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                    <text>.»

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January 23. 1971
Dear Charlie,

Enclosed are mv nominations for APPA membership. For many
of the nominees, a score of A or 5 weans approval; and ? disapproval.
The latter could only have been given in the case where an apolication

was

and I found no references

available

the senior author.

been

'4' if
Is

separately
mailing

a

it possible
from

list.
We

we

available.

were

to focus
thos without ?

I believe

very good.

It is probable that

citation list

which the candidate was
many '3' ratings would have

in

on

the nominees with citation

admitted Chester Pierce

last year;

he

is

lists
on the

missed you in Appen: the weather was superb; the meetings
Try to come next year.

See you next week.

As

ever,

�</text>
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                    <text>July 23, 1953

r'

Subject:

Mt:
Mr.

0.

ATP TN

$29.33-

“6262

w. Holmes

Smewiew, Credits 5 0011005038
Tram World Airlines. Inom‘pomted
1735

Baltim Avenue

Kansas City 8,

Nissan

Deer Hr. Helms:
by

The

want of

$29. 33 on

this office. It is

now

Mt

'IW

H6262

is questioned

being reviewed by the Sales Depart-n

mmofm.Aooordingtommooxdeﬁ1ismmtism
do
and
overdxarge

we

we

not feel

it

proper to pay.

Inmeventtlmtymmauﬁtm findmtobeinermr,

will then inward this

sum.

For the time being. therefore. please do not dm
office. Thank you.

Sincerely yams ,

.
.

.
..,r

.,..

7......«7...

n".

w».

m.

I
rr—w—wmw

.

Hm

.ww

-—

.

-(r

mm.
Director

M. De

this

�</text>
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                    <text>October 22 , 1963

Hr. o. w. Helms

World Atrium,
Tm
1735 Hakim

Inc.

Kama: City. mason-i

Durham Holman“

I

wish

in favor of

to cancel air travel plan

Dr. Hm: Fink, Emauﬁve

mm: no. m0u6262

Director of the Missouri

Imtituta of Psychiatry. Also, plum anneal Gamma ticket
no. T462262 and means balm on meant as sum as

amt
possible.

"

ATP

Immkingmmmsmstcpotoopenamtherm
As the
was
under motlmr

aim (rim

titla.
newt I would like: the

.paidby

u,

dupmit
deposit mfmdod'mm.

If you wish, the ticket stock amount and air travel
omldmainmdortmoﬁgimlnumgr. Iwillboin

amt
tale}: with your local sales office few further dispositicn.
‘

Sincerely yours ,
Max

Pink,

Director
Hrzmlg

H. D.

�</text>
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                    <text>0mm»

Hr. O. H.

23, 1983

Pblm

Tim: Starla Airlima. Inc.
1735 Baltimn
Kmm City. Miami

m. Kala-u
Attache! is and:

Dear

”8% than the Psychiatric Panama:

Fmdatim

deposit
1'qu
Contact.
Alan AW m tho necessary femswam
mallardng this mm.

of Minna-i in tho mount of “25.00 mic}: is thn
man:may Mural Air Trawl Plan

Sincerely yours.

arm

m.

Pink. H. D.
m
Bamtiva Directar
‘

�</text>
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                    <text>June 20 , 1967
Mr. Larry H. Holswade

sales Engineer
Contml Data Corporation
St. Innis District Sales Office
222 South Bemiston Avenue

St. Louis, Missouri

63105

Dear Mr. Holswade:
Enclosed is a signed agreement for equipment service for
the rental of one 217 Remote Inquiry/Retrieval Display at $380
per mnth, scheduled delivery date of ll—l~67, as arranged by
Dr. Donald Shapiro and following “the quotation of June 1, 1967.
The installation charge is to be considered as rental and
will be paid as pain: of the rental charges during January 1988.
This CRT display unit will be part of the IBM 1800 installation now in the m analytic facility of the Department of
Psychiatry at 5 East 102nd Street (8th floor, Room 37) and is

supported by

USPHS

Thank you

grant

MEL-13358.

for your cooperation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

F. Haydn Mergan, Vice President
Research Administration

�</text>
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                    <text>1-wvn-

May

W
Mom

Holt

Albany.

York

Dr».

23. 1966

of Psychiam

Now

M8111.

IWWMwatMWWﬁaqmdmsmch
mqulam
ymmiudinmmmntkmﬁcﬁty.
mmlwﬁjobinmhtingwmmmﬂummlhiatmyof
studies,
meadow remand
Walt
new
Iwmmﬁlmabhm
Madman.
on the

your

mﬂmmmll,MIfeltﬁmtﬁmWﬂutm
mmMYMmmoiwfﬁciemdcpthmmvidemW
mmwmtywummﬂmtmymmiw
Mlhndtimtommr.
Wsmmtsmuking
Perhaps

itwinbepmsiblotowmmmﬁcrsmdiesmceagam‘

fwsmlyithmimmtﬁmﬁammmty.
Again-L. 21y

distim.
Simmly ma,

thwks for your kind

W
HM

PM,

Man.

of

madam

�</text>
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                    <text>'

June 30, 1978

Gilbert Honigfeld,
Sandoz, Inc .
East Hanover, N.J.
Dear

Ph.D.
07936

Gil,

In 1971, when I first became acquainted with the pre-clinical
data on mianserin, I found that the first human trial had been done
in volunteers, and as part of a Ph.D. thesis, a young investigator
had used the OFF procedure and had found a marked decrement in fusion
threshold with low doses of mianserin. It was 13% data, more than any
animal data, which led to the EEG trials and the finding that mianserin
did, indeed, have a specific EEG profile. The rest is history.
Since 1973. I have included OFF data in every EEG study. So far,
using rather simple procedures, we have been impressed that CF? rates
change in a dosearelated manner whenever we are studying active compounds.
The mianserin data was published in our pharmacodynamic report in
Psychopharmacology (2&amp;z2h9-25h, 1977). We use a simple monocular
fusion procedure with three determinations of the ascending and
the descending flicker threshold, averaging the results of the six

trials.

I was impressed with your elegant procedure and would like to
replicate it. I am confident that active drugs will show their effects
on the more sensitive procedures, like CFF, if they affect brain
function. However, the determination can only be gross for classification
purposes, since discrdminations are only possible in two directions. But
as another index for pharmacodynamic studies, we have been impressed.
The mianserin report is not yet does for NIMH. The data are
derived largely from the 1977 meeting on mianserin held in Amsterdam

in October and published as a supplement to Brit. J. Clin. Pharm.,
supplement 1 to volume 5.
My

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>smmw“tn mus»:.-.

‘

'

,

w“.

,

S

e»

c",

,

“mum -;~hw;'vyw7——wa' m-wamm.

u

—-——

;.‘m'

,

,

.

-s—v—u

March 20, 1989
Ms. Amanda Hopkins-Alexiadis

Psychiatric Institute, Fort Worth

315 Eighth Avenue
P.O. Box 69
Fort Worth, TX 76101

Dear Ms. Hopkins-Alexiadis,
in response to an inquiry by Ms. Robin Moore for a survey of ECT practice
and accompanying training at PIA hospitals in Texas, 1 indicated that training was
best provided at the two established courses at Duke University and SUNY at Stony
Brook. The SUNY course is a five day, ‘hands-on‘ course which is taught by six
members of the faculty. intensive sessions discuss clinical indications, ECT
techniques, nursing care, anesthesiOIOgy, medical aspects, instrumentation, theory,
and consent. (A description is enclosed.) Such an intensive course cannot be
duplicated outside our facility at this short notice. Therefore, we believe it would
be preferable to have members of your staff attend the next course, planned for

mid-June.

But it such attendance is not feasible, we beleve we can create a
reasonable facsimile for your staff at Fort Worth. As it is not possible for any of us
to teach consistently and continuously for the required minimum two or three days,
it would be necessary to include more than one member of our teaching faculty,
and I would invite Dr. Lawrence Greenberg, attending psychiatrist and Mrs. irene
Carasiti, ECT nurse. Both have worked with me for more than five years in our
EC‘l' unit.
'

A program would be focussed on practical clinical issues: indications for

ECT, selection of cases, consent, medical examinations, demonstration of
treatment practice (dosage, electrode placement, frequency), adverse effects and
their management, identification of high-risk cases, and malpractice concerns.
Such sessions would require a clinician to spend time in the clinical facility to
determine the types of cases to be used in the clinical sessions; and to survey the
treatment facilities for ECT. A suggested two-day curriculum is attached.
The addition of a third day will allow sessions for nurses and
anesthesiologists; didactic sessions on ECT theory; discussions of the role of the
consultant, management of the high-risk patient, credentialling and privileging, and
extended applications as maintenance ECT, treatment of adolescents, and
neurologic and medical (mmpsychiatric) applications of ECT.

�Psychiatric Institute of Fort Worth

Page 2

it would be possible to invide Mrs. Carasiti to work with your nurses in
parallel on one of the first two days.
In discussing the facilities now at the Psychiatric Institute, 1 was told that
patients are not now being treated with ECT. We consider a hands-on
demonstration so useful, that every effort should be made to take the students to a
facility where EC? is actually given; or, to allow us to demonstrate ECT at the
institute in suitable cases.

design our teaching to encourage our students to teach others at their
We provide each student with texts, videotapes, and readings to
supplement the textbooks. For the preposed training program, we will supply one
(or multiple) set(s) of the texts and videotapes at our discount of $405. A set of the
supplementary readings is duplicated at the nominal charge of $10 and either one
or multiple sets can be provided.
We

institutions.

We have not developed charges for such an off-site training course but are
prepared to use the fee schedule for off-site patient consultation and court
appearance as a reasonable basis. We will set a ﬁlly fee of $2,000 for each of the
psychiatrists and $1,000 for Mrs. Carasiti. in addition, travel costs at first class
rates and local hotel and meal costs will be charged as paid.
We

can deveIOp this program in the period Sunday-Wednesday, April 23-26.

can be reached at my office most mornings at 516-4411 2929. Our FAX
number is 516- 4% 7534. I trust these ideas are helpful, and thank you for your
inquiry.
1

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�1

Psychiatric Institute of Fort Worth

“w

Page

PROPOSED COURSE: CLINICAL ASPECTS OF ECT

w»

Dag (-12: Preparation afternoon/evening
er.—mw-w

Yewwm—uy.

Visit treatment facility; review charts and interview patients in course of
ECT, being considered for ECT, or recently completed ECT. Interviews with other
patients who may provide bases for discussion. Visit ECT treatment facility; meet
with ECT nurse] physician] anesthesiologist. Plan actual course with project

coordinator.
Day

i:

am. indications for ECT: didactic; patient interviews; videotapes. (MF)
p.m.

l?

Pre~treatment examinations (LG)
Technical issues in treatment; instrumentation; electrode placement (LG)
Discussion of risks; risk management; malpractice issues (MP)
Consent (LC or 1C)

a.m. Treatment demonstrations (MP, LG)

w

wvn

pm.

mm—

~.-

—.-

Nursing and anesthesiology questions (LG)
Frequency and number of Rx; indications for termination; concurrent and
sequential use of drug therapies (LG)
Maintenance ECT (MP)

m-w—n-

-

4

-—w—-

ymvw

y.

Do! 3:

am.

Medical issues; high-risk case management; role of consultants (LG)
Other indications: Neurologlc; medical (MP)

pan.

Concurrent sessions:

a...

Nurses: Role of nurses in ECT (1C)
Pre and Post-EC! management

Consent procedures
Group therapy for patients

Anesthesiologists: Medical risks of ECT (LG)
Pre-ECT examinations
Ultra—brief anesthesia
Airway management
High risk medical cases; pregnancy
Physicians: Theories of ECT (MP)
Credentialling and privileging
Malpractice issues
instrumentation
Continuing emanation for professionals
Community education

WWW.

3

...

v...-4v.w-u».r.-~.-,. ..-,

.1

_,

.7...“

�Psychiatric Institute of Fort Worth

Page a

Training Materials

BOOKS:

Fink, M. CONVULSNE THERAPY: Theory and Practice, Raven Press,

1979.

‘

American Psychiatric Association: Task Force Report #14, Washington,

D.C., 1978.

Abrams, R. ELECTROCONVULSIVE THERAPY. Oxford University press,

1988.

Malitz, S. and Sackeim, H. ELECTROCONVULSIVE THERAPY: Clinical
and Basic Research Issues. New York Academy of Sciences, New York 1986.
JOURNALS:
'CONVULSWE THERAPY, Raven Press, New York. Quarterly.
VIDEOTAPES:
.

Bluff,

INFORMED ECT FOR PATIENTS AND FAMILIES. Somatics Inc., Lake
1986.

11.,

MIND AND BODY. Health Information Network. Distributed by MECT A
Corporation. Portland Oregon, 1987.
*'

SUPPLEMENTARY READINGS IN EC?

The set of books and videotapes may be obtained at our cost of $475 each. The
supplementary readings can be duplicated here at about $10 each or we can supply
an unbound set for your duplication.

�</text>
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                    <text>August 2, 1991
Robert P. Hopkins, M.D.
Chairman, Credentials Committee
McLean Hospital
115 Mill Street
Belmont, MA 02178-9106
Dear Dr. Hopkins,
I am pleased to write this letter in support of the application of Morton
G. Miller, MD. for the professional staff of McLean Hospital. Mort was a
member of our Department at Stony Brook for more than a decade under the
leadership of Stanley Yolles, and I knew him as a co-worker and unit chief. Mort
came to Stony Brook with Dr. Yolles from NIMH. In our Department, he was the
organizer and leader of the in—patient service, and I worked closely with him as
an Attending Psychiatrist.

