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                    <text>November 2 , 1965

Dr. Alfred M. Freedman
York Medical College
5th Avenue at 108th Street
New York, New York 10029
New

Dear A1:

I have ducked the airline schedules from San Jam to
that Eastern 958 will not run from San Juan
member 15. Instead, Eastern 952 will leave
Juan at 3:05pm and arrive in mm at #:2613111. I hold

Miami and find
to Miami after

San

reservations

can

this flight.

travel agent here indicates that your agent will
probably transfer yam." meervatim from Eastern 958 to
Eastern 952.
The

thank you for the invitation.
Sincerely yours ,
Hex

Fink,

FLD.

meesao!‘ of Psychiatry

Mfzkp

�</text>
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                    <text>Decanter 3, 1985

Dr. Alfred M. Pmadmm
York Mon). College

New

Fifth Amos and

Now

York,

New

1051:}:

York

Strut

mm:
is the

form, completed to the Meat that
will note that some of an listings are
mmoopiosfrommurllerdomnt. Iwouldoxpectﬂmt
ywwilleditthis
mditwlllthmbemtypodeltlurinyow
ofﬁoo or mine.
Tm mom 3mm: application will be completed Holzday

we

Enclosed

diamond.

You

like

office
m
to am“: in

aftcmoon and should be in

by Wednesday.

Now York at 6:05pm at
I m whoa-113d
Kandy on mmday and will
to your home directly.
Bunions diswsing the project, I believe we should take

the ﬁrm to
My

best

go

om those

m

two

mpuoatima in detail.

mam.
Sincerely yours ,
MI)!

M, ”an.

Professor of Psychiatry

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                    <text>December 28. 1985

Dr. Alfred H.
New

mm

York Hedioel College

Fifth Amm at 106th Street

new York, New York 10029

DeerAl,
Winter has actually hit Hissouri and we have had oold and
so
rainy days. I guess I regret not having stayed in Florida
enjoyed
have
hope
you
I
this
point.
show
at
a mten
that I can
your stay.
v

.

of Lancet
helmet! is a special article from the latest issue
We
already
describing one eppmeda to a medioal records system.

franthe'mlme
theBMpmmm, endalsosoma apeoialones
merely the
and
is
it
not
'mese
mine:
are
Comuting Center.

have

applicatim of emery and may to

make such

Center.

a system work in our

with some of the
I felt it was necessary to discuss my leaving
that my
miners of my muting facility md they are nowbewere
about
optimistic
would
While
not
I
support will end this amr.
a position
jmt been offeredconsider
taking him from St. Lwis when he hasshould
an
seriously
WU
that
believe
you
Famlty, I
on the
hesitation
Without
Donald
Mr.
Shapiro.
invitatim to my associate,
oo-workerlhevehadin
Iwouldsaytmthehasbmthebest
discuseed with me is to
which
you
thirteen years. If the program
could eooolmlish the
he
believe
I
be lemoheo with your support,
himself
energy to collaborate
sufficimt
allow
mission with ease and
of evoked potentials
technical
aspects
more
with Roy and myself on the
his 13.32. from
He
be
receiving
"will
or Wiologioel malyeee.
WU this spring and is one rated to he paid $17,500 to start.
his interests, I would be very optimistic
If we could atimlate
about developing a mumphyeiologioel analytic unit and obtaining
NIP swport. His ourrimlm vitae is enclosed.
My

best wishes for the

New

Year.
_

Sincerely yours .
Hex Fink, NJ).

Professor of Psydtietry

Hkap
P.S. Bynowyouheve probablyheardtmtmmoomiesionerheeheen
invited to take Paul Roars place. If he does, theHebrews from the
of the flight of the
Hineouri will be
land of Egypt.

Mount

Whom

�</text>
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                    <text>~.

;.

,1:~7W.;~,..Wm

Arr

”.ch

w

Wrr1~ww$7

.97.

«.

“awn-q

Bummer

Dr. Alfred

New

York

New

York,

H.

30 , 1965

mm

radical College

Fifth Amue at 106th Street
New

York 10029

MAI,
I would like to mean myself of the availability of the
facilities oftheNewYarkmmyoflhdicineLibrmymdhm
writtun to them mmating informatim regarding Fellowship.
The librarim, Miss Annm, indicated mat I will mquim

ondommntbymmfellm

meofwlmmt
01mm,
behalf.

procure the namirmtion blank an
H133

W
I

would be

my

grateful if your secretary would write to
or to Dr. Bernard Pamlla (Semtuy,

Arman

mm

Conﬁrm on missions) of the m York
of Medicine
(2 East 103m Street, New York 10029) wasting a rumination

blank.

I

would be

contact

grateful if you would nominate me, and I will
friends for the necessary additional support.

30m unmar-

Sincerely

yam.

Pink, ".13.
Professor of Psychiatry

Max

Wzkp

�</text>
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                    <text>January 18,

1966

Dr. Alfred M. Freechm
New York Medical College
Fifth Avenue at 106th Street
York 10029
New York,

M

Dear A1,
would be e pleasure to have you visit St. Innis during
in your letter
forthcoming
trip to Fort Worth. You indicate
your
13th
luth of
about
the
be
thrmxgh
or
coming
would
that you
February 13,
Sunday,
on
would
be
see
you
to
pleased
Febwery. I
numbers
of the
meet
have
you
to
would
be
more
practicable
but
1».
February
staff on

It

it

We

W1C! be pleased

the residents during

(I suggested

scum

to have

ymm

you emerge

for you to speak to

subject
visit. If you will select a(madman

aspect of narcotic addiction to the

of the Training Gamittee) we will armge for such a meeting
during the early afternoon of February lu.
The work here is going quite well and I hope to have a goodly
humor of reports completed by the end of April.
My next schema trip to New York is for the Psyclropethologicel
18. I can arrange to stay over for
acting, on Friday, February arrive
one to two days earlier if
that may, February 21, or
be
work
dare.
to
more is some
Sincerely yours ,
Max

Fink, NJ).

Professor of Psychiatry

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                    <text>January 19.

Miml

Now

York

New

York, New York 10029

Fifth

Am

1966

College

at 106th Street

Dear A1.
._

I have received a letter of appointment for 1965 from
Dr. Snyder's office with the request that mmbership in the
association of the Americana Hadieal College is

Wand.

Enclosed is my applicatim which should be forwarded
Dr. Snydur's office.

Sal-manly yours.

mm, M).
Professor of Psydliatx‘y

ﬂax
Hf'mp

t0

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                    <text>5mm 28,

1966

Dr. Alfmd
New

M. Freedman
York Median. collage

Fifth AW at 108th Street

Nu York,

Hm York 10029

DoarAl.

I
Mmmmmrmlamrofappoinmmt.
lodtforwudtojoiningyowstaffinlmhprilmm

mthmMammmingfulmtxﬁmm
mWofmmtmym.

to

MmafwmmmmmSMImld
led itbe

liketo discuss betmymviait inFebnm.

mmhforymtomnmatymhimmemmy
athemnwmday? Iwillbeamymﬂmday.
Cmywmfimymmviaitmhbnmylﬂ?

Wahava

MWmtalkaa"WofDmgMdiaﬁm."
mnwmdmgcdifitismtmptabh.
Hybastmsards.
Sincerely
Max

ym,

Firm. NJ).

Professor of Psychiatry

�</text>
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                    <text>Polmxary u, 1%6

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Dr. Alfred H.

College
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DearAl,

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and the coupler“!
application sent directly to Jonathancollated
Cole,
the
procedure will
he coupleted. I am
waiting to him to indicate that this will
arrive about two weekahtc.

I

atmldalsolikotoemﬂmayvisitwimyouon
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IhaminvitedDmShaplmtomtoyour
office about 10:00
am. Attached are m-mpies of his

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31ml);

yours.

ﬂax Pink, M.D.

Professor of Psychiatry

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                    <text>Faraway 28, 1966

mm
Mien].
College
ka
Fifth Avenue at 106th 3mm:

W. Alfred

M.

New

York,

New

New

York 10029

MAI:
Imwridngwithmgardtotm collabmtionyouhnve
with Em. Jun.

minus available

Ihawmvmdtlmeitatmmd

laboratory md find that they are
prﬁuipnny of three kinds. The majority relate to studies
mitiandmtwmmtim
ofﬂnmmmdmnmwith
normal subjects. Edema in this
in paydmotim and

in

my

m

regard go back about twelve

m

yum.

are two reports, one of mien is in 1965. describing
theEEGWinmilctwodaclmimplmiawithmenphmis
an the

for

on

two

EEG

Mt mm.

with
Finally, I haw citations
reports regarding the effect of ninhmide and Hajeptil
and behavior of psydmotie subjects.

W
bolim

indxmd
Of these thm subjects, the
tropic drugs on EEG and behavior is prdnbly the

mast

coma intemst, although I

by psycho-

m of

that their wntzibuticn

hasbeensmllintrdamgazd. ,Ifﬂzeymintematedin
such a
abject, than this is mt easily done.

W
that their
I

tia

in conditioning
believe
greatest
utudiet. Unfwtumtely, I have done 0 the“, and if this
booms a primipal focus, I believe that Roy would have to
.bo involwd aims he has dam such studies.
-

thatofEEGcmain
Mrthizdamofintemst,
another
subject in which we
is
mum.
both have been interested and could be established if we
available
sdﬁmphmnic

.--__.

rupn,»

.
n
m”.

‘

Ugcrw

or,“

-»-;

1.9.,-

-v.«-;-1¢-:w4-..&lt;

gram-.—

'1

pomlatim of adolescent Wopm’enms
for study.

had a

.

�Faraway 28, 1966

mm
Mien].
College
ka
Fifth Avenue at 106th 3mm:

W. Alfred

M.

New

York,

New

New

York 10029

MAI:
Imwridngwithmgardtotm collabmtionyouhnve
with Em. Jun.

minus available

Ihawmvmdtlmeitatmmd

laboratory md find that they are
prﬁuipnny of three kinds. The majority relate to studies
mitiandmtwmmtim
ofﬂnmmmdmnmwith
normal subjects. Edema in this
in paydmotim and

in

my

m

regard go back about twelve

m

yum.

are two reports, one of mien is in 1965. describing
theEEGWinmilctwodaclmimplmiawithmenphmis
an the

for

on

two

EEG

Mt mm.

with
Finally, I haw citations
reports regarding the effect of ninhmide and Hajeptil
and behavior of psydmotie subjects.

W
bolim

indxmd
Of these thm subjects, the
tropic drugs on EEG and behavior is prdnbly the

mast

coma intemst, although I

by psycho-

m of

that their wntzibuticn

hasbeensmllintrdamgazd. ,Ifﬂzeymintematedin
such a
abject, than this is mt easily done.

W
that their
I

tia

in conditioning
believe
greatest
utudiet. Unfwtumtely, I have done 0 the“, and if this
booms a primipal focus, I believe that Roy would have to
.bo involwd aims he has dam such studies.
-

thatofEEGcmain
Mrthizdamofintemst,
another
subject in which we
is
mum.
both have been interested and could be established if we
available
sdﬁmphmnic

.--__.

rupn,»

.
n
m”.

‘

Ugcrw

or,“

-»-;

1.9.,-

-v.«-;-1¢-:w4-..&lt;

gram-.—

'1

pomlatim of adolescent Wopm’enms
for study.

had a

.

�</text>
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                    <text>Ham 1,

1966

New

Dr. Alfred M.
York Hndiaal Gallup
Fifth
at 106th Street
New Yam. Haw York 10029
New

Am

MM.
MImﬁomdtoym,Imnp1emadtomeloaeacopyof

the auricultm vitae a!

E.

forapositlminmnamofmmloformmidemtim
. Ifimtbeem‘
mudwithmmmmwmmampmmmfmu
hmdmtomﬂrm’ngandomdmgtheobaarvatimsmdeby
Richard P.

mitts,

.Bumr'agtmp.

wmmmfwyemlmadlittlaofhiswritings
I began to review ms arbliner‘gic mdmism in

1962 when

until

psycmu'opic

drugs.

Imfmmmmmmmmmwhpmlogy

spring,

hemminvitod participant.

ofanticlwlimmiuagmts. Inﬁnsuamedingyem,mworkm
mtimndinﬂdsdimctimmdwtmnmommiwdamosimm
mﬁmnlixnrgio drugs at the Socisty for Biological Psychiatry last

thmmmtmtymmtmdhxgmdamﬂxmm
Immntlysenthimawpyofmymviewof
Wad.
shamanism in convulsive therapy for which he provided
(homage
a Wtful and helpful critique .

have

InourplanstowgmizethefortrmmimmSympmim,ny

W.

mmdationtom‘. Bmdlaythathobeinvited was imdiately
Ibcliowyouwﬂlhaveanoppovtmitytohaarhimat

that mating.

meossiaully, I

to our

form

have found him

muting.
I hope that this in Mlpful.

likable and I

look reward

Simmly yams,
Ha):

Fink, H.D.

Professor of Psydxiatzy

�</text>
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                    <text>March 17, 1985

m. Alfmd

New

York

New

York,

M.

Madam

M1031

6011934:

Fifth Amman at 106th Street
New

York 10029

Ilsa:- Al,

Aslmntiomdmyuu.1hmbmeomctinginmtim

mmuwmmdchmybemdformsempmesin
Bumps. wtnuiryformyhasmtomgm,sinmfmds
Masﬂneenclnsadwpies
mmtwailablamthstmm.
indicate, meauablcinmlmdmdpemapa this
infmtimwouldbetnlpfulforym,attmﬁnnma:tym

thmfensorJus.
I have

minted the sense of mm discussions with Don.

misquite inmtedbutasayamgm. the ultimate question
isﬂntoffiwmialsuppom. Imxldbegmmfulifwumld
mimhismmdwlmvitaeandmllmatymmlstsmto

mmgsmmmduwopmte‘mmmmm
mmmmm meetiwmfimtofﬁmyear.

m m.

Simly yams,
Fink, H.111.
Professor of Psychiatry

Max

�</text>
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                    <text>April 11,

1966
_

W
W
(binge
Fifth Am at
Strut

New

11'.

“n
York Radical

New

Yam,

New

106th

York 10029

MAI.
Iumtﬁmtymmmtingswithﬂlﬁllermmwn.
metmkmMchmmmmdiﬁMfm
inwatigaﬁ‘pne with cyolamcim. 'Iho Watims am still
misunt'deamquimplmdwiththestMyaofw. We

mmmMHimmomdsm,mtofWiats.

Iwiuﬂyinmﬂcwfokammingmdwinm

Asymmystillbein
tomtxwonmmmﬂaymg.
CalifomiA,Iwwldhamfulifyouwou1d1eavemmml

WMMMmMthmmwgemm
Mdaywmauy.
31m

Aslmtiaud,1hwebminvimdmpmicipataintha
April 21mm.
visitatﬁﬂmmmdaymdrriday,
the festivities with Dr. Bleultar.

miswillmuimmmmiaa

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valmbhfwutobeatﬁnmmcomgeatmtim,I

wﬂlmlaintom.

.

$5le your: .
Nam

Fink, NJ).

meessm of Psychiatry

Wzkp

P.S.

WyouwouldlikotostopbymymmwaytoCaIifomia.
Iwillbo availableaumkmtil Friday evening. 1mm!
beplemdmsrmywaboutﬁxehbomtoriwhm.

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                    <text>A

May

Dr. Alfred

Chaim.

M.

W

81, 1966

Com-mar Ooamittoe

Yeti: Medial (blaze
Fifth Avenue at 106th 8W1:
New York, New York 10029
New

mm...
Follawing your

Wtime, I have recently prepared an

appliceﬁmfmemmrwmntmichiebeingemttedtotm
Public Health Service
EEG

entitled ”Quantitative
Studies in PsychoThat applicatim pmvides for the 'm-eetablismmt

Way.”
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mam

ermpheloy-em mick“: has been explored in
for the past four
were. At the present time, the equipment in St. [axis is based on
an m»: 1828 amtrel
and the mtnllatim is deawibed m
an IBM-1710 emtml system.

pm

Inmiadngﬁefmilitiee ettlnﬂew‘lommdicalmnega

“mmtmyepplicetim fw‘mequipsmwﬂlmyeminimm
ofetmmrdelivewdehy,
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1820 by the specific components
mutiny:to of the available
it ta e 1710 system. The mimetic»: requests
mm
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W
Mmmmmm.

Attedud are copies of the specificatim far the four mafiatime ma mique pieces of equipnent mammary to magma-at the
IBM 1620
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.

me

fma;t.

