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                    <text>June 20,.1972

William.Guy, Ph.D.

ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 ﬂuff Court
Kenoington, Haryland 20795
Dear

Bill:

I have read the various mohk~ups of scales sent on June 12.
the extant it is possible to review these outside the laboratory
situation, I have done so.

To

The
11

RPR

seems

satisfactory.

The FMS is an interesting addition. It is not clear whey item
is requested. These items may be significant only in relation to

concurrent illneoaes or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
to use.

The 90138

is

an

interesting change,

TESS, Data Shipmont, and 93E

satisfactory.
We

should have

that

seem: easy

in using these forms,

Sincerely yours.

1,1“. 5.9.
m
Profoooor of toychiatry
“3:13

‘

are difficult to asSess but seem

littlc difficulty

anticipate thoir inplouontatian.

and one

and

�</text>
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                    <text>Q,

l":

June 20, 1972

William Guy, Ph.D.
ECDEU

Coordinator

for Data Analyses

George Washington University

Biometric Laboratory
11501 Huff Court
Kensington, Aaryland 20795
Dear

Bill:

I have read the various mohk—ups of scales sent on June 12.
the extent it is possible to review these outside the laboratory
situation, I have done so.

To

The

RPR

seems

satisfactory.

My

an interesting addition. It is not clear wheytitem
II is requested. These items may be significant only in relation to
concurrent illnesses or conditions, and I do not see this information
recorded. But I see no difficulty in obtaining these data.
The

to use.

PMS

is

The DOTES

is

an

interesting change,

TESS, Data Shipment, and DSE

satisfactory.
We

should have

and one

that

seems easy

are difficult to assess but seem

little difficulty

anticipate their implementation.

in using these forms,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

and

�</text>
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                    <text>7&amp;I-884
ME?

Kr. Lawrence Erlbaum,
Vieo—Prosidont,
V. K. Winston &amp; Sons,
1511

street,

3. 1973

Inc..

N.W..
washington, D.C. 20005.
K

Dear my. Erlbaum,

Enclosed are three sets or dooumonts for tho new
volume.
#20.

Clinical Progroas in convulsive

Therapy

is report

.l

w-uv’.

1—.

-r-—Ann~w

umqu,’uw

w—uv—p—mv-z’arr

W‘wrnww

1
v'r

-.

rrrrp-v'

a

wwwuvv—wa

-.

vmmmm-w

wrmm—aq-mx.w—mmupmww

1-

my”

.‘mn'l‘rgsv

:u

Irv‘cﬂymirﬂ"!

After submittﬁig, the report by manual: and William,

in relation to the summaries written by Katy and
myself, I made some changes in this summary, sent tham
to MoGaugh and Villinmn. and have gust roceivod their
opproval for the changes. I: you will compare the draft
in your hands and this draft, you will find that the
changes are essentially in the first two pages, and
thereattor they are minor.
and

1 am also submitting a coyy of #15, the article
by Koran: on multiple BOT. I am enclosing two copies:
one as revised by the author, so that you can see where
tho small ohangiu wore made; and a rotypod copy which may
not. it easier for your editor. These changoa wore
requnotod by mo, insofar as on important report concerning
multiple EDT appeared in tho Fobrunry, 1973 issua of the
Anoricon Journal of ?sychiatry.
Only looking at this moment is an introduction by
Dr. Ritz. I visited him in Wishington yesterday, and
he agreed to send it to no boforo Friday, indicating that
the delay was in port occasioned by the necessity to check
with sons of his superiors.
Ono

answer,

the

1973

This

tachnioal problem which I did not know how to
way to refer to other articles in

is the proper

I have worked thaw as
and "this volume” in the citations.
arbitrary, and I would ask your editor to not a

noon volumo.

in the text,

is

more acouptdble

For conveniouoo.

style.

�w.

Immense Erl'bmm

this

We

are

now 99$ up

~2~

ta date.

month. or early Jung,

than!» hm

when

mdvould like

May

I

3. 1973

Except for one weak

V111 ha

in

Rumpus.

aimerely yours,

Ma: 11:31:, Md).

Executive Director
Emu.

later

tomt v1thyou, 01-er

um edited drafts at year earliest conveniences.

ear/1.3

I

�</text>
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                    <text>7583—07383
13 February 1974

n

E M O R A R D U H

To:

Stanley P. Yollco. M.D., for walton W. Shrcava, H.D..
Ph.D., Acting Aaaociata Chief of Staff for Raaoarch,
VAH~Notthpott

From:

Max

Fink. M.D., Profcaaor of Psychiatry

Subject: Proposed Studios of Alcohol Dapondance at VAB-Northport
were urged to develop studies in alcoholism
at VAR—Notthport to oupplomant the ongoing rascarch weafforts 1n
proposad
the treatment of opiate dopendenon. In Soptanbor,
a notion of studies to answer thrno questions:

Last guano:

we

tolerance dovalop to long-acting
bannediasopinoa?
Docs

Boas coloranca to a bonnodinaopino pto~
Vida "blockade" to alcohol (by cross-

tolarance)?

If such blockade occura, can it be put to
clinical use tn tha maintenance of chronic

alcohol~dapandant Iubjocta by high doses of
a lags—acting bonnodiasopine?

In this projact.

wa proposed

to no: a

new

bonzodiachinc,

is particularly promising because wc
hava obaarvou a duration of action that in conoidotably longar
than other known bonaodiaaopinaa, nonaurcd by clinical observa—
I have extions, KEG oxaninntiono, and blood level studies. Unitad
States
tonaiva axpartenca with this compound, both in tho
OR!~8063. This compound

and Turkay, whora

cally acttvc.

I

havo found

it

-1-

to ba Info to use

and

clini-

�YolleslShreeve

13 February 1975

-2~

Since submitting this proposal, on have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of
the experiment. I believe we have answered the design and safety

questions satisfactorily.

In Decenber the Committee requested that we give than an
nunber; 1 indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971. referred to studies than approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
protocols to the FDA for repeated administration of the drug in
can. These studies have not only been undertaken but have been
published, and include two reports submitted to the Committee:
"On

the Anticsxisty Properties

of'a

New

Benso~

gygg;.Thsr..Rss., 15:
288 (19?3). In this study, Sskalis and his
co~workers have given 0R3a8063 for 21 days from

diasepins,

oar—8063."

30~150 as a day.

-

"08F;8083, an Early ﬂuctuation of'a Haw Anti—
anxisty Agent.” Curr. Ther. Rust, 14:664 (1973).
In this study, Gallant and his nodworkers re—

ported the treatment of

8

chronic alcoholic

inpatients for an average of
to 160 as daily.

25 days, from 10 mg

In addition to these two published studies, I have submitted
capies of reports of my own work; and indicated that I an personally aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day. in a study which I am
aonitoriug in Istanbul. I also attended a conference (June,
1973) at which 7 investigators (including Sakalis and Gallant)
presented data on varying dosage schedules in man for extended

periods.

in requiring a letter from the FDA justi~
tying this study. is asking for a procedure which the FDA does
not ordinarily follow. In this request. I believe the Committee
is exceeding its charge. Should the Committee persist in this
denand-that we obtain prior approval for a study from the FDAr—
the centers would abrogata their responsibility to decide whether
a study should or should not be dons at the VAHrHorthport on the
data presented. Continued insistence on IND approval as a pre~
requisite for studies will not facilitate research at VAR-“orthport and will not establish that hospital as a center for human
The Committee.

studies.

�YollcsZShtnnvc

~2~

13 Pabrunty 1975

w-mw

"'Wrwwwr»

I halicvu that the Connittcc salad «ﬁnitely in its original
ruquast for 130 duct; tad that I aattd unwingly 1n attunptins to
lag: thslr dcuand. I hulicvn I! havo submittod sufficient in—
foranttan to warrant the judgnoat that the study should be approvud. ¢nd nah your udv1¢o is to the aux: stop for us.

M3/cil

3-th

�</text>
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                    <text>mm}: 16 ,

196%

Dr. Sam Gum
Department of Paydﬁauy
Washington University
School of mdicine
660 South Kingshigmay

St. Louis, Missouri
DearSam:

”Fervent
The

rest

ofanail.ashoewaslost
of.

of the past

the story
two years

is

. .

."

obvious, and I regret that the events

Wad in the present molution.

Maven I am taking this Opportunity to thank you personally,
not only foryourkind
mbehalf ofthe Missouri
Institute of Psychiatry but also became you were can of the!

mats

fewmubmofﬂnfacultywhotookmtimandtmubleto

m
when
effcmta

on

to St. Lmis. For your hospitality. and your"
behalf of tha Institute, I shall always be grateful.
35.1103me yours ,

Max

Fink,

mmctor
MF/jb

14.13.

�</text>
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                    <text>7hAP~05ﬁAP

1 February 1976

Eric: Freyhen,
2015 B

Street.

H.D.

R.W.

washinscon, 0.0. 20009
Deer Erich:

I

for the report of the nominating Cam—
mittee.
feels that he can eccenr
the
aieeion as Secretary for at least one more year.
plieh
went to thank you

I have spoken to Jon and he

I have asked

him to put the Q;

for the next council meeting.

subscription

on the agenda

the Johns Hopkins Pres: will have an exhibit
at the forthcaming meeting. I suggested
the: Jon inquire as to whether it would be possible to put copies
of §g_with a subscription for: either at their exhibit or in one
alongside. Should you think it is a good device. you may wish
to have copies (7 complementary copies) on exhibit at the meeting.

I

of the

am told that
APPA volumes

Again,

my

thenke for the nominating Committee report.

Sincerely ycure.
Mix

Mrlcie

Fink,

M.D.

�</text>
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                    <text>STATE UNIVERSITY

or

N‘r’iW

Health Sciences Center

YORK AT
-

srorw

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phone: 516444-2447

December 2, 1976

Samuel B. Guze, M.D.
Spencer T. Olin Professor and

of the Department of Psychiatry
Barnes and Renard Hospitals
Washington University
School of Medicine
Head

h9h0 Audubon Avenue

St. Louis, Missouri 63110
Dear Sam:

Enclosed are some reprints you requested. The thesis
and behavior has been tested best with antipsychotic
of
drugs. It is Still an idea with thymoleptics. The best
report is the diethazine study (1958). The clearest pre—
EEG

diction of antidepressant activity is cyclazoeine
and recently, the studies of mianserin by Itil.
My

(1969)

regards.
Sincerely yours,
Max

MF:fg

encls.

Fink,

M.D.

�</text>
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                    <text>‘\

»

December 11th, 1972
hire. 0. (Manor .‘

Personnel Officer.
Surge E.

Rm. 1&amp;9.

Dear Mrs. Gwinner;

I an in the prooesa of moving a study program from the
to the Health.8oiences Center. As

Kev York medical College

part of this program we already have received support (Antagonists
to Opiates, Knuth2e72~115). Under this oontract I have
recommended for appointment three young research aasistants:
Peter Irwin
Carolyn Poinier

Ira Snapper

of the principal ingredients in Obtaining the
nonperation of these young people in working at Stony Brook
has been the opportunity to participate in the teaching programs
of the university.
One

I have been asked by them today whether they can obtain a
temporary identification card so that they can meet the requirements to register for courses for the next semester. It is my
understanding that such an ID aunt he in hand before December lhth.

7

I have recommended thsle three young persons for appointment
to the Foundation; their papers are in process; and funds are
available. I would be grateful if you could provide any assistants
with the nsoessary temporary documents to permit than to
participate actively in the edunational and cultural activities
of the university.
I en indeed grateful for your cooPeration.

‘

Sincerely yburs,

Fink, M.D.
Professor of Psychiatry
Max

Approved:

Mllid
no. to David Pappalerdo

Stanley F. Yolles, M.D.
Chairman and Professor

�</text>
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Win-q“.

Tut”

'r'

,_‘

.

myr-pi‘.,vvr.,..«v;V.r.,‘,

K
731:0}1l

February 27. 1973
Herbert Haber
Paneth, Haber &amp; Zimmerman
150 East 58 Street
New York City 10022

Mr.

Dear Herb.
The enclosed request from the IRS for an explanation for
lete—filing of the 990, end the penalty, requires your masterful

hand.

,

Many

thanks.
Sincerely yours,

'ww'n-W

.72"

an

w-wrv

"waﬂr‘wm-min2w9wmm‘”

"

iltmzLW'mAm-w~

WF'WR“

J-n

&gt;5va2m1u

Mex

Pink.

M.D.

�</text>
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                    <text>"WWW m-“W

gun-

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January 30, 1973

~q...._,-.»-

»

Herbert Haber
Paneth, Haber &amp; Zimmerman
150 East 58 Street
New York City 10022
Mr.

Dear Herb,

Enclosed

is

e capy of the

latest letter received

from the

pleased with the
regarding the audit of the Association. I
end
and
want to thank you
your associetes for your help.
response,
At the meeting of the Board of Directors of the Association
held on January 25, 1973, they elected to request your firm to carry
out the 1972~1973 audit.