Mort is an excellent clinician. He is skilled in clinical descriptive
psychiatry, and an excellent psychopathologist. He was instrumental in defining
the group of manic patients who come in a state of delirium, and who are
immediately responsive to ECT. He organized our affective disorders program
and the lithium aftercare clinic. In this unit, he inspired a number of his juniors
to credible research (Aronson, Shukla) with excellent publications.
He is an excellent and well organized teacher. He knows the academic
literature, including much history, and is able to lecture in an inspiring and
thoughtful manner.
He is a fine administrator, and is well liked by the professional staff.
He is honest, thoughtful, and adheres to the highest principles of our profession. I
am not aware that he has ever been denied any professional privilege or
membership which he requested; nor has he been denied licensure. He stood
before our tenure committee and was promoted to Full Professor with tenure in
due course. He is rather abstemious in his use of alcohol and there has never
been a hint of drug use.
I have no hesitation in recommending him for full professional
privileges in psychiatry, and do so without reservation.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

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                    <text>February 1a.

1965!;

Dr. F. Homung

East St.

3120

State Street

Inuit. Illinois

mar

Dr.

Emma:

I have received a letter of inquiry from Dr. Hemt Flagel
of Dusseldorf. mark you vary mm for mferxing him to us. A
oarbm copy of ﬂy letter to him is enclmd for yam infmﬁm.
As can be seen, it is with same regret that I met indicate that
for a clinical pmitim, the satisfactory completim of the ECM
is mquimd. However, I would be «ligated to have him work wiﬁain
our laboratories and if m is interested in such an opportmity. I

*

ﬁrinkitwmldﬁwhimthedmmtoviaitﬂwsmtesandtoleam
something abwt our 13mm.
It muld be helpful if you would sand m a letter of memmndatim regarding your acquaintanca with Dr. Real and my informatiauthat ym m be willing to share with us mgamding his
mammal:
his academic emﬂeme, and his ability to get
along with other scientists.

Mats,

man}: you very and:

for your mmdatim.
Sincemly
Mu

fink,

Erector
16:13.13

ﬁne. 1

yam ,
H. D.

-

_

�</text>
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                    <text>Twwwwm

March 28, 1968
Dr. Zola P. Horovitz

Squibb

Institute for

Georges Road

New

Brunswick,

How

Medical Research

Jersey 08903

Dear Dr. Horovitz:
I very much enjoyed having lunch today with you and the
other members of the staff of Squibb. As I mentioned, I am
enclosing a copy of a report which I have just completed and

submitted for publication in the Proceedings of the
I think this reflects my present position.
I would

ACNP

appreciate receiving a copy of your report in

the l966 Proceedings.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszp

l967.

�</text>
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                    <text>7383-81553

13 December 1973

Sidney Marlin, M.D.
Rsaosrch Division

Station H
Csntral 1011p,

New

Ybrk 11722

Dear Sid:
Thank you for continuing to send your reprints. The
latest on psychopathology in methadone is of special interest
to Don Swanson.
to us and I hsve sent

it

I would spprscistc your changing your address of record
from New York Msdicsl Cellos: to Stony Brook.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/oia

�</text>
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                    <text>Dr. Richard Horton

February 3, 1996

42 Bedford Square
London WC 1B 3 SL
United Kingdom
Dear Dr. Horton.
I read the essay ‘Revising the research record’ with much interest and
sympathy. As editor of Convulsive Therapy, no problems of scientiﬁc error have been
brought to my attention. Our level of error has been at a more triﬂing level, and so we
have not been faced with the difﬁcult decision as how to alert the readers to scientiﬁc
error. I am impressed that the Table ‘Taxonomy of error’ in your essay reﬂects the best
stande available today.
Since a published report has gone through the journal’s peer review, when
is
found
error
or charged, it seems logical to go through the same procedures to establish
error. Assuming the review concludes that error of fact or procedure occurred, such
conclusions warrant publication. The suggested ‘withdrawal of aegis’ by the journal is a
reasonable and innovative step in maintaining scientiﬁc integrity. The principal downside
risk is the assurance that the material presented the readers in the ‘withdrawal of aegis ’ be
complete and able to withstand procedural and legal scrutiny. The guidelines for authors
should reﬂect the possibility of such review of published material and the possibility of
such published revision.

Should you wish a publisher’s point of View, Dr. Alan Edelson, the founder
of Raven Press and the former President of Lippincott may be able to answer an inquiry
more formally than I [amedelson@aol.com;or 16 Washington Avenue, Irvington NY
10533}
Incidentally, I have stepped down as Editor of Convulsive Therapy, but am
still interested in the problems of editing and editors.
My regards.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>March 7, 1966

Dr. William A. Horowitz
(maxim, Graduate Bducatim Ommittce

New

York

722 Welt

New

State Paycmatric Institute

168th Street

York, New York

Dear 8111,

In reply to your letter- of
2, 1966 regarding my
association with I». Ian-y mmhith
in conjunction with his
application for maidency training in psychiatry, I first
out Do. lyycobmnhe mscmdicalstudantchminga
fellomhip at the Misaom‘i Institute of Psychiatry. Atownerthat
tin», we had just cstahlid‘nad an evoked potential laboratory

‘

aspavtcftlumumphyaiolcgypmmandmaasigned
Dr.
Mycob to this study program. Without pmvims experience
in electronics, In soon bacon» acquainted with
the» equipnent
and construed facility not ally in
eliciting
evoked patenting. but in relating to patients and recording
as well. He
spent a portion of his time «1 our clinical services
and
shomd considerable interest.
the
we
Mug
period,
felt his
to be satisfactory. Since that time, I have
follovcd his cameo with intomst .

amr

m

is a personable, friendly, and perceptive
life with panama and self pcssessim.
Implaaoad to mmdhimfcradvanmd
trainingin
paydz’iatzy,
believe
Dr. Laycob

yang man

as a

who

appmadmeo

as

mom

I

that he will catablish himself
practitioner.
Sincerely yours .

Fink, M.D.
Professor of Psychiatry

Max

Mfﬂcp

�</text>
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                    <text>'46
,v

“.5.

«mam

u;w.-v:w.g-n,

pt‘m"

..

a
1291‘

'

vi

svmvrnw

'2-

“mrm-

“'55

75““

Dr.

Jam 16, 1967

Edmond 8. Have

Institute of

Hanan Learning
22M College Avenue

Berkeley, California

9M720

4‘

‘"TI'EM'FW’IM

w-‘H‘s

.wgﬂzrzm'v

w-

m

”squares;

1

DearDr. Hale:

IamplmningtobeinSanancisooonSatuxﬂay,
28 and leaving on the 3131:. I will be attending
meetings at the medical center in San ancisoo and will
be staying at the Fairmont Hotel. The best time to get
together might be late Saturday afternoon or Sunday afternoon after the matings; If you will let me know where to
call, IwwldliketooallyouonSatumayafterlarrive
January

and

set a definite date.
Thank you for your-interest.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬁcp

A

�</text>
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                    <text>I».

2mm

8.

Howe

Institute of human

mm

m

29, 1968

Lhiversity or California

College Averm
Berkeley, California M720
221.1

DearDr.

W:

Dr. Joseph Jaffel’nstoldmeofyowintmst inretuming
toNewYork, ardhassmtmeyummimlmnvitae. Ihave

madthiswithintemstandanwrithntomggestﬂatinthe
available.
present

Mof this deparunent, apositionmayhe

Wt
Widow

of Psychiatry has recently mdergone an
based
on the
explosive growth
developmt of a
Community Mental Health Canter, an enlarged residency training
and most recently
progrm, laboratories in basic
The Deparmont

aseriesofclinicalrasearchprograms. Itisinthelast
‘developemttMtIravebeendirectlyinvolved,endhaverecently
accepted the position of Clinical Director for the facilities at
hetropolitan Hospital.

TMeearetheDepartment's clinical facilitiesbothfor
mseamhandteaching. Immedwstoreommendanexperimental
,

peycrologietfortmpoeitionofaxiefofl’syotolow.

position requires a minimal mount of

The

ministrative respmsibility,

chiefly in relation to the supervisim of the psychologist assigned

tovariousdeparmexrtalprogmgmdaeadvisormtrnolinioal
directorinthepmblensofpsycrologyastheyralatetothese
progress. 'memajor-ityefeuchmindividual'stﬂaemﬂdbe
devotedtotlutrainirgprcgrmofpeychiatriomidmtsand
Indical smdents.asa1dviscrintheolinical evahatim prom,
kg

1.

andinmdertekingexperimentalresearch.

‘

.‘ue-

.7,

”3“.“

Ifwchanopportmityinteruﬂyomlwwldliketomxge

thatmmeet. Istlmsoeeoypomunityforyoutobeintmﬁast

dwingthermctfewweeks?

Ifmt,itisprobablythatlwillbe

inSmftancisooattheendofJanueryandeouldbepleaeedto

meetwithyouthen.

Sincerely yours,
Fink, PM).
Professor of Psychiatry

Max

�</text>
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                    <text>DEPARTMENTAL CORRESPONDENCE
DATpecczml r37;
SUBJECT

Consultation Fee

To

Mrs. Howell

.

~

Martin

A.

Green,

13, 1962

M. D.
DEPT

Hospital Bus. Mgr. Assistant

Dr. Green actecl as an ad hoc coz'lsultant for me in the employment
of Dr. Mawgerison. He interviewed Dr. Margerison on November 30th
and then discussed his recomendatiom with regard to the
employment of Dr. Margerison as a neurophysiologist at the
Institute, with me on December 7, 1962.

is a part of the Missouri Institute of Psychiatry's
recruitment expenses.

This

�</text>
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                    <text>August 1, 1968
Mrs. Virginia Hoyle

Assistant Editor

Annuai Review of Pharmacology
4139 E3 Camino Way

Paio Aito, California 94306

Dear Mrs. Hoyie:

Enciosed is our manuscript “EEG and
for the Annuai Review of Pharmacology.

Human

Thank you for the opportunity to prepare
I hope that
meets with your aoprovai.

it

Psychopharmacoiogy“

this

summary add

Sincereiy yours,

Professor of Psychiatry
MF:kp

�</text>
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FWVlmVr-z

November 17, 1981
Dr. Richard A. Hrachovy, MD.
Department of Neurology
Epilepsy Research Center
Baylor College of Medicine
6516 Bertner Avenue
Houston, Texas 77030

Dear Dr. Hrachovy,
l was sorry to hear of the problem in patient recruitment. The amendment

is acceptable end has been filed.
to the
enclosed for your records.
1ND

A

copy of the letter of submission is

if you are coming to the ARNMD meetings in New York in December,
perhaps we could meet ? i plan to attend the afternoon session on Friday and will
look for you at the registration desk at the end of the session.
Good luck.

Sincerely yours,
raw—r

Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>August 24, 1964

K. N. Hsieh, M.D.

Eastern Oregon State Hospital
Pendleton, Oregon
Dear Dr. Reich:

for your inquiry. The iissouri Institute of
Psychiatry is the research and training center of the Division of
Mental Diseases of Missouri. It was established in October, 1962,
with laboratories and clinical facilities for research. At the
present time. of 150 beds. we are utilizing 70 for research pur~
poses. Laboratories are established in pharmacology. psychology.
and electroencephalography, as well as a computer center for both
statistical and EEG analyses. There is a specialised psychiatric
research library as a component part of the Institute. Animal
facilities are now being built and will be completed by the end of
the year.
Thank you very much

'

*

there are a number of research programs in
These
Lithium as a therapy for mania; the use
include
progress.
of Yohiohine as a precipitant of anxiety and the development of anti-

At the present time,

anxiety agents; relation of EEG patterns and organic factory in the
treatment of therapy resistant psychotics; computer analysis of the
electroencephalogram; the effects of drug withdrawal on behavior in
the chronically ill; the evaluation of new psychotropic drugs is
part of a national early clinical drug evaluation program.

In neurophysiology. we have the following magor programs: evaluating
the EEG changes withvpsychotropic drugs and relating these to the
behavioral results; a study of the cortical averaged evoked potential
and determining the interrelationship between different methods of EEG
analysis and efforts to quantify these, and to relate these changes
to behavioral changes as reflected in psycholinguistio methods.
At the present time. the Institute is planning to expand these programs in the coming year. We are inviting the collaboration of scient~
ists whose interests are compatible to our own and who wish an opportunity such as this institute provides, and are pleased to consider

applications.

�Dr. K. H. “Sigh
8—26-64

Pugs Two

I

would appreciate a copy of your curriculum

vitae, listing

chronologicilly your education and professional axporlance.
In addition. a small photograph and the names of at least two
referaes to whom wu may write would be most helpful.
Sincerely yours.
Max

Fink,

Director

143/11:

M.

D.

�</text>
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                    <text>7383~62h

April 16, 1973
Dr. P. Gilbert MbMEhon,
Read, Therayeutlc Section.
Departmcnﬁ of Medicine,
Tulane University School of Modtetno.
lhBO Tulana Ave..
new Orleans, La. 70112.

a

"warm-w?!"

nn—uw

man

"'meth

1:21am

I

.2

g

Dear Doctor Mhﬂahon,

is a statement from the Harriett Mbtel. It
underntandlng that this would be paid by the master
account.
Enclosed

was my

,

If that is incorrect, please send it back to
will arrango far payment.

me

and I

for your kind invitation and for the
ylctures which I received this morning.
Thank you again

Sincerely yours,

Fink,
Professor
max

Mylié
Baa.

M.D.

at Psychiatry

�</text>
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                    <text>March 5, 1979

.

