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                    <text>Jun. 18.

1964

ﬁr. Jonathan 0. Cal.
Editor. PIyahophnrlncolosia

Paychophnruncoloty Surviea Cantor
National Instituto o! Hc¢lth
Bethcudn, uhtyland
Dcar Junnthau:

I an plcnuod to ﬁaclosc tun copies of tha final draft of car
ahlarpronnztnc~laﬁpruninn-planabo :eudy ta dcprosaton for your
countatratian for publication in Psychophnxlncolasia.

I tried to convincc Lao that an abould publish both import: on
dtprcsalon coauthor. but ha appoaxad anxioua to: a not: popular
yr!!! and indicntcd that ha would aand hi: :uport to tha JAHA.
Dr. Robin: call-d an runsday about another nutter. and tndicatad
that he had apahnn to you about an outwpnttcnt deprutotaa ttudy.
In tbs avunt that you plan :9 can. to St. Louis on a site
Hhxtha :nd 1 would ha plgaaod to‘huvu you only with an, andvisit.
I
hop. 1 will hnvu an appartunicy to htvu yuu visit :ha ragtituco
and chnt'wtch Inns of my couworknrs.
my

b0ut lusnrdt.
ﬁtacctnly yaurs.

rink. H. D‘
m
Director
33/1»

nae.

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                    <text>July 13,

1960

Jonathan 0. Cole. H.D.
’Peychophatmacolosy Service Center

National Institutes of Health
National Bank Building
Bethesda. Maryland 20014
Dear Jonathan:

I have sent off
a pleasure to talk to you on-Friday, andwishes
the application to you. If I understood your which correctly.
You would
about
you ﬂmplied that there are other things would
be pleased to do so
I
like we to visit you in Washington. weeks
are busy onea for me
on my way to New York. The next two
will
as I meat secure all the programs of the Institute. since I
be away for six weeks.

It was

via
I can arrange to go TWA
take
Washington and, if it is convenient for you, I will
flight 86 to Friendship (arriving at 1:37 p.m.) and be at your

I plan to be in

New

office between 2:30

My

York on July 29.
and 3:00 pom;

best regards.
Sincerely yours,
Fink.
Director

Max

MF/jb

M.D.

�</text>
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                    <text>Saptembe: 11, 1964

Jonathan 0. Cole, H.D.

Psychopharmacology Bartlet Center
National Institutes of Health
Bethesda, Haryllnd 20014

Dear Jonathan:
aha memorandum regarding the October 15th
of
the Committee, and the latter at June 15th from
meeting

I have just read

Jim Ewing.

Jim’s letter is difficult to interpret, and I am not refl
taunted about the available arrangomnnts for this unit's
participation. According to the letter, no person is working in the program full time and while.there are an adequata
numbar of people to participate in tho program. I ha»! the
distinct fucling thnt the patient: will fall between the
aim. shifts of the many investigators.

I believ; that it
the Guumittca to

for another mamber éf
the
unit
at
this
present tins.

wou1d_ba important

visit

Sincerely yours,
'

Mu Fink, u.

Director

m,»

1).

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                    <text>September '18, 1964'

Jonathan 0. Cole,

M.D.

?aychopharmacology Sarvica Centar

Rational Institutes of Health

Bethesda. Haryland 20014
Baa: Jonathan:

is tha revised voraion of tho report "Clinical Effiw
of
ChlorpromazinAnProcyclidine Combination. Imipramine
caoy
and Placebo in Dopresaivn Disorders". I beliova that we have
anawarud each of the criticisms of the readers, and trust that
the prasant revision masts with your approval.

Enclosad

'

My

base ragards.
Sincerely yours,
Fink,
‘th
Director

Mfljb
Em: C

M.D.

�</text>
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                    <text>new 31, 196“
Dr. Jmattmn 0. Col:
and Coordinating

ngm
W,
mm

Aoch.

'

.

8m]: Building
Bethesda, Haylmd

Dear

Wm

Jmﬂm:
Jim Team and

I havudiswssed the forthcoming section

mﬁnginJmmy. Ikwinmmtoindicamﬁutwe
would like to

hm 'pmjectim equipmnt available and will
spend our study amp time to discuss the paper presented
by Quarks Shapes. Widening the format of the mating.
I mommnded that

invite-Dr. Tum 11:11 to present a
stat-mt of the diffemtial effects of drugs a: the
in patients with depressive and nondepressive psymatic states. Jia med, and Ttman will be
pmpamd to make this- kind of maentatim.
.

we

WWI-W
summary

Astorthemsterofﬂmstudym,
ﬁwbestlham
of participmts at the various study
ﬁst
sessims. For

available are the

group

of fellows of the

yew Mormtim, I an

mm a list

mm parddpated in our session.
I look forwaNtosoeing you in the middle of January.
0011933 whc

Sinoemly yours,
Mm:

Fink,

Dimcm

mfsls

I‘M).
'

