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                    <text>wow»

L-r'WJo-

”MA

.n

NW”.

Mﬂv‘uwviw:

W

,

.vnr.1'm

Jmuazy 16 , 1967
Dr. M. Kletzkin
Department of Pharmacology
Wallace Laboratories
Crembmy, New

Jersey

08512

Dear Milt,

for the bibliogaphy on Carisoprcdol. It is
that most of the mlevant data is published in the
New York Academy of Science's volume and I have requested
this from the library.
I have also received from Dr. Sampson a smmary of the
experiences with tybamate. From our discussion in reviewing
this material, I am even more interested in the possibility
of using either compound in the witlﬁrawal period.
Would it be possible for your laboratory to make available
to me a copy of the Academy of Science's volume of 1960 and
Thank you

obvious

also the

1959 review

edited

by

J Miller?
.A

Manythaﬂcs.
Sincerely yours ,

is; Pink,

M.D.

Professor of Psychiatry

Mf‘ﬂq)

�</text>
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                    <text>“my-

”pm,

—.—

"NA”-r-

,

y»-

r
.
....

January 16, 1967
Dr. Martin

.C.

Sampson

Vice President - Medical Affairs
Wallace Pharmaceuticals
Cmnbury, New Jersey 08512
.

Dear Dr. Sampson:
Thank you very much

for the information

you sent me

regarding tybamate. Dr. Kletzkin of your Department of
Pharmacology had already sent me some information on
another of your conpoxmds, CarisoProdol and I am quite
interested in using one or the other in a special application in our laboratories.

grateful if

call me and
we had an opportunity to discuss the possibility of
using either compound during the period of withdrawal
in narcotic addicts.

I

would be

Dr. Rath would

.

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MPﬂcp

�</text>
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                    <text>Jamary l2 ,

1967

Dr. Martin A. Green

2035 Lakeville Road
Park, Ned York

New Hyde

Dear Martin,

FortoomnyyearsIravebeenewandewogelandso,
enjoyed the letter you sent me. What was omitted, however,
enjoys his trips and
is that for a time, the wandervogel
so gets a gratification which is not spelled out. I am
afraid in today's climate
ym.

it will continue.

Incidentally, enclosed is an article which

'

may

interest

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>January

12

, 1967

Miss Ruth Norton
York Medical College
Flower and Fifth Avenue Hospitals
Fifth Avenue at 106th Street
New York, New York 10029

New

Dear Miss Norton:
The goal

of the exhibit

is to state that:

l.

Teclmiques

2.

These changes bear distinct relationships

the

exist for measuring changes in

human EEG.

to the behavior of psychiatric patients.
There are few quantifiable measures in psychiatry which
are related to behavior. Many efforts have been made to
study blood pressure response, heart rate, speech and to
relate these to mental states of patients. Each of these
methods have been difficult, partly because the measures
themselves were difficult to quantify and the relationships to behavior were :iélusive.
Brain function, however, is mirrored by the
changes in brain function appear so be directly

EEG

and

related
tobehavior. Forexample, ﬁtteEmshavsadungemtm
direction of a slowing of the frequencies this is almost
always accompanied by relaxation, a decrease in anxiety and
tension and an improvement in psychotic thinking. If, on the
other hand, the EEG shows changes in another direction (called
-,

desyncrmonization) this is often associated. with increased
psychotic activity, increased anxiety and a clinical worsening.
In

this demonstration we

would

like to exhibit:

l.

The

2.

Data from studies showing the relation of
changes of EEG: to changes of behavior.

'

actual quantifying measurement of the

EEK-3.

�Miss Norton

-2-

January 12, 1967

_

WeMpetodothisbyanactualdemmsmtimofanmulysis,

an exhibition by charts of the. data of studies , presentation
of documents describing previous studies and by having questions
answered by my associates and myself.
‘

Attached are two papers that summarize (unfortunately in

scientific

law) the point of view that

I

grateful for your help.

present.

would be

we would

Sincerely yams,
Fink, M.D.
Professor of Psychiatry

Mm:

like to

�</text>
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                    <text>January

12 , 1967

Mr. Richard Wexler
Manager, Technical Marketing

Tim/Data Corporation
801 Charleston Road

Palo Alto, California 9u303

Dear Dick,

I have completed my arrangemnts for the trip to
California. I will be at the Fairmont Hotel and
attending
meetings Saturday, Sunday and Monday.- I will try to call
you early Monday morning to set up a date Tuesday morning.
Donwill not be with me.
,

Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>January 10 , 1967
Dr. Werner P. Koella
Worcester Foundation
222 Maple Avenue

for Experimental Biology

Shrewsbm'y, Massachusetts
Dear Werner,
Enclosed are two xerox copies of our report on cyclazocine
at the American College of Neuropsychopharmacology
San Juan in December. I have been dissatisfied with the

as presented

in

figures.

thought,

figures.

SincetheydomtaddasmchasIhadwiginally

I stould like to

Thank you

submit

this for publication witl'out

for your patience.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 10, 1967
Dr. Robert B. Anderson

Early Clinical Drug Evaluation Unit

Psycl'ophamacology Research Branch
NatiOnal Institute of Mental Health
Bethesda, Maryland 2001a

DearBob,
Thank you very much for the forms which I received
today. They are most helpful. I note that Part III of
the drug study patient record has been set up for Optical

page reading. I am delighted and will
forms into this format. Many thanks.

try to get all our

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MFﬂcp

�</text>
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                    <text>January 10 , 1967
Dr. Joseph Bird

Sterling-Wintm'op Research Institute
Renaeelaer, New York
Dear Joe,
Enclosed are draft copies of the reports of the
secondary effects of cyclazocine and our EEG sumary.
The secondary effects data has not been submitted for

publicatim; theEEBmaybepubliabedbytheAmrican
College of Nempsyohophamaoology.
Thenk‘you for your

'

interest.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max
MF:kp

.

,

�</text>
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                    <text>January 9, 1967
Dr. Thomas A. Ban

Douglas Hospital
6875 LaSalle Boulevard
Verdun, Quebec
Canada

Dear Dr. Ban:
Thank you very much for your notification that I have
been elected a founding member of the C.I.N.S. The notice

of October/November 1965 indicates that a draft of the
constitution will be attached. I have not received such a
draft and would request a copy if one is still available.
Sincmely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>January 9, 1967

Director
New
2

York Academy

of Medicine

East 103m Street

New

York,

Dear

New

York 10029

Sir,
for your kind invitation to an open
I look forward to attending and meeting

Thank you very mach

house on January

the ﬂouncil.

2%.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

.

�</text>
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                    <text>‘
&lt;

'

January 9 , 1967

N'H'“

”emu-mu»;

,Wxnw.

V

&gt;

Dr.

J.

C. Holden

M.

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Mike,

It wil 1 be a pleasure for me to participate in the next
C.P.A. meeting to discuss your report on LSDand Ditran.
Thank you for this opportunity to remain an cement with
your

work.

.

told you, we discussed the CDT
have
to
to ask for the Stggested revisions which
he has made and I will then devote much time to some
suggested revisions of the earlier draft you have sent
as well as attempting to incorporate the EEG material. ,
I have received the corrected laboratory print and will
have taken them to the editor personally 0:31 Monday.
'

As Turan must have

mteriel in great detail during his last visit. I
him
written

What

is the status of the are material?
Sincerely yours ,
Fink, PM).
Professor of Psychiatry

Max

‘

MF:kp

�</text>
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                    <text>January 9, 1967
Dr. Tumn

M.

Itil

Missouri Institute of Psychiatry
SMOO Arsenal Street
St. Iouis, Missouri 53139
Dear Turen,

I have received the material for the clinical laboratory
paper and will have, by the time you have received this letter,
taken the material to the editor. I have also received your
kind hvitation to be nominated as a discussant of your suhnitted
paper for the CPA, and accept gladly.
'

Dr. J. Roubicek of Prague has been canmnicating with
Dr. Freedman for a number of years. In his last letter, he
indicated that he and two of his associates would be seriously

interested in coming to New York for a two year period, to
undertake and participate in a study program in schizophrenia.
The protoccl, a. copy of which is enclosed for your consideration,
is so remarkably like the program MH—ll38l, that I am stimulated

to send this to

you

for your critique.

.

are going ahead with the develOpment of a relationship
with Manhattan State Hospital and with the Department of Mental
Hygiene of the State of New York to establish a study unit for
the patients who are wansferred from the Metropolitan Hospital
Carmmity Mental Health Center to a long tem facility. This
facility will be designated as a Specific unit and bear, we hope,
close achninistrative and scientific relationships with the
Department of Psychiatry.
We

_.
.r

,
is.

V

7..

..

e
.

_.,,_.u..(:.,7_..e

—

,2”...

.

,7
V

)

“at,

w“

,'_!"if!h!‘-'1T‘-

—rn

17,-:

is.”

ran»

With this program in mind, the protocol of Dr. Roubicek
has become of specific interest for
provides a reasonable
framework for the establishment of a long range study. As I
read the notes, I believe that our study progran “Ii-11381)
is considerably more advanced than this protocol, and may
provide the basis for a collaboration between ourselves and
Dr. Roubicek within the frmmwork of a new unit.

it

Imuldbegratefulifyoumildtakethetimetoread
we can discuss them on your next
visit to New York.
these notes and perhaps,
’

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MP:kp

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  <item itemId="2687" public="1" featured="0">
    <fileContainer>
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                  <elementText elementTextId="102105">
                    <text>January 9, 1967
Dr. Richard Abrams
10” Childress

Sheppard AFB, Texas 78311

Dear Dr. Abrams:

I have discussed your request with Dr. Preednan and Dr. Kaplan
have reviewed the experiences you have already had in
relation to the study progran in the Department. I am pleased
and

z-a'

z.

:

ﬁﬂﬁww-vﬂ!

we

thattheChaimanhasbeenabletoaffirmthatastudypmgzun
should be

latter portion of your training.
months the initial assignments will

undertaken during the

«rum-1,2-

.
:9
_

Deming the

first

few

be made in those areas in which you lack specific experience
as narcotic addictiOn, the mental hygiene clinic and child
psychiatry. As soon as these are accomplished in a satisfactory
fashion, we believe that the study program you have outlined may
be undertaken.

critical part of the study is in the development of
EEG patterns with unilateral ECI‘.
I have read the
Zamora article and am mimpressed. I have requested the Martin
article but have not yet seen it. Surely, your om experience
becomes very critical and I wwld suggest that you outline the
observations which you yourself have made regarding the EEG
differences with unilateral and bilateral ECT. Especially, if
The

different

_

you have samples

of the records in subjects treated with unilateral
clinically and comparing these with other

ECI' showing improvement

subjects of approximately the

bilateral BCT.

same age

stoning improvement with

In reading your protocol of December 6 , the introduction
so is the hypothesis, Imam, of the
four alternate ezqalanations, the fourth is unclear.
The first

is straightforward and

three are quite good.