Dr. L. K. George Hsu

St. Getrge's Hospital Medical School
London, England
Dear Dr. Ken,

for your inquiry regarding a position in this
laboratory. At this time, we have no openings, but I will keep your
application on file in the event our situation changes.
Your interest as anorexia nervosa is of-special interest
Dr. Michael
to me, and in this regard, I any suggest that you.write to Chicago
of
Psychiatry,
Department
Taylor,(Chairman and Professor,
medical School, VA Hospital, North Chicago, Illinois ‘6006h). He has
an interest in the same condition and may have a position open.
Thank you

In the recent literature on anorexia nerVOsa,

'

it

has

been unclear whether the vegetative disturbances, particularly the
evidence of hypofunction of the hypothalimo-pituitary axis, are primary
loss. In a recent
to the disease or secondary to the anorexia and weight have
come to the
others
we
ECT,
among
of
analysis of the mode of action
ECT
stimulating
in
much
of
the
is
process
of the thrust
conlcusion that
substances.
hermenal
of
release
axis
to greater
the hypothalmo-pituitary
respond
should
anorexia
nervosa
with
'If this be true, then patients
well to ECT, and the-evidence in the literature are that they do. However,
unable to find any
the reports are clinical and anecdotal and we hare beenanorexia
nervosa. In
ECT
of
the
course
on
of
sytematic study of the effects
the
7
share
can
ECT
you
received
If yes,
your studies, have any patients
schedule,
treatment
hormonal
status,
date with me- state of subject,
outcome, etc . ?'

If this

problem

interests you, perhaps

you could apply

for support for such a project in a center where such cases are available
(as in Chicago or Iowa City)or New York), and defray your support by this
A

mechanism.

I trust these

comments

are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>DEPARTMENT OF EXPERIMENTtL PSYCHIATRY

July 19, 1962
Dr. John Hubbard, Exec. Seo'y.
National Board of Medical Examiners
133 S. 36th Street
Philadelphia h, Pa.
Dear Dr. Bubbard:

I am requesting liconauro in the atato of Missouri
the basis of oortificition by the National Board of
Medical Examiners. A photocopy of my certificate, 1&amp;562
is appended to the application.
Pleaoc complote section 21 and return to mo for
on

filing.

Thank you

I

for your cooperation.
‘Sinooraly yours,

MFagp

encl.

Max

ﬁInE, H.D.

�</text>
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                    <text>May 27 ,

up.

mum: make].

Key

mt.

621 Dwal

Street
Harlan

1969

33mm

mm.m1:

Wlwbesynpaﬂnticmﬂnpoaitimmﬁchyou
mnemxding,1doobjwtintheuseofny0pinimin

thfuhimuhichywmmqmstim. Sinoemysmemnt
rm."

1v“-

-;-n-w-gw"u

Max

Mszp
.1)”,

.,

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l-varrmwr

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m1w*‘m'mw

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1-‘1'

Fink,

M.D.

Professor of Psychiatry

«WW-nan

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                    <text>. -~,~..~.vr.v1\-—..,m“MW

57,...

wv'tnAs-

,;

w

:....---n

m..-

’7.

up t:.w..w;.~.wm—.'Anurw"n

r

wmnmwy,qw.m. hm.

. _,., “w..." »'v--v6‘vr-".'"."

1—5. :‘

,‘V

--

,-

v

'v

-.4~,~

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4

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vamwwu

N

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wv

Decsmber 11, 1975

~qu

Dr. William Eudspeth
Division of Behswiorsl Sciences
Medical School
University of Hsvsds
Rana, Nsvsds 8950?
Bus: Dr. Budspoth,
Enclosed are two of our latest reprints. Most of the
work can bu found in the summary report.

citations fur our

If s special aspect of this work interests yau, I
will be glad to sun's: s specific inqniry.
For s mare general rcviev of the problsn you may wish
to gut tbs vnlnmn edited by Dr. Itil. tram which this chapter is
abstracted.
Thank you

for year

intsrlst.
Sincsrsly yours,

‘

ur/nr
Enos.

Fink; M.D.
Professor of Psychiatry

Mix

~r—

�</text>
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                    <text>May

16, 1963

A. L.
m.
#8 Outer Lama Road

St. Louis 81,

mar

Mrs.

mm

‘

Hams:

kyltakethisopwmnitytommlauwumm
election
as President of the Puma]. Health Association ofSt. Louis. Hywifemlhoﬁaludanmusuallyplmt
evening last night at the dinner, and 3mm addrws was
43mm.
Imuldbeymmmtakeyouﬂamughﬂnlnsﬂmmm

the occasim of your next visit. I swam also be phased
if the Board of the Mental Health Association would Wide)?
holding one of its meringue“: the raw Institute. Ch such an
I should Luca to taka the opportmity of providing
mama,
yew associates with a similar opportmity to become acquainted
with this naw facility in St. Imus.
'

.

Hy

,

best wiains for a snmssful year.

SW11; yours,

HFsaw

Fink.
m
Dimetor

M. D:

-

�</text>
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5

November 5, 1970

Senator Harold Hughes

U.S. Senate

Washington, D.C.
Dear Senator Hughes,

Just a letter of congratulations on your efforts on behalf
of more effective drug abuse laws. Your efforts in reviewing the initial
bill hastily passed by the Senate, and the final bill, represent a
more rational approach to drug control. I hOpe that your suggested
center will indeed come to pass, as it will do much to improve the
quality of the research in addictions.

efforts at developing a successful long—acting antagonist
are proceeding, albeit slowly, and with some optimism. There is still
too little leadership in Bethesda, but we will succeed.
Our

Again, congratulations on a job well done

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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wwum-m,

“rm-Wm

February 4, 1971
Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medicel_School
303 East Chicago Avenue
Chicago, Illinois 60611

"W'

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;rurgxwwﬁew

Dear John,

:rv

ﬁre-tart»?

«1"

Enclosed are two copies of my review of "Brugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.

I
Nth—5.3

ammunzw,

made me

Thank you

read

it

for the Opportunity to revtew this volume carefully than I might have otherwise.

more

it

Sincerely yours,

_

,

award“

“"1."

vzsr'ww

Fink, “.0.
Professor of Psychiatry

Max

W

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“Th7!"

Mszt

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‘1

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�</text>
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Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medical School
303 East Chicago Avenue
Chicago, Illinois 60611
Dear John,

Enclosed are two copies of my review of "Drugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.
made me

Thank you

read

it

for the opportunity to review this volume more carefully than I might have otherwise.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

it

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                    <text>.~
v
V

'1'.“

v-

mmc'rm‘mr

'

7333-5330

April 19. 1973
Dr. Richard Abram: .

1h2 Columbia Heights.

Brooklyn,

ELY.

Dou- 10101:,

I have reread your contribution to the EST
volume. In the: context: of tho two reports by Banter,
copies of which arc ”cloud, it might ken thc
value up to date you would add a. postscript,

footnote. or s
the contaxt of
of course, add
place. If you

would be most

it

paragraph, placing their work within
your review of multiplo ECT. We will,
the (citations at the apt-mint:
could do so within the next. week. I

grateful.

w but regard...
Sincerely yours ,.

m: ﬂak.

14.9.

Profane:- ot Psychutry
MI 13
Enos .

�</text>
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                    <text>7383*74483

17 October 1973

Mr. Konnoth B. Stohl
Box 1522. Station #2

Amherst, Massachusetts 01002
Dear Hr.

stahl:

Thonk you

artiolo to

and

I

for your latter of October 9. Since writing the

which you rotor. I how: loft How York Radical College
am nov at S.U.H.Y. at Stony Brook. Ho do how. o prosron of

research in the narcotic antagonists.

it is not oloar what aspect of the report
principal programs of this Division are in
tho study of the effects of drugs on tho human EEG as well no
spootfic ntudloo of opiates and choir antagonists.
From your

inccroats you.

lettor,
The

Ehould you with to come and visit, I suggest you call my of~
{ice and ottongo to v1.1: thia univoroity. I shall be away until

Hovonber 10, so should you wish

date.

to viait

it

should bu

aftor that

Sinooroly yours.
”ink,
an
Profoooor
HP/cis

HID.

of Psychiatry

�</text>
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                    <text>STATE UNIVERSITY

or

NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
School of Medicine

'1

Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry
13 March 1974
Mr. Stewart Alsop
Newsweek
444 Madison Avenue
New

York,

New

York 10022

Dear Mr. Alsop:

conclusions regarding the use of opiates in dying pa—
tients, quoted in the New York Times of March 5, strikes a res—
ponsive chord. I am a national consultant in opiate research
with experience in studies of heroin, and I am frequently called
upon to answer disturbing questions.
The

Physicians ask whether heroin may be used, its safety, and
their risks are with regard to the Federal Internal Revenue
Service and the Bureau of Narcotics and Dangerous Drugs. I have
to answer that they may not use heroin; that even for research
obtain permission and supplies; and that their
it is difficult toBNDD
IRS
and
fears of
are probably groundless. But I am not sure
about the latter statements, recognizing that in their asking,
the physicians are reflecting a fear that may be founded on

what

history.

Because experience with opiates is limited, they tend to
use dosages that are too small for fear of developing 'dependenee,‘
thereby under—treating their patients. This attitude reflects on
our education and on the proscriptions quoted in our journals.

I have used heroin to treat relentless pain and have found
it is quicker in action, more effective in response, and
has fewer side—effects than morphine. As you have suggested,
the mood—altering qualities are particularly gratifying.

that

Your reference to morphine and heroin brings to mind the

reports that other opioids, particularly etorphine (M-99) have
been tested and are even more effective than heroin; that they
are probably 1000 times more active on a dose basis~—but studies
-1-

�Mr. S. Alsop

13

—2—

March 1974

w‘

.

aha-vat.

are proscribed by authorities in the U.S. and Europe for fear

that the

Afor man.

it

'instantly addicting' and too dangerous
Its use is limited to animals, where (as Immobilon)

compound may be

is used to capture non—feline mammals. (For a description
of its use in patients, see the reports by Blane in Agonist and
Antagonist Actions of Narcotic Analgesic Drugs, Ed. by H. Koster—

litz.

London:

Macmillan, 1972.)

Not only should heroin and etorphine be made available for
found useful, allowed to be
prescribed by physicians for patients with intractable pain;
but we should be willing to make these substances available to
patients with instructions as to the consequences of‘overdose,
so that they haVe an opportunity to self-regulate their dosages
as needed.

clinical analgesic studies and, if

Your

efforts at liberating these analgesics for medical

uses are to be encouraged.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>February 25, 1964

Professor L. A. Hurst
Department of Psychiatry
and manual Hygiene

abdical School
Johannclburg,
South Africa

Dear Profusaar Hurst:

I wish to take this Opportunity to thank

for your letter of
I am pleasod that us

you

reference on behalf of 0:. Aloxander Don.
have boan able to after him an aypointmant at this Instituta,
which ha has accepted. I look forward to having him work with
“30

I

am

mecttng.
grateful for your kind comments regarding the 1961
interested to know thnt a bibliography on EEG and

You may be

Psychoyharmacology was compiled by my ssaaciarcu following
and that this will ha publiohad wtthin the next
few months as EEG Supplement #23.

Human

that wasting,

in addition. tha

1964 mnuttngx of the 61%?

in

B£rniugham,

England. will include I panel discussion on this subjuct. I
trust that the format of chi: a11~day ﬂoating will follow more
of a discussion and inquiry rather than the sequcnca of prenantau
tions which war: made that cvcnina in 1961.
Again,

my

thanks for your kind raeammcndntlons.

sineetely yours,
“3‘ Fink.
Director

mm

1‘!ch

�</text>
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                    <text>M

&amp;

~

“5"”

Dem 27, 1963
Professor L.

A.

Hurst

Department of Psychological Phdicine

Pbdical School, Hospital Hill

Johannesburg, South Africa
Deer Professor Hurst:
Dr. Alexander

14.

Don who

is

now

at the

Warley

Hospital, has

at this Institute as a research scientist.
grateful for your opinion regarding his abilities

applied for a position

I would be
in clinical psychiatry, his relationship to others - especially
his jmiors, and my opinion you may have regarding his possibilities
in a research career.
This Institute is. devoted largely to research in clinical psychiatry
with laboratories in phmoology, electroencephalogaphy, wxputer
sciences, and psychologr.
Thank you very much

for your oocperetion.
Sincerely yours,
Pink,
Director

1433‘

MPzaw

Me Do

�</text>
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.,

W. 7..-..7 .wW—m.-v—- --*

rv1yw'IrwnwmnV w‘mvwwwrm

March

31.

1969

Dr. Allen E. Hussar

Chief, Medical Service and
Associate Chief of Staff for Research
Veterans Administration
Franklin Delano Roosevelt Hospital
Montrose,

New

York 10548

Dear Dr. Hussar:
Thank you for your suggestion of studies of dextroamphetamine
in schizophrenic patients, and the reprint of your work. The
suggestion is very good and should be followed.
Our own program of study is focussed on the effects of
drugs on the waking EEG. This permits me and my associates
to have a more "normal“ family life. There are many workers
interested in the effects of drugs on the sleep EEG and these
include Feinberg in New York, Kales at UCLA and Itil in

Missouri.

an ongoing

I am

sure there are others, but

file of sleep studies.

Thank you very much

I do

not keep

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>g\

December 28, 1971

Dr. Hugh H. Hussay, M.D.