�</text>
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                    <text>Inbruaty 26,

1965

Dr. Jonathan 0. Cola
lational Bank Building
5917 Arlington Road
Bathaada, Maryland

‘Daar

Jonathan:

Attaohad ara work shoots which raptaaant various budgats for
tho supplanantary taguaat HH—llS80~Ol-Sl. Tho budget is in two
parts. rapraaanting the oontinnation of the oomputar studios of
EEG for tho ranaindor of tho grant patiod (18 months), and
out
participation in tho Collaboratiwa Schiaophtania Study;
Tho portion rapraaanting the computar analysis will permit us
to pay an; Don Shapiro at a now salary rats which will batons
afiaotiva upon hia baing awardad the b.8o dagtaa from Washington
Bnivatilty. Tho salary diffatantial in that which tha University
would pay him as a manta: of thoit faculty.

Ina supplanant also will pay for a continuation of our contract
with washington Univaraity for oonsultationxaod IBM 7072 computer
tint. Also. we awn asking for additional funds to rant a high
apaad printer whith will patuit us to ba on~lina for our analyaas
dating the final yaar of this grant. Thane thraa portions. salary
diitarantial for Mr. Shapiro. consultation with washington Univarsity.
and rental of a high opaod printer, will make possibla the analyses
which wata projaotad in tho original grant applioation.
tho portion natkad "B” raprasants tho Collaborativa Study. I
hawa taviawad my work load for tho naxt six to eight months and

it

find
vary haawy. If you wish to have this supplaonntary dtudy
dona. wa will do awatything possibla to accomplish it.‘ ﬁowwwar, in
viaw of my toanittnanta, I would dean
a grant adwantaga to my
programs if we did not undartaka this study this yaar.

it

I trust that tbs ranaindar of thin budgat is olaar.
Baapactfully aubaittad,
Ha: Pink. 8.0.
H331:

Profasoor of Psychiatry

�</text>
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                    <text>March 8, 1965

Dr. Jonathan 0. Cola
Hatianal Bank Building
6917 Arlington Road
Bethesda. Karyland

Dear Jonathan:

I am‘wtiting with ragaré to tha grant application entitled
”Early Clinical Psychotropic Drug Evaluation Program" aubuittad
on Iabruaty 17. 1965. Following our diacusaion of Hatch 1. reviawing this grant application and our propoaad collaborativa
study prograagwith tha University of Istanbul. I would lika‘to
rvquaat the withdrawal of this grant application. An soon as it
in availabla, I will submit a new grant proposal entitled "A
Collaborativa Clinical Drug Evaluation Program? which will incot~
potata many of tho program poaaibilitiaa anvisioned in tha praaant
application. but also include the specific modifications which an
haw: diacuascd regarding the collaborative aspects in Turkay.
Thank you very much

progra-

for your help in dcvuloping this study
Sincaraly yours,
Ha: Fink, um.

Hrzja
cc:

Dr. George Ulatt
Dean William Bryant
ﬁt. any Baaoui. Comptroller
Tutan 1:11. 3;».

'

Profcaaor of Paychiatty

~
_.\
y.

.

�</text>
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m. Jcmathm 0. Cola

Natimal Institute of

25, 1965

Manta]. Health

Maximal Bark Building
6917 Arlington Road

Bethesda, Marylmd

Dear Jonathan:

I have received an invitation farm the 0mm State
Boaz'dofmnmltoparticipaminawomshopmpsy‘
therapy. Dr. Berger intimated that you had mmde
m,andlwnindaedgmtefu1formiaoppomtym
visit Oregon, a state which I have mm visited before.
mam you for thitﬂdng of ma.

Sixmly yam ,
ﬁnk, PM).
meeasor of Psychiatry

Max

Mszm

�</text>
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                    <text>May

25, 1965

Dr. Jonathm 0. Cole

Hatimal Institute of chtal malth
Ratiorul Emir. Building

m
Bethesda, 24un

6917 Arlington

Dear

1

Jmtrun:
Exclcudmacopyofﬁmpmmcclmichm. Itil

dempchcimintMmlysiaofEEC—EW»

part of the Collabomtiw Schiacpmvnia Project. If
Mmmyocmctimswhidzyoubclimmmm
made, phase do not mitato to write an.

wcmplarmingmhmcmofm'. W'etcchniciam

visit with us far a 2—week period, and than have our
electronics todmicimgctoﬂew‘forktoinatallthcaquip-

mtassocnmthomcrmtnhaveboendeuwmdto

~

Mutter: Stat: Hospital.

85.anle yum ,
Max

Mmjm

PM.

14.1).

Professor of Psychiatry

�</text>
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                    <text>Hly 26, 1965

0.
mm
National
Institute of mm Health
€010

Dr'o

‘

Natimnl

Bank
6917 Arlington Read
Beﬁxesda, kryland

Dear Jonathan:

missed is acopy of our

gmabnrbiml effects in

me

analysis

of

volmtms. This pmject was mdermkaen to develop the wands to dimrinﬁnata
effects.
rm critique :31 pan; 18 imﬂcam rm problem.
we faced.
'

.

