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                    <text>7483—03783
22

January 1974

Joli Yarvura-Tobias
North Nassau Mental Health Cancer
1691 Northern Boulavard
Manhassot, New York 11030
Dr.

Dear Dr. Yarvura~Tobiasz

I would like to propose a symposium at tho forthcoming
World Congress of Biological Psychiatry on the subject of
Quantitativa Elaccroanccphalography
Psychophsrmacology.

I

would proposa to

intita participants

who

and

sra contriﬁuting to

our nndarstanding of the offsets of biological therapies (drugs
and induced convulsions) on brain function in man, using conputar analytic methods for tho naasnrnmant of CNS changes. ﬁnch
progress has been made in tho analysis of testing 836. focusaing
on froquancy and anplituda changas; on potentials avokad by san~

sory stimuli

of

CARP);

and by

anticipatory sat (CHV). Tho number
and I would suggest sons of

potential contributors is largo

the following ha invited:
M.

Saito

Osaka, Japan

J. Roubicak

Basel, Switzerland

D. Rosadini

Genoa,

T. 1:11

Istanbul, Turkey,

H. Mstousck

G8tsbor3, Swsdcn
Darmstadt, Germany

G. Dolca

L. Goldstain
C. Shagasa

J. Volsvka

Italy
and New York City

Jersey
Philadalphia, Pennsylvania
Rutgers,

Raw

-1-

York

Haw

City.

�Dr.

J. iggvurnvrobion

‘

22 January 1974

~2-

symposiua o! throo hours would allow the actcndaon to obtain an overview of tho progress in this field. which has been
grant during tho past few years, particularly in defining drug
A

affaots. nonnatioa bioavailability of psyohoactivc drugs.
defining the lototalixcd affect: of induced convulsions.

and

I trust this symposium could be iniéndad in tho program.
Should it b. tangible. I would proposo to call on Professors

Roubicek and 1:11 to

the ncaaion.

that. tho responsibility for organising
Sincerely yours.
Fink. M.D.
Professor of Ptychiotry

Max

HF/ois

cc: T. 1:11. H.D.

J. Roubiook,

M.D.
C. Shannon, H.D.

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                    <text>Vm‘m.wvmr

W imam-qty“ .u .w”
1‘

..

_T...,.v.,..‘...m.n.,‘,—»,

,‘Tmr.

-.

u-

t,_..

47...",

._\

.,

k

.w

v.7 .1,

.

w. ,,.

_

_

&gt;

-.

.0

"n.

-.

Irv&lt;=lm

,,
mun—w

w,

v
-

___.~..—,...—w-

May

a,

1968

Dr. David N. Greubcr't
3 Sl'xelter Rook Road
Manhasset, Long Island 11030
Dear Dr. Gmubert:

It was a pleasure talking to you on Sunday. I an pleased
to enclose a tearsheet of an article on fluphenaaim that my
associates and I have recently published, as well as a copy of
the swam-11y of the proceedings of a recent meeting held at
Sitges , Spain. In addition, copies of articles by Blachly
and Kurland are enclosed.

Fluphenazine enanthate is available as a oonmemial
5 cc ampules of 25 mg/cc.

preparation in

I

study.

am

also enclosing a

copy

of the protocol of our ongoing

In the event you would like to undertake such a study, I
to assist you and will contact the representative

would be glad

of Squibb.
My

best mgaxds.
Sincerely yours ,
Max Firﬂt, M.D.

Professor of Psychiatry

MP:kp

cc: Er. Marital

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                    <text>February

2,

1967

Dr. Gerda Gray
Pan Merican Health Organization
525 'IWenw—Third

Street,

N.W.

Washington, D.C. 20037
Dear Dr. Gray:

RB:

FS-556/E-67

for reconmending Dr. Fritz Gnirss. We would be
pleased to have him visit this mspital.
In trying to provide for his interest, I would suggest that
he prepare to visit us on a Friday and a Monday. Friday he would
have an opportunity to attend the Psychosomatic Saxdnar and on
Monday the Multidisciplinary Psychosomatic Obstetric - Gynecology
Clinic. One of the principal interests of the group has been the
Thank you

post-gastrectcmy syndrome and sane studies on the adnﬁnistration

of

LSD.

is no study program on cardiovascular diseases in
progress at this time.
.

There

that Dr. Gnirss write directly to Dr. Helen
Kaplan at Metropolitan Hospital, 1901 First Avenue , New York,
New York 10028, to make the specific arrangements for his visit.
I

would suggest

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MPﬂcp

I

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                    <text>link

15, 1987

Mr. Keith A. Greathouse
Sandoz Pharmaceuticals

Route 10
East Hanover, New Jersey 07936
Dear Mr. Greathouse,
i am not aware of. a pharmaco-EEG bioequivaience study for thioridezine.

it is possible that Professor itil of the New York Medical College in Valhalla
carried out such a study. Our own studies have been dedicated to a range of other
psychoactive substances, and i enclose recent summaries of our experience.

Peter lrwin was a leader in these projects in my laboratory. He joined the
Sande: professional staff about five years ago and is in your East Hanover facility.
Should you went direct information on our experience, i am confident that he is
able to answer your questions with as much security as lcould.
These studies were done with single channel EEG processing. in the past
year, we set up two EEG laboratories with multi-ieed EEG recording systems with
simultaneous processing of It to 16 channels of EEG in real time.
Thank you for your inquiry.

Sincerely yours,

Max Fink, Md).

Professor of Psychiatry

cc: Peter lrwin

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of cyciazocine treatment. In addition, I am taking the iiberty
of enclosing a preprint of another,report which describes the
ganerai phi osophy bf antaQOhiSts in the treatment of narcotic
addiction somewhat more fully, titheugh it is baseﬁ on the same
data.
Cyclazhcine is an experimehtai compound and is not available
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‘cyciazocine has nﬁt bash approved by the Food ané Drug hdministrao
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Dear Ernie,
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Mrs.
Green to me. 'As you can tell
Thank you for referring
from the heading of_this stationery; I left St. Louis in June 1966
and hava been most active in the study programsiin New-York. I
,hava established a laboratory for EEG and human psychopharmacoiogy.
Our interest'is in the affects of psychotropic drugs 0n behavior
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                    <text>0%
December

l3.

1967

Mrs. Eva Green
528

New

hehartin Street

Westminster, British Columbia

Canada
Dear

hrs. Green:

Enclosed is a preprint of a report which has recently
appeared in the QJAJLA. and which describes the present status

of cyclazocine treatment. In addition, I am taking the liberty
of enclosing a preprint of another report which describes the
general philosOphy of antagonists in the treatment of narcotic
somewhat more fully, although it is based on the same
addiction
ate.
Cyclazocine is an experimental compound and is not available
except in research centers. It is given both orally and parenterally.
The dosages are indicated in the report. At the present time
cyclazocine has not been approved by the Food and Drug Administra~
tion of the United States.

that responsible medical offices are interested
additional
uses of this compound please ask them
in exploring the
to write to me.
In the event

Sincerely yours,
Max

Fink, H.U.

Professor of Psychiatry

Mszp
cc:

Dr. Ernest Taves
12 Hubbard Park
Cambridge, Massachusetts 02l38

Dear Ernie,

for referring Mrs. Green to me. As you can tell
from the heading of this stationery, I left St. Louis in June l966
and have been most active in the study programsiin New York. I
have established a laboratory for EEG and human psychopharmacology.
Our interest is in the effects of psychotropic drugs on behavior
and the work with narcotic addicts is but one facet of the broad
Thank you

Spectrum of treatment of the mentally.

�</text>
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V

l..

,

.... p,“ mew—WT

~

V,

_.

,

V."

a

.,. m. .... .,

l4, i969

Dr. Jack Pefer Green
Chairman, Departmenf of Pharmacology
Mi. Sinai School of Medicine

New

York,

New

York

Dear Dr. Green:
Bofh Dr. Shapiro and

very much enjoyed our meeting
Perhaps There will be programs of common inferesf
hope fhaf we can work fogefher when necessary.
i

wifh you.
and

i

am enclosing some of The most recent reprinis from fhis
iaborafory. if fhe problem of anficholinergic drugs is of
i

parflcular inferesf, may recommend Volume 28 of
(in Bluuln Ruecvwh, Antichou'nugic iiawanogem,
i

Pnognebb
which i

edifed wifh Dr. Bradley. This volume contains addlfional
reporfs espetcaiiy focussed on this sfarfiing group of
hailuclnogens.
i

will be pleased

a? your convenience.

To show you Through our

iaboraforles

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlalry

MF:kp

,g or

�</text>
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                  <elementText elementTextId="102110">
                    <text>March 23, '1967

Messrs.

M.

Green and B. Finley

Experimnts Unlimited
9149

New

West End Avenue
York, New York 10025

Dear Messrs. Green and Finley:
Your

letter of March

2

was

sent to

me

for reply.

The

Department of Psychian‘y of the New York Medical College
has no study program at the present time for which
volunteers are needed. However, study program in the
use of new cmpounds are now being launched and volunteers

willbeneededattheendoftheyear.
The

specific nature of the age of the volunteers will

love to be determined by the studies themselves , although
the usual projects require young adults between 22 and no
years of age who are not taking medications of any kind,

norhavedeaasoforperiodsuptoonenonth.

The study programs will be within the Departnent of
Psychiatry and the responsible would be myself.
When you have developed this interesting service, I
would appreciate your continuing to keep me informed of the
means by which we can utilize such services.

Sincerely yours ,

W. Fink,

MOD.

Professor of Psychiatry

1%?qu

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                    <text>October 21.,

19634

Dr. Martin Green
Lakevillc Mcdical Center
2035

Iakeville

New Hyde

Park,

Road

New

York

Dear Martin:
Enclosed are two copies of the Hysteria paper
have had mtyped. It is, I believe, a better paper
than when first mitten. I have the following spegiﬂcﬂkh
'Ihe intmdmtion carries a
coumnts.
of
double simltamoua stimﬂatim which will be clear only
to those knowledgeable in the field.‘ I wonder if we could

which

I

mm

mdtpazWZmd3andmﬂmintmducticnveryahm
(paragraph 1 and u only)? In

hatcriala and’Methods, weaver,

mt discuss the Meth in sufficient dam depending
on the ability of the reader to find references. I would
suggest thattheﬂatarials mdherthod portionbemdcto
includethekindof desmdptimweincludedinmneofme
earlier reports. This mad also pmvide reasons for (12-Ii

we

do

mm

leting the foot~nctc on Page which is always m
'davim. In the Rcsults the best sunnarics of the paper are
written first. While this is an excellent tactic for pmsentingfrunaplatfom, Iwmderifitis thebest fcra
published report? I would suggest that the swunary states

mntsmﬂgeﬂbeinscrtcdlatermhthepapenpmfm
ably at the beginning of the discussion.
None

_

of

an;

mpiea have a

list of the

references

andIcminsertthemfnxnmymmr-yifyoudm'thavethm
madilyavailable.

‘

Implamingtobeinﬂewl'crkthefimtweek
Would you
pickmmning,
andpidcaplayscthat
we
of Decanter and hope to 121111ng withm.

mummm,

can go out together?
My

best regards tc'

all.
Sincerely yours,

was.