JAMA

535 N. Dearborn

Chicago,

Illinois

60610

RE:

REF:

MS

#3263

Dear Dr. Hussay:
have reviewed the data in our study of “t-Alpha—
Acetylmethadol in Maintenance Treatment of Opiate Dependence”
and find that some of the interesting relationships can be presented in tabular form. We have made up such a table, and it
We

is attached.

it

seemed somewhat lengthy, we indicate a section
that can be separated, and the data presented in two tables.
As this is a matter of style and appearance, we will abide by
As

your decision.

Thank you for your kind consideration. I trust that
the reputed excessively high price of the base material for

will soon be reduced, so that more ex~
tensive clinical tests can be done. Publication of this exper—
ience may serve to stimulate a more rapid governmental and in-

Esalpha—acetylmethadol

dustrial response.

Sincerely yours,
Max

Fink , M.D.

Professor of Psychiatry

bﬂﬁig
Enc.

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                    <text>Dace-bar 28, 1971

Dr. ﬂush K. ﬁuaaay, M.D.

Jﬁwﬁi

535 N. Dcarborn

Chicago,

_

Illinoia

60610
RE:

REF:- HS #3163
7
:\.

Dear Dr. ﬁuaaay:
have reviewed the data in our study of ”i-AlphaAcetylmctoadol in Maintenance Treatment of Opiate Dependence"
and find that some of the interesting relationships can be pre—
sented in tabular form. We have made up such a table, and it
We

is attacﬁca.

seemed somewhat lengthy, we indicate a section
tables.
that can be separated, and toe data presented in two abide
by
As this is a matter of style and appearance, we will
As

it

your decision.

for your kind consideration. I trust that
high price of the base material for
excessively
the raputed
soon be roduced, so that more ex—
will
£-alpha~acotylmethadol
tanaiva clinical tests can ha dona. Publication of thisandexper—
in—
ionco may serve to stimulate a more rapid governmental
Thank you

duatrial raaponao.

Sincerely yours,

as: link, at».

Profaaaor of Psychiatry

anig
inc.

|

8152.

“£45,931

�a

10

Completad 6 Hal.

5

4

4

A

Mean A38 (yearn)

24.7

31.0

28.5

Your: Addiction

7.0

9.2

7'0

Methadone

Methadol
High 2233'

‘

Law Dqgg

t

Behavioral

9

Change Score

l
1
€

(Range 0%1)

+1.2

+1.4

i

+1.5

!

Opiate Withdrawal Symptonw

3/4

a

Secéndar/ Symptoms

t
3

lrritauility

1/5

Jerky Actor Jovements'

1/3

1/4

2/5

1/4

2.02

2.8%

16.9%

7.12

1.72

2.52

10/10

5/5

1/4

0/1

~

Constipation

4/8

i

2/4

Urine Testing
P05.

for

P03.

for Barb1Cutate

Morphine

or Amphetamine
Ho

Rasponsc to IV He:oin
+24 ﬂour

—

50 ug 8

+48 Hour

-

50 mg

H

�</text>
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                    <text>December 29oh, 1972

Dr. Hugh E. Eueeey, M.D.
The Journal of the American Medioel
535 R. Deerborn.
Chicago,

Illinois

Association,

60610.

Dear Doctor Hueeey,

ere-pleased to enoloee a short report "Levomethedylz
Prolongea Duration of Oyioid Effects, Including Crone Tolerenoe
to Heroin, in Man" for your oonnidereiion for publication in
the Journal or the Amorioen Medical Aesocietion. With the
increasing use of methadone throughoui the notion, the incidence
of both overdose of methadone and illicit oiveraion have
increased the imoortenoe of the developoent of e long—noting
we

Opiate

substitute.

This study van undertaken at the request of the Veterans
Administration who, anticipating a more general study of
v:
.-

aw

on

an”;

rm.”

-:;

v

rt’mw'2~rxazmr‘;.:m'co.

‘

levomethadyl and methadone,

felt the

need for detailed

information regarding levomethedyl. Recently Jerfe and his
coworker: published their VII? of the aoetylmethedole (JAMA
222: h37. 1972). In this they cautioned that the more
general use of the aeotyinethndole would be fraught with some
risk. In our experience. their anticipated abuse of the
eoetylmethedole need not come ebout. end indeed~the substitution
of levomothedyl for methadone, it the patients are being
treaoed eoooraing to the latent governmental guidelines, should
decrease methadone spillage end opiate overdose deaths.
Thank you

for your consideration.
Sincerely yours.

Hex‘rink, M.D.
Professor of Psychiatry
MF/id
Eno.

�</text>
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                    <text>wvw-r-nmm

.

a;

EM

w—nv

_

July 20, 1971
Dear Mrs. Hyatt,
Thank you for your kind

offer, which I gladly accept.
the opportunity to participate in the process
of editing books, but found my time inordinately tied up
in the process. You must know that many publishers are
now actively seeking volumes on drugs of abuse, and since the
authors are for the most part inexperienced and unknown, they
send their texts to some of the better known investigators.
I

do enjoy

My

selections:

Barlow: Contemporary Brain Research in China
306—10844-5

Wulfsohn-Sances:The Nervous System and Electric Currents
306—30478—3

Kissin—Begleiter: Biology of Alcoholism
306-37111-1
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>July 9, 1971
Mrs. Carol Hyatt, Editor
Plenum Publishing Corporation
227 West 17th Street
New York, New York 10011
Dear Mrs. Hyatt:

There is a plethora of books about addiction. I have reviewed
the questions you pose and find little justification for the
special publication of these data outside the usual routes (journals).
Dr. Lal

is not

to me. Indeed, most of the participants
(except for 1, Z, 10, 11, 25, 29, 44, 55) are not known to me.
known

the ten papers cited, I am sure the data of (1) has been
published; (2) is a review from an administrative office in Washington
[Brande]; and the others are unknown. 0f the other reports, the only
one I would probably find of interest is 25 (Oswald).
Of

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt

P.S.

I seem to be answering inquiries from Plenum so frequently,
I feel like a member of your staff. Cut it out or offer me

an appointment and

retainer.

�</text>
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                    <text>:2“

v «m—m—a—v

1.1m

new.»

,

-

«in»

731:33E

30

January 1973

IBM

Box hho

Dept 261
Green
Station
Bowling
New York lOOOh
Gentlemen:

A'wr-

:—

,u.-..

wu-

Enclosed you
fOr
invoices:
as payment

will find our check in the

amount

of $828.5h

F166562

A1h5h01

——mW\

3887755
3R0191h

T127306

Please note the corrections

we

have made in your copies of

bnvoices F166562 and AthhOl. The machines are how located
Health Sciences Center at the State University of New York

at the

at Stony
the
remain
sponsoring organization,
the responsibility of
Brook, but
the International Association for Psychiatric Research. Please correct your
records for future billing.

Sincerely yours,

Max

Fink,

M.D.

Executive Director

�</text>
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              <elementText elementTextId="55173">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>7383-658

April 30. 1973

:v—vz-v

“gram-v

.

3.8.

Dawnrtasnx of

P.0.

Box 28083,

Bureau

Justice.

at narcotics

and Dnngcroun Drugs.

Central Btdiion.
Hinhington, D.C. 20005.
Gentlunnn.
Enclosed is an tpglieution for rogistruiion uﬂﬁer
uontrollud substance: act a! 1970 an cayertcr.
ﬂinae 1970 I have been project director or KIME
damn-net I38! hears-98, study of Rankin}: Ham in Grace.
During this timn wn have brought into thn United States
aanplau of hashiuh for assay (DEED P?0080527).
hsvu ulna been shipping supplies of marijuana
obtained from the HIKE to the University of
Axhcnn undnr thc study program. A shipment sent in
Deecﬂber has boon held in dugtaus in Athann. The
university of Athena has obtained a legal impart permit.
They have requested that 1% obtnin an export license,
und sitar some enquiry, I find that an arc to apply
dh nova. Enclouod is a request for ragiatratien as an
exporter. Since 1% in irrelevant to an whether this
licenae be issund to my ofriee tt 5 East 102nd Street.
9r at Stony Brook, I an bringing to ynur nttention that
I already hold In import license at 5 Butt 102nd Strect.
I! it is gullible to it'd. an export lictnse tram that
site pinata do so. If it in not. enclosed in an
and

Vb

THC

application fur registration tram this site.
Fbr your infornntion, VI hare been

fully inspected

tn; stste of New York at this location, and the
invactigtting ottiacr. Mr. John Cotsolinn, has assured us
thnﬁ Vi mach thy rogulntioaa of the stain far the management
or eautrollad subatnnces. I would b. grataful for any
dilintancc in this muttqr.

by

Sincerely yours.
w‘

.

Fink, M.D.
?rofcnsor of Psychiatry
Mb:

ml 1.1
Ens.

�</text>
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                    <text>7&amp;33-07333
28 February 1974
M

E

M

0

R A N D U H

Shreevc. M.D., Ph.D., Acting Associate Chief

To:

Walton

From:

Me: Fink. M.D.. Professor of Psychiatry

Subject:

Proposed Studies of Alcbhol Dependence

at

W.

of Staff for Research, VAH~Northport

Last

summer we were urged

st

VAH~Northport

to develop studies in alcoholism

VAR-Northport to supplement the ongoing research

the treetnent of opiate dependence. In September,
a series of studies to answer three questions:

efforts in

we

proposed

Does tolerance develop to long-acting

bencodiesepinee?

Does tolerance to e benzodiseepine pro»
vide "blockade" to alcohol (by cross-

tolerance)?

such blockade occurs, can it be put to
clinical use in the maintenance of chronic
alcohol~dependent subjects by high doses of
e longvacting bencodiecepine?

lf

we proposed to use a new benzodiszepine,
This compound is particularly promising because we
have observed a duration of action that is considerably longer
than other known beceodiezepinee. measured by clinical obeerva~
tions. EEG examinations, and blood level studies. I have ex~
teneive experience with this compound, both in the United States
and Turkey, where I have found it to be safe to use and clini-

In this project,

ORE—8063.

cally active.

-1.

�w. W.

~2-

Shreeve,ph.D.,,Ph.D.

28 February 1976

Since submitting this proposal, we have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of the
experiment. I believe we heve answered the design and safety
questions satisfactorily.

In December the Committee requested that we give them an
number; I indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971, referred to studies then approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
FDA for repeated administration of the drug in
men. These studies have not only been undertaken but have been

protocols to the

published, and include
"On

two

reports submitted to the

the Antionrioty Properties of‘a

diasspine,

268 (1973).

ORE—8083. ”

Committee:

ﬂaw Benso~

Curr. Ther. Res“

15.-

In this study, Sakslis end his

co~workers have given ORE-8063 for 21 deys from
30~l§0 mg n day.

"ass-8063, an Early Evaluation of’a New Anti—
ansisty Agent." Curr. Ther. Rsa., 1§:664 (1972).
In this study, Gallant end his co~workers re~
ported the treatment of 8 chronic alcoholic
inpatients for an average of 25 days, from 10 mg
to 160 mg daily.
In addition to these two published studies, I have submitted
copies of reports of my own work; and indicated that I am per~
sonslly aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day, in a study which I on
monitoring in Istanbul. I also attended s conference (June,
1973) st which 7 investigators (including Sskslis end Gallant)
presented date on varying dosage schedules in men for extended
periods.

I believe that the evidence already submitted is sufficient

for the Committee to determine that ORF~8063 may be given in
multiple doses-ssfely-to men. I am enclosing a copy of en
IND

submission dated

Msy

30, 1973, received by the Bureau of

�w. W.

Shrcsvo, H.D., Ph.D.

~3—

28 February 1214

Jun. 1, 1973, roflecting on a protocol which requires
the multiple—dose administration of this compound to psychiatric
patients for periods up to six wneks.

Drugs on

Committee acted unwisely in its original
data and that I acted unwisely in attempting to

I believe that the

request for

IND

demand. I further believe there is sufficient informa~
Committee for
to judge whether such a study
could be undertaken at tho VAH-Horthport.

meet

their

tion before tho

MF/cis
Encl.

it

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                    <text>January
Prof.

J. J.

Lopez

Spanish Gomittce

12 , 1966

Ihor, President

of Psychiatry
We
Paiquiatrie
Carlos
Fecultod

IV World
Ceteiir’a do

Medicine de San

Cello do Atooha

Madrid, Spain

106

DearDr. Ibor:

Itwas ametpleesumtoreviewtheamomcomntofthe
of Psychiatry, and especially the titles of
the proposed oynpooia and basic: mports. You may recall that at
the III World Congress of Psydaietry my associates md I ct‘gmized
e special 3min!!! on "BEG md Ham Psymophamcology," which
wm enthusiastically attended, md has provided a basis for
study md many reports in the intervening five years.
IV World Congress

m

cumive

and valuable oontributiom made
researchers to psyduophameoology, it is
of the neurohtmml,
the omtr'ilmtima to tho
bmes of depressive disorders, especially the cholimrgio, which
are met otrildng. The mount elebomrtiom of cholinergic mechanism
in omvulsivc therapy and the role of central enticholinergio
activity in the efficacy of mtidepresamts has led to a re—
evaluation of the dialinergic bases of psychotic depressions.
In those studies, qumtitativc eleonomoeptulogmphy. especially
teclmiques, have found moulding
the newly developed
applications.
There will be e eympooim on one aspect of this subject at
1966
meeting of the GIMP in Washington in Hatch. This symposium
the
he
will daimd by Dr. Philip Bradley of Biminghm and myself, and
will review the significance of mtidxolinergic hallucinogens for
the mdemtmding of the relation of changes in EEG and in behavior.
on clinical applications and ﬂueomtioel simii'icmoe of centml
oholimrgic mechanism for the etiology and methont
of the depmsive psychoses will not be presented. These aspects
may be of special intemst at the World Cmgmss. Peﬁmpo these
omtributims to psychiatry are not yet included in the
basic reports (Sectim IV) or sympoeia (I or V). If
of
prom
than to your esteemed attention and consideration.
would
we
not,

In reviwing the

by neurophysiologioel

thding

W

Mantel

mad

Sinoemly yours,
Pink, NJ).
Professor of Psychiatry

Hex

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                    <text>March 7, 1966

J. J. topaz Ibor, Pmident
Fourth World mamas of Psychiatry
Comma

Psiquiatrh
amama
de San Carlos

Facultw

Calla do Atoeha 106
Madrid. Spain

Dar Dr.