"‘5"?

,HCTAFWF-thwhm"!

'I'hemethodisrelevmtandImuldonlyaddthattheEEG

delta activity is to be recorded following

ECI' at a specific time,
hours. Your suggestion of the determinatims of
CSF acetylcloline and chinesterase is a good
one, but this may
be the most difficult part of the study to acoanplish.

probably

aways-1y,»

mm:

~1sz

_

,
‘

V

W

’2"?!

9
-.-

times»

Few:

was:

NWT):

2n

�-2-

Dr. Abram

~

January 9, 1967

_

At our last meetiru you suggested that you would like to
collect the literature relevant to this problem. The citations
which I have listed at the end of my. few reports are those that
appeared to me to be most relevant. Surely, by checking these
one can obtain the citations to many other articles which,
perhaps should be in your library. If you wish, I would suggest
thata the next opportunity for you to be inNew York that you
visit with me and we can go over my collection making such
notes as may be necessary to provide you with the basis for a
literature review. I have not carried out a systematic survey
of ECI‘ literature since 1959 and perhaps an alternate solution
would be to check through the major indices for literature and
ask for the articles which may have appeared in journals not

ordinarily available in the major

I

am

delighted that

this study program.
Good

we

New

York

libraries.

will have an opportunity to undertake

luck in your present programs.
Sincerely yours ,
Pink, M.D“v’
Professor of Psychiatry

Max

ME‘:kp

�</text>
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  <item itemId="2688" public="1" featured="0">
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                  <elementText elementTextId="105408">
                    <text>January 5, 1967
Mr. Donald B. Cheetham,

Research Associate

Jr.
-

Clinical Investigation Department
Smith Kline and French laboratories
1500 Spring Garden Street
Philadelphia, Pennsylvania 19101
Dear Don,

of Psychiatry of the New York Medical
College—Metropolitan Hospital Center is establishing a
laboratory for clinical psychophamacology in the adult
mental hygiene clinic. As part of the operations of this
, the
clinic, both for treatnent and for training purposes
Since
would
most
be
helpful.
of
placebos
availability
Thorazine is the most cannonly used psychoactive agent in
this clinic, I would like to request supplies of Thorazine
placebo be made available. The two stengths that are. most
cannonly used are the 50 mg and 100 mg tablets.
The Department

'

of

.

be possible to supply us with 5 ,000 tablets
it
each for 50 mg and 100 mg equivalents?
'Ihorazine
Would

placebo

to the proposed NAD study by Dr. Itil, I
told him of our conversation and he will
have called
contact you directly.
Thank you very much for your cooperation.
With regard

him and

‘

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

‘Mszp

‘

�</text>
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January 5 , 1967

«~.-

I—."/“

“gnaw-«av-

4"

new»:

7-.

uric!

Dr. 10.118 A. Gottschalk
Department of Psychiatry
Cinchmati General Iiospital
Cincimati 20, Ohio
Dear Lou,

I hsve received and read with a great deal of interest
your study of brief psychotherapy. The conclusions appear
very reasonable and this report is exactly the kind of basis
for study which our clinic may find very useful. I have sent
this on to Al Freedman with a recommendation
that it become
a starting point for a study group.
Thank you very much

for sending this copy to

congratulations on a very useful report.

me

and

Sincerely yours ,
Fink, M'.D.
Professor of Psychiatry

Max

MP:kp

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                    <text>January 3 , 1967

Assistant to the Director
National Library of Medicine
8600 RockVille Pike

Bethesda, Maryland 20014
Dear Sir:

grateful for capies of the pilot issues
of the Bibliogaaphy 05 Medical. Review , recently published
by NLM and as described in a recent issue of Science.
I

would be

Thank you

for your cooperation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MI-‘zkp

�</text>
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                    <text>January .3, 1967
Dr. Donald M. Shapiro
Washington University
Canputer Center
Sever Hall
Lindell and Skinker Blvds.
~

,

St. Louis. Missouri

63130

DearDon,

I am pleased to oonfim that I have appointed Miss Gail
Gleasner as pro
r in the new study program in New York.
Miss Gleasner Will be available to assist in the translation
of the 1710 programs fer the IBM 1800 for the demonstration

attheAPAinMay. Iwouldbegratefulifyouwouldmakethe

necessary arrangements for her to work at Washington University
during the next few months. I believe that she will be
available for a number of weeks at a time.
As we discussed, the need is for the «operating program
be
to translated so that we cmld put on a demnstration using
sane of our; taped records. To the extent possible,
may be
'

'

it

helpful for her to observe the operations of the EEG. laboratory
at the Institute and I would be grateful if you would make the
necessary arrangements with 'Iuran during her visit.
soon as I have a date available form to cans to
St. Louis, either Kathy or I will call you.
'As

‘

My

best regards for

the‘New Year.

Sincerely yours,
MEX

PM,

Mon.

‘

Professor of Psyd-niatry

Mchp

as: a...

.

“v.

vw‘.,‘4n

11:11

�</text>
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Mp
W1:

11'. Walter

02mm, (3131an
(laminae

13.

America IEBGfSociety
0 Psychiatry

WWW

School of
Durhm. North Carolin:

Duke

Maine

Dear Walter,

Iuwldlﬂcetomoumndnr.m1tilfwmmhip

intMMricmEBGSociety.

Immaaormmm

1958,;21dmpleaudwimhedeMmoatmuismi

mama of Psychiatry

in 1963.

Hofeswinﬂnkpwtmm
meannmismte
ofWatﬂnUrﬁmsityofMiamH-imdimof
At

mimmrmamainimlmmvprysiomattm
mimmSocidtymﬁmawingthepntfmmand
ammofmmwsmiclesmﬂnoubject,1balm
hcumxldboavalunbloadditimtoﬂnmmhip.
MiamimstimofPsychimy. Hennwmrimatom

mama for WW 1*pr,

Encloaodisacopyafhismiculmvim. Iftharc

are any additioml

Iwillbopmud’oocaxwthuamt.

Hyhustpmnlmwds.
511ml}!

mm.

Pink, 3.3).
Professor of Paydziatry

Max

WP
on:

m». Taxman.

Itil

�</text>
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Dr.

m

December 22, 1966
H. 11:11

Missouri Institute of Psychiatry
suoo Arsenal Street
St. 10113, Missouri 63139

Deu'mrun,

Winﬂngalleyofﬂnlabomtorytestpaper.

Would

ymandﬂihepleasegomitmmkesuchadditiomlmectiona
umybeneoeaaary.
Please as): Mike specifically to duck Table

refmnes.

II for the text

_

I mild like

200

reprints withcovers andwuld suggest that

ywozdersoomermgemewithanypmimorallofit.
Sincerely yours,
Fink, PM).
Professor of Psychiatry

Max

Mfﬂcp

�</text>
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                    <text>bomber

22 , 1966

Moscow Heinrich mﬁver
mecasor of Psychology

Division of Biological Sciences
University of Chicago
Chicago:

Illinois

60637

Dear Professor ﬂavor:

Itwasagmatplcmtotnaryumpmmtatimattm
AmericanCoﬂegechunopaydchgarﬂyamwceptm
cfmanbershipmedus. Implmedtoravehadan
tytcmviwoneofyoxmpapemmd,followmgmm
discussion,amsendingycuoommprintcopieaasﬂnoem

sentbythejourml.

.

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>_.

.
.

r
a

-

A»

:

:
was,

r

Dow 22, 1966

«2.;

«u-

wow.

Dr. Joseph a. Bird
Sterling~WintMup munch

var-9

any

which:

Rancher,

games;

1"!

New

York

Institute

Dear Joe,

_

Itwasvezykixﬂofyoutormanbermatthistm.

k5137'zW-1'J-‘Vw'mm.

7

childmnhavealmysenjayedopeningpackagesdelook

fmtotakmgthisranetonightmdmmiamgﬁm.
Sincerely yams,

r'

.-~m:'»":,:r

Amx'nzrlzl‘wln

Max

'1)“.

A

ryr-r-W

Frugal.

lynx“:

zf14.".j‘:,l

_-

)4
‘1'.’

LA'I’v_-4ﬂ...‘i"l‘."'

:v
x.
.v

1-1.»!

..

2w"

eg
351-.—

_

I77

Fink,

M.D.

Professor of Psychiatry

W.‘(:.:‘Mnyy{/.V

Wzkp

My

�</text>
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                    <text>March 29, 1967

Dr. Alain J. Sanseigne
Associate Medical Director
The Squibb

New

Institute for Medical Research

Brunswick,

New

Jersey

08903!

DearAlain,

I very much enjoyed the opportunity, once again, to
discuss the fluphenazine projects. Following our discussion,
I have made up a protocol entitled "Treatment of Schizobimenia

with Fluphenazine: High Dose and Very High Dose Therapies. "

Ihave sentthistoDr. Itilforhiscannentsandassoonas
I have received these, will send them on to you.

The first fluphenazine decanoate data is ready to be
into
put
folders, except for four additional smuaries. As
soon as these are carpleted, all the material will be sent

toymandshwldbeinywrhandswithintwomeks.
Sincerely yours ,

Pink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>r

March 29 , 1967

”1:4”...va

w

;

E-

E

E

i

g

:
E

J. Worﬂxingtm
Street
51012
Iowa
crumbs,

Dr. John

802 Walnut

Dear)». Worthington:

Wehavereoeivedaoopyofyamcm'zdculmvitaefmtm

'DothanlbyAssooiates. 'meChaimanoftheDepar'mnnt,
Dr.A1fmdM.PreednmandeillbedttMAPAmﬁngsin
Detroit. Ifymplantobetrm,1wouldbepleasodto
mangetometwithym. Iwillbestaymgatthelbtel
Pomlm'train

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

F
3

MF:kp

cc: Dorothea Bmlby

�</text>
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                    <text>March 28, 1967

Prof. Dr. A. Herz
Max-Plandc—Institut
..
Deutsche Forscmngsanstalt fur Psychiatrie
Kraepelinstrasse 2

‘

Munich 23 , West Germany

Dear Professor Hers:
Thank you for your kind invitation to participate in the
support of a new journal "Pharmakopsychiatrie - Neuro-Psycho—

It. would

be an honor to participate in the
journal, especially one whose title is so
close to one that my associates and I have discussed frequently
during the past few years. I am pleased to accept your
invitation to submit a report of our studies.

pharmakologie. "

launching of a

new

As you know, I have been interested in a number of aspects
of neurophannacopsychiatry, including the theoretical issues of
the reﬂtion of brain changes (EEG) to behavior with drug
treatments and ECT, including such special problems as the
identification of new drugs and of drug sensitive populations.
We have also actively studied the practical issue of the best
way to quantify the changes in the EEG using digital computer
analytic methods and the best way to quantify behavior, using
item analysis with rating scales. To assist me in selecting
an appropriate representation of these studies, would you let
me km»: more of the oozrposition of your editorial board (anyone
from the U.S.?) or, is there a statement of policy already

enunciated?

