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                    <text>September 18, 1979
Mrs. K. Hildreth

Dept.

OB/GYN

630 West 168 Street
York City

New

Dear Mrs.

Hildreth,

u have received the invitation to continue participation
in the Neuroendocrine Journal Club, and have been asked to monitor two

journals, Brain

and Experimental Neurology.

I regret to say that I shall be moving my home to the
University, and it will be unlikely that I will be able to continue to
attend the meetings of the Club, or to participate further.
Please thank Drs. Ferin and Krieger for thinking of
Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

me.

�</text>
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                    <text>January 10, 1964

Professor Denis Hill

Academic Dcpcrtmnt of Psychiatry

Middlcsox Hospital Medical Sotml
Middlcscx Hespital
Inndon, w. 1, ugh—1nd
Dear Professor Hill:

I.

Pierce Jams of the Royal Perth Hospital in Western
applied for an appointmnt at this Institute, and has
mfcmd us to you for additimal infmtim. This Institute is tho
and training camber of the Division of Humanism of
the State of Hisamri. Laboratories in eleotxmnccﬁwiommy, neuro—
physiology, plumacolow. and olirdcal paydmlow ham already been
established. In addiﬁm, we are mapmsiblc for a psychiatric
residency training pmgmm which now has 17 candidates enrolled.

Australia

Dr.

hem

room

mom on two positions available at the Institute which may
interest to Dr. Jam. One position carries the mpmsibility
for the psychiatric residency training
in cmjmotim with
clinical macro-u. Mother may be thatpoem
of a senior investigator respcnsible for a section of clinical Inseam.
be of

&lt;

grateful for your opinim regarding Dr. Jms'
training
moral: emotions». his abilities as a teachw. and
any sumticnc you my have regarding his ability for independent
clinical research. Itwmldalaobe Mlpmlifwemuldobtainsom
information regarding his masons for leaving Amtrak.
Tmmk you very much for your cooperation.

I

would be

and

Sincerely yours,Max

Fink,

Director

H. D.

�</text>
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                    <text>September 11, 1984
Jonathan A. Hill, Bookseller

470 West End Avenue
New York, N.Y. 10024

Dear Mr. Hill
I

have read your advertisement in a recent issue of JAMA. I am interested

in obtaining copies of the following psychiatric books, and would appreciate your

quotation.

Meduna, Ladislaus von. Die Konvulsionstherapie der Schizophrenic. Carl Marhoid
Verlagsbuchhandlung, Halle a. 5., 1937, 121 pp.

Wagner-Jauregg, Julius. Fieber- und lniektionstherapie. Ausgewﬂhlte Beitrage
1887-4935. Verlag ﬂir Medizin, Weidmann 6: Co., Wien, Leipzig, Bern. 1936,
299 pp.

Wagner-Jauregg, Julius. Lebenserinnerungen. Herausgegeben und erganzt von L.
Schdnbauer und M. Jantsch. Springer-Verlag, Wien, 1950, 187 pp.
Sakel, M. Neue Behandlungsmethode der Schizophrenie. Perles, Wien, 1935.
If there are questions, I can be reached
Hospital, (516) Milt-2929, most afternoons.

at my office at University

Thank you for your assistance.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

m-rww

r
&lt;

p
,.

.
..-

Parr-«m

Wpy

.m-Wamv‘ﬂm

£4

W“

�</text>
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                    <text>Hitch a.’

The Honorsble Senator
United Stetes Seoste

1955

Lister 8111

Rethington. n.c,
Deer Seoetor

Hill:

I en'writin; to recommend your support of 3111 8.597, to «amend
the Public Health Survico Act to provide sdditionel funds for nodicel
librsry services

end

facilities.

.

During tho pest 2 1/2 years, with the support of Governor John
Delton, end now, Governor Horton Heetnes, the Division of Huntsl
Disesses of the Stste of Missouri has established s reoesrch sad
treininz center in St. Louis. This center is dediceted to studying
_the problems of the eevore mantelly ill, end in the training of
psychietrists for public service. Va here been sble to dovelop our

facilities with the support of the legislature of Hisaouri. the

public through their direct contributions. end the Public Health
Service which hes cede eveileble to no funds under the Beelth
lecilitiee Act for the cohplstioo of our lsboretory.
During this growth potion. we have not been eble to obtain
the foods necessery to estsblish library fscilitiee sdequete to
the needs of our scientists. While at here usde s pilot effort
to provide so iniotletion rottievsl systeu in our computer center,
to enlerge our librsry so that it now has 5,000 volumes. to expand
our journel subscription lists to thet we note evsilsble to our
scientists end students 180 jourusls in psychiatry. the services
ere still insdequete.
There is greet coed for tho expansion of library £scilitiee,
both st this center end in the othor oedicsl centers in the oidwcst.
we ere sotsbliohing a documentation contsr for the behaviorsl sciences.
end this conter will seek support not only from the logislsture of
Missouri. but es it will be a tlsionel feoility. from the rederel
Government as woll.

�2.

’

leellalng the needs for teeeerch 1n the heelth disciplines.
the Congress during the pest two decades be: expended funds for
teeeerch end training ea that many worthwhile programs here been launched
end ere now producing dete end tteinlng pertonnel so that the heelth
care of the Anerlcan public 1e enong the beat in the world. However.
each specialized fecilltlee es librerlee have not received the support
they need. Senate 3111 5.597 will do much to correct this need. My
eseoeletee in these laboratories join me in commending your tevoteble
review of this bill.
Sincerely yours.

Hrs]:

Me: Pink. M.D.
Heed, Dlvlelon of Research

,

Profeeeot of Peythletty

�</text>
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                    <text>r“..-

,

WWW—.mm. mx—m
.

3«7

1"!“an

WW.»-

.7
vi

t.

T.

October 18 , 1962

r—w

.-

~r..-u.,—-v“w,..,.uvv.-

r—ruwv-v

n-u—v

”Wuwupm-qu

YTW.

I:
~

~wnwm~vwwr~

4,.

.
,w.

"w.

.,...v..r

Staff

Departmnt of Marinate]. Paychiatry
Hillside Hospital
P. O. Box

61911

38-

Oaks, New York

Dear Friends:
Three days ago I received a package from Hillside
and was both surprised 3nd pleased with the selection Hospital
of gifts.
I have put both the desk sat and the
to uoc and

believe that both are most approprictcdictionary
to my present needs.
I regret that in the hectic days of Mich-September I
was unable to be with you for the formal presentation.
I would have enamel being there, and hope that m can
get together sum time anon.

Accepting your good thoughts, I am taking the liberty
copy of the announcemnt or the new Institute,
knowing that in this you will see the potential
fulfillmnt
of com of our
and upirationc.

of enclosing a

mm

My

best regards,
Sincerely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

HF

HI: Fink,
Director

nu

M. D.

0m-

Addrcsa correspondence to

:

Shoo Arsenal

Street, St. Louis 39,

Mo.

,

/

�</text>
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                    <text>Nevember 20. 1967

“aw

Dr. Donald F. Kle1n

n1rector cf Research

V811iside Hosp1ta1
G1en Oaks. New York

08!? 90“.“
In requnse to your request. enc1osed 1s a 11st of‘my
pub11cat1ans. All the pub11cat1ons between 1955 and 1963
resulted {ram wcrk at H11131de Hospital In add1t1on there
‘are citat1ons 15 1953. 1964. 1965 and 1966 wh1ch are marked
1n the 11st. uh1ch are predom1naat1y the resuit of work done

at

aini
q-

W;

H111s1da Hosp1ta1

*5

1*

.

Sincere1y your3.

V5-

V

3
11“;
_

"a

3‘15."

; 3!§?'&lt;tf

7

Professar of Psychiatry

_..
,gM_~
4M—

1’"

.

«3

‘

b y
NWmM
.9

3"
2;”.‘1‘;'

'

MF:kp

“

1.139%

.,1,'

1
"91.9%,..‘45;

:2lHﬁﬂﬁ

r,
-

7.1

.(
V‘s“ W»;—
V

m
I

j

(H

,9“.
«4

ﬂq-K'm-

1*.1' his"

.«9'9-5?
..‘.“

11-J-

.

:ﬁr,

�</text>
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                    <text>7353~6h3
A13141

Mr. Jonathan
Box 8&amp;3,

2?. 1973

Fink,

Rabat. Union,

Colby College,
Httarville, Mhina oh901.

Dm Jon.
(lain;

Maw months ago

some

studies of

of ”1.1mm.

M.

are enclosed. and

TM

Peter
as u

Crown was

interested in

emu-1m to the effects

tint time he wrote up the not» which
“muted the weanpanying papers.

A: man knew, I am not enthusiastic about
encouraging you in m. but if yon are reading the
perhaps mien notes would be of me help.

51m erely ,

uflid

he.

literature.

�</text>
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                    <text>a“...

.—

m—w‘.‘

-

-wm“

—.

«nu-m”!

W"

W“

'March 25, 1970

-

San Francisco Hilton

Mason and

O'Farrell
California

San Francisco,

94109

Actuation: Raservation Manager
Dear

Sir:

With regard to my reservation for May 7. I will be arriving
on American Airlines Flight 15 which is scheduled to be in
San Francisco at 10:00 p.m. Please change checkain timc to 11:00 p.m.

Sincerely yours,
Max

Fink , Md}.

Professor of Psychiatry

�</text>
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                    <text>Mr

12 , 1965

Dr. Harold Hindu!)
Salaam State Research Hospital

(Balsam, Illinois

um Hamid:
Cmittce for the forthwnin‘g mating
Prom28-491,
m C.I.N.P. Hm
1966 has asked Dr. Fhilip Bradley
and myself to
a «mimics: the moral topic of new
Wehmdecidadtomgeasymposimmthe
in

m

Washington: on

phagmlggy.
sub cat 0 :

WWO

W.

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md the data ﬂutes to the problem of mm}. mums system
in the ﬁxmpeutic effects of various
manner-git:
somatic mummm , and to the special mm: of the dissed»
121011

of

mm”

EEG

and behwior.

mdyour
mm
intamtinﬂmcpmblmmwmldliketoinvitoyouto

Remixingméxpaﬂmmwithm

partiaipnto in this
1.

If you an

pleas: Md m

swim.

abln to

a proposed

mp1: this invitation,

shortpamgraph doseribingtm

ta pmmt?

would you
and a

title for your presentation,

'

few and type

of dota-youwiah
'

mad I
for
willmhaupammdodpmgmbalmcingtmtim
has
presentations md discussions. The C.I.N.P.
a!
haw
one
least
will
symposim
swim
at
that this
mad
be
may
pmsmted in
simltmous translation so that reports

Upon

receipt of these admwledmts, Dr. Bradley

WWMW hm
2. “an C.I.H.P.

m“

not stand a

W

moral publicatim

policy

andmpmpoaotepublishtrnmrnm mddiscmsimsaa a
separate:

voltm.

mo C.I.N.P. mticipams that nah participmt will pay
his om expanses in “taming this meeting. For thosa attending
flight my be organimd by Dr. Philip Bradley.
a
km
3.

W, Mr

�31mm

Dr.

-2-

Homer 12,

4

1965

plum indicate
Inﬂuevmtmtmlﬂndsmmam,
requested to aupplmt your-availabls funds and we

mt
ﬁnuwmitmmmmmmgmmd‘miw
(luminous for that" mien.
tho

-h. memdtmtxu-askodﬂmtmindim

mboingmdeby:

-

Wmta

Nina Max-gm K. Taylor

ale C.I.N.P. Secretariat

If you

Strut,
D. C.

mm,
an planting to attend thia misting,
3836-1613:

NJ).

20010

to m directly?

would you

writa

m.wmmrlwkfmmmhavingyoujoinusin
Magma».
8W1y' yours .
Hm:

Pink,

PM).

'

Profuse:- of Paychiatxy

�</text>
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                    <text>June 21, 1963

emu

Hind}
Dr.
Galesbm'g State
Saleem

Rem Hospital

Illinois

Dear Bax-old:

Enclosed am mfemnoes cmoerning

W

eminence with variam hellunimwﬁe
effecm on the eleetmenoemalom
I lock fmﬂ to your mview with
interest.
Sincerely yours.

m
m.
Director
Maw

macaw

Me Do

my

and

their

keen

�</text>
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                    <text>January 11 ,

1966

Dr. Harold E. Himich, Md).
Director, Research Division
Galesburg State Research Ibspital
Galesbur-g, Illinois
Dear Harold,

I have spoken to Dr. Brill regarding the assignment
of our panel during the {cramming CINP matings. He
indicated that there was still sufficient ﬂexibility in
the program, that if I were to indidate our needs, he
believed he could diamante us.
write specifying the times that you
prefer having this panel on the pregnant! and I will
then write directly to him making a specific request which
Wmld you please

would

can meet your needs as well.
Many

We.
Sincerely yours ,
Fink. M.D.
Professor of Psyd‘xiatry

Mex

�</text>
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                    <text>January

18 , 1966

Dr. Harold E. Himich

Director, Research Division
Galesburg State Research Hospital
Galesburg,

Illinois 61ml

Dear Harold,

I are pleased to confirm the invitation for
your participation in the ,Simposim on Anticholimrgic Hallucinogms
at the {cramming mting of the GIMP, to be held in Washington, D.C.
Dr. Bradley and

on Hatch 29 and 31.