Elf/18

Naxfink,
,

111mm

Md).

�</text>
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                    <text>June 11, 1966

Dr. Hattie Green

2035 Lakeville Road

New Hyde

Park,

New

York

Dear Martin:

Enclosed are two copies of the hysteria paper, end the earlier
drafts which were in my files. In general. I find this draft
quite readable and believe if we make the necessary corrections
in English and style and add the references and retype it, that
it can probably go out.

In

my

original notes, I

was concerned about our

justification

for our diegnoeis of schizophrenia in Case 3. I have. therefore. tried to recall what he was like and have added two
sentence: on page 18, beginning with “Psychiatric examinations
disclosed..." and ending with "...nooda were noted". If you
have the original records. pleese rewrite this section, or at
least edit it carefully to prevent me from confabulating end
distorting end manifesting e concreteness, which may be the helleark of my present age.
Plans for the trip ere finally crystallized. We have given up
on the possibility of going under reduced rates and like sheep,
are accepting our late on a twenty-one day excursion. Martha
and the children will be in Greet Heck beginning about Jul; 25,
end I hope to arrive about August 1. Our trip begins August 5.
I look forward to spending some time with you then.
My

best regards to Alice.
Sincerely years,
He: Fink,

Director

HF/jb
Bee.

M. D.

�</text>
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                    <text>u—wr—,»,nwv

wwmm

—-m—n-um.¢~"u,- w-——mv.,. m“

mu—w

_

.qu

mum—.mmmm-n—w-‘.w". “yummwv.,, 7—4.?”

Octobcr 21 , 196R
Martin Green

I‘m.

Lakevills Medical Center
2035 Lakevills Road

New Hyde

Park,

New

WW:

York

Biolosed am two copies of the Hysteria paper
I have had mtypsd. It is, I believe, a better paper
than when first written. I have the following specific

which

W
mtpmgmmZmdBandmthoinmductimwryshom
form of
comma. The intmductim carries a
whim
11
be
w
double simltmeous stimhtion
clear only
to those hwwledgoable in the field. I wmder if we could

1 and only)? In ﬂatsz‘isls and Hethods,
(mph
do not discuss the Method in sufficient degree depending

ham-rover,

‘

*4

we

the ability of the reader to find mfmoea. I would
suggest that the Materials and Mom portim be mods to
include the kind of descriptim we included in sans of the
oarlier reports. This would also provide masons for de~
leting tho foot-note on Page I; which is always an awkwazd
devise. IntheRssultsthebost smiosofthepapersre
written first. While this is an excellent tactic for presenting from a platfom, I waser if it is the best for a
published report? I would august that the sunny statommts on Page be inssrted later on in the paper, prefer»
ably at the beginning of the discussion.
on

1%

None

of

my

copies have a

list

of the refomnms

andlcminsertﬂmfmnmymamryifyoudm’thave

readily available.
‘

Iamplamﬁng‘bobeianYoﬁcthefirstwesk

ofmowbormdlnpetobringmwithm.
and pick
pick an evening,

othorthdeay.

momgoou’ctogother?
My

best regards to

all.
Sincerely yours,

«as.

Mlle

them

Max

Fink,

Director

M.D.

Wouldyou

a play so that

�</text>
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                    <text>Esmer-

8, 198“

Dr. ﬂax-tin Green

Neville

Medical Center

2035 Lakeville Road
Nan Hyde Park, New York

Dearﬂartin:

ImlymchenjoyedbothtMVisit toyoxmhane
Youmsthm
I was iwraased by

onHamkahandmmgettogetMrmPriday.
how

m

mfidmm in handling the

your children, especially AMy's

«my.

Emlosedisyowcarbmmdaxemxcopyofyam
A man in his position is
amazingly sensitive to ﬂights and
I believe he would be mmpapcr.

Iwouldurgayoutosendthecarbmtom. Bender.

if the publication were to

appear
witmuthishavinghadacopymshisdnskintheevmthe
wish

uality that

may

Good

to criticize scathing in

ludc and

my

best wishes.
Sincerely yours,
Max

Pink,

Dimctar

131'

313

enclosures

M.D.

it.

�</text>
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                    <text>/
Wﬁw

Min

Dr.
A. Green
10 Brinrclifr Brita

Pm

Wuhington,

Nam

10!!

Bur mm.

Institute of Paulina-y is an mm training
ventral: center. In View of your mom aquarium in
uni-clog, us would be plemd ta hm you Micipate in a
seminar during the month of Janina. If you can specify the
date thntyouwbe available in St. Innis. w mambo planned
to hm you not with our amt. Except. for January 13th and 16th,
and January 211.26, I should bu annual: on any other day that. month.
and

The Missouri.

My

but personal

roam-dc,

Simorely yours,
MISSOURI INSTITUTE OF PSYCHIATRY

m Fink, H. D.

Wu“:

Plates address:

Director

mopendtm to:

Shea Arcana

Street, St. Lani: 39,

Mo.

�</text>
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W

‘

Dr. Martin A. Green

Lakeville

2035

Park,
Dear Martin:

New Hyde

Road

New Ycrk

enclosed is part payment for tho
on your
in conjunctian with the disousaians expenses
that we held
ragarding tha study programs I brought from Hillsida.
I would appreciate ycur sending me the airline ticket
stub, if you have it available. as that would indicate
that I am a better administrator than I really am.

trip

The

My

best regards.

Sincanaly yours,

Fink,
Director

Max

Hrsaw

an“:

H. D.

�</text>
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                    <text>Dr. Martin A. Green

Lakeville
Park,

2035

New Hyde

Road

New York

Dear Martin:
Thu enclosed is part paymant for the
an your
trip in conjunctien with the discussions expenses
that we held

ragarding the study programs I brought from Hillside.
I would appreciate your sanding me the airline ticket

stub.

if

My

it available. as that would indicate
better administrator than I really am.

you have

that I an

a

best regards.
Sincerely yours.
Fink.
Director

Max

Mfzaw
Giles

M. D.

�</text>
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                    <text>derulty

15, 1955

Dr. Martin A. Greta. H.D.

Lakavillo undlcal Canter
Lakavillc and ﬂew Hyde Park Road:
ﬂaw Hydc Park
Long Island. luv York

Boar Hattlné

'

-

ﬂy buddy. Turan 1:11, wuuld 11kt to participate in IOII of tha
Idvuntagos of the Eastern EEG Socloty. including invitations to thc
ski tastings nnd pcthaps tho spacial rudncad fnxaa on plane trip:
to Eurapo ch11 auunnr. a; has asked II no rtaolnnnd him to the
Eastctn 386 Society. and uh. talc: regatta that he be nponnotud by
two of us. Would you be willing to write a letter to Dr. Hilton
T¢rlau. Socrutnry—rruaauror. EAIEG. 80-02 lav antenna Road. Raw
Gard»: 15. lay York. on Dr. Icll‘n banal” For your information.
a copy of his curriculum vita. 1: enclonod.

I expcct to be in ﬂaw York
Bast rcsards to All.

this wotkrcnd,

and

will

e111 you.

Sincerely yours.

HF:jn

HI! Fink, H.D.
Profoasor of Psychiatry

�</text>
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                    <text>August 23, 1965

Dr. Martin A. Groom
weaving Medical Cmter

Lakevilh

New Hyde

Road and

Park,

Now

[him Turnpike

York

Doarﬂartin:

Inﬁnhecticdaysofﬁwpaﬂfwmekmwewemnot

able to sit down md discuss the propoaod paper on EEG changes
in olootmshook. I have received Bob Kahn's commuts and they
are melooed.

I

original paper in the Hillside Journal
augmnts that
report and cm be
supplementary to it. Rather than my
modifying the introdmtion and the discussion to reflect the
fact that the inherent capacity for mmophysiological change
have reviewed your

Medal pmented hem
made

md believe that the

my be a determinmt of these differences, perhms you should

mnkethechmgos. Wouldymdoso?

to 1mm you for the pleasant weekend, and for your
wt
during
support
our ﬁfﬂcult days. me trip back to St. Innis
I

was moverrtful although
New

York.

owned and":
it New
York

I plm to have

longer than the trip to
next Sammy for London

mifIhaveadxmoe, Iwilloallyoumf‘riday.
Best regards

to everyme.
Sincerely yours ,
Max

Pink, NJ).

Professor of Psychiatry

MFﬂcp

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                    <text>Febnmy

224.

1965

MHydePsrk,NewYork

unrelia,ﬂsxtinmdkrdy.
Jonathan,

mwlmdelighted thathymybeeble

Asymemtellfrthenclc'Jsed
toesmmymmmtrip.
letter, I have requested the necessary transportation mud

WW
timfom,1wille¢mdtheeemmym.

formmeportimsofourfcrthcomimtripwhich
As soon as Ihsve the maeessry vise applies-

are almost “fixed."

Mportimofthetripfrmmtmbul,

Athens,

deoeeis

hftmenbecwelmmtsmastoﬂmnmbevofdeystbet
As
we will
this is "business"
in

Ietmbul.
e
spend
ymlsm,
portion for m as I as swims to establish a collaborative study
with the University. I anticipate that Turen will be in
prom
Istanbul at that time, waddle we may be busy professionally,

Immﬁident-ﬂmthismwindmpemxammdtheboys.
Ibeiieveyoushmldclnekmdmwxgeforhxdy'e passport

mmekesmﬂaetmmmmcesssryveocimtimfm‘mn-

paxdleelmdwithinﬁnpesttwomdm~helfyemeoﬂmtit

willhevslidstﬁneendofAugustmeeemettomtumto
ﬁxieemmtry
For the Rumian visa he

will need ﬁnes photogephe. It

has been suggested that we have additional photographs available
in case we mquim stopovers at other Bestem countries and for

myspecislmdeinﬂaeSouietlhﬁm. Implemingtoteke
make
four edditimel photographs and perhaps you should
copies at this time.

sign:

mm

mummaitimslmgewhimisposeme.
mtect with Professor Jus in Warsaw and asked me on
mmmrlwmldbewﬂlingtomtwiﬁmmmemdmin

has been in

ordertoesteblishsstudy promwithhismiveraityeswell.
Iexpectthst Mauser JuswillbeinWeshington next month. If

”.mmtﬂpmmmymtbemoessm.

Ifmt,wemsy

tmetwedeytriptonintMtportimNosmw-Ietmbul.

�Dr.

mm A.

m

Fobmy 2a,

~2~

1963

Idohapethiaitimmyplmesyou.

PartsofitmdictahedbyWixms“msuohmtln

pordminﬂasmmdlntmbul. ammmaam-mamp
overinPazisfox-atlomtmdnyaoﬁuthcomldmndﬂn

bmmtmdﬁnstmauctm.
Watmdxmﬁmtday.
ﬂy

Wiﬁamdy,mpmbab1ywill

best regards.
simmwaly yams,

Max

PM,

14.9.

meesaor of Payduiauy

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                    <text>«4

.

m, .\ w—Ww..." y.
V

w.»