Sincerely yours ,_,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March 27 , 1967

Dr. Victor M. Victoroff
Associates in Neuropsychiatry
2231 Taylor Road
Cleveland 12, Ohio

Dear Dr. Victoroff:
Thank you for your referral for LSD treatment. The LSD
treatment and study program was undertaken in St. Louis in
1962 and was available to long term mentally ill only. There
seemed no justification for therapeutic trials with LSD in
others, since other treament methods have generally been

efficacious.

Since moving to New York in June, I have not re-instituted
an
treatment program and so cannot offer one to your patient.
We are however, interested in
subjects who have not responded
,
LSD

to other treatments (as I assume is true for this patient) and
are actively engaged in testing a variety of novel therapeutic
agents , especially in patients with a history of non-responsive

depression.

If your patient may

be interested in participating in such
a treatment program, I would be pleased to review a sumnary of
her case history and to advise you as to the suitability of our

methods.

It was kind of you to think of us, andmy associates and
I wish to thank you for your omsideration.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March 27, 1967
Box 26235

New York Times
151$? Broadway
New York, New York

Dear Sir:
The Department of Psychiatry of
embarked on the development

recently

this Medical College has

of a computer facility
focussed on the problems of the analysis of physiological
signals . For this purpose, the laboratory is being equipped
with an IBM 1800 system. It is anticipated that the College
will, within the next eighteen months , expand their present
computer

V

facility to a larger unit.

-

The equipment for the Depmnt' 5 computer center is
to be delivered during the first week of May. We are now
appointing pmgrarrmers. This will be a small laboratory,

consisting at

your

Ext.

its

staff members.
If this opportunity interests you, I would appreciate
calling my secretary for an appointment at 369-7900
2147.
naximn of 8-11

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

M'r":kp

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                    <text>\1

March 27 , 1967

Dr. Ttman

M.

Itil

Missouri Institute of Psycl'datry
5&amp;00 Arsenal Street
St. Louis, Missmri 63139
Dear

Men,
Again, I must tell you how umch we enjoyed your
we accomplished quite a lot and I look forward

think

visit. I

to visiting

after the California trip.
First , I have read the TRP drug evaluation study protocol

with you

dated 3/8/67 which you asked

me

to check.

The study design

is

straightforward and I found no significant objections. Since
I am particularly interested in the rating, I paid attention
to the section on page seven. This schedule of rating is
satisfactory, with the only proviso that every effort shwld
be made to have the ward nurses rating the patients be the same
nurses for each group of patients, wherever possible. I believe
the patients will be on more than'one ward. In the same fashion
that you are asking the same physicians to rate each patient
throughout the study period, perhaps the nurses should also be
named and an effort be made to identify those who accept the
responsibility for the ratings of this study.
'

Enclosed is a retyped protocol for the very high dosage
fluphenazine study, projected for Istanbul. If this is

satisfactory, please call

I

pleased

me

and

Ilwill

send out the

original.

have read the laboratory paper again, and am just'as
now as I wassane months ago. I am not clear whether

v

�Dr.

Itil

-2-

Mardh 27, 1967

that I should send copies to each of the BCDB investigators,
orwhetheryouwould. IwmldbegladtodosoifyouandMiJceapprove.

we

agreed
My

best regards to Ellen.
Sincerely yours ,
Fink, M.D.
Professor of Psychiaty

Max

MF:kp

P.S. I have just read the booklet on psychiatric and clinical
rating scales once again. It is most useful and an
excellent idea. May I suggest that you add a specific
item identified as 1A or as number 8, in which the Turkish
nodification of the rating scales are included with a single
'

stating that the translation was made for
a specific project , but that the principles are applicable
to other collaborative study programs.

page description

Either with this addition or without it , would it be
possible to supply me with three additional copies of this
publication #2 (1967)?
Many

thanks.

�</text>
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                    <text>March 27, 1967

Dr. w. P. Colvin
Medical Departmnt
Burroughs Welloome and Co. , Inc.
1 Soarsdale Road
New York 10707

'Iuckahce,

Dear Dr. Colvin:

It was a pleasure to visit your laboratories last 'I’lmrsday
to revive the nemries of my earlier studies of Kemadrin. I
trust the afternoon was as helpful to you as it was interesting
to me. In the event that it is decided to investigate Kenadrin
as an antidepressant, I would be pleased to discuss such a study.
and

As I mentioned, we are embarking on a long-acting depot
phenothiazine study, assessing the clinical efficacy of
fluphenazine deoanoate in the treatment of schizophrenia. For
this study, we would appreciate meoughs—Welloone making supplies
of Kenadrin available for the study patients. It is anticipated
(see enclosed protocol) that the patients will receive injections
once every 7-21 days with the majority receiving injection at
weekly intervals. They will be enowraged to keep a supply of
Kenadrin at hand at all times and to take 1-4 tablets daily, as
may be required. For this purpose, we believe that Kemadrin in
wall containers usually supplied physicians as samples of
"Ehpirin Oanpomd" may be most helpful.
.

to provide tablets of Kenadrin (5 mg)
led it be possible
20
for a total supply of 5,000 tablets?

in sample lots of
Many

(“2214)

thanks.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mfzkp

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                    <text>March 27 , 1967
Box P119

York. Times
1547 Broadway
New York, New York

New

Dear Doctor:
During the past few maths, we have developed a study program
in a camnnity mental health center dedicated to an unders
of the problem of narcotic addicts. While the principal emphasis
in the program is in the pharmacology and psychology of addicts
and the treatment of their emotional disease, the physical
concmitants of their illness have become an important interest.
,

In the continued development of this program, we are seeking
the appointment of a physician with an academic background who
may accept the responsibility for the direct medical care of these

patients.

'I‘hestudyprogzmisintheDeparmentofPsychiatryofthe
- Metropolitan Hospital Medical Center.
If this Opportunity interests you, I would appreciate receiving

New

a

York Medical College

copy

of your curriculum vitae.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MFﬁcp

�</text>
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                    <text>March 27 , 1967
Box 214832
New

York Times

15% Broadway
New York, New York
Dear Sir:
The Department of Psychiatry of
recently embarked on the development

this Medical College has

of a computer facility

focussed on the problems of the analysis of physiological
signals. For this purpose , the laboratory is being equipped
with an IBM 1800 system. It is anticipated that the College
will, within the next eighteen months, expand their present
computer

facility to a larger unit.

The equipment for the Departnent’s canputer center is
be
to delivered during the first week of May. We are now
appointing programmers. This will be a small laboratory,

consisting at

its

maximum

of

8—11

If this opportunity interests

your calling
Ext. 2H7.

my

staff members.
you,

I

would

secretary for an appointment at

appreciate
369-7900

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

'

�</text>
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                    <text>March 23 , 1967

Dr. Daniel Silvennan
269 South 19th Street

Philadelphia 3, Pennsylvania
Dear Dan,

Surely, the problan

is of sufficient general interest

to warrant repetition. I can

do my best to present the
material as presented in Denver. If the other participants
would be willing to give you a projected date for the
manuscripts, I will tell you what my own schedule is and
do my best to met a comm date.
My

best wishes.
Sincemly yours ,
Fink, M.D.
Professor of Peychiatzy

Max
MI-‘:kp

�</text>
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                    <text>March 23 , 1967
Boo:

83376

New York Times Brooklyn
15%? Broadway
New York, New York

Dear Sir:
Your advertisement in the New York Times is of interest
The Department of chhiatry has recently embm'ked

to us.

a series of new pmgrans as part of the development of a
ounmnity mental health center. These prograns require delt
in evaluations of the treatment results and methods. We
are interested in appointing social scientists with different
badggmmds who may be able to contribute to these studies.
on

I

would appreciate receiving a cepy of your miculwn
and the opportmity to meet with you. If this is of
interest, please call my office at 369-7900 Ext. 2H8.

vitae

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf'dcp

�</text>
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                    <text>March 23, '1967

Messrs.

M.

Green and B. Finley

Experimnts Unlimited
9149

New

West End Avenue
York, New York 10025

Dear Messrs. Green and Finley:
Your

letter of March

2

was

sent to

me

for reply.

The

Department of Psychian‘y of the New York Medical College
has no study program at the present time for which
volunteers are needed. However, study program in the
use of new cmpounds are now being launched and volunteers

willbeneededattheendoftheyear.
The

specific nature of the age of the volunteers will

love to be determined by the studies themselves , although
the usual projects require young adults between 22 and no
years of age who are not taking medications of any kind,

norhavedeaasoforperiodsuptoonenonth.

The study programs will be within the Departnent of
Psychiatry and the responsible would be myself.
When you have developed this interesting service, I
would appreciate your continuing to keep me informed of the
means by which we can utilize such services.

Sincerely yours ,

W. Fink,

MOD.

Professor of Psychiatry

1%?qu

�</text>
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                    <text>Hard] 23, 1967
Dr. Phillip Bradley
The Medical School
Birmingham 15, England

Dear

Phillip:

Ithas beenmonths since therehas beenany activity
here with regard to the CINP volume. What is the present

status? Are the nanusmipts in final shape or in the hands
of the publisher or??

IsthemanytlﬁngIcandotobeofassistance?
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor. of Psychiatry

Max

MP:kp

�</text>
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                    <text>march 23,’ 1967
Mr. Richard Wexler,

mnager
Technical Marketing
Tine/Data Corporation
L$90

,

San Antonio Road

Palo Alto, California 9u303
Dear Dick,

I will

be in Oregon on April 10. I will probably attend
the sleep meetings in Santa Monica a few days earlier and
would like to visit with you, late on April 10 or early on
April 11. However, so as not to confuse us again, I would
like to wait until the week before and call you.

IfyourplansamtobeinNewYorkatmytimeinthe
would

near future, I

to call.
My

be pleased

to see

you and do not

very best.
Sincerely yours,
Max

Firﬂc, M.D.

Professor of Psychiatry

MF:kp

hesitate

�</text>
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                    <text>March 23, 1957

m'

T. P. 8. watts
Geigy Pharmaceuticals
Ardslay, New York

Dear Paddy,

m

you very much

arrived safely.
going

Dr.

to

far the supply of

ST~155 which

Simeonhasbegtmthe studypmgranarxiweamfirst
a small rating scale and then will begin

make up

the screening of patients.