KEV

My

am

best regards.
Sincerely yours,

Max

Fink,

M.D.

.

u...

�</text>
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                    <text>October 13 ,

1981’.

Dr. Habib Nathan

University of Florida
Department of Psychiatry

Gainesville, Florida
Dear Dr. Nathan:

and I enjoyed your visit to the
week-end. I am pleased to offer you an appoint—
ment as Senior Research Scientist, at the Missouri Institute
of Psychiatry, effective on or about July 1, 1965 at an
My

associates

Institute last

In this appoinment, it
in the research pro:
will
participate
you
w
direct
under
supervision.
the
Institute
of
my
grams
While it is my understanding that you are eligible
for only one more year in the United States as an exchange stu—
dent, I would be pleased to do whatever I can to assist you to
continue your program fora longer period at this Institute,
or failing that, to assist you in obtaining a provisional appoint—-

initial salary of

$13,000 per annum.

is anticipated that

nent with one of
As

my

Canadian associates.

I explained, the Missouri Institute of Psychiatry

transition period at the present time and it is
quite probable that the appointment to the Institute will carry
with it a eoncm'rent appointment to the Department of Psychiatry
of the University of Missouri School of Medicine. At the present
time, the positions at the Institute are subject to the regulations of the Division of Mental Diseases which establishes
our working week (1+0 hours), vacation (15 days per year) and such
additional perquisites as my from time to time be allowed by
the Division Director (Dr. Ulett). In the event that salary
adjustments are approved by the Division Director or by the
Department of Psychiatry of the University, the stated salary will
be adjusted accordingly.

is

undergoing a

I look forward to having you join the staff of the
Institute, and trust that your visit to St. Louis provided you

‘

�October 13,

~2—

Dr. ‘Habib Nathan

with the basis for an affirmative decision.
Sincerely
Max

Fink,

Director

yoxms ,
M.D.

1961}

�</text>
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                    <text>December 11, 1969
Dr. Boris B. Hadary

Associate Professor
Department of Chemistry
American University
6 Nebraska Ave.,
Washington, D.C.

Mass.

~

N.W.

Dear Dr. ﬂadary:
Thank you very much for the invitation to participate
in a course in drug chemistry. I regret that I am unable to
participate as a guest lecturer.

In the event that the subject of

interest is our

work

on heroin addiction I would be pleased to recommend either
Dr. Richard Resnick, Assistant Clinical Professor, or
Dr. Arthur Zaks, Instructor in Psychiatry, both members

of this Department.

Sincerely yours,
Max

Fink,

2-4.1).

Professor of Psychiatry

MF:kp

�</text>
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                    <text>FwV—w...

«m;

,_

WWmW—m

www.2-

December 11, 1969
Dr. Doris B. Hadary

Associate Professor
Department of Chemistry
American University
Nebraska Avo.,
Washington, D.C.

Moss.

E

N.W.

Dear Dr. ﬁadary:
Thank you very much for the

in a course in drug chemistry.
as a guest lecturer.

participate
on

In the event

I

invitation to participate
regret that I am unable to

that the subject of interest is our work
I would be pleasod to recommend either

heroin addiction

Dr. Richard Resnick, Assistant Clinical Professor, or
Dr. Arthur Zaks, Instructor in Psychiatry, both members

of this Department.

Sincerely yours,

i

Fink, M.D.
Professor of Psychiatry

Max

2:}?

:kp

,..,...

.

�</text>
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Hr. John A. Hailey
The

state

Board of

Rogiatration for the

Hauling Arts of Missouri

Jefferson City, Missouri
Door Hr. Hoiloy:

Enclosed is the completed cpplication for licencuro
to practice nodioino in Hiooouri by endorsement of tho
National Board; and the too or $25.
My naturalization numbor is A~1h3186, dated
7 February, 1930, Philadelphia, Ponnoylvania court.
Thank you

for your cooperation.
Sincerely yours,

Hrtgp

cool.

ﬁnx FInE, M.D.

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metary
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Mr.JolmA.Haﬂoy

W
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Simly yum,
Max

Pink, PhD.

MW of WW

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                    <text>January

16 , 1967

Dr. Katharine H. Hain
Director of Medical Services

Schering Laboratories

1011 Morris Avenue
Union, New Jersey 07083

DearDr. Hain:
Thank you very mch for
on your oompoUnd, Etrafon.

the desgiptive literature

are establishing a laboratory for the continuing
studies of new psychoactive compounds in the treatment
of the acute mentally ill. In the event, that Schering
Corporation has novel compounds which it would like assessed
in out—patient populations , I would be pleased to hear from
We

W1.

Sincerely yours ,
Max

Fink,

‘

M.D.-

Professor of Psychiatry
MF:kp

:

�</text>
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                    <text>1'7”“?

m‘ .9“...

.7

~3.~

.w m—‘uw-

m. w

-

-4'\"A‘J_Vw—up~&lt;~uv--\'I"”“}~-—r¢-ruv

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v

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imp

7-7

w’w‘-m.mw—vn~wmv

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.(\.__r....-—...—-v-_—-"_w _. ‘-‘ nvr—
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w

Sepmnber 15, 1965

Dr. Prunjo Hajnsek

Dapmm: of Naming

University of Zagreb

and Psychiatry

Zagreb, Yugoslavia
Dear Dr. Hajnsek:

It was

a 3mm: pleasure to met you in Vienna, and to
listen to your presmxtationa. I becam even more excited
and find
whun I mad the latest issue of tho EEG
of
President
the Yugoslav Association
that you have been elected
‘

JW

for Electroencephalography. Congratulations!
Separately. I am sending you the reprints and the
bibliomphy which you have mmted. Hy best regm
to your associates, am! I look forward to visiting with
ywmuynexttriptoﬁmpo. I mutant sayingthat lightly,

fothopeﬂmtnuctsmrIcanbringwfamilymdthatwe
countries.

maybeable tomake
My
._&lt;_4‘.

best

atr‘iptotheﬁastem

ram.

Sinmmly yours ,

v

Max

Pink,

M.D.

meesscw of Psychiatry

HF:kp

vwww

a—u—u—v—w

—-

—

�</text>
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                    <text>rs—nynmvuw

Tuﬂm‘wwtﬁnwrx’u‘«WV-K14W‘m‘f'1m'ﬂ't‘W-Wlm

i

,

nul»w.
‘

-

,

mr

u— u

.
up“ r,‘rw

s—an,

r
.

“wag—.WWMv.»

w-

July 11, 1970

Peter Halasz
Budapest, Hungary

Dr.

Dear Dr. Halasz,
Dr. Volavka and I have reviewed your

credentials. I plan to

be in Prague

August 10 to 15, and am staying

If

letter

and

at the C.I.N.P. meetings

from

at the Parkhotel.

you can arrange to attend the meetings,

us an opportunity to discuss the programs of

it will

this Department.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

give

_

7,

”rm”,

»

--:v»-,_ hvaJI-"m‘ldrgwu

,2

�</text>
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                    <text>September 4, 1970

Peter Hales:
Ilnd Clinic of Neuropsychiatry

Dr.

Balassa—u 6

Budapest VII, Hungary

Dear Dr. Halasz:
I

regret

to Budapest

we

came

did not meet in Prague. Your
too late to allow a change in

letter of invitation

my

plans.

In the absence of a visit, may I ask that you send me a statement
activities,
of your interests, description of your hobbies and cultural
of
me
names
the
would
give
you
Also,
political iffiliations, etc.?
them
ask
to
may
work;
who
you
describe
or
can
your
three referees
write directly to me. I know Dr. Boszormenyi and perhaps you could
obtain a reference from him.
I look forward

to hearing

from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>October 11. 1976
Docent

H—1021

Peter Hales:

Hungary

Budapest

Dear Dr. Halaaz.

for your 1nqtiry. I regret that I do not
this laboratory at this time, but will keep your
file for reference, should an opening appear.

Thank you

’

have a pos1t1on in

npplication

on

You may wish to write to Dr. Jan Vblawka who is
gF'
3Q the Missouri Institute of
(5hoo Arsenal
~

now

Psychiatry
Street, St. Louis,
H1asonr1 63139) or Dr. M1chael Taylor (Professor and Chairman, Dyyartment
bf Psychiatry, Chicago medical School, VA Hospital,Ch1cago, Illinois),
[’both of whom are Innded for additional positions at this time.

i‘L

j

,

=

Sincerely yours.

,

Fink, 14.1).
Psychiatry
Progessorfof
:7
/” ,_._

Max

l
,

,

‘j’
'

.

1:”

�</text>
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                    <text>October 21, 1863

Mrs. Doris Haley

228, Renard

Room

4588 800155

Ibspital

St. Louis. Missouri.

M “1". Rainy!

my chuck #205 in the'mmt of $3.00
mpt
to cover mparmm memcm hm: Soptanber 23, 1963

Plum

through the math of October.
Thank you.

Slut-newly

Wm:

Q33:

yours,

Pink. H.
N
mmctor
~

Do

�</text>
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                    <text>)hy 25, 1965

Dr. (Earle: E. Hall

University of Pittabmgh
Projeat ‘Talmt Office
200 S. Craig

Stmt

PittsMh,Permy1vmia

mm:

15213

but
Immtoluwdnuycdﬂnmmmlettcrwlmg,
mhawaﬂyﬂmtlyewletodmmpmmmmtyofmologiml

Psychiatry-- acopyofmidlismlom.
unhittod in Catcher“ ampud for

‘Iheabstmct forﬁaismpoﬂ

Nation to their mating

was.

oarlicrﬂniamth.
Ihavemadﬂn prudictim paporwithmhintmt, mdampleased
that itwillbomndatﬁuAPAinSeptm. meaxlytoehnioaloomction
Imidswggest fwymmdmftismpnge 2. metastatic: should!»
Wsmmrimotl’aycimw“ mmdthetwodmgasmldbeidontified
'

as imipmmino (300 nag/day) and
(1200 mg and 15 nag/day).

chlwpmzine

..

procyclidina combination

Yowsuggoétimmgax'dingmaamimportmtfnctorinthisdataia

miwtmtm.mmmtmspeeialmisyougiwithnm.
to 9-40 cps and 25-413 cps for
m page It, discriminatims m
splmabo, md 3.4 cps for dﬂnrpmzina. This supports our

W

W

earlier canlmion based at the simple marina analyses. although your
mthod do“ so quit: alomtly.

uthat tha'EBG mew-13mm)!
wmtonpage
nine
is
intemomhtod,
mistmt with our analyses, for the intimFinally,

mktiauofmigrmwingtnqmybmdmmdariwdfmthemlog
.50 for widely separated
.95
bands,

My”: varies for
As

to

for neighboring

for your specific qmtims. I

am

ﬂattered to be midamd a

mo—

mﬂwrhutmhmﬂmtimluulyaia inabovem. mdcmoditslmldbe

mtaimdfwyomelf. Imldbohnppy forywtoindimtaﬂntthedata
111-2715
USPHS

was

Hillside Hospital, supported by
Wedto"at theFink.
D."

and Iii-072%

Hunt

M.

grunts

‘

mmmtingswﬂlndtbemmmdimeinaostmuorigmny

yplannd, minNmYotkinDncmr, probablyfollwingmm
Heating: (Bummer 3-41). The ate we not, as yet. been specifiad.

�Dr. Ha11_

Hay 25. 1965

~2~

ﬂbr'ancthcr report an tho relation of Eﬁsland psychiatric variables,
I also think it should be dons. chcvcr, thc Hillside data has been analyzcd
in many ways with vary few-behavioral -.EBG correlations ever successful.
As

Indeed. tho psychchxpkmﬂ.tnst - EEG data you and Dunn presented last year
is the principal "across disciplino" relation we have. I would have no
personal objecticns to tho rcranalysoa of the data, and.w111 be glad to
discuss this with you if you earn to visit St. Louis.

I want to thank you for your painstaking;wcmk.with Dean, and for your
kind thcughts in your vacant lcttnrc. My best wishes IOr success in your
ncw assignment.
Sinccrcly yours,
Pink. H. D.
N
Prafessar of Psychiatry

cc:

Dr. Dean Clyde

Biometric Laboratory

university of

Miama'

P. 0. Box 8293
Coral Gables #6, Florida

�</text>
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                    <text>June 1a, 1965

Dr. Charles E. Hall
University of Pittsmrgh
Project Talent Office
200 8. Craig Strut
Pittahmgh, Pameylvania 15213
Daar Cluck:

7

I haw: mmad your papar "A Techiique for Predicting the
Effect of Titanium“ with much intmst. I hope that you will
get a dimssim during the APA matings.
to the suggestion of publishing this in an
journal, I mndar if it would not do better in a
joumal mlatod
to psyohophamaoology? Could we not look
upm the EEG data merely as mpmmtative of a class of information? Your
my be equally applicable to other quantitative
data.
-

With regard

EBG~type

m

mm

If so, I

may“

mold auggest that you outwit this to Paychophamor Pamphguatag g. as two journals which an specifically

of intamst to scientists with
your article would u helpful.
Have

I

my

baokmmd and for mom I believe

visit with

would be pleased to have you
mo in your pmmtation.

us

at your leisure.

