknm

April
Turan
HZI

Itil,

Research

150 White

Tarrytown,

-

10 , 1978

M.D.

l

Plains

Rdd

New York

Dear Turan,

It

nice seeing you again, and we did enjoy the
visit with Ellen. I felt a bit better after the debacle in
Ottawa since we did have the occasion to talk again.
was

I enclose the reprints from the recent work by
Bolwig. It is the clearest data that ECT produces an increase
in permeability of the blood—brain barrier, and is quite compelling.
Maybe it could be used in the TR? problem.
My

best regards.
Sincerely yours,

Max

Fink,

M.D.

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                    <text>May 25, 1983

Turan M. itil, M.D.
HZI Research
150

White Plains Road

Tarrytown, New York 10591
Dear Turan,
l have been puzzled by the evidence for the nobtropic class of
psychoactive substances. Using pharmaco-EEG methods, I studied a number of the
peptides for which a nobtropic status has been claimed. I was unable to elicit either
an EEG profile or evidence of behavioral effects. I have also read the literature,
and found the published data until 1981 thin and unpromising.

Lately, you have published an editorial supporting such a classification -but the editorial lacked the evidence for the claim.
I recently came across the citation list for the special issue of Drug
Development Research (2 (5), 1982) which has a number of titles which suggest
that they might contain the evidence for such a classification. 1 requested a copy.
of the journal from our library, and we have no subscription; I requested an
interlibrary loan, but as an unbound journal, it is not available. Hence this letter.

Do you have a copy of the issue ? Would you lend
Many thanks.

it to me for a few days

?

We began our first patient on Sertraline on Monday of this week. (We
actually began two, but when I checked the inclusion criteria, one patient was 70
years of age, and Dr. Gholly rejected her.) I also sent a protocol for an EEG study
for BHT 933 (azepexole) to Penny, and hope to examine it this Fall.
I trust Ellen and the children are well. We expect Jon next week, and
Rachel said that she may fly up to visit with her brother as well. I cannot get to
the NCDEU meetings this year, so will miss all the sunshine.
My

best regards.
Sincerely yours,
Max Fink, M.D.

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                    <text>July 15, 1987
Turan M. Itil, M.D.
HZI Research
150 White Plains Road

Tarrytown,‘ New York 10591
Dear Turan,
I would be,» pleased to serve on the Advisory Board for Research and
Development of the H21 Research Center for a period of three years.

My best regards.

Sincerely yours,

Max Fink, Md).

Professor of Psychiatry

�</text>
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                    <text>7383~669
Mhy

17th. 1973

The Honorohle Janna Buckley,

Senate Office Building,
Washington, D.C. 20510.
v.

Dear Soother Buckley,

w

—-—~—»v,v.n.r

-wr"

my.-r-v——~.7Hm-—..‘_—..W_

During the poet few years tho President has sought
support for diaeontinoing research training funds. The
impact of this effort on research and teaching in fur
ranching, and Ruprosentativa Paul Rogora has introduced
legislahion to rovursa this Prenidential deoiaion.

I should low like to solicit your support for
56h0, ”The hationul Research and Traineouhip hot I!
1973”. whoa its oqnivalant is introduced in tho Senate.
HR

nv_'-

wrvnwrra

"ﬁlmy-u.

“rs"?‘r‘r

“V

-5

lo

.
.

._.

'v'ApWV&lt;"vr)-..«~WT"¢V‘.VM,.

This bill would raster. research :nd teaching fellowship:
with a) a ceiling on tho total amounts to‘he spent. h)
a proviso for a return of two years of service for every
or three years of support.
you: of mop-orb and c) a.
Such provisions should ovaroomh most of tho objection: to
the pruvious yrograml.

we

This bill would allow continued progreoo in the
devolopuont, through research, of safar and more effectivo
drugs for treating various illnonoen and for the heat
applications of drugs for tho treahnont of patients by
pruchioing physicians. These are matters of concern to theta
of us who consider ourselvns as clinical pharmacologists,
but in the broadar View, this bill rill assure a continuing
flaw of researchora and teachers for all fields of medicine.

.—

Thank you

n

.

for your courtesy.
ﬁinooroly yours.