‘

Immliglmedmtnnsmﬂntmcmrmammﬂml
andweam
motﬂapmisnmmuﬁngmywen,
planning to mdemm other diwriminatims of pswmnupic
stimulants in volmtews m prwide
:3li
Wine.
am
Ihopetlutthismpwtintemstsyou.

commas and

far cur studies in

Sincerely yours,
Mac Pink, 1-1.1).
HP:

_

511:

E nclomm

Fromm of

Psychiatry

�</text>
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                    <text>July 1a,

1965

Dr. Jormthan 0. Cole

National Bank Building
6917 Arlington Road
Bethesda, Marylmd
Dear Jonathan:

Haw received the GIMP Bulletin No. 1. I am delighted
with the program outlined. I mean your telephone call of a
few weeks ago and would be pleased to help plan one of the
sessions but do not know if I am autlnrized to proceed and, if

so,

how. Please
My

advise.

-

best regards.
Sincere 1y yours ,
Fink, NJ).
Professor of Psychiatry

Max

M'mp

P.S.

for your oo—opemtim in the ECDEU application .
meet I wwld hope to have an opportunity to clarify

(Thank you

Whon next we
my pmsent program .)

�</text>
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                    <text>August 21, 1965

Dr. Jonathan 0. Cole

Natimal Bank Building
6917 Arlingtm Road
Bethesda, Maryland

Dear Jmathan:
thank you for the time you were able to
me last week and for your kind expressions of
condolences. I think that my family has begun to adjust to

Pimt let

spend with

me

most interesting feature was the my expmssims
of gratitude by my fatimr's patients, my of whom had been
with him mm than two decadas. A mzmber asked whom also
could they find a general pmctitimer today, and their

our loss.

A

question was a
medicine.

comm

on the

dmmtic chmges in

American

I are pleased to send you copies of
an initial report on the schizophrenia program, for your
consideration for the America: Journal of Psychiatry or
My

(so—workers and

Psymophamacologia. If this draft is aooeptﬁale , we will
Sand original glossy copies of the figures and adjust the
mfemnoes to meet the style of the appropriate joumal.
Thank you

for your consideration.
Sincerely yours ,
Max

Fink,

M.D.

Professor of Paychiatry

Mszp
enclosums

�</text>
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                    <text>December 21, 1965

Dr. Jonathan 0. Cole
National 3m}: Building

Arlingtm Road
Bethesda, Huylmd 20913

6917

Dear Jonathan,

I

writing to request permissim to expend e portion of
(Watchmen
for international travel to permit my participation: in the sympoeixm
”Electrophysiclogicel emulates of Behavior“ at the XVIIIth Inter~

,_

am

mmam—um

mimlccnmscfhymclminﬂcecmmﬂngmeﬁmtweekin
Mist 1966.
In the renewal must fcr Iii-11350432,- a sun of moms
requested and approved for intemtimal travel to permit
While I believe attendance at
ettendmce at the German

thiemtingwwldbemcsthelpful, I wwritingtcrequeet

tc participate in the International Gangrene of Psychology
on qumtitative aspects
Weiforamnesia
such malycee which have hem
of 336.1!“ scientific methods
approval

since they have planned a
produced by

scientists behind the ircn curtain have sham

much

SaucfthematezielueepmtedinﬁmemdSalzbuI-g
praise
and believe
research
will be enhamed
that our
materially
I
pmgrm
the cpportmity to participate in this symposimz and to visit
and mivmcv.
of the.
the

by

mm

mama

Hey we have your appmval for the allocaticn of this sum to
permit participetim at this meeting? (Incidentally, the emcee
will pmbebly be $369 higher. If it is possible to allocate this

ward. ﬁxinmldexpedite
mtfrmmctherpertcfﬂnmt
the visits described.)
Sincerely yours ,
Hex

Pink,

14.0.

meeascr of Paydaietry

Principal Investigator
Wzkp

cc:

Mr.

m.

11:11
7

�</text>
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                    <text>Jm--v.x=-ym;_.w.y.wc-:T

Wh—

'7‘:

upm-

~»-

Search

1, 1966

Jaaﬂun

O. Gale
National Bank Building
6917 Arlington Road
Bethesda. Maryland 2001»

Dr.

Jmﬂm,
Itgivesmmatpleasmtosendymadmftcopyof
m:- mnual of digital computer methods for EEG analysis. This
represents our first major moraine]. report of our experiences.
Dear

Weheveelectedtoincludempmmmdtopxwideﬁae

knowledgeable reader with

amventionel diam

sufficient data so ﬂat with

13mm shout! be
ebletobemdifiedmdmeesily. Imtekingmeliberty
commuters

the various

ofemdingoopiestomofﬂnmmmoftheeliniml
mitten who are interested in the develowmt of this
prom. MImﬁomdtoyou.wemnotmn-eabwtthe
beat way of presenting this publicly. I would be gmteful

fovymmmmmndetiammtowheﬁmrthisdommthassm
its availability 9mm:- laboratory.

value beyond

mm): you for yaw

momndetims .
Sincerely yours,
Fink, NJ).
m
Professor of Psychiatry

�</text>
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                    <text>April 11.