We

look forward

to the presentation entitled

Exmination of a Possible Cholinergic Link in the EEG Arousal
Reaction,” by Dr. Z. Cumilio and yourself. As there are still a
few questions about the ability of some of the European invitees
toattendthe meeting, itwillbeefewweeks beforeweomsend
"An

'

a definitive

prom],

rim-29¢

mi. 47:12.. as...

Five reports will be presented during each three hour session,
allowing thirty-five minutes for each presentatim and discussion.
Since the discussion may be of special interest to the participants,

thereportshouldbeabmrt20 minutesinlength.

'

'Iha CIHP has permitted us to consider the publication of this
symposim separetely. Imofer as this subject is becoming increasingly

iwortmt,

believe that the associatim of the work of the
participants in a single value will be a valuable contribution,
and ask your cooperetim in making a manuscript available at the
time of the meeting. 'Ihs manuscript should be approximately 20
pages of text, plus bibliography and illustrations.
we

‘

to the date of your presentation, I have just
received Bulletin III of the GIMP which indicates that om- section
will take pleoe'fuesday morning and all day ’mtmsdsy. Rather than
With regard

askthergxunmaimtoalterthapmyem,wewillsdxedule

it
for the side trip you have
mgmnts
We would be very pleased, however, if you could attend

your presentation for Tuesday muting. This should mks

pmsible for you to

in

mind.

make

�Dr. Hiwich

January 18, 1956

~2—

all,

aims your
the Thursday session as
of
the
mating.
this
M1)! to success
ﬂy

but

experima would contrimte

regards.
Sincerely yours ,
Ha: Pink, NJ).

Professor of Psychiatry

HFﬂcp

'

P.S. Siam an would like to print a program including abstracts

fordistributimatthemting, wouldymfavormbya
single paragraph or

two

describing your pmmtation?

�</text>
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                    <text>“binary 9,

1966

Dr. Hamid E. 811mm
March Division
Saleaburg State Research Mimi

Mm,

8mm, Illinois 81ml

Dearﬁarold.

I

do hope

that

we

will have reprints available for the

Itiamminmﬂmtn
pxwidaamodwlunmdlmmﬂmtmpublimrwin
available.
papers mzbmittedattrasymoaim.

momma

Thank yen wry much for your abstract. I look forward
to wing you in Wmhhuton.

Sinmmly yam ,

am, PM).
m
Professor of Psyd'datry

�</text>
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                    <text>r
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rubrunry 25. 1969

wilhol-lun Iﬂlwlch
Chair-an. Cal-lttoo an Award.
duality of Biological Psychiatry
Galcsbnr; Btato Randarch Hotpltal
Dr.

Gal-nburg.

Illinois

SlAOl

Boar Ullhcl-dnd.

It xiv-u both A1 Prouduna and nvuclt grout plnnnarn co
nub-1t the cacloood rlporz ontttlad, "8.: Ratios of marketain Puorpcral Schisoyhrtnll - A rhyslologlcal Interaction

Bctvudn Hothnr and Fauna“ by Dru. Hichnnl Tuylor and Robert
Lariat, to: tho consldordtloa of the Connlttou on Award: for
the A. E. Itasctt award.
Dru. Taylor and Lavina are in

.
—.

v

training at our Ccllcgo. During

thcy undcrtook ludapdnd-at rosadrdh

Amwnvv’m

lath

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E

1n paychopharuncology,

Al and

I

found tho rnport

at special lnrorurt. for if

furthcr :tndlad vurify tho nuggodtlonr undo, than thay provide
important cvldcnco for the blolealcnl ucchaalruo of schizophrcnln

and Inturnal—fotnl
Uh

4

projcct:

also
his. to collabordeu in the vcrltlcactoa of an
lutnroctln; rtport by aboard: lﬁwil; relating Id: of offspring
to maternal paychouiu. Finding that the local data did indeed
conflrl that ruporc. they sought ottcctn in the pout~partun
parted: and in davuloplu; soup 331-11 :05: trialu. 1h. lattor
urn umduruuy and thc data too prollnlnnry to ha in this actuary.
found

and
“-1va

that: third ycar of rtnldcacy
that: olccttvu crnlnlng period.

con-and

on Awards.

incarnationu.

this rcport to tho condtdoraclon at the

ﬂat bar: ragardr.
Sinecrnly yours.
Ha: Flak. H.B.

Professor of Psychiatry

Mlzkp

cc: A. H. Pracd-da. H.D.

Committed

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                    <text>Hay 11. 195:;

“111mm ‘15 31.1“}!
thaibur; Sguta nasourch Reunital
Galotburs. Illinois

”to

Dan:

Hillilninn:

wire wanted during tho amazing; of ch: Society 6! Biological
Psyghiatry, but an ware all pleaund to hear that you and Harold
war. in Burupo.

You

associates, Sal Gershon, hcard the report givun in
Chicago at the rbdntntion tastings, and has asked.uhechat we can
obtain a copy of your paper. Io: ch: past 16w aback: we burn

an; o!

my

aonsidutué rueording our 2363; using a talcuntri¢ apparatus. and
at Eh: prcucat tin: have found no gas «he in sari-find with his
cquipnaut or tuchniquca. Apparently. you hav. been succalaful
and I would b¢ pleased to know aor¢ of the details at your rucord~
in; aquipuant, and the electrodes spacificnlly.

I trunt

ynur

trig ht:

been a successful one.

Siuccrcly yours.
Kn:

rink. n.9,

«airucter
air/3h

�</text>
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                    <text>April

5., 1986

Dr. L. R. Hima

of Biolagical Research
War
301?“?! La m. me.
"’

Nutley,

New

Jersey

07110

markuﬂinoa:

Immufulforﬁmoppommitymdewribeauramdy
pmgmtoyou. Immmubwtyofmingmpﬁnts

ofmpmaentmrktomamooiate,m-.Eminﬂ.mim,

demtthatMvdllaMmtmwithyw.

Mmfaryminteﬁat.

Sincerely

yum,

Fink, PM).
Professor- of Psychiatry

Max

Hf‘mp

�</text>
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                    <text>%
',"1

Wygqu-w-v-

7383691

June 13th, 1973

Virgil A'o‘ Ph¢0g ”.D'I g.
President. Hediaal Atr:1rl.

V10:

‘

ALEA

Corporation‘

Boar

Virgil.

,

950 Page Mill Read.
9310 Alta, Cﬂifornil, 9530);.

I havu road the proposnl
antagoniut’with grott intcrtitw

tar

It

narcotic
;1:long-acting
a drtnntic ind

protonsignsl prcucnma$ion‘ The introduction 1:
toehnieully and losieally carruct - Sadned, your stuff
has done an excellent 36b in sttting the problau.

furtharnoro, the style of pretentgtton of clinioul
tanting in sodsta and apprayrintc to a preposal which 1:
rbcusned on the duvolopnnnt o! s dcvico. You indicate
:3 mittens»: or the importcnnc of clinieul testing. :nd
yet leave open tbr the contruetins usency to select it.
taut: of testing.

I ﬁbula be optimistic thnt should the committcos
be 10:10“: dbout this npproach, thcy ﬁbula conaiéor this
applieution favornhly. I would be pleased to tactic you
in nu:

that I can.
belt rugnrds.

way
my

Sinnnrcly yours.

ﬂux Fink, M.D.

Pratt-nor of Psychiatry

hill:

�</text>
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                    <text>n‘w‘

Va.

r-

-

vm

uw

4v

m

«wu—

--

.

~

W “fl-WW"

1-:

v.

,

rdm'wv'nvv"mwl'melwvva—H."IMF—VJ «.wi van

:-

Fabruary 22, 1972

Binaa, Ph.D.
Director of Biological Research
Hoffmann—La Roche, Inc.
Nutley, ﬂew Jersey 07110
Mr. L. R.

Dear Len:

I hava read the data ahaata on Lorfan and RD 6-6711 with
interest. ﬁocuaaing on thair possible uaa in opiate dapandanca.
The data on Ro 4~67ll ahows this to be similar to cyclazocine in structure, with similar side—effects on low oral dosage
(0.5 mg) - sleepy, uncomfortable thoughts, “drunk",bhtt with
vomiting also. Thasa effects reflect a nigh dagraa of agoniatic
effects, canaidarably reducing our intaraat.
data on Lorfan is more promising. It is a well defined
antagonist, and a program dcaignad to extand its duration of action
may be useful. It may be important, howavar, to clarify the commant
in the packaga insert, regarding enhanced respiratory dapraasion
with repeated doaaa. If varifiad, this will be a deterrant to further davolopaant.
The

Thanka

for the opportunity to raviaw these data.
Sincerely yours,
Fink, ﬁ.D.
Professor of Psychiatry
Max

�</text>
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                    <text>March 1, 1970
Dear Professor Hippius,

for

I am writing on behalf of Dr. Milton Kletzkin,
membership in the CINP.

I have known Dr. Kletzkin for more than 10 years,
and followed his work with interest. He is an experimental
neurophysiologiet and neuropharmaoologist with special interests
in the the effects of muscle relaxants and sedative anxiolytice.
He is a fine speaker and has contributed intelligently to the
symposia in which he participated.
At the recent meeting of the program committee, I
put forward a suggestion that a symposium be organized to
relate the CNS effects of drugs in various animal species,
and I had his cooperation in mind for that program.

It gives

me

pleasure to

recommend

his

membership.

Sincerely yours,

Max

Fink, M.D.

New

York Medical College

Professor of Psychiatry

Prof. H. Hippius
Nervenklinik der Freien Universitﬂt

Berlin,

Germany

�</text>
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                    <text>August 29 , 1968
Dr. Hanns Hippius

Direktor der Psychiatrischen Klinik
Preie Universitat Berlin

II

Nussbamralle 36

1 Berlin 19 Germany

Dear Dr. Hippius:

I am pleased to send you copies of our report on cyclazocine
in the treatment of narcotic addiction as well as preprints of
the use of this drug in the treatment of depression. As I
mentioned to you in Spain, we came upon the use of cyclazocine
as an antidepressant from its m profile. The data is described
in these two reports. Of course, further study is necessary and
I hope that others will make the necessary independent investigations.
My

best regards .
Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

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                    <text>September 3, 1970
Dr. Hans Hippius

Nervenklinik der Freien Universitat
Ulmenallee 30
1 Berlin 19, West Berlin
Dear Dr. Hippius:

First let

me

congratulate you

on your

election

as

President-

implied criticism of the
Elect of the
had
more
to do with the patent
actions
nominating committee's
America, particularly
from
CINP
North
of
the
rejection to Fellows
of your nomination
criticism
than
any
the United States, rather
which I endorse
nominations
both
or that of the new treasurer,
GIMP.

You

know,

that

my

heartily.

I am

As

writing because

I

am

interested in the

I discussed with you, the data suggests that

new drug,

it

may

psychoactive properties and as such I an interested in

sulpiride.

have unique

its

EEG

profiles.

I would be grateful for any preprints which you may have of
your work or that of Dr. Degkewitz, as well as any pharmacological
data which may be useful to me.

Also, I would appreciate the

may have

It

studies this

was fun

names

compound.

German CINP

My

and I hope that I will
see you sometime soon in your new laboratories

sessions

—

interest to participate

once again

the ones in Nurenherg were most stimulating.

best wishes for your success.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HFtkt

who

getting together in Istanbul

have the opportunity to
in Munich. Perhaps it would be of

in the

of any investigators

�</text>
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                    <text>V_V_...._—r

www-vw‘wmnw.—rv.m "Wm—-q‘mnmnmv‘w.w_n.—mm.. V—__Y.._..V..._.,..

vamv

October 24, 1963

Dr. Rabat much
63 Station Road

Gnu? Nock,
Nam York

Long blend

Daniel»:

lmwmnﬂhhlmwnhmﬂo Dr,

Admkmnblmvhoha

'

Indiana a dam *0 Mn this Institute fat the fhhd year of Ms 1"!qu

Wm and, upon complcﬂon, «mm. on In ”ch.
Ha

ha 9km your name as a «furnace and I would be mad cmcluﬂvu

W

fat your comm raga-ding his punctuality and his plot-sienna!
I am poniwlcrly Maui-d in Dr. Ronald-ﬂ": psychoanalytic

with you. i would b. «wholly match»! for any
to min «9:6th his ranch dainty.
My

War».

emf; you might with

but taco-d5.
.

“manly yours,
Mu ﬁnk,
M935"

MW

‘

M. 0.

�</text>
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                    <text>A

State University of New York at Stony Brook
School of Medicine —— Department of Psychiatry
Max Fink, M.D.
Professor of Psychiatry
PO. Box 457
St. James, New York 11780

/

/4
jail”!
9?

b

'

Phone: 516 444-2929

516 862—6651

Fax: 516 862-8604

July 23, 1994
TO:

Robert Hirschfeld, M.D.

FROM:

Max Fink, MD.

