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                    <text>~~u-. “7.5.”:

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1970

Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Wilma,
Our cﬂnlcal GP sludy is prOQrosslng well buf we are in
need of additional placebo supplies. May we ask for l0 x 50

placebo?

affached.

A-label for idenfificafion of our present supply is

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

MF:kp

\

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                    <text>E

E

.3

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1

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June l5, i970
Dr. Wilma Harrison

Geigy Pharmaceuticals
Ardsiey, New York
Dear Wilma,

Following our discussion of June i0, i am pleased to include
reports of our studies of GP 4l299. The clinical report,
dated June i, l970 (iV: 6-l0-70) summarizes the data to May l, I970
with supplements to June i. As we discussed, these clinical trials
will continue to the limit of the available supply of GP 4l299.
You indicated that IOOO additional capsules will be shipped, and we
two interim

estimate this to be sufficient to add

3

additional subjects.

will complete these trials during the next 8-l0 weeks and
submit, in September, a final report with the case records, Gelgy
report forms and laboratory summaries.
We

report (ll: 6-i5-70) describing
4i299. it is clear that the EEG profile,
at single 75 mg doses, ls readily distinguished from placebo and most
resembles the drug, doxepin. For a definitive bio-classification
study, i would recommend an oral EEG comparison against doxepln,
chlordlazepoxide, imlpramine and placebo.
am

i

the

EEG

also enclosing

classification of

an interim
GP

clinical trials in progress, we would also suggest
clinical trial of GP 4l299. i am pleased with the
present pilot data which indicates that 225~300 mg/day is well
tolerated, clinically effective and safe in our laboratory tests; and
that the target symptom is overt anxiety. From the EEG profile, i
would suggest that measures of depressive mood be added and patients
with manifest depression be included in the trial. A protocol for such
a clinical study will be prepared in September.
Based on the
a more definitive

i

trust these data are useful,

Your comments on

grateful for your cOOperation.'
these interim reports will be welcome.
and

i

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkf

enc.

interim reports

#2
#3

(iv: 6-i0~70iand

(ii:

6~l5-70)

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                    <text>r
..

mm“

“Hwywr

M

-

wvw-ucv'wr W. ”Minn-'M

,

r'

way-rm:n .

3‘

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‘wm'm 'm—Ur 4mm? m:m.ww—nr

-

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s..ww‘wu‘m.

"WW4.

July 3, 1970
Dr. Vilma Harrison
Geigy Pharmaceuticals
Ardsley, New York

mm.

.

---Im‘-'Zv";r

Dear Wilma,

n‘

w:

As

I mentioned

on the phone,

I have

discussed the

willing, interested and able to evaluate the
list of clinicians
and
antianxiety effects of new compounds with some
antidepressant
and
with Dr. Stephen Bernstein of the ECDE'U program
associates
my
of
The
MIMI.
following
investigators should be considered for
of
an evaluation of GP 41399.
Schiele and Abussahab:
University of Minnesota
Cole, DiMascio, Schader:

Goldstein:
Rickels:
Merlis:
Klein, D.:

Boston State Hospital
University of Mimi

University of Pennsylvania
Central Islip State Hospital
Hillside Hospital

There must be others, but they do not come to mind in this
review. Occasionally, Hollister (V.A., Stanford) has taken on a new
compound; Sugerman has done some OPD studies at a private hospital in
New Jersey; and Gallant (Tulane U.) has reported on cmtidepreseant and

antianxiety
to

compounds

in alcoholics.

is anything
I trust this is helpful.
Ifonthere
me.
in
call
this
assist
venture, please
My

I

can do

best.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
mf/

.

,: m.wan—m ,r-wW

:s

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a. «Y w-l-

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                    <text>“w

w

A-

~

.w ‘~;“wV-Fw-vvmr

.v

rwwwn-u.wumAv'v‘ur’."

-

NNK‘VW"“¢ "Wm

~

an:

A.“

-w-- wnvrw'w-v

”-

‘

v“

"‘

"

‘-

r
‘.
"-v

run

September 28, 1970

-'~=v't

r.“

:1
«‘u

..

:c'

Dr. Wiles Harrison
Geigy Pharmaceuticals

Ardsley,

New York

-h’\r~'lw‘ﬂ’..5.m-

Dear Wilma,

91

A

2

cum;

I have read the two EEG studies of GP 41299 by Kales and
Denent with great interest. I have read of Kales' sleep studies
for a few years, but this is my first opportunity to directly
compare my techniques with his. Dement has not previously been

identified with

new drug

studies.

Both studies suggest that GP 41299 enhances REM activity a finding interpreted by Deuent as almost unique (see pg. 23).
Kales failed to elicit effects on REM at 50 or 100 mg doses.
Both Denent and Kales, for reasons that are not specified,
suggest studies in insomniacs. This recommendation does not
seen to be based on the study data, but on information which

is not clearly stated.

striking, in both studies, is the absence of statistical
sophistication in defining the drug induced EEG changes. I was
surprised by the small sample size, and the impressionistic nature
Most

of the

summary

statements.

I cannot determine the relation of this data to the alert
but I am most grateful
profile of GP 41299 as we defined
for the opportunity to examine these studies and to attempt such
a correlation. I find nothing in these data to be inconsistent
with our observations or conclusions, and would continue with our

it,

BEG

suggestions.
and

Again,
my

my

thanks for the change to read these two reports,

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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mwmu

-——m

nwmmmrtw‘vw-

“runs—"tum:

.—

Ayn-NV

Tmnn‘.»

October 21, 1970
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Wilma,

Enclosed is our "final“ report on the pilot 6? 41299 study,
and the Geigy ”Record of Treatment” forms for 12 patients. These

data are to replace our earlier interim reports.
We

anticipate the clinical

next month.

GP

41299 ~ placebo study, to

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

Mszt

start

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‘

4!“:
_

I!r“.;,"‘,./"';':’/

May 9, 1992
Wilma Harrison, M.D.
Roerig Division Pfizer Inc.
235 East 42 Street
New York City 10017-5755

Dear Wilma,
Thank you for the invitation to participate in the teaching commitments
am delighted to do so. As you know, am now identified with ECT
and catatonia than in standard antidepressant research. My ’expertise’ is rather
specialized and may, or may not, fit into the Roerig teaching program.
of Roerig.

I

I

ECT is a most effective treatment, which is offered mainly at major
academic hospitals in the U.S. It is hardly available at Veterans Hospitals, state
mental hospital, municipal hospitals mental health services, or the NIMH clinical
center. Despite the confirmed efficacy and safety of modern ECT. Despite the
reports of numerous commissions and study groups. Despite the belief by many
psychopharmacologists that the drugs can do all, for all, if only their knowledge
and skills were applied. [Even Don Klein, however, has begun to refer patients
for ECT.]

What can be done?
ECT, can surely help.

If

you wish to support lectures or conferences on

I

Perhaps Roerig is interested in something more. Each year at the
APA, the industry sponsors large lectures, with food and excellent P.R. Each
year, the topics are focussed on drug treatment for mania or panic disorder or
therapy resistant schizophrenia, each a topic designed to support a defined use
of a specific drug. Roerig could do more. Offer a symposium on the evaluation
and treatment of the severe mentally ill, with a focus on the relative efficacy,
indications, and combined uses of drugs and ECT. By including ECT, you will
capture a large [and growing] group of physicians who feel that their training
has been deficient [it generally has] and who are now asked to use ECT [by

insurers]. A symposium could be organized about a single diagnostic group
[depression, bipolar disorder, psychosis] or about a problem [treatments in
pregnancy, the elderly, or young adults] with a focus on guidelines for the use
of drugs and ECT, in association or sequentially.

�Wilma Harrison, MD.

Page 2

Catatonia is a second topic. A few years ago, Mickey Taylor and
wrote an argument that catatonia should be separated from schizophrenia [it is
only defined as a subtype of schizophrenia in D-SM-lll] into a separate class in
DSM-IV. The DSM-IV committee agreed, in part, and now recommend that
catatonia be a modifier of four conditions.
I

Our interest in catatonia is based on two issues. ls catatonia a part of
schizophrenia or is it something else? Considering the particular efficacy of
ECT, should it not be separated from other conditions so that ECT can be used
early in the treatment? Further, are catatonia and NMS similar or different

disorders?

also enclose an editorial “Pharmacotherapy and ECT” which
expresses my opinion of some present lacks in the education of
psychopharmacologists and clinicians about ECT.
I

Some specific suggestions. For lectures, the following titles are
descriptive:
For whom should ECT be considered?
ECT and pharmacotherapy: Combined and sequential use.
Efficacy and safety of modified ECT.

Catatonia and NMS: Identification and treatment.
Catatonia: Not so rare and very treatable.
For the APA, a conference can be organized on the topic of catatonia, or
therapy resistant depression [psychosis], or the pregnant psychotic. Each topic
can be organized to be rather unique in modern APA annals.
I

enclose some reprints for your review, and a copy of my ’short’ c.v.

My

thanks foryour consideration and my best regards.
Sincerely yours,
Max Fink, MD.
Professor of Psychiatry

�</text>
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                  <elementText elementTextId="101634">
                    <text>July 2k,

Horthwotn
Dopnrtann: of Physiology

Mr.

Am

1964

M.

_

and Pharmacology

University at East Attica
Rnirobi. Knnya
Kant

Attica

not: Mr. Earthworn:
Mr. R. N. Lindsay, of tho Allociated Press in Johannsaburg.
has reintrod no to you for information rogarding the now
tranquilisor, M99.

writton to Mr. Lindsay after reading an article in
a local nowsplpor rogurdids tho use of this drug to subdue
a rhinoeoros.

we

had

‘

The

ea"

r."

.

Missouri Institute of Payohiacry is a research

cantor.
ond one of our mnjo: progrlma is the evaluation of new
psychotropic drugs, which in part of a national early
clinical drug evaluation progrlm. Uh would greatly
approciaco rocoiving any iniormation available on M99,
especially the manufacturor‘a anus and address.
Thank you

for your cooperation.
Sincerely yours,

.

A.-

~A

A

M“ Fink.
Director

”V'.”

IJb

M. D.

�</text>
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                    <text>July 20, 1971
Dear Ernie,

progress has been steady with the Seminars, and
the only handicap is the summer holidays and the fact that
my secretary has joined her husband in Texas.
The

Four reports are in; two more are promised by the end
of the month; some of the Q&amp;A are in, and others have yet
to be completed. I plan to have my editing done during the
first few weeks of August, and the reports will be retyped
by my secretary in Texas. This may cause some delay but her
accuracy and judgment are indispendable to me.
what

I

There are two hold-outs as of today, and I shall see
can do

this

week.

I will send you

some

manuscripts by

mid—August, and

remainder should meet an early September deadline. Should
you wish to edit the texts then, I would be grateful.
My

thanks for your regards.

Sincerely yours,
x."

min

.7:

Max

'1';

:1

'1.va

w

.

Fink,M.D.

the

�</text>
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                  <elementText elementTextId="106774">
                    <text>7383~846SB

27 December 1973

Joseph Thane, H.D.
Research Division

Boocgp

State Hoepitol
Street

S91 Horton

Bolton, Massachuoette 02126
Dear Joe:

I on writing to recommend Mien Carolyn Poinier, who is
interested in continuing her education in Boston
end any oall
you for advice as to a position en a research eeeiotent. 8h.
gredueted Colby College with excellent grades
June. 1972,
and he. boon with me these pee: 18 months. Sheinhas
pated in the work of this laboretoty folly, includingparticirecord~
in; of BIG. proceooins of EEG vain; the Inn 1800, otatiotioel
analyse: and beheviotel oveluetione luring human experimentsall of those in male volunteers.
-

She

is en attractive

girl with enthusiasm
that io'unmntched by any of the leuy young
people who have
worked for on. She is reliable end deyendable. and
I recon—
oend her highly.
Should ohe

cell, I

end ohaxuing

would be

give her for openings the:
broaden her experience.
may

1974.

M3

beet pereonel regard:

grateful for any advice you
utilize he: colonte or

may

end

best wieheo for a healthy
Sinoorely yours,
Fink. H.D.
Professor of Psychiatry
Hex

MF/oie

P.S.-I

hove

sent the

some

letter to Ernie

Bertmenn.

�</text>
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                    <text>August 9, 1972

David S. Haskell, M.D.

Senior Psychiatrist

The Commonwealth

of Massachusetts

Department of Mental Health
591 Horton

Street

Boston State Hospital
BostOn, Massachusetts 02124
Dear Dr. Haskell:

be in

fer

I will be in Europe until August 21.

On my

return, I will

York and can meet with you on any Tuesday or Friday. I pre8/22, 3/25, or 8/29 as in September I will have additional comNew

mittments.

Please call my secretary at 212-369-7900 (ext. 245) - let
plan to come, (10 a.m. at 5 East 102nd Street, 8th

me know when you
Floor, Room 33).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

iﬂhig

�</text>
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Miss Jo Hawkins
Associate Director

Rush Research Foundation

9201 Sunset Bled.
Los Angeles,

California

90069

Dear Miss Hawkins:
I have checked my files and find neither a letter to
Dr. Grinker nor a letter stating that I have made such a

request.

Enclosed
Dr. Brinker.

is

a

letter

which I have

Just sent to

Sincerely yours .

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Jam 24.

1969

Mss Jo Hawkins
Associats Mmtor

Rush Rosssrch Foundation
9201 Sunset ma.
Los Angaiss, California 90069
Dear

um

Hawkins:

I have checked av ﬁles and ﬁnd author a letter to
Brinks!- nor a latter stating that I have made such a
roquss .
Dr.

Dr.

Enclosad 1s a

Maker.

letur

which I have Just sent to
Sinosro‘ly yours .

Has

Huh. ".0.

Professor of Psychiatry

�</text>
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                    <text>:1

inwnv-«marﬁ

1-va

“run.

r

bin-ah 15, 1970

Hr. David ﬁgyden
81310! Editor

sextant Hausa
Raw fork Clay
Ema: Mr. ﬁaydﬁn,

I have read the valunu, €2in£aal ﬁandbaok af‘Psyaho~
phanmaaalagy, adxtad by Diwunaia aaﬁ shudar, with grant interact.In samurai, tha aaaciena are well written, nuthazitativu sné typrsoant
the grcvmillng apinion a! ch: leﬁdurt xn psychaphuraaaolcuy as
unually oxyraaaed in mattingw and writinga.
r

mmwe'rm‘mw:

vv

¥her¢ is and seating. hgwavur. whiah in proacncad
to gently as to dqatwuy ch; vulva a: aha valumn for am. Enfartunately,
I tn partieulatly intcroqtﬁé in and identiftaa with neurophysiology
of psychoactivu ﬁrugg. Tbs aaatian by Miruky is too poo! to be
acccytqblc to m¢, and my gppravnl of tha rust of the Voluma
(which I mania gladly give) may ha migtakmn as my apprawal for
this cactiun as well.