Dr.

0.
Jmﬁm
Bank

Natiaml
8967

1966

Cole

Building

Arlimtm

Road

Bahama, Maryland 2001a
Dear Jonathan.

RE:

”141380-02

Mammpriam ofﬁcialsofﬁnlhimityofﬁissmm,
Eula have approved my mqmat to participam
mum»
of Payclmlomr, Augusta—11, in
inﬁnlnumimal commas
Moon.
of January 7. maybesufficiant, I
includﬂxg

Wth

maummﬂymmdmummﬂdamwpyofm
umlauﬁmizatimorhxdicauinmoﬁmwhtewaythe
appmvalfortlnexpmditm ofﬁnsefmdsfmm—IIBBO.
My thanks.
Sincerely yours,
Max

Pink,

14.)).

Professor of Psychiatry

�</text>
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                    <text>April 20,

Dr.

Jauthm 0.

Natimal Bank
5917 Arlingtm

1966

Chin
Road

Bethesda, Maryland

Jmaﬂm,

Daar

IE:

Iii-41380

I am writing you as project officnr for Iii-11380 to bring
youm—to—daucnﬁnpmmtstatoofﬂnpmjact. AsI
indicatodinOctober,IwillbolaavingSt.louisaarlyin

Atﬁuttim,ﬂudataoollactimmdmofﬂndata
arulymwillbomlam.

Jmo.

mmwillbefmdslaﬂinm~11380andmmccming

Maulyuacmmnﬁnmmdarmaupmisimcfm.Itil.
Fwﬂﬁsmmlmmstadmmmiwmitymdm
writing to you to momma! that Dr. Itil. the eta—investigator
of this pmject, be appointed principal investigator for the
Wimdﬁupmjectpcriod.
,

mm,m1imimtadﬁzatmenmybam

marminingmﬂmtmwmadbchalpfuItomhm
the malyses $.an York,
mam-y woman-es
forﬁnhandlingofymtfmdammlocaﬂmcfﬂnprincipal
be fbnoud. You may mean that the mimity
suggestadmdtemte
thatofasubcontmct. ’mis

iner

1:»quth

mm,

canned agmaabla. although novel.

Apparently.

ﬂuwitingofwd'xaomtmctmnovelm

the antiwrities at the adversity of Nissan-i and to this date,
mamhmntracthaebmwritm. Mpmjmdbalmmforﬁn
want at the
period, September 30, is estimated
$8,000 and $12,000. The Assistant Chaim of the

mam
ham
Deparwmhaaasamdmﬂutmofﬁmseﬁmdsmyyet

bawailable dtn'ingﬁnamrmnmspmvidede couplem

tha necessary legal steps.
'v

hwmmmmmMymsatmemmmmm

of Payohiauy installatim, I balim that much of the statistical
work can be acmlished at Hashingtm thivamity. Drywall Stmpim,

�April 20,

Dr.

Jauthm 0.

Natimal Bank
5917 Arlingtm

1966

Chin
Road

Bethesda, Maryland

Jmaﬂm,

Daar

IE:

Iii-41380

I am writing you as project officnr for Iii-11380 to bring
youm—to—daucnﬁnpmmtstatoofﬂnpmjact. AsI
indicatodinOctober,IwillbolaavingSt.louisaarlyin

Atﬁuttim,ﬂudataoollactimmdmofﬂndata
arulymwillbomlam.

Jmo.

mmwillbefmdslaﬂinm~11380andmmccming

Maulyuacmmnﬁnmmdarmaupmisimcfm.Itil.
Fwﬂﬁsmmlmmstadmmmiwmitymdm
writing to you to momma! that Dr. Itil. the eta—investigator
of this pmject, be appointed principal investigator for the
Wimdﬁupmjectpcriod.
,

mm,m1imimtadﬁzatmenmybam

marminingmﬂmtmwmadbchalpfuItomhm
the malyses $.an York,
mam-y woman-es
forﬁnhandlingofymtfmdammlocaﬂmcfﬂnprincipal
be fbnoud. You may mean that the mimity
suggestadmdtemte
thatofasubcontmct. ’mis

iner

1:»quth

mm,

canned agmaabla. although novel.

Apparently.