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*

aveilebleinW

�Dr. Madman

Secmdly,

Output-er

~2-

May

be grateful if you would review with the
and the offioors‘ of the
Center the
to utilize tha basic 1620 for a minirmn
an

I mid

WW

possibility of

mm

31, 1966

War

Wt

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periodofappmximtnlyarnmdaily.

of April 29, I would be mteful if the facility could
availabla to the EEG pmject prom daily fmm p.111. to

frm
to“
Mt
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is
this prom
ha made

M

and Satmﬁay and Suway

8

mm.

pan. I would

and that the equipmnt which
named under
will be
Center far other users at other times.
available to the

WW
Ibaliawitis
almappmpriamthatmindicateﬂuttmm
will movida the mm). for its
operatimw
prom
during than hours it utilims.
Thank you

for yew assistame .
Sincerely yams,
Max
.

M'Ftkp

cc:

Mr.

1min Samar-tn

Fink, Md).

Professor of Psymiatry

�</text>
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                    <text>ME

'10:

Alfred

M.

m: m Pink,

Mn,

M.D.

M:

HOD.

W

28, 1986

W

vii.

InalettwonﬂnggnberZLDmmmmmpliedm
ammuafm.82up
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mimmidmmumxﬁmdmmtinapmiﬁmtom
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Since Dr. Damn-Gerber indicated &lt;31me to

me

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AcarbmofthiomteisattadudandIfeelsrmldmlybe
communnanm-Garber.
MPﬂcp

cc: Dr. Harold Kaplnn

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                    <text>May

Dr. Alfred

M.

8, 1968

Freedman

Chairman, Department of Psychiatry
New York Medical College
5

Best 102nd Street

New

York,

New

York 10029

Dear Al,
and

Dr. William Karliner is a practicing psychiatrist
in somatic therapies with offices both
specialist and
He has an extensive practice
New York.

in Westchester

at Gracie
He

and has

Square Hospital.

has heard of the reorganization of Grasslands

indicated

facility.

an

interest in participating in that

In the event you decide on the appointment of
an acting director, it might be useful to invite
Dr. Karliner to participate in the planning, development
ﬁe
and administration of a somatic therapy unit. He him
commend
would
and
I
do
so
to
eminently qualified

to you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF:kp

�</text>
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                    <text>Juiy 18.

1968

Dr. Alfred M. Freedman
Chairman of the Department

Department of Psychiatry
York Medics! Coiiege

New

5

East

New

102nd

York,

New

Street

York 10029

Dear A1,
I am pleased to send you this volume
“Antichoiinergic
Drugs” recently puhiished by Elsevier. This
was
heid in 1966 but most of the editing was done symposium
in New York.
My

thanks again

far your support.
Sincerely yours,
Max

Fink, M.0.

Professor of Psychiatry

MF:kp

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                    <text>Jun: 27, 1968
Dr. Alfred M. Freedman
Departnont of Psychiatry
Now York Medical College
5 East 102nd Street ‘
new York. Now York 10029
Door Dr. Froednan:

writing to rocommcnd the nomination of Dr. Charles F.
Stroebel for membership in the APPA.

I

am

I have known of his work sine. 1962 when he came toHe tho
had
Inctituto of Living from the University of Minnesota.
Hillside
boon rccommonded by Gordon Heistad for a position at
Hospital but I could not arrange this, although I wanted to,
since I

knew

I

was leaving.

Dr. Stroebol has done many fine studies in neurOphyaiology,

specifically in the area of diurnal rhythms. He has fine computer
experience and is an excellent statistician.
I would be pleased to have him participate in the meetings

-

A

.

of tho

4-

‘

APPA.

Sinccrely yours,

~1-rr-Iyuorxiu».v.-

Fink, ﬁ.D.
Professor of Psychiatry

Max

Hrzkp

cc:

-

.

.

.
.

.u-E"

31$.

r”:

lnxwgmvk

Dr. Gluock

�</text>
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                    <text>September 3. l968
Dr. Alfred

M.

Freedman, M.D.

Department of Psychiatry

York Medical College
East l02nd Street
New York, New York l0024
New

ma

"hum

W!

n

,

um

'«I'Wg'

";‘~r‘"

‘&lt;._

'v"qvvn&lt;

5

Dear Al,
Thank you for your kind invitation to participate in the
Second Edition of the "Comprehensive Textbook of Psychiatry".
The widespread acceptance of the First Edition assures its

continued success.

It will

be a pleasure to participate again, and I will be
to
provide the section of "computers and psychiatry".
pleased
As you know, I am a protagonist of a more general application
of EEG to psychiatry and perhaps you could consider the inclusion
of some of the recent reviews in either the sections of EEG or
of psychopharmacology.

Sincerely yours,

;
rs

n

Fink, M.D.
Professor of Psychiatry

Max

&lt;165ryﬂ';7llvv

W”

i
.u-rm

Wf‘ﬁ'ﬁs‘.

V

‘

MF:kp

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                    <text>)'~=Wv'1'rl“»’"4

("WY

new,”

7

m.

..

T0:

Dr. A. h. Freedman

FROM:

Dr.

SUBJECT:

Dr. Frederick Beekeland

Max

DATE:

April 23,

1969

Fink

and I have had an opportunity to meet
and
to discuss his proposed program.
Dr. Baekeland
ﬂy

associates

I found him knowledgeable.

experienced but tense and

anxious.
principal interests are in sleep research with
the
manipulations of deprivation of various stages
on
emphasis
and
there effect on mood and effect. He expressed
of sleep
of sleep research except a passing acquaintance
outside
no interest
His

with alcoholism.

principal activities at
in teaching medical students.
His

Downstate Medical Center

is

Impression: Considering the large number of sleep researchers
I am not impressed that he has sufficient novelty in his approach
research.
or enthusiasm to warrant appointment in this area of
I found him to be restricted in his interests and I wouid wish
to inqdire of his superiors at Downstate whether this restriction
does not carry over into his teaching.
MF:kp

�</text>
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                    <text>w

w

:w-—-

(IIIwrﬁwﬁm‘nmwvwvvldnwv—mraa

20, l969

TO:

A. M. Freedman, M.D.

FROM:

Mo

SUBJECT:

Collaborative Project with Dre. C. Miras and C. Stefanie,
University of Athens

DATE:

May

F‘i‘nk' MOD.

'Avgr‘I-WN‘W

mﬂ-‘wmwmwhwpfmwfuir-V'IVW-w-Ir

V‘r—-

w”

-———~w

-nw~w‘

Attached is my report of the facilities at the University of
Athens. These are ideal to answer certain important public health
problems.
Do Chronic marijuana users exhibit a syndrome of
organic mental changes related to this use?

Can a withdrawal

characteristics

What

state

be Induced?
in behavior and in

What
EEG?

are

its

are the physiologic and neurophysiologic
smoking in these subjects?

effects of marijuana

relationships can be defined, and
are these related to differences in response?

What dose

Assuming radioactive THC may be used in man,
what is its distribution and fate in human
tissues, compared to available animal Species?
in View of the active Public Health and Department of Justice interests
in marijuana, it may be appropriate to undertake a pilot study this
summer. Funding for a trial would include:

�.W

rwwhmw-WVWv-u-

-

W‘Plvr»

Dr. Freedman

~2—

Personnel

May

Supplies

U. S.

Psychiatrist

Greek

Psychiatrist

(SIBOOO/yr.)

5

20, i969

Salary

Travel

-

$I000

2,500

Maintenance
$

800

~

—

Laboratory Support
‘

Chemistry ($2000/mo)

$4000

-

—

-

(SiOOO/mo.)

52000

~

—

-

EEG

Travel: Additional for
2 American Supervisors

$2000

Volunteer fees

$l000

Telephong! cable

S

300

$7000

contract request

5

2500

$3000

S

800

be negotiated with the NINH (Dr. Yoiles);
and failing that, the Federal Bureau of Narcotics and Dangerous Drugs, the
Ford Foundation or the Foundation's Fund for Research in Psychiatry. Since
an NiM‘i contract is more likely, i would suggest we call first, then write
to Dr. Yoiios promptly.
Such a

may

This'hontract" is best presented separately from the proposed Kaéler-typo
application, although collaboration with Dr. eras should be included in that
application. This may present special problems and could best be handled
as a separate, concurrent application, possibly even one submitted through
the international Association for Psychiatric Research, which may be more
flexible in its fund management than the College.
Mszp

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                    <text>....

-.».-r

A

«1-

1.“

..

m.

V,

a .

vow". -_-..c_.~m-.w -..t_.,n “mgr-4.11 a...“

-

,

”nu-W v.

.»

,m‘...w_~.\..r“..rr

..

:

w—rq—VlwImr-mrwv1&gt;v—HI"a—Iv‘

-..n.—.., V.”my......,.-.,»n.w~,~r\",v,-

rv—

v-m» '.'~«‘rt

July 9. 1969
”to

Alerd

Now

York Modical Collogo

Ho

ROOM,

H.13-

Profoaaor and Chair-an
nopartoant of Payohiatry
5 Eaat

Now

lOan Stroot

York.

Now

York 10029

Door Al.

It givoa no groat ploaauro to trananit tho oncloood roport
of atudioo cooplotod by our third yoar roaidonta during thoir
oloctivo in Biological Paychiatry. 1968-1969. Dru. Richard
Abrooa, Rohort Lavina and Michoal Taylor hora boon unusually
productivo.
Tho ropOrto rotloct divoroo intoroota. Bra. Taylor and
lovino have collaboratod in atndioa of oar rotio and ochiaophronio.
Ihoir firot roport. "Tho Intoractivo Effooto of Matornal Schiaophronia
and Oliaprins Sax" haa boon publiahod in Science (164: 723-726,
1969), and a aocond. "Pnorporal Schiaophrooia - A Phyaiological
Intoraction borvoan Hothor and rotua" in in proao in Biological

.,

M,

-o

v

A

v

H

R‘:l'-A‘1ﬁ-ﬂf4"ﬁ&lt;(.-"‘

.—

wj-qw

-mrrucwurv

Po chiot . You know that thia work rocoivod ouarda both locally
Nov York lonrological Socioty) and nationally (A.B. lonnott
Clinical scionoo Award of tho Bocioty for Biological Paychiatry).
Tho atudioo hora boon follouod by an additional report on "Tho

Influonoo of tho 8a: of Hoopitoliaod Schiaophronica on Thorapoutic
of Ronroloptica" which haa boon oubnittod to tho
Bullish Jaunnal 0‘ Rsychiattg. Ho hora ainco proparod otudy
protocola to contirn and oxtond thoao chaorvotiona by oooaya
in tho thorapy of achiaophronio.uith penicilloaina and with

Dooogo Loyola

atoroida.

Dr. Abra-a haa collaboratad with anobora of tho ataft in
atudioa of nnilataral convulsivo thorayy, confirming tho difforoncoa
in nooory function and aioilarity in clinical roaponoo to bilatorol
convuloivo thorapy. A opocial loatnra of thia work haa boon tho
dotinition of oaynaatric BEG pottorna which aro rolatod to tho

difforant hohowioral roopanaoa.

'h’u‘h.

�-2-

Dr. Freedaan

July 16, 1969

earlier studies of the California I scale as a
of
therapy choice in mental illnesses , Dr. Levine
predictor
examined the role of socio—psychologic factors in the diagnostic
and therapy practices in our psychiatric service (Effect of
Social Attitude on the Ireatnsnt of Psychiatric Patients).
Based on

also replicated a study of the effects of Cogentin
on both EEG and behavior of psychiatric patients receiving
convulsive therapy, observing that this anticholinergic drug
He

slow wave activity following EC! and elicited
m
the pre-treataent behavioral syndrome, suggesting that cholinergic

reduced the

activity increases during the inter-ictal period of
reported is to be completed.)

301‘.

(This

viable experimental view of the precipitation of anxiety
is encoapassed in the lactate studies of Pitts and Molnre
(New Eng. J. Med” 2778 1329-1336. 1967). Dr. Taylor replicated
their study, verifying that infusions of lactate precipitated
sysptone in anxiety neurotic patients and not in nomls; and that
these precipitated synptoes can be blocked by intravenous calcium
The study was extended to demonstrate EEG changes with lactate
and to pioneer the use of this nodal to define the activity of
new psychoactive anti-anxiety drugs (the Precipitation of Anxiety
Symptom by Lactate Infusions).
A

-

FFH'a-

.
A

g
"qr

-.-—,

"vat-WWW“wammwmrmm-awxm;m-a

These are only a few of the studies that have been done.
Dr. Taylor with Dre. Spero and Sisson also coupletsd a review
of the clinical effects of chlordiasepoaids in our clinic,
suggesting that adaptation (tolerance) does develop with this

drug.

“I“

(CUMe "imp. Rue, ,139‘1‘,
“.3
mush“
Abrams also completed "A Manual of Convnlsive Therapy"

ha.

1969). Dr.
which described the
and

varieties of techniques for inducing seisnres
is being distributed to residency training programs in

various psychiatric centers.

year has been productive. challenging and stimulating
and ny associates join no in expressing our appreciation for
this opportunity to participate in the training program.
The

Sincerely yours .
a,"

._,,,‘

‘
_,.~

4.,

.lwmwfwaﬂﬂm'rr

Fink, um.
Professor of Psychiatry

Mar
M! :kp

-

�</text>
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                  <elementText elementTextId="105773">
                    <text>To:

Alfred

980%:

Max

SUBJECT:

Description of the

The

M.

Fink,

Frocdman, M.D.

DATE:

Gctober 17, 1969

H.D.

York Hodlcal Colloge-Mbtropolltan Hospital
Addiction Pregrams. as requested by Mr. C. a. King, 10/14/69.
Now

addiction treatmmnt and rosuarch programs at Metropolitan

Hospital have teen in operation since 1966.

Many modcs

of therapy

have been assassad, and the most successful has been the “pharmacologlc

rehabilitation“ approach.
substances that

In

thtse, the subjects art treated with

telltva opiate

hunger or prevent opiate dependence,

and are concurrantly continutd in an

intensivc aftercare system

to assist the davelopment of thair educational, family and job
potentials. The engagement of the subjoct by the gharmacologic.
approach has lmprcved the success of the

rehabilitation tachnlqua

alone.
Qua problem has bean

and

this is

to

dav310p morn

a goal of our programs.

we

affective antagonists

have studied mtthadone,

tybasatc, cyclazocine

and naloxone - and now contraphenaxina -

to datarnine the best

method

ané

turatlon of action.

To

of administration, their safety,
assess their efficacy,

we

havc

JaveIOpad and are the principal proponents of 'hcroin challengas'
as a tool of research and of therapy.
The present emphasis

delivery of naloxono

and

is

of

have shown tho most promise.

on

the devalopmont of improved

methadone - tho two compounds which

�7

r.

“WV—w

n.q,.... "L..._._w,...._.,».~.—. ,1 Wyn -m»—._w.n~,wm-m—uw ,,V. W

The work was dono

for

many

but since January 1969 has boon

up

.
.
M...

ﬂ...

_

out’pationt facilities

linitntions,

no have

your:

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,

v—

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floor.

15A

Bocausc of

restricteé the in-pntiont

staff

program

20-22 beds; but expanded the outwpationt progrsm

subjects.

The duration of

may-w

and the

”.mw’nwvmvmnv

60~80

v—v

on words 123 and 15A

restricted to

on the 15th

-.—

to

to includo

in-pntiont care is

1-3 months;

szv

w—u

"tw

out-patient, indefinito.

We

are

now

trying to

wean a fow

qt”

Jamar-"m?“

”v.-

pationts
we

who

have boon with u: morn than

3

years.

To do so

are dovoloping a special combinod drug therapy which

toquires

some

nursing cooperation as well as medical supervision.

our program admit: approximately one patient each day, and
has a waiting
The

list

principal

l.

of 60-100 at any time.
forms of therapy and a comoon sequence

is:

withdrawal and detoxification using

decreasing amounts of methadone;
2.

Social service evaluation; group therapy;

3.

Educational evaluation and introduction to

v

retraining;

-,-

r
"rur‘

-—

Wm

n
&lt;

wresaswv"

4.

Medical evaluation and therapy of medical conditions;

5.

Induction

on

antagonists (metﬁaéono, cyclazocine,

naloxono);

navy-tau-

6. Heroin challenges;
7.

Aftorcaro, with the appropriate thoropy: rehabilitation,
group therapy, social casework, and

phornacological monitoring.