Sinoemly yours ,
Pink, H.D.
Professor of Psychiatry

Max

�</text>
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                    <text>‘

\

rw—mmmwwwz

l

i

July
Dr. Seorge L. Hall

26 , 1967

‘

C. General

Hospital
Psychiatry Mldmg

13.1

19th Street 8 Mass. S.E.
Washington, 13.0. 20003
Dear Dr. Hall:

It was a pleasure to speak to ycu last week regarding a
study of cyclazocim in the treatment failures in your present
oollalmtive depression study. While we had intended to
arrange a meeting within the next few weeks the various
vacation schedules precluded such a meeting.,
Since the schedules for early September are not yet
we have decided to defer such a meeting and. I look
forward to calling you again soon after Labor Day.

Wed,

I leak

forwaxﬂ

to meeting you.
Sincerely yours ,
Fink, ELD.
Professor of Psychiatry

Max

,

�</text>
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                    <text>Juno 10. 1964

Has: Miritn Ball
1206 south 59th Struck

Mllcvillo. Illinois

Boar Minn 3:11:

to having you join the staff of tha Psychiatric
Rolaarch 1oundntion and tha Missouri Institute of ruychiutry :8
Computer Progrnuanr«intly¢t, effoctiva an at :bout July 1, 1964.
at 5 minimum calary of $610.00 per month.

Hi loek inrwurd

In this position, 93 vauld bu pleased to have you participate in
the ruooarch programs and couputcr application of the studias of
tha nuntnlly 111, now undar chm direction of Mr. Don Shapiro, of
tha Computnt Canter of Wauhingtan Bnivnrsity.

this luttitnte are unbjcc: tn the rules and regula—
tians of thc Division of ”natal Diaaaaea of Missouri, which

Employaes of

providc accrued vacation time at the rate of 1~llh days par
touch, sick laawa at the rate of l—ilé days per month. and paid
holiday. as stipulated by the Governnr. During 1966 that: war.
can plid holidayn. Th3 watt watt is an hours. but tbs actual
hour; of umploynnnc will ho datcruinad by the neeés of thc prn»
gran. In guncral. they at. from 9:09 3.3. to 5:00 p.m., or
8:30 a.a. to 4:39 p.n. daily. A noou~day meal will be provided
it nominal cost through the St. Loni: State Hospital.

I

look forward to having you join the

staff.
Sincaraly yours,
Fink, M. D.
Executive Dilactor

Max

all)»
an:

Don

Shapire

�</text>
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                    <text>W

21, 1963

P. mm
mw
Summon Staff
Pacilitatiw
amt.

MP.

Edmtimml and Cultural Affairs
Dcpartmt of State
D. c.

Emu of

W,
Daur

RE:

IRS/3N

Banana Visitor Prom iP-nuaaas

M

Sir:

.,wgwishtospm
Ihdorﬁupmviaimsofﬁnmgem
J. Lang of
to the mind Status of Mr.

tho

Monica

Australia.

serum in

W

mg has bum invited to join th- Inatitute

7

Imuldbomtcful

Victoria, Australia. of this proposed application.
ﬂunkyouwx‘ymch.‘

Simuly yum,

Mum

mm.

as a mmamh

Why.ifywmﬂdmtﬂyﬂnomminﬁnlbom,
Mr.

m
M,
Mum:-

Ha Do

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                    <text>February 26, 196:;
Mr. Haloolm P. Hanan:

Dapartmnt of State

of Edumtimal and mm}. Affairs
Wu
Washington, D. C.

harm-.Hanam,
we was amming
No.

Prom
St.
at
W

scientists under Exchange Visitor
P414338 of 1:11: Missouri Institute of Psychiatry
State Hospital.
two

m3

Dr. Alemder Don is a resident of Bream, Essex,
England and will probably make application in

Wm.

and

m‘.

will

I

C. Holden is a resident of
probably make application in

J.

would be

warm if

you would

Iancashim, England

W1.
notify the appropriate

agencies of the Exchange Visitor mama No. Pull-.3388 mder
which these
are being recommended.

m

Mrzaw

Sincerely

yam,

ﬂax Pink,

M.

Director

D.

�</text>
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                    <text>February 27,

Mr.

196%

mmlm P. 3311“

Chief, Pacilitatiw Services Staff
Deparmmt of State
Affairs
menu of Edmational and

Washington, D. C.

20520

mum

Re: Exchange-Visitor
Pm‘gmm #9414338

Dear Mr. Ballast:

continue

The program

it.

run-3338

Please keep

is active

and wa are planning to
on thn established list.

this institution

'nankyou.
Sincerely yours .
Max

Pink,

Dimctor

M.

I).

�</text>
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-w

.«z'

'—y.&lt;- 1v-')vvv}ﬂ£vr ‘z’ibmu—Eﬂ'ﬁ‘vna'.r‘.Jvm'-vvwv—~"

—«.—-—.~r

..—..—.

,.

,-

7,.

.

m'v-r‘

,

rip-UI-w'nrwu-Vv-H‘w.»

..

u;

u

.n,/.,.,"_,.,.. in“,

,7” ,,,_

I

v

-.

wnw—ywwmvvwnwmww—a

.W.

November 20, 1978
mm.

Mr.

J. Heller

Efringerstrasse

Basel, Switzerland

Dear Mr.

Heller,

anv-wm-wrww-

m

um.

~v7‘w-w-"rnw'w

w

T3

CH-hOST

We

do not

ordinarily have funds for post-doctoral

candidates in our program, except for physicians who are completing
their psychiatric residency training. I regret that we are unable to
fund a position. We have, however, from time to time, made the facilities
of the laboratory available to candidates interested in examining a
problem for which these laboratories seem particularly well suited.
Our work is exclusively with normal human volunteers, almost always
male, and we are equipped to examine the EEG effects of psychoactive
drugs (or any other perturbation of the central nervous system) both
on acute and long term adminsitrations. While our studies are in
alert subjects, others at this University are exploring similar
problems in the sleeping volunteer. Should any of these facilities
be of use to you, let me know the proJect problem and if we can be
of assistance, we will.
=

Thank you

for your inquiry.

m.

we”.

Sincerely yours,

:xvvjyvvw-

Fink, M.D.
Professor of Psychiatry

Max

..

‘
H

“Tﬁfrvxﬂ'lz‘qr"arw'r‘w‘w-r-yﬂw'.

r9"

.

.._~

..

(

v

. .

c

‘-

7,.

.

�</text>
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                    <text>June 17. 1968
Dr. martin Halliday

National Hospital

Queens Square

London. England
Dear Dr. Hellidey:

recently visited your
laboratories. was diacuaeing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
Dr. Charles Shagaee. who

function with the unilateral and bilateral treatments.
are studying this prdblem and your experiences may

we

helpful. for Dr. Shagaee indicate: that different
memory tasks yielded differences in results for seizures
on the dominant and non~doninant sides.

he moat

If these reports are

indeed correct. I would be

grateful for e preprint of your report: or
published. the citation or reprint.

most

Thank you

very

much and my

it

congratulationn on

having made such a forceful impraeeion on

friend.

my good

Sincerely yours.
Max

Fink. u.D.

Professor of Paychiatry

Hakp

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                    <text>June 17, 1968
Dr. Martin Hallidsy

National Hospital

Queens Square
London, England

Dear Dr. Halliday:

'

Dr. Charles Shagass, who

laboratories.

recently visited your

discussing your program of research
in convulsive therapy and indicated that you had made
some novel observations on differences in memory
function with the unilateral and bilateral treatments.
We are studying this problem and
your experiences may
be most helpful. for Dr. Shagass indicates that different
memory tasks yielded differences in results for seizures
on the dominant and non-dominant sides.
was

If these reports are indeed correct. I would be
grateful for a preprint of your report; or if
published. the citation or reprint.

most

Thank you very much and my

congratulations on

having made such a forceful impression on

friend.

my

good

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

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                  <elementText elementTextId="101485">
                    <text>Kay

It.

8, 1964

Harold R. Hamilton

Clinical Coordinator
Rainier Laboruecricn. Inc.
1800 East Fbruhiag Road

Dncctur,

Illincia

Dec: Mr. Hamilton:

It:inatitution. While curly
clinical drug evaluasicn unit at thin
it was
my cupcctctiau thct an would conuidct Ic-379 first, Dr. earthen
has «apt-030d particular interns: in the other concound which
you dclcribcd to us, IHBIOGO. Bccculc of the similarity in its
pharmacological action to othcr canpoundc of particulur incarcat
to ac, um would likc to rcqucst c oupply of this compound, cpprox~
inntcly 3 grant. prufcrcbly in cclutioa, for tricl in our animals.
Indccd, if you are willing to capcnd this Itudy, wc should be
intnrcstcd in lane 9! ch. analcgc of this compound as wall. which
A:

In diacunscd noun wick. can, an

warn described

now

catablichins

an

in tbs brochure.

thiloving our int-:1 ctudicu. if IK~1060 dcnoncerntcc the activity
an anticipate, an would be intlcustcd in undcrtaking a clinical
drug evaluation.
thank you for your cooperation.
Sincernly yours,

Ha rink.
Dircctcr

ﬁlljb

K. D.

�</text>
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                    <text>March 21, 196M

Mr. Harold R. Hamilton

Clinical Coozﬂinator

Neisler-

IWtories, Inc.

W, Illinois

1300 East Pershing Road

Dear Mr. Hamilton:

associates and I have had an Opportunity to discuss the compomd,
find it of cmiderable intemst to us. I believe that
be
for us to undertake a pilot investigation in a
possible
itmy
small nurrbar of patients , using both clinical and alectmenoephalographic parcmetem, in order to define an answer to the queatim of

My

IN~379, and

whether IN~379 poaesses paydwotmpic activity.

so, requires the develotment of a suitable protocol, approval
Institute Pharmacology Committee , and the assigmmnt of a
the
by
mnber
to undertake the project. In order to provide a Ministaff
tivo answer, it will be necessary not only to mdevtake the clinical
amiss outlined, but also to provide some protection of our patients
by providing suitable laboratory safeguards.
To do

be possible to begin this study early in Jtme, since we will
It myham
to scan our ulation and find a reasonable sample.
fimt
Since the Wafer of pa ants to our wows my. in and of itself,
we shall have to urﬂermke the transfer first

have a salutary affect,
and allow a suitable period of obsawaﬂon before this canpomd

introduced.

is

-

of this factor, and the emmtim mat the drug 'mempy
be a minimum of three months, I believe the full study
will
period
will to” a period of six to eight mm. Homver. if you cm
supply :3 with son intrammus pmpamtlm. we will plan to undertake new pmlimlnary observatiom in a. laboratory setting to
the behavioral, electromphic. md physiological effects
acute
awnimmtim of this mpotmd.
of the
{Because

60W

�Mr. Harold R. Hamilton

3-21.“

Page We

studies - mum
thus, I believu that we ma undertake two separate
mom}:
dmmiu investi—
and
thrao
a
investigations in our hbarutory,
Would
me
to (ﬂaws your participation in
you call
gational trial.

this study?

Sincerely yams ,
Fink.
Director

Max

MP/jb

PM).

�</text>
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                    <text>July 1,

1964

Mt. Harold R. Hamilton

Clinical Coordinator
Dcportmcnt of

thicino

noisier Laboratories. Inc.

1800 East Pershing
Docator. Illinois

Road

m Hr. Hamilton:

is a provisional protocol for a study of INIOGO, prepared
Tho program will fit in as part of the ECDEU activ~
1:10: of this institute and as such will be sponsored in part by the

Encloocd

by Dr. Gerohon.

Psychiatric Rooocrch Foundation of Missouri. The additional cost:
for undcrtaking this study will be paid from the Foundation funds.
and I would like to request your consideration of a grant-in~aid in
tho sum of $A,OOO in rapport of the research activities of the
Foundation.

In the event this protocol is satisfactory and the grant~in~cid is

approved, 1 would opprecictc that the award be made in the name of
tho Psychiatric Rcoccrch Foundation and forwarded with a covering
lottor carrying a stipulation similar to either of those on the form
oncloood.
Both Dr. Got-hon and

I

would be pleased to have you

discuss this interesting study.

visit with

Sincerely yours,

no: Fink.
Director

zit/lb
En. c

M.D.

us to

�is pleased to

The

approve your request for a stant—in-ald in tha sum

at

3

V

for the general corporate purposcu of

the Psychiatric Rescarch Foundation of Missouri.

or:

...£or the research

and

training

programs of the

Psychiatric Research toundation of Hisaouri.