,

-w ...V.... mw—_.‘._,.,.-V.w."-mr_ ‘.V—_..w._.——_-,~_. .

-V...“

...._..

.WV

v.._. - W- ..

.___.

w, "w

.

i.

.V

__.

Vr._...__ ,

WNW-.. _

Fwy-mp‘

r

\

-.

rpmwn—ww—w-m

January
rum-1m

12 , 1967

Dr. Martin A. Green
2035 Lakeville Road
New Hyde Park, New York

Dear Martin,

Fortoomanyyears Ihavebeenawandervogelmdso,
letter you sent me. What was uniﬁed, however,
is that for a time, the wandervogel enjoys his trips and
so gets a gratification which is not spelled out. I am
afraid in today's climate it will continue.
enjoyed the

you.

Incidentally, enclosed is an article which my interest
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

...

.n.

�</text>
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                    <text>Jamary l2 ,

1967

Dr. Martin A. Green

2035 Lakeville Road
Park, Ned York

New Hyde

Dear Martin,

FortoomnyyearsIravebeenewandewogelandso,
enjoyed the letter you sent me. What was omitted, however,
enjoys his trips and
is that for a time, the wandervogel
so gets a gratification which is not spelled out. I am
afraid in today's climate
ym.

it will continue.

Incidentally, enclosed is an article which

'

may

interest

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>7383~562SB

March
'rr‘

.
3..

”mgr-“w“

5th,

1973

Miurice R. argon. M.D.,
151 East 83ré 8t..
Rev York. N.Y. 10028.
Dear usury,

;
E

%

E

3

It was indaad a pleasura to hear tram you. Aline aha
Hurtin Joined my tunily tkiing 1n Vila. Eb had a fine tins.
Evan Alice got on skin, ana considering her phobic snxioty
dbout any harm that may cann to hay anklea, her willingnest
to try was nymbclic either of a raduction in fear. or In
assumption that her dancing was last important now than 1t
had bean than: unny yearn.
At

E

;
g
‘

g
%

tbs

pwﬁlemt time

SUNY

at stony

Brook does not hava

both be appointed.

It was sped hearing
W but regard- .

a":

-v.'r,

gnu

"v7.

from you.

‘WV'M‘H‘

sinceraly ynurs,

m7“

wr-ag-rv

-

«syn-«m,»

3-

Nb: Fink, M.D.

7w-

Protester of Psyuhiatry

:(—:

~

I'mvy"'&lt;:

6
$’Y5"-J/'

'fxu

ﬁ,‘
w
:-

nvrm-rqv—

«.u

"mm-v;

'l-rmn‘rr-Wn'

r

mwrmﬂ"

1t-

hospital and is dapundent an the elinieul faculties of the
v.1. ﬁosyital, meadowbrook, Long Islnnd Jewish Hoayitul, und
Central 1:11p. I do not think the opportunity for a part~
tint positicn at the univarsity is too good. my expectution
is that within a few years, when the clinical center at the
univursity is finally completed, clinical fund; will be
tvnildbla and a faculty, both partutimm and fu11~t1nm will

awn

Ml/iﬁ

�</text>
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                    <text>"7w

".mevu'

7388—80983

.mm-wvr—

11 December 1973
«rm

—

»F-.

v.

"ILVU

'

I

Mr. Robert Cuddihy

Sandoz~Wander,

East Hanover,

Inc.

New

Jersey 07936

Dear Mr. Ouddihy:
About two years ago I presented some data at the Drug
Information Association meeting. I was assured that it would
be published in a forthcoming issue of the BIA Journal. When
I had not heard from Frank Liaka, I write to him and in his
answer of June 22 he indicated that I would hear from you.
The information presented at that time has already been
published elsewhere and I wish to withdraw that report.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

�</text>
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                    <text>L
g
g

F

E
5

October 30, 196“

Milton Gmenbla’ct, Md).
Superintendant, Boston State Hospital
591 Hortm

Street

Boston 24, Massadzusetts

2

_-.

..

-.-

.—..~.

aww-w-mmu...”

.

Dear Milt:

In so

It was a pleasm
be

talking to

you

in Washington.

it my helpful to you, I am sending you
of my oﬁrx‘iculum vitae. Also, I am enclosing

far as

a copy
a
copy of the review that I recently gave at C.I.N.P.,
with the Immiedge that many of the thoughts were 133-ported by you

many

My

best

years ago. However,

a clear pictwe of the major focus of

my

it will give you

present interests.

mamlmgards.
Sincerely yours ,
1%}:

Pink,

Director

Inf/ls

e ncloswes

M.D.

�</text>
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                    <text>,

.

w ......
.. ..7..wywrm.ra—__....,—,\.w.-.‘;(._.q___.wv_

w‘v—y...-\.._

“w..." ,v .v.

“ﬂ. “ ..

-,‘,,..V_.r_v_.__..._,_.n~V—-v

_. -. WV- ‘r-

w.

MW."

‘

h. ....."._..

,

n“

_.,,

my," ..

-nm—

www.m-p

‘Iurw'H-I'WW-

wv&gt;1—-"r.‘w

7BSB~77583

'4ruwwn’1

'y"wﬂ4"5"'-WJW‘A'&gt;'

16 ﬁavuﬂbor 1973
"Harv

I
I"

r
3“"

,

'.I""T‘r'

W

vuau rum.

3.».

Alan Corporation
950 Past M111 Enid

Pale Alto. Ctlifornin

9&amp;304

Dear Virgil:

llplln to

visit my

son, a graduate laudtnt in the antrt~
at ananford University. on Monday. Dgcudber 3.
I will Eek. tha libatty of calling your office in the morning
in the hope that it would by possible for an to 3.: coauther
for a chat sous tins ﬁurins Eh. day.

man: of Ecology

‘I‘.

My

‘mg-u.

has: rugsxaa,
Stnanrely yaurs.
Max

Fink.

“.9.

Profcssor of Paychiacry

MF/cin

-m

i

am,

v

.._.

,

-77

�</text>
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                    <text>7383—7663!

17 Octobar 1973

Dr. G. Dole.

c/o Laoaida Goldstcin, 3¢.D.
nutsuru undieal Sahaol
University Haishts
Piacntnuay, ﬂaw Jursay 08855
baa: Dr. Dulce:

I II dalishtaﬂ that you will b: in tha States during tho month
of Novanbat. I will b. :way until Rovaabnr 10. but I will be glad
to have you visit any day thereafter. P1513: call no at (516)-64b2447 after Huvunber 10 and v: can Irrtage a suitable tins.
my
v

best regarda.
Sincurcly yours.

'
"

:H

W

w"

Fiﬁ. HID.
m
Professor of Psychiutry

”my—w

wWWWNWI'I-p‘h

ﬁllet!

�</text>
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                    <text>Milton Grocnhlatt, M.D.
Department of Psychiatry &amp; Behavioral Sciences
U. California, Los Angeles
Los Angeles, California 9002h
Deni-

Milt ,

It

an
;. following on behalf of the
preposed. advancement of "
Professor in Residence V.
My acquaintance 175th Dr. ?..
q'
his
publications and in
our activities in the American Collcge of Neuropsychopharmacology.
'

.

.

Dr. May's outstanding contribution has been a study of the
treatment of the severe mentally ill by drugs, milieu and ECT. This
work clearly demonstrated the efficacy and safety of drug therapy in
those patients. Surprisingly. the efficacy of ECT was also demonstrated
and in this regard, the reports are among the more important in the
literature. For this contribution, he was awarded the Paul Book Award
of the American Psychopathologicnl Association.
His breadth of intsreat is seen in his writings in such
topics as statistics, prediction of treatncnt response, paychologicll
teats, rehabilitation, mantel health care delivery and nursing. He
has also written on natural history topics, particularly in the habits
of woodpeckers.

In addition to his teaching of residents in training and

modical students, Dr. Mhy is an authority on the treatment of
schizophrenia and has preparcd cassette tapes for post graduate education
on

this topic.

He

has served as President of the Amcrican College of
serving that socioty wall for a number of years.

Rouropnychophnrmacology,

Dr. May in well known in this nation and overseas for his
contributions, erudition, and divcrsc inteiesta. It is a pleasure to
recommend him highly for promotion to Professor in Residence V.

Sincerely yours,
Fink, M.D.
Pfofccsor of Psychiatry
Max

�</text>
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                    <text>Manet 20, 1963
Mr. H. A.

m

Wm WWW
Grants and Beware):
Conn-acts
Office of Spam Science-a
National Wade: and Space ministration
25, D. c.
March

mm
mm m:

Thankyou varymch

Fm

sccmazm

formlattcr of August 1%, 1983.

mulcmawmciatcthsmdtomkajudmtsmﬁnbasis
of limited information, I do balicva that
have facilities
as

W.Inhallba

michmaybaofvalmtoﬂwbiclogicalaspectaofmm
,

inWashimton to attendmtinga cfthe NIH
Mitt-c on Clinical mug Evaluation on Septmbcr 39 Octubar let. I mum appreciate the cppcmtmity to discuss
with you personally on the late. crux-1m of
cm

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2200
p.13.

Thank you

for your cooperation.
Sincerely 3mm,
Max

HP!“

Fink.

Dhactcr

H. D.

�</text>
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                    <text>4

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Dear

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umiatim with Dr. hurry Layout: ininomjmctim
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Fink, PM).
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Max

Dinky

�</text>
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                    <text>73I—0121

January 5, 1973

“ull”-xa

an

'm'w

«w.

‘r‘l—

,

Greenville Industries Inc.
Bancroft Estate Road

PO

2312

Wilmington, Delaware

19899

Gentlemen:
A

few years ago,

at

in e 10 inch length, in

my

former

institution,

we

purchased

which have been most useful. These came
two 'widths', and many colors.

plastic binders for reports,

If you still manufacture these, would you please send me
a page from your catalog with the prices and ordering information, for
the narrow (?k inch) and wide (78 inch) widths.
Thank you.

Sincerely yours,

Max

Fink,

M.D.

Executive Director

�</text>
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W

Dr. Greenwell
Howell Laboratories

Baudette,

MRAAQ‘CDO

Dear Dr. Greenwall:

K

As an academic institution, we are interested in providing
an opportunity for our students to treat manic patients with
lithium carbonate and to observe its activity.

I contacted Dr. Charles Shagsas of Temple University who
me that your laboratories can make lithium carbonate
available for trials and may assist us in filing'an IND with
informed

the

FDA.

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, 24.0.
Professor of Psychiatry

Max

�</text>
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                    <text>August 6, 1968
Dr. Greenwell
Rowell Laboratories

Baudette,‘ﬁ!!tuu!!a
M '\ ﬁxing/5 ¢%c\

Dear Dr. Greenvell:

institution, we are interested in providing
for our students to treat manic patients with

As an academic

an opportunity

lithium carbonate and to observe

I contacted Dr. Charlea

its activity.

Shagaaa of Temple University who

that your laboratories can make lithium carbonate
available for trials and may assist us in filing an IND with
FDA.
informed

me

the

May I request a price list for lithium carbonate, and
permission to quote your manufacturing and other data in our
IND?

Thank you

for your cooperation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>May

I». E.