�1

ml

“7".“ ,__ ,y-uv— m-w my"-

vuwwl'ﬂ-ivrrwvwx

_‘

"u:r.v'T“'!‘--v-errl"

-—:——mw~;—-_

——-m‘

-

._————-

1.....—

Wﬂvw—mu—

In response to suggestions for the immediate future,
I would emphasize

that

no therapy has been

tested to warrant general

and

sufficiently

indiscriminate application.

despite the severity of the problem.

The dengere

of each

approach are poorly understood and any mandatory program

(especially

if

carrieé out

lalty) will provide

by untrained

the basis for more harm than good.

Efforts at developing better pﬁermeeologic agents,
the trial of storefront. non-hoepitalcentered units for
delivery of antagonists, special oducetionel unite in the
especlally 1n the schools and the health centers
to involve the users in the treatmont programs, and better
community,

general medical care of the addicted are

that are logical

now.

A

of the steps

broad scale methadone-rehabilitation

program should be available to

project

some

all

who

volunteer.

One

would be the development of a long-acting neloxone.

ee potentially the most useful pharmacologic tool at
From

the point of

View

of the report,

we

would

be labelled as:

Experimental-research:

60%

Care and therepy:

40%

Fink, M.D.
Professor of Psychiatry

Mex

MP:kp

specific

this time.
best

�</text>
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                    <text>”was

(0,)»

.v

,r

”or,"

"*y-

v."

o,

-m-

December 18, 1969
Dr. Alfred Freedman

Department of Psychiatry
York Medical College

New

5

East

New

102nd

York,

New

Street

York 10029

Dear A1,
I have just completed two sessions with the second year
medical students in a laboratory demonstration in psychopharmacology. The students were cooperative and the demonstration
was successful in eliciting the powerful effects of set and
expectation on the evaluation of drug effects.
The schedule allowed time for discussion and in an open
inquiry period, I became concerned that the students who did
express themselves, indicated attitudes that are inconsistent

with human

clinical psychoPharmacology, as I View it. They
modern drugs were ineffective, or effective

suggested that

only as placebos;

the dosage ranges they discussed were subthreshold

for the mentally ill in our institution; and there was
emphasis on the toxic effects of psychoactive drugs.

an

inordinate

of these attitudes may be derived from their present
lecturers, most, if not all, being animal pharmacologists with
limited clinical experience. I am reviewing training programs
in psychopharmacology for the ACE? meeting in February, and
as I review our programs. both undergraduate and graduate, I
wonder if a more clinical, or clinical—experimental View could
not be provided.
Some

git),

best

e

Sincerely yours,

Professor of Psychiatry
HF :kp

�-~

'Mwuwut-Ivmwuvr

.

‘um‘ \-.-...--.-v,~-,.V-‘.-.w.wnu-—.— —-—mv-,..~r.~.....--

my.

w

v

.

. .

i

V,

V.”

. “MWW.

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_

..

5...

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.

,

a; «WV... ".7 .

ﬂecember 18,'1969
Dr. Alfred Freedman

York Medical College

New

Department of Psychiatry
5 East 102nd Street
New York, New York 10029
Dear Al,
I would

like to

recommend Dr. Alex Karczmar

for your

consideration for an appointment in the Department, as an
experimental pharmacologist, for the research units at the
New Community Mental Health Center.
His curriculum vitae
and publication lists are attached.
I know him principally from his participation at the
and CINP meetings. He is a valuable and expressive
speaker, and has a good grasp of experimental psychopharmacology.
He seems to relate well to clinicians, and I have found him cooperative and interested in the same subjects that interest me,
ACNP

particularly cholinergic aspects of behavior.
While it may be premature to nominate candidates for the
laboratories, I am aware that it takes up to 2 years to separate
a good candidate. Alex has expressed an interest in an opportunity
in

New

York.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF2kp

enc.

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                    <text>wry-avF'r‘rv‘w—W

‘4‘w-"m‘

~x'--‘

Hummer-m4“

way. u-

.

.11.

w y vw.‘

r q-«nwm-y-W-xwumuu-w~-~—v.(.-ym-M‘wa

aw" u.- -N—v V.....,.-,

»

,l

7-.-

“w

‘

a...

w

.

n...

.‘._

m.

w

w“ Wm...’ a.

.7".

WV

November 13, 1969

Dr. Alfrod

M.

Freedman

ﬂepartmont of Psychiatry
New York ﬂedical College
New

York,

New

York

Dear A1,
In making the arrangements

for the president's reception

are faced with certain decisions and I would like your
judgment.

we

A cash bar will require eaoh guest to pay $1.65/drink.
Our charge would be $35 for each bartender and I am requesting
two bartenders be available.

-

mwwmrv-yr

l
‘

:u'v’w

Canapos may be purchased in one of two ways - a fixed fee
of $6,50 per person for a two hour cocktail party; or our
purchasing a quantity of food that we think is adequate at
varying costs per tray. A cepy of their costs is enclosed.
The management suggests sixteen pieces per person as a reasonable
average, especially at that time of day and EOr a two hour period.
I am unsure as to the number of people who might attond
but estimate 80 to 100. If we accept the number of 1500 pieces
and use the minimum costs, I come to $700a$800.

If we take a fixed cost per person we are than dependent on
the management providing enough food. If we do it by the tray,
I believe I can request the managmenot to deliver more trays
within a short while if the demand requires. I would like
to request a variety of hers d'oouvres initially on the basis
of 1200 pieces (12 piocos/person) with the proviso that we
order more as nocessaxy (and funds allow).
Sincerely yours,
Fink, M.9.
Professor of Psychiatry
Socretary

Max

MF:kp

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                    <text>3=/
T0:

Alfred

FROM:

Max

SUBJECT:

Zelson Proposal

M.

Fink,

Freedman, M.D.

‘

DATE:

November 7, 1969

M.D.

I have read the proposal and can understand the Review
Committee's comments. The proposal is unfocussed; the ideas
too general; and dependence on outsiders to do ”their thing”
prominent. The staff has experience with opiate dependent
mothers and infants and the proposal appears to have been
formed by the buckshot method - try everything that sounds

sood.

is to help them. The focus is
therapy but on diffuse biochemical effects in infants.
Why these tests were selected is not clear.
Perhaps they
should be encouraged to focus their interest, explain their
foci, and this would be useful in defining a new protocol.

not
warm

my;

1‘1:qu

I

on

-‘"‘NI“§"7-qw

recent relevant publication

most

Mr. Rich

and

&lt;.

(
'w

4mmv—W1-u-r

‘

Jpnﬂi'ﬁm};

Mszp

...).

his

is the statistician of the Department of Pediatrics

is held in

"um"

vwwm».

1930 and lists as
1957 (1952, 1948

Asides: Dr. Zelson graduated in

“awfuyam

.

do not know how one

good

repute by

Don.

�</text>
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                    <text>January 22,
Dr. Alfred

M.

1970

Freedman

Department of Psychiatry
Now York Medical College
5 East IOan Streot
New

York, New York 10029

Dear A1,

its

The Research Committee at
meeting today was unwilling
an alternate for my membership on the
committee. I withdraw the suggestion.

to accopt the concept of
I

find that

I am unable

to attend the meetings of the

ResoarCh Committee with sufficient frequency to be a useful
participant and ask your permission to resign.
I would commend Dr. Stanley Foldstein, Associate Professor
of Psychiatry, to your attention as a suitable substitute.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

”szp
cc: Dr. Lohr

�</text>
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                    <text>-.-uﬂ

TO:

Alfred

FROM:

Max

M.

Freedman, M.0.

February 4, l970

DATE:

Fink, M.8.

SUBJECT:

Attendance at Executive Faculty Meeting

The

principal issue at the Executive Faculty

change in curriculum

third
Dr.

was the

increasing weeks for medicine in the

—

and fourth year and decreasing psychiatry and surgery.

Jaffe indicated that psychiatry

in a gentlemanly fashion.

great concern that this

The

had accepted the decrease

surgical representatives voiced

recommendation would be

disastrous

to the surgery training program.

It

that

was my impression

Dr.

Jaffe's report

was poorly

described with inadequate support of the numbers in the proposal.
He

was unprepared and

had many

errors in

On

a vote

On

a vote

insisted that the report submitted (appended)

it.

to table,

W

I

abstained.

to accept the report,

I voted

The/yote was not accepted l3 to 12.

MF:kp

against acceptance.

�</text>
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                    <text>TO:

Alfred

FROM:

Max

SUBJECT:

Fellowship Status, Dr. Jan v. Volavka

M.

Freedman, M.D.

DATE:

April 9,

1970

Fink, u.n.

Dr. Volavke requires two years training credit to achieve
entrance to the New York State licensing examination. One year
may be in psydhiatry, and the second in another clinical discipline,
3.5;, medicine, neurology or pediatrics.

For

this year he requests

an

accredited program in psychiatry.

Following our discussions, I suggest the following curriculum
which, if satisfactorily completed, should meet our ”training”

requirements.
1.

2.

3.

Course work - any of the following:
(a)

Introduction to Psychoanalytic Techniques.

(b)

Principles

(c)

Continuous Case Conf. in Group Psychotherapy.

Clinical Supervision

ﬁr. Wolherg

and Techniques of Group Supervision.

~

Dr.

c. welter-

Dr. E. Fried

Either of the following:

(a)

Individual psychotherapy,

(b)

Group psychotherapy

by Dr. Negler (and
Dr. Sadock (and

~ 1

2

cases, supervised

staff).

group, supervised by

staff).

Clinical Service.

Case management and responsibility for patients in one
of the following projects of the Division of Biological Psychiatry.

(a)

Comparison of

(b)

Anti-narcotic activity of

(c)

Child Psychopharmacology program

anti-depressants in
PCPA

subjects - Pink, Zaks.

PHP

- Finger. Simeon

in opiate dependent
~

Simeon, LaVietes

If these suggestions meet with your approval, I will try to negotiate
the details with the supervisors and clinics involved. I prOpose Dr. Volavka
be given credit for an academic year, 1970.
MP

:kp

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                    <text>%

%

i

5

‘

§

5

TO:

A. M. Freedman, M.D.

FR M:

Max

SUBJECT:

Child Psychopharmacology Project

Attached

is

Fink,

a
PsyChopharmacology

DATE:

Outober 26, 1970

M.D.

report on the first year of the Child
Project.
patients in active treatment now, treated

There are 11
by
Drs. Robson and Caztanaga, Miss Formicelli, H.S.w. and Mrs. Korein, M.S.W.
and Boone Durbin, R.N.

I antacipate difficulties in maintaining this special unit
without a replacement for Joven Simeon. In View of the need for
additional staff in other programs, I will recommend discontinuation
of this special project. Dr. Gaztanaga and Miss Durhin will continue
in the adult program; Miss Formicelli and Mrs. Korein reassigned to
the narcotic addiction unit; and Dr. Hobson should be re~assigned
to Child Psychiatry, full time - with reassignment of her salary
from 47—072—5 (narcotic addiction) to child psychiatry or other
departmental funds.
MF:kt

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                    <text>To:

A. M. Freedman, M.D.

FROM:

Max

Fink.

DATE:

January 25, 1971

M.D.

Mandatory Consultations

SUBJECT:

I can

think of so few medical situations that require a mandatory

psychiatric consultation that I hesitate to list even these. Rather
than subscribe to such a limited list, I would suggest a concept of
recommended consultations in the following instances.

states, particularly post-partum.

(1)

Withdrawal and depressed

(2)

Addiction syndromes, as in

post-surgery or postutrauma.
where a

threat to life is seen.

barbiturates, alcohol

and

opiates.

requiring restraints.

(3)

Toxicomania

(4)

Recurrent surgery without adequate oathology; and other states

—

as "hypochondrtasis" or

any severe delirium

”hysteria”.

Whenever the secondary diagnosis is depressive illness.
schizophrenia or severe psychoneurosis, and these diagnoses may
reflect contributions to the primary iliness or to its management.
15)

MF:kt

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                    <text>an..."

TO:

A. M. Freedman, M.D.

FROM:

Max

DATE:

January 25, l97l

.-..

A—r.vn.-.vn~—&lt;,w-.'.,.,-..r,

Fink,

M.D.

Mandatory Consultations

SUBJECT:

w-K
n

,-v~.-—.—‘—.lw-

.n'

.7:

~

think of so few medical situations that require a mandatory
psychiatric consultation that I hesitate to list even these. Rather
than subscribe to such a limited list, I would suggest a concept of
recommended consultations in the following instances.
I can

(1)

Withdrawal and depressed

post-surgery or postutrauma.
(2)

where a

(3)

states, particularly post-partum.

Addiction syndromes, as in

threat to life is seen.

barbiturates, alcohol

Toxicomania - any severe delirium

and

opiates,

requiring restraints.

(4) Recurrent surgery without adequate pathology; and other
as ”hypochondrlasis“ or ”hysteria".
[5) Whenever the secondary diagnosis is depressive illness,
schizophrenia or severe psychoneurosis, and these diagnoses may
reflect contributions to the primary illness or to its management.
MFtkt

states

�</text>
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                    <text>February 26, 1971
A. M. Freedman, M.D.

TO:
FROM:

Max

Fink,

m.

Chapter in Textbook, Tranquillizers in Psychiatry

SUBJECT:

it

I have read the chapter (35.1) as you suggested, and find
quite good and up~to~date. It is easy to disagree with some opinions;
to suggest that the emphasis be changed, but any criticism would be
minor compared to the major areas of agreement.
be

80%

If you

wish

this rewritten,

very similar to Denber's

less chemical,

I can do

article,

more neuroPhysiological.

it.

The

result will

but the emphasis will be

are correct in assessing an absence of data on lithium
Kalinowsky's section on miscellaneous therapy is weak.

You

therapy.

My principal hesitation is the personal
conflict with Hy. Please assess the risks and
to the gains, and make your decision.
Mszt

one of coming
damage

into

in relation

�</text>
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                  <elementText elementTextId="106264">
                    <text>--.

rwmwa—w—n-

*M'wmﬂ‘ﬁm'e—WV'W‘WI

--

~

-

m.»-

.

r

,

Hal" W‘W"1wwn-".Vr’T-wwwvv——w&lt;

v—w'wm—WNﬁI—ﬁmmv—Hmm—IIV

..

whfwrw...

7

..._—...~

.w—m

‘—,‘

‘

we”..—

A

“WT—.mwwm-

-

~

“

June 11, 1971
w

-v‘r&gt;wwww'yww-w

Dr. Alfred M. Freedman
Chairman and Professor

Department of Psychiatry

.,

New York Medical College
5 East 102nd Street
thew York, New York 10029

~

nmw..—.

Dear A1,

.«mn—

.
V,

r
.7

V

I

.

ww'mvwwW-V'N—W

‘

s

wlmwmxwmwzrw“

For the past two years I have tried to find the time to carry
out my research and clinical committmants, serve the changing needs
of the Department, particularly in opiate dependence, to write the
henﬁsarticlea of the Division, and to write the books I would like
to write ~ on EEG and drugs, on the narcotic antagonists. and on ECT.
With the new services at Kirby and perhaps at.Mbntrose, I fear I will
not make any progress in summarizing my data.

I am writing to request a sabbatical year effective July 1. 1972.
I joined the Department in April 1966 and believe I will be eligible
at that time.
Such freedom will allow me to join the faculty of a university
center or research laboratory in Europe, where the reports could be
written (I hope) and I could learn more about psychopharmacology and
electrOphysiology. To make the necessary arrangements I will need
the school's approval now. 'This will permit me to make my connittments.
to work through our programs so they may be productive in my absence,
and to plan adequate coverage for my programs. I believe my staff is
adequate to maintain our programs without significant interruption.
Many

thanks.
Sincerely yours,

WW

wwr-wm—r

Max
wwmw

MF:kt
'Ta—n

n...

———.—~—v—Ww

Fink, M.D.

Professor of Psychiatry

‘

�</text>
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                    <text>To:

I.

A.

H.

?ROM:

Freedman, H.D.

Fink,

DATEr

Mby

17, 1971

M.D.

Proposals for Developing a LonguActing Narcotic Antagonist

SUBJECT:

Establishment of a research center with its own staff.
Since the leadership is in the nepsrtment of Psychiatry, such a
center can be seen as part of a large program in drug dependence,
based at the new Mental Health Center. Since the Center has 3
floors of laboratories, and 250 patient beds (29 already dedicated
to addiction on the 6th floor), it is a logical center for such
1.

research.

will need funds to equip the laboratories, appoint
chemists, pharmacologiats and pharmaceutical specialists, particularly
The program

those interested in addictions.