Subject:

Ted Hutchinson’s memorandum14 July 94

M

Ted is a lay-person who was advised that his son needed ECT in California,
and he came up against the community prejudice and legal devices to frustrate its use. He
succeeded in getting treatment which was most helpﬁil. Since then, he has read widely in
ECT, developed a unique knowledge of the legal issues, especially those affecting the
FDA, and the role of the anti-psychiatry movement in the US. His ‘alerts’ to members of
the ECT community are respected.
He was instrumental in getting D. P. Devanand, Tom Bolwig, and Harold
Sackeim to compile the data in the reecent review of the pathology of ECT, the review
appeared in the recent number of the Am. J. Psychiatry. [He is a co-author].
I take his advice seriously and respect his knowledge.

The APA Task Force on ECT, headed by Richard Weiner, was establsihed
in response to requests for advice by the FDA in 1981 or 1982. It is still responding to the
FDA, and you may wish to get his advice, to correlate your responses. [Te1: 919-681
8742}

�</text>
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                    <text>r
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February 7, l968
CIA. Hispanoamericana de Turismo

Paseo de Gracia, ll
Barcelona 7, Spain
Gentlemen:

accept the reservations made for me at the Imperial
Tarraco.. It is not clear to me whether you are expecting
prepayment or not. In the meantime. please accept this
I

reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 17 ,

Mr. Edd T. Hitt
Misaouri Association
Mental Health

1961+

for

Jefferson Stmet
Jefferson City. Pﬁssouri
705

Dear Mr.

ﬂirt:

pmsent plans call for me to leave
for my vacation on or about July 29.
I will be pleased to meet with your Task Force
on July 27 ca? 28. I would prefer- to have the
grmp meet as early in the naming as possible.
My

31:. Louis

I look forward to meeting with our many
frianm of the Missouri. Association for Mantal

Health.

.

Sincerely yours,
Max

Pink,

Dimctor

M- D.

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Department of Psychiatry and Behavioral Science

HEALTH" SCIENCES CENTER

State University of New York at Stony Brook
Stony Brook, New York 11794 / (516) 444 2413
——

June 9, 1977

Hittman—Medcraft Incorporated
P. O. Box 5h2
Skippack, PA 19h7h
Gentlemen:

I
as

would

like to obtain descriptions of your

available today,

specifications that

and would be
you can send.

descriptions of electrodes
Many

thanks.

grateful for

EST

any

instruments

price

In addition, I would appreciate

and other devices for EST.

Sincerely,
Fink,
Professor

Max

Mszg

list/

M.D.

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                    <text>April 22, 1971
New

York

Hospital

Medical Systems and Computer Services
525 East 58th

New

York,

Attn:

New

Street

York lOOZl

Mr. Roy Hjelmar

Dear Mr.

erlmar:

enclosed check in the amount of $180.00 (#l23574), was
erroneously received by us, Since the disk packs which we ordered
on P0 508852 should be paid by us.
The

You

few weeks.

should receive our check for the disk packs in the next

Thank you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>January 27, l969
Dr. Hudson Hoagland
The Worcester Foundation

for

Experimental Biology
Shrewsbury, Massachusetts 0l545
Dear Hudson.

of our resident physicians. in following a clue
described
by Shearer et al., developed some
recently
”novel" ideas about the schizophrenic process. These
concepts are based on presumed hormonal effects. As no
one here is qualified to review these critically, we are
enclosing a draft summary. I would be most grateful if you
could review the data and provide a candid opinion as to
Two

its merits.
like

In the event the material has some merit,

an opportunity
Many

we

would

to discuss the next logical steps.

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>r‘

WWW-r

WW

—:r.--&gt;- -»

- ”-rv‘r'ni-‘Il'rv'

«u

T'w-va-rmx‘y,

.,

..

‘__

_.‘..

,N, ,.

,

March l3, l969

Dr. Hudgon Hoagiand
222 Maple Avenue
Shrewsbury, MassachuseTTs 0l545
Dear Hudson,
Thank you

The manuscrist abouT sex—raTio and
your commenTs. The daTa are small and

for reading

schizophrenia and for
require furTher duplicaTion and eiaboraTion and we are proceeding
wiTh Two proJecTs - one To repiicaTe The flrsT sTudy and one
To predicT The sex of

picTure.

offspring

based upon The maTernai

clinical

ThaT The preposed hormonal mechanism is speculaTive.
ThaT
The
clinical Trials ciTed in The manuscrist auggesT
However,
The adminisTraTion of TesTosTerone or progesTerone can enhance The
TherapeuTic effecT and decrease The relapse raTe from ECT. Torghele's
successful TesTosTerone-ECT TreaTmenT of chronic, Therapy—reslsTanT
schizophrenic women furTher suggesTs ThaT These hormones may
affecT The psychoTic process.
I

agree

difference in produchon of TesTosTerone and progesTerone
and female feTuses ls a crucial quesTion. WheTher
male
beTween
The difference ls in amounTs or in funchonal achvlTy of feTal
TesTosTerone or in The feTal meTabolism of placenTal progesTins
To androgenic forms is noT yeT known, buT such a difference
would indeed sTrengThen The argumenT. The possibiilTy ThaT These
hormones may affecT The chromosonal DNA codons in The defecTive
parTiculariy inTeresTing,
offspring (all defecTs were in The CNS) isinTellecTuai
funcTion
of
increased
DalTon's
reporTs
in View of
of
progesTins
dosages
received
high
moThers
in children whose
in The early pre-parTum period.
The

The quesTions you

raise should

sTimuIaTe Taylor and Levine

in furTher invesTigaTion and They and l Thank you for your Time
and commenTs. They will be presenTing This daTa aT The SocieTy

of Biological PsychlaTry in
This furTher aT ThaT Time.

May

and

i

look forward To discussing

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

Mszp

wwmm,

-

van-'ervv

414.”

�</text>
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                    <text>November 28. 1962

Dr. Paul Hooh
Department of Mental Hygiene
Albany, New York
Dear Paul:
During your recent visit to St. Louis. the local newspapers
carried a summary of your remarks which. in their brevity, were
tantalizing. The essence was supporting of the present programs
of Dr. Ulett to such a degree, that I am writing to ask whether we
can obtain a copy of yom' report as well as permission to quote from
it in preparation for his presentations before the legislature of the
State of Missouri. As you know, we are embarked on developing
programs in Missouri that in many ways follow the leadership of
New York. We are modeling om' Institute along the lines of the
New York State Psychiatric institute. and your remarks may be
helpfultin presenting some of the statewide programs.
Thank you

vm much for your cooperation.

My beet regards .

Sincerely yours.
MISSOURI INSTITUTE OF PSYCHIATRY

Max Ftnkg M. B"
MFtaw

Director

Please address oorrespondenoe to: 5400 Arsenal Street, St. Louis 39. Mo.

�</text>
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Pool Hook. M.D.

Con-isotoner
Department

State of

Albany,

If

Mental Hygiene

York
York

New

How

Deer Poul:

interest

and since I have referred to none of your early
taking the liberty of sending you this copy of a report
on the effect of Chlorpromeline~Ptooyclidine in the treetnnnt of depreee-

Knowing your

etudiee. I

em

iv: dieorders, which has been ecoepted for publication by layohOpherme—
oolosie. I an also toting the liberty of enclosing e copy of the presen—
tation the: I made at C.I.N.P.. as this may be of some interest to some
of your investigators.
My

beet regards.

Sincerely yours,
Pink, H.D.
Director

Me:

nl/le
Enclosure

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                    <text>Scptembor 21. 1964

Paul Huh,

MOD.

Commissioner

Department if Mental Hygione
State of Raw York
Albany, How York
Dear Paul:

I hero roferred to some of your early
taking the liberty of sending you this copy of a taper:
on the effect of Chlorpromazinowrrocyelldine in tho treatmont of doptcns1v: disorders, which haa been accepted for publication by lsychopharua—
cologit. I on also taking tho liberty of uncle-lug a copy of the pressutation that 1 mode at C. I.N.P.. as this may ha of sums interest to sumo
of your invosclgators.

Knowing your

studies. I

My

interest

am

and since

boat regards.

Sincetoly yours,
Fink, HOD.
m
Director

mills
Enclosuro

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                    <text>Dow 18,

196k

Mm.Pmlﬂoch

Wtofrhntalﬂygiem

Albmy,NwYmk

Dorm. Roch:
Itwaswiﬁzamatdadofmmtthatlmad
ofPaul'sduth.

ItwmmlyﬂnwookwliwthatIhad
multisfnctim ofhavinglmda wiﬁmhimatmesociety of

Biologimlhydﬁauy,mddm~ingthatdismsimhetoldm

ofhiommyplauformw‘lmm. mmhuItimofhis

M

integrity. vision, and scientific
«1mm.
befomdsomadilyagaininﬂmmricmsm.

will wt

linwuaﬂmtemr,mdamatluder.

mpmadtohawlamhim.mdtohaveworkodwithhim.
Simmly yours ,
ﬂax

PM, ED.

I

Rssaamh Professor of Psychiatry
Washington University
mfzdk

�</text>
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                    <text>May

mar.
State Hospital NO.

Emmett Po

M.

23, 1963

D.

1%

Pamington, Missom'i

Dear Dr. Hector:
Aeywlvcmw, Dr. GeorgeA.

Ulettheseskedusatthe

Hieeouri Institute of Psychiatry to direct

activities

some

of

own

resemh

treatmt resistant schizowould
like to participate in a
if you

toward the prbblem of

phrenics. we wonder
small study with us. What we. wmld like specifically is to find
of sdmiwphmdee between the
of 2D and 55, mo
a
2
8
and
have been hospitalized between
yearsand wm are not now
We
like to match these
receiving any psydwtropic agents.
mid
who
with a similar group fmm our institutim
am mceiving

M

mailim.

EEG

W

'

to visit with you, yaw
m
WW3
out
cf the details
tedmician, and your staff to
Perhaps we

wild

for such a project.

work

some

Sincerely yours .
Fink.
Director

Max

Mair

H. D.

�</text>
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                    <text>May

Prof. Dr. T. Vbssenaer

Scientific Development
1‘;

. V.

Organon

Oss , Holland

28,

1971;

Group
.

Dear Jack,

I received your letter of May 17 as I was leaving for the
in Florida and was able to carry through on some of
while I was there.
suggestions
your
In going ower the GB-Qh data in Des, I became concerned with
two questions: the range of the differences in the date from each ine
differences in washout period, use of other drugs,
vestigator (i.
rate of dose increase); and the manner of handling the data reduction
(1 missing data, symptom scores vs. global scores, equivalence of
populations in the two samples). While the data may be in better 'shape'
than presented to me, and the processing may be quite satisfactory, but
I expressed my anxiety to Honk since so much (for Organon and for EEG
research) hangs on the analyses.

ECDEU’meetings

e.,

e.,

In answering your questions, I propose you allow two steps
in getting the answer: a preliminary review of a sample of the data
by the Biometric Laboratory in Washington, and a.more detailed review
soon thereafter by yourself and Mr. Stulemeijer with either a larger
sample or the total available data. The preliminary review will permit
Drs. Bonato and Guy to become acquainted.with the details of the study,.
and to relate the design and the problems to other studies that they
may

have analyzed.

If these steps are acceptable, I suggest that one set of
data sheets from one investigator be sent to no, as a sample of the
data. In addition, it would be helpful if we could have an estimate
of the total data available in a form similar to the outline attached.
I will send these to Drs. Bonato and Guy, and will plan to meet with
then to go over the prdblens and possibilities for analysis.
Based on these reviews, I will call or cable you defining their
suggestions and outlining the times available to them. I beliehe you

should review the data processing in their laboratory, not only fer its
statistical sophistication but for their experience in handling diverse

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page 2

date from diverse pepuletion annual“.

If these

suggestions are egreeeble, I am able to cooperate
any time up to July 20 when I plan to leave for Europe to attend the
meetings in Utrecht.

I thank you for your cements about. Dr. Dolce, end I agree
with your decision. I look forward to meeting Dr. Grosveld; hopefully
we can meet in late July in 033 or Utrecht.
I am enclosing a. com! 01’ e note to Heal: regarding the
ECDEU meetings, and w visit to Joyce Smell
swung her exper»
'

ienee with car-63 end caugh.

My but regards. I look forward
United Stetes in Jme or eerily July.

to

welcoming you in the

$1110.“er your: ,

Fink, M.D.
m
Professor of Psychietry

.1

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                    <text>vawwr
'3

r .-——-—w.-m.....nwwvwryuﬁx-‘vmj-IV'

-

“nuns "Wu '7. 'mﬂ,*\ww~v-I\Winlnwm

W‘- y-o-‘a‘w-p-“szvnW‘s"! -rL—mm—W‘..w.~,‘ "n”- .m»....,... “v.3.

......—._..

7..-..1WM

w

w." .......

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s‘r"'w:~n

~

March 18, 1975

Robert Marc Hodges,

D.

M.