ﬂuwitingofwd'xaomtmctmnovelm

the antiwrities at the adversity of Nissan-i and to this date,
mamhmntracthaebmwritm. Mpmjmdbalmmforﬁn
want at the
period, September 30, is estimated
$8,000 and $12,000. The Assistant Chaim of the

mam
ham
Deparwmhaaasamdmﬂutmofﬁmseﬁmdsmyyet

bawailable dtn'ingﬁnamrmnmspmvidede couplem

tha necessary legal steps.
'v

hwmmmmmMymsatmemmmmm

of Payohiauy installatim, I balim that much of the statistical
work can be acmlished at Hashingtm thivamity. Drywall Stmpim,

�</text>
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                    <text>April 25,

1966

Dr. Jana-sen O. Cola
Natimml Bank Building
6917 Arlington Road
Bethesda.

Muslim

Jmﬂm,

$11381
I awaiting to you as
officer for BEL-11381 to
bringyouwm-dam an ﬁnpmmt state ofthis project.
Dear

RE:

13ij

w.'nm1tilmsbeenaprincipa1inmtigatormlhave

bamdeliwmbausmmadwithhmmﬁmdevelopmnt
ofthisstudypmm.
Appmximhaly fort-y patimts have been introduced into

tin‘initialpmmmmaddiﬁmalmymmbeing

The mkyaioloﬂcal, psychophamlogical
massed.
and clinical aspects of the first forty patimts are now
minted. MWmdfollowwdammnmbeing
obtaixnd. 1113

Wichgieal

M

of subjects am under intansive
md pharmacological study.

second

Effectim Jam 30, I can no lmgar continua fomally as
wizmstigator. Dr. Itil md I have considered the possibility
that mntinuationofwintomst inthis studypmgzmnaybe

pmvidcd m advhoe. consultant basis and

I have indicated that

ImldbeplemdtoassisthiminmymythatIcm.

Myltahethisoppomitymthmkyouforwursuppwt

Mmmgamntinﬂradevelomtmdmntinmdgzmthof
thiasmdypmm.
Sincerely

yam ,

Fink, 14.1).
Professor of Psychiatry

Max

ac: Dr. Ulett
Dr.

Itil

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                    <text>Dr. Jonathan 0. Cole

Netioml

Bank

Building

6917 Arlington Road

Bethesda, Maryland
Deer Jonathan

faded with e amber of technical and administrative
with
regard to the preparation of a grant application
questions
New
York
Hedieel Galley for the Ice—establishment and
free the

I

am

malytio program for "BBQ and Human PsychoRetherﬂmepmdﬁmtimonﬂretelepmor
in letter. I believe we both will be in Atlantic City for the
meetingamxtwasm Implaminatemive Tueedeyeftenmn
and Thursday. Except for my
and will be available
2:08
preheateﬁm on “muredey at
pm... I can set aside any tine
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Wiley."

may

on the rant of the schedule.

that

I

we

assist

would be

Wain). if you would indicate a

My

m

in the privacy of yew
to
in the preparation of this project application.

might get together

me

half—hour

twat
Sincerely yom‘e,

m Fink,
Professor of Psychiatry
24.13.

ﬁxjmh

�</text>
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                    <text>May

16, 1966

Dr. Jamthm 0. Cole

Maximal Dam building
8917 Arlington Road
Bethesda,
Dear

mm

Jmﬁma
I

enjoyed our mating in Atlantic City.
m suchmats,
I thwght it
be helpful

Following yum

would

is ask We to Wider his positicm

the transfer of the equipment which was broughtnew
from
1 hope that I can nominee him that
Hillside
this is a
wiﬁmut having so ask

to

with

Mini.

any

m

minis We
official Wiestion.

andadvioeinﬂw
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Whydmhmoology-Omtar study

proposed

My

WOW.

best regards.
Sincerely

mm, m).
meessar of Psychiatry

Hex

Hrzjsh

ms,

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                    <text>h

,
l

.
~

October 10. 1966

Dr. Jonathan

0. Cole

National Bank Building
6917 Arlington Road
Bethesda, Maryland 20014
Dear Jonathan.

a...

..
.

VIVA.

nrnnm—uwmw-«nwvmo-my

r
w

“2—.

"I"

7???“um

Enclosed are couplets budgetary estimates
for the proposed study program “Quantitative

Studies.in Psychopharmacology“ (MH-lBBSE—Ol).
The salaries are consistent with those of
the College. as are the listed fringe benefit
components. I have estimated the first year

EEG

operation with some of the personnel beginning
at mid—year. and have added a machine operator
in the second year and an additional clerk in
the third. The program is planned so that by
the middle of the second year (1968). we will
have enough personnel to carry on a second
conputer shift, thus providing adequate facilities
for the service element of this proposal.
The program

director is identified as a

physician-neurophysiologist. The comuter
director will hopefully be someone with the
qualifications of Dr. Donald Shapiro.
Thank you for your consideration.
‘sincerely yours.

Fwy-1"

nm«rm.wg-ymw

:1m'—‘¥

was-w»

vmwr

.-

Max

Pink, M.D.