‘1‘3N‘R-

Thank yam

warm-r3157,-

publieacian.

my

{at the opportunity ta cea thia

Ea»: wiuhna ﬁat

its

Vulumn

hater:

aaeoptaaes. ﬁespiae 1:9 flaw.

‘1
~

V

Kinccraly yearn,

-mvlm"éwsiwvt".=w¢

.9123

Fink, H.n.
Profaaaor at Psydhintxy

Max

W'Eemmxw

mywsm

W552“.

4-.

aura”

m

‘
1-

~mwm

mmwyﬁmrm

uf/

�</text>
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                    <text>habrnary 5, 1974
Book vac Riezon, M.D.
N.V. Organon

Oas, Holland

Dear Bank,
We

have been notified by the

FDA

that the use of the

placebo formulation in the study of 01-63 and placebo should
be discontinued, until they have had a chance to evaluate the

placebo.

I have called and discussed this modoege with Joyce.
indicates that she has used the material in two instances.
Rather than wait for a decision from the FDA, she indicated
that the study could proceed as wall with normal saline. She
believes that the data will remain valid, that the evaluators
will not be in a position to see either injection, and that
she could procacd with saline.
She

I agreed.
soon

you.

I trust that this judgement meets with your approval.
as I have heard further from the FDA, I will write to
my

best regards.
Sincerely yours,
MAX

Fink,

M.D.

As

�</text>
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                    <text>20 March 1974

313 Bun: Duvalopncnt Company
P. O. Box 597
Stuamboac springs, Colorado 80‘7?

Genclauan:

I van undblc to atunnd tho Winter Confarqnun on Brain Emu
my rnsatvauion after paying a d¢p¢ait of
$50.00. I anticipated rtfund of this #09031: but havu not yet
racoivnd one. I balievn my cancallatiou was and: in dun tin».
search ana caudalled
Thank you

for your nttantion in this matter.
Biuearaly yearn,
Fink, 3.9.
Profassor of Psychiatry

Max

Mrlcia

�</text>
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                    <text>W!" 22, 1965
His: Viola P. Hwhumt
Bar Harbor, Hum 0&amp;809

Bur Miss Hayhmt:

Mmfwymhmrofinquhymganﬂmapoaitim

inpsycmpharucoloyinthuc laboratories.

xmwmm

MW. ImmttomeMley

muiﬁuofoﬁuratdfmmmmmpomibloform

natavdlnbleforﬁuappoinmmtofmympoaitmmmingm
nextfwmths.

-

Smmlmmllmmmngmm

v-wrr

humtinﬁxislmntorymmlamdtoitslmtimun
St. Louis)
Iwould
its
ortc

whasismpsydmptmmloy,

likmtellywﬂutﬂnmfwwhichlhmbm
mpmalbh will probably be curtailed wring 1966. imofw as
itimashufumofl‘sydiiatryatﬂm
Ihmnmptedﬁn,
Medial Col
inJmo. I look
establishing aimilar‘ studies mm,
labomtary director, Dr. R. Roy Jam, has mllmt facilities
andlbolimﬁmthomigrtbointemtodinmmlwith

1’on
31:11thth

Howl’oxk

'

your qmlifiotdzma.

If you an

automated in the poulbilitics in

Now

York,

dimlytohimatthﬂow‘fork
mlsmtﬂmmmw
York City).
helical Galley (106th 8mm: and 6th Amm,
New

Simly your-a.
Hm:

Fink, ".13.

Professor of Psychiatry

�</text>
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                    <text>April 28, 1965

Mr. Robert Ham
Smith. Kline- 8 French Laboratories
1500 Spring Garden Street
miladelphia, Pa. 19101

mar ﬁr.
Mr.

Haynes

Wt.

Zwahlenwaekindenoughtosendmofthe

I
reports fm the Science Infomatim
fwnd these met helpful. especially thme relating to
EEG menses in animals..
I m apologeticfor having intermpted your day
all about sum refemnm which
could not find in our files. It m helpful talking

earlier this mek so

_

we

to you.

Thank you very

web for your help.

Sincerely,
Max
.

MP

:jm

Pink.

M. D.

Professor of Psyd'xiatry

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                    <text>4:345”

May 11 ,

Marguerite T. Hays, M.D.
Medical Research Service

1976

V.A.

Washington, D.C. 20h20

Re:

M.

.

David

Fairchild,

Ph.D.

Dear Dr. Hays,

his co-workers

I cannot eecall meeting

Don Genden

and Dr.

Dr.

Mickey——

Fairchild, but I

the

latter

have met
serving as an

ad hoc reviewer of one of my NIMH grant applications. I do know their
work well, and have followed
will interest. They first published about
1969, declaring that the effects of drugs on the EEG of cats could be

it

distinguished using multivariate statistics, particularly that they
could identify different drugs by this method. Tley proceeded to
extend their work with a predictive study and were successful. Since then,
they have published occasionally, and I am not acquainted with any systematic
body of data or systematic applications.
Their work was unusually well detailed; their statistics
was exemplary; and they held a promise for greater applications, particularly
in studies in man. The reports reflected peofessional knowledge of EEG
recording and

statistics.
It is difficult for

me to parcel out the contributions of
therefore to assert what Dr. Fairchild'd
unique, personal contributions may have been. If a number of his reprints
were made available or brought to my attention, I could possibly evaluate

each of the

them in the

participants,

and

light of the developments during the past decade.
I

trust these

comments

are responsive.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

‘

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                    <text>m

r.» r-T”
7

-

..-,m. Wmmws

. -WW~—r-.wsm—wmvn‘wu-w
,

.

.

.

n.-

v

guru.

\

I'a-W'VW

....

v-vI-K

wwv»

April 5, 1978

E

Margarito T. Hays, H.D.
Medical Research Service
Veterans Administration
Washington, D.C. 2ou20
Dear Dr. Hays,
work

of

I

am

pleased to respond to your invitation to assess the
is being considered for an appointment

Dr. Larry Squire, who

as a Research Career Scientist.

;

My association with Dr.
Squire began about four
ago when I noted his reports on the effects of BCT on memory.years
heard him speak at Rockefeller University and at the Winter I
for Brain Research, and then joined him on a panel on ECT at Conference
the Society
for Neuroscience. On each of these occasions, I learned much and
was
impressed with his knowledge of brain function and memory. When asked
fer recommendations for a panel being organized NIMH assess the
status of ECT, I recommended Larry and he becamebya paneltomember.
Later,
when asked to recommend a scientific
consultant to the Task Force on
Convulsive Therapy of the American Psychiatric Association, I
again
recommended Larry. In both positions I have worked
with
him, and shared
the task of assessing the effects of seizures on brain function.

wwwuum'w

.n

.
a:

“vuwum

Tm."

'

~w.-M“

~urzr

Dr. Squire was trained at H.I.T. with my former
teacher,
Hans Lukas Teuber —- a critical thinker and
I
teacher.
believe
Larry learned much there, and came away with a keen

Prof.

problem of memory,

its retention

interest in the

its loss. I think it is to his
studies
and

individual credit (since such
were not in Dr.
repertoire) that he saw the merit in examining memory Teuber's
and
amnesia in the one reversible paradigm in man which is functiond
ethical
to
examine, that of convulsive therapy where amnesia is a
regular
of the treatment. Further, since the amnesia is reversible, Dr. feature
quire
had the advantage of examining its development and
in the
its
recovery,
same patient, within a time span of weeks to months
-- surely finite
enough to be credible.
The techniques for the study of
function in ECT are
the standard psychological paradigms. Since memory
became interested in
Larry
the long term effects of BCT, he developed novel
of memory based
on TV exposure during different decades. His teststests novel
and
are
sensitive, and have become accepted not only in ECT research, but seemingly
in

�——~

v4.4---m—wr

.—.,

.m—r

«umnw r—‘W‘r—“mzxw:

-

wur

.

.i—n-

m.VWW——rmrwmmmwﬂwom

W,

.v... nwn ~

2.

studigs of

memory

in drug assessment and neurosurgical interventions.

While most of his emphasis in the past few years has been
in the EC? process, I think his interest is broader, in the memory
process itself. To this end, he has undertaken studies of amnesia
fellowing surgery, trauma, and in systematic studies in animal
experiments. His work has consistently been well designed, carefully
done, statistically sound, and with the most reasonable controls. His
evaluation of the differences between unilateral and bilateral ECT
are among the most compelling new data in this field, and his assessment was an important feature of the recommendation by the APA
Task Force that unilateral ECT be considered the primary mode of treatment in depressive illnesses.

I believe his work to be sound.

skill to deal

He

has shown the necessary

attracted bright young
clinicians,
researchers to his laboratory. My assessment is best expressed by
the fact that when the Long Island Research Institute, a research
arm of this Department of Psychiatry, was seeking young talent fer
its staff, I recommended him highly and sought him out. Unfortunathly,
Long Island did not seem as attractive as Southern California. Nevertheless, my offer remains.
with

and he has

His work at the APA TAsk Force and the NIHH evaluation
to have good political skills. His presentations were well
documented, and I have every reason to be pleased with my
show him

recommendations.

While he is young in years (37), his experience since his
doctorate (1968), and his record of publications and presentations
support the recommendation for his appointment as an Associate
Professor.

I

am

pleased to

recommend him

to you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

W mm..mw
W

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                    <text>W
Public than}:
Division of

28, 196i:

Sonia

mm Grants

untimallnatitutos of Health

B e‘thoada

1n, Maryland

Dear Sim:
would appreciate receiving six of the new
form for applieatima of the
mtg as soon as
possible.
We

mm

‘

Sincenly yum,

m,
Dir-m

Max

an]:

14.1).

�</text>
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                    <text>Homer ‘5,

W

196-3

Baalth
Facilities Branch
Division Of Rascmh Facilities
and Romans:
Natiomsl Institutes of
Bottnsda 11), Maryland
Gentleman:

Hulth

W"

He: FR 08087

‘

of a letter nooivad from that Chief
of Flaming and Construction of the State of Missouri mgarding
‘moloscd

the West

Wing

is a

protooopy

Laboratories.

In line with this favorable bid, which in good for 90 days,
«closing revised page: of this applioatim. In addition
the following
to inserting than mviud pages, would you
item?

I

am

mat

»

Fag.

l.

Fag. 7,

#2. 9mm“:

Mutated .. $122,071

- Total - $196,770
min.
iC.3.b. Amtdtoots' Foes:

Pay: 7. 98.3.c.

-

‘(hvioo to

mm

* Pug: 7,

10%

$19,677

Total Oonatmtim cost estimate $216,“?

mum
mm: mum}:

of Chief of Planing)

ate; $2“ 1’47
for
in
this
application 122,077
Fag. SJEJwTotal mutated
Sine-ray yum,

Page

9,!E.7.-Total

Max
m-‘zaw

one.

Fink,

Director

M.

D.

�</text>
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                    <text>7483~05883
1 Fabruary 1974

Paul Kinlholz. M.D.
Profnsoor of Psychiatry
Psychiatrisohc Univornicﬂtoklinik Banal
4056 Basal
Wilholm~xloin-8trnﬁe 27
SWITZERLAKD

Door Poul:

should bu possible for Dr. Gastpnr to work with us this
coming summer. Most of our work in dovotod to the recording
and onnlylis of tho 226. Hi havo no oxpertiso in can or roo~
piration. There are, howovor. soiontioco on this campus who
are wall known (Bernard Inrcky and Milton Lodge). and thoy night
be willing to have Dr. Gaotpar visit. From my oxporionco hora.
I boliavo he might be interested in spending time with Dr. Ax
in Detroit. for he has a fine reputation in poychophyoiology.

It

Should Dr. Gnltpnx be intornstod in working born, I oug~
tell no sonothing about his experience and who:
ho would like to nchiovo in a visit homo. If I can, I will
respond by suggesting tho kind of work that would haip him and

soot that ho

ho

consistent with the
Thank you

work

in the laboratory.

for thinking of us.

My

boot rosardo,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

H31

MF/cia

�</text>
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                    <text>7483~014SB

10 January 1974

U. S.

Burnau

nap-trunnt of Junkie.

at Narcottan

Bangorous Drug.

and

Wishinstou, D.C. 20507
Gontlonnn:

I

hnvn ruc01v¢d your

with n label angle-ad.

luctnr rusardinz an

A3308

entry

Etfcctiwu Jnnnnry 1. 1973. I discontinund operations
transfurrod eh: rcsponnibiltty {or work
It that location radRichard
Raanick. M.D.. at tho stun rd—
in that program to
argon.

Sincorcly yours,

“.3 Fiﬂk.

Md).

Professor of Puyehintry

MF/cil

Incl.

�</text>
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                    <text>June 1a, 1965

Department

of Hulth,

Food md 0mg

Matias,

Adainistmtim

and Walfam

Hashingtm,VD.C. 2020i:

anm 0. Kelsey, NJ).

Attantim:

m‘m.

‘

i

RE: IND 26M)
'

money:

m

This in tn'admewlndge manipt of
letur of Jun 10,
IND 26W, mwing tho clinical investigatim
using the dmg Scmyl (CL-395). "this is to indicate that the
following inmtigatom are participating in the study Lamar
w] aupcrvisim, and thair unrivalm vita: an enclosed:
1965

mm
.

'

Turin Itil, NJ).
Ali manor. 14.9.
John C. Roldan, M.R.C.P.

Alexandar Dun, 11.3.8.6?»

will amply with the mgulatims submitted and the
«‘1 page two of your lattw cumming
progress uports.

mm
-

V.

merym formusistm.

81:10:me yours,

ﬂax Firk, NJ).
Professor- of Psydxiatxy

�</text>
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                    <text>May

Richard Phillipson,

M.

10, 197h

D.