3720 Hampton Road

Pasadena, California

91107

Dear 'Dr. Hodges:
To

the best of

my

knowledge. no formal documents exist

any of its affiliated hospitals regarding
of
use
any treatment. Such decisions are left to

this University or at

at

cri~
for
the
the
teria
attending physician, subject to the reviews by appropriate Coﬁmittees
of the institutions concerned.
For our teaching of biological psychiatry. particularly
indications for and the methods of ECT, we usually cite our own
publication of 1970 (Convulsive Therapy - Methods and Applications),
the 1972 special issue of Seminars in Psychiatry dedicated to
Convulsive Therapy, and the l97h volume, Psychobiology of Convulsive
Therapy, edited by M. Pink. 8. Kety, J. McGaugh and T. Williams,
(Winston. washington. D.

I trust these

6.).

comments are

helpful.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

.

.m

..

.- ._‘

.

,V

w. w

_.

..__...,_ . ..l._ v -7.

�</text>
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                    <text>September 9, 1979
Dr. R.

M. Hodges
3720 Hampton Road
Pasadena, Cal. 91107

Dear Dr. Hodges,

of the

Enclosed are a number of reprints of our recent studies

effects of drugs.

We have two applications of these methods—and classify putative psychoactive agents, and to describe
the phramacddynamics of the compounds.

EEG

to identify

In our work, we use an IBM 1800 which was programmed mar
machine language more than 12 years ago. I fear that these programs are
of little merit to any investigator wishing to program modern machines.
The logic of power spectral density is published in engineering volumes,
particulary by Blackman and Tukey (Measurement of Power Spectra, Dover,
N.Y., 1958) and that of period analysis by Burch et al (Ann. N. Y.
Acad. Sci. 115: 827—893, 1964). The most recent descriptions of programs
(HZI Research,
for small computers were those written by Dr. T.
150 White Plains Road, Tarrytown, N.Y.) and Dr. D. M. Shapiro (2 Hemlock
Drive, Kings Point, NY 11023). Dr. Shapiro is a computer consultant who
programmed my machine and a number of successors, and you may wish to
write to him for the availability of programs and their translation for
your instrument and purposes.He would be particularly helpful in advising
you as to the feasibility of doing BEG spectral work on small instruments
of the kind that you describe.

Itil

Thank you

for your kind

Good luck

in your work.

comments on my book on ECT.

It

has

received a favorable review in Lancet and has been awarded the 1979 prize
by the Anna Monika Foundation of Germany for its contribution to the
study and understanding of endogenous depression.
Sincerely yours,
Max

Fink,

M.D.

PRofessor of Psychiatry

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                    <text>March 3, 1966

Paul B. Phebe:-

‘

Harper 8
49

Raw

Publishers. Inc.

East 33rd Street

New

York,

New

York 10016

Gantlemm

in

m quamtitativa analysis at ehmgea

aim
of special intemst. M
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tbs warms of evoked potentials and
my
in electrical

mm has become an inportant tedmical application of digital
couputw mthods . Of the specifics ayplieationa, those to

electmancephalo

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effort
exmllent reports have been written.
hag gone

7

th

The

olectrmic

of

methods

analysis have mntly bean summarized by a popular review
written by two Swim: authors and distributed in
by the
of Comma .

Whﬁm

Athr aspect is the deacriptian of dangers in frequency,
pattern and 3112911th wanking from anaeﬂxesia,» dwgs,

sleep, etc.

These labomtorias have developed vwious applications

digital

queats

for mesa-Inmate.

of

my
favourpmm mdhmbemm-gadmsmizaﬁﬁs
methods

We

haw received

m-

informﬁminatedmiwlmml. webalievethatthmia

mdforsudzatwmimmmtohemmgamlly
wad are amazing it to you for your consideration for

available

publicatim. If this interests you, we mid be pleasad to
discuss mﬁfieatiom md Wimtims that may be necessary
to pmviﬁe a mom gmmlly applicable document.
‘mank you

for your midshatim.
Sineemly yours ,
Max Films, H.123.

Mower of

Psychiatry

�</text>
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                    <text>Mast

WMm

Mr. Human Hoffman, Acting

State

Win}.

13.- 1963

Motor

for Sm'plus Proporty

Jafferaon City. Miaaowi

Hoffm:
Minoan Institute of Psychiatry 15a research laboratory

Dear Mr.
The

of the Divisim of Mata). Diseases of the State of Missouri. We
have need for electronic aquimt whim is ﬂagrantly available

as surplus property through agencies such as We. I mule!
appreciate some information as to the applioations that may be

for this laboratory to obtain lists of available
mom
equipment
surplus
at ﬁveqmnt intervals.
Thank you

for your cooperation.
Sincerely yams,

'Maxf'idC,H.D.
Director

�</text>
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                    <text>November 22, 1985

Kurt R. Hoffmann, M.D.
Boehringer ingelheim, Ltd.
90 East Ridge
P.O. Box 368
Ridgefield, CT 06877
Dear Kurt,

it was a pleasant surprise to receive a gift of holiday wine. In past years,
these vintages have been excellent, and i have come to reserve them for dinner
with my special friends. Thank you for your thoughtfulness.
During the past year, I have put aside my work with pharmaco—EEG and
devoted most of my time to editing a new scientific journal, CONVULSIVE
THERAPY. i received the invitation to organize the journal in July, 198% agreed in
September; and the ﬁrst issue was mailed in mid-April, 1985. Succeeding numbers
appeared in July and September and the fourth will be mailed the first week in
December. We are on a good schedule now, and i think the journal will be accepted.

it has been much work, but i have enjoyed it. From time to time, i regret
not working with our volunteers and with the EEG graphs, but that work continues
in the hands of others.
i trust the year has been a good one for you. My thanks again, and my best
wishes for a healthy and a happy 1986. My best regards to Penny.

Sincerely yours,

Max Fink, MD.

Professor of Psychiatry

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                    <text>May

24, l968

Friedrich Hoffmeister
Katernbergerstrasse 262
Huppertal-Elberfeld
Dr.

Germany
‘

Dear Dr. Hoffmeister:

.

_,

,.,‘.

.,...w

w.“

.‘a‘wuqu

It

pleasure to hear your report at the CINP and to
discuss the problem of narcotic antagonists with you. As I
indicated, we are particularly interested in the use of antagonists
in the treatment of opiate dependence. Two reports of our work
have already appeared. and a third is in press. I am enclosing
preprints of each of these.
was a

aspects have been of special interest: the potential

Two

use of cyclazocine as an antidepressant, and the expense and
short duration of action of naloxone.

With regard to cyclazocine as an antidepressant. we were
stimulated to these trials by the similarity of the EEG patterns
of acute and chronic cyclazocine to that of imipramine. In two
clinical trials. we are impressed that cyclazocine is indeed an
and the preliminary reports of that work are
antidepzessant
enc ose
.

But it is the antinarcotic activity of naloxone that holds
the most promise. Because of its short duration of action. not
exceeding 4 hours in our trials, it may not be useful in clinical
treatment. We are encouraged. however, that other antagonists
similar to naloxone may be available in the chemists laboratories compounds with similar potent antinarcotic activity but of longer
duration - hopefully with as long a duration of action as the
long—acting depot fluphenazine enanthate or decanoate. We are
interested in hearing from you whether Bayer has such a compound

available. and if so. whether it is available for clinical trials.
there other laboratories that may have a long-acting narcotic

Are

antagonist?

�Dr. Hoffmeister

I should

-2-

May

also like to take this Opportunity to invite

24, 1968

you to
next you visit the Uiited States.
I would like to review our programs and to arrange for you to meet
the Chairman of the Department of Psychiatry, Dr. Alfred M. Freedman.
who has stimulated these studies.

visit

our

clinical facilities

Thank you

when

for your assistance.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

�</text>
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                    <text>September 4, l968
Dr. F. Hoffmeister
Institute of Pharmacology
Farbenfabriken Bayer A.G.

Wuppertal-Elberfeld
West Germany

Dear Dr. Hoffmeister:

During the CINP meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist, whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
We

and I am pleased that we have
clinical supply for studies that

also discussed naloxone

been able to obtain another

are now in progress in the treatment of opiate addiction. Of
course, we are interested in other narcotic antagonists, especially
those with a duration of action longer than naloxone.

trust that you will have
your next trip to New York.
I

on

an opportunity to

visit

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

us

�</text>
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                    <text>,v

"gr-w

m

np—~

—

m

raw—me

September 4, 1968
Dr. F. Hoffmeister
Institute of Pharmacology

Farbenfabriken Bayer
Huppertal-Elberfeld

A.G.

West Germany

Dear Dr. Hoffmeister:

meetings we discussed our common interest
in anticholinergic drugs. Cyclazocine is an active narcotic
antagonist. whose EEG profile is similar to that of imipramine.
From this observation we decided to measure its antidepressant
activity. The summaries of our two studies are enclosed.
During the

CINP

also discussed naloxone and I am pleased that we have
been able to obtain another clinical supply for studies that
are now in progress in the treatment of opiate addiction. Of
course. we are interested in other narcotic antagonists, especially
We

those with a duration of action longer than naloxone.
I

trust that

on your next

you will have an opportunity to
New York.

trip to

visit

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

us

�</text>
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                    <text>February 21, 1975

Dr. F. G. Hermann.
Columbia University College
Physicians and Surgeons
'DO West 168th Street
New York, New York
10032

of

Dear Dr. Hotlinn:
.

for sending me e
It is well written

Thank you

Alcohol Abuse".

copy of "A Handbook on Drug and
and reeds easily.

Since the time when we chatted about the narcotic antagonists,
been some progress - notably, much testing of neltrexone has
has
there
shown this drug to be superior in efficicy and toxicity to cyclezoeine.
Chen next you issue reprintings, it would be helpful to bring this
section up to date, as the work is active.
Again,

my

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Hex
MF:ed

�</text>
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                    <text>January 21,

Dr.
3%,

J.

196*;

C. Holden

8mm

Lane

metmuood
Nr. Warringtm,
Lamashim

England
Dear-

W. Holden:
Your

to be very web in owe-r, and
them. I shall mien the further processing

application a

libemyofwxi'ngtosmeofﬁmmfemea. Assam
Imtakingﬂu
rave
as I

Mud

fm

of yaw application.
The 3cm; certificate is a requirement for all medical
positions in the States. while it mid be a formality for am with
your experience, it is a mguirmmnt which mot be avoided. I
muldtmgeyoutomkeapplioaﬁonatmpmcnttim forexmaination at the earliest oppm'tmity.
Sincerely yours ,
Max

Fink,

Director
Mfmlg

M.

D.

�</text>
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                    <text>detuary 25,

1964

Drl J. C. Holden
34, Green Lane
Buttonwood,
NI. Harrington.

Lancashite,
England

Don: Dr. Roldan:
have you join the 03:1! of ch: Misaouri
Institute of Psychiatry an a Research Fallow on or about
June 1. It it my expectatian that as soon as you hava Incia~
factorily coumlnead ch: ECFHE examination. you would b:

I will be pleasad to

imnndiatcly cligibla for the position of sanior Resatrch
Scientist (Paychintty).

I shall try to anlwnr oach cf your quoations ragarding the
terms and conditions of amployment. I am taking.tha liberty
of having that part at ya»: latter ragarding living conditions
in St. Lcais ansunrad separately by Hr. Harry Neubauar. Dr.
ﬂanking: is a manta: of thc staff who joiacd us llit March
from Nawcaltleo I am.eonfiden£ thnt they caa unseat your
social quastiona in a more comprehenaiblo fashion than can 1.
position of Rascgrch Fellow carries a monthly stipend of
$900. In gennrnl. the working hours of :hu Institute are 48
hour: per wank. modified at the discretion of the Diroctor to

Thu

suit tha anode of individual projtctu.
your
It is my expectation that during the next few months
and
Tutan
Dr.
myualf.
with
b:
will
lcil
ralatiou
principal
Hi havc oubnrkad on a number of prograam rclitcd largely to

tho projactn are the EEG
changes with ncw paychotropic drugs; computar analyuis of EEG;
classification of schizophrenia cubjneel in terms of their
psychopathology. reactivity to pontoehnl. L89 and Bittnn,

brain function

and bohuvior.

Among

changas on gngnmocncephlography, and mnditicationl produced in

the spinal fluid.

�J.

Dr.

C. Holden

2~25~6A
Pegs Tun

It

wss with regard to your

that

we

felt that

interest in post-lsucotomy subjects

your sppaintnent would be beneficial both to

the Institute end to yourself.

position of s Research Fellow has the limitstion that we ere
unable to offer the ﬁttest participation with the patients in the
clinical verds. At sueh s time es you qualify for position of
Research Scientist, your sssignssnt would be modiiied to entompess
The

some

espect of the clinical research program at the

Institute.

gosition of Senior Research Scientist curries s sslsty schedule
of $12,000 to $15,000 per ensue. In general. increments ewetded
st periods speeifisd by the Director of the Division of Mental
Disesses, and these usually Ate an an annual basis. The Institute
has authority to provide incrsaents for outstanding service.