Professor of Psychiatry

Mskp

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                    <text>October 17 , 1966
Dr. Jonathan 0. Cole

National Bank Building
6917 Arlington Road
Bethesda, Maryland

20011;

Dear Jonathan,

is a preprint of a report which hasheen
. In
acceptedbytheAmhives ofGeneralP
we
wr
editorial,
an
te
suggest
addition, the J
t
Emlosed

and

I

am

enclom a copy of ﬂat editorial.

Iamlooking forwardtoseeingyoumay.

My

best regards.

Sincerely yours ,
Fink; M.D.
Professor of Psychiatry

Max

mka

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                    <text>October 20, 1966
Dr. Jonathan 0. Cole

National Bank Building
6917 Arlington Road

Bethesda, Maryland 200ll+

Dear Jonathan,

gives Dr. Itil and myself great pleasure to enclose
summary statement of the studies which have been undertaken at the Missouri Institute of Psychiatry during the past
eighteen months.

It

a short

As you know, not only are these studies clinical in mture,
but for most of them, the EEG and clinical laboratory data have
received Special attention. The report on trifluperidol is'
published and those on thiothixene and fluphenazine decanOate,
cycloserine, butaperazine and metronidazole are all in various
stages , with our expectation that they will be completed by the

end of the year.

thioridazine , chlordiazepoxide and combined
has been completed and the behavioral data analyzed. The
data is now being analyzed and when that is oanpleted, the
reports will be prepared.
C and
EEG

The study comparing
T

During the past few months in Missouri, studies on netronidazole,
(comparison with perphenazine), cyclazocine in depression,
and dilantin and thioridazine in adolescent behavior disorders have
been in progress. 'Ihese studies are under Dr. Itil's direct superP—5277

vision and responsibility. Part of the financial support of these
studies is caning from MH~ll$80 and 11381.
In New York, in part with the support of MH-12567, we are
studying cyclazocine in the treatrent of narcotic addition and
comparing it to methadone maintenance in the treatment of depressives.
These are clinical studies , although it is my hope that an EEG
laboratory will be established during the next few months.
Many thanks for your support and
continued collaboration.

we

look forward

Sincerely yours ,
Max

Fink,

mm M.

11:11, M.D.
'

mf kp

M.D.

to our

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                    <text>Novanbw 18 , 1966
Dr. Jonathan 0. Cole, Chief, PRB‘
Barlow Building
5145“ Wisconsin Avenue
Rom 10001

Chevyause, Maryland
Dear

deathan,

Imttoextemmythamcaforﬂnconﬁdenoeﬂutyw

mittees have expressed in supporting the transfer
oftmmmmmwmswymtothism
center. Widens are always diffimlt, and your support
and your

hasmadethismmdaeasierthanlradmpected.
Many

thanks.

Sincerely yams ,
Pink, H.D.
Professor of Psychiatry

Max

'

�</text>
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                    <text>December 1“, 1986
m". Jcnatl'an 0. Cole, 0110f, PR8
Bar-low Bui

505“ Wisconsin Avenue
Roan lOCol
Chevy (Ruse, Maryland

Dear Jonathan;
Dr.

utilize

Re:

Mil-12567

Nathan and I are writing to request pennissim to
to $800.00 for renovation

up
"

of the laboratory in the
of Narcotic Addiction." 'Ihis sum
will be deducted fmn the equipment assigmnt mcmtly approved,
and is made possibla by deferring some
of the equipmnt charges

to another project.
hemationswﬂlineludetmmingofadditional
doommdthebringinginofanelectricallm.
Thank you

for yam ooopemtion.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MP:kp

�</text>
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                    <text>March 10 , 1967
Dr. Jonathan 0. Cole, Chief, PRB
Barlow Building
SHSH Wisconsin Avenue
Room lOCOl

Chevy

Class, Maryland

Dear Jon,

It was indeed a pleasure to read the first report of the
collaborative depression study. That it confirmed our
observations of the antidepressant qualities of dﬂorpromazine
was most rewarding, for you surely recall the problem we faced
when we first proposed the study. I am most confident that the
definitive study will once again danonstrate the efficacy of
chlorprunazine.

That the combination was no better than chlorprmazine
I wrote Allen, our emphasis on
the combination may have historical mots and I am pleased

alone was surprising, but as

that the

your

new

study elaborated these facts.

Ilockforwardtothesucceedingrpports, andhopethat
staff will continue to share these "progress reports" of

the studies supported by the Clinical Oonmittee.
Sincerely yours ,

Fink,
m
Professor of Psychiatry
MOD.

MF:kp

�</text>
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                    <text>February 2a, 1967
Dr. Jenathan 0. 0019, Chief,

BarLow
SMSH

PRB

Building

Wisconsin Avenue

Fkxxn 10C01

Chevy Chase, Maryland

RE: MH~13358~01
anathan:
I am.writing once again with regard to the project
"Quantitative EEG Studies in Psychopharnecology.“ The initial
recruiting has gone well, and I have been able to use the funds
of MH~13003 in the interim, not having received an actual award
of this grant. IBM has indicated that they will be able to
deliver the 1800 earlier than I anticipated in the application,
with the delivery date now set for the first week in May.