National Institute of Drug Abuse
Rockwell Building
llho Rockville Pike
Rockville, Maryland 20852
Dear Dick:

I could not help overbearing your recommendation of a
candidate for residency to Jon Cole during the Anxiolytic meeting.
K

As I am writing to some friends describing a fellowship in
this Department which has Just been created, it occurred to me that
you might have other friends from England vho write to you looking
for opportunities in the States. I am taking the liberty of send~
ins you a copy of a memorandum which deacribes the opportunity.
Should you have a candidate whom you may care to recommend, I will

be grateful for your recommendation.
My

best regards.
Sincerely yours,
Me: Pink,

MF:ed

Enclosure

M.

D.

Professor of Psychiatry

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                    <text>.
&lt;
-

July 07, 1970

wﬂ'm""-‘

A,

.
.v

-v~'."!va14

Hearing Clerk
D. H.E.W.

Fisher’s

5600

Lane
Rockville, Maryland

”raw-1tma

Re: Methadone Regs, Proposed

Sir:

Dear

I am writing in response to the proposed regulations
”Conditions
for the Investigational Use of Methadone". Since
entitled,
1965, this laboratory and Department have been involved in studies of
methadone maintenance and other forms of narcotic antagonism (cyclazocine,
naloxone). I believe the exclusions listed, namely peegnancy, psychosis,
physical disease and age less than 18 are too restrictive, and possibly
illogical. I would suggest that these exclusions not be written in the

regulations.

'

The treatment of pregnant women is a logical step in
the methadone maineenance programs. After all, who is in more need of
help out of the sordid drug addiction cycle than mothers ? We do
not know whether methadone is safe and surely every effort should be

to investigate this application.

made
lﬂ’m'l'cmrwtwﬂ'w‘ﬂrw"

effects in
seems

Psychosis

some

be helped by methadone, which has antipsychotic
and such a study should he encouraged. Again, it

may

reports,

illogical to restrict this medication, if it is indeed helpful,

to healthy addicts only.

.rnwrmrr-n-r.

squash-F“qu

.

applies to serious physical disease. We have
successfully treated a number of older patients with eveidence of
cardiovascular disease and methadone may have heen life-saving in these
subjects. Rather than restrict the studies, I would encourage these
The same

trials

as

are to

we

particularly helpful.
If one restricts methadone to persons over 18, what treatments
offer the younger addict ? What is the magic of '18' ? While

it

would be unfortunate to start younger persons on
one may agree that
a life of addiction to methadone, is the same not true for an older person

the

These
and

artificial

restrictions are illogical to

puritanical

me, and may represent
views of the authors of this regulation,

little experience with treatment of opiate
dependent subjects with methadone. If they had, the regulations would
reflect an expression of the need for these studies, rather than their

who, I suspect, may have had

exclusion.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.......

as. ......_ ...

?

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                    <text>September 30, 1964
Dr. Robert Heath
Professor, Dept. of Psychiatry
Tulane University School of Medicine

Orleans, Louisiana

New

Dear Bob:

First, let

A.P.A. which

that session.

me

congratulate you on your program for the

I think is

an

excellent

one and

I look forward to

Dr. William Lang, a phermacologist in our
laboratory, is
some holidays in New Orleans next week. He
is participating
in Dr. Gershon's studies of the relationship of behavioral
changes
and various physiological variables
dé'they
modified
are
by
psychoactive compounds. I would appreciate his having an new
tunity to visit in your laboratories. particularly to see oppor—
the kind
of implanted electrodes and
cannulae you are using in your animal
studies. I have asked Dr. Lang to
and I would be grateful if one of call your office on October 5th
your associates could accommodate
him

taking

during his

visit.

Sincerely yours,
Fink,
Director
Max

mills

C.C. Dr. Gershon

M.D.

�</text>
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                    <text>—-—-----.~

m-

Tm

.--

Wm". w-n-mmmn'w-W—

“urn—”up...

mv— .wuurm-vmaw—
—

,

www...

;w

mnmvwm‘w-

October 28, 196“
Dr. Robert

m

Professor, Department of Psychiatry
Tulm mimity School of Medicine

New

Orleans, Lmaieiana

DearBob:

Dr.

I

to take this opportunity to thank you
many canteeiee that you and your aesociateo
Galbraith, extended to Mr. Willim Lang daring his

for the

want

visitwithyoulastweek. Hecanebaokfrmhie tow

mach encouraged with the pharmacological and psychiatric
work that he had sea: and I anticipate an encouraging

response in his work.

in Santa Fe, Dr. Brazier
presented a paper damnetreting that the frequency spectral
chmgee in scalp electrodes paralleled the production of
During the SH; meetings

apikesinelectmdeeinteupoml Wmmm

The

figures indicated that in patients with considerable alpha
activity on the surface, there was a decrease in the amount

ofalphaandanincreaeeinboﬁathethetaandbetabandev

a broadening of the spectnm of frequencies - which was
interpreted as e surface sign of spikes occurring, in the
depth. The figures resembled the spectre]. dmges seer: with
intrevenom imiprmine eo remarkably that I have taken the
liberty of sending copies of my figures to her. In your
patimte with various depth electrodes, have you had the
oocaeim to minister indpraaine? If so, is it possible
for one of your weietmte to check whether spike activity

ieiMucedandwhwe,mdwhethe theatmfacemoordeehow
While the question may
this desynohmnization
be a bit irregular, I hope you will underetmd that those of
us who have found their work limited to surface electrodes
are always interested in any expression of correlations be-

twemthedepthandtheeurfecewhichmybehelpfulintm
interpretation of our obeemtims.

04/

�-2—-

13‘.

WM
Again.

my

October 28. 1963

my

m

best personal regards.

for your my

Mains md

Sincerely yams .
Pink, 14.))
m
Director
.

mf/ls

�</text>
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                    <text>October 28, 196“
Dr. Robert Heath
Professor, Department of Psychiatry
mlme University School of Medicine
New

Orleans, Louisima

DearBob:

Iwanttotbkeﬁiisopportmdtytothmﬂcyou

for the many coumzesies that you and your associates
Dr. Galbraith.extendedtoﬂr-.Williamlmxgdtminghis
.

Hecmebackfrmhistom
visitwithyoulastweﬂ
with
the
plmnaoologial and psydxietr'ic
m.
mrkthethehadseenandlmticipateanencoureging
,.

e

respmseinhiswoﬂc.
'

MingthemmetingsinSmta

Fe, DmBrazier

dmstxeting that the frequency spectral
in
electrodes
paralleled the productim of
dunges scalp
spikes in electrodes in tumoral regions in mm. 'me
figmes indicated that in patients with considemble alpha

presented a paper

wtivitymthe sm‘face,therewesadecreaseinthemmt

ofalphamdsnincreaseinboﬂmﬂxeﬁxetamdbetabands—
a broadening of the spec-tum of frequencies

--

which was

interpretmesasm‘feoesigiofspﬂcesocomringinthe

depth. “me figpmes resembled the spectral changes seen with
intravenous indpremine so renarkably that E have taken the

libertycfsendingoopiesofngfigmostoher. Inyour.

patients with various depth electrodes, have you had the
occasion to administer imiprmine? If so, is it possible
for one of your assistmts to check whether spike activity

is inducedandwhem, mdwhethe the swface

records

show

this desyndmronizatim phenomem While the question may
be a bit irregular. I hope you will understand that those of
uswhohave foundtheirwozk limitedtosxmface electrodes
are always intmted in any eicpmesim of correlations be-

Wthedepthandthesurfecewhichmaybemmfulinthe
interpretation of our observations.

�-2-

October 28,

19614

Dr. Robert Heath
Again,

my

my

thanks foryourmany oourtesiea and

best persmal regards.

Sincerely yours ,
Max

Fink,

Director

Inf/18

M. D.

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                    <text>3%;
September 25, 1978
Robert

G.

Professor

Heath, M.D.
&amp;

Chairman

Tulane university School of Medicine

New

Orleans, La.

70122

Dear Bdb,
Thank you for sending me a copy of the preprint describing
recent
findings in primates smoking marijuana, and the kind
your
comments on the 1961 discussion of your work. I thought then, and

still

most

believe, that you and your associates
original and intrepid investigators in

then are

still

the

same

today.

have been among the
America. My kind views

However, in some issues, the data that you present is
inconsistent with those produced by other observers and the
source of the inconsistency has to be found. I have stated in
the past, and still believe, that the principal findings of the
toxicity of cannabis smoking is to be found in examinations of
the users. They, alone, have the experience from which we can derive

a

realistic estimate of toxicity.

artificial

The smoking by primates, under
conditions can, at best, provide clues as to what systems

should be examined.

I have dedicated six years of effort to examine the effects
of cannabis in volunteers in New York and chronic users in Athens.
My experience is extensive, probably as extensive as any of the
younger invetigators writing today, and as I wrote in a number of
reports, including the final section of the volume Hashish- Studies
of’Longhterm 033, published by Raven Press. I commend the section
to you for the best opinion that I have on the subject.
As your

letter reflects, the issue is

no longer one of

fact or science, but of emotion and politics. I regret that you have
seen fit to allow your name and work to be used in the public press
and that you have sought to enjoin in public argument. I have not
followed this road, as you well know.
Indeed, I have stopped my

work in cannabis since leaving the New York Medical College (1973).

�Robert

Heahh, M.D.

G.

controls

.......

September 25, 1978

.......

page 2

I have read your report and remain unconvinced. What
for the readings in these monkeys ? Is there

do you have

a population of monkeys that have smoked tobacco under the same
conditions ? That seems to me to be an obvious control. Another,

what of monkeys that have smoked THC free material ? If the
slides are mixed between control monkeys and those exposed to
cannabis, what is the frequency of identification that an
observer can make of the effects that you cite as the result of
cannabis smoking 7 What evidence is there from studies in man

of these findings

of

some

you.

?

In any case, I am honored that you think my opinion is
It is kind of you to send me the reports and I thank

merit.

As a matter of record, I have spent the past few years
reviewing my studies of ECT and have Just written an extensive
review of the problem, which will be published by Raven Press
of New York in January as convulsive Therapy: Theory and Practice.

In reviewing the extensive literature and assessing the data,

it

has been possible to develop a reasonable theory of the mode of
action of ECT; It is clear that this major treatment is an analog
of pharmacotherapy and that its action is not dependent on any of
the physical elements of the treatment but purely on the biochemical
changes induced in the brain. It has been a surprise to me that the
leaders of the Society of Biological Psychiatry and other august
societies have shunned this treatment. I have learned much from
the assessment and I hope that you will have a chance to look at

the volume

when

My

it

appears.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Jdne 25. 1968
Dr. L. G. Beinensnn

Max

Planck

Institute

Bunsenstrssse 10
34 Gottingen. Germany

Deer Dr. Heinesenn:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Madrid. we have written s number of others
describing our 836 programs and I an enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is e need for groeter communication
among the few workers interested in this type of analysis.
The programs which we use. those of period. power spectral

density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the Inn
360 and should be easily usesble in the Control nets
series of instruments. If you have a programmer who is
interested in obtaining e copy of the print-out. we will

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky end
cornetzky. both at the Division of Psychiatry. Boston
University School of Medicine. Boston. usssechusetts.
seems

�Dr. Beinsssnn

~2-

June 25, 1968

While there is some decresse otItrevel
Europe and the United States. I an sure that
of my laboratory will be in Eurupe this yes:
In the event we have an opportunity to visit

between
some

usibers

again.

West Germany.

may be useful to arrange a discussion in Gottingen
it
slninize the communication difficulties 01 letters.

work.

My

best regards and congratulations on your fine
Sincerely yours.
Mex

Fink. n.n.

Professor of Psydhiatry

HFskp

to

�</text>
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                    <text>Jdne 25. 1968
Dr. L. G. Heinenann
ﬂax Planck Institute

Bunsenstresee 10

34

Gottingen. Germany

Dear Dr. Heinemann:

I must apologize for this tardy reply to your
interesting letter and your reprints. Since our
report in Hadrid, we have written a number of others
describing our EEG programs and I am enclosing reprints
of these as they have recently been published.
The examples given are quite simple and do not
do justice to the power of the analysis system. As
you indicate. there is a need for greater communication

among

the

few

workers interested in this type of analysis.

those of period, power spectral
density. and amplitude analyses are available now for the
IBM 1800. This program is readily adaptable for the IBM
360 and should be easily useable in the control Data
series of instruments. If you have a programmer who is
interested in obtaining a cepy of the print-out, we will

The programs which we use,

supply one.

In this country, the best work of the kind that
to interest you is undertaken by Drs. Mirsky and
Cornetzky. both at the Division of Psychiatry, Boston
University School of Medicine, Boston. Hassechusetts.
seems

�-2-

Dr. Heineaann

June 25. 1968

While there is some decrease of travel between
Europe and the United States. I am sure that some members
of my laboratory will be in Europe this year again.
In the event we have an opportunity to visit West Germany.
it may be useful to arrange a discussion in Gottingen to
minimize the communication difficulties of letters.
work .

My

best regards

and

congratulations on your fine
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mszp

�</text>
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My 23, 1936

W
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Mains, Sammy
Dear Dr. Heixmich:

Iwiahmmwuforymmkindimitmmtoattmdm

As you W, ﬁlms unable to
Swimm Pschmpnhology
atmhutlmmtcful forymrmmmmesa.
Have almmmiwdymrmyrmimmmwlmof
deal of interest
earlier promedings. I have mad this with a

mat
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mdlmtﬂmkbomymmw.
a ”Mass of atmiies which, I believe, will make a major contributim
to our Wading of tho ammonia promos.
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mmxtsimlffmymtomtotmmmsmagdn,l
wouldbeplamdhahwymviaitminmymlmatimim
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SW15! mm,
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                    <text>,‘m..rw-,rw-r “quvmwm.”my. Ar.w.w’.m.v,

v

.

;',-r.-«~

-mv=m.w~vgpuwmwrw.mv

y w» Vn'w-‘WI'TM‘V—I“Nun-"1

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T's—

June 14, 1971
Dr. Jon Heiser

U. S. Naval

Dear Dr. Heiser:

It was kind of you to bring your experiences with
physostignine to my attention. I had read your report and
congratulate your industry in reviewing the world literature.
"in

W"

Hospital

Oakland, California 94627

When we

worked with Ditran and

atropine,

Itil

and I were

impressed that the interaction of these drugs with chlorpromazine
was indeed dangerous, and sought unsuccessfhlly to make THA
available. But your suggestion of physostigmine is better.
I

trust

you

will continue this research after the navy.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

-

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                    <text>V'—" —.