Ibex-t

Itmkmofywminvitewwﬁoipatimum
offioial
discussant. I mid be pleased to do 80. I
haw almaéy submitted my mnemtimn for

Woe

at tho Congress.

I do not kxm ﬁnish subjects for discussion you
hawinmind.butlmuldbeplumdtomkemtem
mtribution I can to the success of the magmas.
With

best ﬁshes for an outstmding mating.
Sincerely yours,
Max

mum

Fink. Md).

meessor of Psychiatry

�</text>
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12'.

J. J.

IV World

1966

Ibor, Moment

Games af Psychiatry

San Carla
Wm
106
Am,

Fwdtad

Calla

Lopez

I.

Madrid. Spain

M

1’1". 1330?:

I

inﬂation to discuss

Wally
W
mmmmtmiwmmsmmormmt
“New

am

pleased to accept your kind

in Psydnphamloy.“ I

pleased

am

leWmmmmmmmmemSesaim.
Iwmlimitwmrkatolsmmsasimﬂcatedinyour
I

look forward to tha

We.

Sincerely yours.

Bax Fink,

24.13.

me‘asaor of Psydﬂntzy

�</text>
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                    <text>:

lope:
It.
IV World

April 12, 1966

Ibor, Presidant

Congress of Psychiatry

Calla Mocha,

106

rum-1d 12, Spain

M

m.»

m:

Idid smdyou
abstracts as mqunated by Dr. Vallejo Najera.
thusWIWtﬂnmmbempmblam,

If the rules of the

amtdbutim as

magmas limit participatim. I beliave

official discussant and in the Roma Table
will probably be of greater intervst both to me and the audience,
than the open micatim, which I hereby withdxw.
my

My

an

best wishes for a successful (bumss.
Sincerely yours.

m; of Psychiatry
meassor
MEX

Hfzkp

Hon.

�</text>
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                    <text>December 8, 1971

T0:

135

FROM:

Max

SUBJECT:

Space at 102nd

space at

I

am

Fink,

14.1).

Street

writing to request your review of the allocation of
Street.

102nd
When

Dr. Crown joined

my

staff, it

was only possible to

office to share with Dr. Volovka because Dr. Feldstein
my
service. Since he shares an office, both he and Dr. Volovka
left
rotate their time here, with one frequently doing his work at the
Academy or at home.
assign him an

Dr. Marvin Glasser is an appointee to NH 13358. When he
worked on the 4th floor he was able to participate directly on my
work. Since August, he works in Valhalla, and is of little use to
me

or

office

my

associates.
Similarly,

—

a

when Dr. Shapiro comes

possibility only if I leave.

to

New

York he uses

my

Drs. Taylor, Abrams, Levine, and Gaztanaga are interested
in working with me. Since space at Metropolitan is not available,
and none here, we carry out our discussions by telephone - a procedure that is of little use.

I request the assignment of rooms 34, 36, 27, and 29 to
the Division, for as many months as we remain at 102nd Street and
until another resolution at 106th Street or MHMC is found.

�T0:

December 8, 1971

IBS

Personnel at 102nd Street

Professional

ReseareﬁiAssistant
R

Crown

Full

Time

Greenberg

Full

Time

Dornbush

Full

Time

Komlosi

Full

Time

Tolavka

Full

Time

Maxym

Full

Time

'h'aynor

Full

Time

Richman

Full

Time

Glasaer

3 Days

Pavel

Full

Time

Shapiro

2 Days

Garcia

Full

Time

Fink

Full

Wells

Full

Time

Abrams

1 Day

Snapper

3

Taylor

2 Days

Levine

1 Day

Time

6.8 Full Time Employees

(McNiff)

Days (FT

Evening

if

Glasser

were here)

7.6 Full Time Employees

�</text>
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                    <text>December 7, 1971

"‘0 :

IBS

FROM:

Max

SUBJECT:

Service Functions,

On

and

Fink,

M. D .

Ward 15A and OPD

basis, we admit 400 patients for observation
these, about 100 receive further treatment,
continue in our aftercare program.

an annual

detoxification.

on methadone, and

Of

The detoxification procedure follows the established
techniques of reducing dosages of methadone, requiring 7-14 days
observations. Aftercare consists of meetings with rehabilitation
counselor, social worker, and education Specialists, as well as

individual
older,

and

and group psychotherapy.

Admission

is restricted to males,

residents of

New

York City.

18

years of age and

The average a patient stays for detoxification is 9 days;
for methadone 60 days; and cyclazocine 30 days. Outpatient stays
varies for 1 month to 6 years to date.

During 1971, we regularly cared for 100-110 patients in
seen on the average 2—4 times each week. A sample month
runedown (March, 1971) is attached. In addition, we respond to
consults regarding drug abuse on 123, l3ArB, and all of metropolitan.

the

OPD,

H03pital.

,tgg14

r m.

7-.

,n.’

.4.

.Vt.,.s_..ea- .i

1‘5“»:

a».._":§$‘

ar...

7'.

¥

�TO:

188

those on

December 7, 1971
The
~

professional staff treating these patients includes
rate of $199,081. (List attached).

067, at an annual

In addition, the research staff, supported by ME 18172,
19176, 13358 and 47—072 Spend varying amounts of time in the studies
on 15A, including heroin-antagonist research, cannabis, and EEG.
On an annual basis, these sums are:
S

47—072

Personnel

2 15A

257,123

69%

13358 (41-382)

39,700

10%

18172 (41-435)

44,300

40%

19176 (41—452)

28,164

50%

(Est)

�STAFF AT 15A

-

MET ON

067

Annual

Geyer

Social Worker

$10,560

Orlin

Social Worker

11,890

Psychiatrist

14,666

Gaztanaga, P.

Psychiatrist

20,000

Jones, T.

Internist

12,600

Levine,

Psychiatrist

25,000

Maior, V.

Psychiatrist

19,250

Montese

M.

H. Worker

7,865

Resnick, R.

Psychiatrist

14,000

Clare,

G.

R.

Reuben,

J.

Psychiatrist

19,200

Taylor,

M.

Psychiatrist

25,000

Psychiatrist

18,050

Zaks, A.

TOTAL

$199,081

�</text>
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                    <text>October 25th. 1972

Editio Cantor

KG.

796 Aulendorf,

Wurtt,
W.

GEM.

Gantlunen,
The ennlaaed galley paoor is correct,
for the second proof.

and

I thank you

'

I ante that you have changed the word "doxepin" to
“ﬂaxepine” in the t1tle_und the text. In the German summary,
éoxapin is spellaé without the "e".

It is

my

ingresaion that dcxepin

is a generic

name which

in the United states is sold umﬂor thg trade name Sinequan.
My use of the word "daxepinntypo" was tn attampt to provide
reference he the generic name. I vauld 33k that you ruview
this report and make such ch:ngen in the spelling as may be
eonsiatent with ybur editorial poliay.
many

thanks,
Sincerely yours,

HI: Fink. M.D.
Exerciser of Psychiatry
MF/id

33¢.

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                    <text>October 31, 1972

Demonic G. Iozxoni, H.D.
Endo Laboratorioo, Inc.
1000 Stcvart Avunua
Gordon City, ﬂow York 11530

Dear Dr.

onooni:

Ho how. been advised by the Roooarch Conaittoo of our
school to oobnit ovidonc. that on IND has been filed. and I have
taken tho liborty of sanding than n copy of your letter. In
addition, the Connittoo not. that the toxicology data be «ado
availablo to than. In chucking my 11138, I find that I do not
have this information and I would apprecioxo your sanding me o
summary of such other information that moy bu useful to out a ooorch Counittoo.

Many

thanks.
Sincoroly yours.
Fink. M.D.
Profoosor of Psychiatry

Max

Hfzig

�</text>
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                    <text>Fabruary 13, 1966
"g’\‘

Takumi

Ikuta,

H.D,

Dcpartaont of ﬂaurapuychtatry
Kyushu Univeruity School of Madiciao
Fukuoka, Japan
Dust Dr, Ikuta:
and I arc plaaaad to reconnand your appointnunt
ItilMiatourt
the
Institutu of Psychiatry tad the Psychiatric
to
Resahrch Foundation of Missouri to Research Follav in‘
neurophysiology. foacttve April 1. 196“. at a unnthly
atlpond of $600. We leak forward to having you join our
staff and participntc in the programs in our laboratory.

Dr.

Thu Foundatiou

is also plaaned to

make

available an uuurd

of $550 to defer trtvoliag expense: from Japan to St. Louis.
This award 11 aubjcct to repayment in the event that tbs
nppotntmont is unsatisfactory within the firut at: months
of our relation-hip. 0th.: conditions are :pcllud out in
the attachsd torn, and I would bu gratcful if you ﬁbula

return a copy.

If you will indicnte when you will arrive in St. Lenin, I
will do ny bait to have aceomnodntionn available until you
can make arranxanantu for yourtelf.

My

'

best regards to Profcsaor Intanga.
join us.

ward to having you

We

are looking for~
.

Sincerely,
Pink, “.9.
Director
Max

HF/Jb

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                    <text>march 5, 1964

Takumi

Ikuta,

M.D.

Departmnnt of Neuropsychiatry

Kyushu Univornity

School of Medicine
Fukuoka , J span

Dear Dr.

Itil

Ikuta:

I look forward to having you join us the first
of April. We are pleased to enclose a check in the amount
of $550.00 to defray your traveling expenses to St. Louis.

Dr.

and

Sincerely youro,
Fink,
Director

Max

MF/Jb

Eat.

M.D.

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                    <text>January

19 , 1966

I. Ilyutdlenok
Doparunnt of
Dr. R.

Institute of

Why

Cytology andGmctios
Novosibirsk 90, Russia
Dear Dr. Ilyutchanok:

Dr. Bradley and I am pleased to omfim the invitation for
your participation in the symposium on Anticholinorgio Hollooinogono
at the forthcoming mating of the CW”, to be held in Washington, D.C. ,

onMZdeal.

Hommtﬁmtywmybemablo toattondthe

mating. Hanover, we will be pleased to consider the reading of your
report at $13 mating and its inclmion in the proposed publicatim.
of today. I have not mooivodﬁio book which you have sent
are, ImoVor, interested in your studies and I would be
very grateful if you oould send me a copy of your paper- and such
figmes as you my wish to submit. As I will probably accept the
responsibility for the reading of your paper, I would be grateful
to receive a oopy as soon as possible so that I my have the tin
As

me.

We

to ask

any questions

that

may

arise.

In the mamhilo, we are inﬁemstod in printing a'progrmn
including abstracts for distribution at the meeting md I am
requesting that you send no a title for your presentation and
a paragrwh describing it.

In the event that it would be at all possible for you to
attend this meeting, we mid be @113?th to have you join us.
Five reports will be presented during each ﬂxroo hour session,
allowing ﬂirty—five minutes for each pmsontatim and discussion.

Since the discussion may be of special interest to the participants ,
the report would be about twenty Mums in length.
The CINP has permitted us to consider the publication of this
symposiwn separately. Insofar as this subject is becaning
inminaly important, we believe that the association of the
wozk of the participants in a single volm' will be a valuable
omtnbutim. md ask your cooperation in making a manuscript
availablo at tho tint of the acting. The manuscripts should bo

approximately 20 pages of text, plus bibliography and
Hy

but

illustmtimo.

roganb.
Sinoomly yours,
Max

Pink, H.D.

Professor of Psychiatry

Hf'mp

�</text>
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                    <text>mm}; 3,
Dr. R.

1.966

I. Ilyutclnmk

Dapartmnt of

Why

Institute of Cytology and Genetics

min-ink
Russia

Dear Dr. Ilyutcmmk:

8mm Wt“:

The
for the GIN? has planed
sinultamaua translation for that portion of our
inmimymmmmmtombmmad.
just written indicating that it mid be helpful to have
copies available before tho mating ac that the translators

3mm
MM“

cmhmanopportunitytobembatterwquainmdudth

tbs manuscript.

Imldbemtefulif‘ymmldmmawpyby

aimﬂasmaaposuible.

Sincerely

yum.

m Fink.
meassor of Psychiatry
MOD.

Mrsjmh

.

�</text>
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                    <text>We!" 12, 1965
I». R. I. 11'
mparmnnt of mummies);
Inﬂux-its sf Mom and satisﬁes ,
'

Homibirsk

,

‘

‘

Russia

11mm:

Dear Br.

Prom
a maxim cm the genaral
mgr
We have derided

The 0.1.11.9.
Camittm far the fortheming meeting
on Ham-h E‘s-31, 1966 has asksd Dr. Philip Bradley

»

in Washingtm
and myself to
phugmamolggy.
3 eat
a

_

swim an thenew

to arrange. a

‘

marmm

topic

01’

~

,

_

Mﬁcholinergia hallusimgms have meshed considerable study
and the data relates t0 the pmhlams sf central
system
dwlimrgic mackmisms in the therapeutic effectshams
of wartime.
somatic treatments, and tr the special prom-m of the dissocia~
than a! ms at! behavisr.