For equipment (assuming space be made availabe at the
estimating 1/2 the 3 floors.
$850,000
For personnel

Scientists

(lst year)
$35,000
staff

6 9

@
Supporting
each
$50,000

Clerical

MEG.

and

210,000
300,000

“econ-

550,000

__

‘UWWWW‘Vq—‘W’w

,

Supplies

40,00n

Consultants

20,000

The annual budget in years 3~10 should average $750,000, to be
supplemented by special project grunts as may be needed.

�.

—m=

For Consulting contracts to develop a silaatic vehicle,
e.g., Food &amp; Drug Research, Inc.
$70,000
80,000

1970~71
1971—72

‘80,000

1972-73

$230,000

For consulting contract, to develop physiological slow
release method based on non~silastic model.
e.g., Alza Corp.
$300,000
300,000

1971—72

1972*73

$600,000
For consulting contract, based on oil depot preparation
e.g., Dr. Pilpel, Chelsea College, England’
1971«72
1972~73

3

50,000

m_50,000

$100,000
To

develop alternate antagonists
(a) M~5050_Rcckitt

&amp;

Colman

www.crw

wv/

w

l.

Aiimal Toxicology §_l§J000

2.

Intral

w,

“7—,

Dose

Toxicology in

man

$90,000
wmmrww,

39

(b)

trials

year $70,000—100,000

15319.29:
WEN

1.
2.

assay,
dose finding
Supplies of drug

3.

Human

P‘mww‘w’wrm—W"

.r.

Long term
1

.

.iwvwwww

16,000

Supplies of drug20,000
Personnel
__70,000

"v

A-w

$

Human

clinical

trial

$

50,000
50,000

70,000/yr.

�</text>
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                    <text>mn.W—mw~—wr

,

TO:

Alfred

M.

Freodnln,

FROH: Max

Fink, H.D.

SUBJECT:

Dr.

lain

.

,

M.D.

DATE:

May

., Ww.w

.n-

17, 1971

Khazan

Dr. N. Khazan, Associate Professor of Pharmacology
Mt. Sinai School of Hodicino, has exprosscd an interest

our faculty.

I have

“mm..-

at the

in joining

of his work in addiction for a few years. Earlier
roferred to us for our ability to analyze his EEG
tapes. Rb have had an interesting working relationship, and I
bocame aware that he is studying opiates, antagonists, and cannabis.
His work is complementary to our own.

this year

known

ho was

vitae is attached. I would
attention, for possible referral to Dr. Lehr.
His curriculum

MF:kt

commend

him to your

uunu...

mxwr-va-m—u-

~

�</text>
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                    <text>v:

x

r
4

a.

,«Aymr

:v
1.v

.uwwww

July 22, 1971

awnwuzzggauuu

Prof. Alfred
-»a1¢uuwrgnzm«

u?

Chairman

M.

Freedman

Department of Psychiatry
New York Medical College

«tr:

4-14.”

Dear Al,

Re: Rhea Dornbush, Ph.D.

n-.~_.menw-re

.vm

«

raw/«mt

«truism

erﬂ'ﬁmiwﬂ‘r

3:

Dr. Rhea Dornbush has done an exemplary job in all
her assignments during her tenure in the Department since
1968, that I am pleased to recommend her promotion to
AAAou'au Paaﬁuzs M.

Since joining our faculty in 1968, she has described
the memory effects of unilateral and bilateral electroconvulsive
therapy; the effects of acute cannabis inhalation on mood and
performance tasks; developed the chronic cannabis study
program, assuming all the responsibility initially assumed
by Prof. Stanley Feldstein; and has established the liaison
with some of our overseas collaborators.

I have found her knowledgeable, responsive, responsible,
excellent co—worker, and recommend her promotion
without reservation.
and an

0.

:

Sincerely yours,

-;

«tw-vv.»

r
r"

Max

WSWVK~

Fink, M.D.

Professor

m.

"HF,

Director, Div. Biological
Psychiatry

mf/

�</text>
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                    <text>v--,-—.‘ «v—

,.mmm

__

._...

“.mm.

OcTober l0, 197|
Dear Al,
i

should like To recommend Richard Abrams for

membership in The formulary commlTTee of MeTropoliTan HosplTal.

years ago, aT your requesT nominaTed Richard
Resnick; and iaTer, asked Mrs. Cruzado To lnviTe me To dome
Some

I

I

of The meeTings.

These are held aT irregular lnTervals, buT The
is responsible foo The assay and deTermlnaTlon
of Those psychpharmaceuTicais ThaT are To be included in The
formulary, eiTher on a perminenT or Temportry basis.
CommiTTee

i

believe

ThaT Dick Abrams

is well qualified for

This posiTlon and considering The years ThaT Dick Resnick has
served, lT would be To every one's advanTage To make This requesT.
Thanks.

Max

Fink,

M.D.

�</text>
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                    <text>OcTober 9, l97|

Prof. Alfred M. Freedman
Chairman, DeparTmenT of PsychlaTry
New York Medical College
Dear Al:
The following noTes are wriTTen in response To your
informaTion
for
as To my relaTionship wiTh L. Bucci, M.D.
requesT
l
firsT meT Luigi when
T0 The DeparTmenT, and his inTeresT
me To requesT his appoinTmenT To my

he applied for an appolnTmenT
in psychoTropic drugs allowed

division.

His firsT assignmenT was an evaluaTion of The
duraTion and poTency of fluphenazine enanThaTe compared wiTh
oral fluphenazine; and This laTer was augmenTed by a comparison
wiTh fluphenazine decanoaTe. As is our cusTom, we esTablished
a proTocoi for The admission of paTlenTs To The program, Their
supervision and raTings, and The Types of evaluaTions required. MosT
criTical in such evaluaTions, is The adminisTraTion of The
proposed dosages for The proposed lengThs of Time, wiTh The
physician allowed To use his judgmenT in each case as To The
From The very ouTseT, Luigi had
proper dosage To be deployed.
more difficulTy Than Two oTher TherapisTs (Maria Fuchs and Jovan
Simeon) in carrying ouT The proTocol. The dosages were more
variable Than ThaT of The oTher physicians; There were repeaTed
supplemenTaTions wiTh oTher drugs, parTicularly MAO inhibiTors
(despiTe proscripTion in The proTocol); and The records were mainTained in an idiosyncraTic meThod.
aT

LaboraTory TesTs were noT requesTed as required, and
various Times, The duraTion of TreaTmenT was suffciienle

aiTered ThaT The drug Trial Took
anTicipaTed.

many more monThs Than we had

AT The end of The experimenT, we noTed ThaT The
evaluaTion of secondary effecTs for Dr. Bucci's paTlenTs was aT
IeasT Two Times ThaT of The oTher physicians. On examining The

records and The available cases, we noTed a marked discrepancy
beTween The evaluaTion criTeria he used, and Those of The resT of
The sTaff. AfTer considerable review, l concluded ThaT The idiosyncraTic naTure of his judgmenTs was sufficienle differenT Than

�"nv -vw,mw&gt;n~ m-w—I—H—o-w

my

experience

To

‘iw_mwww.’.

--

mm w.wmmwwwvww i,”
TVWV

preclude his usefulness in

of The Division of Biological PsychlaTry.

The

ﬂ_»_r..i.,.._..........-.wv-

research programs

His opinions wiTh regard To The TreaTmenT of
MAO inhibiTors are based on sTudies which
he has published. i have read Two of These reporTs, and recall
ThaT They failed To saTisfy my criTeria for an academic reporT—They were deficienT boTh in conTrols and in independenT evaluaTlons.

psychoTic paTlenTs wiTh

In adleion, i am aTTaching a xerox c0py of a reporT
which he published from The work aT MeTropoiiytn HospiTai. i
do noT recall seeing The proTocoi filed or approved, and I
suspecT ThaT This sTudy was done conTrary To The rules of
The school. This, despiTe, my urging him To file The becessary
documenTs before a sTudy is conTemplaTed, parTicularly one
ThaT is as unique as This one.
On

The posiTive

side,

i

would

recall

To

your aTTenTion

his enThusiasm for Teaching and parTlculariy his drive To
asserT The posiTion of psychopharmacoiogisT To The DepaTmenT.
There was a disTincT dissoclaTion beTween his enThusiasm and his
abiiiTy, and for This reason, i requesTed his Transfer from The
research divisions and failed To supporT his requesT for
promoTion.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychlaTry

-

�</text>
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                    <text>III-1“

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
70:

Alfred

FROM:

Max

M.

Fink,

The

Freedman, M.D.

DAT;

M.D.

SUBJECT

August 11171972

Attached

attached proposal for a joint study between Dr. Inturrisi and

Dr. Levine

is

a valuable addition to our on-going

studies of

levo—

methadyl.
This information
an

information

is sent to

you

for your files,

and

to suggest that

letter regarding the collaborative study

appropriate College authorities.

be sent the

�</text>
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                    <text>F:

W

October 22, 1972
TO:

Alfred Freedman,

From:

Max

Subject:

Request of Pennsylvania Medical Society regarding
002 THerapy for Opiate Dependence

M.D.

Fink, M.D.

I have read the submission of the protocol (which is
letter of transmittal, and testimonials by Dr. LaVerne.

incomplete),

Except Gﬁr the testimonials and the alleged private practice
documents are devoid of the type of information required
to assess the usefulness of the therapeutic studies. The program
lacks a theoretic basis, and except for the spurious association
between the availability of the technique and the availability of
the patients in the same office, there is no justification or

data, the

basis for the application of the inhalations in drug addiction.

Since the Pennsylvania Medical Society has already
presented the information to a most sophisticated panel (Drs. Brill,
Seevers, and Primm), it seems an unnecessary duplication of effort
for this unit to attempt an evaluation of the data submitted.
Considering the possibility of undertaking an evaluation
of 002 therapy at the New York Medical College, I would not recommend
such a course at this time: there is no basis for the study; the
risks are great; and prior committments preclude the use of our
limited facilities at this time.
As a political eXpedient, referral of this agency to
could occupy some of their time
would serve two purposes:
and effort; and if the project has merit, they have the funds and
SAODAP

it

the connections to establish the studies in the national

interest.

mv

�</text>
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w-uwu—MTINaran—wmwpw—nu—

-

~

u

,A

-...

cam-m

4“,..."

”7“. “JV“, .7 ,or,

.1....,..,W.,....,,,, w"
v

.m-v

r

..

..,.

.

-..... ,

n.7,," ‘r 17...“.

..&lt;..

.... , V......v.,._..o..r ,.

._n

73sn~76083
1a Rovonbor 1973

Charla; 0. Rutlodga. Ph.D.
Dopartnont of Yharnnoology
Univotolty of Colorado School of auditing
4300 East 9th Avenue
Denver. Colorado 80220
Boar Dr. Rutlndzo:

I ll planned to submit this letter of recommendation on
bdhalt of Carolyn V. Poiolor. who has worked with on since
Juno. 1972, following her graduation tron Colby Coll-go.
graduated with I major in biology and did eopc~
oially wall. but aha also to on without I specific toouo of
interest. This laboratory is dodtootod to the analysis of
tho changes produoud In tho scalp EEG of man by prolunod and
actlvl poyohonotivn agents. Th. facilition include Grass
polygraphs. FM tap. roootdoro. and a dodicotod IBM 1800 con—
onto: for data rcduction. Hi work with voluntonr waist to
ﬁxtondod obocrvatlon aoaoions.
Candy

Candy

has learnod

how

to interview voluotcoro. obtain a

analyst this quantitativoly aging all of the dot:
tuduction oqulpnont, and to nuunarlso and «walnuts tho data.
In addition to £36, oh. has loornod how to obtain Ilood can»
plan. take blood pressure. ond-noot 1mportant-to maintain
a profounionol attitude with subjects which inaptroo oonfidanco
and their cooperation dospito aioconfort.
fine

EEG,

This work has boon going on in my liberatory since 1959,
and Candy has been one of tho two most outstanding students
thnt I have had. Sho has always mnintalnad hot point, is moot
plea-oat to work with, is enthusiastic and completely roliablo.
.A

,

.
u:

'mm-‘m‘wwbmaruﬂr'fﬁ‘ﬂv

.;;.

Now—r

..

1

�mW—wwmw-Wﬁ.w.n‘wp.ww_.

Dr.

c. 0. Rutloégg

7w w mu“,-

-2-

,, ......,.. ..,.._._

,_

_

WW aw.

.

7—

._._ m. ,_»

V

7.

a... ..

16 Novonbor 1973

Horn 1: not for the fact
on to graduate eduottion.

that I onoourago my antistnnts to
I would rcgrot bar dociuion to
but
I
loava.
an gratifiné that the has seloccod n fins ins
stituuion in which to continua hot graduato studies.

I In ploasod to raconnnnﬂ bar without roaorvation for

go

you: graduate study program and hi»! assurod her tho: I would
b. dolishtod to havo hot toturn to work with no at any ttno.
Sincerely youru.
ﬂax Fink. M.D.

Professo: of Psychiatry

MF/oin

Encl.

�</text>
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                    <text>4-4 - v-r-.—-

... we»

yrs

~

',w":»“ xv»-

2‘

an" «nary-w

umwﬁﬂmwxmmn:

'
V
av. we-mxn-p.»...

m

,

.

'

_

,,

.

,

.

turr-

mun- we— ,7

,

”new: AM)». wranwm

a“,
a«ww—nvv~;.~~w-W»-wmqgm.

"
'-

-

W'v.ﬁr—"~Vwﬂn‘l&lt;mﬂw“

August 11, 1976

Alfred

New
New

M.

Freedman, M.D.

York Medical College

York City

Dear Al,

I have just read the report by J. Fishman, "Preparation
and Evaluation of a Sustained Naloxone Delivery System in Rats" which
appeared in the journal Pharmacology 13:513~519, 1975. It is excellent
and suggests that a long acting formulation of naloxone is feasible.

I

commend

the

article to

you.

have sold the house in Setauket and returned from a
trip through Great Britain (for a nation with such beautiful
countryside and and exciting heritage, why can they not learn to
cook food tastefully ? ?).
We're busy with college preparations for
the last of my children and anticipate with some optimism the next year
We

long

at

SUNY.

My

regards to Marcia and Irv.
Sincerely yours,
Max

Fink,

M.D.

-,,1-

1w“.—

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                    <text>May

19, 1978

Alfred
New
New

M. Freedman, H.D.
York Medical College
York City

Dear Al,

I

trust the

food and wine.

meetings in Paris were as good as the

While you were away. Dr. Tai (? sp) called from Stamfbrd
with
an interesting question. What criteria should be
Hospital
who on the staff is accredited to administer
decide
applied to
ECT ? The same question was asked a few weeks earlier by the
physitian in charge of New Rochelle Hospital.
The Task Force report does not make a specific recommendation.
consider a request to the American Board of Psychiatry
did
but
and Neurology to establish accreditation criteria. As I recall the
discussion (as told by Fred Frankel) of the first Trustee review,
we

this item

deleted.

was

personal suggestions to Dr. Tai, indicating
standards of accreditation that were applied at his
hospital for physicians carrying out similar difficult skills in
treatments that carried similar risks (e.g., anesthesia, surgery)
should be applied for physicians requesting approval for BOT:
evidence of preceptorship, a number of treatments,given under his
control, knowledge of the principles of BCT, and skills at treating
Since criteria of this kind have
the emergincies of the treatment.
not been applied heretofore, I suggested he may want the umbrella of
your Departmental recommendation. If he should get in touch with
you, this note will explain the basis for his seemingly odd request.

that the

I

made some

same

My

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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Health Sciences Center
State University of New York at Stony Brook
Stony Brook, New York 11794-8101
telephone: (516) 444-2990

’—

StonyBrook

/

ﬂ

2

September 30, 1985
Alfred M. Freedman, M.D.
Department of Psychiatry
New York Medical College
Valhalla, New York 10595
Dear Al,
Thank you for your kind invitation to join the distinguished Board of
Editors of Integrative Psychiatry. I am pleased to accept your invitation, and look
forward to supporting the aims of the journal.
My

best regards.
Since ly yours,

/

Max ' ,M.D.
P essor of Psychiatry

�</text>
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                    <text>May 23, 1987

Alfred M. Freedman, M.D.