V

r‘w

.W—q“..- .

mp7. '..'~mvlw"-u'.

~wr-1-

um‘ wwm www.mm... m.—_____.,.__

v... v .__.__v

v

We _

.¢_~W--W..VMMVV,_

20 September 1971

Dr. Jon Heiser
University of California

Irvine, California

Dear Dr. Heiser,

that

I

Your experiences are most interesting, and
you are extending your studies.

am

delighted

In our assessment of the EEG changes with anticholinergic
drugs, the changes in the theta/delta (2-7 cps) and the fast
beta (22-30 cps) were the most interesting. We used a conventional
frequency analyzer in our studies, and confirmed some of the
changes with our computer analyses using period analyses. But
many years earlier, the same work had been done very well by
Romano and Engel in 1944 (AMM Arch Nburol Phyohiat.,51:356-377)
using hand methods. Should these prove too painful or expensive,
and a frequency analyser unavailable, we would be willing to
cooperate, should you be able to collect the tapes necessary
for our analyses.
most important measure would, indeed, be the EKG and
heart rate, and these could also be analyzed using some of the
available computer processing methods. But they can also be
done by hand and eye.
A

I

am

not clear about the 'csrdiovascular toxicity of the
have not been too impressed with the cardiovascular

tricyclics'. I

effects of our compounds except for thioridazine, which does have
clearly defined effects on cardiac function, and is interdicted
on that score in my units.
Hickey

is busy planning an extensive set of studies,

I am delighted to have him back. Give my best to
John Kramer (should he return from his infatuation

and
Elliott and
with the W.H.)

Bank

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

W”

_W. _r_.-wee_.

.v—w ..

m v»

�</text>
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                    <text>W
X:

STATE UNIVERSITY OF NEW YORKVAT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

‘

EEG

Laboratory

Stony Brook, N. Y. 11794
Phone: 516-444-2447

'
.

December 2, 1976‘

Jon F. Heiser, M.D.
Asst. Adjunct Professor and
Asst. Chief, Adult Inpatient
University of California

&amp;

Emergency

Psychiatric Service

Medical Center
101 City Drive South
Orange, California 92668
Dear Jon:

While I am sanguine about my ability to identify projects
and issues which are currently of national significance, I am sorry if I

suggested that I could predict the behavior of national funding committees.

Such committees are now made up of representatives of the laity and
minority groups and no longer need be the best in our society, nor the
most rational. Hence, my hesitation in even suggesting that I (or any—
one) could predict their behavior, which often is formed by such issues
as geography, color, "old—boy syndrome", etc.

If you ask whether there are target issues of high
which should be fundable, try the following.
1)

patient to

How

can one

(a)
(b)
(c )

predict the responsive

priority

from non—responsive

antidepressants

lithium
EST

(How

to predict the end point of

EST)

to drug therapy? To
treated differently than men by psychiatrists? Are the distinctions justified by biology? If yes, by what biological differences?
EST?

Are women

2)

Do women

3)

What
What

respond differently than

is the efficacy

men

and safety of

MAOI?

In what conditions

is their relative merit against other treatments?
are these useful?
there any truth in the legendary statements of toxicity of MAOI?
.

(5

Is

any clues to a genotypic diagnosis (clafhfication)
system? For example, under what conditions does the sedative'threshold pre0
dict course and therapeutic result?
h)

Are

there

�Dr. Jon F. Heiser

December 2, 1976

Page 2

critical, general issues that could sustain
without
project
getting involved with technical issues of
chemistry or electrophysiology.

a research

These are some

'

Good

luck.
~Sincerely yours,‘

Max

MF:fg

Fink,

M.D.

�</text>
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                    <text>March 20, 1964

Dr.

Heistad
Wm T.
Luthemn College

Califmia

‘mcusand Oaks.

Califmﬁa

DearGwdm:

man:

you very

web for your

for
letter of mmndatim
vitae of

conmimlun with my associates.
m. Paul Mitch. I found hisdiscussed
and
haw
it
sidemble
At the want than, I am awaiting the arrival of a Japanese
mum-5781010318“ who is joining my staff on April 1. I

inmt

mldukamvmsentthemwmtohimandﬂmn,ifheconours. invite Hr.

Naiuoh

to visit our imtitute.

mnkywverymmfwmimwm,m110dcfomard

tosaaingyouatthenextECDEUmetinas.
Having just gone mmugh mothar 311mm!“ wintar, I an

seemgoodmasmmywhavedecidedmspendsm
in Oalifomia!
My

.

best mgards.

81ml); ycum.
Max
_

HF/jb

Fink,

Dimctor

Mal).

time

�</text>
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                    <text>‘rv—Iaw—vuwvmwrw-rr

'

rmww'aw's

October 6, 1969
Dr. Max Helfand
65

New

Central Park
York,

New

West
York

Dear Max,

Enclosed is a collection of reprints of studies completed
during the past many years. These are the basis for our present
study program in convulsive therapy. When you have had an
opportunity to read these please call my office.
I would appreciate your

returning this.
Sincerely yours,
Max

Fink,M.D.

Professor of Psychiatry

Mszp

ruwr-

mum-u

v-

mm

�</text>
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                    <text>n-nr-mwrmmw'mw'm'l' {Wm-

rut-s

.

'r'. .7.

»

.«V-"wm-x-«w-uw.“—._ .- 47...... 'uvuAHMTM “my—any“ «pm-pu-

0.

,-

v
-

.—

A.-.A

mirr‘xruva-w—U'T-vw'

October 6, 1969

.«

wﬂpvm—wm.

.r
,

.—¢-w&gt;‘-—K"-u"rwmr'fv

Dr. Max Holfand

65

New

Central Park
York,

New

West
York

Dear Max,

is a collection of reprints of studies completed
the
during
past many years. These are the basis for our present
study program in convulsive therapy. When you have had an
Opportunity to read thoso please call my office.
Enclosed

I would

appreciate your returning this.
Sincerely yours,
MEX

Fink 'MOD.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>or may YORK AT STONY BROOK
Health Sciences Center - School of Medicine
STATE UNIVERSITY

3’

3

’

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

April 27, 19773,

Bernardo Heller,

M.D.

2323 Van Buren Street
Apt. 201
Hollywood, Florida 33020
Dear Dr. Heller:
and

Institute

The

it

now

opened the ward L6 in the

has 10 patients in three studies.

fall of

1976
Dr. Asnis is

the ward chief, and Dr. Ts'o will be the other staff person
in July. As you may have read, N. Y. State did not allow
any new positions for LIRI for 1977-78; and so, regretfully,
I cannot process your re—application at this time.

It

training

would be best for you to complete your residency
and meet the requirements for licensure in Florida,

try to-re—establish your research studies.
Best wishes in your studies. I trust I will have

and then

chance to see you at one of the national meetings.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszg

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                    <text>December

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx.

New

York

Dear Leon.

discussed with you. I am enclosing a paper “Newborn
Sex Ratios Associated with Pre— and Post- Partum Process
Schizophrenia" written by Dr. Taylor who is one of our third
year residents. The problem is either a very important one.
as I think it is. or an interesting footnote.
As I

I would be pleased if you and Dr. Gallagher would read
and I would like to arrange an opportunity for us to
get together to discuss this further. Please call me as soon
as you have had a chance to read this report.

this

The report has been submitted to Science and until it
has been accepted for publication. I would ask you to use your

greatest discretion in discussing this report.
Sincerely yours.

Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>ﬁecember

ll,

1968

Dr. Leon Hellman

Hontefiore Hospital
210 Bainbridge Ave.
Bronx, New York

Dear Leon,

“Newborn

a paper
discussed with you, I am enclosing
Process
Pertum
Post»
and
Pre~
Sex Ratios Associated with
of
our third
one
who
is
Schizophrenia“ written by Dr. Taylor
is either a very important one,
year residents. The problem
interesting footnote.
as I think it is. or an
Dr. Gallagher would read
I would be pleased if you and opportunity for us to
arrange an
this and I would like to this
Please call me as soon
further.
discuss
to
together
get
chance to read this report.
As I

as you have had a
Science and until it
The report has been submitted to
ask you to use your
would
I
has been accepted for publication, this report.

greatest discretion in discussing

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Hszp

�</text>
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                    <text>September 19, 1971
Dr. Leon Hellman

Montefiore Hospital
Bronx, New York
Dear Leon,
My thanks for your advice and help for Mickey Taylor.
returned from his visit enthusiastic about his work and
duly concerned_thst a proper evaluation of his questions
required support and facilities that were beyond the means of

He

our Department.

0n inquiry in our medical school, he was referred to
Dr. A, Louis Sothren, who has some facilities similar to
your own. He has discussed the protocol with Mickey Taylor,
and following your recommendations a protocol is being prepared

for

NIMH.

I have urged him to consult
grateful for your advice and help.
My best regards for a happy

you and continue
new

to

be

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Septwbor 25. 1963

Miss Harm Hum

Jack 1hr Hotel
Van Nuns at scary
San Francisco, California

wmmx‘

Inbﬂdlikemmmmcifinﬁommmmrm
of Gaucher 8th. I anticipate

agar-1y naming
aftmaomgoaﬁd
batman
Oparticpants,mdmldappmiatoﬁu‘

availabilityofablaekboard. “Dumaimwwinpmbww

gommtil?z30p.matmidxtmrsm1aakﬁnpanicipants

lawman-mm
toadjmmmofmdiningm.
fer such adjommnt after the participants haw
magma
mtwlcmmllyouaboutmaowm.
muiumtmedoatmgsmiminthcmciﬂcmigm:

Roan.

Simmly yours,

W

m Pink, “-

Mhaw

D.

�</text>
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wwwmmgv

“W

Wrwv-Vt

~r.-

umm‘qu-Wl-wv

wuv-wvw

3*

WW
\W

October 1, 1979

Prof. Dr.

H. Helmchen

Nussbaumallee

1000 Berlin

36

19

Dear Helmchen,

for the reprints of your studies of the behavioral
changes in epilepsy. I found the work quite good and complementary to
our own interest in the effects of seizures in ECT. Over the years,
I have often wondered why more epileptologists did not take advantage of
the natural experiments which psychiatrists provide in the BCT process, in
aleowing a study of the interrelations between degree of brain change,
number and frequency of seizures, and psychopathology. When I did my
principal studies of psychopathology, in the late 1950’s, not as much was
known about the assessment of behavior and our work was quite coarse.Were
we to do the same studies today, our methods would be more detailed and
would parallel your efforts more closely.
Thank you

I also enclose a reprint of our recent study of the EEG
effects of phenytoin. It shows clearly that there is an intimate relation
between plasma level of phenytoin and BEG response. I think the failure
of many physicians to get behavioral effects in patients with neurosis may
be due to the low levels they used.
Again,

my

thanks for your help.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>June

&amp;, 1964»

Mr. Harry Bendernen
world Wide Medical ﬂew: Service.
130 Beet 59th

New

York,

New

Street

Inc.

York 10022

Dear Mr. Henderlon:

Fbllowing our discussion this-morning, I would like to recommend
the following for your consideration in your Roche Report.
On Page 4, following distortion of Dre. Berger. Gibbs, Devil and
‘Lennox,
will be appropriate to make some reference to studies
using frequency analyzers made by Hoesland in the late '303, and
by Dr. Mhrgnret Richard in the '503. Dr. Beaglend, working with
Haldane end Pincus. published an article in 1938 in which they
relate the behavioral changes in a group of depressive subjects,
and changes in.hormnnel level and EEG frequencies. Dr. Kennerd
has written a nnuber of articles on the differences
frequency
pattern between schizophrenics and other psychotic subjects. She
has indicated that psychotic subjects showed different frequency

it

in

patternl in different parts of the head as if the electrical
activity was poorly organized.

During the same period of time. Dr. Ulett, in St. Louis, using
frequency analysie, demonstrated that brain wave patterns differed
according to the treetmant results seen in his patients.

Concurrently, Charles Shaseee, new of the university of Iowa, and
Douglas Goldman of Cincinneti, used frequency analysis to show that
the cheese: in frequency pattern after a barbiturate differentiated
schizophrenic: from other psychotic subjects.

It

scene to me that e
the tap of Page 5.

Page 5,

ire”.

line

2:

I

summery

of these obeervetione subtly leads to

wnuld suggest the

deletion of the

word "eubject—

3

Page 5, paragraph
line A: ”...new wave forms of rhythms" should‘
be" ...new wave form. and rhythms.“
Page 5, paragraph 3, line 7: I would appreciate the designation
”The Missouri Institute of Psychiatry in St. Louis" rather than the

sentence as

it new

reeds.

�Mr. Barry Henderson

6-4-64

Page The

raga 6, paragraph 2: The phrase “Among the new wave forms found"
aeolian that the administration of drugs produced new electrteal
patterns which were not discovered by Gibbs at all. This is not
true. I think the phrase should read "Among the new wave forms
which way be introduced in the record...”
Page 7, paragraph 3: The quotation ascribed to me has left out a
word after "operational", and I believe
can best be completed
by "...the operational criteria for patient selection for these

it

needed basic

studies."

At the

present time the tasters which are known to
the hast quantative work are the following:
(1)

U. C. L. A. ~ Brain Research

to be doing

The computer

applications are headed by Dr. Mary A. B. Brazier, who
is.uorking with the methods of auto~correlation and
croaaneorralation, and by Dr. Ross Adey, who is actively
working with a power spectrum model. The actual investi~
gations into changes in the depths of the brain are being

am

(2)

Institute.

me

by ”to Riﬁhﬂrd Walter.

Inlans university - Department of Psychiatry.
Dr. Robert Heath has been studying the effects of drugs
on depth recordings in psychiatric patients using com~
pater methods with the base line cross method of EEG
analysis of Dr. Neil Burch as a model.

(3) Massachusetts General Hospital. Dr. Frank Ervin has
been actively involved in studying depth recordings
in a variety of patients using many different methoda‘

of aealyais.

Other cantata are opening up rapidly, and there is accent on it at
Haw York Medical College (Dr. E. Roy John),
University of Iowa School
of Medicine (Charlaa Shasass). and Duke university (Dr. Walter Obriat).

I

hope this information
an.important one, and I
of research.

it

am

of help to you.

I think your article is

grateful for your interest in this type
Sincerely yours,
Ha: Pink,

Director

MF/Jb

M.

0.

�</text>
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                    <text>July 2?.