Was and m

Famizing 5m» axpsrisnss with thasa

interest in these pmblem we would lika to invite you to
participate in this symposium

1. If yuu are able to swept this invitatim , wet-11d you
please send me a pmposed title for war pmssntation
and a
short {anagram desardbing the fame: and type of data , you wish

ts meant?

'

WWW,
Mnmupammmdadpmmbdmcingﬁmﬂm
presentations ma
Upm

mipt of these

dimsims.

Dr. Bradley and

for

m 6.1.31.3. Canines has

I

haw at least one sassim of
swimsowill
simltansom mama:
that mports may ha pmsan‘tad in
the language of mm Mae.
72. ms C.I.H.P. has m1: stated a general publisatim
policy
and we propose ta publish these reports Md dismesims as a
agreed that this

separate Velma.

his

2.

own

from

:
,

ma C.I.N.P. anticipates that

a

each

participant will

pay

«pumps in sttmding this meeting. For those attending
a sham-er flight may be organism by Dr. Philip Bradley.

am,

‘

�Dr. Ilyutd'nnok

;

~2—

’

‘

November 12, 1965

'Intheeventtimttmelfmdsmnemeew,pleaseindieete
requestedto supplmtymmeveileble fm
wt
willmmitthuemqmtstothemmmdmmive
Mittens fwﬂnirdeaieim

‘the
"

andwe

It.

MWWhmeskedmetmindioete

mbeingmdeby:

Wm

Hergmt K. Taylor
«2/0 6.1 .N. P. Semteriet
363$~16th Street. NM.

Mina

Washingtm,

no.

20010

I! you we planing to ettmd this meeting, would

dinatl‘y?

you

write to her

Dmamdleymdlladcfmemmhevingyoujoinusinthia

when.

53le 5mm,
Am Pink.

H.D.l

meeaew of Payduimy

�</text>
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                    <text>Septanblr 15. 1964

anartmant of Justin.
In-igtation and naturalization Service

U. S.

Washington, D. C.
Gentleman:

Patitiaa in hornby and. to elassify the status of alien bonn~
ticiuy' Chin Muir Romanian. now a! Grant Britain. for the
itluaneo of immigrant vita an a highly skilled pursen nacnssary
for tha technieul ptogxana now in prograas in the Misuauti
Institute of Inychittty. This petition is being ptuncnted by
the Ditnctor of the Institutn, Dr. Max Fink. and thc Dirnctor
o! thn Diviaion of thttl Diuansos of tha Stat: of Miuuouri.
Dr. Goats. A. Ulatt.
Institute at ?sychiatry is an integral part of
the Division, cruattd in Oatabor.»l962. by thn'Govarnor of the
State of Missouri. tho Hon. John F. Dalton. The Institute v.3
catatod to needy tbs problamn of tho unnttlly ill of tho Stnte
of Minnouri. to provide spatial treatmaut fscilitias for those

The Miuaouri

citixunn,

and

to gravid: ttsining

programs

for ptofcssianal

pcruonnol. aspacinily physicians in thc opacitlitod diseiplinas
of psychiatry and community psychiatry. Botauae of thn innu£~
fieitnt nunbcr of phyaicimnl available to carry cut the functions
of thn Divition of Huntal Ditcuuat, tha Govurnor and the legislature of tha Stntt of Missouri in 1961.m again in 1963. prev
vidcd fund: for this zuanatch and training cantcr.

Instituta tnployn 30 technically skilled ritearch work-rs
tnathors and ht: n clinical stuff of 90-wha_provide for the
patiant earn within thc Institute facility.
Funds to: ch: operatians at tht Institute Are proVidcd by the
Ibo
and

Lasislnturc of the Stat. of Hiaaauri, tasaarch grants from
private foundations and the National Inttitutns of Ehntnl Honlth.
and tram tpacial‘budzctnty allocatiana‘¢f the St. Louis stat:
Hospittl. For thc biennium l963~65. tho.nua total of funds dcvotcd to restarth and training within tha Instituta proper and
ch: funds allocttsd to patitnt tutu. approximated
ingludins
0 000.
$8

�U.

8.-Depaxtnant of Justice

Dr. C. H. Rosenberg
September 15. 1964

Re:

~

Inn. 5 Nat. Serv.

Page Tho

In the research prograna oi the Inatitnte. specially trained
personnel in the fields of neurophysiology. pharmacology. biocheniatry. computer sciences and experimental and clinical
psychology have been appointed. Since the majority of these
studies revolve about patients within the Institute setting,
clinical psychiatrieta are a cornntatone of these programs.
Indeed. competently trained clinical psychiatrists with epe~
cialined abilities in daacriptiva”psychietry provide much of
the basic information needed by the laboratory scientists.
For thia reason. all appointees to the clinical programs of
the lnatitnte nuat to board qualified psychiatrists. While
theta are many such in the United States, they, for the coat
part. are in clinical practice in the community and very few
are available for clinical research. For this reason. we have
sought end appointed extraordinarily qualified peychiatriete
from outside the United States to the Institute. At the
present time. 31: each qualified European and Anatralian
paychiatriats from outside the United States provide the
basic data of our clinical prograna.
One

of these paychiettiats. Dr. Karry neubaner, is leaving

early in October following hia exporiance here. It in as a
taplacenant for him that we cook the early admiasion of
Dr. Chaim Mair Rosenbctg. we have been unable to find a rm—
plncannnt from candidates within the United States. and this
important program will not be able to continue unless we can
find an immediate replacement.

It in our opinion that the oarly admission of Dr. Enacnberg
will enbatentially benefit the research and treatment programs
of the Misconri Institute of Psychiatry, and directly accrue
to the benefit of the patienta of this institution. It in our
hope that Dr.tnoaenbatg'e participation in our research pro~
grane will assist on in making conttibutiona to the nndaratand~

ing of the problems at the mentally 111. Since our programs
are anpported by national as woll as local resources. all the
information obtained in our programs ia presented as rapidly as
poaaible to the acientiiic community, thereby benefitting the
general cultural and medical welfare of the American public.

is a qualified physician. and has con.
plated_hie training leading to on advanced certificate as a
qualified paycbiatriat. He has received the Diploma in Paychelogical Medicine awarded by the Conjoint Examining Board in
England. In addition. he holds e certificate from the Education~
al Council for toroign Medical Graduates. which is a confirmation
of his general medical qualifications.

Dr. Ghabn'ueir Rosenberg

�U.

3. Dapartaanu of Justice

Dr. C. M. Bonanbarg
Saptaubar 15. 196A

Ba:

~ law. a

Hat. Sarv.

Paga‘rhraa

Hia racorda hava baau axaninad by the appropriaca committaaa
as an
at thia Instituta. and he ia qualifiad for an appointmantannual
an
carriaa
Thia
poaition
naaaareh
Scientist.
Aaaiatan:
aalary of 815.000. The position is available as of October 15,
Encloaad ara

cations:

certificataa ralatin: to Dr. Rosenbarg’a qualifi~
anﬂ Baehaiot

(1)

hasten: of Baehalor of Madicina

(2)

Full Rasiatratian as Radical Practitionar in
tho toraign List of the Register from the
canaral Radical Council.

of Surgery.

_

niplana of Paychologieal Mbdieina.
(6) Educational enuncil for Foraign Radical

(3)

Graduataa Examination.

u: will ba gratatul for your eooparation in the rapid procaaaing
of this application.
Sincaraly yours.
Ma: Fink, M.D.

Ditaator

Missouri Inatituta of Psychiatry

Gaoraa

A4

Director

Ulatt,

M.D.

Division of Manual Diaaaaea
State of Missouri
'

mljb
nae.

�</text>
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                    <text>November 23, 1971

David

40

New

J. Impastato,

Fifth

York,

Avenue
New

M.D.

York 10011

Dear David:
Your comments on the Q
A section for the forthcoming
issue of Seminars in Psychiatry were most helpful. We have re—
vised the sections most relevant to the suggestions, and I am
pleased to enclose a revised copy for your files.
&amp;

candor.

Again,

we

want to thank you

for your cooperation

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Ming
Enc.

and

�</text>
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                    <text>November

8, i97i

Dr. David impasfafo
46

New

Fiffthvenua
York iOOIi

Dear David,
i am
enclosing a draff of +he Q &amp; A sacfion of 1he
forihcoming Special issue on ECT of Shminara in Payahiatry, which is due
i0 appear in February. We have summarized the various answers and are
presanfing this digesf with some odiforiaiizing. Any suggesiions will

be appreciafad.

opinions.

Many

My

Thanks for your promo? cooperation and

franl

has? regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

�</text>
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                    <text>April 1,

Karucoyo Inenege.

a.

1965

D.

Aeeocierc Professor
Deparcaonr of ﬁeuropcychietry

Kuruno University Hospital

Roxane. Japan

Beer Dr. Inenege:
Dr. Akita Yukiceko of Fukuoka hes requested an appoint—
this Department as a Research Follov. We hove reviewed

ment in

his curriculum vitae wirh'intoreet, end ere writing to obtain
further information regerding his professional experience and

abilities.

in thie-Department ere primarily of a clinical
neurophysiologicel nature. ﬂowever, we ere now in the proceeof develoying tunnel noorophyeiologicel research laboratories,
with specific euphoria on the effects of paychotropic compound:
on brain function in dogs and other small noimnie.
The progreme

particularly interested in any comments you
regarding Er. Yukitake’e ability to carry
our independent research in clinical or experimental neurophysiology; his ability to participate in collaborative
research programs; and specifically. his technical ability
in neurophysiologicel research with dog: or cats. He are
perticulerly interested in the problem of implanted electrodes
We

would

would be

like to

make

in chronic preparations.

'

'

would be particularly indebted for specific comments
regerding Dr. Yukiteko‘s ability in maintaining cogent conversations in English and his ability to communicate with his
We

associates

and

assistants.

Thank you very much

for your

comments.

Sincerely youre5

c

Mszp

Mon

Fink. u. D.
Profesaor of Psychiatry

�</text>
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Indian 8min Associatim
Dopartnmt of Applied Chemistry
University Collage of Science and Technolow

Calcutta

Gantlm:
I have mad with intemst the establisment of than
Indian 8min Amociatim. (h behalf of my associates at
this Institute we wish to extend our best wishes for your
success. May we ask that copies of Brain News be sent to
us formadingbymambem

ofthis at

.

Sincerely yours ,
Fink, H.D.
Professor of Psychiatry

Hax

Wzkp

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                    <text>61W

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for Federal Scimtific

and Tedmical Information
5285 Port Royal Md

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desire to obtain the following mutants:
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Mew of Biomdioal Effects of
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AD

m

3&amp;2332:

A

W

and 2233

Dec. 1977)

report
(U)

on EA M76

ask for a list of other wailable
(the 1 2~dimathylwﬁeptyl analog of
temhydrocmmahiml)?
In addition
on EA

11076

may we

waxk you.
Sincerely yours ,
Mm:

Fink, RD.

Professor of Psychiatry

34.th

�</text>
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February 6th , 1973

Rational Clearinghouse for Drug Abuse Intonation,
5600

rishera

Lmna.

Roamne. Miami

208,52.

Gentlemen,

;

mid

I
appreeiate m‘bscripﬁm to the Drug
Abuse Current Ami-mus System. I had received one
or two issues last fall art. my former «dress and I
writing to ask
inscribed:

am

tint :3 want

address be

Fink, NJ).
Health Sciences; Center. Paychiatry Dept. ,
state University of Hm York at Mortar Brook,
Max

‘

Stony Brook, ant. 11790.

Sincerely you” ,

Fink, 14.1).
Professor of Psychiatry
Mu:

LIV/1U

�</text>
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                    <text>July 9.
Dr. Joan.

1973

Villiona

Dopnrtaant of Political Satanic
BUN! ot Stony Brook
Door Dr.

Williams.

wo undorstond that the Department
ho: a sorter. which
in ovnildblo for the use or other Deportnonta
from tins to tins. Vb
occasionally need the latter for 1~2 hour: to rogrouy data from
ongoing otudioo.

Mr. Ira Snaipor is responsible for the work
under
my’dirootion, and I would be grateful {Or any nouiutonoo
or
potato-ion
you may he able to give him. Should it to possible to make
a key available
for his use, V. will oooopt tho rooponnibtlity.
Mhny

thonka.
Sincerely yours.
“jZé;Lk{;2;&amp;dL

Fink. M.D.
Professor of Psychiatry
Mo:

�</text>
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                  <elementText elementTextId="101356">
                    <text>Hitch 16,

1964

Information affine:
Rational Inntitutos of Ecnlth
Bethesda, Maryland
Dear

Sir:

I would be grateful for a capy of the recent publication of
ch. Public ﬂatlth Sorvlae entlclcd ”Bibliogrtphy of World
Literature on Hantnl natardation”u.~l should like to make
this uvnilahla to the library of the Mistouti Inotltute of
P5ychlncry.

Thank you

for your cooycration.
Sincerely yours,
HI! Fink.
Director

Hrljb

NOD.

�</text>
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                    <text>H,

..

u

Wyn-Kw.‘

July 17, 1970
Mr. John

Director,

Ingersoll
BNDD

Department of Justice
Washington, D.C.
Dear Mr.