Plantocaneandvisitus inafewmeks.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

�</text>
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                    <text>March 23 , 1967
Mr. Wali Dad

2191 Souvenir Avenue
Montreal 25, mebec
Canada

Dearm.

Dad:

Thank you very much for
to review your application.

m letter the for the opportunity

laboratory is still undergoing develomxent and I do not
specific position opened to date. However, I would like
the privilege of keeping your application on file and writing to
you when such an appox'mnity presents itself. Incidentally, I
am no longer- at the University of Missouri and any position which
may be available will be in New York.
have

The
a.

Sincerely yours ,
Fink, M.D.
Professor of Psychiany
Max

Mszp

�</text>
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                    <text>March 23, 1967
Box 88376

New

York Times Brooklyn

151;? Broadway

New

York,

New

York

DearSirz}
Your-

to us.

advertisement in the New York Times is of interest
of Parchiatzy has recently embarked

The Department

oneseries ofnewpmgmneaepar'tofthedevelopnentofa
cormunity mental

health center. These
require delt
in evaluations of the treatment results pmgmns
We
and methods.
are interested in appointing social scientists with different
badcgromds who may be able to contribtne to these studies.

I would appreciate reoeiVing a copy of your auricular:
and the opporttmity to meet with you. If this is of
interest, please call my office at 369-7900 Ext. 2168.

vitae

Sincerely yours

,,

Fink, M.D.
Professbr of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 23 , 1967
Dr. Donald

M.

Shapiro

Washington University
Computer Center

Idndell and Skinker Blvds.
St. Louis, Missouri 63130

.

Dear Don,
Enclosed

is a

copy of a

letter I

have received from

Dean Clyde. I have no other details regarding the program
but assume that this might be a work session. Perhaps,
would be helpful for us to consider participating as he
will probably bring together most of the peeple whose work
you should lam.

it

Will you be available?
ment regarding the programs

If

so, should

we make any state—l

available or simply indicate that
the majority have been prepared in our sunmary of last year?
My

best regards.

.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Mardh 23, 1967

Dr. Dean

J.

Clyde, Director

Biometric laboratory
University of Miami
P. 0. Box 9175

Coral Gables, Florida 3312“

DearDean,
Thank you very much for your kind invitation to participate
in the seminar on computers in psychophamacology. The end of
April is a difficult time for us, but I have written to Don
Shapiro to ask wrether he would be able to participate.

to the programs, we sunmarized the best that
available fmn St. Louis in the publication which you
received a year ago. In addition, we have one progran for
library retrieval, and I think you have a copy of that. Are
these specialized pmgrmxs of interest?
With regard

we had

Thank you once again

for the kind invitation.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

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Mathatronics
257 Crescent Street
Waltham, Massachusetts

021514

Gentlemen:
We are interested in purchasing an electronic desk
calculator and would appreciate descriptions of your
equipment, appmcimate prices in New York and the name
of a local representative.

Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MP:kp

�</text>
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                    <text>March 22, 1967
Wang

Laboratories

836 North

Street

Tmbury, Massachusetts 01876
Gentlemen:

Wemintevestedinpmhssinganelectmnicdesk

calculator and would appreciate descriptions of your
equipment, appmimate prices in New York and the nuns
of a local representative.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

HP:kp

�</text>
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                    <text>March 22 , 1967
Mr. Seymour Weingar'ten

Executive Editor

"

International Journal of Psychiatry
27 East 62nd Street

New

York

New

York 10021

I am pleased to enclose a review of "Psychophysiology
at an Interface" by Clinton C. Bram as requested. It has
takenmeabit ImgerthanIechected, becauseIfoundthe

report

why

it

somewhat obtuse on rue-reading and began to wonder
was selected. Surely, there must be more inportant

omtributions than this one which warrant reprinting.

I trust this is satisfactory.
Sincemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 21, 1967

Dr. Eugene Laska
Computer Center

Research Facility
Rockland State Hospital
Orangeburg, New York
Dear Gene,

I have recently had the opportunity to review sore studies
with phenothiazines and noted a citation which is not available
to me. Is is possible to make a copy of your report ”Dose
Response and Bioassay for EValuation of Psychpharmaceuticals"
which was presented at the CINP available to me?
Don

Shapiro has decided to join the

facility at

New

York

delighted. The first programs for
the 1800 are still in the process of being debugged, but they
have promised delivery in early May so that with sane luck we
will be operational by the end of the year.
Medical College and

Many

I

am

thanks for your help.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 21, 1967
Dr. Thran

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
Enclosed are the three drafts of the trifluperidol paper
as of a year ago. At that time I reviewed the EEG material
available and found that neither the computer records nor the
frequency analyzer data lent themselves to analysis because
I could not discern a single pattern. It was at that time
that we examined the question of abstracting meaningful data
from the seventeen computer numbers.

I have the following computer analysis folders and
send them back to you when you wish:
Gerwitz
Sexton
Richardson

lO/27/6M

Gross

9/30/65
11/3/65

11/25/6u
3/25/65

5/7/65

Taylor

Tisdale
My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mf:kp

will

�</text>
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                    <text>Match 16, 1967
Mr.

Stanton Wheeler, Editor

Social Problems

maul—Saga Fomdation
230 Park Avenue
New York, New York
Dear Mr. Wheeler:

Mmymnﬂwagomyassociatesand! submittodcurmport
consideration for publication in Sadat Pmbzm .
"Social Chas and Prognosis of Schizophrenia" for your

We have not mardfrun yum office and muld appreciate
information regarding the decision (31' your mvims.

Sinmly yours ,
'

MP:kp

cc: Dr.

‘l‘uran

Itil

m
m, “to.
Professor
of Psychiatry

�</text>
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                    <text>March 16 , 1967

Dr. Alain Sanseigne
The Squibb Institute for Medical Research
Georges Road
New Brunswick, New Jersey
.

Dear Alain,

is a draft

copy of the summary information in the
deoanoate project. This contains only the
most important clinical informatim , for we are planning to submit
Enclosed

first fluphenazine

this to a general medical journal.

have also written a longer version, which contains the
data, and a cepy of this
report will be submitted with all the definitive data of the
project. Most of the infomatim is now in my hands except for
four additional summaries of clinical data which Dr. Keskiner
has prunised to send me shortly. As soon as this information
is received, I will submit a full documentation of this initial
study program.
We

more conventional psychophazmcological

‘

draft copy is still undergoing review and I
for your cements. As soon as a definitive
draft is available, this will be sent to you for your distribution.

The enclosed
would be grateful

It was

kind of Dr. Joy to send me the letter from England,
available to him copies of the definitive draft
for your English colleagues.
and

I will
Dr.

make

Simonhastakenanactivepartinthe smdypmgmm

in New York and we are ready to develop the fluphenazine decanoate
study in the Mental Hygiene Clinic. Can you tell me when supplies
will be available?

Hybestregazdstoywandymrclmdngwife.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>March 15 , 1967

Dr. Edmund

De

Maar

Associate Director
Departxent of Clinical Pharmacology
Geigy Research

Ardsley,

New

York 10502

DearDr.DeMaar:

I have read the basic data sheet on GPA 1657 with a great
deal of interest. However, some of the information is lacking
which would be helpful in dismssicns with my associates regarding
a proposed study.

Itmuldbehelpfultohaveasmmarycfthe initialhuman
data with Specific reference to dose, secondary effects, and
analgesic activity which may be available in the initial patients
receiving this drug for post-operative pain.
'

You

refer to findings from Lexington that

GPA

1657

acts

both as an agonist and an antagonist in different dosage ranges.
It would be most helpful if sane of the evidence in human subjects
for these statements were made available.

Finally, is there any direct evidence of central nervous

effects, as in EEG data?
If this information is not available in written form, I
would be pleased to arrange to meet with you to discuss what
little information may be in hand.
system

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc: Dr. T. P. 8. Watts

�</text>
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                    <text>March 15 , 1967

Dr. Ali Keskiner

Missouri Institute of Psydﬁatry
suoo Arsenal Street
St. Louis, Missouri 63139
Dear Ali,

It was

visit with us this weekend,
andIhOpethatymenjoyedwrmrkingtogetherasmchasI
a pleasure to have

did.

you

'

KathymtypedyompaperwithinafewmsamJovmand
it and it has been corrected once again. Enclosed
isadraftcopyformviewbyymmselfandﬁnen. Aswemadthe
article, we found that it followed too closely wr usual drug
reports and we felt that much of the information regarding psychopathology and laboratory tests detracted from the clinical mission.
Wespentafewhoursandediteditagain. Thesecondversion
isenclosedandthisoneseansmchmdirectand seemstous
verygoodfortheJAMA. Mldywand'l‘mnpleasedmeckboth
I have reviewed

versions and

make such

corrections as

you suggest?

In addition, Jovan and I ask whether sane additional follow-

updatabeyondsixuonthsmightmtbeinsertedmthebottmof

page five as regards the patients discharged frm the hospital
and maintained in the ccummity. This would follow logically the
last sentence on the page.

couplets our records, I wmld appreciate case summaries
for the patients added in the final report - those of Italiano,
'Iudcer,WalshandC_aldwell. AssomasIhavetl'eseandadraft
To

ofthempor't, Ibelievemcanclosetherecordinthisfirst
study program of fluphenazine.
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

,

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                    <text>Mach

15',

r967

anew);

04. James E. MeCMmaeh,
The New you: Academy 05 Medicine
2 EM: 1034:! Sheet
New you, New Yank 10029
Dean.

94. Mew/mach:

gm:
in mThank
e Aploa

am

mung much 5%: yzuCZdund
2
may.

WM.

meeting a
meeting and to

to
£3:an
a
0mm!penguin/ta
attendeng'

Wendy

Max

yowu ,

Fink, M.D.

Pangaea-06 Paychiwtay

Mth

-

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                    <text>Mamh 15 , 1967

Dr. Vincent A. Joy

Director, Clinical Research
Squibb International
uao Park Avenue
York. New York 10022

New

Dear Dr. Joy:

for the kind note from Dr. Daniel. Unfortunately,
forthe
Iwillnotbegoingtolondmattheezﬂofthismnth,
will be made by Dr. Heedman.
presentation
Thank you

have canpleted the penultimate draft of the report on
fluphenazine decarmte. The final draft should be available
We

withintmweeksandeillbepleasedtosendymcopies,
both for your own information and for Dr. Daniel - for it is
this information

to discuss.
IfIaminemrandDr. Danielwislnstodiscussanother
matter, I will be pleased to hear from him.
which he may very much wish

szbuldmoeiveacopybytheendofﬂarch.

for your interest.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfﬂq)

Thankym

�</text>
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                    <text>Hard) 15 , 1967

Professor Max Hamilton

Department

of Psychiatry

The University
15 Hyde

Leeds

2,

of Leeds

Terrace,

England

DearMax,

It was a most pleasant surprise to receive your Jdnd letter
ofMarchS. Itisanhonor'tosendyoutheenclosedoopyofow
lSDmpor-t. Ofmnmiypaperstlutmyassociatesandlhave
written during the past decade, this has excited the most interest
and it is smprising, forwewrote it inresponse to thepopular
interestayemagohopingtoimpedethsgrowinghysteria. We

havebeenunsuooessfularndISDisaspopularinNewYorkaspout

sluetsatamcetredc.