1964

Hz. Harry Honour-on
world Vida Hodiool Now: Survioo,
130 East 59th Stone:
Nov York, New York 10022

Inc.

Dear Mr. Hondoroon:

I

just roooivod

1 copy of the Roche Report. and find
oxoollont.
I have had the opportunity
your prooontotton
to dioouoo it with George Uloet. and ho concurs.

hovo

Indood, no ltko the pronoutotlon so well that w. would
like to use it in justifying our program to out legislators this winter. Would 1: ho possible for us to receive
about twonuy-fivo additional copies}

Congratulations and

many

thanks.
Sincerely yours,

an Fink,
Diroot0t

MF/jb

M. D.

�</text>
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                    <text>January l5, l968
Mr. Harry Henderson
World Wide Medical News

l30 East 59th Street

New

Service. Inc.

York, New York 10022

Dear Mr. Henderson:
We have recently completed a small study regarding the
treatment of nercOtic addicts using a new narcotic antegonist.
The compound is of sufficient potency to be of great clinical
interest. Unfortunately, the compound is no longer available
because of the expense of production since the patent is held
by a small pharmaceutical corporation.

If. after reading this report, it is if interest to

you,

appreciate your calling me regarding the necessary
releases from the institution prior to public description.
I would

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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r,“
I.

Febmary 6, 1970
Mr. Barry Henderson
World Wide Medical News
110 East 59th Street
New York, New York

Dear Mr. Henderson:

for your inquiry about our presentation at the
This report was an up-dating of a review I completed
in 1968 and our recent studies in opiates. Copies of both

EPRA.

Thank you

are enclosed.

Sincoroly yours,

Prodbssor of Psychiatry
MF:kp

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[fl/jaw

December 23, 1976
Mr. Harry Henderson

Editor

World Wide Medical
880 Third Avenue
New York 10022

Press, Inc.

Dear Mr. Henderson,

is accurate, and I congratulate
you provide. I have a few comments that

For once, the reporting

you on the summary
may be helpful.

that

1. The effect of the Massachusetts reporting system has
been salutary, and the follow up report by Grosser in the
Massachusetts Journal of Mental Health, Spring 1975 could be

referred to.

The report finds that the institutions reporting their
seem to be following the guidelines set by the medical
communitym and such self monitoring is much to be preferred to the
EST

experience

California

model of

legal restraint

and

interference.

2. Leonard Cammer is a curmudgeon, representing the
opinion of himself and a few die-herds. He and-his associates
fail to see that with the development of third party payers, and
government funding, there will be regulation of medical practice.
Whether the regulation is made by the State and external to the
medical community, or by them-edical community is the issue. The
members of this APA Task Force seem inclined to develop models of
education and self regulation and it is probable that their thoughtful
recommendations will be accepted by the 20,000 members of the APA.
I believe you give undue weight to a very minority opinion by quoting
his (Leonard's) very conservative and 19th Century approach at length.
«m

".41:

-

WI7‘F'IYv

A
.

3. Dr Tien is a poorly trained, misguided therapist who
has produced many articles of uncontrolled,'studies'. His approach
is far from the mainstream of world psychiatry and again, you do the
serious students of psychiatry a disservice by quoting his remarks.
Better you should have quoted Dr. Friedberg, a young resident from
Oregon who did present the negative views of EST rather forcefully
in the same session at which Greenblatt and I spoke. The American
Psychiatric Association has decided, that despite the ad hominem
and erroneous nature of Freidberg's remarks, the American Journal
of Psychiatry will publish his remarks as well as those of the other
panellists at the session you quote. I would urge you to relegate

�H.

Henderson..........

December 23, 1976

.......... page

2

to his private world. Incidentally, your references to the
society in the same article as the established society suggests
that somehou, the new group represents the professionals who have
an active interest in EST. That is not so, since few of the
authorities that you may wish to quote and who have carried the
Dr. Tien

new

burden of research these many decades have joined

Cammer

and Tien.

4. Since that presentation, Avery and Winokur, in a
very forceful article in the AMA Archives of General Psychiatry
(33:1029-1037,1976) indicate the importance of EST in reducing the

incidence of death in depressive illnesses. Their findings are
striking for deaths by suicide, but equally for deaths from all
causes. I commend their article to you. Another important study is
that of McCabe (Amer J. Psychiat. 133:688-691, 1976) who finds EST
as effective, and often more so, than other treatments of mania.
The importance of his review is the data that the time for
response
is notably shorter for EST than for drug therapies—— a finding
that
should serve to reduce the mortality among manic patients who frequently succumb during the first week of treatment.
I trust these comments are helpful. While I have good
press photos, I regret that I am of sound mind and do not wish to
have my face presented in the lay press. My opinions matter
little;
the results of my research do, and when someone wishes to describe
my laboratory's work, I would be pleased to supplement the reports
with pictures.
My

regards and best wishes for a successful 1977.
Sincerely yours,

:-:

v...

-u,«.w.'

«n;

«t,»

q'w'

“wry-v

-..

war

:91

1m

ﬂi'jrﬁr

-

..
gun-w.

..

www.myv...

W

Fink, M.D.
Professor of Psychiatry
Max

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,.

4,

my...

April 16. l969
Dr. Richard Hendrick

Arthur
15

D.

Little

Acorn Park

Co.

Cambridge, Massachusetts
Dear Dr. Hendrick:
have discussed with Dr. Pars, I am sending you
be
ampule of THC with a request that
an
separately
analyzed for its content. This is one ampule of 50 that
we received from Dr. Albert Manian and Dr. Daniel Efron
of NINH. The ampules were marked as containing l0 mg THC
As we

per

2 ml

of

it

95%

ethanol sealed under nitrogen.

In some of our recent trials we have had less of an
effect than earlier and are anxious to determine if deterioration
has occurred.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>.

January 19, 1966
George R. Honinger, Md).

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»

\
...

m

"TV—w.

'_,._..,_,,...

.A

—
-

_~.—4»

-n—l

VF'J'vng‘

Doccmber

12, 1975

George R. Honinsor. M.D.

Associste Professor of Psychiatry
School or Medicine
Department of Psychiatry

Isle University
3h Park

Row

Street

Haven, Connecticut 06519

Dear George,

I receivsd your letter or December 9 and sympathise with
the expressions. I on plcssod to rocommond you for membership in
the Society of Biological Psychiatry and will vrito a letter of reference on your behalf. You msy wish to ask C. Shagsss or T. Itil

to second the nomination.

Membership in the ACE? is more complicated. Esothellow
one nomination s your, and I have planned to nominate one
of my studonts for 1976. The nominations for 1975 are slrosdy

is sllovod

closed.

or the societies that are active, the APPA seems most
responsive and perhaps your attendance at the next meeting would
permit you to Join in the discussion of the issuos which you raise.
The Society of Biological Psychiatry is not very active in such issues.
although thore was some interact in the California regulations of
EST and leuootomy at the lsst wasting. Perhaps there will be some
activity this your in San Francisco. Abstracts are requested by
January 15 for that wasting, and should be sent to Dr. Iver Small

in Indianapolis.

The last question is difficult for no. I have no inkling of the program for the 20~yosr rovisw of the ACKP.; You may
offer your suggestion to Jerome Lavina, Burt Schiclc, Philip May,
or Al Diﬂsscio, who usually scum knovlsdgesbls about ACNP matters.

Sincerely yours,

as: Fink,

M.D.

Professor of Psychiatry

MF/mr

�</text>
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                    <text>n

E

October 9, 1986

i
5

I

[

i

TO:

Fritz Henn, M.D., Ph.D.

FROM: Max Fink, MD.

Subject: Promotion of Emmeline Edwards, Ph. D. to Assistant Professor

E

E

i
i

i
E

i
E

E

i

i
i

I am puzzled by this request for advice as to promotion to a rank of
Assistant Professor of a scientist in the Institute. It has been my understanding
that the recommendation to this rank did not require Departmental consensus,
particularly for appointments in the Institute with the 'research' modification of
title. Or, is the proposal lierally correct, that Dr. Edwards is being proposed for
promotion to an ‘unmodified' appointment in the Department?

It a Departmental consensus is required, it would be helpful to distribute
of
copies her gig, preferably with letters "from referees who know and can evaluate
her work in relation to that of others with her academic credentials. May we also
have recommendations from our own faculty, such as Nisson Schechter and Bob
Hitzeman, who may be expected to understand her contributions?

,1 .v...r,,.

�</text>
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                    <text>. ~,W.',-W-n‘wa.._ ,___,._..._

_

s
,...

we.

WA.

July 15, 1987
Professor Fritz Henn, Ph.D., MD.
Department of Psychiatry 6: Behavioral Science

SUNY at Stony Brook
Long Island, New York 11794

Dear Fritz,

lam pleased to submit this letter in support of the promotion of Dr.
Krishnareddy Gujavarty from the rank of Clinical Assistant Professor of Psychiatry
to Clinical Associate Professor of Psychiatry. I have worked closely with Dr.
Gujavarty for more than four years, as a collaborator on research projects, as a
team-mate in both the in-patient unit at lO-North and the Affective Disorders
Clinic in the CPD, and as a fellow teacher and member of the Department.
I have come to know his professional work very well. He is a dedicated and
responsible clinician, well trained (in our own resdiency training program, I might
add), with a sincere interest in our patients. He shows good clinical judgement,
relates well to patients and their families, and is very well liked by our co-workers.
He reads the literature avidly, and often presents the latest clinical findings in our
case conferences. He has accepted additional assignments within the Department,
including the medical management of the cases in the Sleep Disorders Program
when it was headed by Drs. Mitler and Baker, scientists without clinical

certification.

His knowledge of clinical psychiatry is excellent, and he likes to teach. In
addition to the supervision of residents, for many years he has taught psychopharmacology to each rotation of third year clerks. Each year, he has accepted the
repsonsibility for presentations in our Grand Rounds program.

He has accepted numerous departmental administrative assignments with
enthusiasm; the latest is his appointment as acting clinical director for the inpatient unit at University Hospital -- a position which he is carrying out with elan.
In his research work, he has made independent observations and reports in
sleep physiology and convulsive therapy. At present, he is principal investigator in
drug therapy studies.

�His greatest strengths are in clinical care and the teaching of medical
students and residents. in his research, he has been slow to identify an area of
expertise, although his recent sleep studies show considerable promise of achieving
wider recognition.

lam delighted to recommend his promotion to associate protessorial rank.
He is a dedicated, reliable, and loyal member of our staff and we have come to
depend on him for his clinical and teaching skills.
This

letter may be shared with Krish.
Sincerely yours,
Max Fink, MD.

Professor of Psychiatry

�</text>
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                    <text>m
3

a

mm
,H"
1»3‘?

..
-

‘5

k

January 21. 196“

1r.

Hermaey

D. P.

mutant Psydﬁatriet
Lodcerbie We
Rainhill Hospital
St. Helena
Whine. Englm

Hr.

Dear Dr.

Hemmy:

ha

indicated an interest
in an appointnmt as research psydﬁstrist the Missouri Institute
ofPsydxietzy. This clinicalresearch mdtminingomterhas as its
Dr.

J.

C. Holden

of Lsncsshim

at:

prim-i palfomsstudiesinﬁxesevemmentsllyill,mdcamimbcth

clinicslendlsbcmtmypmgzm.
abilities

I

Wadesinplmcclcw,

would be grateful for your (minim regarding the research
of Dr. Holden,
well as your estimate of his ability to

participate in

a much.
@1de

My thanks for your cementim.
Sincerely yams ,
Max

Fink,

Director

MFsmlg

M.

D.

�</text>
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                    <text>December 29 , 196$

.‘Dp. Queues Henry
Book Review Editor
EEG

Jamal

Cleveland Clinic
2020 East 93rd Stmet
Cleveland 6, Ohio
Dear muck,

MfieldofEEGmddmgs isaomplexmeandthemare
omtributions of merit. Sane weeks
ago at the mo meeting I expressed my disappoinmmt at the
review of Dr. Itil's book as written by Dr...Goldnm. At the
time you indioated the diffimlty in selecting a reader who had
few students who have made

experience and

who

mderstood German.

WM...

.w

'v-w-r'1'vw

Irv.-

-rv-~&lt;

rw-

wv—nwaw

v.
24w:

'me review which I am enclosing from the British Jamaal
of Psychiatry is neither flattering nor disapproving. It is
an unusually balanced statmt of this W’s writs and

limitations.

It is

to oritise as the reviewerhas done - it is
I disappointed that the Editors did not use their
amateur! critical faculties in allowing Gold'nm’s biased review
to be published. Perhaps. they migat consider publishing
Dr. Homig's review as well ~ in part to give their readers a
betterpiotm ofthisworkmdinparttomensate forthe
mmual difficulties that authors have to defend thwselves
fm intewemte attacks in the press.
one ﬁxing

mﬁmrtofind feultwtofpemonal pique. I mwritingtoyou
because am

My

best regards for the

New

Year.

Sincerely yours ,
Max

Fink,

PM).

Mfessor of Psychiatry

Hfzkp

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                    <text>October 22, 196“

Edward V. Henry, 14.1).

Assistant Director
Clinical Investigation
McNeil Laboratories, Inc.
Camp

Hill

Road,

Port Washington, Pa.

Dear Dr. Henry:

I

trifluperidol
prefect.
Wefindmttmpetientearenwinmeetudy.
Ozmdoeegerangehaegmdmllyrismsothatnwellow'
patients receive doses of between 15-30 mg. for a mininun
few week period.
We are in need of additimal supplies and
would be grateful for you sanding us 250 bottles (50 tablb).
Dr. Don and

have reviewed the

However, since our doses are relatively high,

ifyouhavetrifluperidolinetebletofelergersine
5
2-1/2
such
emetic coated (since
as
or m. preferably
the taste has brmght complaints) , we
supply of these larger size, as well.

would

appreciate a

‘Iharﬂcyouverynuch.

Sinmmly yours.
Inf/ls

Max

Fink,

Director

PM):

�</text>
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                    <text>December 11, 195};

m. Edvard v. Henry
Assistant Director
Clinical Investigation
Mimics, Inc.
Fartﬂaahington, Pa.

W1

,

DaarDr.Henry:
We

have moaivad supplies of “Mayer-idol and. are

nowabhtooontinmampmgrm. W.Gentarcanedmm»

terdaymming. Aswamminﬂnmidetofatim limited
transfer, I was unable to spend the tin with
him and the new mpmaantativa, as you wasted in your

Wanda
letter.