Under

7, 195a

Grey-W

Semtary

British Medical Association
Tavistoek Square
1, England

Inndcm w. C.

Dear Dr. Tamar:
With regard to the advertisements from tha Missouri
Institute of Psyduatxy, swmimd in our letter of April 28,
please indicate the following nﬁnimum salaries.
For the position in Psxmiatric Research, "minim

salary $12,000

mm?

Psdxiatric

W

For

$5.700; for

per-

Thank you

"1..

'=

W;

g
17“

"beginning salary
Trainin’39,0000
--'~'

'1"

‘

for your coupemtion.
Sincerely yams,
Max

Pink,

Dimctor

M. D.

�</text>
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                    <text>,7.

"m,

vaw’,

my

.m.

W-vauamvn'gu'arwdwvg

u

"»m:ﬂ~1w~rr.;-;K‘FKI’FT'I‘m-rml¥-OF‘VNMW'NVw—ra-r,‘Irv—"MT“;

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-

7.

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A

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;- my..-

June 29, 1970
Mr. George Griffenhagen

National Coordinating Council

Washington, D.C.

on Drug Abuse Education

Dear Mr. Griffenhagen,
Thank you for your kind invitation to participate in
the July 15 meeting at the Chalfonte Haddon Hall in Atlantic City.
As I anticipated, I will be unable to attend, and I have asked Dr.
Richard Resnick of my staff to present our data.
Dr. Resnick is an Assistant Professor in this Department
and has been a project leader responsible for our studies of cyclazocine
since 1967. He has developed a typology of characteristics predictive
of outcome in antagonist therapy, and has been able to deliver a full
cyclisoeine induction in 4 days with minimum symptoms. I am confident
that he will most ably satisfy the needs of the panel, and I am
sending him the material you sent me. He can be reached at the above
address or by telephone at his office (212 MO 2 1899).

Again,

my

thanks for your invitation to

this interesting panel.

participate in

Sincere;y yours,
Max

Fink,

M.D.

Professor of Psychiatry

"-

'W-w

“vvwwm. .mu—mww. w... J”). gnamgﬂmnw-w‘wr-w

mf/

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,

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--

«www- WWI-v“ mmvmh’cv

-

n—W—W w

»

.~—.

'WW... ._,.... _. m’-..‘

"""m"""“""!

‘

March

i0, i970

Dr. John Griffith
Department of Psychiatry

Vanderbilt University

Nashville, Tennessee
Dear Dr.

37203

Griffith:

i am pleased to invite your participation in a symposium
on "Pharmacological and Therapeutic Aspects of Amphetamine and
Hallucinogen Abuse“, at the forthcoming meeting of the GIMP in
Prague, during the period August li—l5, l970. We would like to
focus on a review of sociopsychiatric, biochomlcal and CNS
aspects of amphetamine abuse.

The emphasis is on ”abuse" tolerance and dependence, rather
than amphetamines as a model for schizophronia.

would like to ask you to prasent an overview of amphetamine
other sympathomimetic abuse in the United States, as wall as
your studies on the behavioral effects of amphetamine use. The
invited participants are listed in the enclosed abstract.
i

and

For your

if

you

presentation

you should allow 20—25

are able to participate,

i

minutes.

should be grateful for

return mail.
title
(l have delayed overly long in putting togothor this panel and

a
i

short abstract

(i50«ZOO words) by

about to be chastised.)

am

will

and a

Details of the meeting, as to hotels, location, gtgl.
return mail.

come by

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kp

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                    <text>June 10, 1965

Miss Darby C. Grimes, Secretary
Andrew Berger. Ph.D.

Director of Education and Chief Psychologist
0mm State Board of Control

Mental. Health Division
Salem, Omgon 97310

'

Dear Miss Grime:
‘mank you

for your flimt mservatims.

Because

I

would

like to minimize the amount of time away from the laboratory,
I would pmfor to loam St. Louis at 2:17 pan. on Delta Airlines
mgr: 782 amd to take Flight 51 with Mortimer Airlines which
en'ivos in Portlmd at 8:02 pan. on June 2%.
My

secretary has confirmed these flights hem.

The

mowatim is satisfactory.

Insofar as I will be coming
necessary for anyone to not me.

what hotel

or motel reservations

proceed them directly.

'

late, I

do not

feel

Would you please
you have made mad

mtum

it is

tell me
I will

Sincerely yours,
Pink, M. D.
Professor of Psychiatry

Max

Hfﬁtp

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Mr. H. Hadley

1965

Mm

washinstm Humanity

Linden and

mm Gupta

8t. Ind.- 30, Minnow-1
DurHr. Mm:

ofthe
hawtmetimofthumofmmatm
Research
Famdatim
has
Mn
provisionally
Pandemic

sat far Friday, June '4, 1965, at 12:30 pm. at the Missouri.
Athlatie Club. I! than is new problem with this data,
would you please call my rafﬂes?
Sincemly ,

”in.
m
m,
mania Dir-actor

�</text>
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12 , 1985

Hr. H. Hadley Grim
Washington University
Camus
i
St. Louis, Hieeomd 63130

man

m

Dawﬂacuoy:

Follmingﬂnmolutimofﬂnﬁcm‘dmomoborls,

Ihmtahnﬂnlibemofdmfﬂngmeemlosedlctter
m‘gingﬂwewem to supporting Institute Wt. If
mummwiﬁxmappmvalwouldywplmemditm.
Ifnot,wou1dywcdit itmdciﬁnwhmymmsmtu‘y
mtypoitwnmlmit.
Asmplyofﬂumwstatimayforﬁml’bmdadmis

moluumtom
mammay
Manama.
mismlutimisﬁmsmasﬂutinopemtim
ferthcpmt fowym.
'

submit the enclosed

My

best

mm.

Stanly yours,
Max

-

kap

Pink, NJ).

Win Dinctor

�</text>
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                    <text>November- 22 , 1965

Mr. H. Hadley

Grim

{hivereity

Linden E Skinker Cm»
St. Louis 30, Missouri
,

Deerﬂr. Grim;
Enclosed are copies of the Board's resolution
mgarding the budget of the Missouri Institute of
,Peydmietzy, whim was sent to the Governor, and the
,Govemor'e reply which is sent to you foryam

infmmtim.

‘

1) Themxtmetingoftm Pommdetionwillbee
meetmg on ‘meedey, Jamar-y u, 1966.411:
1mm
pan.
at the Missouri Athletic Club (ROS Washington,
(12:20
St. Louis, Hiaeomi) The agenda will be short and it
is planed the meeting will end before 2:00 pm.
Sincerely yams ,
Pink, NJ).
Executive Director
Max

HF:kp

,

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                    <text>January

12 , 1966

Mr. H. Hadley Quinn

linden

Mummy

Skinkar Camus
St. Innis, Hissouri 63130
8

Dear Mr.

Wu:

Pallwing tho Molmion of the

Board

of Directors

would you please sign the resolution autemnts and
319mm cards and send than in the enclosed envelope

to ﬂu

3mm Bank.

Sincerely yours ,
Fink, H.D.
Executive Director

Max

Hszp

�</text>
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                    <text>339W)? 25,

1963

WW:

Iwuldba mteful ifyouwouldcmeidertha 1'01le

quantim far discussion at tin

mt muting of the Fomdatim

SimldﬂnPsychiau‘icanmthaﬁmapplymm
Lhit‘GdW?
.

_

'

Iaakedl-k‘. Stuammmilshaﬂwught ﬂammuldbo
a reasonable_quostim
to author as
service oriented, I still would be grateful sufficiently
for the Fomdatim's
mm;

u

m

Wampwtmipaﬂonmmmimd

Sincerely yours .

m Fink,

M.

n.

mantis“ Director

�</text>
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                    <text>Dimmer 19,

m.

H.

1963

WW

Munster:
Unimity
Linden G Skinker Campus
8t. mail: 30, Missouri

mm. Grim:
mterial

V

Wmmmﬂzformmoofthnmclm

which

I

am

mtming herewith.
Simmly
Max

Pink.

mum

Mleg

an:

1

m,
M.

D.

�</text>
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                    <text>my 21,

1964

Dr. Roy ‘o Grinker, 3r:
Chiof Editor
itchisos oi Gonoral Psychiatry

Inotituto for roychosonotio and
rlychiotric Rasoaroh

29th and
Chicago,

lllia

Asouuo
60616

Illinois

Dear Dr. Grinkor:

I on taking the liberty of enclosing three copies of a report
ontitlod “Clinical Efficacy of Chlorpromazino—Procyclidino
Continntion, Iniprolioo and Plocobo in Doptosoivo Disordoro"
for your consideration for publication in the Archives.

During tho past few months, the Clinical Committee on Drug
Evoluotion of tho Psychophoruocology Service Center has boon
proocoapiod with tho dovoloonont of a national collaborative
atndy of drugs in tho trootuont of depressivo illnoaoou.
Stimulatod by tho diocuooioa. I roviauod none of the information gloonod during tho studies ot Hillside Hospital and this
toport toflocts that experience. I anticipate that the Poychopharmacology Sorvico Contlr will undertake a collaborative
study roplieoting this otudy comparing Chlotpronotino and pro~
oyolidino. i-ipro-ino and plooobo. tit would bo helpful it our

experiences wore availablo in the public prool.

Thank you

for your oonoidorotioa.
Sincoroly yours,

“at,
m
Diroctor
Mrljb

“Co

K. D.

�</text>
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                    <text>may 21, 1964

Dts Roy Rs

Gumt.

3r.

Chisf Editor
Archivss of eanaral Psychiatry

Institute for Psychosomatic sud
Psychiatric Rssssrdh

29th and
Chicsgo,

Ellis

Avsaus
60616

Illinois

Dear Dr. Grinkst:

I sn tdking tha liberty of enclosing three copiss of s report
untitled ”Clinical Efficscy of Chlarptomszins~Procyclidins
Combinstion, Imiprsnins and Piscsha in Deprsssivs Disotdsrs"
for your consideration for publication in the Archives.

During tbs past fsw months, ths Clinicsl Committss on Drug
Evaluation of the Psychophstmscoloxy Survice Cents: hss bssn
prsoccupisd with the dsvslopmsnt of a national collaborativs
study of drugs in the trestnsnt cf dcpressivs illnesses.
Stimulated by the discussion, I raviswsd some of the interns—
cion slesnsd during the studies st Hillside Hospital sad this

tspott rsfiscts that experience. I anticipate that the rsycho-

pharmacology Ssrvics Center-will undertske a collaborativs
stuﬁy tsplitsting this study comparing thlorpronssins and procyclidins. iniprsnins sad placate. tit would be helpful
our
sxpsrisness wsre svsilsble in the public prsss.

it

Thank you

for your considerstion.
Sincerely yours,
Fink, “0
m
Dirsctor

HF/jb

nae.