The

Psychiatric Ressateh Fouadstion is, on occasion, able to
sdvsnce sslsry to assist scientists join the stsff from oversees.
Repsysent is usnelly made aver a period which is convenient to the

The

scientist.

next problem ﬁbuld be that of obtsiuing s visa to the United
States. I suggest that you inquire st the local Consul and he
will indicate the steps necessary to obtain such a document. I
em enclosing s Form 982—66, which may he used to file for an
exchange visitor status. This is e vise which is good for five
years.
I trust this answers your present questiqne.
The

‘

Sincerely yours,
Fink. u.n.
Director

Mex

ﬁF/jb
Eat e

�</text>
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                    <text>Septeube: 29. 1966

Dr.

J.

M.

c.

Holden

Mieeouri Institute of Plychiatry
5400 Arsenal Street
St. Louis. Micsouri 63139
Dear Niko.
Turan was here. HI spoke about the sun's
length. Last night I was reading some
notes from the ECDEU Program and the attached was
included. which I an eanding you for your interest.
I plan to be at HIP next Rodneeday. and I
would be plea-ed if you could work out eon.
tine with Turan for no to go over some of your
studies.
My beet reqardl.

at

When

eomo

Sincerely yours,
ﬂax max,

11.1).

Professor of Psychiatry

81"ka

�</text>
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                    <text>October 10. 1966

‘Dr.
A

M
.

.

.._P,.,

.1“.

3.

—..~n-5w.-v~..—_

--.‘

J. 8. c. Holden

Missouri Institute a: Peychietry
5400 Arsenal street
St. Louis. Missouri 63139
Deer uike.

m.

halo-ed is e xerox of en article from
the October 3. iuue o: the J.A.H.A. which
1: directly relevant to the
me.

am):

you

for spending

no me}: time

with

sincerely yours.
Hex

Pink. $1.0.

Professor of Psychiatry

)1?ka

�</text>
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                    <text>November n, 1966

Dr.

J.

C. Holden

M.

Missouri Institute of Psychiatry
51400 Arsenal Street
St. Louis, Missouri 63139
Dear'Mike,

It has

taken me scmetime to review the laboratory report.
subject is a most inportant one, and especially with the
recent articles which you have read. The major criticism that
I have of the paper is the lack of focus. The introduction is
dedicated to the general problen of laboratory standards, much
as our previous report. The discussion exercises some theoretical
The

aspects of the laboratory test changes, and the methods and

results are a staple statement of some of the changes observed
inourprogem. Ifthereportistobefocussedonlaboretory

data, then the discussion should follow

some

of the similar

aspectsofoxmpreviousreportandperhapsexpomdmfully
on the significance of laboratory tests in the treatment of the

mentally

ill.

Butthiswouldbetoomk. Ifthefocusweretobeon

the significance of laboratory test changes as indices of
physiological effects of these compounds, as seensto have been
the focus in some of the recent reports,,then this document is
deficient in not annotating the other reports more fully.
With

this in mind, I

would suggest

a concentrated review

ofthelitenatmeofthelasttmyear’sontheassociationof

pl'xemthiazineswithsuddendeaths, Newcardiacehanges,
effectsonthevisual systemandonthe skin. Bysumnarizing
these valuable reports, I think you will be presenting a
succinct picture of a major problem. After that introduction,

traspecificaspectsofthedatawhichmfindmmsualinum
long term study patients, can be presented within the context
that perhaps the small changes are still of significance.
My

oaments regarding the present discussion are largely

related tothefact that Idonotthinkweare inagoodposition
to discuss theoretical aspects of clinical physiology from our
vantage point of psychiatry.

I trust these consents are helpful.

My

best regards.

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

Inf 19

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                    <text>‘
&lt;

'

January 9 , 1967

N'H'“

”emu-mu»;

,Wxnw.

V

&gt;

Dr.

J.

C. Holden

M.

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Mike,

It wil 1 be a pleasure for me to participate in the next
C.P.A. meeting to discuss your report on LSDand Ditran.
Thank you for this opportunity to remain an cement with
your

work.

.

told you, we discussed the CDT
have
to
to ask for the Stggested revisions which
he has made and I will then devote much time to some
suggested revisions of the earlier draft you have sent
as well as attempting to incorporate the EEG material. ,
I have received the corrected laboratory print and will
have taken them to the editor personally 0:31 Monday.
'

As Turan must have

mteriel in great detail during his last visit. I
him
written

What

is the status of the are material?
Sincerely yours ,
Fink, PM).
Professor of Psychiatry

Max

‘

MF:kp

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                    <text>“(-1

j.

.

:n.

mum- rv..-~‘~-\~v.--W

:-'-rw'wrrnr.‘n~vyu ;...-.—mw—;

w—w'nwfvwwm—vbr-wv-z,

June
Dre.

J.

C. Holden, Tumn
and Ali Keskiner
M.

,»-

v'

..

"now-w-w-JJ"mom-mmnuwy-um

ﬂv‘“‘--vvu‘vcr—-“—rw*'&gt;—‘v

6 , 1937

Itil

Missouri Institute. of Psychiatry
SHOO Arsenal Street
St. Louis, Missouri 63139
-

DearMike,TuranandAli:
Enclosed

is a draft

the clinical data.

copy of
As you low,

the

first

CDT

report describing

had held this back in the hope
three reports at one time and submit

I

that I could complete all
together to a journal. However, the realities of my present
position are such that I will not be able to complete the extra
analyses that are necessary before the sooner and, therefore, think
it unwise to hold this any longer.
Please read and edit this (5013371 I believe it is straightforward and is eminently suitable for the Mauvu 05 Geneaaz
them

PA

yddmy.

know

With the exception of

of

no

citation

20 which

is incomplete, I

specific questions of mission or errors which may

be troubleeane.

'

After you fave had the opportunity to edit this draft copy
I believe it should be mtyped and submitted to the Mchiuu .

Ifyouwish, Iwouldbepleasedto send itonourbehalf since'
I have had excellent relations with the Editor.
My

'

best regards.

Sincerely yours ,
Max
v

mg...

.v.’

t.

":“"Y

v,

..;..

-“,_.

‘

Fink,-

M. DV

Professor of Psychiatry.

.

WWW”?

--—-.

,

., -.~-

v-v-«www

�</text>
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                    <text>November

'

Dr.

J.

M.

1!,

1967

C. Holden

Missouri Inst1tute of Psychiatry
5400 Arsenai Street
St. Louis, Missouri 53139
Dear Mike.
I

regret to

Say

that the

first report

of the

CﬂT

study

has not been accepted by the Aachéveé 05 Genekat Psychiaxng.
Perhaps you wou1d discuss with Turan and AIﬁ the aiternatives.
Surely. Campnahenbiva-Raychiatny or Psychophammacoﬁogia are

exceient Journals which may consider this report favorany.
For e1ther one, the references may have to be retyped.

If

I can be

of any help, piease call on

me.

Sincerely yours.
Fink, M.D.
Professcr of Psychiatry

Max
*

Mszp

a
A

”WJ’W‘KWVW

�</text>
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                    <text>Dam 16, 1963
J. C. Holden
3%, Men Lane
mutton-mood

Dr.

Nr. Wat-ringtcm,

Lancashim

England

Dear Dr. Holchn:

for your huquixy. The mascuri Institute
of Psychiatry is the research and training center of the Division of
Hantal Diseases of Missouri. It was established in October, 1962. with
laboratory and clinical facilities for maeamh. At the pmaant time,
of 150 beds, we are utilizing 70 for research pmpoaaa. Laboratories
are established in Manley, psychology. and electroencephalography,
as wall as a couputer center for both statistical and BEG malyses.
There is a specialized psychiatric research library as a comment part
Thank you very mach

of the Institute. Mina]. facilitics am

now

being

built.

is a fully qualified three—year psychiatric
at that Imtitutc, and a special training pmprom
gram in clinical paycmlcw is being established. Both in the research
prom and in the training prom, the Institute is affiliated with
In additim, them

maidency training

the Departmsnt of Psychiatry of Wmhington mivemity School of mdicinc.

Mﬁnpmaanttim,t}mmmanunbercfmeamhpmmin

progress. 'Iheae include Lithium as a therapy for mania; the use of
deimbine as a pmcipitant of anxiety and the developnnnt of anti~
anxiety amta; mlatim of EEG patterns and organic factors in the
treatmnt of therapy resistant paycmtica; canputcr analysis of the
the affects of drug withdrawal on behaviw in the
electmphalcm;
amically ill; and tho tmaumnt of psychotics by nurse mlaticnship
therapy.

'

�Dr. J. C. Holden
December 16, 1963
Page Two

Appointments are made
an initial salary of $12,000, with adjmtmnts as my be warranted at
for macaw}: experience and
qualifications.
are
for mntal or for sale within ten
minutes of the institutim. available
While trans,
tion coats to Amrioa cannot be paid directly, it has been the mtablished
tutim to inmo the salary by $1,000 in lieu ofpolicy of the insti~
a direct payment for
transportation. This has the advantage for candidates
who min with
the Institute of providing a higher
base salary in subsequent
years.

mum

I

am

enclosing a chaotiptim of the

Institute.

If this oppor-tmity
appreciate a copy of your minimum
listing
your educatimal and professional swordsman vitae
and reprints
of each of your Mlibatims. if available.
,
In additim, a small photomhmdﬁmmmofat
leasttwomfm
towhomwemywritewould
be amt helpful.
interests you, I

Mohawk

would

It would be most helpful if you wold describe yam present
reso that my madame, Dr. Samuel Gemhm, and
prom,
I could
detemdm
the
search

possibility of its omtinuatim in those laboratories.

Your

letter does

not indicate whether

obtained tho
certificate (Eligibility certificateyouforhave
Hadioal
Pomim
ammo). 'Ihis is pramquiaite to appointmt at the Institute.

E.C.F.M.Q.

Sincerely yours ,
Max

mm,

Diractor
Wzmlg

Enc.

l

M.

D.

�</text>
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                    <text>February 14, 1964
Dr. J. C. Holden
34, Green Lane
Burtonwood
Hr. Harrington

Lancashire,
England

Dear Dr. Holden:

have received excellent letters of reference, and I am pleased
to consider your appointment to the Missouri Institute of Psychiatry.

We

position of research psychiatrist carries with it clinical
and for this reason satisfactory completion of the
ECFMG examination is essential.
It is not possible, therefore, for

The

responsibility,

us to award such an appointment

However,

until that requirement is completed;

in view of your experience, I

would be pleased to have you

join the staff as a Research Fellow, to participate in the various
laboratory programs until such a time as you have completed the
ECFMG examination. This examination can be taken here in St. Louis,
as two members of the staff are doing this March.
An appointment as Research Fellow is available at a stipend of $900
per month. The stipend for your position as Research Scientist
(Psychiatry) will be at a minimum of $15,000 per annum.
During the past few months, Dr. Turan Itil, who is in charge of the
clinical neurOphysiology program at the Institute, has expressed an
interest in reviewing the post-lobotomy patients available to us in

the State services here. I am interested in the study in which you
are participating now, and would be pleased to learn more of the details of your present pregram.
I look forward to having you join our

staff.
Sincerely yours,

MF/jb
Enc. -

Max Fink,
Director
ECFMG

brochure

M.D.

�</text>
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mwww

”~7—

February 27. 1964

Dr. J. C. Roldan
34. Green Lane
Buttonwood

Hr. Harrington

Lancauhira,
England

Dear Dr. Holden:

This morning we roccivcd official notice from tha Duparcmcnt
of Santa that chase new forms are now to he used.

If

you have already submitted the earlier one. I would aug~
sent you call the Consul and axylain that you have the ltccut
torn and let him also: which to use.

Sincerely yours.
ﬂax Fink, Heb.

Diractor

MF/jb

Elle.

"

XIV. ESP-66

�</text>
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                    <text>March 16, 1964

Dr. J. C. Holden
36, Green Lane
Eurtonuood
Nr. Harrington
Lenoeehire, England
Dear Dr. Holden:

I should like to do my boot to reassure you regarding your credentials.
understand the record. you queliiy for this poeition, lacking only
full 307MB certificate. With thet qualification.
you ere eligible
for the position of Senior Research Scientist at the Institute.
and that
appointment will be effective on the date that you have eetiefeotorily
completed the ECFEG examination.
I
it
the

it would be helpful to have e copy of the
heve not eeked for that because I do not think it
in neeeeeery until the ECFMQ quelifioetion he: been eetiefied. I will
urge you, however. to bring your original oertiticete with you.
To

support that application,

D.P.H.

certificate. I

In my original letter, I indicated that housing is availeble heceuee the
hospital is located in the heart.of the city. One of the new eteff near
here. Dr.Doneld Sondlend, hoe rented a home about twelve minute: from the
hospital. Dr. Itil he: found e very fine home for rent at half of e twofeoily house. Dr. Gerebon he: rented an apartment at some distance from
the hospital, but has done-Io largely to be close to a
school
which his children attend. Dr. Reubnuer he: written to parochial
you about his eccounodetione.

If

you are planning to come before your family, we will try to set aside
zone space within the hospital for your accommodation during
the time
the: you try to find eooounodetione in the community. Unfortunately.
there are no epettmnnte at the hospital which would eatieiy your fouily’e

requirements.

'

I believe that ﬁts. Heubeuer would be able to
if you desire these to be made before

monity.

make

inquiries in the

you come.

oon~

I look forward to working closely with e Lenoeetrion. for I cannot recall
ever having had that pleasure before.
My

best regards.