�</text>
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                    <text>_

5‘

Hatch 8. 1965

“to 382016 R. ﬁlﬂltﬂn
Clinical containntor
891313: Laboratorlun
1800 Poxuhin; Road

Ducaeur.

Illinatl

0“! Hr.

Hamilton:

bdhalf of the Psychiatrit Racaarch Foundation. 9. urn plu¢nad
dittd Boveubc: 16. 196k.
to soggy: your chuck in th. linen: of $2.000. As
you know. ch. roundnttan
for th. :nnc;rch program. a! the toundatiaa.
has but: acttvn in supporting the utudias :2 ch. nun Depart-Int of
Psychiatry a: th. Inititutn cf Psychiatry 0! ch. ﬂalvututty of His-curt.
It has bonn through thn coopurntion and assistanco of institutions
such 3: ch: Hui-lat Laborntoticu that has lid. possihla chc ttpld
growth at tho tttonxch programs of that center.
On

[knit you vnty unch for your assistanca.
Sincnrlly yours.
Ha: Fink. H.b.
Kxucuttva Diroccor

Hrs}:
ea:

Br. Blue:

nr. earshot

‘

‘

N

�</text>
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                    <text>w."

WWM',

June 7, 1972
Mr. John A. Hamilton
New
New

York Times
York City

Dear Mr. Hamilton,

1

I very much appreciated your balanced presentation of
the problems inherent in a heroin delivery research project in your
article, Free Fix fbr Addicts ? on June 5. In addition to the problems
described by Drs. Jaffe, Dole, and Phillipson, we should add the special
risks of heroin administration. In our studies at this center, we have
used 'heroin challenges' as a specific index of the duration of action
of narcotic antagonists. This experience has brought to our attention
that intravenous heroin has effects on heart rate and the EKG; on
cerebral rhythms (exciting seizure activity sufficient on at least three
occasions to precipitate a grand mal convulsion); and on respiration.
The sequence of events are often unpredictable, since the men vary in the
degree of the induced cross-tolerance to opiates they have developed.
Even in the laboratory, there are problems; we are not sanguine about
a large scale delivery system.
Indeed, rather than seeking the use of shorter acting
opiates, as heroin or morphine, there is logic in seeking opiateelike

with durations of activity longer than methadone. Levomethadyl,
the l-alpha-acetylmethadol, is such a substance. Instead of seeking the
use of a short acting substance, the leaders desiring to innovate might
do well to look into the greater use of this substance: by providing a
longer duration of cross~tolerance, dosages must be taken only three times
a week, reducing both the problems of irregular intake and that of
'seepage' of illicit materials into the community. Levomethadyl is
also taken orally, as is methadone.
compounds

Again, I wish to commend you
heroin delivery recommendations.

on a reasoned view

of the

Sincerely yours,
Fink, M.D.
Professor of psychiatry

Max

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                    <text>Hard) 15 , 1967

Professor Max Hamilton

Department

of Psychiatry

The University
15 Hyde

Leeds

2,

of Leeds

Terrace,

England

DearMax,

It was a most pleasant surprise to receive your Jdnd letter
ofMarchS. Itisanhonor'tosendyoutheenclosedoopyofow
lSDmpor-t. Ofmnmiypaperstlutmyassociatesandlhave
written during the past decade, this has excited the most interest
and it is smprising, forwewrote it inresponse to thepopular
interestayemagohopingtoimpedethsgrowinghysteria. We

havebeenunsuooessfularndISDisaspopularinNewYorkaspout

sluetsatamcetredc.

.

Myfanilymdlammostpleasedtobebeokinﬂubigcity
will

it

another year to re—establish my
probably t
Optimistic that I will be able to continue the
study programs which were so successful in Missouri.

and while

laboratory, I

-

am

WrenyouplmtoconetoNewYork, Ihopeyouwillhavean
visit me. Surely, one of the main benefits of
being in New York is the focus it represents for intemational
travelers.

opportmity to
My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

14sz

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                    <text>March

4, l968

Dr. Max Hamilton

University of Leeds
Department of ngchiatry
l5 Hyde Terrace
Leeds 2, England

The

Dear Max,

of you to think of me, but I know very little
about the University of Vermont. It is among the newer schools
situated in one of the most beautiful parts of the East. Skiing
in the winter and swimming in the summer are within twenty to
Boston and
thirty minutes of the city. It is well located for
between
talent
there is an active change of professional
Burlington and that city. As Albany achieves greater prominence
in medicine, perhaps the relationship will shift to New York.

It

was kind

recollect that George Brooks was active in that area and
perhaps you would write to him for more information. Perhaps
the best source would be still be Milt Greenblatt who seems to
know everyone in that part of the country.
I

Incidentally, in the same mail I received a letter
student, Clive Tonks, who is writing with regard to the
in menstruation.

from your
EEG

changes

Perhaps we will meet in the forthcoming meetings in Tarragona.
In the meantime. my best personal regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 19. 1968

Professor

Hex Hamilton

Department of Psychiatry
The University of Leeds

ls

Hyde

Terrace

Leeds 2. England

96‘!

Max.

I have received a telephone call from Nathan
for

if

I had room in my laboratory
Hamilton's by the name of John
a disciple of
Nicholas Hall. Of course. I said yes. When I
is
called George Simpson he told me that ur. Hallcoming
in
who
is interested
a clinical psychologist

Kline asking an

Max

for three months.

I have missed talking to you over the past few
years. but I have not remained idle. This laboratory
has an in-patient and outvpatient component focussed
at
on narcotic addicts and psychotic-z a study in ECTEEG
for
a large private hospital: a computer facility
analysis and other data processing: and assorted
psychologists. residents. 25g.
If ur. Hall is interested in working in the kind

of a show that I had at Hillside. but immeasurably better.
is one problem
I would be pleased to consider him. Thereand
with
if not from
which I would like to have some help
have
we
him. perhaps from one of your other sorters.
been using the Hamilton Rating Scale and have written a
kinds of depression
seall program to classify differentitems
of historical
seven
adding
from that scale after
of
depressives.
information. I have a large population
(we
fun 50
both before and during convulsive therapy
treatments a day). at this point I would be interested

�d

Professor Hamilton

—2—

June 19. 1968

in having codibody work with my residents in the
proper application of the scale and in exploring
its diagnostic and even some of its predictive
features. surely. I would not restrict the work
to this scale elone. but would be pleated to use
some other measures.

tell: no that Mr. Hall would like to
in
curly
July for three months. I think three
months is somewhat short. especially over the summer.
but I would be glad to entertain him for that period
if you think it would he mutuelly useful.
The next time you wish to send someone. perhaps
you would think of no.
my best personal regards.
come

George

Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

MF:KP

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                    <text>November 19, 1969
,

Professor

Max

Hamilton

Department of Psychiatry
University of Leeds
15 Hyde Terrace
Leeds 2, England

Dear ﬂax,

of you to visit with us and to permit us
to tap your experience and wisdom. My associates and I think

It

was kind

you.

I
way we

embarrassed about the hotel, for that is not the
ordinarily treat our visitors.
am

Please accept the enclosed as

expenses.

a token

to defray your
~

Sincerely yours,
:
m—m

Fink, M.D.
Executive Director

Max

Mszp

�</text>
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                    <text>ww.~mvmmhr'7Vw'.

erw—Il-‘HW

W

m

February 3. 1978

Professor

Max Hamilton.
Department of Psychiatry
Leeds , England

Dear Max,
We are pleased that you will be able to visit us again.
I have arranged with the Director of Residency Training, Dr.
Lester Shapiro, for you to lecture to the residents on Thursday,
March 2 from 1 to 3 p.m. If agreeable to you, we have provisionally
titled the presentation as "Diagnosis and Treatment of Depression."
It is important. we believe. for these students to have another
point of View with regard to the issues in the identification and class—
ification of depressed patients, the treatments that are available.
and the decisions involved in their care. If possible, it may
be helpful for them to hear about the development and your view of the
present status of the Hamilton Depression scales.

and

Martha and I would be pleased to have you stay with us,
you to the University on Thursday. We

I will arrange to take

can make the

final arrangements in

New

Orleans.

I am processing the letter from your registrar and I
should have an answer from the Department within the week. I have
recommended that an invitation be extended to her, and would like
to have her assistance in the clinical research unit at the VA
Hospital in Northport,

centers.

New

York, one of our

affiliated clinical

.

I think

we

will

have some fun

forward to seeing you there.

My

best.

in

New

Orleans and I look

Sincerely yours,
Max Pink, H.D.
Professor of Psychiatry

cc:

L.

Shapiro,

H.D.

W3 .—..~... ",7. VFW—7m—

�</text>
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                    <text>it!

January 22, 1985
Max Hamilton, MD.

Psychiatry Annexe
University of Leeds School of Medicine
30 Clarendon Road
Leeds L52 9N2

England

Dear Max,

Martha and I, as well as many of my patients, enjoyed your visit this past
week-end. After you left, 1 completed the review of the meeting, and sent it on to
the publisher. Vol I No. l is now complete. Thank you for your help. I enclose a
draft for your information.
Thank you also for the updated copy of SCHIZOPHRENIA. It remains a
valuable contribution to our limited knowledge about this dread disorder. In reading
the section on treatment, I am disappointed with the short shrift given ECT. The
young man you met on my service, Mr. White, clearly suffers from this disorder.
The remarkable change in his behavior was not achieved with any drug
combination, and when ECT was proposed, as a 'last-ditch effort', his family
demurred for more than two months. Now they are delighted, and even if the
improvement is transient, and allows him to be home for only a few weeks, it still
remains a miracle to them.
I

have taken the liberty of writing to your publisher.

My

best regards, and my thanks for your help in CONVULSIVE THERAPY.

Sincerely yours,
Max Fink, M.D.

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DzuHGIJJn

Laboratories
Wt
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6

Norm Mango,

Immia

Bond

DaarDr. Rubia:
At the

sumestimofw. JmamanCole Imwx'iﬁng
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Inﬂuemntﬂxatthiamndismadeavailablefor
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�</text>
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Hrs. JoAnn Hammell

Scottsdale Jr.

Women's Club

8632 East Keim Drive

Scottsdale, Arizona

Dear Hrs . Howell:

In reply to your inquiry for information to support
your newly implemented "Dope Stop" program, I am pleased to
enclose reprints of some of our recent work. These will
indicate that a useful approach in the treatment of opiate
addiction is the pharmacological antagonist model. Good
luck in your new venture.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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Irs.

JoAnn Hammell
Women's Club
8632 East Keim Drive

Scottsdale Jr.

Scottsdale, Arizona

Dear Mrs. Hammellz»

In reply to your inquiry for information to support

your newly implemented "Dope Stop” program, I am pleased to
enclose reprints of some of our recent work. These will
indicate that a useful approach in the treatment of opiate
addiction is the pharmacological antagonist model.
luck in your new venture.

Good

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>.-v.w.r~~—.~..m.

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V0.

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.

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.w-w—w-q-waw-s-u

'niW-z-I».v
‘E'w,r'-.-n“~"NM‘KNV‘TJJW'S'W'

June 9, l970
Mr.

Polar

Hammond

Execuflve Director
Naflonal Coordinafing Council

Sulfa 2l2

i2il Connecflcuf Ave.,

Washingfon, D.C. 20030

N.

Dear Mr. Hammond:

in

Enclosed is a shorl biographical skefch for your use
for the Naflonai Coordinailng Council meefing in July.

PR

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlalry
MF:kp

one o

.u

,-

.‘r:«-‘4

u...

-ur V,,_‘,.....‘

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                    <text>_WW1

June 9, l970

Polar

Mr.

Hammond

Execufive Dlrocfor
Nalional Coordinating Councll
Suite 2i2
l2ii Connecflcuf Ave., N.
Washingfon, D.C. 20030
Dear Mr. Hammond:

in

PR

Enclosed is a shorl biographical skeich for your use
for +ho Nafionai Coordinating Council meeflng in July.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlairy
Mszp
60C.

�</text>
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                    <text>V

..

November 12 , 1965

Dr. A. J. Home
Department of
School of Medicine

WW
miwmity

Stanford
Palo Alto, California

Dearl».ﬂanoe:

r

mu C.I.N.P.

.

..,A

,._&lt;.Aw,...,“

,.

for the ferthooming mating
.mttse
Prom
asked Dr. Philip Bradley
1966
has
and":

2841,
in Washington on
and wool! to arrange a
loy. We have decided
subject of:

‘

topic of neuroswimto on the gamma
on the
symposim
mgr a

,—.nn.,—.Y&lt;..A.A..,._.A

-""'"”,

Mtiol'xolimrgio hallucimgens have moeived considerable omdy
and tho data relates to the problem of oentml nervom syntax
cholinergio Wartime in the therapeutic effects of various
somatic trauma-its , and to the special problem of the dissocia~

tion of

EEG

and

mavior.