.

Myfanilymdlammostpleasedtobebeokinﬂubigcity
will

it

another year to re—establish my
probably t
Optimistic that I will be able to continue the
study programs which were so successful in Missouri.

and while

laboratory, I

-

am

WrenyouplmtoconetoNewYork, Ihopeyouwillhavean
visit me. Surely, one of the main benefits of
being in New York is the focus it represents for intemational
travelers.

opportmity to
My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

14sz

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                    <text>March 1'4 , 1987

550

First

of Neurolog
tAvenue

NW York, New York

Dear Helen,

It was

visit with you and to meet
Enclosed
trainees.
your
are application forms for
appointment in the Department of Psychiatry. I would be
grateful if they would complete them and I will then be able
to obtain a suggestion regarding their salary.
a great pleasure to

Thank you very ouch for your help and
you see fit.

the training program as
My

please continue

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>March

1’4

, 1967

Dr. Martin Kantor

15'4
New

Fast 7lst Street

York,

New

York

Dear Dr. Kantor:

AsIdiscussedwithyoueomenmths ego, theDepartment
isemmmdﬁgammberofﬂnstudypmgxamsmﬂwewouldbe’
pleasedtoomsideryom‘appoin‘bmnt. Mover, I anoonoemed
withywrrequest fora "parttimeposition at 10 20 hours
permek."
At the present time, we are not making appointments for
staff with oomxitments less than 25 hours per week, giving
priority to attending psychiatrists willing to devote 30 to
—-

MD

We per week.

.

If the possibility of a more extensive ommitment to the
is of interest to you, I would be pleased

Department's program

to have

you

call Dr.

Gerald Tarmnbam

at

369-6300 Ext. 75H.

Dr. Taxmenbaum is in ohmge of one of the special projects
in brief hospitalization with visiting nurse after-care. This

progremisanexoitingreseamhstudyarﬁlthinkyouwillfind
participation most interesting.
I look forward to a fayomble menstruation from Dr.
Sincerely yours .
'Max Fink, M.D.

Professor of Psychiatry

MF:kp

cc: 1'». Tannenbmm

Tormenbaun.

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                    <text>March 1“ , 1967

Dr. Amelia B. Donesa
u023 Spanish Trail

Fort

Wayne,

Indiana

l:6805

Dear Dr. Donesa:

I have read your advertisement in the latest issue of
regarding an opportunity as internist in a

RikeJL-SULVLM.

hospital position.

The Department of Psychiatry has
number of study programs as part of

recently embarked on
the development of a
Camunity Mental Health Center. Among the foci of study are
the problems of narcotic addicts. These patients suffer from
a wide variety of severe medical illnesses and it has become
our intention to develop a medical section devoted to their
a

care and study.

If such an opportunity with participation in an active
teaching program is of interest to you, I would be pleased
to receive a copy of your currimlmn vitae.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 14 , 1967
Dr. Robert E. Smith

12 Holywell Street
Oxford, England

Dear Dr. Smith:

I have read your advertisement in the latest issue of
The

Rita—Sauce.

Deparment of Psychiatry of the

New

York

Medical College has been actively involved in developing
Canmmity Mental Health Center in New York City under thea

'

direction of the
Freedman.

Chairman of the Departnent, Dr. Alfred M.
The development of the Community Mental Health

Center is one of the principal activities of the Department,
and encanpasses such programs as partial hospitalization,

brief hosPitalization with visiting nurse aftercare , a narcotic
addiction treatment evaluation center, walk-in clinics
as well
as the more conventional treatment units. A new lS-story
facility is under construction and is scheduled for completion
in July 1959.
The Department has 44 resident physicians in
training
and has a variety of specialized basic research

this year

divisions which canplement the clinical programs.
Recruitment has recently increased to provide for the
staffing of this new vacility, and if participation in this
program is of interest to you, I would be pleased to review
.

your curriculum vitae.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March 10 , 1967
The Equitable Life Assurance
1285
New

of the United States
Avenue of the Americas

York,

New

society

York

Gentlemen:

I

have received policy No. 00321, certificate No. 00816,
December 18, 1966, under the New York Medical
College - Flower and Fifth Avenue Hospitals group.

effective date

The policy for supplementary coverage of life insmence
states that coverage for $3,000 has been omtraoted. The
requested coverage is for $30,000 and it is my understanding

that deductions have been made

this basis.
Pleaseamendthis conu‘actforthefull ooverageasof
on

Deoenber 18, 1966.

,

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

cc:

Mr. Halpern

�</text>
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                    <text>March 10 , 1967
Dr. Jonathan 0. Cole, Chief, PRB
Barlow Building
SHSH Wisconsin Avenue
Room lOCOl

Chevy

Class, Maryland

Dear Jon,

It was indeed a pleasure to read the first report of the
collaborative depression study. That it confirmed our
observations of the antidepressant qualities of dﬂorpromazine
was most rewarding, for you surely recall the problem we faced
when we first proposed the study. I am most confident that the
definitive study will once again danonstrate the efficacy of
chlorprunazine.

That the combination was no better than chlorprmazine
I wrote Allen, our emphasis on
the combination may have historical mots and I am pleased

alone was surprising, but as

that the

your

new

study elaborated these facts.

Ilockforwardtothesucceedingrpports, andhopethat
staff will continue to share these "progress reports" of

the studies supported by the Clinical Oonmittee.
Sincerely yours ,

Fink,
m
Professor of Psychiatry
MOD.

MF:kp

�</text>
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                    <text>March 9, 1967

Dr. Allen Raskin
Research Psychologist
Psychoplmmacology Research Branch
National Institute of Mental Health
Bethesda, Maryland 2001::
Dear Allen,

Iwasverypatefulfortheopportunitytcreadthefirst

paw,

and would
report of the collaborative depression study
and
most interesting
like to congratulate you on your clear
presentation. It was especially rewarding to find that the
clinical efficacy of chlcrprcnezim in depressive disorders was
confirmed, for I can clearly recall the difficulties and
anxieties with the first Hillside study which appeared to be

oontmrytotheprevailingopinions- mtonlyregardingthe

treatment of depressith inrespmse toamyththat
chlcrpmnazine could induce depressions (1958-59).
Your study

indicates that the canbination of dﬂorpmnazine

and procyclidim was no more effective in the treatnmt of
depression than chlorpmnazine alone and the detailed measures

stew that procyclidine was exerting some pharmacological effects.
Perhaps we were still under the influence of the state of the
art for we tried chlorpmnazine alone in only a few patients,
'

fearing that the side effects wmld be too great; and then,
the patients tolerated the combination, we were

when we found

sopleasedthatwemdertookthecanpamtive studyofthe

combination against ﬂuipramine.

the merits of the culmination were, in part,
a response to the often asked question as to whether the
efficacy of the coubination in depression may have been due to
Our focus on

thepmcyclidinealmeaxri, inpart, tothefavorablereports
in the literature which appeared to be consistent with
out observations. We did treat five patients with procyclidine
alone, and discontinued the study for reasons that are unclear
to me today.

we found

�1‘”

Dr. Rankin

~2-

March

9,

1967

Aslreadycnmmportlmadeafewmtesaxﬂlslmotl'nse

withyouas commute, wtoritioism.

‘

_

MonumtonpageQIogaxdingtl‘nlmincidea-xceofeompymidal reactions with chlorprunazine alone is puzzling. Is
it possible that the patients did not get their medication as

prescribed, or that antiparkinson medication was made available
outside the regular record keeping procedures? 0n occasims,
both at hillside and in Miami, such puzzling observations were

fumdtobemlatedtoextm—medicalpmcedmsmdtheclinioel

factsmmmtsodiscmpentwithourclinioolexperionceasthis
observation would
imply.

Table 3 has most interestim date. The combinatim appears
to enhmoe or sustain excitement - an observation consistent
with the defined BEG effects of parocyclidine‘; and to enhame
drymssofthemrthandblumimofvisim-possiblemleted
to the antiornlinergic properties of pmcyolidine. that
interesting, Wet, is the clear denmstmtion that adaptetim
to the secmdary
effects of drowsiness, nasal congestion, blm'red
visimamilossofappetitedoesocctm-ﬂmscmfimingmm
clinical
It is here that the similarities of the
combination to the chlor-prunazine slam are so convincing.

swim.

Inthediswssimwogelmtheopeningpamgmphenlarges
foamsesmtmincidehoeofseoondaxyeffects. Theimidenoe

ontrnattritionmtecflﬂforthsactive mumts,m1d

mpwmdismttoohigxincowarismtoclinioelexperimoe,

mmmoontmststmldbemdemtwithnotmetmnt
or with placebo moment but with other
accepted ‘matmnts

fordepressivedisorderasﬁcrammipzmim. Amtheseside
effectsandtheattritionmtedisoomdmtwith that whichwas

observedinﬁxsimipzmimstudy? ‘misaqmasismsyperhaps
bemdifiedbyymmsubsequent emerienoe.

Mfiming'thetcwdosagermgemsyhavebemtoohigh
ismtuwwected,forwehadbeenworkingwithapowlationof
ﬁnrapyfailmsandhadedjmtedqmdomtobeabovethat
neededbyﬁOtoftlntestgrow. Sincethen,Ihavefoundthat
chlotpmmine dosages of 500 - 800 m are generally adequate.

Assimletmethankymfortlwoppommitytomedthis

ropes-mendfortmmtlutyoumyedomwrlsssstudyat
Hillsideinmfiningmmobsmations. 11001ch with
Mantidpetimtoﬁumtmpmsofﬂndepmssionsumy.
Many themes and my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc: Dr. Jonathan 0. Cole

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                    <text>March 9, 1967
Dr. Donald

M.

Shapiro

Washington University
Canputer Center
Linden and Skinker Blvds.

St. Louis, Missouri

63130

DearDon,
A‘question has been raised regarding space needs for

a computer facility. It is a possibility that in the 102nd
Street building for some space to be rented, which could
house the EEG computer unit and your projected units next
to each other, or yom‘ units alme, leaving the EEG on the
eighth floor. Would you please project in a rough drawing
the approximate space you would like to have in 18 months
for your use, either with or without wing the 1620 to this
Ifyyou will send that to me,

I will

make

this

moamuenda—

that the Departnent of
it
Psychiatry will negotiate for the space but turn it over to
tion to

you

Mr. Schwartz,

for

may be

later.