MF/Jh

Sincerely youre,
“ax Fink,

Director

HOD.

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                    <text>April 10,

m. J.

196:;

C. HOldﬁn

30, Green Lane
Btmtonwood

Nr. Warringtm
Lancashire, England
Bun? Dr. Holden:

Psychiatric Research foundation of Missouri is
pleased to consider your request and suggest the following.
The Fomdation will make available the sun of $275.00, which
is the equivalent of the passage from London, England to
St. Louis, Missouri. In addition, the Foundation will be
willing to make a sun of up to $500.00 available as an
advance in salary-to help defray the oostséf transferrin
The

yoxm familyv

"

Enclosed are two sets of forms to which you should
attend. Please rim; two signed copies of each. In the
request for an advance, the sun is left open for you to fill
in the amount you wish, up to $500.00.
W33are looking

forum to

having you join us.
'
.

Sincerely yours ,
Max Fink, M. D.
Exemtive Director

141’:an

enc.

�</text>
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                    <text>October 8, l968
Dr.

J.

M.

C. Holden

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis. Missouri 63139
Dear Mike,
I have just read your laboratory data scale report to
the Amehican Jounuaz oé Psychiattg and reureed the butaperazine
study in the June issue of Cunnent Thenapeutte Redeaech.
Both are contributions to clinical drug evaluation programs.
and you should arouse considerable interest.

appreciate reprints of both reports. and would
ask in addition that you send me 6 extra copies of the AJP article.
I would

It

are able to read
the data sheets. and I anticipate that you will get some
inquiries. You should know that the MI? program does not
allow for the coding of drug and dosage - these must he added
by hand - and the range of values to be coded is not clear
from the printed form. The dependence on the instructions
leads to coding errors which are expensive to correct.
was kind

of you to indicate that

we

As improvements. we have recently reprinted the form.
making some additions and clarifications. It may be helpful
to send cepies of this form to the enquirers. and for this
purpose I am enclosing a supply. In addition, since you

wish to send copies of the outputs to some who are
interested, there are included samples for this purpose.
he are prepared to read both the HIP and the new form.

may

Keep up

the good work!
Sincerely yours.

'4'.

_,.~,.,

Fink. M.D.
Professor of Psychiatry

Max
I’vw-w-u-MW-rw,

I'V.7:VVW-W"r

at“;

MF:kp

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                    <text>nru-V.F.—mvm.-~

..

:‘v...

.

_.

wwwww.

wvmnmvwmq.mwv-wm.--..ww.,umm_.wmm.mmmwv-w.w._w.

my

w..- .,,..

W

.0. .7- . .‘v. "w...” ‘ -... m—w.
.V

20'. 1963

Home):
Hillsida M91131
no.

Max

Glen

‘

0m,

New Year):

:I amemlosingtho proof ofmdaftha articles‘

for

Valwm 111 Of the GIN? proceedings.“ Using
experim as a, basis, I am brazing 250
and rave requested Blaevier to smd you

far your use.

I

my past

Wecf
MMf

,

with covers
than;

‘

7

I

have not mwived the pmf of ﬁe. II:
Parfdrmmee befiles”.’ In the.
they are sent to you, I would appmciate yam
and camping sufficient mprints with «swam

"WWW

'

amt that
mating
to 63nd

m.
Q
m125for.wuae.‘
MWofwdshavehwnshippedvinRailway
Hillside
to
'

”mas,
five

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year attentim,

and

I

W

Hespital. Them am

they arrive safely.

'

Fink, M. D.
m
Water

24th

.m.

-.

W

V

.

�</text>
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                    <text>xvi"

-

'

"

‘

"N

'

“‘

"

‘

‘

'W‘VM-W‘W'W“

"'

:-

"‘V‘"NI

vwv

..‘

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.-

.

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N

,

March A, 1970

Koliday Inn

?.0. 3012317
Aspen, Colorado
Gentlemen:

_
_

w—wwmw

Vleusa cancel the reservation that I made for my
attendance at the Western EEG ski tastings. I regrnt the

inconvenience,; please assign my
as I will not be «bl: to attend.

room

:0 another atcandea,

V.“

,
‘
w

9
-

w‘nv-‘w-w

Thank you.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>July

30 , 1955

Dr. B. D. Holland

Associate Dimctor
Abbott Laboratories, Scientific Divisions
Department 0! Clinical Research
North Chicago, Illinois 6006M
Dear Dr. Hollmd:
have recently reviewed our clinical drug evaluation
could introduce an
pmgmm, and it is possible that we send
would
us some of the
additional oanpomd. If you
both the compomds
on
clinical mterial which is available
would review this
and
I
under considsmtim, my associates
in mid-September.
visit
have
you
and pemaps we cm mange to
the summr vacation
but
be
delay,
I regret that them has to thisweekend.
period begins for two of us this
We

call you
I would like to be able towhich
material
you
the
read
having
after

to us.

when
may

I return and

mks available

,

Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>December 22, 1955

Dr. B. D. Rolland

Associate Director

Abbott

laboratories. Scintific Divisions
'

Dopartnmt of Clinical

North Chicago,

Illinois

‘,..9 1'

M. ..

6005»

Dear Dr. Hollmd:

I have delayed marina yam letter of some months ago
regarding a Phase 2 stucw of A~107u9. This was occasiomd

lama}; because I have been in transition and have ﬂuently
aoocpted a position as Professor of Psychiatry at the New York
Hedioal College effective in June. If has, therefore, not
been possible to mdertake new smies during these many weeks.
As soon as the and of the present program is clearly
defined, I will submit the material of A—lo'lhs to my present
associate who may contact you when they are able to undertake

such

shﬂies.

monk you vexy much

for your interest.
Six-merely yours,

Pink, PM).
Professor of Psychiatry

Hm:

Hfzkp

�</text>
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                    <text>August 21, 1965

Dr. B. 1). Holland, Associate Director
Abbott laboratories, Scientific Divisions
Department of Clinical Research
North Chicago, Illinois 600614
Dear Dr . Holland:
Thank you very much him your description
Your suggestion that this oompomd be studied
of depmssives could not be fulfilled in this

of A-107n9.
in a group

Institution,

since we rarely admit patients with depressive illnesses.
Our population is primarily severe mentally ill.

If there is mason to mdartake a study in a group of
anemia, withdrawn patients, I will pmsent this material
to my associates for- their oonsidomtion .
Sinoemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>' aqum
xii-fig“

yr

‘
K%;&gt;

s1

w
-mx\W
5‘?

44‘

December 2, 1963

Aln,gg;L

Dr. Audrey R. Hollidqy
Departmnt of Pharmacology

School of Medicine
malt}: Scimous Building
ministry of Hashim

SW19

5,

Wmhingtm

Boar Dr. 301.11de:

Mlelhmmwwminmtodinthepmbm

of the intemctim of drum and personality variables, most of

wwmkinthis mahubowwithmlatimtoemtmahodp

effects ofMywmm,
11mm mmlaim m to alter the Mommies].
mum of the central
system, in a fuhim not too
diffamnt than dmg therapy. With this modal. I would be will-

ithmbemwemtsntimﬁutﬂm

therapy.

mm

ingtoimludoﬁnaffom efixmgedemvulsimasmtype

new

of bi‘odamical mange of the
system in any review of
the rumination of brain chemistry and personality variables.
Ifyouwish to midst-13119, I shallbc gladtosmdmereprints marked in the Maud publimtim list.
The

mfomm

mm
Musing update
drug therapy are

Ihnvc

“that my

intmst

you with

mgam to
I am

#5, so, 57. 86, 67, 75, and 78.
from this group that are available.

fit intome
littlcmwwmﬁwtmld
Iwmldmwmd,lmam,

qutimxtﬁupmsmﬁm.
that
you write to Dr. Max mm and m. In 301mm, my foxmr
associates, who have continued with the amlyaos of the
Hillsidn Bospital data. Dr. Polka: can be mailed at Hillside

trim

�W

Dr. [many R.
Page

the

2,

mum

1963

Hospital. and Dr. Bolmnt at the Dew-tum of Rehabilitation . Albert
Einstein collage of Hedieim. Bram, Haw York.

Wmvcrymmh forymrinquizy.
Sincerely yours.
Max

Pink.

War
Wmlg

m.

8

M.

D.

�</text>
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                    <text>.mj

~.

was”

.,,,~

V."

ly'w)’_:.n‘ em. .

w"

T.

.

.V... pm—.

V...“—

,“_m_,_,

:‘mrlc&lt;.u

. ,. ..~a—.

.......e...

Wyn—w."

July 20, 1971
Dr. Richard Hollins, Ph.D.

University of Oregon
Eugene, Oregon
Dear Dr.

Hollins,

Cyclazocine is the compound which has the most application

are more interested in 'pure' antagonists like
Cyclazocine is not in short supply,
but the other compounds are, as they are derived from thebaine
which is a compound on a government proscribed list.
Any efforts that can be xpended to improve the synthesis of
today, but

we

naloxone and

M—SOSO.

naloxone should be helpful.

a,
.v
v.

“Wiwﬂ'

efforts at increasing the duration
compounds
in man. The principal shortcoming
these
of
of action
of
the
antagonists is their short
of the therapeutic use
we
and
to have a formulation that
were
duration of action,
would be effective for 30 or more days, the clinical problems
of opiate depnendence would be easier to treat.
I would suggest you contact Prof. Paul Blachly at the
University of Oregon School of Medicine, as your most local
authority in opiate dependence. He has an extensive experience
in addiction research and a keen understanding of the role of
the antagonists.
Equally important are

Good

luck.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

,4-

v
3-.

V.

�</text>
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                    <text>April 9, 1962
Dr. Leo Hollister
V.A. Hospital

Palo Alto, Calif.

Dear Leo:
No,

the outline form is not better! Thanks for your
If we had more such, we might read them.
the way, how can one treat “about four patients”

chatty report.
By

(nialamide)?
I agree with your views of "long acting" preparations.
We had tested the spansule chlorpromazine and
compazine
against their respective tablets, and found better drug
dosage control and fewer "side effects" with the plain

tablet

(and cheaper as

well!).

I vote for a newsletter!
Sincerely yours,
MFzgp

ﬂax FInE, M.D.

�</text>
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                    <text>(I

June a, 1963
11‘. Leo

Hollister

Associate Chief of Staff

Veterams Achinismtim tbspital
3801 Junipem Serra Blvd.

Pain Alto. California

marina:
I

am

It was a plasma ta

show you around

gainful for a copy of the picture that

the Institute.
sent me.

you

hummupastfwmekslhambemasmdmt

again, and devote many hours to the intricacies of a new devil.
The water is a fascinating mgimering product but requires
a degree of mantras: which social scientists, like
ordinarily 1301:. If nothing else, I believe that commuters
will replace latin as a, tmining device for the minds of young
and as such. will. probably become the bane cf their
stance.
a331mm,

muss.

-

Simmly yours.
Max

Khan

Fink,

Meter
.

H. 1).

�</text>
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a".

Leo

K

Hollister

Associate Chief of Staff

Veterans ministration Hospital
Palo Alto, Califonu‘a

Dearlao:

ImplaningtomtotheECIEUmtingamOctobers—u.
make
reservation for me at the

ask your secretary to
a
motel closest to the hospital for these two nights and hold for
late arrival. (I probably will be arriving in San Francisco on
M Flight #177). I will, of course, gmmntee the reservation.

Would you

Looking fonm'd to seeing you.

Many

thanks.

Sincerely yours,

Mfzaw

Fink,
m
Director

MO

Do

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                    <text>Number 29,

Dr. Lao

1965

Helium

Associate Grief of Staff
Veterans
Hoepital
Palo Alto. California

mutatim

Dew Leo:

Refemee has recently been trade to the Side Effeats Scale
whidxyauhavemede available formVAStudy Program Would

ymplemsendmneepy,orindieetewhm ithasbean
publiaMd?

My thanks.
Sincerely ywm,
Fink, 11.1).
m
meessor of Psychiatry

'

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                    <text>ﬁnd: 1,

Dr.

lee

1*k'.’2l.1l.i.stcle~

WW

Associate Quiet of Staff
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1966

Fele Alto. Galifomie

Hospital

Mien,
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memmPaydmphemlogy," toetMthmethodsofmG

mm
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drug

since 198»
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analyzers were applied to

eeeeeemte. Beaver, the principal feces
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W

leeplaeedtomcloeeecewefemmualdeseribing
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the wplieetione

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smarter text presented at the W113:
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in October is also enclosed. this
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IBM

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M with our progress.
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Hex

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�</text>
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Donna,

Whamafﬂnminiodhbmmm

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mum,
Wm of Wm

Max Firm, PM).