DO

�</text>
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                    <text>,

DP. Ray Ry

37?.
WM.
of Psydﬁatxy

m

30, 1965"

,

Illinois 50616
(him, W

Bapavman‘t

Michael

Hospital

Daar ﬁr. Grinkar;

I

taking the appor'tmi'ty to enclose two (spies of a
mpozﬁ: "Sociogsyckwlogical Aspects of Psydziatric hmtmnt
in Times Vohmtuy Hospitals“ for your outsidemticn for
am

M.
mismmsmtsastudymakmsmm

publication in the

and myself at the Wide Hospital.
mam
Wehavaacidadtosubmitmis for Mileatim, inviawof
._

ago by

my

ﬁamnﬂmndintemtinﬂxesmialmpemofdamis

madmatmt.

-

Sincerely yams,

Maxﬁnk, H. 1).
Professor of Psychiatry

�</text>
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                    <text>June 15 , 1965

Dr. Roy R.

War,

Sn, Chief Editor
Archives of General Psychiatry
Institute for Psychoaaaatic and Psychiatric Research
291:):
‘

Street and Ellis

Chicagc,

Illinois

Avenue
60616

Dear Dr. Sumter:
Enclosed are three copies of the manuscript entitled
"Sociomychlogioal Aspects of Psychiatric
Treatment in
Volmtar‘y Hospitals," as mquested in
ymr recent
letter. I am also enclosing the mdical abstract
I have pmviwsly sent one to Dr. Dmilevicius, as card.
he had
mquested this about ten days ago.‘Ihank you very mch

for your interest.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

24?sz

encloma

�</text>
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                    <text>Harch 11,

Dams: m,
Dr. Roy R.

Michal

3.966

8v.

of Pmaiatr'y

Rouse Hospital
(3mm. 11111013 60618

WW.W
our report
Er. Itil m I m phased to
Dulirim
Immad
mug
(We).forWientim,
crow
Bahaviaml WW)"
your
Qantitatiw Em
"Anti~

submit

W

and

05
Wu“
a
omofmidzhaa
Immoloaingtwompios.

outsidemtim for publicatim in the

Nam.
notofﬂnmiﬁmlﬂgtm.

Imatﬁﬁawmmtmthymmappmval.
Simmlyyoum,
Max

Fink, PhD.

mensm cf

Psychiauy

�</text>
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Gm,
Institute for Payehomtic

Dr. Roy R.

and Psychiatric

AW

29th Strut am E1113
Chicago, Illinois 60616
Dear Dr.

1966

W

Grim:

Hyumhtumdlmpmaedmmitthemclosed

Mjecta"
mpm"mmodmmnmmmuminpmmm
tho
Mauvu.
for
m Wham“ in
for your midnmtim

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Wvumingmwtfwmmtwﬂﬁsmiwofw

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Win agent in the mmnt of lmg~m psynhoties.
Thank you

for year midnm’cim.

Sinoemly yams,
Hm:

Fink, H.D.
at Psychiatry

Harm

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October 20 , 1967
Dr. Roy R. Grinker, Sr.
Chief Editor

Institute for Psychosomatic

and Psyohiatric Research
29th Street 8 Ellis Avenue
Chicago, Illinois 60616

Dear Dr. Grinker:
Hy associates and I are pleased to submit the enclosed
report ”Thioridazino and Chlordiazepoxide, Alone and Combined,
in the Treatment of Schizophrenic Patients" fOr your oonsidera~
tion for publication in the A.M.A. Anchiveé 05 Geneaat
Psychiatny.
This report is the first part of three describing the clinical,
EEG and then relation of EEG and clinical
effects in a carefully
controlled study.

Thank you,

in advance, for your cOnsidenation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST lOZND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT

OF PSYCHIATRY

RECEIVED

JUN

June 24, l969

301959

R. .W. MAYQ

Dr. Roy Grinker, Editor

Archives of General Psychiatry

American Medical Association
535 North Dearborn

Chicago,

Illinois 606l0

Dear Dr. Grinker:

writing to request permission to republish a figure
my reports which appeared in the Aachiveé 06 Genenaﬂ
Paychiatny. I would like to include this figure in a summary of
our experiences with depot fluphenazine which will appear in a
volume entitled "Changing Patterns in Psychiatric Care", edited
by T. Rothman of Los Angeles.
I am

from one of

May we

have permission to republish the

figure

from the

article "Long-Acting Phenothiazine (Fluphenazine Decanoate)
Treatment of Psychosis" which appeared in Vol. l8, page 479?
Thank you

for your cooperation.
Sincerely yours,
Max

ﬂ“, EMA,

Fink,

M.D.

Professor of Psychiatry

MF:kp

cc:

7x3

Miss Hawkins

PERMSSSSCN
UPON

swam

5,
cam-nan, CONTINGENT
APPROVAL BY AUTHDR.

JOHN H. TALBOTT, MD, EDITOR. JAMA

‘33

DR.TALBOTT
&lt;'

JUL 2

$5

‘9

3
‘33

§§¥ {Kg

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June 24. 1969
'rw-w'nww-ur-pw.

Dr. My Brisker. Editor
Archives of Genera! Pa chiatry
Marian Medical Assoc etioe
535 North Durham

'

Guiana. Xiiimia

60610

Dear Dr. Brinker:

i as writing to request per-iaaion to republish a figure

aredinthemumaﬁw
thia figure in a emery of
mid like to mlude
ma «pot fiuphenuine which will appear in a

fmmofwreportawhicb
1
Pa

.
our expe emu
roiuu entitled
by T. Reuben

of

“Changing
Lou

Pattern: in Psychiatric Care“. edited

Monies.

have permission in republish the figure from the
Phenothiazine (Muphemine Decanoate)
articie
Treatment of Psychosis“ which appeared in Vol. 18. page 479?
Meg we

Long—Acting

Thank you

for your cooperation.
Sincerely yours.
ﬂax Fink.

"m'kf‘qaf

.

‘0:

ng-p-r-z-«yaw

cc: Ilia:

u.-,

Wy

.un

*7

"‘3‘”!

i=1"

Lv

«-w"‘?mW

..
7m

M

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&lt;

1'5“"

mwe;£¥§

.

".0.

Professor of Psychiatry

:

Mina

�</text>
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27 , 1967

Dr. Roy R. Grirﬂcer, Chief Editor
Psychosomatic and Psychiatric Institute
2959 South Ellis Avenue
Chicago, Illinois 60616

Dear Mr. Grilﬂcer:
Enclosed is a report ”Long-Acting, Depot Phenothiazine
Treatment of Psyclnsis“ for your consideration for publication

PaycMmy. In our studies of the
severe, long—term chronic mentally ill we have found the
parenteral phemthiazine most helpful in the treatment and
maintenance of these patients , and, this usefulness has stimulated
us to prepare this report.

in the Mauve:

Thank you

05 Genemﬂ

for your consideration.
Sincerely yours ,
Fink, Ml).
Professor of Psychiatry

Max

ffzicp
enc .

�</text>
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wen-"11.:

“war

W:-

umz‘

»

2M7
7383-63783
relax-nary 26th, 1973

Dr. Ellen Orin.
Department of

thiatry.

University of Unitarian, School or
The Canter for tho Health Seances .
Io: A1391“. California 90023:.
Dear Doctor

mum,

Grits,

M: the present time April and ma 39d are both open
and I will be glad to sea
If you will dascribe the
causation: which you would like to have wavered I «I:
make the
either in Kw Kerk city or at
Stony Brook.

NW:

m.

You may be particularly intmated in a.
tux-mind by Columbia. University an Wednesday,

senior:

April Mia
and! Thursday. April 5th on the subject "Drug abuse:
amount and Paychotomimica" which is being unwind

by Dr. Luce Bimpaon of the Department of
$33.8.

mmcolog

I look tome! to swing you.
Sincerely yours .

Mt: Pink. ”and

Protcumr of Psychiatry

19/13

gt

�</text>
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                    <text>July 3. 1969
6. Grodberg. Director
Research and Development

Mr. Marcus

Davies Rose Hoyt
633 highland Avenue
Needham. Massachusetts 02194
Dear Mr. Grodberg:

principal phase
study program are:
The

Sidney Merlis

Arthur Sugerman
Donald Gallant
George Simpson

I drug

evaluators of the

HIMH-ECDEU

Central Islip State Hospital, N.Y.
new Jersey Neuropsychiatric Institute
Tulane University
Rockland State Hospital

men are accustomed to evaluating new psychoactive drugs,
but do not usually report studies of sedatives.
There are also a number of fine researchers in Europe who
are now doing phase-I studies. often at a cost less than USS.
investigators. and with U.S. investigators as monitors or co—
analysts. In one study, the data was prepared on NIMH-type
forms and analyzed here. There has been some discussion as to
whether such trials can be included in an FDA submission. This
objection to foreign work is to my mind, not relevant in phase I
studies. where drug toxicity and dosage are the principal questions.

These

If such a European trial interests you. my laboratory may be
able to monitor and process the data. One advantage of a European
trial is the possibility that some EEG data for classification
purposes may be obtained concurrently.

It

was kind

suggestions

may

of you to

be

helpful.

visit

my

laboratory.

I

trust these

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

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A
\ng

February 28, 1970
Miss Janet Grono
Delphoo, Ohio
Dear Miss Grone,
Your letter to Dr. Taylor was sent to me for roply,
since Dr. Taylor is now in the military service an&amp; is unable
to continue his brilliant work. The war in Viet-Nam, which is
so destructive of lives, is also destructive of other good things
in our societyv~ including research.
The boat has already been published, and there have
boon no other studios. I hope that as soon as the military
releases Dr. Taylor, he will return to carry on this important

work.

Good luck

in your studies.
Sincerely yours,
Hot Pink, M.D.

Professor of Psychiatry

P.S. For a good discussion of schizophrenia, may I suggest you
request any textbook of psychiatry, particulariy the
Comprehensive Textbook of Psychiatry, edited by Freedman
and Kaplan, published by Williams &amp; Wilkins, 1968.

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April 9, 1935

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wmutmmmmsmms.
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Mr. Manfred
Winn VIII

June 7, 1965

6. Gross

Hidcmbmgmse 3/17
Daarﬂr. Gross:

first

Wamlodcingfmamtohavingyoujoinmdmingthe
Yom‘
week
of July.

appointmt has been approved by the
official copy if waiting for yuu
here. I mamlmingadmft ofﬁaepmpoeedpmtoml ofthe
University of msaoud and an

studyasmllassmofthemportswhidmyoumymad.

The

mlyadditimalbookthatlwouldsuggestyoumadisﬁmme
writtm by Dr. M. 8. Radar, WAMdMA in Pmcepdan, Springfield,
1952.
Illinois: Charles
I look forward tohavingyouworkwith me.

W,

Sincerely yours,Pink, H. D.
Professor of Paydxiatvy

Hax

Hfskp

011de

�</text>
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                    <text>Septenber 2a,

1965

Miss Evelyn R. Gross-berg

Flames Press

c/o

mute114Bmeu Interprises , Inc.

New

York,

Dspmr
227 W. 17th

Street

New

York 10611

Dear Miss Grossberg:

I

’

melanin; the galley pmof of the contribution
in Mental Illness: Anticholinergic
"molinexgie Modunim
” t0 Volume VIII of the Recent Advaneu in
Hell
am

PAW.