April

1

is fine.

My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MF:kp

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                    <text>.-

.~.\.'-...W—y-z

1-,...

W.

.rww-ﬁ

,..-y~..m~.-yy

—..,vn,vs‘:vx

u
’

vww-wsmw‘vca‘“

n-n

"“4."-

March 6, 1967
Dr. J. J. Wbodward
Manager, Research Computer Center
The Upjohn
y
Kalamazoo, Midhigan #9001

‘

Dear Mr. Wbodward:
I.am disappointed in not being able to attend the DIA
Computer Workshdp. I hepe that you and IBM will make such

a discussion available again in the near future.

I have been interested in various applications
of digital ccmputersto psychopharmacology. A.principal focus
has been in the analysis of EEG signals. But, in establishing
the computer facility at the Missouri Institute of Psychiatry,
I encouraged my associates to develop a model information
retrieval system. we were able to code more than 1,000 documents
from my files and these provided the basis for an interesting
demonstration both in Missouri, and at the world Congress of
Psychiatry in Madrid. Both the limitations and advantages of
this system became obvious, but since it required additional
funding, I have not pursued this further at present.
I am taking the liberty of enclosing a description of
our system. I hepe that it will be possible for us to meet
at the Association meetings, and perhaps at the next DIA
Since 1962

WbrkshoP.

-

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>March 3, 1967
Dr. Myron

-

M.

Teitelbamn

Captain, Medical Corps
M425 East Chapel Drive
’OOILmtbia, South Carolina 29205
'

Dear Dr. Teitelbamn:
Your

reply.

letter of

February 23 has been referred

to

me

for

The Departmnt of Psyclﬁatry, New York Medical College ,
has embarked on a variety of new programs based on the development of a Commmity Mental Health Center. Program relate to
the care of in—patients and out~patients in direct conjunction
with community agencies; studies in the treatnent of mrootio
addiction; and experimental studies based on the use of new
psychoactive agents. As a teaching facility, staff members
participate actively in the teaching of nedioal students and
-

resident psychiatrists.

I will

be available

after the

meetings and will be
pleasedto'arrange avisitduringthethirdorfwrthweek

of

May.

Please

APA

call my secretary at

212 369-7900

Ext. 208.

Sincerely yours ,
Pink, M.D:~'i
Professor of Psyclﬁatry

Max

MF:kp

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                    <text>March

a,

1967

.

'1». Mann. 1:11
Nissan-i Institute of Psychiatry
51400

Arsenal Street

St. Louis, Missouri

63139

Dear'mmn,
me. Dorothy and {hard Krieger am well knom, sophisticated
researchers in the field of neuro—erdoelmxology at Mt. Sinai
hospital. As old friends, they twited me to visit their laboratory.
They are particularly interested in the diurnal changes in
steroid production and rave noted that this is responsive to
dnlinergic drugs. when they described the use of atropine in
some volunteers, they complained that their Concentrations were
too low and that the effects. observed were unsatisfactory. I
told them of your development of concentrated atropine and they
would. be most grateful for a trial supply. I looked through my
file and did not bring any with me.
.

V3211;

s;

.

H,

L,

.

Vim-Iv.

Would it be possible to bring two vials of the high concentrated
atropine on your next visit to Nae York?
Incidentally, they are particularly interested in studying
psychiatric patients both with ami ‘withwt drugs and I took the
liberty of telling them of your study program in Istanbul and
Missouri. If their present trials are as successful as they
anticipate, I will enmege than to collaborate with you in the
.

at,”

"aw

m
.

v

.‘r‘&gt;i4‘7m.

IRP problem

,.

I look forward to seeing

you

on'Mday.

My

best regards.

Sincerely yours .
'

Max

Finn-1w.

Professor of Psychiatry

MF:kp

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                    <text>March 1, 1967

Dr. Manfred Bram
3‘45 West 58th Street, Apt. 5T
New York, New Yur'k 10019
Dear Dr. Bram:
Your letter
by Dr. Freedman.

of February 8, has been referred to

I

would be pleased

call my secretary at

369—7900

Ext.

2H8.

Sincerely yours ,
Firm, M.D.
Professor- of Psychiatry

Max

me

to see you. Please
’

�</text>
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                    <text>February 28 , 1967
Dr. Ray D. Waldman

USAF

Hospital

Chanute AFB,

DearDr.

Waldman:

Your

‘

Illinois

letter of

February 15 has been referred to me for
Departnent of Psychiatry, New York Medical College,
has embarked on a nunber of new programs based on the
development of the first Ccumnﬁty Mental Health Center. There
programs relating the care of impatients and out-patientsarein
conjunction with conmmity agencies which call for additional

reply.

staff.

'I'he

There

are, therefore, openings in a variety of programs
helpful if you could plan a visit to
so that I and some of my associates may have an
Opportunity to meet with you so that we can discuss these

it
this Center

and

would be indeed

programs.

IfyouamplanningtobeinNeWYorkihthenext few
call my secretary at 212 369-7900 Ext. 2&amp;8 collect.

weeks, please

Sincerely yours,
"

Pink, m3.
Professor of Psychiatry

Max

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                    <text>February 27 , 1967
Dr. Karl Rickels
University of Pennsylvania
School of Medicine
Department of Psychiatry

University Hospital
Philadelphia, Pennsylvania 1910”
Dear Karl,

very pleased that our project has passed another hurdle.
During the past two weeks I have read and re-read your proposed
protocol and would like to share with you some questions and am
enclosing a preliminary budget for your consideration.

I

am

If I understand the proposal, it is to compare two drugs,
alone and canbined with a placebo. Ratings will be done prior
to drug administration, and after two and four weeks of treat—
ment. This is not to be a crossover study and so the number
of patients required will be at least 120. This indicates that
the patient flow in your clinic is indeed large.
From the EEG point of view, the number of subjects and the
sampling will be adequate. In these patients , one consideration
might be that an' initial record taken during the pre-treatment
period should be discarded. In naive subjects, an EEG recording
is often accompanied by considerable anxiety and this is best
alleviated by a recording and the overt demonstration that

it

is without risk.

if we plan

four recordings for each subject, the
500 useful records. From past
should anticipate approximately
we
with
experience
drop-cuts,
one—third more records than we need - for a total of 650 records.
I would like to know
If this is a realistic figure, thenadmissions
what
to the study are,
new
the
patient
approximately
number of
the
weekly
appraise
we
can realistically
so that
records required. The sample length will be determined, in part,
by the number of records to be run. Other things being equal,
I would suggest at least twelve minutes of recording with eyes
closed, and two minutes of eyes opened. The termination of each
recording might be a hyperventilation, with a two minute posteach instance , therecording Will
ation cord.
a east a to 10
ute settling period followed by
a 15 minute actual recording.
Thus,

on

study will have a minimum of

Wen?

�February 27 , 1967
Dr. Karl Rickels
University of Pennsylvania
School of Medicine
Department of Psychiatry

University Hospital
Philadelphia, Pennsylvania 1910”
Dear Karl,

very pleased that our project has passed another hurdle.
During the past two weeks I have read and re-read your proposed
protocol and would like to share with you some questions and am
enclosing a preliminary budget for your consideration.

I

am

If I understand the proposal, it is to compare two drugs,
alone and canbined with a placebo. Ratings will be done prior
to drug administration, and after two and four weeks of treat—
ment. This is not to be a crossover study and so the number
of patients required will be at least 120. This indicates that
the patient flow in your clinic is indeed large.
From the EEG point of view, the number of subjects and the
sampling will be adequate. In these patients , one consideration
might be that an' initial record taken during the pre-treatment
period should be discarded. In naive subjects, an EEG recording
is often accompanied by considerable anxiety and this is best
alleviated by a recording and the overt demonstration that

it

is without risk.

if we plan

four recordings for each subject, the
500 useful records. From past
should anticipate approximately
we
with
experience
drop-cuts,
one—third more records than we need - for a total of 650 records.
I would like to know
If this is a realistic figure, thenadmissions
what
to the study are,
new
the
patient
approximately
number of
the
weekly
appraise
we
can realistically
so that
records required. The sample length will be determined, in part,
by the number of records to be run. Other things being equal,
I would suggest at least twelve minutes of recording with eyes
closed, and two minutes of eyes opened. The termination of each
recording might be a hyperventilation, with a two minute posteach instance , therecording Will
ation cord.
a east a to 10
ute settling period followed by
a 15 minute actual recording.
Thus,

on

study will have a minimum of

Wen?

�</text>
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                  <elementText elementTextId="102116">
                    <text>February 27, 1967

Port Orange Press, Inc.
883 Broadway

Albany,

New

York 12201

Gentlemen:
Regarding Invoice No. #89, it would be helpful if this
invoice was reissued addressed to Missouri Institute of
Psychiatry, University of Missouri, 5WD Arsenal Street,
St. Louis, Missouri 63139, Attention: J. Holden, M.B.B.S.

This invoice will be paid from funds

of Missouri.

Thank you

at the University

for your cooperation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Mex

Mszp

�</text>
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                    <text>February 27 , 1967
Dr. Vincent Crenata

Pfizer

Chas.

8 Co.

Groton, Connecticut
Dear Vince,
'I'hank you very much

for the reprints of our thiothixene‘

paper. I have sent copies to each of the co-authors.
DuringthepastweekIhavehadachancetoreadthe
descriptive brochure of P-3693A, and the accompanying article
by Hackett and coworkers. The clinical data is impressive
and the canpound surely should be studied further as an antidepressant. We should be able to make such trials later on
this spring, and if you are interested in having additional
cases in out—patients , I would be pleased to discuss a project
with you.
My

‘

-

best regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
Mf'ﬂcp

�</text>
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                    <text>February 27, 1967

m. dimes Cattell
880

New

Fifth

York,

Avenue
New York

Dear Jim,

TheNassauNPSocietyMshmoredneagainbyaskingtlut

I participate in tha report in the District Branch Newsletter.
Please includemonyommailing list andeilldowhatIcan
to support this venture.
My

best regards.
Sincerely yours ,

”-9.:

Fink, M.D.
Professor of Psychiatry

Max

Viv—.3

r,
r.
0—;

"-(~,‘-

‘
41-“

,Izur-u

.
w.

u":-

:Wm-

tawny"

urn-n.