‘

experience with the” Wards and your
interest in these problem we wwld like to invite you to

Walrus-your

participate in this
1.

If you an

symposims.

able to swept this invitatim,

would you

please send me a proposed title for your pmsmtation, and a
shortperegmph doeozibingthefows mdtypeofdntayouwish

to

want?

-

and I
receipt of truss adomledmnts , Dr. Bradley
time
for
program balancing the
will mks up a
has
The
C.I.N.P.
and
Mitten
dismime
pmmtatiom
agreed ﬁrst this symposium will have at last me session of
simltmeom tmsletim, so that reports may be presented in
of yam- amiss.
the
2. the c.I.N.P.‘ has not stated a general muoation policy
md we pmposa to publish those reports and dismmsiars as a
Upon

Wood

1%

separate volum.

‘

0.1.83. antioipatas that each pmioipmt will pay
hisomexpmsesinattmdingthismting. Yorthosesttending
from Emopa, a mortar flight may be organised by Dr. Philip Bradley.
3. the

�h

Dr. Hmee

November 12, 1965

~2~

In the event that travel funds areneoeseaxy, please indicate the
requested to supplement yous? aveileble funds and we will
these requests to the Prom end meantive Comittees
for their deeieim.

wt
Wt
a.

The

are being

emittee

made by:

has asked that

we

indicate

mgements

Kiss Margaret K. Taylor
ole 6.1.“.1’. Secretariat
363646131

Street,

NM.

Washington, 11.6. 26010

If you are plaming to attend this
dimotly?

meeting, would you write to her

Dmm'adleymdllookfmemmhavingywjoinueinﬂxis

Waive»

Sincerely yours ,
Mex

Flam-Mm.

meessof of Psyehiatry

�</text>
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                    <text>:m—y:

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r

m” ..'.,_..wm

v. .,~.—w..:-...

Wu.

i...

—.

\mw—mwnwnv .

V

w, was"

“.1...

V

..

., .—.__.__s.—.v_ WV ....._.~_.a v...._.._..__.._._r‘

April 28. 1969
Dr. 6. Richard Hendrick. Ph.D.
Arthur 0. Little. Inc.

Acorn Park

Cambridge. Massachusetts 021d0
Dear Dr. Handrick:
Thank you very much for the analysis of our sample of
It was most useful having the assay from ﬁrs. Manion

A9-THC.

and Efren.

It is

my

interpretation of the data that there

has been a degradation of the a9-THC and for practical purposes
reduction has been approximately 10% with increasing amounts
appearing as a“ and N-3.
In retrospect a possible explanation for this degradation
has been that our samples have been maintained at approximately
5°C. which may not be adequate.
we

are very grateful for your help.

"Yﬁmwxwmamm

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max
rtwcsz-wmn

“are

"I!“

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1-

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�</text>
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                    <text>lovodbor 3rd. 1972

Dr. Edward Eunin.

Director,

,

Divinion or Payohintrio Trtinins and Education.
at. Vincent's Hospital :nd Hodiool Canoe: of H. Y.,
lhh whit 12th Etta-t.

new

York..l.r. 10011.

Door Doctor Bunin.

I would be pleased to portioipote in one of your
departnonﬁnl conforonooo. I would nascent either
rhbrunry lot or 8%h. 1973.V During my last visit. I
tglkod thou; narcotic Inttgouinto. and if you would
like u followup on than. us toll :- lovonothodyl, I
V111 be also to present the rectum data in u talk
entitled "Roeont rosooroh 1n opiotc.cdd1et1ou”.
Altornnttvcly, I on now involved in unannristnc
dot. tron 3 recent contoronoo on clootrooonvuluive thorapy
god it might be astral to prosont the theorion cod
neurophysiology of HOT 1n n tolk entitled ”Boas clues
to tho avsoory or BUT”.

I

hnvo

recently coooptod an appointment ut the

Btoto Univcruity of

b.

moaned

st

new York

(516) hamzhlw.

It

Stony Brook, nod

I can

Binoorcly yourl.

ﬂax

rink.

M.D.

Proton-or of Psychiotry
Hf/id

�</text>
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                    <text>i...

.w»....

‘/'

1;-

.W.

._W,

,—
&lt;

-.

x»

”we

—m-,n..y

W

‘z'n'vw

WWI-curv-

mmm

“W

May

”WW

r"

13, 1978

Edward Hanin, M.D.

St. Vincent's Hospital
Harrison, New York
Dear Ed,

I am pleased to write this letter in support of the
application for hospital privileges by Arthur Zaks, M.D.
Arthur was a resident in psychiatry at the New York
Medical College about 1968-70. He undertook clinical research into

the mode of action and utilization of narcotic antagonists and
opioids in the treatment of opiate dependdnce, and following the
completion of his training continued as a member of the Department
staff. His research included the assessment of methadone and
levomethadyl in opiate dependence, the use of heroin challenges,
and the use of naloxone in the management of opiate overdose and
as a possible treatment method. He has published extensively.
In this work, he was diligent, responsible and a most
capable clinician. After entering private practice, he continued to
carry out research projects with NIMH support, the last continuing

to

my

knowledge

until

1976.

is an able teacher and an outstanding clinician. I
without reservation.

He

recommend him

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>of Psychiatry and Behavioral Science
Sciences
Helm
Center
37'. -:c University ofNL-w York
at Stony Brook
D’i‘f‘zlll‘llllL’PA

3‘ “n1;

Book. New York 11794-8101

Iéienhone: (516) 444-2990

StonyBrook

April 24, 1984

Israel Hanin,

Ph.D.

Professor of Psychiatry,

Pharmacology and Psychology

University of Pittsburgh
3811 O'Hara

Pittsburgh,

Street

PA

15213

Dear Dr. Hanin:
I

am

Thank you for the invitation to
unable to accept your invitation.
Good luck

visit

in China in October,

in your fine work.
Sincerely,

Max

Mcmjp

Fink, M.D.

Professor of Psychiatry

�</text>
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May

W
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MP.

Wild

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W3, WW5.

Cat

Smith, Harris 8

Mar Harold:
with plmm'e and gmtituae
It is$100

butim of

from yes

that, I meept the commof
for the Peyehiatrie Research

mum

Psychiatric Research Fatwatim is indebted to yen. not
but alas for the support, time and effort
you have crammed during this first war 01' the Emulation'e
organization and
The

only for

this

men.

Win

It is anticipated these funds will he used ta support we
scimtists in developing their new research prom fan the benefit
cf the mtally ill of Missouri.
‘

‘

New thanks.

851ml); yours,

m
m. M.Director
Executive
De

[4me

'

�</text>
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HP. Eiarolé Hawks
8 Eianke

Smith, Harris

_

Mbaaw v Bnildn' :g
51:.

Louis. $830M

Dear Harold:

ngmm applicatim
Mam
in August.

Encloaod is a copy of the
whidx you were kind enough to 85.571
chance

first

butIdidnothavea
watmwusmmwsm,
todigmsa thiswithhim Iwilldosoatthe

opportunity.
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best

‘

mm.
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                    <text>.W

18, 1963

Mr. Harold C. iianke

Smith, Hard-.8 6 Hark:
I411 Norm 7th Street

St. Louis 1,

am

Dear Harold:

is to cmfim m appoinumnt to meat with mpmun—
of tho
tatim 0f the Mental Health March hard Coumitm
December 16
This

Natimal Institute of mm Realm on
9:00 awn. at the Fomdation off-lee.

My,

, at

I amiapam two viaitm farm that orgmimim, Dr.
Stein of Com]. University, who is a mum:- of the Camime. and Dr. Betty Piekatt, ﬂu emittoo'n Emtivc Smtar'y.

W

Xanticipatc thatmshmldbeablo
qmtim in half an hum.
Many thmks for your help Thursday.

tamalltmir

Simmly yours,
Max

Fink. H.

D.

Emcutiw Dimctcw

Willa

�</text>
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                    <text>Ketch 2. 1964

Hr. Herold 0. Route
Smith. Bertie and Kenke

Suite 808 Ambassador Building
All North Seventh Street

St. Louie

l,

Miolouri

Deer Harold:

is always true. we have most need of e lawyer when he is
on vacation. I hope that you have enjoyed yours. I would
be most grateful if you could tell no prior to the board
meeting, at there are e number at problems which require
clerifieetion.

A;

'

I believe that we should go ahead with the program of on»
lerging the board, even though the illness of Mr. Bethe will
prevent the innediete enlargement. Bovevet. if the notion
of the board at this meeting will handicap ite action because
will enletge the unober oeoeeeery for e quorum, nerhepe we
it
should defer thin action until we ere reasonably note that we
have condidetee to fill the additional positions.
We

hove had no odditiooel information from Mt. Trigg.

At the

present time, George is noting on if the reletionehip to the
State will continue in on independent feehion; howeVer, he
has been very actively involved with the University of Mieeooti
end in trying to eetehlieh e relationship with that university.
since our attempts at relating to Washington University have
failed. There in none possibility thet if we relate to the
University of Hieeonri. the position of the Foundation would
have to be reviewed.

Theee ere, however, not the problem: which face we at the
moment. I have e problem with Monsanto Chemical with regerd
to out one of eons of their compounds in eXpetioeotel studies
which we would like tomoderteke. I have written to then to
obtain their support in providing on with the new materials

necessary for this Study.

�Hr.

He Cs

3-2~66

Pegs

amt.

Two

I have slso mode so inquiry regarding the feasibility of s
formal ststeosnt from honssnto Cheeicel to the Fonndstion,

regsrding the contingency that these new conroonds may be
highly successful in the treatment of the mentally ill.
It so, I would like to be sure that ell financial benefits
do not sccrue to the private corporation clone. Most'of
the funds used to study these compounds will cone both from
the Stete of hissouri end the National Institute of Mental
Health. I have been siogclsrly unsuccessful in obtsining
their help. even to discuss the question of a formal relation~
ship between the chemical company and the Yoondetion (Institute).
I would be grateful for e few minutes of your time to discuss
this problem end. if necessary. to bring it up before the bosrd
at its meeting on the 13th.‘
‘

second problem is not related to the meeting; but has become
urgent heceuse of some actions in the Institute. Last summer.
we were critically short of en EEG technicien. we advertised
in St. Louis and lot it be known throughout the state that we
would like to employ a technician. None were available. 1
sdvsrtised in Greet Briten and received e number inquiries.
Hy

girl was appointed, but this ﬁne insufficient for our needs.
student at Hsshington University who was here on 3 student vies
wee brought to my attention as someone who was well trained in
electroencephalography. I made inquiries end suggested that she
work with us. She indicated thst she was unsble to sccept any
payment because the lea would not permit her to work, since she
One

A

was on on exchenge

vise.

She began to work with us on the heels that if she obtained permiesion from the inmigrstion authorities, we would he eble to psy
her rstrosctivsly. The spplicetions hsve been cede, and there
hes been considershle communicstion between the University. the
innigrstion sothorities. end my office. This week, we received
final notification thst the immigration authorities would not
sllow her to work.

is en excellent technicisn. She is shle to work on a 60:
end hes usintsined her schooling very well. If I celeulste
the suns owed her to dete, it is epproxiaetoly $2,000. I do not
know if it is worth another effort. but I an aware that en inquiry
from an attorney cerriss considerable weight with cost lower
echelon sdcinistretive people. I should like to discuss this
problem with you, and set your advice as to whether we should or
should not attempt to obtsin e change in ruling so that we can
continue to obtain the services of this excellent worker.

She

hssio

�Mr. H. C. Hunk;

3-2-6‘

Page Throo

other unyl. tho program 13 going along excollontly. Ho
have recotvod an award from a Malliookrod: Foundntion to tho Inn
of $2.500. Th1. will be used to luppott tho crsvolina expenses
of the pharmacologiat from Australia and lenvo us with an additional fund for tho Foundation'l «:0.
Plano: call I. if you can heforo Frldny. I an aura that I will be
onvtous of your cunt-n. My boo: regards.
In

many

Sincerely yours.
”ax Fink, "on.

Director

um»

�</text>
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              <elementText elementTextId="9222">
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                    <text>W 17,

1.95%

an W
Mum

Mr.

C. Hanka

7th Sweat
St. Louis.
233.

Dear Harold:

menbarg regarding
Winampyofalntter {m
Wmoftmnallindmdtm.
believe that m Md not dusimteInviawofthislettw,l
m. Lang as a MlinWt
Palm. It 15 beliaf also, that the
111*.

'
A

~—r

A

--.«&lt;~&lt;

‘\&lt;'I

WW me

my

mum wizardry in the m of the m5.
Inlimwiththis,1henew1myinolmﬂnfullmmtin
is

Inmby givimg us

WWOfﬂwMtMnmmmpaWemm.
Iwillwitatobr.mwommdomfimtms.
'

.,-v~

.