IPMS

Department of Psychiatry
New York Medical College

Valhalla, New York 10595
Dear Al,

am unclear about the mission of the new International Association
for the integration of Psychiatry and the Medical Sciences (IPMS), I am pleased to
work with you on this project.
While

1

In the latest number of CONVULSIVE THERAPY, I have written an
editorial about the increasing interest by neurologists in behavior and of
psychiatrists in brain function, with the re-emergence of neuropsychiatry (under
the code-name of Behavioral Neurology). Indeed, it was only yesterday that 1
proposed the development of such a journal to Alan Edelson at Raven Press and
recommended that he consider inviting Michael Taylor to develop such a project.
‘

Perhaps we are responding to similar awarenesses, with a slightly different
emphasis.
in any case, I look forward to hearing more about the forthcoming meeting
in New York of IPMA.
‘

My best regards.

Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>“'r'wwn'w" MF’ WW~w——,nu

-..v

v

~

,

IF:

,

v—w

rmw—mwuuf

-

-—m-wm"l‘v-—lwv-L’-‘V"V.

May 30, 1988

Alfred M. Freedman, MD.
Professor 5: Chairman
Department of Psychiatry
New York Medical College
Valhalla, New York 10595
Dear Al,
Enclosed is a copy of your nomination for the 1988 McAlpin Award.

it may be helpful if another letter is sent. If you will suggest names of
leaders outside the Department who may also send a letter, i will contact them. I
think of Leon Eisenberg as a long-standing friend, or Milton Greenblatt. Have your
secretary call me at 516—3“ 2929 so that icon do what needs to be done, before
the end of June.
My best regards.

Sincerely yours,

Max Fink, MD.
Professor of Psychiatry
.

.

»
WW»;

Ww— vu't—u'r -‘ - . -1“

�</text>
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                    <text>October 26, 1988
Alfred M. Freedman, M.D.
Department of Psychiatry

New York Medical College

Westchester Medical Center
Valhalla, New York 10595
Dear Al,
The advertisement1n the March issue of the British Journal of Psychiatry
caught my eye; hence my note to you about an article on ECT. Perhaps the editor
moved the article to a later issue.
was sorry to hear that the recommendation for the McAlpin did not
materialize; we should try again.
I

Meanwhile, I have kept up with Lothar's progress and plan to see him
tomorrow, as I am coming to New York after a month's travelling. Turan and I
presented our work at the international Pharmaco-EEG meetings in Kobe, Japan.
He did well and he has many loyal students who attended the sesssions reliably and
enthusiastically. My own impression (it was my first trip to Japan) was that I had
never seen such a fine organization nor were my questions answered so quickly and
so well in more than 35 years of attending national and international meetings. Our
hosts were most solicitous and the meetings were quite good. Martha and l
travelled about, from Kobe to Osaka/Kyoto/Nara by trains, finding them prompt,
efficient and generally clean. Language was no problem, and we thoroughly enjoyed

ourselves.

lam sorry to have missed the program in New York. My trip to the
Netherlands (seven lectures at seven universities in five days) was an educational
success, mainly because I learned much about the politics of medical care in a
socialized society. It was enough to turn one into a confirmed reactionary.
As for Australia,

I

you anyway for your help.
My

do not see myself getting there in the near future; thank

best to Marcia.
Sincerely yours,

Max Fink, MD.
Professor of Psychiatry

�</text>
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                    <text>October 18. 1967
Dr. Danie? X. Freedman

Chairman, Department of Psychiatry

University of Chicago
Chicago,

Illinois

Dear Dan.

Itii

wiii be pieased to participate in the
symposium on psychomimetics at the forthcoming ACNP meeting.
Enclosed is an abstract which summarizes the data which we
would iike to present.
0r.

and I

Thank you very much

for your invitation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszp

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                    <text>March 28, l968

Dr. Daniel x. Freedman
Chairman, Department of Psychiatry
University of Chicago
950 East 59th Street
Chicago. Illinois 60637
Dear Dan.
Sol Goldberg has written asking that I send you copies
of the enclosed reports which have recently been completed.
These have been sent to Dr. Nittenborne forinclusion in the

Proceedings of the

ACNP.

It

was a

My

best regards.

l967.

pleasure to participate in the hallucinogen
reports are published soon.

symposium and I hope the

Sincerely yours.
Max

Fink,

M.D.

Prlfessor of Psychiatry

Mszp

�</text>
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March 28, l968

Dr. Daniel X. Freedman
Chairman, Department of Psychiatry

University of Chicago
950 East 59th Street

Illinois

Chicago,

60637

Dear Dan,
Sol Boldberg has written asking that I send you copies
of the enclosed reports which have recently been completed.
These have been sent to Dr. Wittenborn forinclusion in the
Proceedings of the ACNP, l967.

It

was a

My

best regards.

pleasure to participate in the hallucinogen
reports are published soon.

symposium and I hepe the

Sincerely yours.
Max

Fink,

M.D.

Prlfessor of Psychiatry

MF:kp

�</text>
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“an.“ 1...

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March 25 , 1969

Dr. Daniel X. Freeman
Professor and Chairman
Department of Psychiatry
University of Chicago School of Medicine
Chicago,

Illinois

Dear Dan,

It is

a pleasure to enclose reprints of our reports in the
edited by Dan Efren, recalling the splendid meeting
of two winters ago. The assignment gave me great pleasure and
has been rewarding in ideas for our continued research effort.
new volume

Recently I met your associate, Jack Green in our
mutual roles as Chairmen of the Computer Committees of our
respective facilities . His novel views of narcotic antagonists
were of special interest. The differences in emphasis between
our Department under Al Freedman and the existing facility

at Mount Sinai became grossly apparent. Dr. Green seems
to be involved in the selection process for a new chairman,
and is less acquainted with the research and comnunity action

programs fostered by Al than would be desirable. In your
discussions, a description of these programs, from your
vantage point, may be nutually useful.
My

best regards .
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

ME’:kp

enc

o

e

,

.

,

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v

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tum:

October 23, 1970
Dr. Daniel X. Freedman

University of Chicago
Department of Psychiatry
950 E. 59th St.
Chicago,

Illinois

60537

Dear Den,

For many years, I have maintained an interest in ECT. When
unilateral ECT and MHECT were suggested as procedural modifications
which may improve the treatment process, we undertook a detailed
study focuased on the behavioral u neurophysiological inter"
relations. The data has been most consistent with the theories
of ECT based on Weinstein and Kahn'e studies. I am pleased to
submit this report for your consideration for publication in

the Archives.
Many

thanksfor your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt

enc .

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February 4, 1971
Dr. Daniel X. Freedman

University of Chtcago
Department of Psychiatry
950 E. 59th Street
Chicago, Illinois 60637

Dear Dan,
Some months ago I submitted our report, "Unilateral and
ECT; Effects on Memory, Depression and EEG” for your

Bilateral

consideration for the Archives.
May I
My

(Your manuscript 0658.)

ask for a status report on your review?

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>May

12, 1971

Dr. Daniel X. Freedman

Chief Editor

Department of Psychiatry,
University of Chicago
950 East 59th Street
Chicago, Illinois 60637

Box

2011

Dear Dan,

RE:

M83

0658 Revised

Thank you for your letter and critique of our ECT study
and Bilateral ECT: Effects on Depression, Memory

”Unilateral

We feund the suggestions cogent
and the Electroencephalogram“.
and we have nade the following changes and revisions.

1. In addition to the multivariate analysis, a description
of the pre« and post-ECT mean depression scores is included.
2.

The

classification of patients into endogenous or reactive
clarified, and reference to our unpublished manuscript

groups has been

deleted.
3.

a

The sources of bias of concern

to the reviewer

(non-random

assignment, non~blind assessment, concurrent drug therapy) are discussed

more

fully in the text,

4. We now clearly
each treatment .

and then noted in the Synapsis~Abstract.

state that each patient

5. The study of Strain gt_§g;,
importance.

is

now

had a grand mal

seizure

accorded a more proper

6. The sections on EEG and on memory are reduced to a few
sentences summarizing work reported elsewhere (Brit. J. Psychiat.,
Die. Harv. Syst. ) .
7.
We

and ask
My

The time

of post-treatment evaluation has been clarified.

would be honored to have
that you reconsider this

this report appear in the Archives
revision.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>Tﬂyvy,

July 22,

{Viv—V7.

«ml—m— »..

er...

“my”

1971

Dr. Daniel X. Freedman

Editor, Archives of General Psychiatry
950 East 59 Street
Chicago, 60637

Dear Dan,

submitted our report, "Unilateral
Effects on Depression, Jemory and the
Bilateral
Electroencephalogram" by Abrams, 23 £1, Is it possible to
obtain the recommendations of your editorial board ?

and

Late in April

we

ECT:

many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.

w

v1v7

»

.r...~.;;~

t rr

...

vol,

n» a. m

,

1

~

w

�</text>
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                    <text>October 21, 1971
Dr. Daniel X. Freedman

Chief Editor
Department of Psychiatry, Box 2011
University of Chicago,
950 East 59th Street
Chicago, Illinois 60637
Dear Dan,

are enclosing revised versions of our report "Unilateral
ECT: Effects on Depression, Memory and the
Electroencephalogram". we have redrafted the results section,
following the cogent suggestions of the reviewers:
We

and

Bilateral
(1)

found the

patients responding to drugs instead of ECT?
difference in clinical effects between unilateral

Are

We

and

bilateral treatments to persist after statistical "adjustment"
by regression analysis - and have described our data more fully
on page 8.

our

(2)

own

Are

differences

suggestion (P8.

due to age or not? we try to answer
on page 12-13. We were unable to

11—12)

assert that age was a contributing factor to the clinical difference
in unilateral and bilateral HOT.
(3)

Confusing pages

8—9.

restructured the presentation -

Critic is correct,

we

issues of this study are important, and
to contribute to the discourse.
The

Again,

my

and we have

believe more clearly.
we

would be pleased

thanks for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>P-

we?

March 10, 1972

De. Daniel X. Freedman

Professor and Chairman
The University of Chicago
Department of Psychiatry
950 East 59th

Chicago,

Street

Illinois

60637

Dear Dan:

It was a pleasure to discuss the opiate antagonists as a model
for the treatment and prevention of Opiate abuse, and it may be useful
to outline some issues of interest.
Neither cyclazocine nor naloxone, as now formulated, are prac—
of opiate dependence. At best, we have
been able to sustain a select group of Opiate users with cyclazocine
for up to 5 years, and some are now drug free __ but the number is small,
and I believe our success to be as much a result of the dedication of
my staff as to any specific pharmacologic activity.
But these experi~
ments demonstrate that the antagonists provide effective narcotic blockade; that they are safe; and that tissue tolerance does not develop to
the antagonistic actions. They also indicate that drug delivery ~~ a
sustained delivery of weeks or months -- is the immediate hurdle to
overcome. As the bnger duration of action of methadone and levomethadyl
make maintenance therapy feasible, so too, a prolonged
acting antagonist
would make both deconditioning and phophylaxis clinically realistic.

tical in the clinical treatment

From this point of View, there are thcee practical problems:
the development of a long-acting delivery system; identification of
more potent additional 'pure' antagonists, of greater duration of action; and, biochemical synthesis methods to assure an adequate supply
of medication.

,crn

�Dr. Daniel X. Freeman

March 10, 1972

-

1) Long-action. There are many routes that can be examined
substitution of a long~chain fatty acid to delay absorption and degradatiOn (similar to fluphenazine enanthate and naloxone pamoate); modified crystallizations (as utilized by Janssen for a long acting antipsychotic drug); investment in a biodegradeable silastic (as suggested
by the Population Council for anti—ovulatory agents); or other novel
altered delivery systems as developed by some ingenious chemists for

ophthalmic drugs.
We

have supported one study of silastic and defined the charmethod using naloxone as the base. The study was

acteristics of this

discontinued for lack of funds. It warrants continued support, despite
the long term nature and potential expense of the investment.
We

have also completed

observing that

6

initial

human

assays of naloxone pamoate,

cc intramuscular prolongs the duration of antagonism

diacetylmorphine/chlZ minutes (a 'heroin challenge') to 60
an increase in duration of at least 15 times. This salutary
demonstrates
the feasibility of the approach.
step

to 25
hours

mg
—~

A long~acting 'pure' antagonist. 0f the tested drugs, nal—
the
'cleanest' compound, hut it has many disadvantages a" its
is
duration of action is 2—4 hours; it is ineffective on oral administra—
tion (we required 3.0 grams to extend duration to 24 hours); and it is
expensive and difficult to manufacture, limiting its supply. Other
compounds warrant testing, and of these M 5050 has the most promise,
based on animal trials. To test this compound, it is necessary to first
complete adequate animal toxicology. (This step has precluded human

2)

oxone

assay for more than 2 years, for no agency which we approached was will—
ing to provide the funds. Happily, funds were approved on March 3 for

these

trials).

In addition to this compound, there are

many others that war~
have been examined by the University of
Michigan for antagonist potency, and these data are 'hidden' in the
archives of the NRC/NAB. At the request of various agencies, Dr. Vil~
lareal nas agreed (February, 1972) to undertake a review of the data;
and should other compounds be identified, these should be assayed in
man, with particular emphasis on their 'purity', degree of antagonism,
and duration.

rant study.

Many compounds

'

Under the

have returned to
compounds. This

Sterling

stimulation of Congress, various industrial concerns
their laboratories and examined their files for active
is true for Merck (levellorphan), Bristol (BC 2605),

Winthrop (ﬁ-cyclazocine), and Geigy (GPA 2163)

drugs warrant more intensive examinations.

--

and these

�March 10, 1972

Dr. Daniel X. Freedman

Finally, perhaps an interested scientistwith experience in
analgesics, could be encouraged to visit various laboratories to dis—
cuss on an individual basis, the availability of compounds or congeners
in their files. When this was recently done with Janssen in Belgium,
we were able to identify two possible compounds of interest, and to
stimulate their further study.
3) Biochemttal synthesis methods. The basic chemicals from
which these antagonists are derived are in short supply, apparently
because their manufacture is derived from thebaine, a proscribed commodity. Some effort should be made for chemists and botanists to iden—
tify other manufacturing methods and other sources of the raw materials.

In this review, I have neglected the need for training psychi-

atrists and clinical pharmacologists in the special problems of studies
in addicted persons (patients usually have a different agenda than the
scientist); the need for studies of the extinction of learned patterns;

and the need for the studies of the dependence process itself. These
general issues are of special concern to the committees of the National
Institute of Hental Health, and will surely occupy the attention of
the new proposed centers.

In our discussions of the

ways

in which these studies could

attract the attention of scientists in universities and industry, one
suggestion may be of Special interest. Should an agency, preferably

non~governmental, outline the needs for a long acting antagonist, de—
fine a reasonable deadline, and offer a prize of significance, would
this not stimulate those men who may be unable to visualize the needs
of the formulation, to attempt its development? Should an agency offer
$50,000 or $100,000 for the development of a narcotic antagonist, with
a duration of a single administration of 60 days, sufficient to block~
ade diacetylmorpnine 25 mg/2 cc/2 minutes, in man «s would this not
stimulate some interest? (An example is the announcement of the Anna
ﬁonika Foundation prize).
Two additional needs: support for academic scientists to work
directly with industry on a 3»6 month 'fellowship' basis; and support
for regular meetings of investigators interested in the narcotic antago
onists, similar to the annual methadone meetings. (When we suggested

the methadone meetings set aside time for the antagonist workers in
York and in San Francisco, our suggestion was denied. The only
special meeting was sponsored by NINE and the New York Medical College
on June 4, 1970).

Nan

�{I

Dr. Daniel X. Freedman

March 10, 1972

These are some random notes. Should you be interested in the'
will provide what I have. Meanwhile, my latest summary
as prepared for Contemponaty Dnug Pnobﬁeme is enclosed.

'back—up', I

Again,

my

thanks for lending ye your ears.

My

best regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
HF:ig
Eﬂnc;

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                    <text>7483-02683
18 January 1974

Dr. J. Silvio
Clinical Drug Studies Section

National Institute on Drug Abuao
National Institute of Montal Health
5600

Fichct'o

Lana

Rockvillo. Maryland 20852
Door Dr.

no.i

silvio:

HSM

42—73*260

wish to report that during tho quarto: October 1 to
In averaged 19 patients each month to tho
about
drug
trontnant facility at tho Notthport VAR. The majority
adminniono
tho
of
unto multip1o~drug abuoorn, including abuse of
wu

Docombor 31, 1973.

alcohol.