’L’J‘

Wyn—.m-

.

m

£Wl’mrl*ww:lsﬁfﬁww~

~‘Wm‘ms‘mmwvw

M;

34sz

�</text>
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                    <text>February 27 , 1957
Dr. Alain Sanseigne
The Squibb Institute
Georges Road
New

Brunswick,

New

for Medical Research

Jersey

Dear Alain,
me to participate in the
It was kind of you to invite
must
discussion of fluphenazine. I
tell you that I enjoyed

the afternoon very much, and I hope that the contribution
was helpful to you and your associates. I am impressed with
the data of fluphenazine decanoate, and am anxious that this
program continue. Surely, a liberalization of the dosage
ranges will make fluphenazine me acceptable to hospital
psyclﬁaatrists.
'

I also have had an opportunity to read the surmary of
data on 8010,1496. This is indeed an interesting canpound
and Dr. Horovitz is to be congratulated on the description
he provided. If there is an opportunity to study this
compound later this spring, I believe we would be interested
in doing so.

I tell you how much I enjoyed our dinner Friday
evening? Your wife and yourself were outstanding hosts and
provided an evening that Turan and I will long remember.
Need

My

best personal regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

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                    <text>February 27, 1967
Dr. Ali Keskiner

Missouri Institute of Psychiatry
5u00 Arsenal Street
St. Louis, Missouri 63139
Dear Ali,

I was sorry that you did not join Tumn on his visit this
weekend. We did have an interesting visit and I hope that you
will come to New York quite soon.
Enclosed are xerox copies of all the case reports on
fluphenazine deoanoate patients which were sent to me in

late

December.

Give

my

I hope these are helpful.

best to

all

our friends.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Mex

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                    <text>February 2% 1967
Dr. Alan Miller, Cmmissioner
Department of Mental Hygiene
Albany, New York
Dear Alan,

I have recently completed the enclosed report expanding
on the data presented at the Madrid Computer Cmfwenoe.

Recalling your interest in that mating, I am taking this
opportunity to send you a cow. Perhaps, we can continue
the discussion begun at that time.
My

best regards}
Sincerely yours ,
Max

PM,

M.D.

Professor of Psychiatry

MFﬂcp

�</text>
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                    <text>.

my,”

February 24 , 1967

Dr. Louis Kam’nsky
IBM

1'r’mr‘wzvg.'%vvaﬂmmgnun/Aw:

Corporation

Yorktown Heights , New York

Dear Dr. Kominsky:

I had the pleasure of hearing Dr. Gelernter describe
of his workmile at IBM at a recent ACM meeting. In
the course of the discussion he referred to the pattern
recognition programs deve10ped by yourself. As I am
interested in the pattern recognition problem, I asked
some questions and he suggested that I write directly to
you for the references to your work.

rm,

A

M

some

‘1‘:

'5
,

If reprints of your recent reports oﬁ the pattern
recogxition of the PAP smear are available , I would
appreciate a copy. If not , may I have the citation?
Thank you.

Sincerely yours ,
Ale-'2

Quarry-1"”.

Fink, M.D.
Professor of Psychiatry

Max

.
3“}

Wemﬁfi'IW‘i'ﬁw‘;

,

.

e

"‘43?

_

MF:kp

�</text>
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                    <text>February

21%,

1967

TIAA

Prenium Department
730

m

New

Third Avenue
York,

New

York 10017

-

”71"J“MY‘.'

“4""-

TW.9‘W'('M7R’V'u‘n-’l‘a""

Gentlemen

:

writing with regard to annuities A-195755—2 and
P—llu77l-H. Initially, the premiwns were paid by the Psychiatric
Research Foundation of Missouri, later by the University of
Missouri and since the summer of 1966, from the New York Medical

I

am

College.

fir-“”1””

A

"may:

1

During the past two weeks , I have been able to check with
the College regarding the deductions to have been paid to TIAA—
CREF on my behalf. There have been considerable discrepancies
between the amounts requested to be paid, and the amount deducted
from my paycheck. It would be most helpful, therefore, if a
record of all the payments to TIAA during 1966 could be made
available to me at the present time. I hesitate to write requesting such a sunmary, but the records at the College appear
to be in conflict and perhaps the easy resolution would be to
obtain an actual record of each of the payments made on my behalf.

'
Vinyl-Is"

:7

my address of record to my
Arleigh Road, Great Neck, New York 11021.

Incidentally, please change

permanent new hone

at

39

Vmﬂ‘ﬂp‘i’x‘!

Thank you very

web for your help.
Sincerely yours ,

Z‘WP’W’X’

nan-,1

arm.

Fink, M.D.
Professor of Psychiatry

Max

Mazwgr'rrwmwmsrw

age-N»?

0

yw'l‘w’

‘-@795117"w219\325ﬁ%m%‘miﬁ’:ﬂLa.»

w
L'

W's.

Mszp

.

�</text>
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                    <text>February 2a, 1967
Dr. Jenathan 0. 0019, Chief,

BarLow
SMSH

PRB

Building

Wisconsin Avenue

Fkxxn 10C01

Chevy Chase, Maryland

RE: MH~13358~01
anathan:
I am.writing once again with regard to the project
"Quantitative EEG Studies in Psychopharnecology.“ The initial
recruiting has gone well, and I have been able to use the funds
of MH~13003 in the interim, not having received an actual award
of this grant. IBM has indicated that they will be able to
deliver the 1800 earlier than I anticipated in the application,
with the delivery date now set for the first week in May.

Dear

Insofar as we have not had an award to date, and there
has been some delay in the expenditures, I am writing, with

the perndssion of the appropriate college authorities, that
the initial year of this project be started on April 1, 1967,
rather than the requested January 1 date. If this is possible,
the expenditures, bookkeeping, etc., will be facilitated.
Thank you

for your cooperation.
Sincerely yours,
Max

Fink,

M.D.

.Pttﬁessor of Psychiatry
,

‘MF:kp

Endorsement: This request
is approved.

MHEl3358-Ol

to delay the starting date of grant
FT Haydn

Morgan

Grant Administrator

�</text>
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                    <text>February 28 , 1967
DP. To Po'So

watts

Ardsley,

York 10502

.

Geigy Phannaceuticals

-

New

Dear Paddy ,

It was a pleasme having lunch with you today. As we
discussed,” enclosed is a revised S'I‘-155 protocol. Would you
please send me .your anxiety scale and any other suggested
forms for Use in this study. As soon as I have reviewed
these scales I will send you copies, as we plan to use them.
(May
I remind you to send me the Sugeman and your own ST-lSS
data?

1

,

May

I remind you again to arrange to send me capsules
50 or 25 mg each for our narcotic

of Tofranil, either

antagonism study. A proposed protocol is enclosed. This
has not yet been approved. It my require some modificaswuld be sufficient for your records.
tion, but

-

it

also pleased to confirm our interest in kets~imipramine
both for its nemophysiologic profile and for its
clinical antidepressant activity in corparison to Tofranil.

I

am

(GP 35259)
My

best regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>Pebmary 23, 1987
Dr. w. P. Colvin
Medical Department
Burroughs Wellcane and Co. , Inc.
1 Scarsdele Road
Tmzkahoe, New York 10707

Dear Dr. Colvin:

interested in your consents regarding the
antidepressant effects of procyclidine. At the time that
I undertook systematic studies of imipramine and chlorprunazine
at Hillside Hospital, we did treat a small number of patients
with procyclidine alone, in order to determine the effects on

I

was most

psychological

tests,

EEG

and behavior.

We

did not have

sufficient material for a detemination of changes in psychological
A copy of that preliminary
tasks, but the EEG data was
report is enclosed for your interest.

I look forward
convenience.

mind.

to discussing this with

you

at your

Sincerely yours ,
MEX

PM,

MID.

Professor of Psychiatry

Mszp

�</text>
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                    <text>February 23 , 1967
Dr. Sidney Malitz

New

York

New

York,

State Psychiatric Institute
Street

722 West 168th
New

York

Dear Sid,

I have recently returned to New York and
like to re-establish my association with some of the
scientific societies in the City. I would like to reapply
for reinstatement as a member of the New York Society for
Clinical Psychiatry. When I met Arthur Zitrin yesterday,
he suggested that I write to you.

I

As you know,

would

Would you

be necessary.
My

kindly send

me

such application forms as may

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 23, 1967
Dr. Souren Avakian
The Denver Chemical Manufacturing Company
35 Camerce Road
Stamford, Connecticut
Dear Dr. Avakian:
Thank you very much for your kind invitation to join the
membership of the Carl Neuberg Society. The invitation came

as a surprise as I have not participated in this sociew in
the past. The content of the forthcoming progran of "Drugs
and Dreams" is indeed of interest.

waver, before undertaking to accept your kind invitation,
itmuldbemosthelpﬁzlifacopyofthepresentnmnbership

list could be made
Again,

my

available.

thanks for your kind invitation.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MP:kp

'

�</text>
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                    <text>February 23, 1967
Dr. Robert C. Batterman
Clinical Pharmacology Research.Institute
2030 Haste Street

Berkeley, California 9u70u
Dear Bob,

It

was

a pleasure meeting with

you again

in Lexington

I very much enjoyed discussing your study program. As
that I will be in California in the near
is
it unlikely
am
this opportunity to request cepies of
I
taking
future,
center which may be related to psycho~
frcnxyour
any reports

and

active or anti~anxiety agents.

Incidentally, your description of a two-point pask as

an index of drug
My

effect,

was a most

interesting suggestion.

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

max
MF:kp

�</text>
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                    <text>February 21, 1967
Dr. Richard Abrams
10“ Childress

Sheppard AFB, Texas 76311

Dear Dr. Abram:

abstract should interest you. I have not
article, but think that it is important that

The enclosed

yet seen the
you do so.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkp

�</text>
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                    <text>February 21 , 1967
Dr. Peter Raper

Allan Memorial Institute of Psychiatry
McGill University
Montreal, Quebec
Canada

Dear Dr. Roper:

I would be pleased to have a reprint of your article
"Drug Addiction, Psychotic Illness and Brain Self—Stimulation,"
which appeared in the Canadian Medécd Abdomen Jon/malt in
November 1966. Thank you.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 21 , 1967
Dr.

Man M. Itil

Missouri Institute of Psychiatry
SMDO Arsenal Street
St. Louis, Missouri 63139
Dear Turan,
Here

is hilf the

supply of "Clinical

Trial of

Navane

(Thiothixene) in Schizophrenia." Would you please give some
to Dr. Ponce and Ali. I have kept some for Jovan here for
answering

reprint requests.

Sincerely yours ,
Max

Firﬂc, M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>February 21, 1967
Dr. William Guy

ECDEU

Coordinator for Data Analysis

The George Washington University

Bicmetric laboratory

Roan 601

11% Nineteenth Street, N.w.
Washington, D.C. 20036
Dear Dr. Guy:
Enclosed are the RPR forms that you requested. Incidentally,
there is a lack of clarity in item 5b, since the phase of the
investigation is unclear to me. I trust these are helpful.
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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Dr. John Donnelly

Psychiatrist-in—vChief

Institute of Living
200

Retreat Avenue

Hartford, Connecticut
Dear Dr. Donnelly:
LSD

It was nice

of your staff to abstract our study of

in the Digest.