Ingersoll,

For more than four years, we have been using
diecetylmorphine (heroin) in our studies of the role of narcotic
antagonists in the treatment of opiate dependence. Because of
existing regulations, we have received our supplies from the
Department of Justice on an informal bases.

requested an additional 10 grams of
were assured that our request would be
recrystallized heroin.
filled. It has not been to date.
In March,

'wrrm-nwww‘"

We

supplies for study purposes is exhausted, and
I am writing to request 10 grams of recrystallized heroin for research
purposes—- purposes which are in the national health interest. This
work is supported by funds of the New York State Narcotic Addiction
Control Commission, the national Institute of Mental Health, etc.
.

“

we

Qur

Thank you.
"WW-Um"

Sincerely yours,

v
3,
"2w,

um

v

Max

mf/
av

'VEI-rv

,

Fink,

M.D.

Professor of Psychiatry

-~m&lt;~»:awwvwwrjrmrmw&lt;

�</text>
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                    <text>December 22, 1971

Mr. John E.

Director

Ingersoll

United States Department of Justice
bureau of Narcotics &amp; Dangerous Drugs
Nashington, D.C. 20537
Dear Mr.

Ingersoll:

and find

have examined our summary records of methadone use,
that our clinic has diapensed the following amounts:
We

(1971)

152.8 gr 31113
169.1
155.8
142.3

July

August
September

g

October

1

Attached is a tabuiation of the number of applicants
for treatment to our clinic during the same period.

I trust these data are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hing
Enc.

�</text>
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                    <text>October 8. l968

Inglis

Dr. James

Department of Psychology

_

Queen‘s University

Kingston. Ontario
CANADA

Dear Dr.

Inglis:

Dr. Dornbush has shared your letter of October 2. Our
study program of unilateral and bilateral convulsive therapy
is in progress. As Dr. Dornbush may have told you. we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying [CT and

be of

interest to

available.

that

you have

us to read

you may have a new way of
written a review. It would

this review, if copies are

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

HF:kp

�</text>
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                    <text>October 8, 1968

Inglis

Dr. James

Department of Psychology
Queen's University
Kingston. Ontario
CANADA

Inglis:

Dear Dr.

Dr. Dornbush has shared your letter of October 2. Our
study program of unilaterai and biiatera] convulsive therapy
is in progress. As Dr. Dornbush may have told you, we have
a wide experience with a variety of treatment methods.
Your

letter suggests that

applying
be of interest
avaiiabie._
ECT

you may have a new way of

that you have written a review. It woulo
to us to read this review, if copies are

and

-

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>July 7. l969
Dr. James Inglis
Department of Psychology
Queen's University
Kingston, Ontario

Canada

Dear Dr. Inglis:

associates add I thank you for the opportunity to read
your pro-print. “Similarities in the Side~£ffects of ECT and
Hy

Temporal Lobectomy in Man.“
Your review of

EEG

studies. indicating

an asymmetric

EEG

response to unilateral seizures, with accentuation of slow waves
the side of the application of electrodes is confirmed in
our studies as well.

on

of your argument is good. and we can find little
to criticize. Following your suggestion. we have recently attempted
to induce seizures by frontal electrode application. and must report
failures so far - the currents available are insufficient to induce
a GM seizure. But we will perservere.
The remainder

Again. our thanks

for your report.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

HF:kp

P.S.

The

report lacked the figures. and although clear without
we would be pleased to have these to supplement our

them,

reading.

�v'

;_.

awav-w u.»

rm:

7.“

*wan- r,_ ma
,

-

.

‘
4n“ V »~m.H.Vw—F.W'If":‘I—I'ﬁyva’W'V‘V‘mleﬁhwdgm‘
'
‘

»

&gt;

-

v.. q.
.

aw-.5“ . -7.r-V,V-(W,_,
«

,ww-n ~~\.Ww'_l'.ﬂ/--, wwamr‘i'wy-rﬁ,Wgrf»; wavy- vw

July 7,

1969

Dent 3111,
The

listing

from

thin laboratory nhould ha

changed

to:

wwﬂln'v'mld‘

.v—

.m-u—r

'W‘ar'r‘

w

Pink, M13, M.D.
Professor of Paychtncry

Haw York

Medical College

5 East 102 Street
New York City 10029

the tlephonc is correct.
Much

his address

it

of our data will
the same.

come

to you from Dr. Simeon. and

Sinceroly yours.

Max

Pink, M.D.

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                    <text>...,,._

v,‘

,.v-v

r—

T

“W”

w.

,..

,

.

vary-.7",-

October 26, 1970

“WW

.
,..

"1,“,

Invn'bwww—w—V’

Dr. James

Inglis

Department of Psychology
Queen's University
Kingston, Ontario
CANADA

Dear Dr.

Inglis:

”Shock. Surgery and Cerebral
I read with interest, and enthusiasm except
for your insensitivity in continuing to use the barbaric non—
descriptive term of ”shoe ”.
Thank you

for your reprint,

Asymmetry” which

My

associates

have

treated

a few

patients with multiple

induced convulsions using frontal electrode placements. While
induction is more difficult, it is practical, however, and
the results comparable to bitemporel and unilateral placements.
We are now studying the memory, clinical and EEG effects in a

systematic way.
A

preprint of our recent data is enclosed.

Again, many thanks.

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

mrzkt

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                    <text>and-W, mmmn—mu mwwv‘vw‘

-—c,

v...

.mrﬂl—gg

.7"

q...

“7. .1.

October 26, 1970
Dr. James Inglis
Department of Psychology
Queen's University
Kingston, Ontario
CANADA

Dear Dr.

Inglis:

Thank you for your reprint, "Shock, Surgery and Cerebral
Asymmetry" which I read with interest, and enthusiasm except.
for your insensitivity in continuing to use the barbaric non"

descriptive term of "shoc ".
My associates have treated a few patients with multiple
induced convulsions using frontal electrode placements. While

induction is more difficult, it is practical, however, and
the results comparable to bitemporal and unilateral placements.’
We are now studying the memory, clinical and EEG effects in a
systematic way.
A preprint of our recent data is enclosed.
Again, many thanks.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

Time-v

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                    <text>chober '9,

lngrisano
Radiation Sys+ems, inc.
McLean, Virginia

Mr. M.N.

£969

Dear Mr. ingrisano.
Thank you for *ha informa+!on on fhe fympanlc
have read wlfh infarasf. Ha are tn 5 position
uhtch
fhermomefer.
+0 underfake #hese sfudies, but bofare
submlf a firm order, wouid
fha
dwmonsfraflon
of
for
a
nifhor
equtpmenf, or an optton +0
ask,
canes! affer 15 days.
I

I

.

New

I woutd
prefer a demonstraf!on. ls fhe machine in
York or can one of your represanfafives demonstrafe !? at our

£aboraforles

?

Many

fhankg.

Sinceraiy yours,
Max

F!nk, M.D.

Professor of Psychlafry

�</text>
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                    <text>June 17, 1965

David H. Ingvar, 1-1.9.

Laboratory of Clinical Neumphysiology
Depar'tmnt of Neurology

University of
Lmd, Swedm

Lund

Dear Dr. Ingvar:
EEG analysis
request for we informtim regarding
by digital water was mfemd to ma by Mr. Shapiro. I am
pleased to enclose copies of sum earlier descriptions of this
work as well as a most meant report.
We on, at pmsent, smumizing our experiences with the
1710 system and will send you a copy as soon as it is available.

Your

Sincerely yours ,
Fink, M.D.
Professor of Psydliatry

Max

MF:kp

enclosures

'

_

�</text>
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                    <text>w.

._,,.g.,.,

‘_,,..7,,.‘...

W.

w_

W

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W,."7 u. ,m”...

q

u ... 1m... .,. n ‘1...

‘_

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. __

.\"ﬁrm”...w . ,____,

n. v mw

mmmuv

V

""

‘

"'
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"-'

:
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&gt;"

'

August

RF.

The
v;w;ww’rﬁm-ev-rw‘w

.

"

Institute for the

l2,

1969

Study of

Drug Dependence
Chandos House
2. Queen Anne Street
London. Elm 03R. England

Gentlemen:

""‘7

:‘WWF"*

“(Ira-TYg‘UpR"

We are planning a conference
on cannabis and in writing
Ciba Foundation regarding their recent guest meeting,
the
to
they directed us to you. He would appreciate a list of the
participants at the Ciba meeting on the-botany and chemistry
of cannabis and the titles of their presentations. This would
be helpful to us in planning our conference.

Sincerely yours.
Fink, ".0.
Professor of Psychiatry

Max

MF:kp

w

:‘z'y

NZWPWJ'NM‘Q’JF'W‘Wgyr"

‘

W-

a“

’

("K-a».

�</text>
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                    <text>August 12. 1969
The

Institute for the Study of

Drug Dependence
Chandos House
2. Queen Anne Street

London. Hlm 08R. England

Gentlemen:

are planning a conference on cannabis and in writing
to the Ciba Foundation regarding their recent guest meeting.
they directed us to you. He would appreciate a list of the
participants at the Ciba meeting on the botany and chemistry
of cannabis and the titles of their presentations. This would
be helpful to us in planning our conference.
We

Sincerely yours.
Fink, ".0.
Professor of Psychiatry
Max

Mszp

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                    <text>July 6,

1964

Rsscsrch Dacumsntstion Section
Division of Research Grants
Hstiansl Institutas of Hsalth
Bsthasds. Maryland 20014
Gentleman:

In chucking through the Reoaatch Grants Index for fiacsl year
1963. Vbluns I, I was interested in detcrmining whether sny
stuntssa wsra moasurins the alactrocnuaphslographic changes
induced by drugs in dogs. On page 292, the citation for dogs
(oxporimsntal) suggests that compilation can be obtained on

"qut

s

l vauld be grateful for any citationa of a study supported by
tbs Nstionsl Institutes of Health in the area of electrasnenphalogrsphy, dogs. experimnntnl, with or without the us:
of psychotropic or other drugai
Thank you very much.

Sincerely yours,
M81

Fink,

Director

241mb

Ho Do

�</text>
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                    <text>rel—u".

”ﬂu—Mn

”mervunm—uwu

.v‘...

.w—

July 23,

1964

Rooootoh DooumonCotton Seotiao
Division of Roscoroh Grunts‘ ‘.
national Instituzol of Health

Botheuda, Morylond

20014V

Gontlunmn:
The Plychiotrlc Enqoorch Foundation of Missouri has a
number of Rottontl Institutes of Hodlth grantees, only
one of which ha: roeoiﬂod sleepy of tho Roloaxoh Grants
Inna: for 1963. The Foundation officers would-vary

much

avptnetato onothor copy, if'thaoo are available a?

to: distribution.

Sincerlly yours,
ﬂax Fink,

Director
HF/jb

M.

9.

�</text>
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.

n.

w

v

.v

W..." In".- xvi: «ma-w woman-W...“

September- 20, 1965

Internal Remus Service
1114 Markot Street

St. lads, Hissmmi
Gentlemen:

Emlomd am

famolaim formfund of

£1th

emlyoollectodmdpaiddm‘ingmlasttwo
two
of 1965 by
of 19614 .md the
first
quarters
quarters
the Psychiatric Rosoamh Pomdatim (u3—0‘7BSBBB). I

mdwemhemby
rmttmfmmutisfactory,
of $1394.81.
mutating mfmd in the

mt

Sinoemly yours ,

Max

ijm

Pink,

M.D.

Executive Director

,,

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i

June 14, 1971

i

Internal

Andover,

Revenue Service Center

Massachusetts 01812
Gentlemen:

Enclosed is our check for $184.90 which represents the
Federal Withholding Tex payment for the month of May 1970. We
are unable to deposit this in the usual manner since our
cards, which we have repeatedly requested, have not been sent
to us.

is

Fleece deposit to our account. Our identification number

11-215 7913.

Sincerely yours,
Fink, M.D.
Executive Director

Max

Mr:kt

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                    <text>Mr
S D

I

International Business

mm:
Hidden
micaao, Illinois

618 South

31, 1953

mm
A

Avenue
60605

Attention: John Punter

(autumn:

frm the

In the last

IBM ~ SDI

raw days, I have received three abstracts
and am very pleased to participate in this

program. I am returning two cards with the. mquast that
address be manger}, and with the additimal request that
m‘ip'tors by added

10W)!

(BBQ),

for

my

my
das—

interest including ehctmenmpha»

Infomtim Ihtﬁeval,

SDI.

As Mr. Dmkoehler may have told yw, I am internsted
in doveloping an infomation retrieval system for 13831decolow. In this endeavor I have enlisted his aid and have moantly mama the developmnt of abstracts for am of our
reprints as a start in developing this system.
I would appmciata any IBM publications related to SDI.
Also, if there is available a description of the present project,
my be helpful in our discussion with various fimncial bodies
in our effort to underwrite our experiments.

m

Mymvexymdz fwinaludingminthis prom.
Sincerely yours ,
Pink,
m
Dimator

M.

D.

�</text>
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                    <text>«'1

«q.

”pm”,

rw‘,

»

"w—v.‘F——VW&lt;

‘TF~"'“lw'rle-nw

7383v78383
WWW!

26 Hovunber 1973

Convutar Dcsign Corporation
12401 Olynpic Boulavntd
Lou basal... Calitornta 9006‘
Gunnlcnan:

I unuld npproeiutn a danctipeion
Statistician. which I

Conpncorp Micro

rcccnt ilauc of Sciuan.

nnd 921cc 11.:
saw advort£a¢d

for eh:
in a

Thank you.

Sinccrcly yearn.
Fink. B.D.
Ptofcscor of Payahiatry

Max

311:1:

�</text>
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                    <text>Scptcmbor 11, 1964

International Inn
Circle
14th and M Stratus,

Thomms

N. W.

Washington‘s. D. C.
Atccnnion:

Rnsnrvations Clerk

Guntlcnou:

Please :nscrvu a singla room for tho night: of Octobar
and 2b. 196‘

in

my

aunt.