Bishop

is the intmmwtim to the papers by
Mite, Itil. Esteban. ma wilson. Insofar as
these reports represent a «intent and organized presentation
sf :1 single subject, I would like to request the publisher to

Dre.

This pmsontatim

W.

reprint this set of articles om issue them together in a
single cover. Sum a wiletim would be helpful to each of
the participants and I would mdwtake to, mdemite such
eonplete reprints to supplemont individual senders by eedm of
the contributors.

in quantities of

is

The

{My I ask fer
100 or 200?

a quotation far such reprinting

order for individual mprints for this emtribution

enclosed.

Thank you

for your m—opemtim.
Sincerely yours ,
Fink, 14.1).
Professor of Psychiatry

Mex

MF:kp

�</text>
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                    <text>October- 29 , 1965

81703st
Smrvisor

Evelyn R.

Editing

Plums: Press
227

New

Hut

York,

1713:
New

Street

York

10011

Dear Miss Gmaberg:

I regret that these prod-fa hm

been delayed, but they
this morning.

inmetly,
I mid appmciata ymr cor-mating the addmss of norm! to:

had ham addressed

and reached me

Missouri Institute Of Psychiatry
sumo Arsenal street

'mnmmly yours ,
Max

14de

Pink,

PLD.

Professor- of Psychiatry
'

'

�</text>
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                  <elementText elementTextId="106292">
                    <text>May

Dr. Hanna Grosz

12, 1971

Ap

University of Indiana School of
Medicine

St.
Indianapolis, Indiana
1100 W. Michigan

76207

Dear Hanns,

It

was good

to

meet you in Washington and I enjoyed our
I am enclosing a copy of our letter and

discussions of lactate.

our summary report (unpublished) of our

lactate studies.

Michael Taylor is interested in continuing these studies on
from military service in July. He has proposed to
first test your suggestion of testing the specificity of lactate
ion by repeating the trials with bicarbonate. As you have already
done this study, it would be most helpful for us to read your
report. May I ask you for a preoprint?

his return

The lactate experience is probably non-specific, as you suggest,
but further study, particularly from our frame of reference of
testing new psychoactive drugs, is of interest to us.

I am also enclosing our most recent
of the narcotic antagonists.
My

summary

of our studies

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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92

Dr. Hanus Gﬁosz

Department of Psychiatry
University of Indiana School of Medicine
Indianapolis, Indiana
Dear Eianus :

ulate

I found the session

by the

stimulating, and congrathope you will not be intimidated
difficulties and proceed with your studies.
Wednesday most

you on your enthusiasm.

administrative

I

Your reception by Dr. McGlaughliu was most cordial, and I
an confident that they will support your work if they can.

I did not offer to undertake the heroin challenges, because
my laboratories from the city and now lack facilities
to do studies of Opiate antagonists. (One factor in my decision
was the prolonged arguments this work engendered « work which arouses
passions, and makes sensible men intemperate).
I

am

moving

direct assessment of the
associates will assist you

Should you wish to undertake the

narcotic antagonism of prepranolol,
in any way they can.

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Gardner 1%, 1963

Mr. Rama

J.

Grosz

Indiana University

Meal

1100 West Michigan

Stmt

Imtitute of Psymiatric

Indianapolis 7, Indiana

Center

mm

Bur Hams:
bank you very mach for your letter remmmg Dr. Sem~
fetinidea. We have midemd his appointmm: very aeriomly and
omtotmamelusion thatwealmadyhadamtrmavymis
While I maid be delighted 135 have
on clinical
himmrkwithme. I donot feel matm muldmnitthe imtitute'a

Wolow.

limited funds at this
My

12513;.

best regards.

Sixm'ely yours,
ﬂax Pink.

Wzmlg

M.

D.

�</text>
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                    <text>December

ll,

1968

Honorable Wallace Groves

President.

Grand Bahamas

Port Authority
Freeport. The Bahamas

,

Dear Mr. Groves:

visit to Freeport, attending meetings of the
of Psychosomatic Medicine, I was favorably impressed
by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
In a recent

Academy

that there

was a need

fer additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
We have talked of possibilities of expanding our programs
to other communities. to allow for the insights which come
from comparative studies.
I

do not know what

facilities for psychiatric care are

if

there is either a need for or
an interest in the development of a community mental health
be able to fulfill such
progran, it is possible that we may

available in Freeport, but
a

serv ce.

would be pleased to hear from the approoriate agency
of the Authority regarding this suggestion. Let me take this
Opportunity to congratulate you on what appears to be a
visionary and exciting program.
He

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>Becember

ll,

l968

Honorable Wallace Groves

President,

Grand Bahamas

Port Authority
Freeport, The Bahamas
Dear Mr. Groves:
In a recent

Academy

meetings of the
was favorably impressed

visit to Freeport, attending
I

of Psychosomatic Medicine.

by the tremendous progress and activity which I saw.
Representatives of one of the development companies indicated
that there was a need for additional medical service.

This Department of Psychiatry has extensive treatment,
research and teaching programs in community mental health.
we have talked of possibilities of expanding our programs
to other communities, to allow for the insights which come
from comparative studies.
I do

not

know

what

facilities for psychiatric

if

Care are

for or
there is either
health
mental
an interest in the development of a connmnity
program, it is possible ' that we may be able to fulfill such

available in Freeport. but
a

service.

a need

.

we would be pleased to hear from the appropriate agency
of the Authority regarding this suggestion. Let me take this
opportunity to congratulate you on what appears to he a
visionary and exciting program.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>A:

.vr-rn-me-wmi—

:kﬁl‘

47,14;

«:

r
1wggnz¢¢ggl

Fig-rm-

ﬂovomber 26, 1969
Dr. Michael L. Grozier
Associate Clinical Research Director

The Squibb
New

Institute for Medical Research

Brunswick,

New

Jersey 08903

Dear Dr. Grozier:
In response to your request regarding clarification
of our table of fluphonazine decanoate onanthate, dated
NovoMber 12, 1969, I have inserted tho clarifying footnotes
regarding the Source of the "raw data” and "summary“.
—

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszp
6110.

�</text>
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                    <text>"""W"?

a.“
L‘

1

November 12. 1969

Dr. ﬁichael L. Grozier

Associate Clinical Research Director

The Squibb
New

Institute for Medical Research

Brunswick,

New

Jersey 08903

Dear ﬁr. Groaior:

have reviewed the clinical records and the summaries
of forty patients in a cross—over fluphenazine decanoate fluphenazine enanthato study completed in our laboratories
in 1968. The report previously submitted to the conference
at Sitges included 62 patients treated with decanoato.
We began our study with dooanoate and many of the
early
casos suffered secondary effects, in part related to the
trials by the staff in obtaining their experience. The data
of the crossover group will be more comparable and a more
representative picture of the secondary effects is shown
on the attached table. It is apparent that the compounds
are quite similar in their effects in this population.
We

.uuuvi'al'

Sincerely yours,

_

'
vi.

.u,

vrww

MM

are-aw»

MF:kp
'xiys‘wwlwﬂk‘,“

-:-

tam.

2..

"nai-

A,TWAWMMK”W'W'?M'VWWW

w

'

"an”

Pink.

‘10:)-

Profossor of Psychiatry

"New."

�ﬁgx

I.“J

Novambor 12, 1969
FLUPHENAZINE

DECANQATE

-

ENANTHATE

Crossover 1967-68

8&amp;ng

Parkinsonism

Elma

m

125

so

FF.

4

3

s

2

4

s

4

4

s

9

s

5

13

17

12

11

32%

42%

1m

27s.;

AN“

Akathesia

&amp;

Restlessness

Other
Sum
%

N

”L

,
~.;.-.

:7

1'...

a;.wmvvv:1.-v:rn

I

40

incidcnce

�</text>
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                    <text>Fix

October 1h, 1978
Michael L. Grozier, M.D.
Knoll Pharmaceutical Co.
30 N.

Jefferson

Road

Whippany, NJ 07981
Dear Mike,

Thank you for sending me the copy of the therapeutic notes
on Metrazol and the reference list. In checking with my files, I find
that I have quoted and referenced most of the articles dealing with
my forthcoming book. It was helpful to
as an independent check on my scholarship.

psychiatric treatment in
have the

list

It is of interest that this publication fails to cite the
seizure therapy use of Metrazol. The citations are up to l9h6, so I
estimate that by that time this use of the drug had ceased, reflecting
the greater ease and safety of ECT.
The volume "Convulsive Therapy? Theory and

Practice" will appear

after the first of the new year, from Raven Press in New York. I
think you will be pleased with the Metrazol citations and discussion.
soon

There are some suggestions as to the usage of Metrazol in the treatment

of

some

patients today.
My

regards.
Sincerely yours,

'::'u;.,.;

a:

WN-Mg.

92"".

M1,!

v-1351Flh9;“§_lﬂ2m;w¥“jﬂ"~“I“

n.9,,”

q

wen“

A»

‘An-viwﬁf—lv

V»
.«rﬂ

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>March 21, 1970

Grune

&amp;

Stratton

381 Park Avenue South

New

York 10016

Gentlemen:

on

my

Kindly enter a subscription to
behalf, effective with the January,

annualyy

Comprehensive Psychiatry
1970 issue, and renewable

until cancelled. Please address the subscription to

office at:

Max Fink, M.D.
39 Arleigh Road

Great Neck,

New

my

York 11021

Thank you.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�March 21, 1970

Headley Bros. Ltd.
Ashford, Kent, England
Gentlemen:

I should like to reinstate my subscription to the
British Journal of Psychiatry, beginning with the January, 1969
issue, if that is still available, and continuing annually until

cancelled.

Please address subscriptions to
Prof.
39

Max

Fink,

Arleigh

Great Neck,

1969

my

home,

M.D.

Road
New

York, U.S.A 11021

receipt of statement, I should like to
subscription and prepay 1970—1971.
Upon

pay

Thank you.

Sincerely yours,
Max

Fink,

M.D.

for the

�</text>
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                    <text>January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

�January 25, 1969
Dr. Edgar Grunewald
Geigy Pharmaceuticals

Ardsley,
Dear

New

York ldbdz

to,

Following your request, we have reviewed our ongoing
ketimipramine~ieipramine study. This second phase was under»
taken to compare the two compounds in a random assignnent,
blind basis following the peeliminary study (Sunnery II: 8-30-65)
and the protocol (3—20—63). The study began in April lees.
To date, 26 patients in the outapatient population of the
Metropolitan Hospital Community Mental Health Center satisfied
the criterion for admission to the study of exhibiting symptoms
of depression, retardation and endogenous features. Of these,
6 are classifieo as psychotic depressions; l7 as neurotic
depressions and 3 as schizo~affective disorders with depressive
symptoms. Fourteen patients were assigned to imipramine and l2
to ketimipramine. Twelve are in progress now.
Of l4 subjects, 6 completed the study period and a were

twaa—nv

:
L

,

incomplete (“drop—out“). The “drop~outs“ were with both drugs
to drug factors. 0f 3 ketimipramine
treated patients each improved and were discharged from the

and appear unrelated

clinic.
after 5

One

of the

drop—out

patients discontinued treatment

weeks therapy, and we have not been able to obtain a
follow—up. At her last visit, her symptoms were ameliorated.