'W‘m’I-nmwzlvvx

&lt;

n—

r
-

Fink, M.D.
Professor of Psychiatry
Mn:

W:

vaqun»

WW

.v

MF/iJ

�</text>
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                    <text>w‘W‘I—vw-v-x

w v~--

emw-wrn w

rwgm.u—w~—.-rwm

‘....~.‘.

n-y.....w.mv~m~~r~r»mw.-—«um-=.m "1......” q-rrw.“

V.

_,

..~ ...

‘&gt;-v‘r.'l"—

m--. rm... new

.

.

m.-." ...

WW..."

,,...,. . -

m.-

—-

.qVUIIF-ﬂ-W‘I‘"

October 20, 1973
-..mq-.

..A

John R. Hughes, M.D.

The Medical School
Northwestern University
Chicago, Illinois 60611

Dear John,

it has taken to review this volume.
I
to assess the meaning of the
began
until
It
two sections that interested me. I found myself reading and re»
reading the sections, and then it was a difficult decision, whether
I regret the time

seemed so easy,

to

be general or

specific.

I believe the review is too limited-— in part because
I am not well equipped to assess the other sections. For the
opportunity to review the Elul and John sections, however, I

thank you.

~

n.-)'.,r~

«ma»:-

Many

thanks for the invitation and the challenge.

1.7.:

«771'—

Sincerely yours,

“away-WM

W,

W

In:

awn-112M

Sw'W‘r'Wo

.nxrz'

_

WNW""I‘

Max

Fink,

M.D.

v

.

V

m

.

..

.,..,‘..

�</text>
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                    <text>7&amp;1-0331

18 January 197A

Miss Carol Havana
8AODAP

726 Jackson

Place,

H.W.

Wanhinston, 3.0. 20506
Boar Miss Havana:

lcttnt: from Dal" indicating
on banal! of DA 428 005 (SAODAP
Coop-rativc Gltﬂienl Study of LAAM and Hichndonn~~Axthur 23kg)
at.

Enclaacd

coping of two

that tha assuranna submitted

bu: bnan aecopcud.

I trust that thus. latter. complete

this anpcet of

Dr. Zaka' study.

yob§ £110 rcgnrdina

Sincarcly yours.
HI: Fink. H.D.
MF/cis

m1.
ac:

A.

Zakl,

M.D.

�</text>
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E

s

E

‘1Wr"mm*’“’m“‘"'7'

an

Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the newspapers is experimental and
I know of no center near you. The closest may be the University
of Chicago Medical School, and I suggest you write or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman in the Department of
Psychiatry.

Sincerely yours,

pmww—vw'uwrrw'

Fink, M.D.
Professor of Psychiatry

Max

”wwwqy‘xwmm’rm

W

.
v

M,

rm...-

my

.r'w'

V

Mszt

�</text>
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Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the
is experimental and
I know of no center near you. newspapers
The closest may be the University
of Chicago Modical School, and I suggest you write
or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman 1n the
Department of
Psychiatry.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MP

:kt

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1, 1965

Dim

Mrs. My Jawbius,
Academia Book Exhibits
1:036

Poplar

smut

Fairfax, Virginia

1343:: Mrs.

.

220 30

Jambiw:

writing
mhﬁm to the forthcoming 6.1.3.13.
a
Wamdmmmmtofamimdbmkandjmal
1::

_I

I would appreciate your listing the following velm
nomtly publish“ and specifically related to psychophm—
wlogical moardu

exhibit.
as

'

max
A

in

Fink, H.D.r

Selected Bibliography of Eleetmenmphalogmphy

Hm

Psychophmmloy,

1951-4982

196%

Elsevier
Sincerely youm ,
Fink
m
Professor of hymiatzy
’ M. D

‘

MF:jm

O

‘

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                    <text>Hiy'zl.

1964

Mr. ﬁstula J. Jacobs
1111 ratkodgo Lana Hist

Univnrnity City, Hiauouri

nun: Mt; Jacobs:
We

would ho vury plansad

to constant an application tram your

daughtct for position at this instituta. This is tha reseatdh
and training «cater for tho Division at thtnl Discasan of tho
including
Stat. of MinnonIi, and ﬂu haw: clinical facilities chase
in
150 patienta, upccialitcd laboratorial, including
and
othar
ftcilitiea
payehology,
and
exyerinnutal
clinical
noeeosary for a tuuoarth

ctntor.

‘

In the cvnnt your daughter uuuld 11k: to write before sha cone:
to St. Louis, I should be glné to hear from her.
Sincnraly yours,
ﬂax Fink.

Dirnctor

lit/5b

M.

D.