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                    <text>'June 5, 1967

HOllister
Associate Chief of Staff

'Dr‘ Leo

-

Veterans Administration Hospital

Palo Alto, California

of'
‘

DearLeo,
As you can

see fmn the enclosed carbon,

I find myself

more

in agreement with those you have criticized than with your own
position. It is sad, that even now, five years after the initial

meetings of the Camittee m: Clinical Drug. Evaluatim, we have so
few strong investigating teams for early clinioal drug work and
that the models are still, almost exclusively, based on clinical
miter'ia. .The pioneer
of Lehmann in attempting to use
psychological tests, the interest 'of Itil and myself in EEG, the
biocmmiosl investigations of Denber, are but a few of the
alternate approaches in man which my, hopefully, provide better
bases for detemination of chug patterns. But I must feel, with
Arthm‘ and the others, that yam criticism ref the few units that
are doing the hard and serious exploration, was largely unjustified,
and, as you can see fmn my letterhif they are willing to delete the
ad homénen mimosa which do wane any good, then perhaps the
-

‘

wk

dialogue will be useful.

It is

always a pleasure

to argue

with you.

Sincerely yams,
Fink,
Professor

Max

Pﬁzkp

M.D.

of Psychiatry

�</text>
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                    <text>September 28. l967
Dr. Leo

Hollister

Associate Chief of Staff
Veterans Administration Hosﬁital
Palo Alto, California
Dear Leo,

to take this opportunity to thank you for your
my associate, Dr. Jovan Simeon. He has returned
from his visit to California quite enthusiastic about the work
in your laboratory.
I want

hospitality to

recently been asked to consider a study with
I recall that some years ago you were quite
enthusiastic about this drug and I would be grateful for
any reports that you may have prepared in your studies.
I have

oxypertine.
Many

thanks.
Sincerely yours,
ﬂax Fink. M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>i
5

L

Hovomber

Dr. Leo

8, l967

Hollister

Veterans Administration Hospital
Palo Alto. California 94304

Dearvtoo,
I read your report on ST? in the latest issue of Science
with great interest. Since the first reports that chlorpromazino
ur—nwi

accentuated the clinical effects of STP. it was apparent that. if
these reports were true, then STP must be more similar to Ditran
and atropine than to LSD and moseoline. Your report clarifies the
apparent discrepancy between the pharmacological data in the press
and the statements from the FDA.

.vyrrmw-r

(if

pm

ow.

raw

WWI"

armmuvmw

cw

esoecially interested in using
and important discrimination.
YoUr report in Science notes that EEG records were done prior to
drug administration. More these repeated during the drug period?
If so, were the changes consistent with any of our reports of EEG
changes with anticholinergic and sympathomimetic hallucinogens?
Incidentally, thank you for your comments on Oxypertino.«
I
If can get some for EEG trials, I will surely lot you know
what we find.
our

I am

EEG

writing because

methods in

we

were

this difficult

Sincerely yours,
wva-ap-wmvxwya-nur-u-r-WWV

Fink, $25.9.
Professor of Psychiatry

{t‘ax
wy-vr-w-u-vw

HF : kp

m—m‘JP"

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                    <text>7383—83283
20 December 1973

Gerald L. Klerman,

M.D.

Superintendent
Erich Lindemann Mental Health Center

.

._

.....

Government Center
Boston, Massachusetts 0211h

.

"w...“

Dear Gerry:

V...”

MW...

but

I

was

of your Committee at the FDA
especially pleased to read the write~up in Psychiatric

have heard of the work

I found the missions of the Committee of considerable
interest because the present methods of affecting change in
regulatory policy do not allow fer a regularized input from
news.

the academic community.

In this regard, I am taking the liberty of sending you
cepies of letters I sent to the FDA. These is much concern
with prdblems of drug equivalence and bioavailsbility. EEG
measures to record the central effects of psychoactive drugs

and studies done in this laboratory and similar laboratories
in St. Louis, Basel, and Goteborg provide optimism that these
techniques may be useful in answering questions to which blood
level measurements are now applied.

Should it be within the purview of the Committee, perhaps
you could consider a review of the ayaiaable data with an eye

to undertaking collaborative studies.
My

best regards for a successful

new

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

Encl.

L

a.”

,,

512‘

~

‘
3

,v

,

,

,

“$34-41,:

- i

.1

;... sillnnl i

�</text>
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                    <text>73619-4 70A?

16

Milton Gambian.
V.A. Boopital

Hoveﬁbor 1973

24.1}.

Sepulvcda, California 91363

Re:

Dear H112:

665/116. 10/26/73

Thank you for your daacription of the Paul Book Award.
baliove
the paragraph apall out an approach which is comI
nondahla and which I will auppott at the forthcoming Council
mung.- shots“ it b. poaaiblo, I would ha grateful if you
would attend the Council meeting so that this morondua can
be mda a nutter of Association rooorday
Many

thanka

for

your recommendation.

Sincerely youra ,
Max

PIP/(:13

Fink,

14.1).

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                    <text>7383*778AP
16 November 1973

J.

R.

Wittenborn. Fh.D., Prasidont

American College of Heuropsyohopharmacalogy

Intcrdinciplinary Research Center

Rutgers Univuraity
Brunswick, Row Jersey 08903

How

Dear Dick:

First, I want to thank you for your cooperation in raw
solving the issue of my invitation to Dr. Bonk Van Riozcn.
I hnvu road you: memorandum of Novanbar 6, and I an
writing to respond to this. The issue» strike on: the
bylaws and present policies of the fellowship; and the nnnd
v~ns pictured by Councilw-for additional inconn.

.w

-

-

TJLW“§IU"H’"'W‘WW

Vmﬁt

".va

'ijﬁl'".

7’”r:’w'

In the early yaars of the ACHP, when it was decided to
hoop the wasting: small. tho 3ellowa votod to limit the nun—
ber of nodbers. and in snooooding your: rantrictad the invi~
cation of sonata to one per Follow. I cannot recall, and in
checking the bylaws cannot find, any stipulation as to who
may be invited. The assumption has always boon that the Pal“
low inviting a goon: would do so for the purpose of expanding
the participation in tho activitioa at the ousting. For cx~
topic. I havu invited co~workorn as sonata when I thought that
'ihayocoold contribute to the sessions or when I thought it
would help thoit education. I have also invited proopactivo
numbers. and in the past your: invited foreign collaborating
aoiqntists because I have vinhcd to encourage a broads: pnt~
ticipntion by the Fellows and laboratotios not represented
in this country. Indeed. Torah Itil, Martin ﬁsts. and I have
carriad this mission to for that no have invited 1 number of

toroixn scientists who how: no affiliation in this country
to participato in on‘gghhg§_nnoting nan: month.

�J.

R. Wittenbotg_

~2¢

'16 Novomber 1973

In this regard, I boliovo it is an undue assumption of
authority for the ﬁectotary, the Pro-ident, or even the Coun~
oil to rejoct an invitation extendod by 3 Follow. whether
Follows should or should not invite snout: to tho 1974 matting
could be toilod next month. If the docioion is made that
sonata are to be invited, it is clearly oath FelloWéo prth
logo to invito whomnvot he planets. and i would hope the Fo1~
laws would not dnlogoto a voto pout: to any officer or to
Council, but would trust tho good judgnont of each Follow.

issue, that of the need of tho Ann? for ad—
ditional funds, is one that should bu diocualed by the Council
and tho followohip next month. I think it is donooning for tho
ACE? to not a quota or levy a tax on industry. should tho ans?
really nood funds for niooions that are in the public interact,
a description of the miouion, a call to the fﬁllowohip with a
oonourroot latter cont through the followohip to indultry,
would probably bring a voluntary reopens. consistent with the
on. to Which the funds would be out. A: it is now, neither
the fellowship not industry has been presented with a clan:
otatoment as to how the funds are Spout. True, there is a
financial report at oath ﬂoating, but this is gloosod over.
Indeed! my tooollection is that the AER? has almost $50,000
iniita trouury. (At the lat nation, I won stmek by the
oboorvntion that tho ACE? was tho secondwrichest organisation
to which I bolong.)
In driving to work yontorday warning, I listened to o
toplay of the Sonata Watergate hanrings. in which tho.Prosi—
dent of Anorioan Airlines indicated the prostate that Mr.
Hixon's lawyer! placed on induotty. Rofleoting on his a:—
ooeintos sad thoir ottionn. I felt those to be immoral, if
not illogol. To what extent would a policy of a molti~thou~
sand-dollar tutti! {or industry to participate in on odocnw
tionol «noting such as out: be tonsiderod of borderlino moth
The oooond

._

..

.
.

.‘.,.,.,.

{“1"

o

,W-‘,._.Hlm.um.

A...

..

2'11""

ality?
I an

to discuss tho policy of abstaing high moor
berohip foe: to 0.8. industry rootstontntivoo. I should like

the Councilla vicwo.to be discusood by tho fellowship with the
viaw that the policy be changed. I holiove that the ASH? will
be on titan: othical and fionocial grounds it participation in
the auctions is separated from the inane: of fund raising add
expenditures.
.

Sincerely yours,

.""

'-

Wluixnwrr:w=rvx’v‘r

Max

';

rink.

M.D.

Protoaoor of Payohintry

V"

.pz‘mwwvw

pnoporod

Hr/tis

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                    <text>May

23. 1964

Dr. Lee E. Hollinter

Associate Chief of Staff

Veterans Administration Hospital
3801 Junipero Serra Boulevard

Palo Alto, California

Deer Leo:
Thank you for sending me the article on LSD. we have recently
begun some studies with LSD here, and suddenly the eaten: and
some of the other professional people have become alerted and
have asked for some diseualion of the pans of this compound.

Here, for the past year. we have been using such potent agents
as hitren. Sernil, and a variety of other exotic compounds and
nobody seemed rhe least bit interested!

I

am enclosing a final copy of our report on chlorpromazine
and imdprnmine, and only tell you that we have sent
to the

Archives for

it

their consideration;

I would like to see your report, as I have already heard it
quoted by the repreeentativen of a pharmaceutical house. Your
press in most active!
Sincerely yours,
Max

rink,

Director

mm»
Enc{

H. D.

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                    <text>July 3, 19M

Loo B.

Holllstor,

H. D.

Associata Chic! of staff
Votarhos Administration Hospital
3801 Junlporo Sarto Boulavard
Palo Alto, California
_

Dear Lao:

I have been playing with Dvorall'a programs and havo recently
determined the diagnosis of our patients using his idoallrod
olooolftoatloo. An I recall, in one of your papers you have

daacribod a uaa of tho cooputor oathods for detcrmioins the
amount and/or type of thongs occurring in patients. If I reoolloct correctly, you oood this oothod in your evaluation of
baorqolnanldo.

I would to grateful for a copy of any paper. preliminary re~
port or a abort dcsctlption from you of your present method:
at using the IHPS classifications for change score purposes.
In raadlng the inipramino~thlortdozino paper. I see that you

uaad tho computer program for clonslfication only. Did you
drop the 103 of patiants whore diagnoses were not confirmed
by tho cooputor nothod?
Hy

boot ragarda.
Sincerely yours,
Fink,
Director

Max

Hrljb

M.

D.

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                    <text>February 17. 1965

Leo E. ﬂout-tor, um.
Antoni-t0 Chic! of Staff
Veterans Administrition Hospital
3801 Juulporo ﬂirt: Bouluvard
P110 Alto, Californtn

nu:-

un:
now

he:

I hm jun: «in the “(trance to m articla an ch. trut—
«at: schizoyhunte
:riﬂupcxtdol. We an
”that: with
And
own
would be grateful if
our
«sportsman.
I
“much:
of

you could
Ky

uh I par-print

available to no.

but: regards.
minutely your: ,
Ha: “Bk;

Elﬁn

14.1).

Profuse: of Psychiatry
,

�</text>
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                    <text>March 12, 1965

Dr. Lac 3.

Rollistat.

H.D.

Aasoalato chief of Staff
Vetcran: Administration Hospital
3301 Junipero Serrn Blvd.
Pale Alta, California 9&amp;306
Dear Lac:
Thank you {or sharing your paper an

trlpcrldol.

My

associates

and

slaca our findings are not as
I found in quite interacting, elpeclally
strongly supportiva of triperldol in our schizophrtnlca.

extrcnaly hulpful insofar as when we rcvluwud
had none that fit ch. sob»
our Ichlzophroalc group. we found that up runlly
diagnosis." Ht chackaa this
group a! paranoid schizophrtnla an a ”para”13 thts'thc lira: tits 3 computc:
wlth tn. Overall program on our ratings. A.honpltal? Vary helpful!
profllc was rolgtad to rasultn in a non—
Rawevnr, your notns wart

'

in
associaton. Dz. Roldan. attendcd the VA Hunting:
on your panel
31w Orlcanu. a. rtportid to our stuﬁy group ycstcrday
in patlonta
finding:
o!
cyc
1n
ch.
ruparta
and was vary Inch internstpd
vatk.
the
past
in
we
will.
As
a connoqunncl,
rnealvlng chlorldnsinn.
:ccelvlng
study
group
qpcelul
unﬂain
a
who
at.
ehodk all tho patients
thlorldaslnc. and will plnn'tc do so over the naxt unny annthn.
Anothar of

My

my

-

bad: rogardl.
Sluccrcly yourx.

,

,

/

,

,,

an: rink,

'

M.D.

'Profonsor of Psychiatry

�</text>
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                    <text>July

16 , 1965

«an,

W'Fzspw‘rmvw.