,

named the dosaga of
mdimtiminallthepatientamdtheymnwinadosage
the antirange of 4-10 mg. per day. we. have ~aihw
mdioatim, and at these mange levels, the clinical
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two'weoks, we will mimtitute the mtipaxkinscn mdioatim.

tothosoofatherlabmdourdatashmﬂdbemmmbh
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than my be other
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mtituﬁmgr other

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moot-63 regarding

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nec—

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Iwouldbegmtefulforanymfmnmsﬁmtyoumy
rave mgardingﬂﬁshighdosagelsoﬁutwemybeable towrite
a batter dammed report.
essary.

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112m): you

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for your
‘

Sincerely yours,

Max

Pink, ".13.

Director

�</text>
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                    <text>_......,....,..,..,—

July 3, 1975
Mrs, Margaret Henry, Secretary
American EEG Society
4137 Erie Street
Willoughby, Ohio #4094
Dear Margaret,

I have been asked by one of the resident trainees at
our University, Dr. Simon Sanchez, to write a letter of recommendation
on his behalf to the Society.
I am embarrassed by the request, as I am unable to attest
to either his training ror his ability in EEG. He did not attend my
seminars, nor has he workéd in my laboratory. He has worked with one
of my students, Dr. Abrams, who has never participated in a well
defined training program in EEG. I do not know the ability of Dr. Su.

that

For

he obtain

My

this reason, I

letters

from

written.to Dr. Sanchez suggesting
his immediate supervisors.
have

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

,

a" _

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                    <text>.1

-' “M‘V‘rmw

1'

.xv—w-r

'x

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\\

a“ v"

1

'

-'

,~

~ -

V

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r

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raw-or:

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.‘

3\

January 14, 1971
Miss Sherrye Henry
WCBS«TV

51 West 52nd

New

Street

York, New York 10019

Dear Miss Henry:
Thank you for the opportunity to read your editorial
”Amphetamines for Children“. The evidence for the successful

use of central stimulants in hyperactive children is clear,
and, as you stated, often appears magical in reducing hyper—

activity so the child, his classmates, his teacher and family
are delighted. Fortunately, tolerance does not develop and
treatment can be continued as long as necessary.
is not unusual and no
prolonged use has been defined.

The metabolism of amphetamines

complications to

its

It is a truism that no chemical which is given to man is
absolutely safe, and in each instance the use of a medication
must be balanced by the potential gains and the potential risks.
In this use of amphetamines, the gains are obvious: the defined
risks non-existant. There is no evidence that the use of stimulants
in childhood leads to abuse in adolescence. There is clear evidence
that hyperactive children, if untreated, are disruptive; fail to
learn, are stigmatized and may suffer prolonged handicaps.
I would, of course, concur in your suggestion that medication
for this illness be prescribed by trained and experienced professionals.
But I would suggest that your emotional response to the problem colored

the editorial unnecessarily and to its detriment. The last two
sentences are emotional outbursts, not in keeping with the leadership
and dignity of WCBS. In the text, the selection of such negative,
emotional words set a tone that is unfortunate: "jazz adults up",
"black magic”, ”drugged”, ”drugging him to submission".
—

wrap-

�Miss Henry

January 14, 1971

—2—

While I agree with the central message, that treatment should
be used sparingly where required and under professional supervision
I think the tone, emotional attitude, absence of facts demeaned the
not clear that a reply would serve a constructive
message. It
the community expresses considerable anxiety about
unless
purpose,

it

the message.
Again,

my

thanks for the opportunity to consider

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

NF :kt

this issue.

—

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                    <text>11-.

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July 31,

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                    <text>August 16, 1978
Mme.

Dahin Herbillon

Bruxelles, Belgique

Dear MEI. Herbillon,

I regret that the proceedings of the 1978 meeting in
Vienna are not available as yet from the various authors. They are
requested to submit their manuscripts to the editors in Vienna by
the end of September, and I do not have copies from them.
However, you may wish to obtain copies of some recent
on ECT which I have written to start you on your effort. The
following are recent summaries which may be useful.

reports
CNS

Sequellae of

Shagass, C.

N.Y., Raven

EST: Risks

of Therapy and Their Prophylaxis. In:
and Brain Dysfunction,

et al (Eds.): Pszghopathology
Press, 223—239. 1977.

Special Case in Pharmacotherapy. In: !.E. Fann et al. (Eds.):
Phenomenology and Treatment of Depression, N.T., Spectrum Publ.,
285-291., 1977 .

EST: A

Myths of "Shock Therapy". Amer.

J. Psychiat. l3hz991-996, 1977.

Efficacy and Safety of Induced Seizures in

Is

EST

Man. Cogprehens.

Psychiat.

a Useful Therapy 6f Schizophrenia ? In: J.P. Brady and H. Brodie
Controversy in Psychiatry, Phil., W.B. Saunders Co., 183-193, 1978.

(Eds.):

In addition. I have Just completed an extensive review of
convulsive therapy and the volume will appear in Jabuary. It will be
published by Raven Press in New York and will be the most extensive
review available. If you can wait for it, I think you will be satidfied
with the documentation of the facts about convulsive therapy.
My

regards to Dr. Mendlluicz.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>7383—637

April 2h, 1973
Mr. James

J. Eberlein.

Pfizer IMug

235 East hand Street,
York. R.Y. 10017.

New

Dear Jim.

It is with rcgrct that I reqnnut withdrawal of
thn exhibit ”Drugs, EEG. and Behavior” tram the APA
ﬁhia year. In reviewing tbs material which we have
submitted, I have bacon. concerned that the information
praaented could be misinterpreted, and not enhance
our pwogran.
I

am

moat

grateful for your

many

excellent

suggestions 5nd the support whieh yen have given

prosoet.

this

I hnvc taken thn liberty of notifying the APA
ottiee and am analosing a copy of my letter to them.

Again,

my

thanks fbr your cooperation.

sincerely youri.

Fink, M.D.
Professor of Plyohiatry

Mix

ur/id
Ens.

�</text>
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                    <text>Juno 3, 1964

Dr. Ross

Harmon

631 Osborno Building
Claytlnnd 15, Ohio

Dear Dr. Harmon:

for your inquiry. The Missouri Institute of
and training center of the Division
rosoarch
tho
Psychiatry is
of Montul Diseases of Hisoouri. It was established in October,
1962, with laboratory and clinical facilities for roooarch. At
the present tins, of 150 beds, on or. utilizing 70 for research
purposes. Laboratories are established in pharmacology, psychology,
and cloctroonoopholography, as wall or a computer cantor for both
statistical and EEG analyses. Thorn is s opocializcd psychiatric
roscsrch lihrsry as a component part of the Institute. Animal
facilities oro now being built.
Thank you vary much

In addition. thorn is s fully qualified throo—year paychistric
rosidsocy training program at the Institute, and a special train~
progrsu in olinicsl psychology is being established. Both in
its
tho roscorch programs and in the training programs, the Institute
is affiliated with the Department of Psychiatry of Washington
University School of Medicine.

it

tho proosnt time, thorn arc s number of research programs in
progress. Theta include Lithium as a therapy for mania; the use
of Yohirbinc as s precipitant of anxiety sud tho develop-ant of
anti—anxiety cgcnts; rolation of EEG patterns and organic factors
in the troatnont of therapy rutistant psychotics; computer analysis
of tho oloctroonccphalogrsm; the effects of drug withdrawal on behsvior in the chronically ill; and the treatment of psychotics by
nursc relationship therapy.

I on enclosing a description of the Institute. If this opportunity
intorosto you, I would appreciate a copy of your curriculum vitae
listing chronologically your educational and professional experi—

ence, and reprints of each of your publications, if available. In
addition, a small photograph and the canto of at least two referees

to

WhOM‘HI may

write

would bu most

holpfnl.

�Dr. 3030 Bataan
6~3~64
Page The

I

look farward to processing this application, and would like to
arrange for you to con: to visit us as soon as we have received
name

of this information.

Sincerely yours.
ﬂux Fink, H; D.

Dircctor

urtb
Bnc.

�</text>
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W

March 14, 1992
Werner Herrmann, MD.

Clinical Psychophysiology

Freie Univesitat Berlin
Eschenalle 3
D-1000 Berlin 13
FRG
Dear Werner,

First, about the IPEG Program. Turan and I met yesterday and
completed the program, worked out the program printing, and made suggestions
regarding the social calendar for the meeting. It looks good.
With regard to the MacNeill et al report in Neuropsychobiology. I agree
that you accept what you deem useful. When reviewers differ as to their
recommendations, I do not think ’democracy’ is effective; the editor must make a
judgement based on the merits of the paper [as he sees it] using the advice of
reviewers for specific points.
You ask how I proceed as editor of Convulsive Therapy. I see the role
of the Editor as ’gatekeeper’and as a ’leader’. I try to determine whether an
original article asserts something new, whether it is likely to be true, and whether
it is likely to be ’true’ in a few years. Articles that meet these criteria and the
support of reviewers are accepted with enthusiasm. Other articles are accepted if
they usefully teach -- an experience that might be useful to others, or a technical
point that has merit. If the report is an opinion piece -- a commentary or
editorial -- I ask that it be related to something published recently, or that it
makes a new argument. Finally, reviews are very helpful if they are reasonably
complete (I check the citation lists myself) and if the conclusions may be helpful
to the reader, whether as a student or as a researcher.
The Editor is expected to stimulate and request articles that make new
points. I often leave a scientific meeting with notes that lead to letters and later
to editorials or reviews which I publish.
The section on pharmaco-EEG in Neuropsychobiology has not made a
concerted effort to improve our practice. As I recall the articles, they are mainly
archival reports of studies that follow standard models. Many are not definitive,
weakening our message. They have rarely been accompanied by critiques or
editorials.
‘

�Werner Herrmann, MD.

Page 2

The next IPEG meeting has two important issues that warrant
publication. The papers of the Classification Symposium may usefully be
published, perhaps as a special supplement, with a discussion of the relevance of
animal models for clinical psychopharmacology. Opinions are divided between the
pharmacologists who have a distinct faith that rat studies are the road to defining
new psychoactive entities [after all, it is their livelihood], and the clinicians who
recall that almost all that is useful in clinical psychiatry has come from clinical
efforts, and that so far, no new compound or idea has come from pharmacologic
studies.

The PK/PD symposium exemplifies a most useful application. It
deserves a separate publication, with a discussion of the BGA and FDA positions,
and arguments that pharmaco-EEG studies in man have something to offer
clinical medicine, something more than is offered by routine PK/PD testing when
applied to psychoactive (and neurologic active) drugs.
My principal argument with Kiinkel was that he appeared passive in
attitude, leaving the section archival and ’no fun’ to read. Miiller-Oerlinghausen
made a good point in the latest issue of Pharmacopsychiatry, when he accepted
your three papers and then asked me to write a commentary. The ’package’ should
have been part of the Pharmaco-EEG section of Neuropsychobiology. [Is it
premature for two journals to compete for the limited pharmaco-EEG material?]
As editor of the section in Neuropsychobiology, it will take much work;
a good beginning can be made at the IPEG meeting where you should try to

capture the best papers.

My best regards.
Sincerely yours,

Max Fink, M.D.
Professor of Psychiatry
,

�</text>
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                    <text>December 27, 1993
Werner Herrmann, MD.
Clinical Psychophysiology
F reie Universitéit Berlin
Eschenalle 3
D—lOOO Berlin 13
FRG
Dear Werner,
I received your Fax regarding your nephew and took it up with Fritz Henn.
He will ask for approval from the Dean’s ofﬁce and should know within a few weeks.

We have had such scholars previously. Our third-year students have a
clinical course of 6 weeks which is both didactic (lectures) and clinical. It is preferable that
he be assigned to work on 10-North at University Hospital and if possible, should be there
when either I or Fritz Henn are ‘on service’. When approval comes, let me know what
dates he has available and I will advise you how to maximize his experience.
My best wishes for a happy and healthy 1994!
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
and Neurology

�</text>
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                    <text>Septembar 20, 1973

Ralph

W.

Ridhtor.

M.D.

Harlem Hospital Cantor
135 Stront &amp; Lonox Avonua
Haw York City 10037
Dear Ralph.

to have an opportunity to ravine the
chaptor on narcotio antagonist: for your volume, as there havo been
some additional data. particularly with regard to nnltroxono, which

I

was plunged

should have~been included.

'

'

Enclosod 18.1 rovidad draft of the roport for your
will be accopcdble.
consideration. I trust

it

my

boat regards.
Sincerely yours.
4L£f

.vW
Max Pink, 24.13.
Professor of Psychiatry
u. v

�</text>
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                    <text>20 March 1974

Mr. Soonel

Pilate

Dopartmont of Psychology

Boston Univoroity
6o Cunnington Street
Boston. Massachusotto 02215

Pilate:
Encloood is a

Door Ht.

copy of tho

presentation that

you requootod.

otudioo which I haw. quoted worn done more than ten years
I undortook studios of unilateral and bilateral convulsivo thorapy, I did not include lanauogo uoaoutoo. I do not
know of anybody also who has. but I do holiovo that a study using
syntactic and TTR measures in patients toooiving unilateral ECT
should present differences whothor tho cloctrodos veto on the
dominant or nonndoainant homioﬁhoro. It would bu o vary good
The

ago. when

Ittﬁy

0

Good luck in your studios and my best regards to Canon
notoky and Allen Miroky, ohoold you know them.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

HF/ois

ﬁnal.

Kor—

�</text>
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                  <elementText elementTextId="104043">
                    <text>rnw-V=—‘

r.

«cw

vw-M».

”Q.

_

..,.._.

:"‘-,Q;w,ug~w’m4I“V-‘VIV\

w.” w

H...

,.

- M”, .nz-n—r- m-L'r
.

.. ~

,

.

.

——.~w-mw—.~v am

“7"?"—

3.8%”

May

n, 1978

Werner Herrmann, M.D.

Schering

Berlin,

AG

Germany

Dear Werner,
The two

citations in your recent letter are not

available as reprints.

The report in the Drug Information Bulletin was published
in the volume Pharmacokinetics, Blood Levels and Clinical Response,
edited by L. Gottschalk and S. Merlis, Spectrum Publications.
New York (2u3—2so), 1976. A summary of the findings was also
presented in the 1976 volume edited by Matejcek and Schenk of the
proceedings of the second Vevey conference.

report by Glasser et al.
and has not been published.