H",

,v‘rWI‘WA'v’.‘

Famﬂaetieany, the

problem has been remind
mimity
all argued

that m atfﬂiatim
We
inimmiblefwﬂapmntandﬂmtmwiummm

ﬁrm

my.

W3

have

later an this war.

sincerely
Mm:

Mm»:
Venn.

Fink.

ms.

Wm War
M. D.

�</text>
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                    <text>March 23, 196k

untold c. Hank:
Smith. Harris and Hanks
411 North seventh Street
St. Louis 1. Missouri

Mr.

Dear Harold:

has leccptud thn Foundatlods invitgtton
enclonod
tho
in
letter. I believu it woulé be appropriate
for us to invite him to visit the qutttute and to bacon.

Mr. L‘nganbutg

acquitntad with the complex Institutenroundation relationships. I would be planted to do thin or, do yea think it
not. appropriate for Law Stunt: or yourself? After you
have givun 1: tan: thought, ploaoa call an.
Sincerely yours.

ﬂak,
m
Diraator
HF/jh

My».

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                    <text>March 25, 196“

Mr; Harold
N. 7th

an
St.

Louis,-

c. ﬂanks

Street

'

Miami

Dear Harold:
Enclosed is a copy of a contract that I would like to submit
Dr.
Gilcha. Quimn of the Ihntal Health Planning for the
to
State of Missmmi. I have stmm him this fem and the attached
budget. It is necessary that an offimr of the medation sign
this, and I would be grateful if you would dc so, and mtum

to

it

me.

enclosing a cam copy of the budget and a
of the cm’cmct for your files.

I

am

Xemx copy

'

Thank you" very much.

Sincerely yours,

"E's-aw

em.

Max Fink, M. D.
Executive Dime-tor

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                    <text>January 25, 1965

Mr. Harold C. Hanks

Attmxeyatlav
with. Hands
all N. 7thStreet

em
WWW
St.

11min,

mam

Deer Hunld‘:

Ihewmadﬂlemeepctmoebetwemeeorgeand

‘memtbetwemtheamtmof
mmimtyofmwﬁmmehymmcw
Fomdation.

ymelfm

Whimaagz'eethetmumtmhagbem

ﬁnDemefﬁnMieelSdml.ﬁ1eDdreetorofﬁu
with
Divisimofhntel

Diseases. mdthel’omdeticn

maﬁtoﬂufeciﬁtieeofﬂninspitalmtmmferofgmnteelmedymedewwldbehelpful,mypm~

vieiawdzichmyliﬁttlmfmdmieingeapecitieeof
the Pamde‘timwouldminlmlzeitelmgme mfulness.
Specifically, elimitetimthettmf‘mdxtimcmnd

,mlmgereolidtmtsﬁmtlmfedemleovenmnt
the best interest of the

to
Itmybetoevezyme'aedvmtegenotto
PM.judicial
activities in

my

the Pamdetim‘s

UNA:

any specified

wayatthiaearlydnte.

Sincerely yours ,
Dr. Max Pink

Pﬁzjm

cc: Dr.

Executive Director
George A.

Mr. Lewis B.

Ulett
Stuart

.

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                    <text>mg... .a-mur.w.,.wmwy:--.~..w

April 8,

1965

C. Hm, Vice Prusidsm:
mm
8 Home;
MamiMm.

Mr.

an

St.

m

71:11

Strut

1. Missouri
Burnt. Ham:
“mo mt mating of tho Board of Directors of the
of Missouri has pmvisiomlly
Psychiatric Mara:
been set for Friday, June a. 1965, at 12:30 pm. at the
Missmri Athletic Club. If than is
problm wiﬂztﬁis
Lewis

mum

data.‘wou1d you

m

plans can my attics?
Sinamly.
”all

Mijm

M’ H.D‘
Dimmr

Emoutiva

.

.....~.r

�</text>
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                    <text>I,

June 23, 1965

Mr. Harold C. Hanks

331th.

lands

#11 N. 7th

St. Louis,

8 Bake
Street

Miami

Dar Harold:

mimions
mgamding our overhcad allomce. Also,
Mon
aprwiaiamlhttcrmichlmldliketomdtow.
Finland are ﬂumofax copies of the

with ﬁr.

Stmttcn is «reload.

pleas edit this letter
into the tcdmical language which will
best
pmtoct the Fundatim's intemst?
I monived your letter and Hr. Sachs' ahedc this

and comer“:

it

Would you

-

naming and join you in yum cxpmsaion of meant.
Sincerely yours.
Pink, H.D.
Exemtive Director
Max

Hchp

mlosums

�</text>
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                    <text>August 25 , 1965

Mr. Harold C.

Smith, Hurt-la

Hm
S Hades

ﬁll :‘aéort‘h 7th Stu-t
St. [min 1, mum

mmm:

W'
mat
"leforﬂming‘ﬂnntalihalthl’mgm.

the

The ‘Psydziatrlc

Pandatim has remind in full

of $7,900.00 which has

in the

first installmt was waived on

wt

The

in tha

boon paid from

mm:

Missouri's

,

Dam 5,

1961;

of $16,709.00, md the seemd on Jun 3, 1965.
of $3,191.00. I do not ham a facsimile of the

mambutﬁninvoimclwlystatodmtltminpmnt
with Dr. Gildu's

of the

mm

prom.

buylmﬁxiaopmmitytomindywmttho

W‘Cmmmpmhmuﬁnmxtmﬁngof
the PomdatimmOcztobcr 8, 1965. miswill muim

not only for
Miami
aswcll.

Board when but

officers

I will be attmding the Intamtional EEG Meetings
and continuing my public relations
on helm]! of

pm
mdexpccttorvtumtoSt.LoulsabmtSeptexmer15,1965.
ﬁnfwmimmdtluInBtitutcdm-ingﬁumxtfewmks,

you have had a plewt vacation.
Wt
regards.

I

My

best

Sincerely yours ,
ﬂax Fink, 14.1).
1117:3111

Executive Director

�</text>
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bywvn-‘mxww

‘3”.

Homber 5 ,

1965

“by Harold C. Hanks
Smith, Harris a Hum

1611

St.

SW!
M1 1. “15:
am
N.

Dear.-

7121'!

Harold:

Plane simuViocpmsidantonlim2ofaachoud

and each form.

Sincerely.
Pink, PM).
Bancutiw Director
Max

NFﬁm

�</text>
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                    <text>{5

January 23, 1962

Dr. Leon Banker!
Department of Psychiatry
Downetete Medical Center of
State University or N.Y.
hSO Clerkean Avenue
Brooklyn, H.Y.
Deer Leon:
Some months ago you enquired about
in psychopharmecolegy.
I am taking the

EEG

studies

liberty of
sending you this draft copy of a summary of our studies,
with my View of the present relevance for the field.
The figures are still at the photographer, and I will
send them to you when available.
My

regards.
Sincerely yours,

Mthp
ﬁnale

.ex

ea

,‘ﬁ.5.

�</text>
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                    <text>w-*

r" vx-r- ww-xu-

’Wp‘WI-WF'HM'MV

w

ww'Wv-x-x

av»
‘T‘VF‘,‘¥ZV*I‘i‘w‘wwnllm-ww‘,w~~

-

"7.":"m‘limwww-m&gt;1.

hoVembor

l,

V7-I-‘ﬁ‘m'yn-v—Vuw-0.1.9....mr ,

n...

“a“: ,7... amp.“ ,wwwmnnquw—am

1967

‘Dr. Leon D. Hankoff

hirector, Department of Psychiatry

Queens HOSpital Center

7

'Queens General Hosoital

82~68 l64th

Jamaica,

ﬂew

Street
York

Dear Leon,

for accepting our invitation to share.
Mental
Health Clinic, your imoressions of
of
the
staff
a psychiatric satellite clinic operation. As I mentioned, I.am
interested in having observers of the Mental Health Clinic share
their experiences with my staff3.as we struggle with the develoo~
ment of a program in this Hospital. The meeting will take place
at Metropolitan Hospital, 97th,$treet’and Second Avenue, on
Wednesday,~Nohember l5, at lD:OG am. we will meet in the clinic
on the lSth floor. The meeting_will be quite informal with a
orchable attendance of twelve to fifteen staff membors;
Thank you very moon

with the

Following your request, I have asked 9r. Robert Sharoff to
with
meet
you earlier at his office on hard lSA.‘ This is one
of the psychophannaoology study units-and is dedicated to the
study of new drugs in the:treatment of addicts. He will share
with you his extensive experience in many treatment attempts~
with this population. loam taking the liberty of enclosing a
copy of the report which has Just appeared in the J.A.M.A. which.
describes our most recent experience.
-

'

time permits, 1 would be pleased to tell you of our more
work
with naloxone ~ studies that have been suspended
recent
because of a shortage of medication ~ a shortage which I hope is
temporary for this work has been most exciting.

If

'

Thank you

for your willingness to visit

With us.

’Sinoerely-yours,

'

MF:kp

Max Fink, M.B.
.Professor of Psychiatry‘

�</text>
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                    <text>{‘7'

:w-VI’v-I: .-.

7-K.

1r»

'T—m mwv'r-

-

a

.w

as «w- &lt;v w.»w~.-..V,-mv---m-we ,

~

“4“:

.

.

.—._-

rg...‘w-;;me WV» mu."

2»

.

‘1'

w

u m

war-—

December 29, 1967
Dr. Leon 0. Hankoff

Director, Department of Psychiatry

Queens Hospital Center
Queens General Hospital

82-68 l64th Street
Jamaica, New York
Dear Leon,
Your

visit to this

department was a stimulating one,

my associates and I have been encouraged to continue
our explorations in the development of a community based

and

satellite center. Please accept the

enclosed honorarium
and
token
is merely a
grossly unsatisfactory as a
fee for your services.

which

My

best wishes for the

coming

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc.

�November 1, l967

Dr. Leon ﬂ. hankoff

Director, Department of Psychiatry

Queens hospital Center
Queens General Hospital

l64th Street

82~68

Jamaica,

New

York

Dear Leon,
Thank you very much

for accepting our invitation to share

staff at the Mental Health Clinic, your impressions of
a psychiatric satellite clinic eleItion. As I mentioned, I am
interested in having observers of the Mental Health Clinic share
their experiences with my staff, as we struggle with the develoo»

with the

this Hospital. The meeting will take place
at Metropolitan hospital. 97th Street and Second Avenue, on
wednesday, hobemher 15, at l0:00 am. We will meet in the clinic
on the lSth floor. The meeting will be quite informal with a
ment of a program in

,

probable attendance of twelve to

fifteen staff

members.

Following your request, I have asked Dr. Robert Sharoff to
meet with you earlier at his office on hard 15A. This is one
of the psychonharmacology study units and is dedicated to the
study of new drugs in the treatment of addicts. He will share
with you his extensive experience in many treatment attempts
with this population. I am taking the liberty of enclosing a
copy of the report which has just appeared in the J.A.M.A. Which
describes our most recent experience.
would be pleased to tell you of.our more
studies that have been suspended
because of.a shortage of medicatieo - a shortage which I hope is
temporary for this work has been most exciting.

If time permits,

recent

I

work with naloxone «

Thank you

for your willingness to visit with us.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry'

Max

.Mszp

'

�</text>
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                    <text>May

2. 1968

Hr. Lee Hanna

Director of

News

HCBS—TV

5l8 West 57th St.

New

York. New York l00l9

Dear Mr. Hanna:
He

would

appreciate

a

print of film

“:nti~na¥§otic” as prepared
0 “CBS”

by Mr. Earl

labeled
Ubill and the staff
Ho. 24556.

0

We understand there will be a charge for this prid‘
and I am prepared to reimburse H085 as suggested in my
discussion with Mr. Earl Uboll's secretary, Miss Hockman.
He would be very grateful if this print could be made
available before May §, which would penoit us to use
in
a special lecture on May 10.

it

Thank you

for your assistance.
Sioceroly yours.
Fink, ”.0.
Professor of Psychiatry

Max

MF:kp

cc: Mr. Uboll

�</text>
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                    <text>May

2, 1968

Mr. Lee Hanna

Director of

News

HCBS-TV

518 West 57th St.
York, New York 10019

New

Dear Mr. Hanna:
wouid appreciate a print of fi1m No. 24556, 1abe1ed
"anti—narcotic" as prepared by Mr. Ear1 Ubi11 and the staff
He

of

NCBS~TV.

understand there wi11 be a charge for this prind:
and I am prepared to reimburse WCBS as suggested in my
discussion with Mr. Eari Ube11's secretary, Miss Heckman.
We

We

wou1d be very

gratefui

if this print

avai1ab1e before May 9,
a specia1 1ecture on May 10.
Thank you

which wou1d

cou1d be made
permit us to use

it

for your assistance.
Sincere1y yours,

'

Mszp
cc:

Mr. Ube11

Fink, M.D.
Professor of Psychiatry

Max

in

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Dr. udhondul EnquLoni. stuto Helplt‘l
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D01! Dr. Hume:
Our report on LSD has been accept-d for publication in the Archive: and I was ruqncntod to writ: an
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nncloa¢d 1: a capy’ﬁ?"€53€'331ﬁorIiI.
ainccroly yours.
ﬂax Fink. H.D.