Your unrly confirmation of abovu rnsorvation
much

will be vary

upproeiatod.

Sincerely yours.
Ma: Fink. M. D.

Diroetor

Iii/5b

23

�</text>
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                    <text>October 19,

International Inn
Circle, lath and

Thomas

Washington 5 , D.C.

M.

Streets

1961+

, N.W.

Dear Sim:

Please change

earlier reservations. I
I

my

am

arriving instead

on Thursday, October 22nd (approximtely 8—9 p.m.) and will
need a twin bed room accmmdation. We will
depart on
Sunday, October 25th.

still

Enclosed find check

for late arrival.
Sincerely yours,
Max

Fink,

Director

Inf/ls

M.D.

�</text>
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                    <text>Dem 1‘5, 196“

The

Inn
Intmtimal
13th 8 H.

Thomas

Cinch,

Washingtm 5, D.C.

Attention:

Struts,

NM.

Wwaﬂms Hanger

60mm:

Wywplmmmmamghmmfwmeevening

omeuary luthandISt’n.

inmmofjr

{329.14ch

DnTumnItil

Please mnfim.
Emlomd

is a deposit of

“made you

$30.00. 1:0

mm both msewatims.

for your cooperatim;
I

SW13!

yours,

Mu Pink,

14.1).

Director

mfmk

P.S. This

Mica

:13

for the

AC)?

mating.

�</text>
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                    <text>September 29, 1970
Chairman

Internship Selection Committee

Dear

Sir:

to me as a Summer Research
Trainee in 1968. He participated in our study program of EEG
changes with psychoactive drugs in normal volunteers. He became
Mr. Alan D. Morris was known

acquainted with the normal human electroencephalogram and developed
an appreciation for the subtle changes accompanying threshold

drug dosages.

an intelligent, cooperative and friendly young man.
grﬂat efforts to accomplish his assign-ants. He exhibited
an enthusiasm for pharmacology and I very much enjoyed discussing

He
He made

is

his ideas.

Since his freshman year, I have occasionally met him at
meetings in the College. He continues to exhibit an enthusiasm
in medicine and I would recommend him highly for continued

training.

Sincerely yours,
Fink, M.D.
Professor of PsyChiatry

Max

MFtkt

�</text>
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                    <text>Pam-y 10,

1966

War
Max Am
York,
355

New

NW York

Gonﬂmm

ImpInninga Mpmmmmmimﬂmiaamr. I
dummlymatmn
njmwofnytiuinm.umixw
undid». Whlmmtmﬂutmmyismmodtotm
official Soviet may, I would be warm for any informatim

mtymmymmihmmgamingspaddtmorpmm
Mmbanvdhbhdmdngthiasmr.
81:2me yams,
Max

Fink, H.D.

Professor of Psychiatry

Wzkp

�</text>
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                    <text>Septuber 20,

1963

'

Wisconsin Avenu: 8 Bradley Blvd.
Bethesda 1n,

Ganthmm

mm

Osmium mtingm
Iplmtoatmndﬂwwrﬁml
1963.
and October
Saptexsber 30.

1,

Please reserve a single man for

me

for the night of

and themfm,
I will arr-1w on Septanﬁaar 29, at 9:08pm..$10.00.
amlose my «posit meal: in the mount of
Sinai-ml):

F

$0

Wm

H.
m
M;
Dimctw

Do.

�</text>
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                    <text>,.—VV_,.

...

January 24, 1972
Charles

Inturrisi,

Ph.D.

Cornell University Eedical College

New

York City

Dear Dr.

Inturrisi,
Enclosed

is

a sample of

MK—790,

which you requested.

We are not, at present, planning intensive studies of methadone.
Nevertheless, I have sent your letter and reprint to Robert Levine, M.D.
of my staff, for his consideration. Should he or his associates wish
to establish a study, he will contact you. It will be necessary for
a protocol to be written and approved by the appropriate commitees of
this medical school, and I presume of your ownv- but those details can
wait on some common interest.

for the assay of MK~790, then
in
interested
correlating the blood levels of
definitely
thsi compound with the clinical course of our subjects. I wish you

we

would be

Should you develop methods

success, and should you achieve the result, olease call

me.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

cc: Robert Levine, M.D.

�</text>
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                    <text>i1
”WWWTWTW’E

July

28‘,

1967

Dr. Pedro J. Irigaray
John [Instead Hospital
Burner, North Carolina 27509
Dear Dr. Irigaray:

It was a pleasure to speak to you last week regarding a
study of cyclazooine in the treatment failurgas in your present
collaborative dopmssion study. While we had intended to
arrange a meeting within the next few weeks , the mious
vacation sawdules precluded such a mating.
Since the schedules for early September am not yet
we have decided to defer suoh a mating and I look
forward to calling; you again sow-after Labor Day.

Wed,
I

1061-:

forward

to

mooning you.

Sincerely yours ,
Fink, MD.
Professor of Psychiatry

Max

�</text>
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                    <text>J1me 23, 1965

Hr. Donald G. Irvine
Research Biochemist
The Saskatchewan Hospital
North Battleford, Carmda
Dear Mr. Irvine:
Thank you very nuoh for your letter of June 21. It would
indeed be possible for you to visit these laboratories , but
the period you suggest in mid—August is a tine when both Dr. Itil
md I plan to be away. We would be pleased to have you visit
these laboratories before the end of July since we plan to leave
about the third of August or again after the tenth of September,
men we will have mtumed from some meetings.
EEG

Your statement that you are interested in the genetics of
patterns is an interesting one. I wonder if you would tell

mmmmehoutwmtyouhavebeendoingandifyouhaveany

reports omoeming your work, both Dr.
pleased to read them.

Itil and I mid be

Sincerely yours ,
way-h

«4"W'ie‘.

Fink, M.D.
Professor of Psychiatry

Max

Mfzkp

�</text>
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                    <text>November I, 1983
Mr. Peter Irwin
1m Hirsholm #6
11125 Riehen

Switzerland
Dear Peter,

Thank you for your letter of October 19. Receipt of the enclosed
reprint request stimulates me to answer today, and to bring you up to date with
happenings in New York.
Vojta called to invite me for dinner at his home, and then told me
that his large grant to study EEG's in prisoners was hung up in a political argument

whether biological studies of criminality were warranted since 'everyone knows
is socially determined'. When he called me initially about computer
I
him to use our system if he wished. I gave him the same caveat,
encouraged
use,
that IBM may stop support when we may need it most. (I did not demur as to its use
long as it is functioning, I am pleased to have it used, with charges consistent
-so
with the real expenses, usually nominal.) He told me that he had this large grant
and I suggested that, if the funds were available, he might wish to get the type of
system that you, John Pavel, and Don had recommended to me. By writing his own
programs, he should be able to get the outputs that would optimize any findings.

-—

that criminality

Your comments about the Neurometrics machine are consistent with
it, and I did not recommend that course of action.

my own image of

‘

t
’

WWW"

7
"M

.i

,1

-

.

.

w;-

v

[Mr

Y-‘r

1m”:

v-rrlwWJPWnruW

We are in the midst of a pharmaco—EEG study of a putative betablocker,
azepexole, and continuing our clinical explorations, recording
adrenergic
EEG's in patients during ECT, lithium, lithium plus haloperidol, lithium plus
carbamazepine, and propranolol therapies. So far, we are seeing 'neurotoxic'
effects with ECT and with lithium plus haloperidol, and these should prove
interesting when quantified.
We finally received approval for a nursing position within the
offered
it to Lynn Johnson, only to be rejected as she said that she
Department,
had a better paying job. I am very disappointed, since [could have hired a nurse in
April, at the same time as I put Linda and Emily on Research Foundation moneys.
In trying to work within the State system to assure her retirement funds, we have
lost more than six months in our clinical studies.

�Peter Irwin

November 1, 1983

Page 2

l expect Gabrielle to visit us next week for a few days. She is 93
route to her company offices-in New Jersey. The week after, Werner Herrmann is
visiting, and I look forward to a few days of pharmaco—EEG talk. Sure will miss
your pithy comments.

Congratulations on your membership in IPEG. I received a copy of
the 'official' membership list, and you are now an active member -- if I read the
German correctly. (Walter Sannita has written to me, asking whether I would
intercede on his behalf, for membership. Perhaps we will both have to write letters
for him.) I have heard nothing about a replacement for Dieter Bente, either in his
Universityy or in IPEG, but expect that I will know more after Werner visits.
My children are well. Jon is now busy visiting volcanoes in Oregon,
Hawaii, and lsrael. He has received an NSF grant to contrast findings in four
locations and he is enjoying doing the project.
i received another package of tulip bulbs from Holland, spent this
week-end
past
getting them into the ground. Lots of work -— and are my muscles
stiff today but well worth it in the Spring, if the results are as brilliant as we
had this past year.

-

My best to Barbara and the children.

Sincerely yours,

�</text>
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                    <text>I1
mm.--.-..m-w1

March 9, 1985
Mr. Peter Irwin
Medical Research Department
Sandoz Inc.
Hanover, New Jersey
Dear Peter,
I read the article by Glassman
st 31. and react much as you did. There is
as much evidence that drowsiness was the active component in the effects on
craving as that a specific biochemical process was responsible. But it seems
difficult to attack the conclusions based on these data alone. I seem to recall that
our subjects, given clonidine, also had a significant degree of drowsiness, as did our
subjects when given higher doses of diazepam and bromazepam. Also, the time
course of our experience would be applicable.

In order to do justice to a critique of this report, I think we would have to

extract some of our own data, see if they are relevant, and make a more

compelling case than your argument. The dependence on the PDR does not have
much cachet; indeed, it is not considered a relable source of scientific information,
being seen as a negotiated average of sentiments between legal partisans from
industry and less-than-competent administrative bureaucrats. Such an argument
may have place in the board-rooms of industry or the law courts, but hardly in
SCIENCE.
am so busy with convulsive therapy, that Glassman's peccadillos and the
pseudo-science of SCIENCE influence me little.
I

The historical paper which I wrote for IPEG in memory of Bente has been
published. I enclose a copy for your bulletin-board.
The IBM 1800 is acting up again, and i am getting desparate to end it all,
either by decapitating the machine and chucking all the work, or by replacing it
with the H21 IBM-AT based system. I am visiting HZI next week to see if there is
some fire where there has been nil-smoke for so long.
Meanwhile, Itil has convinced Hoffmann-La Roche that he can distinguish
three
formulations of Valium; they have petitioned the FDA to change the
among

rules on generics and look-alikes by requiring pharmacodynamic equivalence as well
as pharmacokinetic and chemical dissolution equivalence. The petition went in two
weeks ago; you can read all about it in the pink sheets. if the FDA is convinced and
changes the regulations, industry will need our pharmaco-EEG studies as much as
they needed the sleep-EEG studies when the FDA accepted such studies as
evidence of soporific activity. If the FDA acts favorably, I will get my new AT
system; and you could go into business for yourself with little investment.
Keep the faith. My best regards.
Sincerely yours,
“it

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                    <text>December 29, l967
Mr. Peter M. Irwin
315 w. 70th Street, #GJ
New York, New York l0023

Dear Hr. Irwin:
I am pleased to indicate that the erartment of Psychiatry
will extend an appointment as research assistant, effective
January l5, l968. In this program you will be responsible for
your assignments to me. The principal program in which you will
be working is in the evaluation of the treatment of narcotic
addicts, a program supported both by the USPHS and the New York
State Narcotic Commission. You will be asked to work 40 hours
per week and to assist in the data collection and data analysis
of this progrmn.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>April 17 , 1967

2w

“Luv—u

—_,;wl,«-

«-

Dr. Samel Irwin
Department of Psychiatry
University of Oregon School of Medicine

Portlm,

Oregon

-¢-wmw7‘m‘l~

Dear Sam,
”a

J—I-wHH—"‘C’

A

.4

Itwasapleasmetoueetwithymlsstweek. Ididmt

of your interest in mootics and narcotic antagonists
and it was most impressive to hear you speak of these substances
know

with an adrnimble
Enclosed

-....

.u—aw—

My

w

facility.

is our recent report

on

LSD.

best regards.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Mchp

�</text>
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                    <text>July l8,

1968

Dr. Samuel Irwin
Professor of Pharmacology

Department of Psychiatry
University of Oregon Medical School
3l8l s.w. Sam Jackson Park Road
Portland. Oregon 97201
Dear Sam.
Your nephew has been working with me for more than onehtlf year and I want to thank you for sending him. He has
learned rapidly and is an asset to our program.
I plan

to be in Portland forea drug problem

session on August l4~15.

I

will probably arrive

and would welcome an opportunity to meet with you
evening of the l3th or on the l5th.
I may

bring Peter to keep

him

summer school

on the

either the

out of mischief.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

l3th

�</text>
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                    <text>t

November 20, 1967

Dr. Harris

University of Kentucky
Lexington, Kentucky

Dear Dr.
We

g

E‘

i

i

Isbeii

Department of Psychiatry

Isbeii:
are interested in undertaking studies of tetrahydro»

cannabinoi and have been told by

own IND.

At

their suggestion,

NIMH

that

we

must

file

our

writing to ask your
permission to refer to the ﬁharmacoiogic data in your IND

when we

file

our own.

Thank you

May I

I am

have your permission?

for your cooperation.
Sincereiy yours,
Max

Fink,

M.D.

Professor of Psycniatry

Hszp

�</text>
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        <name>Correspondence</name>
      </tag>
    </tagContainer>
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</itemContainer>