The

satisfaction
other in

Good

was

never completed to

luck in your studies. I hope that

Vienna and perhaps in Basle.
My

we

will see each

regards.
Sincerely yours,
Max

Pink,

M.D.

my

Professor of Psychiatry

�</text>
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                    <text>{I

i
g

“um-umw-www

"v

rm

'.

Dcceﬂber 12, 1977
Tb: Antcl Kerakovitz
From: max Fink.

M.

SubJect: Eugene

MbDermott

D.

Departmcnt of Psychiatry

I have been a user of the Media Services for the past year.
In this time, I have been pleased with the variety and quality of

the services available. Mr. Habermott has always been courteous
and relidble in his service, and the quality or the work has been
most satisfactory. I comment him, and his cedworkera for their
efforts. and trust that their sarviccs will continue to be
available.
MFz'bc

�</text>
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                    <text>March 28, 1967

Prof. Dr. A. Herz
Max-Plandc—Institut
..
Deutsche Forscmngsanstalt fur Psychiatrie
Kraepelinstrasse 2

‘

Munich 23 , West Germany

Dear Professor Hers:
Thank you for your kind invitation to participate in the
support of a new journal "Pharmakopsychiatrie - Neuro-Psycho—

It. would

be an honor to participate in the
journal, especially one whose title is so
close to one that my associates and I have discussed frequently
during the past few years. I am pleased to accept your
invitation to submit a report of our studies.

pharmakologie. "

launching of a

new

As you know, I have been interested in a number of aspects
of neurophannacopsychiatry, including the theoretical issues of
the reﬂtion of brain changes (EEG) to behavior with drug
treatments and ECT, including such special problems as the
identification of new drugs and of drug sensitive populations.
We have also actively studied the practical issue of the best
way to quantify the changes in the EEG using digital computer
analytic methods and the best way to quantify behavior, using
item analysis with rating scales. To assist me in selecting
an appropriate representation of these studies, would you let
me km»: more of the oozrposition of your editorial board (anyone
from the U.S.?) or, is there a statement of policy already

enunciated?

Sincerely yours ,_,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Hammer 12, 1965
Dr. A. Hem
Hax~Plendc Institut

Kraepelinetreese

timid),

2

Germany

Dear Dr. Kong

the C;I.H.P. Program Comittee for the forthoming meeting
on
28-31, 1965 hes asked Dr. Philip Bradley

in Weehingtm

M

mdmymlftommgeeeymiwmmgemmltopicofmmo—
We have

phegmoolggy.
sub act o :

(helm to

ANTIGiOLINEMIC

mge e symposim on the

W8.

'Mtiolwlinergio hallucinogem have received considerable study
and the data relates to the pmblm of
nervous system
oholimrgio mdmim in the therapeutic effects of mime
somatic treatments, and to the special problem of the dissocia~
tion of EEG and beheviw.

:3an

'

Recognizing your experience with these

mas

interest in these problems we would like to invite
participate in this eynpoeim.

you

and your

to

1. If you are able to eooept this invitation, would you
please send me a proposed title for yow presentation, and e
short paragraph describing the foam and type of data you wish
-

to present?
Upm

receipt of those adamledgmte,

Dr. Bradley and

willmkeupemoonmdedprombalemingtmtime for
presentetima and dieoueeime.

'Ihe C.I.N.P. Committee has

this mime will have at least
eimltmeous translatim,
so that reports may
agreed that

I

one session of.
be promoted in

the language of yaw choioe.

2. 'lhe C.I.N.P. has not stated a general publioetim policy
mdismione as a

mdwe pmpooeto publish these reports
separate volm.
_

.

3. The C.I.N.P. anticipates that eedx participant will pay
his own 0mm in attending this meeting. For those attending
this mting.from Europe, e clatter flight may be organized by
Dr. Philip Bradley. In the amt that travel fun&amp; are necessary,

�‘

Dr. Ken

'

.

funds and we

will

mm: muestod

Wt

please indimte the

November 12, 1965

~2~

to supplemnt your available
these requests to the Program and

martin Camittus for their decision.
u. The Mitten has asked that we indicate mam-Its
mbeingmdehy:
-

His: Margmt

Taylor

K.

c/o CJJM’. Semtariat
3636~16th

Street,

NM.

.waahingtm. n.c. zoom

Ifymmplmingtomﬁxis

dinctly?

Dr; Bradley met

swim.

I

look forward

mating. wouldyouwritetoher
to having you join us in this
'

_

shapely ywrs,‘
Max

Pink,

m.

mecsaor of Paymiatry

�</text>
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                    <text>Jmuary 18, 1966
Dr. A. Hers

Max~leok-Institut
Krsopeliastmsse 2

thich,

Gsmﬁxy

Deer Dr. Hers:

I are pleased to confirm the invitation for
in
the sysposiwn on Antidaolimrgio Hallucinogeas
participation
ymr
at the forthwning metiag of the cm? to be held in Washingtm, D.C.
on March 29 and 31. We look forward to the presentatim entitled
"Some aotions of molinergio and entimolinergio dmgs on behavior. "
As them are still .1 few questions about the ability of sane of the
Emmet invitees to attend the meeting, it will be a few weeks
befom no em smd you a definitive program, and time schedule.
Dr. Bradley me!

Five reports

will be preseateddmdng em three session.

thirty—five minutes for cam pnesentetim end disonssim.
Sines the discussion may be of special iatemst to the participants,
ﬂuxepontshouldbeebmt‘mmimxtes in length.
We have read the abstracts which
you have snMitted with
greet interest. Sims time limitations may reqnina some selections,
the description of the potentietim of "Earphone-stupor" by aati~
oholinergic drugs an! the simifioanoe of molixuolytic eotivity in
mtideprsssivs drugs my be more appropriate to the general dismsions.
memuismthepmsmtoboonthemletimofnetm—
physiological dzanges to behavior, with some «aphasia on the problem
of ”dissociation. " me other invitees who have indioeted a desire
to partioipate are Dos. bongo, White, Dmim. Hint-vim, Bradley,
Carlton, Voteva, Bursa, Hem, Vetdem, Ilyutolmok, Itil, Jeakner

and Vojteobovsky.

The CINP has permitted us

to consider the publioetim of this

sepemtely. Insofar as this subject is booming
swim
increasingly iuportmt, we believe that the association of the

of the participants in a single voluse will be a valuable
amtributim, and ask your cooperation in making e manuscript
sileble at the time of the meeting. The mamaript should
be approximately twentyipages of text, pltm bibliography and

work

illustrations.
We

look foxwerd'to yotm pmseatetion.
'

'

Sincerely yams,
Max

Pink,

PhD.

Professor of Psychiatry

HP:kp
,

-

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3911.“me

woman
Invelmd
Division

W,
wntmn:

P. 0. Box 381

Department
‘

0010mm 80537..

I mad appraeiate my information which may be available
on your elemnesﬁweia instnmnt, as éesm-ibed in the

hunt

issue of Selena. man): you.

31ml); yous,
ﬂax Fink. M.D.

meesaor of Psydxiatry
.

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1965

Sanbom Division
Hewlett-Packard Oonpany
Waltham, Massachusetts

Gontlennn:

I would appreciate a ample of the new Sanbom
for trial in this laboratory.

Redux Cram

Sincerely yours ,
Max

Fink, NJ).

Professor of Psychiatry

�</text>
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Dr.

For:

J.

Robert Reason

Wm. Pamsylvmin

1903“

Duran Hum:

Itmmalmtaymahmm. Beaverandldiacusaed

minvestigatimoftﬁﬂmddol.

and is nowcaapleted,
studywas began in September
mdefmdingsmdmnminthepmsaof
Wehava
19614

‘wrdtingafinalmport;

I‘belisvaitwmldbnhelpfulifyouemldmmgatovisit

usmgomrthismwdalwmdiswssmfmplans.
'Ihmk you wry

mach

for your mwpemtim.
Sincerely yours,
Phx Firdc, M. D.

Professor of Psychiatry

�</text>
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                    <text>June 11. 1965

Dr.

.

J. Robert

Hewscn

Assistant Director
Clinical Investigation
Lebomtor'iee
mil
Road
Hill
Cm

Part Washington, Pemeylvmie 1903“
,

Dear Dr. Ramon:

Since writing to you on June 1, we have sunmrized our
obeervetiam with triflupeuidcl. While we believe that the
first study is now caupleted, and the report will be submitted
very shortly, we find that we would like to treat an additional
ten patients, if poeeible. For this purpose, we find that the

,

empliee cf trifluper-idcl available to us are limited. We
like to muest 500 additional bottles of liquid triflu~
peridol in e concentratim of 15 33 per bottle and 500 bottles
of placebo. Cm these be made available to me?

would

We

look forward

to having you visit with us.
Sincerely yours,
Mex

Pink,

14.

D.

Professor of Psychiatry

�</text>
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                    <text>June 30 , 1965

Dr.

J.

Robert Human

Assistmt Director
Clinical

Inmti

Liberate
W1
Cup Hill Road

ation
as. Inc.

Port Washington, Permsylvmia

Dear Dr.
Both

190 3%

Mam:
the.

Dan, 11:11 and

I will be available

duringtiurminderofJuly, andlodcformxdto
your visit.

Wyouvatymdtforscndingmtheadditimal

triﬂwaridol. I will

bring the mange in concentration

O‘an

and the other mentors
to the attmtion of Miss
of the staff who will be: using this pmpamtion.

81:10:me yours,
ﬂax Pixie, Md).

Professor of Psychiatry

�</text>
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                    <text>July 8, 1965

Dr.

J.

Robert Henson

Assistant Director
Clinical Investigation
McNeil
, Inc.

Modes
Road

Cm Hill

Fort Washingtm,

Bar

Pmylvmia 1903‘:

Dr. Hewsonz
Wu

and wish

meshed the additional supply of trifluperidol,
to thank you for your assistance.

have

Your letter of June 25 indicated that you wwld be in
Midwest
the
between the 12th and 23rd of July. Hy present
requires an to be away on July 19th through the 21.31:.
I would be pleased you could visit us before that date or
on the 22nd or 23rd.

3W

if

Sincerely yours ,
ﬂax Fink, PM).

Professor of Psychiatry

�</text>
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                    <text>August 21, 1965

Dr. J . Robert Hausa:
McNeil Laboratories

Hill

Camp

Road

Fort Washingtm, Pennsylvania 196.331;

Dear mu Howsm:

mats

lhmk you very much for your
of the draft
"Trifluperidol Therapy of the Severe Mentally Ill."
We

have taken your cements and are

(V)

of

oomoting the next

copy. The EEG material, rating scale data and the laboratory
data have mm been brought up~to~date and them will be another
draft available, which no plan to send to you.

In the meanwhile, we have no objection to you mferring to
the context of this paper either- with or without identifying us
as the investigators . By all means , those obscrvctims should
provide the basis for additional study.
be

prefer that
stated as possibilities, for wo
However, we would

any references to our
would likc to msem

oonclmims
the

privilege of modifying the statements in the final draft which
would be available within the next few months.

Incidentally, since your visit, two of our patients have
sham a very salutary respmso to trifluperidol after previous
failure with chlorpmmazino thorapy. Also, two of the patients
who had failed with trifluperidol have also failed with butapemzinc
and we believe that they am to be included in our "Thempy Resistant"

M

-

’Ihank you very mom

for your visit.
Sinoomly yours ,
Max

Fink, Md).

Professor of Psychiatry

MP:kp

cc:

Dr. Em

�</text>
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                    <text>"
WV

/’.II'F""

ran

rnmxw-nmsnr

Sopteuber' 23, 1955
Dr.

J.

Robert Bowen

Mail

laboratories

Cm Hill

Road

Port Washington, Pennsylvania 3.903%:
Boar Dr. Ramon:
We

have

thc'mpor't.

the trifluperidol
mhtod.
full draft

The

study and have rewritten

is Ming mtyped

and

will be sent to

upmtaly. It is our intention to condense this dmft and
submit it to one of the journals for publication. Have you any
sumtions as to whom we may send it?

you

In this draft you will note that we have made some of the
mootims Whid'l you how suggested. You will note, however,
that us have included in this draft a paragraph about our
butapomaim emionoo. The failure of the subjects to respond
to this potent pluanothiazine ao well as; trifluporidol reinforced
my belief that we had selected a group of therapy resistant subjects.
In mviming the psychopathologioal data we did find that variom
disturbmoos mowed mliomtim. We did viait Dr. Danika-r in
Pain: last math and found that his population was a mob mom
acute one and we believe that his favorable impmsaim of the
is related to the population diffomnoes .

WWW

In the maritime, we have collected all the data of our
laboratory studies and have written individual case protocols .
Both of these are being prode and will be sent to you.

During the last visit you requested sauna additional data
and
is unclear w to what we should make available to you.
We have
my rating scales, and the full EEG records. Is any
of this mterial to be duplicated?

it

ac":-

.:vw.-,—-:av-xrv

.v-r

I

would

appreciate your calling

or having

clinical

your
be omploted.
mom associate visit me so that this project can
me

‘

‘
‘1

11v”

Sinoemly yours ,

r‘vfnw:

-—

wwrwm

Vanni-war,-

Pink, [4.1).
Professor of Psychiatry

Max

�</text>
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                    <text>Novonber 1, 1965

Cmp

Hill

Road

Port Washingtm, Pennsylvmia 1903M
Dar Dr. Howam:
Separately I am sending you mu copies of the Import
"Mfluperidol in the Matmnt of Psychosis" which we have
We have sent copies to the editcr of the Jamal
minted.
05 New may for his consideration for publication in that
journal.
A

.

I wrote indicating that we more completing
know if there is any additional
in omimeticn
this study whim we cm prepare

few weeks ago,

this “port md would like to
with

1:1th
or you.

Ishalltrytoeallyoulgtormthisweek,orifyouhavel

the opportmity, would you call

me

at

m,

HI

5-62“?

Sinaamly ycmm ,

Mu Pink, Hm.

Professor of Psychiatry

Mfzkp

�</text>
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                    <text>’

Was

Dr. J. Robert Phonon
Mai-11
Cm Hill Road

Fort Hashingtm, Pamwlvania

Washer 16,

19033

1985-

,

Dear Dr; Rowena:

is the additimal infatuation
requested.
Wad
Miss
the:
has
O'Par'mll,
name,
mam
wanted
in triﬂuporidol dosage inn graphic
tom;
ngmsmwpwiﬁmmamriuwhimymm
hold, it uhwld be simplc‘to deﬁning the mate of
3mm

W

mo

By

triﬂuporidol and: patient mivud. m mounds also
medication far am of the patients
indicate the
and while this is not gem-to yum inmdim int-mt.

amt

it is Wfdrus

this in your copies.
Dr.