Plofnnaor 0: Psychiatry

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Dear Dr. Emma:
Our report on 1.80 has been acccptod tor publication in the Archive. and I was ruquutod to writ. an
canon-1:1 for £53 mum Radical Aawctaﬂ.on Journal. .
1:

Encloood 1a a

my 0

or

.

uncoruy you”.

wmﬂF-n'nrv"

~an-vwm-awmwmvuw—wmy—u

.VW-nwmrm-rvamm—vw

rﬁyr.

”mmlww

ﬂux

rink. Inn.
of Paydxutry

manor

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                    <text>September 14. 1964

Dr. Grahal Harding
College for Advanced Technology
Gosta Garden. 4
Birmingham, England
Dear Dr. Harding:

la: on take this opportunity to thank you for your kindneaa
iatereat during IV reoeut viait to Bireinghaa. I have just
written to Jim, telling him of my thoughts regarding your affilia.
tion. I think it it most encouraging the: there are so many placaa
in England that are undertaking quantitative electroencephalographic
research. I believe that there are probably more such workers in
Please
and

your country than iawqur own, and am encouraging him to perhaps
arrange a meeting sometime in the near future of the workers from
both continents.

I am enclosing some of the recent uimeogrephed
earlier publications of our work that may interest you.

For the meantime,

reports

My

and

best regards.
Sincerely yours.
Max

Fink. H.

Director
HP/jb

Inc.

D.

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                    <text>September 14, 1964

Dr. Grahan.ﬂnrdtng'
Collegn for Advanced Technology
Goat. Garden. 4
Birmingham, England
Dear Dr. Harding:

Pleas: la: un-take this opportunity to thank you for your kindness
and intcraat during my rue-n: visit to Biruﬂnghsn. I have just
writCQn to Jim. telling him of my thoughts regarding your affilia—
tion. ‘I think it'iu most encouraging that there are so many places
in England that are undertdking quantitativa electroenccphalographtc
resaarch. I believe that there are probably more such workars in
your country than in our own, and am encauraging him to perhaps
arrange a meeting aometimn 1n the near future of thc workers from
both continents.

I am analosing éome of the recent mimeographad
earlier publications of our work that may interest you.

For tha maantimn,

reports

My

and

best regardsg’
Sincerely yours,
Max

Fink,

Director

rem/1b

Inc.

M. D.

�</text>
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                    <text>u- 'm“ n»...- w—
.A

1333-5183):

hbnnry 6th,

1'.

Yon”,

T0!

8128211.]

m”:

m Fink, NJ).

8W:

Departmental

1913

”.13.

Ming

I tarot that I

muting
Win}.
momma tn

M

cannot attend the
February 8th.
I had

many, to locturt 81:.
u .Vimunt': {lo-pita;
Manny
Yerk on nut-zone ammonia”.
on

gar/1.1

3:3

in

In

�</text>
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                    <text>February 17, 1971
A. Hargreaves, Ph.D.
The Langley Porter Neuropsychiatric
401 Parnassus Avenue

Dr.

Wm.

San Francisco,
Dear

California

Institute

94122

Bill,

Stanley, Rhea Dornbush, Jan Volavka, Richard Abrams and I have read
and discussed your report at length. It is an interesting suggestion,
that the memory and EEG effects may require hours to "mature". In one
group of patients we did try to assess memory changes at 3 hours postseizure but the study was incomplete, and we are unable to contribute
to the hypothesis from these data.
Our recent EEG data does not allow a test of the suggestion. We are
writing the protocol for a new study, however, and if we are able, will
include some serial EEG recordings to try to answer the question.
Thanks again

for the opportunity to read this report.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>PW“ ,WW‘

.,.,,..,“.,...__

.-...-.

..-.

,

«w-

'1'

.~

‘W’m'-w—-—w-v—Ww1w'vun\w-mrmn

"W

I

December 11, 1969

narick Press, Inc.

665 Middle Nook Road

Great Neck,

New

York

Gentlemen:

Enclosed are the corrected proofs of our announcement.
In addition to the small corrections indicated, it is our
impression that the title of the Association, the location
of the meeting and the date might be made up in a bolder type.
The comment "Pleast Post“ should be re—set in a less bold type.
In all of the reapects the text and tho stock sampled are

satisfactory.
We

will need

500

copies.
Sincerely yours,

Professor of Psychiatry
Mfzko

�</text>
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                    <text>rump-Fwy.

:wWWTm"

nnl'wv‘rz'rw‘umr

.

_

.

wwwrmv-mmmrw—survWat's; 31"!- --v Wmmuwm—mv‘

V

.i

April 13, 1977
Dr. Thalia Harmony
Habana, Cuba
Dear Dr. Harmony,
Than you

for your interesting reprints

regarding the citation in the

CHAN

volume.

and the question
I note from your papers

that E. Roy John has been one of your preceptors. In the CHAN
discussion, I was citing the many advances in this country in the
development of special computers for diagnosis (the work of Harner,
for example); the use of averaged evpked potentials for the identification
of brain damage (here the work of John is a fine example); and the
use of cross correlators (the work of John is still the best example).
In the latter reference I was also interested in the studies by Leonide
Goldstein. There are surely others but they do not come to mind
readily, although I recall similar interests by the school at the
UCLA Brain Research Institute (Adeyyand his co—workers).
.

i
'

is far

studies
reflected in your studies. We emphasize the application of the EEG
to the definition of drug effects-- a good example is the paper in
My

work

from the basic neurological

the CHAN and that of my former co-worker, T. Itil.
question regarding that study, please write again.

If

you have some

.Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>wrﬁm

-.v-~v

&lt;u.”yv-v"~vr~v‘

”Rm-unm‘p‘,w-ww-.. “mm"."wv. ,....—.—_,__.,._m-.~.~.«n ,.
——-

September 8, 1975

Stovnn R. Hurnad, M.D.
College of Modicino and Dentistry

of

Nov

Jersey

Rutgers Medical School, Dcpt. of Psychiatry
Univorlity ﬂhighta
Piocatsmuy. New Jersey 0885h
Dear Dr. Harnud,
We

in the

would be planned

Amnrican

EEG

may do your

rccommnnd you

for

mamborship

Society.

«would you

I

to

please Iond.mo a capy of your

CV

to that

record Justice.
Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

MF/mr

�</text>
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                    <text>August 5, 1983
Dr. Steven Harnad, Editor
Behavioral and Brain Sciences

Suite 240

20 Nassau

Street

Princeton, New Jersey 08540
Dear Dr. Harnad,
in reply to your

letter of July 27::

1. Changing substantive to substantial in paragraphs 2 and 3 of my comment on
Weiner's article does not change the sense of my discussion and the comment may

stand.

2. Squire and his associates have presented numerous reports on the effects of
bilateral and unilateral ECT on memory functions. I do not believe a reference is
needed, since Weiner has already given the important ones. But if you believe it
helpful, add:
Squire, L.R. and Slater, P.C. Electroconvulsive therapy and complaints of
memory dysfunction: A prospective three-year follow-up study. gr. J. Psychiat.
_l__lg_2_:

1-8, 1983.

3. The suggestions for changes in consent procedures which Weiner makes were
made by the APA Task Force. He is repeating what is already in the record,
perhaps with less attribution than is deserved. The suggestions in the consent were
published by the APA Task Force in 1978 and in my book, 1979. The APA book was
published in November, 1978.
4. Roueche, B. Annals of medicine: as empty as Eve. New Yorker 2Q: Sit-100, Sep.

9, 1974.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>m

13-. Harold L.

2. 1986

William

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908

9:.

'3 Elm Slim lab. Div.

Olive
Louis,

Attentim:
Dear

mm
Mn.

6'31m

Stigmyer'

311*:

Please adjust imoim

No. 377% and

mmhmit:

6‘5 x

7

prints mt included

9.5 x

7

print:

cm km on. sat

pﬂntsamfmmme
Wgatiw duplicated.

sas x

7

sat

Thank you.

Sirmmly yours,
Max Pixie, Md).

Professor of Psychiatry

�</text>
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                    <text>7483—01383
7

Health Raeearch Council of
Department of Health

Boon 1020
125 Worth
New

New

January 1974

York

Street

York, New York 10013
Re:

Richard Raenick, M.D.

Gentleman:

I am writing at the requaet of Dr. Richard Reanick in eupof
hie application for a career ecientiet award. I have
port
known Dr. Reenink eince hie reeidency training at Hillside Eoe«
pital in 1959-1961; and aince 1967. an a member of the Divieion
of Biological Paychiatry at the New York Medical College. In
January, 1973. on my recommendation, Dr. Reanick aeenned reeponeibility for the drug abuse reeearch program: as I left for
a new position at the State Univereity of New York at Stony Brook.
Dr. Reeniok has developed into an enthusiastic, imaginative,
investigator. Hie interest nae inetrunental in
maintaining adequate cane loads for our evaluation: of cyolaro~
cine. and in auetainins the etudiea of naltrexone under initially
and reeourcaful

difiicult conditions.

accepted the reaponeibilitiee of lead—
erehip with elacrity and an the demands of the reaearch program
increaeed. gave up hie private practice of clinical paychiatry
to devote full time to these reeeerch efforts.
He

Hie etudy programe in rapid detoxification from methadone
and the clinical pharmacology of cocaine are timely and logical

exteneiona of our present etudiee of opiate ahaee. I
to recommend him for the award he aeeko.

am

pleated

Sincerely youre,
Fink, H.D.
Profeeeor of Psychiatry

Max

MF/cie

�</text>
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                    <text>January 6,

19615

Dr. J. A. Harris
Department of Psychological Medicine
Newcastle-upon-Iyne General Hospital
England
Dear Dr.

Harris:

It was with great pleasure that I received your letter of January 2,
regarding positions at the Institute. To give you an idea of the extent
to which we have invested our energies in EEG analysis, I am enclosing
a copy of a report which was presented at a national meeting three months
ago. Since that time, we have added programs for power spectmn, plotting
analyses to give us a graphic representation, and solved a number of the
technical problems of EEG recording described in your letter.
As you

joined the
job.

my

know, Dr. Harry Netmamr, who was formerly
March and has done

staff of this Institute last

at Newcastle,

a commndable

Some general facts about the Institute are as follows. The Missouri
Institute of Psychiatry is the research and training center of the Division
of Mental Diseases of Missouri. It was established in October, 1962, with
laboratory and clinical facilities for research. At the present time, of
150 beds, we are utilizing 70 for research purposes. Laboratories are
established in pharmacology, psychology, and electmencephalog'aphy, as
well as a computer center for both statistical and EG analyses. There is
a specialized psychiatric research library as a component wt of the In-

stitute.

Animal

facilities are

now

being

built.

is a fully qualified threewyear psychiatric residency
the
training program at
Institute, and a special training program in clinical
being
established. Both in the research programs and in the
psycholog is
Institute is affiliated with the Departnent of Psychithe
training program,
School of Medicine.
of
Washington
University
atry
In addition, there

�Dr.

J.

A.

At

Harris

page

the present time, there are a

January 6, 1960

2

nmnber

of research program in progress.

These include Lithium as a therapy for .mia; the use of Yohimbine as a
precipitant of anxiety and the development of anti-anxiety agents; relation
of EEG patterns and organic factors in the treatment of therapy resistant
psychotics; computer analysis of the electmmoephalog‘am; the effects of
and the treatment of
drug withdrawal m behavior in the chronically

ill;

psychotics by nurse relatimship therapy.

Acoonmdations are available for rental or for sale within ten
minutes of the Institute. It is our custom to provide temporary acoonmodations at the institution for scientists appointed from overseas.

,

Appointments are made at salary levels connenswate with experience
with a minimum sheen being $12,000 per annum. In addition to research
experience, satisfactory cospletion of the DPM is weighed heavily in the
determination of salary. Satisfactory counpletion of the ECIMG examination
with either a temporary or pemanent certificate is prerequisite to appointment.
am enclosing a 1962 description of the Institute. I would appreciate
of
a copy
your mimlmn vita listing ctmonologically your educational
and professional experience. In addition, a small photograph and the names
of at least two referees to whom we may write would be most helpful.

I

Sincerely yours,
Max

Fink,

Director
MF:aw

anc-

P. 8.

My

best regards to Dr. Roth.

M.

D.

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                    <text>Jmuary 7,

1965

Weak
Jam
MW. m:
Thmkyoumymfortmseminstallmntofﬁn

m. J.