�</text>
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                    <text>JUly

6,

1967

Dr. Ralph Jacobsen
Associate Medical Dimctw

Endo laboratories Inc.
1000
Avenue
Garden City, New York 11533

mm

Dear Dr. Jaoubsen:

I

pleased to armless the Statement of Investigatar,
of the ms, a copy of the protocol and assorted
other docmmnts in support of our mlmaone study. The patients
am almady selected and as soon as these are filed with the
am

Form 2513

PDAandmhaveasupglyofmlomm,wewillmdertakethis
study.

If them

are any suggested mdifications of the prutoool

Imldbeplsasedtorwfrmyou.

Sincerely yams ,

Professor of Psychiatry

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                    <text>Soptomber 5, 1967
Dr. Ralph Jacobson,

Associate Medical Director
Endo Laboratories. Inc.l
'.l000 Stewart Avenue
Garden City, New York_ll§33 [
.

Dear Dr. Jacobsenzv

'

Thank you very much for the initial supply of naloxone
20 mg tablets. Qur
two patients are now.taking 100 mg
a day and the second group of'threo patients will start on
Monday. If all goes well, we.will neeo an additional supply
by the lst.of October.

first

‘

.

Concurrently we have carried out our acute naloxono
experiments_using the_0.4 mg per cc Concentration. Haloxone2 mg offeCtivoly blocks_20 mg of heroin.
I an anxious to
continue this work and will soon need an additional supply
of injectable naloxone. hopefully at.a higher concentration.
I would bo-grateful if an additional supply could be made
*available. Please call me when you have some information.
_

Sincerely yours,
“1-

#rofessor of ﬁsychiatry

,1"

Iu-‘I‘vr‘rf'

I

.,,,mv,.-,w~v-u,y~,.

..
y

.

MF:kp

.

�</text>
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                    <text>mgwxmwmwmva. :11‘

,mv'lmsmurn‘vr"&gt;m—cx-.

m

“wmq‘wm'n

rpm yaw...

...

.....mx-wv-v

,‘4

.7.”

.r—wugn-Wﬂq-r

_

November

Dr. Ralph Jacobson

Associate Medical Director
Endo Laboratories. Inc.
l000 Stewart Avenue

Garden

City.

New

York l1533

Dear Dr. Jacobson:
Dr. Freedman and I are pleased to join you and your associates
on Wednesday, November 22. Unfortunately, both he and I have
commitments in the morning that would not permit us to arrive in
time for lunch and would prefer to meet about 2:00pm.

Enclosed are three copies of the summary statement of our
experiences with naloxooe as prepared for the staff presentation

Perhaps. it would be helpful if this were
available to some of your associates prior to our meeting.

on November 10.

Sincerely yours,
Fink, “.0.
Professor of Psychiatry

Max

.»

,»

Tawny-msqu

m-n

l4, l967

MF:kp

made

�</text>
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0r. RaIph Jacabsen
Associate Medicai Director ,
Ends Laboratories. Inc;"
1000 Stewart Avenue
Garden City, New York 11533

ﬂavember 3,’1967’

'

sear-Dr. Jacobsen:
Enclosed is an announcement of the presentation of the‘
naioxone’data at Metropolitan HOSPitaI on ﬂovember 10. Yen
and your associates are-weicome to attend and I hope t9 have
the opportunity to discuss-the presentation with you.

Sincereiy yours.'
‘

Prefessor of Psychiatry
Mszp

'

�</text>
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                    <text>March 28. 1968

Dr. Ra1ph Jacobsen
Associate Medicai Director

Laboratories
Stewart Avenue
Garden City, New York
Endo
1000

11533

Dear Dr. Jacobson:

It

was very kind of you to send me a copy of the report
I think the idea is a very good one and. when
we are in a position to extend the na1oxone studies. I would
very much 1ike to adopt this method. 00 you think that your
chemist wou1d be ab1e to add ribofiavine to na1oxone? I am
sure that we can obtain the f1oorescent lamp suggested and

by 0r. Jones.

;

L

my

in

my

technicians cou1d carry out tests periodica11y.
Again,

New"?

v

my

thanks.

wg‘w/lw.

Sincere1y yours,
‘rvu'w

Fink, M.D.
Professor of Psychiatry

Max
it
E
E

i
E

1’
E

:-

I
E;

s
E

is
F

E

l

MF:kp

�</text>
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          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="97041">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