'

gammy-qr

‘l'

a

.«mm

.

Dr. loo E. Hollistsr, M.D.
Associate Chief of Staff
Veterans Administration: Hospital
3801

Jmipero Sam Blvd.

Palo Alto,
4

'
A

vauyymu‘wua

“W75

KETW‘R-ﬂ'kwwsﬁ'

EM"!

Califmﬁs

9&amp;30'4

merino:
chronic sdmizophmnic: patients with
butmmine, we have recently noticed an unusual complication .
'Ihis patient has developed room‘mm: episodes of severe polydipsia
and polyuris which appear to be mlstsd to the developmnt of
other symptoms of parkinsonism. The ochninistmtion of pmoyclidins
seem to msliomte the parkinsm syndronn and to alter the polydipsia
and polym'ia.
In trusting one of

01m

your intsmst in adverse drug reactions, I thought I
this am with you, and ask your midmos in the
study of this phemna. An: you man: of this mactim with
Knowing

bmﬁtilf

'4,.TWWIWW‘Z"

..

‘~

mule! share

phemthiazims?

‘

We are madsrtaking another sm‘ndmsntal period with this boy,
will do the usual urinary and blood studies including momma
of osmlsrity, which our oomultmts may distinguish psychogenic

and

polydipsia from diabetes insipidus .

kind,
If you have any oitatims referring to pmbloss of this
you may wish
would be gmtsful for them as well as any

I
mots
toma‘kesboutthis case. I antakingtm libertyofsondingyou
a short om study and a graph of our meant observations, which
my be of intsmst.
My best regards.

Sinosmly yours ,
«r

~1x~zrrmwr“~'m:"

Was-r

rmzeur

ﬂax Fink, NJ).

Professor of Psychiatry

�</text>
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                    <text>7w;-

Wm'lﬁxaumr

-:r.

July 6,

1967

Dr. 130 E. Iblliaster

Associate Chief of Staff
Veterans Administration Hospital
3801 Junipem Serra Blvd.
Palo Alto, California 91430.

'

Dear Leo,

It would

indeed be an honor

to have the data of the

HER

studies included in your forthconing review. Separately, I am
sending sane reprints which span the past decade as well as
three discussions which sumarize the Host recent views, and,
a pmprint of the outputer appmaches which interest us presently.
While I do not think that the last is mlevmt, perhaps the
direction

would be

'

of particular interest to you.

to this subject,
but
three separate
reviews of this very large problem in response to different requests
sent to me in the past six months. In cash review I am taking a
different tack. Perhaps I cOuld write a few paragraphs as the basis
for inelusion in your report if you would pose the questions which
know how much space you wish to devote
perhaps you would like to kilow that I am miting

I

do

not

face you.

subject is of deep interest and mutant, and I snuld be
willing to assist in as
a presentation of the present
knowledge as I am able, if you mm but feel free to ask.
The

mm

Incidentally, I muld be pleased to receive a preprint of your
it has been accepted by the editors .1

vam-

review after
My
&gt;

best regards.
'
.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

-

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                    <text>March 7, l968

Dr. Lee E.

Hollister

Associate Chief of Staff
Veterans Administration Hospital
3801 Junipero Serra Blvd.
Palo Alto. California 94304
Dear Leo.

.

While I have more than a half dozen reports that are
waiting to be done, I am stimulated to accept your invitation
to write a summary of EEG and drugs for practicing physicians.
I would rather not give you a date because I am sure I cannot
meet it, but I am sure I will attend to this at the earliest
date I can.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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,.

.

....

-"'.1‘ n.

n;

February 6. l968
Dr. Leo E.

Hollister

Associate Chief of Staff
Veterans Administration Hospital
380l Junipero Serra Blvd.
Palo Alto, California 94308
Dear Leo,
Dr. Henry

Elliott

has invited the review of

human psychopharmacology and I am very

EEG

and

grateful for your

recommendation. In preparation for the ACNP meeting I
did complete the review until early summer l967, but I
will continue with the literature and trust that it will be
as useful as your reviews have been.
Again,

my

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>December 2, l968
,,
:1

Dr. Lee

mw-mm—z

Hollister'

Hospital
Palo Alto. California 94304
V. A.

.

Dear Leo.

t

wwmvw—

Enclosed is a draft copy of the presentation for
Pharmacology far Physicians. 1 have tried ta make it less technical,
and feel that I may have succeeded in the second half only. It
represents the synthesis of the work of tha past decada from many
laboratories and while I believe it to be true and accurate, there

is

much

that will raise

some eyebrows.

If there are portiohs that are unclear. or changes

mm

«

w

wish to make. please feel free to suggest them Or,
please sand on to Dr. Madell.

you would

if acceptable.

van-y.

n
vwl

Many thanks for the invitation and the Opportunity to
reformulate these thoughts.

Sincerely yours,

awt'an-uvrwvmrp—xwmuzn-uv—wmuc—n‘

Max
I

‘V'JIGX'CS

-

u
M

‘mw‘d'

mam

'-

.mxmr'rwmw’mnwmﬁwwmﬂmw7.

mum—w

.v‘fm-yﬁ

mf/

Fink,

H.D.

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                    <text>Match 27. 1972

0:.

Leo E.

Hollistor

Veterans Administration Hospital
3801 Eiranda Avenuo

Palo Alto, California 94304
Dear Leo:

the cannabis oynpooiun
will be plotted to participate in We
1972.
will provide an
of tho 813? in Copanhagon. August 17,
We

abstract
in

to be provided

on the forms

by Dr. Jacobson.

can prepare a printnready manuscript for Copenhagen.
August within space limitations you may suggest.
We

to than.

As

Dru. Stefania and Hires. I have soot your questions
Thoy should answer you shortly.

for

For tho

listing,

our presentation should be

"Behavioral and

EEG

TXIC"A"9" o

titled:

Effects of ﬁaxijuana and

mxﬂm,&amp;m,LVdmh,mm,quMWMMPmm.
M.D.
M.
Frooéman.

and A.

Department of Psychiatry,

title
list:

The

you

York Hodicol Collego

and co-authora of the Stofanis«ﬁiro3 prosontation

should be deforrod.
may

ﬂow

Provisionally (subject to thoir approval),

"Studios of Chtooic Hashish Users"
Costa: Stefania, M.D.,

A.

Liakoo. M.D.,

Costco Miran, H.D., and Mn: Fink,

University of Athens Ind

Row

Md).

J. Boulougoris.

York Modiool Collage

M.D..

�Dr. Leo E. £10111:th

March 27, 1972

I look forward to this interesting session.
Sincorcly your! .
Max

Fink.

24.1).

Frofenor of Psychiatry

14ng

�</text>
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                    <text>,,

...

.
w...“

‘qu.an

1-. ‘

.vmmmmtwmmawwanmw—uw

February 7, 1972

Dr. Leo E.

Holliater

Hedical Investigator
Veterans Administration Hospital
3801 Junipero Serra Blvd.
Palo Alto, California 94304

-/v-A

ur—wv-W—w—u—w‘

Dear Lao:

studies of cannabis are proceeding in chronic and
acute trials in volunteers in New York and in studies of long term
hashish users in Greece.
Our

The ﬂew York

studies are focused

on the behavioral. memory,

and SEC effects of different doses of sacked marijuana, both in
single dose studies and 21-day chronic studies. The data define
the central EEG effects, bear direct dose relationships, and show
some evidence of tolerance development. These data could be pre—
sented as "EEG and Behavioral Effects of Marijuana", by Pink, M.,
Volavka, J. and Dornbush, R.
we have examined 35
we are now comparing

In Greece

subjects

who have used neon-

the effects of seeking hash~
years,
THC~8-9,
and ganja (Jamaica) on beish (Greek), marijuana. (U.8.),
havior, EEG, heart rate, and performance tasks. These data could
be presented by Dre. C. Stefanie or C. Miras - "Long Term Effects
of Hashish Use" by C. Stefania, C. iiiraa, R. Dorcbuah, J. Volsvka,

ish for

and

M.

+25

Fink.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>r

5--

Wmn mum-v-

"uh-w,z-L'yvvrgw—W/vn'!wxrmmrrw.

V

,

,

uu

mmwm

w'

-

\

'.,,_

catcher

_

,

25%h, 1972

m’rm‘

.v.

A!

Br.

Lea E.

Kalli-tar.

lod1aul tartat1gntor,

Veterans Adl1n13tra31on Kosp1tnl,
3801

3

.

911a

lirnndn Ar...
Alto. Cultforniu 9haoh.

Dot: Lou.
Tho report nubn1tted ta the CIIP 1s A nunnnry of two
ruporta 1n grass. and sun. additional 111; b¢1ns prepnrcd 1n
arsc$or 1.1111. Thu yﬁbliuhoé reverts and 1n press include:
21*Duy

Administr1tion of usr1au131'1n Male

voluntlern. Cunaent Reilaﬁch in Maaijaana, pp.

115*128, 1972. (Dornbuah, B.L., Clnre. 6., Zaka.
Crown, P.. v¢11111. J; and Fink. M1)

/«

1.,
_

,

‘
I
'

le1juann, EEG and Bahtvior.’ In: M3r13uanaz
Chemistry, Phsrmneology, and Patterns of Social
U... A. Singer 1nd 3.‘Yollen (319.). Ann. N.V.
A114. 311., 191: 206—215, 1971. (Voliwkn, J1,
Dornhunh, 3., feldstein. 8., Clare, 6., ana.

rmmx.mdhuuu.1)

ltfootl of

:

1.,

9-tc1rnhynroegnanh1no1 on E26. Eunrt

ante. and “bod. Etcctnacuaeph. Olin Henaophgazat.
5:: us: (abstrnat). lgvz. (Vbluwtn. 3., norahuah,
3.. Poldntuia, 8‘, and Pink, H.)
The vultvks

ruyort, abntraetad 1a 336 el1n. Neurophysiol.
to Payuhophsrunaolngia.

has bocn suhn1tt-d

my bait rncurdn and «aﬂtrntultt1ont
to the 19!? presidency.

on your nomination

a1nncroly ynura,

ﬂux r1nk.

“.9.

9rofusno: or Payeh1atry
“7/13

WI-‘wn-‘v:nun-n

�</text>
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                    <text>Im—W”

September 26, 1972

Leo E.

Bollieter,

M.D.

Medical Investigator
Veterana Adainietration Hospital
3801 Miranda Avenue

Palo Alto, California 94304
Dear Leo;

013?.

Enclosed ia a short summary of our presentation at the

flying with one of your claaamatee, Arthur Schwartz
weekend. Did you know he haa built hia own amphibian,
has temerity to fly it? Indeed, I watched him! He aende hie

I
this past
and

was

regards.

I red! your report,

and

that of the other participants,

to the Deer Lodge Conference. While the consensus supported the
visual behavioral and aynpton aspects of teating new paychotera—
of cerebral
peutic drugs, no mention was made of the measurement
as patients.
volunteers
in
effects as indiceo, which may be ea uaeful
are reaponaible in large measure for our failure to
communicate but the data of EEG claaaification studies of paycho~
reaponaea
active drugs ia really more exciting than the washed-out
some
methods
require
newer
Of
the
course,
quoted in the symposium.
be
to
recording,
egg.
rigorous attention to drug, dose, netting,
unless one is
preciae ~ control: that are difficult to achieve
with
careful. For example, we have conaiatently found EEG changesbecause
cheervers
by
earlier
cannabis ~ changes uieaed, we believe,
of methodological problems. Anyway, we are not ea depressed about
atudiea of new drugs in volunteera - indeed, it in an exciting developeent.
I enjoyed the Copenhagen meeting. deny thanka.

I an aura

we

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

HF:ig
Enc.

�</text>
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                    <text>November 23, 1970

Dr. Leo E. Holliater
Veterans Administration Hospital
3801 Miranda Avenue

Palo Alto, California 94304
Dear Leo,

After cending you the abstract, ”Alert EEG Classification
of
Psychoactive Drugs", I reviewed the presentation and
believe the enclosed revision and new focus is more appropriate
to the Society.
New

Bioavailability is a principal concern when drugs are
role
prepared in new formulations. If the EEG has a specific
CNS
index
of
be
useful
an
effects,
as
in drug evaluation, it may
and as a measure of equivalence of dosages or dosage forms.

If possible, the enclosed abstract should substitute for

the one sent
Many

earlier.

thanks.
Sincerely yours,
Pink, ”.0.
Professor of Psychiatry

Max

MF:kt
one o

�</text>
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                    <text>January 29, 1971
Dear Leo,
I will be pleased to chair the session on CNS drugs
scheduled for Saturday, May 1; 1eaving up to you the feasibi1ity
of being in two locations at one time.
Many

,

thanks.
Sincerely yours,

“W4‘

“‘7'

wit-“*1

van-Wm.

m"?

'n
'

Max

Fink, H.D.

Professor of Psychiatry

�</text>
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                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
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            <name>Relation</name>
            <description>A related resource</description>
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                <text>The Max Fink Collection</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="46452">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>en-US</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>application/pdf</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text/>
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        <name>Correspondence</name>
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    </tagContainer>
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