,

and

Ihmdaeid‘odnotto‘delcte

Itilhupcmimdmtosmdyoucopiesofthe

reports on man for those patients who hm been assessed
in a clasaidal fashion. In additim, he has decided that
htwill witc a sway of trifluperidol and Em. which will
be submitted for publication separately. man this is
available, it will be sent to you.
,

‘

,

sincerely yours.
HaxPink,

14.1).

‘

martin Director

HEkp

�</text>
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                    <text>January 10, 1986

Dr.

J.

Robert Henson

Assistant Director
Clinical Investigation
McNeil Laboratories, Inc.
3111 Road
cm
Port Washington,

Pennsylvania 1903!:

Dear Dr. Hewson:

In response to your letter of January 6, I have asked
the nursing supervisor to obtain the information regarding
the daoleeterol levels in our patients receiving trifluperidol.
As soon as that is available I will send it on to you.

I have had a amber of questions raised about the draft
of the triﬂuperidol report which I sent to you. One of the
questions was a better jmtifioation concerning the bipheaic
effects m actor fmctim related to dosage which we noted in

ourstudyprogrm. As Imviewedourdetalbeomm
impressed that this cowound may very well have mticholinergio
properties at higher dosages. While I have men stimulated to
elaborate this view in the demeim, I would be interested in
any edditimel 0mm you might be willing to make at this
time regarding the potential mtidmolinergic properties of this
ompmmd in higher dosage.
Sincerely
Max

Pink,

yam ,
PM).

Professor of Psychiatry

Hszp

.

�</text>
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                    <text>Janmr'y 20, 1966

Ir. J .

Robert Hymn

McNeil

Wanda,

Assistant Director
Clinical Imutigatim

Inc.

Port Washington. Pmsylvanin

Bar

1903‘:

Dr. Human:

data
m the additiomlIntrifluperidol
addition, the
havemicwod
mimofmJ —ome.
moo-mats 'hlsadmamiaim
Emloaed

which you

mently mated.

WW
santbothto
ofthadmftwhichwehndorigimlly
-

1mm

azrlto you. Eminent! is a revised eapyofour present
dmft for yam records and consideration.

adimm rave writing in us that their policy
page charges for articles maptod four publication. Insofar as this Deparmt of Psychiatry has
not appmvod such charges previously. I have been
unable to give the oditar a definitive response. May
I ask if you would be mtmsted in waiving capies
of reprints of this mm whm it is mbliahod, and
if so. if McNeil
mid be willing to
participate in the mppart of this ﬁnalisation?
TM

Mud“

Wins

Many

thanks.

Simmly

ma,

1“” Pink. Md}.
P90133509

of Psychiatry

�</text>
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                    <text>Dr. Jonathan 0. Cole

Netioml

Bank

Building

6917 Arlington Road

Bethesda, Maryland
Deer Jonathan

faded with e amber of technical and administrative
with
regard to the preparation of a grant application
questions
New
York
Hedieel Galley for the Ice—establishment and
free the

I

am

malytio program for "BBQ and Human PsychoRetherﬂmepmdﬁmtimonﬂretelepmor
in letter. I believe we both will be in Atlantic City for the
meetingamxtwasm Implaminatemive Tueedeyeftenmn
and Thursday. Except for my
and will be available
2:08
preheateﬁm on “muredey at
pm... I can set aside any tine
development of an

Wiley."

may

on the rant of the schedule.

that

I

we

assist

would be

Wain). if you would indicate a

My

m

in the privacy of yew
to
in the preparation of this project application.

might get together

me

half—hour

twat
Sincerely yom‘e,

m Fink,
Professor of Psychiatry
24.13.

ﬁxjmh

�~2-

Dr. Human

Effective June 1,

my

May

7,

address will be:
Fink, NJ).
Professor of Paychiatry

Max

York helical (bllege
Avenue at 106th Street
New York, New York 10029
New

Fifth

Again. many thanks

for your cooperatim.
Sinonmly

yam .

M,

w;

ﬂax Fink, Md).

Profassor of Psychiatry

‘vv:'mvi“v.&lt;“'7-

—r

.7

“

l‘ﬂﬂ—n-wnm’.v~r;y~

'wu-maw

Hfzkp

1966

�</text>
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                    <text>May

m».

J.

Robert

10, 1965

Wm

Assistant Dimamr
Clinical mwaﬁgaﬁm
McNeil Laboratories, Inc.

Cm Hill
Port

Road

Warm, Pemmylvmia

Dear Dr. 33mm:

Ebnmixgyourlemr,wehavechecmdmmfileaamifind

1:13:9an suppliesmbeingmtmd under sepamte cover.
tablets

tablets/bottle

12

bottles

12

bottles «lmg/ml—mmlhort‘tles

82
2»

-—

5 mg

We - 2.5

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so

13/1111
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Was - 1 mglml

mm): you

my mm for WW Wﬁm.
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1m,

Fink,
m
Professor of Psychiatry
MOD.

1'?sz

�</text>
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                    <text>September 12. 1966

Dr.

J.

Robert newton

Aeeietent Director
Clinical Investigation
McNeil Leberetoriee. Inc.
Carp Hill Road
Port WeehingtOh. Penneylvenie

D.”

Dr. HMO!“
under eeperete cover I an eending you three
hundred capiee of the reprint "Triflnperidol in
the Treetnent of Peythoeie.‘ I have dietrihuted
one hundred to the authore. I have already

received epproxinetely forty reprint reqneete end
will retein an additional titty to nnewer the
reqneete ee they cone in.
Incioeed ie en invoice from the Jgggggl at
new Qgggg. I would appreciate it it Hcﬂeil
Lebdretoriee would he ehle to pay thie invoice.
1 en noderetely'vell eetebliehed in my new
and would he pleeeed to hhwe you visit
facility
on one of your next tripe to new York.
Sincerely youre.
Mix

Pink. H.D.

Profeeeor of Psychiatry

�</text>
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                    <text>April

20 , 1965

Dr. E. P. Hayward
197 West Chestnut Street
Kingstm, New York

Dear Dr. Hayward:
Thank you very mach

for your invitation to visit with you,

Nayl, orSmdsy,Hay2. WhlwillbsinﬁewYor-kattmt
Imadxsdulsdtoattsndmdpz‘essntmpomsstthomtings
tin,
of the Society for Biological Psychiatry. It mid not be possible
to leave the city on either of those days.
Honour, while I plan to attend sessions of the Mariam
Psychiatric Association during the week, I an ms to visit
Kingston 'mssday afternoon. leaving the city about mm; or
my time Wednesday.

for your invitation mad I trust that it will be
possible to visit with you at either of those times.
Thank you

Sincerely yours ,

.

Max

Fink,

M.

D.

Professor of Psychiatry

111’sz

�</text>
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                    <text>January

2...,

:1,

«.1

—.~

16 . 1967

Miss Connie Hicman
Computer Center
Missomr'i Institute of Psychiatry
51500

Arsenal Street
St. louis, Missouri

63139

run-mm:

Dear Connie,
75,‘Fr:b-W"WWIW"

cw;-

-&lt;

vm.

fm

Dr. Denber which asks a
Enclosed is a letter
question which can only be answered by checking the tapes
available at the Missotmi Institute of Psychiatry. I
know

that you have twoapes which I have asked

hold which contain the cyclezocine data.

'

you

to

mvm»:mr«

v—-

ww‘ca—

N'"

raw

r
”‘7'":

In addition to these, are there any other tapes at
the Oanputer Center derived frcm Dr. Denber's study?

I look forward

regards.

“sr

to seeing

you

in

New

York.

My

best

Sincerely yours ,

1

g
m

-‘"’m"."

raw-c

Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬂcp

cc: Dr. Denber

:_

A

M

F.

I”?

�</text>
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                    <text>Fem-y

2, 1967

Miss Connie Hickman

c/o Camuter Center
Missouri Institute of Psychiatry
51400 Arsenal Street
St. Louis, Missouri
DearComie,

It was nice

seemgyou again in St. Louis.

IhevelookedattheCDT-Emmeterialandthelistofitans
from the
rating scale. When Dr.
end I checked the items
against one of our rating scales, the numbers
and the titles
generally matched, but there were some discrepamies.
Since
is very important that the individual behavior be
correctly
matched, I have asked Dr.
to ask Dr. Holden to go over
this with you.

Itil

it

Itil

Please pull out

some

of the sheets that

you
to punch
thedetaandsmtchecktoseeiftheitemsarecomct.
When
you are done
Dr.

checking,

numbers and items

carefully.

titled

used

Holden should have a list of correct
I can go over the material

so that

Secondly, I had picked up the two.
Denber tapes
from the canputer room and took them toadditional
Dr.
office,

Itil's
neaningtotakethemtoNewYorkwithme. But,
Iforgotto
takethem.

Imuldbegratefulifyouwouldshiptlmntom.

Many thanks.

Sincerely yours,
Fink, 14.1).
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>December 16, 1966

Miss Connie V. Hidonan

Camutsr Center

Miami Institute of
suoo Arsenal

Street

St. Innis, Missouri

Psychiatry

63139

DearOonnie,

'3. Fortmntely,‘

vcdthc
Wahavefinallymceivcd

'

terandial
mddidso,1argelyfmm
Iradmlympmsentthsmtsr

manory.Nthavetowitcthopaporandwi11beab1etoput

ﬁrsaohnlnmberaintcﬂmewctdraft. mopapersazrivedin
had given
satisfactory condition. Ibuwsr,asIrHtoo11e,Don
ttersfrantheTims/Data
unsandlatt
maneuvelcpecmtainingmlletms

theEEGreooxds sothatI
ticn. Iptrtthsmonthctopofthe
wwldmtravetooanytmfolder.1ncpeningtmmmxldonot
wastakmout and,ifso,
’findthan. Perhapsbofmpaddmthiswas
wouldywpleasccmckyumtable?
Hy best wishes for aMarry atrium.

Sixmly yours,
Max

Fink, NJ).

Profeswr of Psychiatry

MF:kp

�December 16 , 1966

Miss Connie V. Hickman

leputer Centw
Missouri Institute of Psychiatry
SnOO Ameml Street
St. Louis, Missouri 63139
Dear Connie ,
We

have

finally received the cyclazocineﬁﬁmw. Fortunately,

Ihadmlytopmsentthemterialanddidso, largelyfran
toput
mam. Nwlhevetomitethepaperandwillbeable
treactualnmnbers intothenextdmft. Thepapersmivedin
Don

had given
However, as I recollect,
Time/Data
from
and
the
letters
mlletins
containing
an envelope
Corporation. Iputtrmonthetcpofthemmcomssothatl

satisfactory condition.

me

wauldmtlavetocarrythefolder. Inopeningtheboxldonot
taken out
find them. Perhaps before packing this
table?

would you please check youm
My

best wishes for a

may

was

Omismas.

Sincerely yours ,
Fink, M.D.
Professor of Peyclﬁetry

Max

MF:kp

and,

if

so,

�</text>
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                    <text>October 28 , 1966
Miss Constance Virginia Hichmn
Couputer Center
Missmmi Dustitute of Psychiatry
51500

Arsenal Street

St. louis,

Miami

»

-

63139

DearCormie,‘
mom.

Kathytoldmofthetapeproblem. Iheartilyexpeoted
Idomthaveamthergoodtapetosendyou. Iam

makingmangmmntstobeinSt.LouisonNovemberllarx112,
andmuldmébepleasedifloouldgooverwhateverywhaveat
thatt .
brought the barbiturate study material and this
seened very good. He has some suggestions as to the next
Don

stepandpmbablyhasalreadydisoussedthiswithyou.
WemtinWasMngtontogoovertheDenbernaterialam
wehaveaskedDr. Bomtotosendsomeofthebehavioraldata
to St. Louis, When it arrives it will be in card format and
thesamekindofanalysisthatwasdone fortheEBGsauples
will probably be done for this data; weaver, it would be
helpful to see a listing and perhaps a simple print-out should

first be prepared.

firal draft of our presentation
like "aannie" better than "Constance" "
until you authorize otherwise, it will remain as "Constance.
Homver,youwill stillhaveachanoetodmangeit, asIexpect
Enclosed

in Madrid.

is a

copy of the

While you

the galley proofs in a

few months.

I look forward to seeing

regards.

you

in mid-November.

My

best

Sincerely yours ,

Pm M.
m
Professor of Psychiatry
’

mfkp
P.S. Aseoondoopyésenclosddfor Don.

D0

�</text>
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                    <text>December 8 , 196“
Miss Susan E. Higgins,

Editorial Assistant
c/o Professor P.

B. Bradley

The Medical School
Birmingham, 15, England

Dear Miss Higgins:
Your letter of December 3rd crossed a package of
reports submitted from St . Louis to Dr. Dieter Bente. In
that package we suhnitted the oanmmioations from Dr. Gershon,
Dr. Ulett, and Dr. Itil. Sone weeks earlier, I had sent on
to Dr. Bente aﬂaoopy of my report and the smunary of the
discussion of section 2.

day,

Dr. Ul‘ett's discussion on Section 2, the second

wasasmmnaryofareportthathaselreadyappearedin

press and I do not believe that he wished to have the material
published anew.
While I can send you corrected copies of each of
these reports, I would prefer to take the liberty of sending
a copy of this letter to Dr. Bente with a request that he
either send our package on to you, or indicate to ne mat he
has not received the neterial.

I will, however, send you copies of my presentation
and the report of Section 2, as these were not sent to Dr. Bente

afewdeys agoandtheyverywellhavebeenlostinthemail.
Sincerely yours ,
Max

Fink,

Director

mf;ls

M.D.

�</text>
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                    <text>May

H.

15525

23. 1963

Division

Chicago 21,

Illinois

Dear Mr. Hilam
At a vacant visit to the laboratories of It". Eli Robins
Washington University. he recommded a flaw: ptntamter
made by
I would
mocking literature
this instrwmt. as well as any othem provided
by this. cow-any. and a price list.

a!

[him

Wing

meant:

Thank you very me)»

Sincerely

Khan

yam.

”0
m
M.
Water

DI

�</text>
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