In the third wook of Novunbor. tho fit-t patients word in—
ductod into tho lovomothadylwnnthadonc cooperative study, and
on Dacoubcr 31, nine pationto wort inducted into the study. No
difﬁtlultico or aid. offsets have been oboctvod, and acceptance
of this ttoatnont rcginon has boon good.
During Doccubot on dotoxifiod thtco patients in anticipa~

tion thnt ooltrczono would to availohlc. Supplies not being
availablc, those pationto have boon roinductod into methadone

maintcnnnoo.
two

Staffing tannins unchanged, and on are activoly recruiting
additional counselor: for tho expanding outpaticnt part of

tho program.

Attached

is a table dcactihing the caucus for this quarter.
Sincotcly yours,
Fink, H.D.
Profcuaor of Psychiatry

Max

MF/cis

Att.
cc:

D. R.

Charlton

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                    <text>www

7m.

,7
v

x
.

.z-mwmnm

m

November 5, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives General Psychiatry
950

East

Chicago,

59

Street

Illinois

60637

Re: Ms.

#QORM

(Revised)

Dear Dan,

Enclosed are two draft copies of the revised version of
"Efficacy and Safety of Induced Seizures (EST) in Man". The draft
reflects an extensive revision and my attempt to answer the inquiries
and suggestions of the reviewers of the

earlier draft.

I trust this approach is useful to the profession.
My

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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                    <text>August 2a, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives of General Psychiatry
Chicago, Illinois
Dear Dan,
On my

return

Re:

M8

##024

from my holidays, I found your

letter of

26 with the critiques of the paper”Effioacy and Shfsty of‘lhduoed
seizures (EST) in Man? I cannot say that I am surprised, for I have
become accustomed to unusually sharp criticism of any report that I
write on EST. But I did find many of the comments useful, and taken in
the spirit of improving the product, I shall try to correct some of

July

the omissions and the errors, as well as add a section of clear critique
of the status of our present knowledge. I do think that the last request
is for an additional paper, but perhaps the addition will not be too

large

WW“?

v

.1.-r.y"-',-¢v

-_—

pwqwm'w

«serum-man“.

-~‘I:

"a,

wuwr‘

“In."-

7.,

and may be

useful.

In your letter you indicate that "I have decided my initial
reaction is off target - I enclose a letter I wrote; I also enclose Noch

Callaway's response." Neither your letter nor Noch's response were in
the package, and if you still think these would be useful in re-writing
this report, I would be grateful to see them. (I received critiques I to V).
I have some specific questions for reviewer # 2 (begins 'I
appreciate the timeliness of this review, esp. . . . '). He argues that
the issue of the comparative efficacy and safety of EST vs. antipsychotic
and antidepressant drugs is not dealt with till at all. I thought that
I have cited the principal articles in this regard; would it be possible
to ask whether there are other citations missing? If the criticism is
that the presentation is poor, then I accept that criticism and will
re-qrite it; but I do believe I have cited the most relevant articles.
I also find his statement 'there are hints of the possibly overly
sanguine clinician—enthusiast in some parts' helpful, and have attempted
to take a more judicious posture.

this

In any case, it will take a few weeks of extra-effort, but
means a delay to get the text back to you-- probably early October.
My

thanks go your

My

regards.

to write such fine critiques.
I

.m

many busy

researchers

Sincerely yours,

r-m—vm-v

’..1w:'

who

Max

Fink,

M.D.

took the

effort

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                    <text>v

”A

.._,

V

yum-awn

».--

rmnwwmwrw

ryrt’ww‘wwtwtvmj

January 3, 1977
Daniel X. Freedman, M.D.
Chief Editor
Archives General Psychiatry
950 East 59 Street
60637
Chicago, Illinois

Re: Ms “02% (Revided)

Dear Dan,

In re—reading the draft of the article, "Efficacy and
Seizures (EST)in Man", I found a number of
Induced
of
Safety
of the discuss-on and comment (pp. 30-35). I
in
the
text
errors
have corrected these, and in the event the article meets the
standards of the Archives, I ask that you use this draft for

publication.

Thank you

a healthy 1977.

for your consideration,

and my

best wishes for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>February 3. 1977
Daniel X. Freedman,
Chief Editor

M.

D.

4;;

Arehivas of General Psychiatry
Department of Psychiatry

/

Box 2011

University of Chicago
Chicago.

Illinois

60637

Dear Dan:

It is

to be forgotten in a
check
the status of
busy office! Evy I ask you to
91:02:; (Revised): “Efficacy and Safety of. Induced
Seizures

Many

so easy for u report

(EST)

in

thanks.

Min“?

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mb:

MF:fg

M
(iii;//w

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                    <text>‘7": ,.._..v_

Auzust 8. 1975

Mrs. Marilyn Freedner
28 Strathmore Road?
Great Week, New York 11023

~

‘
\K‘J

i

Dear Mrs. Freedner,

I thank you for your
gagigg orticle.
So

comments on

the Saturday

far, the experimental peptiies are in trials in

seizures (convulsive theraPY) and
in elderly patients with 'normal‘ forgetting. Should these

patients

fOIIOVing induced

continue to be successful, I have every expectation that the
experiments kill be broadened to other population samples. For
the mnenwhile, the rules of drug research prohibit trials in
individual patients with disorders outside those for which

trials

have been approved.

Sincerely yours,
Fink, M. D.
'Professor of Psychiatry
Max

;

hFer

�</text>
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                    <text>April it, 1966

m. Alfred

New

York

New

York,

H.

W

Meal college

Fifth Amua at 106th Street
New

York 10029

DearAl,

Afterywleft,m.mld0vammoanedmandcamto

mymomatll:00p.m. Wesatmddisemsedhispmmmtil
befomtm
2:00a.m.m1feltﬂmt1hadmgetmmst
smimmﬂmday. I Whimaself aasmdandoompetmt

Hamvinwdhisstudiesmllmdgavemacloarpicm
m.
ofamtinportantmaaamhpmgxm.
'me

mly diffiml‘ty in

micatim appeared to Mate to

hispmwﬂpmmmﬂhisemmlmls. Whehasspent

mtﬁmwithputimtsmdmuldlﬂmtomnﬁnminmtigaﬁms
amarienoatocbﬂﬁsmdmuldliketheopportmitymlm.
in patimt populations, he indicates that he has inmfficient

Iietaoldmhemsoffemdmogportmity tomrkwithcmrlie Shagass,
butstatodtnwouldpmfepmininginﬁewmxk. kgiwstm

mama
imam
alsoakmsamdandadeaimmdavelopapmgmaepamtefm
myprojectleacm. misbemclmmraspdceofmtmtming
towerkuithkoy,ﬁmlmfeltma"tigxt"smp.
of desiring to

in m arr-going program but

Idesmihadmymsmdypmmbutmenlhadtomclaw

that itmtndtakabetmnaixmnthsmdayearwangoptindsﬁc)

befmmoouldmasmblyhawmequipmntmthepemml
mamtoomtinuewstmias,mmdicatedﬁmthemededa

positimmwandltoldhimthatImuldmlayﬁwfollowingtoyou.

Ifmmpmgmminpmmss,mmdbeavalmbleasaocim.

especially because om could assign general qmstiona to him with
the optimim that m might
a resolution with the flair

mush Plowmamlasshemuld
ﬁmtlwhasatminhiaearliersuﬁies.

MamnimshipdthFOyIdomtthmkthatmmasmmblym
available for such studies
the
aquipmt, or pommnel
. If
Immmdyouholiewﬁwtmmmfmdsmaquipmr
labamtuy,ﬁmn1mﬂ.dsuggestyouspeaxmiouslyabmthaving
space,

himjointhestaff. mmopizﬁmistm'thiaapplimtionis
18~2Hmthstooear1yforﬁwmsmdthedxugaddictimpmm.

�Dr. Alfred M.

Madam

-2-

April a,

1966

If,

however, you would like to have him participate in the
and if independmt ﬁnding might be forthcoming
studios
mmry
for that program, than we should be able to discuss this with
him. I raised the question and his
was that he was mm
interested in alectmphysiologioal methods than in mummy function
stmias at this point.

mat

I loftthesuggestionwithhimﬂnthewastogetintouoh

withycu, orywwithhimwimintranaxt twwaeka. Iwould also
like to say ﬂat "I would like to confirm my inpression both with

RoyandHagarBridgerifyoumuldliketogoa‘madwithan
I do mt want to call Hagar unltss you are atmgly
inflmncad to nuke and! a oomdtmnt and if you an cmsidering
it, I heliavo we swim discuss Dr. Overtm'a oollahoretive abilities

appointment.
with

Roy and

Hagar.

Sincerely yours ,
Pink, MD.
Professor of Psychiatry
Max

MF:kp

P.S.

He did tell an that Dr. Rosmhamn had just 00:10le a contract
with Alan Miller for research space at Bronx State Hospital,
’a control. He traught this was
pmaunably moor «
basic science space and not patient care areas!
-e

�</text>
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                    <text>Department of Psychiatry and Behavioral Science
Health Sciences Center
State University of New York at Stony Brook
Stony Brook, New York 11794
telephone: (516) 4442990

StonyBrook

'

October 7, 1983
Dr. C. P. L. Freeman
Senior LeCturer in Psychiatry
University Department of Psychiatry
Royal Edinburgh Hospital
Morningside Park
Edinburgh EH10 5HF

Great Britain

DCarDrr-Freeman.
..

-»
_

7

-

»;
r' ."monthTedrd“revrew-“theteachingew-vMauwwactivities in ECTin this country. I have organized a workshop at the next meeting
of the American College of Neuropsychopharmacology (December 13,1983;Caribe
“

'

Hilton Hotel, San Juan, Puerto Rico). The session is focussed on similarities of
biochemical measures in ECT (and ECS) and antidepressant drugs.

At the 1983 meeting of the Society of Biological Psychiatry meeting, I gave a
special address on the history of convulsive .theraP)’, anticipating the 50th
anniversary on January 2#,'1984. The next president of the Society, Dr. SarwerFoner plans another special lecture be given at the 1984 meeting, to be held in San
Francisco in May. He has invited Professor Jan-Otto Ottosson to review the history
of theories of the mode of action of convulsive therapy.
Each year, at meetings of the American Psychiatric Association, we have
held a panel on clinical issues The sessions have been organized by different
leaders (Trevor Price of Dartmouth University and Richard Weiner of Duke
University in 1983). I do not know what is planned for May, 1984 in San Francisco. I
believe that Trevor Price and Ari Albala (University of Michigan) are planning a
teaching workshop. There is usually room for volunteered papers, either in the
regular program, or in the special sessions of the Society of Biological Psychiatry.
The section of psychiatry of the New York Academy of Medicine is
organizing a special 50th anniversary meeting on ECT on February 2, 1984. Richard
Abrams, Fred Frankel, Lothar Kalinowsky, Sidney Malitz, and Iare among the

invited speakers.

This is the schedule of meetings, as far as I know it. There is nothing
scheduled for November, 198# that should be in conflict with your program. If you
are interested in coming to the U.S., let me know when you believe your data will
be in good shape, and I will try to recommend an appropriate forum.

�Dr. C.P.L. Freeman

'
_

October 7, 1983

Page

2

talking with Dr. Crammer, in reply to my question regarding texts for
that you had written a manual for ECT, published and distributed by
Smith Kline 6: French Laboratories. He did not have a copy, nor was one available
at the Maudsley Institute of Psychiatry library. 15 it available in the US. ? If not,
how can I get a copy ?
In

ECT, he said

The furor about ECT is now muted, and more and more, I find the medical
and lay communities approaching the use of ECT with a reasonable, questioning,
attitude. There is more research interest, both by clinicians and basic scientists,
and we are optimistic that research funding will be available without the thorny
issue of ethics muddying the review process. Our principal concerns are not the
electricity/seizure issue, but the efficacy of unilateral electrode placements and
brief pulse stimuli. The Royal College report by Pippard and Ellam has been very
helpful, in suggesting that usage in the US. is not (relatively) excessive, and that
technical questions, particularly the monitoring of seizures, need special attention.

Thankfyouforjyour letter, and my best regards.
Sincerely yours,

744%
Max Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>February 13, 196‘

Dr. 3. Freeman
Racecrch Director
Medfiold State Kospital

Hadficld, Mall.

Dan: Dr. Freeman:

Dr. Violet Sunder Baa, of Fakiatan, has applied to
than: laboratories for the position of a rcuearch
psychiatrist, and has indicutcd yea it I roftrance.

I would be grataful for any information that you mny
be able to give an regarding Dr. Das' training, row
snatch abilitiuu, and intern-ts.
Theta labaratorias haw. placed an enghnaiu on

clinical

psychiatric tcsunrch, and I would be lost interaotcd
in Dr. Dns’ ability of connnniantc in a program with
our pxychitttic population.
Thank you very much

for yen: coapcration.
Sincercly yearn.
Fink,
Director
Max

NF/jb

M.D.

�</text>
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                    <text>.

.

-“n wuss—“mpg..-

“n

Irru n

(7W

‘rraw-

.ﬁw v‘Il‘ ovum—u:

“MW-r

-

:w r,..,.-u--.

r: a «‘ixﬂm“.m'*w-WVF:V*P w I‘W'wlrw wmmwmvruns-s- )Fr-l'iw.n:'.' 'n'rnv—vrvmv-r— "Wm-A-

January 14, 1971
Dr. Hugh Freeman

Hospital
Salford M68HD, England

Hope

Dear Dr. Freeman:

It was a pleasure to have you visit our laboratory. Concurrently
received the proofs of the contribution to Shagass' book, and I
The citation (#13) to
am enclosing a copy of that galley proof.
T. Rothman is listed as:

we

Changing

Patterns of Psychiatric

Crown: New York, 1970

Care

It is

obvious that we hold a favorable opinion of the role of
formulation, and concur in your interest.
My

regards.
Sincerely yours,
Max

Fink,

M.D.

Professof of Psychiatry

MF:kt

enc. Galley (Kargel)

this

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                    <text>April 9.

1965

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                    <text>April 28, 1965

Sheila S. Madman
Prunim

Mrs.

Team
Association of Marion
Imam and Amnity
Collage Ratixmnt
Rand
730

New

Third Awnm

York,

harm.

New

Equities

York 10017

Madman:

Itavoﬁlodtlnpmmmwimﬂnlhivomity

ofrﬁsmi.mdﬂuyhaveaarudtocontimoﬁwmity
payments to TIM, effective May
1955.

than, the payments for the
April. 1965. will not be

1.

months

m.

Par thia year,

of February,

Hard-1,

am

Simly yours,
Pink, Md).
Executive Director
Max

�</text>
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                    <text>September 28, 1970
Dr.

J ack

Preund

A. H. Robins
1407 Cummings Ave.

Richmond,

Virginia

Dear Jack,
Dr.

Pierre

Simon has

candidly cnswered my inquiry regarding
the enclosed articles. I have read them,
and tend to agree with Dr. Simon that the data is uninpressive.
It is particularly disturbing that the "best" results are in cases
in which other drugs were simultaneously given.

sulpiride,

and sent

me

I am disappointed with Borenstein's

had a chance to read the

than his

earlier reports.

If useful to
I

data,

now

full report. These data

that

seem

you, I will write to Dr. Nourricier.

will send the other reports, as

I receive them.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt

I have

less rigorous

�</text>
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                    <text>E

g

E

E

E

August 3, 1970
i

”“5“

"-1-“.

W

""‘ﬁ'vmfﬂdr'd’aJ'Fu-JKWu'yy‘n-w

Dr. Jack Freund, Vice President

A. H. Robins Company
1407 Cummings hrive

Richmond, Virginia 23220
Dear Jack,

I have read the reports on sulpiride (Dogmatil) with interest.
data consists of translations from French of 17 clinical studies
and one animal assay, published 1968-1969. The principal clinical
reports of Borenstein gt_§&amp;; (Ann. Med. Paychol., 1: 90~99, 1968;
and 2; 560~74, 1968) are frequently cited but are lacking in this
The

collection.

In the continental manner, case records are cited in general
terms and it is difficult to assess the data. Four groups of patients
have been treated: schizophrenia, depressive psychosis, depressive

neurosis and neurovegitative disorders.

I found the reports of Collard (1969), Mathey gt §£;.(19693 and
Naviau (1969) best for clinical material, and that of Borenstein 33 a1.
(1969) for an animal EEG study. From these data, it is probable that:

l. sulpiride,

300-1600 mg/day,

is

an

agent, with alerting and stimulating features;

active antipsychotic

2. it may have less potential for parkinsonism or seizures
than other active antipsychotic compounds;
3.

it

has antidepressant

activity, particularly in agitated,

elderly patients (Renault. 1969); and,

4. it has some anti-vertigo activity
anxiolytic features in neurovegitative states.

and may have other

citations are difficult to interpret, since the reader is
faith in the observers (it is assumed that they are known,
or that their clinic will carry the weight of authority behind the
observations), and controlled data are not presented.
These

asked to have

�-"-~“"W«W"‘

"‘N‘”V~w- "W- \"n'

s

'

u

.