Dear

Insofar as we have not had an award to date, and there
has been some delay in the expenditures, I am writing, with

the perndssion of the appropriate college authorities, that
the initial year of this project be started on April 1, 1967,
rather than the requested January 1 date. If this is possible,
the expenditures, bookkeeping, etc., will be facilitated.
Thank you

for your cooperation.
Sincerely yours,
Max

Fink,

M.D.

.Pttﬁessor of Psychiatry
,

‘MF:kp

Endorsement: This request
is approved.

MHEl3358-Ol

to delay the starting date of grant
FT Haydn

Morgan

Grant Administrator

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                    <text>April
Dr. Jonathan 0. Cole, Chief,

7,

1957

PRB

Barlow Building
5054 Wisconsin Avenue

Room 10COl

Chevy Chase, Maryland

Dear Dr. Cole:

I am writing to request a change in the approved budgetary
allocations for alterations and renovations and for equipment in
the program MEI-13358 , "Quantitative EEG Studies in Psychopharmaoology."
As you 1mm, we are establishing a digital oanputer facility and in
the project planning last summer, the engineers recommended some
partitions and changes in electrical wiring as the only renovation
costs. In anticipation of the delivery of the system during the
first week in May, the engineers again reviewed the site and found
that the air handling systems were inadequate to the needs of the
computer configuration requested. They have reconmended that a
.

supplementary

be

air handling,

installed before this

necessary room

coOling and dehumidification system
The

sumner.

total estimate for the
and air handling

modifications, electrical wiring

is estimated at

$8,000.

have also reviewed the equipment requests for this program
find that we have incorrectly estimated the needs during
the next eight months by $14,000.
Because the project has been delayed in its inception, there
funds
available in the personnel portion of this budget. We
are
are requesting, tpermission to 'reduce the personnel portion of the
budget by $10,000 and increase the equipment budget by $4,000 and
the allocation for alteration and renovation by $6 ,uoo. The proper
allocations following these transfers would be:
We

and we

.

ﬁrssgnj _%get

Personnel

$59,230

Equipment

28,000

Alterations

1,600

Change
$

.

Requested Allocation

-—

10,000

$08,830

‘+

0,000

32,000

+

6 ,H00

8

, 000

7

�'

Dr. Cole

-2—

April 7,

1967

Because of the necessity to have these engineering changes
before the swarm I an miting directly. As we have
discussed, I will submit within the next few days a total re—
allocation for the project period 1/1/67 through 12/31/70 for
Mil-13358 for your consideration, but the changes requested in
this letter will be included as stated here.

made

Thank you

for your help.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFﬂcp

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                    <text>“‘i
-l,

A

‘7va:

w

(~7f'n—-I:v,-‘Wrw&lt;uwi"fu-W

Juno 26 , 1967
Dr. Jonathan

0.,Cols, Chief,

Balm Building

Wisomsin Avenue
10cm

514514

Room

Chevy Chase,

PRB

,

.

mum
‘

Dear Jmathan,

It was with-sadmss and regret.
mam:

that I mceivodthe ammunce-

that yourm leaving NM. Since its inception as the

Psychoplurmacology Service Center, your leadership, tolerance
and patience has fostemd rmch of the psychopharmcology research

of the nation

«

indeed,

You mow, because

much

I

its biological

of

research in psychiatry.

earlier occasions

W.

have on

@cpmssed my

gratitude, that the research
at Hillside Hospital in' ECT,
EEG and in psycmtive
maimed
such of their support fm
We
PSC. The Missomo'. Institute of Psychiatry was also successfully
lamched primarily because

its programs in EEG

the,

of”

flexibility of Federal support,

trials-and chronic
schizopmenm were all basod on PSC Support. Indeed, we even
came to you for help in marching, am} were gratsful for your

and

assistance.

analysis,
_

r

new drug

'

'

.

Perms my greatest personal debt
NIMH

wasPin the Opportunity to
the Camnittee few Clinical Drug Evaluatim. It was
hemttatlsensedyourlesdershipbest~andlhthtthat
Committee will keenly fool the loss mment in your decision.

serve

on

So, for the record, pleass accepts}: personal thanks for
yew many considerations and your faith in the study programs
at Hillside (1956-62) and the Missouri Institute of Psychiatry
(1962-66) without which, the programs would lave failed.
Also, my very very best wishes for a successful career in Boston for if anyone can We changes in Samoan/ices, perhaps you can.
—-

.

My

best personal regards.
Sincerély yours ,

,

1‘41”}qu

7‘

cc: Dr. S. Yolles

sax Fink, 2w.
Professor of Psychiawy

�</text>
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                    <text>5

I

.

”viva”,

.VV._;.,.,.,.

3......

{Yr—”u...