'meydidaver-ynice jobinthesmmary.
I would be grateful if you would change my address of
record from St. Louis to the Department of Psychiau'y,
New York Medical College, 5 East 102nd
Street, New York,
New York 10029.
Sinoemly yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>February 21 , 1967
Dr.

Julian J.

Leaky

Executive Secretary
Mental Health B Study Section
Division of Research Grants
National Institutes of Health
Bethesda, Maryland 2001“
Dear Dr. Lasky:

RE:
.

MH

13619-01

If possible, it would be very helpful to me if the
site visit could be arranged for April 10 , as this

Blaohly

will coincide very well with another trip

If this is

satisfactory.

West.

.

not possible, the other dates will be
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>February 20 , 1967
Box Y2122

New York Times
1&amp;5? Broadway
New York, New York

Dear Sir:

of Psychiatry is undertaking a series of
evaantion programs and is developing a laboratory in computer
applications. A specific application is in the analysis of
EEG, and also in the use of rating scales in psycroprannaoology.
The Department

I read

your advertisement with

interest and I

pleased to review your curriculum vitae.

would be

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mf‘ﬂcp

�</text>
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                    <text>February 13, 1957
Dr. Warren A.

Mean

Associate Cluinnan

Hissomi Institute of Psychiatry
5&amp;00 Arsenal Street
St. Louis, Missouri 63139

Deaern,
Since writing to you on January 23, I have heard nothing
of the resolution of the two questions which you posed earlier
inthemonth. Nultoasawmﬂutﬂminpedimenttopaymnt
oftheinvoioe for services inNovanberhasnowbemrmed?

Sincerely yours,
Fink. M.D.
Profesacr of Paydﬁatxy

Max

Mszp

�</text>
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              <elementText elementTextId="27618">
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                    <text>February 13 , 1967
Box XBQGH

New York Times
1&amp;57 Broadway
New York, New York

Sir,

Dear

The Depar'unent of Psychiatry

computer

is establishing a departmental

facility for scientific application especially in

analysis of neuroplyaiological signals , psychiatric rating
scales and biostatiatics. The center will begin with an IR!
1800 which is to be delivered in early May.

I read the advertisement with interest

to read

yomc resume.

and wwld be pleased

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MEN)

�</text>
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                    <text>Dr. Stan

Goddard

Shmm

PM

13 , 1967

Science Laboratory
WarInstitute

Hadley Research
Dallas, Texas

DaarDr. Shannon:
We

have mad your

descriptim of the Stat-Pack in a recent

ismoftheACNCmmicationswithmatintmst.

mmyof

trapmgrmliatedintablemintmstusdewmldbe
gratefulfwaoopyofyotmusmmanual. Wmhwehadan
ty’comadthis,1muldliketowritetoyouto

obtaintlnmicmfilmwrite—up and’atape. van-harem
dmges for such a service?

Wm

Thank you.

Sincerely yows,
Max Pixﬂc, M.D.

meesscr of Psychiatry

�</text>
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              <elementText elementTextId="27642">
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                    <text>Febmary 13 , 1967
Dr. Werner Totem
75.0 South State Street

Elgin, Illinois

60121

Dear Dr. 'IUteur:

Iantaldngthe libertyofenclosingacopyofaletter

andanabstructregardingacase inwhichlwasrecently
involved. I am sending this to you in response to a suggestim
from Mr. George E. Hall of the Marleen Medical Association.
I had mitten to than for- advice.
Mr. Hall referred to your report at a meeting of the
Merican Academy of Forensic Sciences. If a copy of that
report or any other relevant infonnation is available, I
mld appreciate reading these, as I am intrigued by the
'

problem.

Thaxﬂc

A

you

for your (reparation.
'

Sincerely yours,
Pink, Md).
Professor of Psychiatry

Max

Mqui

�</text>
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                    <text>February 13, 1967
Judge Merino
Bergen County Court
Newark, New

Jersey

Dear Judge Merino:

Last month I participated in the review of the case of
Trantino. Among the questions which you raised was
one regarding the interaction of the psychiatric drugs and
alcohol. Enclosed is but one of the recent reports which
show that the interaction between psychiatric drugs and
alcohol is high.
Thomas

You will note that this study has been done in animals,
but similar effects are likely to occur in man under the
same

conditions.

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>February 13 , 1967
Dr. Donald Shapiro
Washington University
Computer Center

Linden and Skinker Blvds.

St. Louis, Missouri 63130
Dear Don,

Dr. Slobody will not be available next week and so
made an appointment for you at 2:00
p.m. on
February 28. If that is agreeable, fine. If not, please
call Dr. Freednan's secretary or Kathy.

they have

I

had such a good

My

best regards.

visit with the

if you agree, I would
visit them together, if time pennits.
University that

people at New York
arrange for us to

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mlecp

�</text>
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                    <text>February 10, 1967
Dr.

Men M. Itil

Missouri Institute of Psychiatry
suoo Arsenal Street
St. Louis, Misswri 63139
Dear Turan,

I have just received the Psychiatric Research Foundation
Publication No. 1—67 - your sunmary of clinical and EG drug
evaluation studies. I think it is fine and congratulate on
an unusual presentation.
I think this is

satisfactory to send to the BCDEU
investigators as the report for this period. In addition,
would it be possible for you to send me about ten copies, in
the event that they may be useful in supporting the develop—
ment

of

new drug

Many

most

studies in

thanks and

my

New

York.

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Dr. Turan

M.

February 10 , 1967

Itil

Missouri Institute of Psychiatry
SuOO Arsenal Street
St. Louis, Missouri 33139
Dear ‘Iuran,
Some time
Hy Denber brought to my attention the
go,which
problem
of magnetic tapes
he had shipped to St. Louis, and which
hadnotbeenretm'mdtohim. Oncneofmyvisitslwent
the Computer Center with Connie and we found a number of tapes

which were then shipped

to Dr. Denber.

I thought we had shipped all except the few which I had
set aside ﬁrm the cyclazocine project.
During my last visit,
Iched&lt;edagainandallthosethatwecouldfindweresent
to
my office, except two tapes which I had intended
with
to
carry
me and which I requested Connie to mail.
Enclosed

is a

nanorandum from Dr. Denber

and he indicates
that #14 tapes are still missing. There are four
in my office
mmdtwovmichareenroutefruns . Louis toNewYork.
This
still leaves an accounting for 38 tapes.
Would you

personally institute

a
to the best solution to this question?

search and advise

Manythanks.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

me

as

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                    <text>Dr. Craig D. Emil
Hedical Director
Sandoz Pharmaceuticals

Hanover,

New

Jersey

Febmuary 10 , 1967

07936

Dear-Craig,
Thank you very much for the aupply of mllaril tablets and
placebo which arrived safely. I am most grateful for your cooperation.

Wewmldbegladtodismssthe'I‘PS-23 smdyinalcoholics

Wmmmdy.

Sincerely yours ,
Pink. M.D.
Professor of Psychiatry

Max

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                    <text>February 10 , 1967
Dr. Donald Shapiro
Washington University
Oanputer Center
Lindell and Skinker Blvds.

St. Louis, Missouri

63130

DearDon,

I have had a nmnber of sessions with Dr. Juluis‘Korein of
York University regarding his interests in using computers
in the recording and analysis of narrative data. He was kind
enough to take me on a visit to the School of Engineering of
New York University and I net the
director, Dr. Leo Tick. It
was a fascinating afternoon since Dr. Tick is particularly
New

interested in the analysis of time series and is now pushing
the bispectral estimation, that is, the fourier Transform of
the third mnent function of a stationary randcm process. He
hasnotdone toomuohwith it inEEG, but sounds likeanun»

usually bright,
Enclosed

if

aggressive, analyst.

is his

annual report which

may

interest you.

Secondly, as I told Man, and as I discussed with
I have decided to withdraw-1 the APA exhibit for this year.you,
With the inability to get machine time and with the
very short
time available for debugging and preparing the exhibit
I felt that we could do so much better next year, that Iitself,
oontactedIBMandtheyhave agreedthattheywouldbeas
interested in 1968, if we wish to go ahead. I think when
unitinNewYorkis Operational, it shouldbevaryeasytoour
decide if and how we should go ahead at that tine.
As I indicated on the telephone, I an most pleased
that
have
decided to join us and think that the opportunities
you

here are
My

still very good.

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max
MP:kp

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                    <text>Pam-my 10, 1957
Dr. Leo J. Tick
Data Processing and Computation Laboratory
New York University School of mgimcring
and Science

University Heights
Bronx,

New

York

Dearheo,

Onthewaylurefmmyonmlabomtorylmadyomanmal

report and

was as inpresacd with

it,

as with

my

visit with

you. Theme other laboratory michhcdthe entmsiasm which
you generated was that at Washington University and I am

Sielightedtol'ave motheoocasiontodiscusawpmblem

thyou.

I

am

optimistic that my associate from St. Louis,
joixﬁngus inﬂowYork-andwhen

Donald Shapiro, maybe

hcdoes,

Imldliketomongoforhimtovisitymr

laboratory as well. I think your suggestion of occasioml
meetings about the ma data problem, is an interesting and

imtantomandawomtributionthatloanmke,
Iwill
do
gladly.

Trunk you

for your time.
Sincerely yours,
MGR

Pm,

MID.

Professor of Psychiauy

MP:kp

�</text>
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                    <text>February 9, 1967
Mr. John Langone ,

Editor

Psychiatric Opinion

Nine Vernon Street
Framingham Centre , Massachusetts 01701

Dear Mr. Langone:

very much for your kind imitation to amplify
on our experiences with LSD. My associates and I, being
Thamc you

of the need for better documentation of the
problems of
acperinlentation, prepared the report which
you read in the Mchiveé 06 Genmﬁ PAgdLémy. It represents
the best we could extract from the available data. Unfortunately,
the study of LSD has been a side issue for us and we have not
paid as close attention to the personality aspects of all our
patients as we did in those who had canplications. For this
reason, it would be difficult to write a scientific report of
some merit since almost all the data that we have is already
painfuny

aware

LSD

published.
We

must decline, therefore, your kind

invitation, and

trust that we will have more rigorous information of interest
to you at a later date.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

1‘11“:qu

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                    <text>February

9,

1967

Mr. Alexander M. Peter-be
39 Cedarlewn Blvd.

Valley Stream,

New

York 11580

Dear Mr. Poterba:

for the copy of Wittenbom‘s book
Clinical Psychoplumacology of Anxiety." I have read
this during the past few days and found it met interesting.
The date he presents is highly sophisticated and provides
some of the more rigorous data in our field.
"The

Thank you very much

Thank you

for yew courtesy.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MFsz

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