~

.

‘YW‘WV1”'WWx-r4umw"‘ﬁwa-H'll'xw'va u.1~~r)'w'-UL-rwwmuw—-V". -.wo-u~.~u-‘_..,ru

“—um-v-uwr

WM!"

n;
,1
&lt;

anvvnrurv-

"yur'""b.'z

my...“

-2-

Dr. Freund

August 3, 1970

I have known P. Borenstein since 1958. He is an able electroencephalographer and clinician. He is dour, carries a heavy burden
of studies, publishes often and has well trained European assistants.
In Liege, in Harch 1959, I heard him discuss a new, all-purpose
psychoactive compound, with well defined EEG activity. I don't
recall the name of the drug, for he told me that the compound was
not available for American studies; but I believe it must have been
sulpiride. His enthusiasm did not get a good reception, since many
in the audience were preoccupied by other new compounds, chiefly
pimozide and fluspiriline, two Janssen compounds in early clinical
trial. (The conference was in Liege with Janssen support, and many
of the participants were his investigators.)

Collard’s report is also a good one. I know the director of
his choice, Professor Bobon, as well as his son. They are enthusiastic

and probably able psychoPharmacologists, and perhaps these observations
should be treated seriously.
.

If

you seek another psychoactive compound, the data of these

studies are sufficiently supportive of a broad spectrum antipsychotic
(and antidepressant?) to warrant further study. It also has interesting
anti-vertigo properties to support its antipsychotic potency.
I would suggest Borenstein's initial reports he read and his

present views be obtained.

Also, the present views of Collard and

to visit these centers, to
discuss the clinical material in detail, and to assess comparisons
with other active compounds in the same clinics. In the case of
Borenstein, it would be interesting to review his EEG material.
Bobon and Naviau.

It

may

be useful

I am attending the CINP in Prague in midsAugust. As this is a
biennial Opportunity to discuss new compounds, I have checked the
list of titles and sulpiride appears only once. J. M. Sutter, g£_&amp;l;,

of Marseille are reading:

effects of

a new drug:

”Controlled study of the psychotropic

Sulpiride.”

for the opportunity to review this material. It
that I should take better notes at huronean clinical
meetings, and will try to do so. (I am returning the translation
separately.)
Thank you

reminded

My

me

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

cc:

Dr. Tabor

�</text>
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                    <text>v

"In-1"!-

October 14, 1970
Dr. Jack Freund

A.H. Robins Co.

Richmond, Virginia

Dear Jack,

I am enclosing a copy of a letter from P. Bornnstein and
the reprints that he sent in response to my request for data on
sulpiride. In reading the papers I find littla that I have not read
before. The EEG data is, unfortunately, non-quantitative and less than

definitive.
to

My

interpretation of this data is that it adds
you posed regarding sulpiride.

clarify the questions

little

I trust this is helpful.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>January 14, 1971
‘Dr.

Jack Freund

A. H. Robins Co.

Richmond, Vtrginia
Dear Jack,

Enclosed is an answer from Paul Janssen to
about sulpiride. It is of little help.

Separately, I received

Stille

two

my

inquiry

reports about clozepine

from

is a pharmacological review and
indicates that clozapine has distinctive activity on a variety of
tests, interpreted by Stille as characteristic for antipsychotic
drugs. Angst gt 5;. is a clinical report in 126 patients with
diagnoses of acute schizophrenia and mania. The essay is presented
as a demonstration of the applicability of the collaborative,
computerized data collection and analysis system, so that much of
the text is devoted to technical features. But they are impressed
that clozapine has distinct antipsychotic activity with two important
features: no effect on muscle tone (i.e., no parkinsonism) and a
marked improvement of sleep disturbances. The separation of antipsychotic and parkinson features is considered sufficiently novei
as to become the basis of a test of the accepted theory that all
antipsychotic drugs must produce parkinsonism. Clozapine is
Dr. Hippius.

and Hippius

described as not having antidepressant or antimanic features.

If these data are verified, the compound should be active.
refer to a comparison with laevomepromazine and with thioridazine,
claiming that clozapine is at least as effective an antipsychotic as
these compounds; noting also that it has not been compared to the

They

piperazine phenothiazines.

An additional report not available to no
ArzneimitteZ-Fbrschung 19:496-498. 1969.

It sounds like an interesting compound
the reports of sulpride).
My

best.

is

Gross and Langner,

(better perhaps than

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>March 5, 1971
Dr. Jack Freund
Robins Company
1407 Cummings
Richmond, Virginia

A. H.

Dear Jack,
have been very interested in the use of narcotic antagonists
in treating opiate dependence, and since 1966 have carried out clinical
studies with cyclazocine, naloxone, methadone, and £~alpha~acetylnethadol.
Last fall I was asked to summarize our data, and in conclusion, I
attempted a justification of the logic of the need for a long-acting
formulation of an antagonist.
We

I believe that the methadone maintenance ”solution” to opiate
dependence is politically expedient but not a long~term solution. I
am concerned with the question of, "After a patient is on methadone,

what next?”

"Is he committed for life?"

The antagonist model is theoretically elegant and clinically feasible.
are committed to continuing our studies, have contracted with Food and
Drug Research for some help; and would encourage others to experiment with
other antagonists and long~acting formulations.
wi
We

Incidentally. our experience with narcotic antagonists has led us to
think of antagonists to other drugs of abuse, notably alcohol: and we have
recently carried out some studies to determine the degree and duration of
alcohol antagonism of propranolol.
I trust the enclosed reprints are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>October 1‘6, 1966
Dr. A. J. Frey
Sandoz Pharmaceuticals

Hanover,

New

Jersey

D7936

’-

DearDr. Prey:

MseofusmnIBvemtommﬂidtmingthe

pastfewyeara, feelagmatdcalofsomowathis
untimely death. On many occasions, we have discussed
I have
clinical and experjxwmzal psydnpramacology.
He
was
a
found these discussions most stinulating.
tradition.
gentleman in a very fine Enopean
My associates and I will be glad to! participate

intlneatablishnentofaednlarshipfmdinhism

,andwilldoso,ifyouwillimica’cethepmperfm.
Sincerely yours,

Pink, M.D.
Professor of Psychiatry

Max

mfkp
cc: Dr.

m1}.

�</text>
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                    <text>Ely 8.

196%

Cliuienl Nauropharuncology
Racetrdh Cantar

Williln

8:.

Aa‘Whlta building

Eltadb¢Eh Hospital

Whahlngtan 20, D. C.

Boar

Pritn:

I have just rceaivnd a lectsr of inquiry from Dr. Joseph slap,
inqunsting that I racounnnd bin for luuboruhip 1n the CERF.
while I know that charm is no formal ruquirument ﬁhﬁt nlﬂbetv
Ihip in the 01!? be ltniuad ta naubern of the national locioty,
are you an: limiting nuibershtp 1n the C!!! to those
already bsaona numbers of the next?

If not. I shall

send ya» a formal

latter

vacuumending Br. Slap.

Sincerely yours.

H” Fink,
Dictator

Dir/3b

who huvn

M. D.

�</text>
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                    <text>AuguAt 2, 1968

0L. FLLtz FLeyhan

Eston, CompLehenALve PLuehLatLy
3t. Uanent' 6 HOAthaL

neon FLLtz,

I

am

with Lego/cc! to the manuLcLLpt
Mug
ChLoLdLazepodee, aLone and combLned,

"ThLonthane and

Ln

SehLzonhLenLe PatLentL" umLeh you have eonALdeLed (on pubLLcatLon
Ln the jouLnaL. In checthq Lame copLeA Lent to me bu 0L.
HoLden, I 5Lnd that thEAQ have eonheetLon dateL thch nLeeede
the one Lent to uou 60L youL conLLdeLatLon. To avoLd any eLLoL,
I wouLd appLecLate youa estoLLaL aAALLtant cheekLng the capu
Ln noun handL.
0n the Aecond page, we have manhed the dnagt cap”
and the date. The LateL copy, Lon youa conLLdeLatLon, LL
manhed "10- 5— 67". An eaLLLea dhaﬂt, maahed "V: 5- 27- 67" AhouLd

not be

eonALdeLed.

I5 you have the connect capo, pLeaAe dLALegaLd

note. I5 you have the eaLLLeL dnaﬁt, pLeaAe
uuLL bend the Latea dnagt meedLateLu.

at a

LhLL

caLL mu oﬁgLee and we

I LegLet the LneonuenLenee, but a eonthuLng teLatLonAth
mLLeL haL Ltz handLeapA.

dLAtunce 05 1100

SLneeLeLu uouLL,

Max FLnk,
PMOKQLAOk

”.0.

04 PayehLatLq

�</text>
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                    <text>vApril
Dear

A, 1969

Fritz,

To confirm the sense of our didcnee sue yesterday, I an
taking the liberty of expending the suggestion: ».de for the 1970

progren.~

‘

of unilateral ea“ bilateral electrode place“
may seem to .e a trivial change in the
treatment procedure, but the data are .eet intereeting. The clinical
results for either placement are not similar. but behavioral change
is accoupenied by defined differen» a in memory functions and in
6N8 effects. The oheervatiene eve useful in understanding the relationships between memory function :od outcome; between Chg effect: and memory;
and in supporting theories 0 =he node of action 0f induced convulsions
described more than a deceo ago.

ment

The problem

for convulsive therapy

deny yonng contributors to the field, including
(HY), Blathly (Oregon), White (Ky), Keelhling
(HY)‘ as well as a fine group in the United Kingdom.

There ere
Snell (Indiana), Abra“.
(Ohio), Strain

A
ogrnn dedicated to the contributions of these
authors, with e' interpretation of the observations for our understanding
of the convul. ve therapy process and the treatment of affective
be consistent with the aims of the 1970 meeting. The time
disorders,
such
a review may he at least 4 hours, and perhaps, if
neceeeary :.r
some Engl ~h authors are induced to come. even longer. Such an allocation
of time ran the regular program may be unjustified, and perhaps a useful
solut . may he the holding of a concurrent tension either on the Thursday.
befov: or the Sunday after the APPA.
p

w

,

i

The financial arrangements for these speakers and the
additional expeneee of hotel end publication may be defrayed by Federal
or private granting authorities, since the subject has not yet been
covered in any national meeting. I have an HIKE contract for the

�4

'

..r.-v-.ar.m~&gt;a_w

w.

”ﬁx

4R

~2-

Freyhan

April 4,

1969

.

,

m,

.

,
_

.ww’vrnurﬂﬁn...

evaluation of unilateral and mnltﬁilo monitored ECT, and I believo
that the agency directors would be sympathetic with such a suggestion.
with the

New

With regard to the hotel arrangements, I am proceeding
York Hilton and plan to go there this week.
my

best regards.
Sincerely yours.
Max

Fink,

M.D.

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                    <text>March

4. l969

Er. Fritz A. Freyhnn
St. Vincent's Hospital
l53 Nest llth Street

new York, new York lUOll

Dear

Fritz,

It

was kind of you to participate in our resident training
program. The residents, as well as my staff. enjoyed your
discussion very much, and I hope that we will have an Opportunity

to continue this type of dialogue.

With reference to your letter about the APPA, I share
your feelings. In addition to the suggestions in your letter,
which are important procedural changes, I think we must_rsappraise the role of the members. The younger members are
discourages from submitting titlns, for they sons know that the
programs are dictaﬁndle. Our sense of participation is
frustrating and the only connection between ourselves and

the society is an identification with the leaders. Since
these change annually, there is little time for them (or
ourselves) to develop the relationship which would encourage
participation. No organization has over succeeded in maintaining

its

membership when

it has

been autocratic.

Another aSpoct is exposure. The present ways of advertising
the program soon to be inadequate to achieve the kind of attendance
that we wish. This, despite the fact that we had more than lOO
requests for programs prior to the meeting. The subject was an
important one, the sneakers were excellent and yet, as I look
back I would admit that I contributed little to a successful
public presentation.
Perhaps

it

would be useful to most

discuss these ideas.

My

host regards.

at your convonétnco to

Sincerely yours,
Fink, MOD.
Professor of Psychiatry

“3X

,ME:kp

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                  <elementText elementTextId="102966">
                    <text>..

uwn "w w

—'

wwvvz-

smwv

~

—--

1w

,mea-vv-

H'L-ﬁu‘s-Rﬁr:

-u.'1u—)Ir-» .|

vn-n“ mvmrwmzmmz-v-wwx wr-Wm K‘C,'&gt;~I!4‘_“

Dr.

um

Fritz Freyhan

New

York.

mus-news

5,

I

'W.‘"w1“"'l—'

Wam'\nv.

,

"rrww um.- a'wru—ruu-v

w evv war» '

‘Ilv‘

mea' 97"

1969

St. Vincent's Hospital
153 West 11th Street
Dear

New

York 10011

Fritz.

for the
suggestions are pencilled in
novel approaches or data.

My

The program format

APPA

and

is quite satisfactory.
reflect opinions as to

Robins probably presents a more general overview than

Ninokur.

For discussion of neurophysiology, both Perez-Reyes
relevant and novel data than Gershon.

and Bnyder have more

For an overview. Roth and possibly Dewhurst have more active
interests and relevant data than Grinker.
The meeting
My

place is shifted to the

New

York

Hilton.

best regards.
Sincerely yours.
Fink, H.D.
Professor of Psychiatry
and Secretary

Max

xi."

—_.

ran

May

‘4’“

--v

'

Mszp

.ﬂ

,

,

�</text>
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                    <text>August 20, 1969

Dr. Fritz A. Preyhsn
'

St. Vincent's Hospital
St.

153 What 11th

New

York, new York 10011

Dssr

Fritz,

IBM order shoots for the NYMC and tho
1800
computers. The differences in
St. Vincsnt Hospital
be
and
in memory may
significant for programming, and
speed
rocounondstion
that programming changes
for
our
for: the basis

Enclosed

will take

some

srs the

effort.

sincerely yours,
Pink, M.D.
Professor of Psychiatry

Mix

erkp

�</text>
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                    <text>August 6. 1969
Dr.

Fritz

Freyhan

New

York.

New

St. Vincent's Hospital
153 West 11th Street

Dear

York 10011

Fritz,

Enclosed are some notes and the reprints I borrowed
The budget may be too big. but
represents the true costs today. It can be scaled down.
of course. and I can suggest where paring might be done.

it

from Dr. O'Connen.

Thank you for the opportunity to read. what is to me,
s new and interesting aspect of psychiatry. I trust these
cements are helpful.

If you are able to pass the em on to a granting agency,
fees are SSO/hour end this required about 5
consulting
Ache
ours.
My

best to

Dr. O'Conne'ii.
Si ncere'ly yours .

Fink. M.D.
Professor of Psychiatry
Max

HF:kp

enc .

�</text>
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                    <text>October 24, 1969
Dr.

Fritz

A.

New

York,

New

Freyhan

St. Vincent's Hospital
153 West 11th Street
Dear

York 10011

Fritz,

enclosed letter was received. I subscribe to
one of the journals, Telemetry Journal. it is well done,
and perhaps, considering their unusual guarantee of
$1000/year and the history of problems with Dr. Stratton,
we should put this item on the 1970 agenda.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>«mm»

'Jrr-V‘

z—rr—rm

m"

v—-

-.rwrv:

17—.

mn.‘wm~.r

wv

_

n-

~

w-Wn—z

bnlw'm'rm-w'

mmrnfm—Eww.m ‘7va.-

October 6, 1969
Dr. Fritz A. Freyhan

St. Vincent's Hospital
153 west 11th Street

New

Bear

York,

Now

York 10011

Fritz.

Enclosed is a final draft of our rape:t “ﬁftycloserino
Tharapy of Psychosis by Symptom Provocation” for your

considcrntion for Compaehenaiva Paychtatay.

Should the other reports interest you, it will take more
editing to put them in reasonable condition for publication
(and more time).
my

best ragards.
Sincerely yaﬁrs.

Profhssor of Psychiatry
HF:kp

mu?

1m-..- -r Pp—swuvrv.

.

”.m—

�</text>
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                    <text>September 2”, 1969

...

“KW”,

my",

n

A
.