'

Three patients completed the imipramine
much improved (2) and improved (l);

rated as

trial,

being

Secondary effects were few (excluoiny the possibility that
sone patients failed to return because of symptoms assuneo to
be drug related). hith imipramine, headaches and “burning, red
eyes“ (l) and nausea (l) were reported. With ketimipramine,

‘

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                    <text>——-——-—-—m

«n

vumvm

w-wnv

—.,
&lt;

'7

-vm'Fw—uu—n

"v.1..-

W

September 6, 1988

.vmm

w.

m,

a“nun...”

_N—v'y-W

Leon Grunhaus, M.D.
Department of Psychiatry
University of Michigan Hospitals,
D9702, Box, Oil 8
Ann Arbor, Michigan #8109-0118
Dear Leon,
Thank you for sharing your videotape with us. My nurse, Mrs. Caraslti and I
viewed it together. We famd it a fine presentation of case material and the ECT
treatment process. We found no portion to criticize. The overall effect is clearly a
positive one. I have asked Mrs. Carasiti to use the tape instead of our own for the
next few teaching sessions and I will let you know it the patients or their families
have any feedback.
1
am delighted that another tape now exists and 1 encourage you to make it
available
as
to users in other centers as Somatics has made my tapes. I! it does
become available, please let Richard Weiner know so that he can include it among
the list of available teaching materials in the forthcoming APA Task Force report.

Your letter to Harold was enclosed with the tape and lam returning it to
that
you so
you can address the special requests to him again.
My best regards.

Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>September 17, 1968
Dr. Edgar Grunwaldt
Geigy Pharmaceuticals
Ardsley, New York 10502
Dear Dr. Grunwaldt:
Thank you for the ketimipremine placebo. You may recall
patients
that you asked that we discontinue ketimipramine in for
longer
medication
the
been
on
who have done well and have
ketimipramine
on
each
one
have
put
than eight weeks. To do so, we
placebo first and only those who do badly will receive imipramine.
The new

at the

end of

protocol should be

amended

eight weeks.

to give ketimipramine

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

max
MF:kp

p lacebo

�</text>
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                    <text>September 6, 1968
Dr. Ed Grnnuwald
Goigy Pharmaceutical:
Ardsloy, New York
Dear 8d.

Attacbad is a tear—aft labs! from the uvntlable aupply
of placcbo for knttmipramina. ﬁbuld it be possible to make
an additional 243106 capsule: for thlo study ?
Wt

have couplatad aha data analysis of the laboratory

on the first kettm1pram1nc stuay. and
within
to
a few dxya *» I an awaiting eons
you
it
xarax copies of the lab ﬁata to make thé package complete.
and tha

HIMH

I will send
My

material

bets regards.
sincarely years.

Fink, E.D,
Professor of Psychiatry
Max
MF/

�</text>
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W

,

mm'mwvw mnwymwmwwﬁ—u-m..

W

sum-nun“.

April 21. 1969
Dr. Edgar Grunwaldt
Geigy PharmaceuticaIs

Ardlley,

New

York

Dear Ed.
Our ketim1pram1ne study is continuing and we would
appreciate 10 x 100 placebo GY~2277.
My

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry

'71.».qu

Max

A

MF:kp

—

�</text>
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«aw

{mm‘rr.'='w'v"

April 17. 1969
Dr. Edgar Grunwaldt
Goigy Pharmaceuticals

Ardsley,

New

York

Dear Ed,

time ago you requested that ketimipranine be maintained
longer than 6 months in continuous treatment. We reviewed
our casewload and the 6 patients in extended treatment were
transferred to other antidepressant therapy. They ranged from

for

3%

Some

no

to 7k months

on

ketimipramine.

In reviewing the laboratory data we found similar incidences
of values outside our established limits for ketimipramine and
placebo. The incidence of out of range values for this sample
is no greater than that observed in this clinic with other compounds,
includ ng cyclazocine in similar groups of depressive patients.
The out of range values are circumscribed in red. The drug code
is A-K for active ketimipramine, P-K for placebo.
I

trust this data is useful.
Sincerely yours,

«qr—mm

rruruw

am

Max

r"

v,rY"‘-"

Professor of Psychiatry

tavm'ruu

wtr-yvzw

F‘nk . ”o D.

Mszp

�</text>
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                    <text>May

23. 1969

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardaley, new York
Dear Edgar,
have an additional supply of 1m1pramine
for the ketimipramineeimipranine study. A label
is attached.
May

12 x 100

I please

Your daughter

is doing very well

important asset in our program.
Ky

and

is

becoming an

best regards.
Sincerely yours,
“83 Pink. ‘40”.
Professor of Psychiatry

Mszp

�</text>
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Dr. Edgar Grunwsldt
Gutsy Pharmaceuticals
Ardsley, Raw York
Dan: Edgar,
May

I please have an additional supply of 1miprsnins

for the ketimiprsmins—imiprsmins study.
attached.
is
12 x 100
my

A

beat regards.
Sincsraly yours,
Fink, M.D.
Professor of Psychiatry

Bax

label

�</text>
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                    <text>July 22, 1969
Dr. Edgar Gruuwaldt

Geigy Pharmaceuticals
Ardsley, New York
Dear Ed,

I reported earlier,

have had one adverse drug
experience in the kecimiprnmine~1mipramino study. The
potion: developed a severe agranulocytosis aftor inipraaino.
Ho responded to treatmant, and was discharged "recovered"
for this opisodo. A contributing factor may have been the
presence of a nooplawm of the nnsophnrynx - for which ho
had bean previously trantod, and is now boing treated.
As

um

Sincarely yours.
Pink, H.D.
Professor of Psychiatry

Max

Krakp

.nc I

�</text>
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                    <text>July 7.

1969

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardsley, New York

Dear Edgar.
would appreciate receiving an additional supply of
bottles of Tofranil 25 mg (100 capsules per bottle). A
We

10

lable is attached.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

�</text>
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                    <text>November 7, 1969

Dr. Edgar Grunueldt
Geigy Pharmaceuticals

Ardsley,

New York

Deer Ed,

Enclosed please find a protocol of our proposed child
psychopharmacology study progrlm. This study is designed to
give us experience in studying drug treatments in children
and adolescents so that in the future we may be able to

assess

new compounds.

described in the protocol, we are anxious to provide
medication in liquid vehicle. At this time I would request
your assistance in making available to us imipramine in
liquid vehicle, both 25 mg and 10 mg/toaspoon. If 4 oz.
bottles are available may we have a dozen of each.
As

this

In addition,

compound?
My

may

I request 12

bottles of placebo for

best regards.
Sincerely yours,
Fink, ﬁ.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>mm"?

March 20, 1970

Dr. Edgar Grunweldt
Geigy Pharmaceuticals

Ardsley,

New

York

Dear Ed,

Enclosed is our report, “Ketiprauine in the Therapy of
Depression in Outpatients”. Separately, I am sending case
summaries: cepies of all forms; the NIMH Biometric Laboratory

data analyses and duplicates of their output cards; and the
Biodata clinical laboratory outputs.

I regret the delay in completing this study and wish to
thank you for your patience and cooperation.
we would like to submit the report for publication in
the Journal of yew Drugs, if you have no objections. To do
so, I would appreciate a list of published references on
ketipramine, and as many of the reprints as you hay have
available, so that the study can be put in the proper context.

Again,

my

thanks.
Sincerely yours,
“or Pink, 3.0.
Professor of Psychiatry

Mkap
911C.

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                    <text>September 28, 1970
Dr. Edger Grunweldt
Geigy Pharmaceuticals

Ardsley,

New York

Dear Ed,

Enclosed is e xerox copy (with Table I corrected) of the
published report, "Ketiprenine in the Therapy of Depression in
Outpatients”, as published in Pszchosouetics, 11: 342-346, 1970.
Again.

my

thanks for your interest in this study.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszt
0316 .

�</text>
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                    <text>'v-AWW

rw—ww—o.

"Wm

~u

w-W,

November 20, 1970

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardsley, New York
Dear Ed,

Last

we embarked on a sequential drug evaluation study
and adolescents. Seventeen patients have been studied,

fall

in children

and a summary of our

initial

data is enclosed.

vehicle, and a summary
patients received Tofranil in liquid forms
and
are enclosed.
Geigy
the
laboratory
record
of each case
Two

study was both difficult and expensive. As Dr. Simeon
has returned to St. Louis, I have deferred further admissions to
the project.
The

I want to thank

you

for your assistance

and encouragement.

Sincerely yours,
Fink, rm).
Professor of Psychiatry

Max

nrzkt
enc o

�</text>
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                  <elementText elementTextId="106126">
                    <text>wr.”

v... — -ww-—\—- ‘wastuw w-F‘féE-wﬂwm'm
.-

w.“

..

wan-wu-

w.-

"‘4’“! .0.

z-m-y «aw-un-

January 11, 1971
Dr. Edgar Grunwaldt
Gcigy Pharmaceuticals
Ardsley, New York
Dear Ed,

have reviewed the two case records of the ketipramine~
iaipramine study and can resolve the apparent discrepancies.
We

Frieda Ehrenberg.

clinic.

Patient

was

unreliable in attending the

she received active medication and an appointment for March 10. She returned 1/2 box of medication on March 11,
indicating she had stepped medication earlier, estimated as 3/6.
She was referred for group therapy. Her follow~up laboratory test
on 3/17 was evaluated as on no active medication.
On March 3

Millie Mauer. On 2/17/69 she received ketipramine. She
had no medication from 2/10 to 2/17 due to a missed appointment
on 2/10. The laboratory tests were done before the new supply
was given. Since she had no medication for one week, test was
adjudged as on "no medication".
I trust this data is useful.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kt

«Jarv—

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                    <text>February 2, 1971
Dr. Edgar Gruuwaldt
Geigy Pharmaceuticals
Ardeley, New York
Dear Ed,

1‘W'rrrl'v

ma¢n§ﬂp~

W

W.

_

Enclosed are the interim reports of our EEG pilot study
of GPA 1714 in volunteers. we have defined a dosage
is
safe and which alters the EEG of our volunteers. The that
preliminary
data is that of a centrally active compound with an EEG profile
usually associated with relaxation and euphoria.

I have made the necessary inquiries about the
l—Dopa on EEG and have just received the citations
compare the

effects of

GP

41299 to £~Dopa.

effects of

necessary to

I trust these data are useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mrzkt

�</text>
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                    <text>October 23, 1970

Professor Stanley Grupp
Illinois State University
Normal,

Illinois

Dear Professor Grupp,
Our

strategy in studying marijuana users in

Greece

is

possible to do overseas
quite simple-~to answer the question, is it
We
?
man
in
plan to examine 60-80
studies of an experimental nature
the
and
extent of their
determine
known chronic hashish users
and
of
their drug
assay it; obtain neuroabuse; obtain samples
tests and
performance
physiological test data, psychological
and compare
damage;
measurable
brain
have
determine if the subjects
community.
from
their
of
matched
non—users
sample
this data with a
We are struggling with some of our test procedures in another
culture and by the problems of user identification (although we have
governmental cooperation, there is still a problem of user cooperation).
I trust this interests you.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry
(Project Director)

mf/

_

�</text>
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                    <text>*W‘awm"r'wvacwmww ‘13Wm”? menu—w:

,

May

13, 1978

Niroo Gupta, M.D.