Smdoz

A.

Hmovw,

Salado:

Rania

Ned

mnt~in-aid, m behalf of tha means: prom of the
The
has been in

Psydxiatvic

Mam mm.

study

progress.

for a umber of mmﬂm and in matinuing quite satisfactorily.
Also,

thmkymforsandmgmﬁnphmboformmﬂl

initial supply arrived safely and we will be able
farmymkawiﬁxthissupply. Thank
mmwtmmauﬂias
youalso forms LSD—25.
Capsules . The

'

Sincerely yours,
Pink, NJ).
Exec. Dimetor

Mm:

�</text>
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                    <text>April 21.

Mr.

J.

A.

1965

Harris

Smdoz Pharmaceuticals
Hanover, Hm Jersey
Dear Mr. Harris:
Ha have

mmiﬁod the "quashed supply of semty—scvon

bottles of Helm-3.1 capsules,
arrived safely.

50

m.

100's.

The

carton

Hymaaiateindicshesthatlnpesﬁmteswﬂlmquim

madditiamlsupplyofl‘knmﬂcupsulaamdwewould

eatimtaﬂutifﬂuaddiﬁmal

aightom bottle oouldbe

Mavaihbhbyﬁnmdofdm,
satiafaatoxyandmthalpfnl.
ﬂunk you for your

miewouldbcquite

mmmtim.
Sincerely yours.
Pink, M. D.
Professor of Psydmiatry

Max

‘

�</text>
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                    <text>Septcuhcr 1‘. 1964

Er.

J.

A.

Harris

Sande: Ph:xmnceut1anla
Radical Department
Hanover, Raw Jcrocy

at. B‘rrio:

Dear

for your coppcration with Dr. Willitm Ltag‘l
LSD*25
for
for
his antmhl studias. It was due to an
Inquest
'ovarsight on my part that I bud not made the propar raquest be~
{are leuving for Europe.
Thank you vary much

is part of the prajaets supparted

by HIE ané the
manta!
of
of
Missouri
thu State
Division of
Discases
at this
institution.‘ Ybur coaporation £5.811p1y appraciatad.

This study

Sinnerely yours,

rm. 5. n.
m
Dirnctor
Hr/jb

cc:

Dr. R. Birehat

�</text>
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Mr.J.A.Hamis

7, 1955

,

W,MJm¢y
www.mm:

unsuppliesofWCapoumuﬂLSDhaveax-dved

MMWMfwmmPMm—mﬁm.
Imuldulmywtomnr.mfwhiagmimu
dwingﬁumﬁngminﬂcw‘lm.
safely.

8111:»me yum,

W M.

M. D.

Professor of Psychiatry

�</text>
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                    <text>June 17, 1965

John A. Harris, 14.8.
Mayo

Clinic

Rochester. Minnesota

Dear Dr. Hands:

First, let me thmk you for the samples of younwork which
sent to me. Both Mr. Shapiro and I have found
of
intemst, especially the prediction study which seems tothese
confirm
the validity of your model.
I regret that you have not been able to devote more time to
you have

‘

,

mix problem and I believe we need the explorations of
my mdels
if we are to have better EEG analytic metiwde.
I am taking the liberty of sending you a wpyof a report we
have recently owpleted. While the study
is pedestrian, it
provided

“the

Opportmity to

methods nemesary
My

test the

EEG,

for drug discriminati

.

mater,

and

statistical

.

best wishes in your studies.
Sincerely yours ,
Mex

Fink.

M. D.

.

Professor- of Psychiatry

enclosure

�</text>
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                  <elementText elementTextId="105923">
                    <text>. “a...“wwwx»

I"ua-~' . .«u “v. mw-vvvw-v-

»- v

vwmvr-r

w

y. .nmm.a._—~..V".—r*WWV~V§~‘FV.m——,*WLKAV , ‘vr.n.-Y'.-~,VJI=V

Wynn”... ._.. "a.

w ”p-

w.“ w:

,.-.«axf'lf:~9‘l‘lvv

July 22,

&lt;.-,,-,..

1970

.-

'a-rw

Ina-2v"

w‘mwwnww-r

“WI?

-

“xv-yrswr‘nvn

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of Medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

urn-t

mn-wmw:m~‘u4~rzrnnﬁwv

check as reimbursement

that the
Science.
in
published
You know

for expenses for

summary

much

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone fer clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

mﬁ-‘l—HHHYWH“'mzwr1aﬁs‘n‘uV.-

is our

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

My

7"mM'vvrnv'c

am

best regards for

a

pleasant

summer.

Sincerely yours,

'I'

wu'zm-‘w'

”ﬂ

r-vv,

Max

w

raw-mime»

‘j’

Mpzkt

ufn-T'vv

”rum

-

""',l“r!“1“!l

K‘Oim-ﬂ.

Fink,

M.D.

Professor of Psychiatry

enc.

.u

m...”

.-er‘:l‘b'w

�</text>
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..

“my—(”rm (y..—

.V‘n-v—‘~"

wuvwnnw-mv'm-n—;mvu"‘m--tm.

. I-r'u,‘

ww.’ ‘1 “W1”...-w-¢m_v_.__,,“w"; "—7,.” n— ‘1”.‘Fwn—n

July

1m,

www
_

22 , 1970

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

is our

You know

that the

check as reimbursement for expenses

the June 4 meeting on narcotic antagonists.
appreciate your participating.
published in §gienge,

summary

I very much

for

of the proceedings are to be

sure you heard that Endo (PuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility“,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, M.ﬁ.

Professor of 9sychiatry

MP

:kt

enc.

�</text>
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                    <text>Four"): my w. mr nava—mv-w-w—wa“

'

--

Wm v”&lt;' w. mow-aurrwvwwvr me-jy .FuuﬂWLmI—w—u—rmu,

w-‘m

~~

vw m-V‘I.V'.
.

w

ku Jr Wmprrmrw'i",

7-.

V

w

.

_

October 9, 1970
Dr. Louis Harris
Department of Pharmacoloqy
University of North Carolina School

of Medicine

Chapel

Hill, North Carolina

Dear Lou.
As we

discussed,

we now

have a supply of

M-SOSO

and would

like to undertake single dose trials in man to assay the duration
and degree of antagon
3m to injected heroin.
If these are
successful, we would assay chronic oral dosages (2-4 weeks) and
assess the degree of antagonism; and then develop a parenteral
formulation, hopefully of long duration.

abide by prevailing practice, we will need animal toxicity
file for an IND. Our letter to the FDA is enclosed. I
would value your opinion as to what is needed. Can you
out
the project? At what estimated cost. for we would like carry
to present
such an estimate to the New York State Narcotic Addiction Control
To

data to

Commission.

I look forward
My

to seeing

you in Puerto'Rico.

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
enc. Letter to

FDA

Science summary.

�</text>
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                    <text>April

12 , 1985

We
Word.»
Mayo minis
Ir.

ms

'1'.

Wm, Minncaota
marlin Harris:

My «sedan, Mr. Shapiro and I mull our discussions
inSmteFe nguﬂngyampattcmmoogﬁtimmdalawitha

dul of intnmt. his ham continuad to explore the more
31ml. froqmcy malytic modal, mixing rather Mavily

grunt

thu period analytic:

prom.

.

Hmhavayo‘mamdiespmgmmd?

an next few mths?
mm bamﬁt in getting-togaﬁw withinWmldtrmbamy

Ifw.mmldbophmdtoinv1toymtovinit3t.1miato

providn

am

3101mm. Ifthiais
are quite heavy mtil ark-Hay,

formepportmitytodims
om!

feasible,

pmsmt

Mthcnaftarmmtohawthelmuryofafwnmﬂmof

momma.
I look

forward

to hearing from you.
sinmmly yams,
Mat Fink,

M.

D.

Professor of Paychittxy

�</text>
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                    <text>February 26, 196k

Dr. T. A. Harris
Hebraska Psychiatric Institut¢
602 South ﬁdth Avenue
Omaha 5, Nabrlnka
Dear Dr.

aurris:

yaut ago, Dr. Garfiald raeomnondad you for appqtntuont in
our programs. In reviewing our retards, I cam; acrcss our
letter to you of March h, 1963, and I am taking the liberty
of enclosing a copy of our first annual report.

A

the information containad in aha report is of
intarest, I would be pleased to hear from you.
$1ncere1y yaurl,

If

any of

Max

Fink,

Diwaetor

HF/jb
BBQ

0

M.D.

�</text>
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                    <text>August 19, 1968

Mr. Gnom- R. Harrison

Immandlnmity
mam
Associatimotwioa
730WAW
mm»: 17. N. Y.
warm.

Harrism:

mum you for your

letter of August 15,

3.963.

conuibutioxm

"inbomviaﬂnuluymdwtimmm.
wile the establist date of the plan was listed as January 1
resolution. the Board at its subsequent mating,
in the original
reviscd that to males the data July, 1963.

53le yours,

Fink. M. D.
m
Exowtiva Director

�</text>
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                    <text>Hovauber

8th.

1972

Senator Harri-on Goldin.

1020 Grand Concoursa,

Bronx, 3.1.

thSl.

Dear Senator Goldin.

It was

a pleasure to talk to you this morning,
enclosing a suumgry of the available «Vienna:
for tha clinical use or the narcotic antagonists in
apiate dependunee. This report has been submitted to
the Marijuana Commission and will be published as
part of their report ta the Presidant next spring.
and

I

am

8hou1d_you wish additional information, we would
be pleased to meet vith you. The principal center
vhare this work has been done in the New York area
‘13 the Metropolitan Hospital Mbntal Health Center,
whats there are many patientu in different stages of

treatmant.

Sincerely yours,

Fink. M.D.
Professor of Psychiatry
max

MF/id
Eng.

�</text>
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                    <text>August 25. 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Dr. Harrison:
Our initial trials with GP 41,299 have progressed well.
In 15 trisls in nor-a1 volunteers, we have used dosages of
25 to 200 mg. The observation period of EEG and behavior
has been 1 1/2 hours. we have also obtained the subject's
reports of the succeeding lé—Zh hours.
and

for

day.

behavioral effects of sedation, drowsiness
100 33. These symptoms persist
hours. the subjects reporting sleeping late the next

we have observed

lsssitude at dosages over

many

The EEG changes

are defined as increased theta and some
and a decrease in amplitudes.

delta; reduced beta activity;

These preliminary data are insufficient to classify 6? 41,299
but do provide the basis for the second phase study as outlined
in our protocol. Before undertaking this study. however, I an
anxious to check s few records at a longer time period (4 hours).
As soon as these trials are completed, I will send you a revised
part 2 of the protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Hrzkp

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                    <text>v‘

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.

_

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wwwt

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October 8, 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals

Ardsley,

New

York

Dear Wilma,

Enclosed is our interim report and revised protocol in
our studies of GP-41299. Pages 1-8 are the same as the copies
which you have.
I have revised the clinical trial sections, following
your suggestions and after discussing the possibilities with
We do have a number of patients who have been
my associaties.
maintained on either chlordiazepoxide or doxepin for many
months, and also some schizoPhrenics who have been maintained
on phenothiazines. These patients can be placed on placebo.
In the event that symptoms recur, we will be able to begin with
GP-41299. We will have to determine the dosage first and if
an effective range is observed, I would then plan to treat
alternate patients with chlordiazepoxide or GP-41299.

Concurrently, I plan to select a few patients admitted
for severe anxiety or schizophrenia to our in—patient beds and
begin Open clinical trial. In these the possibility that they
are resistant will remain.
laboratory data will be insured in the in—patients
do our best in the out-patients. You are aware
that it is often difficult to obtain the cooperation of out—
patients for laboratory studies.
and we

The

will

Part two of the EEG trial (GP vs. placebo) will begin
within the next few weeks. The clinical studies can begin
early in November and for this I request a supply of 25 mg
capsules of GP-41299. If available, 1000. It would be helpful
to have 200 additional placebo capsules.
nr' Hert;2ou
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Dr. Harrison

~2-

October 8, 1969

WWm—

Ame.

While I would like to suggest that equivalent capsules
of chlordiazepoxide each containing 25 mg, I am not sure that
this is the best strategy. If it turns out that a clinical
effective dosage of GP 41299 is much higher than 150 mg per day,
then a comparison with 25 mg chlordiazepoxide would have a
limitation. Either the capsules could be made up now or we
might wait until we have some data to permit a better judgment.

If this preliminary protocol is satisfactory,

prepare a supplementary budget
My

request.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszp

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3-.

.

Alzv‘.-_

December 15, 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Dr. Harrison:

Since

we

will have font patients

on GP-41299 my nurses
active compound and placebo.

request an additional supply of the
attached labels indicate on: present formulations and I
would appreciate 10 x 50 of each.
The

Sincerely yours,
3"!” Fink .

E":

.U.

Professor of Psychiatry

MF:kp

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      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