-7

Dr. F. A. Freyhan
Department of Psychiatry

St. Vincent's Hospital
153 West 11th Street
New

York,

Dear

New

York 10011

Fritz,

Attached are some notes regarding the

ACNP

symposium
would suggest

I
training in clinical psychopharmacology.
some simple
answer
to
number
centers
of
of
a
a telephone survey
psychoinstruction in clinical
questions regarding the typeandof residency
The
principal
levels.
pharm at the undergraduate
how
any,
if
texts,
often,
who
teaching,
does
the
question is

on

and format.

Copies of my notes are attached and these may form the
basis for an outline which can be used for a telephone survey.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFtkp

enc .

�CLINICAL PSYCHOPHARMACOLOGY

SURVEY

Undergraduate
New York

NYU

Columbia U
New York Med. Col.

Albert Einstein
Cornell

-

Jersey
Philadelphia
New

Durham, N.C.

Boston

Rutgers
Temple

Penn.
Duke

Howard

BOU.
New

Haven

Baltimore

Yale
Hopkins

-

Minneapolis
San Francisco

Minnesota

Houston

Baylor

Langley Porter

Stanford

Residency

/
/ (P.I.)
/
I
/

Hillside

?Analytic

/
/
/
/
/
/
/
/

Instit.

Menninger
Univ. Minn. Postgrad.

/
/
/

�A.

B.

How

is it taught?

l.

Lectures -

2.

Care Conferences?

3.

Role of Detail

Topics Covered

How many?

Who

gives?

men

—

Chemistry
Pharmacology

Animals

Physiology

Man

Neurophysiology

Pharmacy

Toxicology

Indications

—

clin. psychiat.

Management problems

1.

Selection

2.

Dosage Schedule

3.

Toxicity corrections
Combinations (synerg., antagon.)

1;

.

Rel. to clin. psychiat. - part or separate
h.

Literature

1‘.

Experimental studies

&amp;

history

J. Textbook
k.

Attendance - elective or compulsory?

�</text>
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                    <text>.

rsnwxwww

W»WWW","tau

v-vu—u-u-r,wwxm-m—wg—ww.

I’w' («warn-w.

r: m,W'a-‘was‘u-

.
..,

.-

.

.

w...”

._..

.
..

&lt;_

wwpwpw—e-

m-..

_.

September 9, l969
Dr.

Fritz

A. Freyhan

St. Vincent's Hospital
153 West

New

York,

Dear

llth Street
New

York

lOOll

Fritz,

Enclosed is our report "d-Cycloserine Therapy of Psychosis
for your consideration for Compaehenaiue
Psychiaxxy. This has not yet been edited by Dr. Itil. He plan
to go over this on Thursday and if there are any corrections these
can be made out within the next two weeks, if the report is

by Symptom Provocation“

acceptable.

also enclosing

interim report "Acute EEG Effects of
With the appropriate figures (which
are now at the artist) and some corrections in the text, this
could be prepared for publication by October l0.
I am

an

Heroin and Naloxone in Man".

After talking to you, I realized we have a third report
is being revised and may be of equal interest. This
confirmation of a paper written by Pitts and McClure in the
New Engzand Jamal: 05 Medicine may be of even more interest
to your readers.
which

_

Also enclosed are some notes from Dr. Donald Scott regarding
device for monitoring EEG in patients in coma. He is using
this in patients with cardiac arrest and it may interest you.

a

new

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mfzkp
EROS o

.u.

—

wrap-

W‘Adn-u

Inn-1"". N," V-.." nun-m—
.

�</text>
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                    <text>November 13, 1969
Dr .

Fritz Freyhan

St. Vincent's Hospital
153 West 11th

New

Dear

York,

New

Street

York 10011

Fritz,

In making the arrangements for the president's reception
are faced with certain decisions and I would like your
judgment.

we

A

cash bar will require each guest to pay $1.65/drink.

Our charge would be $35 for each
two bartenders be available.

bartender and

I am

requesting

Canapes may be purchased in one of two ways « a fixed fee
of $6.50 per person for a two hour cocktail party; or our
purchasing a quantity of food that we think is adequate at
varying costs per tray. A copy of their costs is enclosed.
The management suggests sixteen pieces per person as a reasonable
average, especially at that time of day and for a two hour period.
I

am

unsure as to the number of people who might attend

but estimate 80 to 100. If we accept the number of 1500 pieces
and use the minimum costs, I come to $700-$800.

If

take a fixed cost per person we are then dependent on
the management providing enough food. If we do it by the tray.
I believe I can request the managmenet to deliver more trays
within a short while if the demand requires. I would like
to request a variety of hors d'oeuvres initially on the basis
of 1200 pieces (12 pieces/person) with the proviso that we
order more as necessary (and funds allow).
we

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

3F:kp

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                    <text>November 7, 1969

Fritz Freyhan

Dr.

St. Vincents Hospital
153 West 11th

York,

New

Dear

New

Street

York 10011

Fritz,
Please sign the card

two account
my

office.
Many

on

the

first line

statements,as President,

and

and the
them to

return

thanks.
Sincerely yours,
Max

Fink,

Secretary

MF:kp

M.D.

�</text>
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                    <text>.. .

- two

...x..m~-...w—n;(—7....

~......—‘w,“..-W.—ww-vw,..,

.w

‘e'-‘

v"...

1,... ~....r~wu4-.r

...

.-

.

:

‘.

mmr-u

7W v.—.,_—vi,..,._.,~, ‘

V

,,..,_

1““!m'n-mevI-Iv‘r-"w-

A-

‘
v

&lt;

January 1, 1970

~w1;w.W1an-vwv

:I‘V'J-v

1.
«a

"wwwsmww.

Dr. F. A. Froyhan. M.D.
153 West 11

New
-

Dear

Street

York City

Fritz,

It

was kind of you to invite me to portioipato in the
District Branch program in March, and I vary ouch regret that
I will be in Denver during the neck of the noeting. I have discussed
the problem with A1 and he concurs in the recommendation of our
associate, Dr. Arthur Zakn to complement his presentation.

APA

Dr. Arthur Zak: is an Instructor in Psychiatry in the
Department. Since 1966, when he was a resident. he has been intimately
cosociatod with our studies of oyclazocinc, heroin, noloxonc and mathadono. He is fully acquainted with our data, add has attended the
rcccnt meetings of the HAS-NRC committee, no that he is fully
acquainted with the work of other investigators. (Incidentally, he
is also a yrincipcl in our studies of cannabis).

I underntcnd the proaontation in on March 12 at the
Academy of Hodicine. I will anoint him in the preparation of his
roport, and am confident that he will do a commendable job, in
doocrihing tho ptoocnt approaches to the treatmcnt of Opiate de~
pendonce and a vino of tho future. with particular emphasis on the
development of a long acting naioxonc.

‘A'W‘I'

.'
.m

.vww

.-

rwm-w,s.-;m:ywm

van-YT

mmxvm

.
1571909.

'7.)

an
.7:

“FHP'

veer.

”.31;

4'1

Im-

Incidentally, for the January prosontation (Halon), A1
recommends Dr. Myron Denholtz as a discussant. Dr. Denholtz has
been a student of Wolpo's and 13 an activn participant in our programs.
Sincerely yours,
ﬂax Pink, M.D.

�</text>
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                    <text>rum

‘T‘iw-vﬂ“

n,‘

«w

-

-

wine-1m

:‘.‘$-uu)'

y 'u; “4.x";

wmmmwsw.weuwy:+_a~‘ruw.’v¢-K'Wru-‘v&lt;'wV"”rr:u‘|.n-'T~WIW rv'vww‘

«Mm

m

I("'arlyF‘-,vv -

1

.77;

.

'."~'-".‘——

r

.,

rm,

November 19, 1970

Dr.

Fritz

A. Freyhan

St. Vincent's Hospital
Street

153 west 11th

New

York,

New

York 10011

Fritz,

Dear

correction for the ﬁinutes will
trust the record reflects our discussion.
Your

For your information, I have asked

the information regarding the Editorial

entered,

secretary to make
journal.

It is clear that

Sincerely yours,

7"“.w—u—vﬂ.

rm.p:"

Max

3.”

mm,

..,

MF:kt

w
‘-

P"»"WF'uI/D—v~

c
»

-‘uTmM'

Fink, M.D.

Secretary

&lt;

me

I

Board of the

,-

~1ﬂm'wmwmguv‘mr

and

the journal is a creature of Dr. Stratton,
that the designation of "official journal" is nominal. In
view of the other changes at Grune &amp; Stratton, it would be useful
Councillor) could review
if you (as Editor-in~Chief and an APPA APPA
and suggest to the
the relationship of the journal to the
which
would
perhaps establish
publications committee a course
the journal truly as the "official journal"?
and

Vnr'M‘I—v'

my

be

.—.~

7-.

~34."

�</text>
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                    <text>February 26, 1971
Dr. Fritz A. Freyhan
St. Vincent's Hospital
153 West 11th Street

New

Dear

York, New York 10011

Fritz,
Thank you

for the Opportunity to read the report

"An EEG

Loss During Alcoholic Intoxication" by Freeman,
Goodwin and Othmer. For the reasons described in the attached

Study of

Memory

critique, I find the report unacceptable for publication in its
present form. The subject is an important one, but the contribution
is too inconclusive to merit the space. I believe the authors have
better data ~ I hope they do, in any case ~ and that could be the
basis for an acceptable report.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
0116 o

�</text>
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                    <text>wwww‘rr-wx‘

1‘

w,- um.

.z-w-

vvvwm.mw: ‘m‘

.

'

&gt;—

,

Wmv'm~om'-rummwr 7.72:»

--vv

February 9, 1971
Dr. Fritz A. Freyhan
153 West 11th Street
New York, New York 10011
Dear

Fritz,
I

am

most

gratified

in the Council of the
for your confidence.

me

by the support chat you have given

APPA.

I wish to express

my

thanks

I would be honored to join the editorial board of
Compnehanaiue Paychiaxay and shall do my best to support
the traditions of the journal.
My

best regards.
Sincerely yours,
Fink,
Secretary

Max

MF:kt

M.D.

�</text>
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                    <text>February 1, 1971
Dr.

Fritz Freyhan

New

York,

St. Vincent's Hospital
153 West 11th Street

York 10011

Fritz,

Dear

as I

New

I

was honored by the Association's election as Secretary,
by the renomination. It was specially kind of you to

am

describe my service as secretary as particularly useful to the
Association, for I have tried to exercise the responsibilities
of the position to the continued growth of the organization.

If the services have been of such merit, perhaps three years
is sufficiently long to judge whether stewardship should be
extended. It is unclear to me why the Association insists on
longevity in

some

positions

and not in

others. Nevertheless, I

have found the position of Secretary regarding and interesting,
but no longer challenging. While I would be honored to continue
to serve the Association, I would not appreciate another term as

secretary.
Among

the complaints of the

was the lack of opportunity

members

regarding the association

for participation.

belief that the Association should involve

It

more of

has been

its

my

members

in the program and the Program Committee; in the council; and in
the publications. So far I have been successful only in encouraging
additional participation in the committees of the Council. Perhaps,
encouraging a transfer in the office of secretary after a few years
will provide a model for other positions in the Association.
Again,

my

thanks for your kind words and recommendations.

Sincerely yours,
Fink,
Secretary

Max

HF:kt

M.D.

�</text>
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                    <text>_,

June 9, 1971
Dr.

Fritz

New

York, New York

A. Freyhsn

St. Vincent's Hospital

Dear

Fritz,

I an pleased to submit our report, ”Cyclasocine Treatment of
Opiate Dependence ~ A Progress Report”, for your consideration for
comprehensive Psychiatry. The opiate antagonists have been studied
since 1965, and despite such clear evidence that they are safe and
useful, see not used, often because some early students recall only
the side effects, observed by then when they were learning and when
their doses were excessive.
I have proposed to the President
a prophylactic agent in our troops in
for more efforts at developing a long
with adolescent papulstions should be

It

would be

helpful to

relates in the literature.
Thank you

have

that cyclasocine be tried as
Southeast Asia. There is need
acting formulation. Trials
undertaken.

this report

and the experience

for your consideration.
Sincerely yours,
Max

Fink. M.D.

Professor of Psychiatry

Mr:kt

it

-—

W'W

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                    <text>September 13, 1971

Fritz Freyhan,
Editor,

M.D.

Comprehensive Peychiatry
153 West 11 Street
New York 10011
Dear

Fritz,
I

am

pleased to enclose a draft copy of a report of

our experiences with multiple monitored convulsive therapy,
Clinical Experiences with multiple Electrooonvulsive Treatments,
for your consideration for Comprehensive Psychiatry.
We have been able to assess the clinical efficacy
and the effects on memory of unilateral electrode placements,
and these studies led us to multiple treatments. We have been

surprised that the clinical results of multiple treatments
is not much greater than one seizure—- suggesting that the
biochemical changes after one seizure are near maximal, and
that some development, in time, is necessary for the full
development of the changes which are the basis for clinical
results. The finding is similar to the observations with
antidepressant medications.
I believe the report will interest our readers.
my

best regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

�</text>
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                    <text>'vmm'

Novenber 18, 1971

Dr.

Fritz Frcyhcn

St. Vincent's Hospital
153 West 11th

New

York.

Dear

New

Strﬂet

York 10011

Fritz;

Encloeed is a revised draft of our report ”Clinical
Experiences With Multiple Electroconvulsive Treatments".
We have reduced the
tett as suggested.
Again, our thanks for your consideration.

Sincerely yours,
Max

Fink,

24.1).

Professor of Psychiatry

MF:1g

Enc.

�</text>
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                    <text>19 March 1974

Robert Spitaar, M.D.

State Psychiatric Instituto

ﬂow

York

New

York.

722

“but 168th Street
New

York 10032

Dcar Bob:

Enclosad is a copy of the raport, "Brain Function, Verbal
Bchnvior. and Psychothcrapy." for consideration for the APPA
volumn.

I shall try to provido a prettcu within the next
cats 30: Zubin's suggastion.

and V11;

few days

I want to take the opportunity to thank you for satting
such a fine matting. If ch. rest of the Association anjoyad
as much II I did. then it was not: successful.
My

beat regards.
Sinccraly yours,
Fink, MODQ
Profcacor cf Psychiatry

M33

MF/ci:

Encl.

up

it

�</text>
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                    <text>August 23. 1963

mats-51.8 mm,lA.CuN.P.
mu.
Clinical Memphammlogy
Wm
CI,

Baum-ch Canter
Building

William A.

MIME,

Saint Elizabeths Hospital

Hashim.
Dear

for

Do

Mu:

It is

with

CO

pleasure that I mud Dr. Sam Ger-sham
mat
in the Marion 0011933 of Neuropsydwpharmoology.

Warship
is a qmlified psychiatrist having mmivad his

a». When
Afmr this

mm.
mud

W. mntly
career

was

D.P.14.

In has marked in pharmacology and during his
the Pfizer Scholarship for Medical Research
~

Rom

Scientist
bun appointed Principal
During
Nissan}.
Paydmiatry.
of
Institute
the
(Framing?) at
shown
himself
he
has
tomonths
his'tomzm
of
to
five
date,
the
investigator.
brilliant
bo an
and
‘

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has

mtic
I heartily WM

‘

him

for

Whip.
31110321137

W

m Fink.

I

yours,
M.

D.

�</text>
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                    <text>August 25. 1963

mm Wm, A.C.N.P.
Clinical Neumpimmcolcy Research Center

I». Fritz

A.

CI.

William A.

minim,

HID-ﬂ,

\

Crodnntiels

mite Building

sum; Elisabetta Hospital

mm.
Fritz:

Do Co

Dew

Whip

in the
It is a. pleasure to monument Er. 'l’uran Itil for
Mariana College of Hempsychopharmcology. Dr. Itil is e mater of
the Collegian Internationale Memo-MWogim and Arbiteminwhnft for Nemmydxoprmkclcgie. For the past ten years he
has been working with meesocr Flugcl in Erlmgen. Rio contributions
concerning psychopharmcolow and the EEG changes in peychmtric
patients are well known to you.
In March, I». Itil joined my staff on leave from the University
of Erlangen. He has been appointed Principal Research Scientist
(EEG) to the msacxmi Institute of Psychiatry.

Imuldbopluecdifhemacccmcdfclmhipinmmﬂm
sincerely 3mm,
m3 Fink,

Erector

Me Do

�</text>
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="81320">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="87881">
                <text/>
              </elementText>
            </elementTextContainer>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="94442">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