Bndo

Laboratories

Garden City,

New

York

Dear Dr. Gupta,

recollection, the studies with
prior to 1973. When I left the
New York Medical College, at that time, there were no supplies
available and all the publications were completed.

naloxone

in

my

tablets

hands

naloxone.

To

the best of

my

were completed

In any case, there are no supplies of naloxone

at this time; nor in I carrying out

any

tablets

studies of

»

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>February 21, 1967
Dr. William Guy

ECDEU

Coordinator for Data Analysis

The George Washington University

Bicmetric laboratory

Roan 601

11% Nineteenth Street, N.w.
Washington, D.C. 20036
Dear Dr. Guy:
Enclosed are the RPR forms that you requested. Incidentally,
there is a lack of clarity in item 5b, since the phase of the
investigation is unclear to me. I trust these are helpful.
My

best regards.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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Dr. William Guy
ECDHJ

Biometric Labcractory

Room 618

11% Nineteenth Street, NM.
Washington, D.C. 20036
Dear Dr. City:

mid appreciate receiving 200 cppies of the Brief
Paydxiatric Rating Scale - Early Clinical Drug Evaluation
Study for use in our wt~patient program. Thank you.
We

Sincerely yours ,

‘11:};

VI

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Pink, M.D.
Professor of Psychiatry

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‘

Dr. William Guy

October 25, 1957

'

.

Project Coordinator for Data Armlysis

The George .Washington University

‘

Biometric laboratory

Roan 618

y

11% Nineteenth Street , NM,
Washington; D'.C. 20036

Bill ,

Dear-

We

have recently begun the oystomatic use of the

far, the staff acceptance has been
Witlﬁnthenexttwonmtfmlwillbewxdingymtm

mating instxwwnts. So

high.

forms
-

and

for processing.

As you know we have

I

ECDLU

am

able to use this

facility for EEG analysis
motor
equime‘nt for data proceosing as

a

well. I anticipate that in addition to participating in the
control data bank, we will probably ask you to send us cards
so tratwoancarryoutmanalysis onmmmm.
_

you have the card format almady established for each
or any of these instnnmnts. If so, could you send me a model
fonnat for each of the insmmnts so that my ptogmrmers can
Do

become.

acquainted with this output.

I look forward to seeing/you in

San Juan.

Sincerely yours ,
Fink, MED.
Professor of Psychiatry

Max

MFﬁcp

~

�</text>
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                    <text>Wis-5+"

m

-n-'r-

‘

new:

W

October

9 , 1967

for Data Analyses

The George Washington University

Blanetxdc Iabomtmy

Roan 618

11% Nineteenth Street, NM.
Washington, D.C. 20036

map I!"

W:

are rm: involved in sattixg up a depression study
it mm be met helpful to have the Hamilton
Rating Scale. If this is available far Optical 83m, muld
you please send us 100 fans as soon as pmcticable?
We

few which

Many

marks.
Sincerely yours,
Max

Fink,

PM).

meeasor of Psychiatry

HEW

�</text>
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                    <text>July l8,

1968

Dr. William Guy
George Washington University

Biometric Laboratory

6l8
ll45 Nineteenth Street, N.".

Room

Washington. 0.C. 20036
Bear

Bill,
Separately I

sending you the additional forms for
our ketimipramine (060l0) and butaperazine (06007) studies.
am

recently received one box of the
global scales. No second box was received.
We

have

We

are now using
that you send

and ask

September.

CG!

(l2)

form 03 (treatment emergent symptoms)
us 200 now and 200 additional in mid-

May we also have 200 copies of the Hamilton Scale (form 08)
and an additional 100 of form 12.

Sincerely yours,
Max

Fink,

M.D.

Profestor of Psychiatry

Mszp

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                    <text>September

2&amp;,

1968

Dr. William Guy

ECDEE Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,
Enclosed is the final questionnaire from my staff.
those have been helpful and look forward to a report

I trust
of the results.

Sincerely yours,
Mix Fink, M.D.

Professor of Psychiatry

“szp

�</text>
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                    <text>September 3, 1968
Dr. William Guy

ECDEU Coordinator for Data Analyses
The George Washington University

Biometric Laboratory
Washington, D.C. 20036
Dear

Bill,

to thank you for the data analyses of our two
studies. butaperazine and ketimipramine. These have been
most helpful and I believe that these results. as I have
presented them to the staff will assure their greater
cooperation in future projects.
I want

Enclosed are data outputs from our present laboratory
data forms. You will note that there are three types of
output - a reading of the optical scan report; a summary
by patient giving a portrayal in time of each of the
laboratory reports; and a summary for each laboratory test
of all the reports in that study.
The data form used in these analyses did not have room
for the drug, dose or route and these have had to be added
by keypunching. Also, the forms develOped in Missouri have
many items which do not come from the clinical laboratory.
As a result, we have created a new fbrm which corrects many

of these apparent deficits.

If

Copies are enclosed.

such a form could be used, and especially if various
be encouraged to carry out laboratory analyses
could
centers
in patients not receiving novel psychoactive drugs but either
placebo, no drug or accepted FDA approved compounds, then we
can develop a set of laboratory standards both for individual
laboratories and for the ECDEU program as a whole. Such
standards would be most useful in answering the questions
of the FDA and of industry with regard to the significance
of "abnormal” laboratory findings.

�-2-

Dr. Guy

September 3, 1968

I shouid iike to make a report of the 01d iaboratory form,
the data outputs, and the new form avaiiabie to members of ECDEU.
Before doing so, I would like to discuss this with you, Dr. Saizman
and/or Dr. Levine - whichever you recommend.

Again,

my

thanks for your heipfui anaiyses.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp
ENC .

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                    <text>January 7, 1969
Dr. William Guy

Biometric Laboratory
Washington, D.C.
Dear

Bill,

Enclosed is a summary of the otudies previously listed
with the Biometric Laboratory from this unit, and their preuent status.

I

have

rocently

had two

additional

members

join

my

staff

and

find that we have only one complate manual for ECDEU assessment (as
rcviaod July 1968). If othar copies are availabla, I would appreciate
two additional. If not, I will hnvu the copy xoroxed.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry
MAX

mf/

mm"4.7'-:.

.

�</text>
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                    <text>March 25, 1970

Dr. William Guy

Biometric Laboratory,
1145

washington .
Deer

Rom

618

Nineteenth Street, N.w.
D.C .

20036

Bill,

called your office yesterday and spoke to Ron regarding
that we needed. Enclosed is the formal request for
the forms which I asked to be shipped yesterday.
I

some forms

I also inquired about the status of the data of our ARR-1900
study and Ron was surprised when he checked our file for he stated
thet nothing was due. He clso checked the files for Dr. Simeon
and the same was true. On December 4., Dr. Simeon sent the date
of our study. I would appreciate your checking.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

enc.

�</text>
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                    <text>April

2,

1970

Dr. William Tabor
Robins Co.

A. H.

1407 Cummings

Richmond,

Virginia

Bill,

Boar

Enclosed is our final report on AHR-IQOO. I believe it is
suitable for publication in Currant Thortpoutic Research and will
Such publication would
submit it, if you think it is advisable.
AME-1900
be
of
studios
useful
were planned.
furthcr
only
if
and

I have received the data analyses from tho Biometric Laboratories
separately I am sending a copy of their report and a duplicate

data deck.
We

and I

are proceeding with our fonfluraming roaction time analyses
will be in touch with you shortly.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MP

:kp

�</text>
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                    <text>nxrm

.

v—

‘

»

--——

rr—twwu-w-mwv.v- w, . ewpu- w. m —

November 30, 1970
Dr. William Guy

Biometric Laboratory
1145 19th St., N.W.
Washington, D.C. 20036
Dear

Bill,
Thank you

for the print-outs

and the cards of the

Hamilton data on our ketipramine study. The data is
most interesting and clear. I have a question about the
what does "p" or "g" mean for ”type”?
summary letter
In checking the new manual, (which is most useful), I
could not find these symbols.
—

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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.

yebruary 2, 1971
Dr. William Guy
George Washington University

Biometric Laboratory
1145 Nineteenth Street, N.W..

Washington,
Dear

D. C .

20037

Room 618

Bill,

Enclosed is the disposition report of our study
Biometric Laboratory and 3 new RPR forms.

Sincerely yours,
\Wl'rl‘"1|"-'?'

.mxr-mvnr

Fink, H.D.
Professor of Psychiatry

Max

u

.y

&lt;-r.,-cu

"WV:

MF:kt
811C 0

list

at

,_

�</text>
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                    <text>April 2, 1971
Dr. William Guy

Biometric Laboratory

St., N.W., Room 618
20037
D.C.
Washington,
1145

Nineteenth

Dear

Bill,

is a dibenzothiepine derivative. It is
lO-dimethylaminomethyl—dibenz-[b,fl-rhiepin—HCI. It‘d
formula is:
GP

41299

Lhz-ﬂﬂ- ((3113)::
s/\‘T/
'
'3

It's

1

\--,,A-)\;/\/

molecular weight

I trust this

\§/\

is

.

(:1

303.9; melting point 263°C.

is useful.
Sincerely yours.
Max

Fink, H.D.

Professor of Psychiatry

�</text>
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                    <text>Fwy—ww—“W wwv~mmwnm~m.

V

m

WW

,

W “WWW—rm,

Jun. 16, 1971
Dru.

W. Guy

and R. Bounce

Georg. Hashington Univcrsity

Biometric chorctory

1145 19th

Stroct, N.H..
Washington, D.C. 20036

Room

618

Dear 3111 and Ron,

Enclosed are eight RPR’: of our

EEG

studies of:

Doxcpin - Panoate vs. Hcl
Doxepin: Biocvcilability
028774
AER 1118
CP 1&amp;368
5 42,548
GPA 1714

01 ~ 63

In addition,

norhcdono, both
the doc: bank.
my

VD

could

clinical

file our studies of marijuanc,horoin

and KEG, should you

If so, please return

8 RPR

forms.

boot rosards.

Sincorcly yours,
Fink, M.D.
Professor of Psychiatry

Max

and

belicvc those useful in

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>July 8, 1971
Ur. William Guy

The George Nashington

University

Bio-attic Laboratory

1145 ﬂinotosnth

St.,

N.W., Room 618

Washington, 13.0. 20636
Dear

Bill,

Enclosed are 3 RPR's for our ongoing studies of heroin
(discotylmorphinc), mothsdone, l-alpha—acetylmcthadol, and
cannabis.
The chemical formulae of two compounds you requested
U 28774 is related to diazepam and is
a d1 tscenic mixture of one of its analogs.

are not available.

OI~63 is a peptide derived from the analysis of complex
proteins. It is a pure crystalline substance but I do not
have its formula. My guess is that it could go into 506 or

505.

Sinceroly yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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