,..,

u,

»

June 20, 1967

u

w“...-

wwmmm

&lt;-

vw-v—wn

Dr. Jmsthan 0. Cole, Chief, PR3
Barlow Building
Avenue
susu

Wimin

Room 10C01

Chevy Chem, Maryland

Dear Jonathan,

I

'

as: Isl-1256742

-

uniting to request your permission for the allocation
to $3, 700 from Mil—12567 to support special animal
pharmacology studies of cyolazocine by Dr. Richard P. Irmite of
the University of Termssee.
am

of fmds
The

up

clinical studies with cyclszocine in the treatment

of narcotic

addicts have

gone

very well.

The

initial studies

denomtmted a satisfactory dosage schedule and we are new
cyolazocine oxgmizing the comparative rs‘ndm
methadone transients in volunteer narcotic addicts.
Concmmntly, our

EEG

assth

studies demonstrated a spectrum of

activity similar to imiprsmine and a clinical stung of cyclasooine
in the
of depression undertaken in St. mum. The
results of the first eleven depressive patients are being presented at the Montreal ECDEU meetings, and mess demnstrste
clearly that Cyclezocins has antiéspressant activity. At the
same time, we have hem studies in the Mental Hygiene Clinic
at Metropolitan Ibsﬁitel and these too are showing unusual
clinical results.

mm

"

Under project WI~13358, the EEG latmtory in New York is
re-established for quantitative analysis and I am devoting
the next few mnths to an intensive analysis of the dose response
of cyclazooine and heroin in postmamotic addicts.
The animal studies of heroin and cyclszocine are very limited.
Dr. Richard P. Emits of the University of Temessse, a. sophisticated
aminel phamecologist, with a sincere interest in EEG, has indicated
that he would be willing to carry out some additional studies in
his laboratory during the next's to 12 months. He has some time
available because the proposed sabbatical in England has been
deferred for one year since Dr. Bradley is to he may in Palo Alto.

m

�:a4
law)

1...,

-

4v»

~

-.-

m“. Cole

A

A

~2-

June 20, 1967

-‘
,

My”...

.4“

...,_

"Wu—v”;

-.1—wwvmp—g-.~

After some discussion, Dr. White has submitted the attached
protocol and has indicated that these studies could be supported
by a budget of $3,700. This own is available in the present
grant by the transfer of personnel costs to our clinical funds .
Dr. Preednan has concurred in them mmndations.
Play we

have your approval for the allocation of funds up

to $3,700 from I‘m—12567 for consultationtfees to Dr. Richard P.
White of the University of Tennessee in line with the attached
protocol?

‘4

"&lt;

V-

Many

‘

-

z-r

'

;

thanks for your assistance.
Sincerely yours ,

:v“?-w-&lt;".

.

pmwmmwwxlquv-m

Pink, M.D.
Professor of Psychiatry

Max,

MF':kp

cc: Dr. White

'

zen":

W'Wwa

aammawww.

15v

".79.".

-;

n

u»

.r.

uranwm.

-».-

..
,

u
.

rmrw4lr-luﬁi

�</text>
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              <elementText elementTextId="28482">
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                    <text>may 23, 1967

Dr. Jonathan 0. Cole; Chief,
;

Barlow Building

susu Wisconsin

Room lOCOl

Tynan—w-

Akue
,

Chevy Chase, Maryland

"lwﬂ‘l

PRB

'

__

Deer Jonathan ,

1er

I

am

taking the liberty of writing regarding a proposed

the subject of ”EEG and Hanan Psycmpharmoology"
or "EEG and mm: Behavior" for the forthcoming CINP meetings
in Spain in 1958'. A symposium on this subject was held on the
occasion of the World Congress of Psychiatry in 1961. This
reviewed the methods and experiences then available and indicated
that there were interesting relationships between EEG and drug
symposimn on

effects but that the methods were relatively poor.
Since then, two major symposia rave been held

.

and published
(Glaser - Yale UniVersity, 1963; Wilson Duke University, 1965).
Also, there have been two major discussions of the problem of
dissociation of EEG and behavior with antioholinergic drugs, at
the, Society of Biological Psychiatry (1965) andthe CINP (1966).
—-.

‘

Recent studies of more refimd objective methods of
quantification has enhanced these studies mmssurably. The
enthusiastic interest in the relation of the EEG phases of
sleep to behavior and to drug effects have also stimulated

my new

studies.

The spectrum

is broad,

.

of relationships of

enoanpessing the

EEG, drugs and

behavior

specificity of'drug effects, the
relation to diagnosis and the relation to treatment response.
I would like to ask the Program Committee of the 1968 CINP’ to
consider

an all~day symposiwn on the subject "EEG and Human
Psychoplnrmacology. " I would be pleased to- organize and chair
such a smposimn.
'

'

Sinceme yours ,
wi'f‘

.:

'r'

wwm-W‘Z.‘

"new

wavin-

-,

Mex

Fink} M.D.

Professor of .Psychaitzy
MF:kp

�</text>
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                    <text>May 23 ,

Dr. Jonathan 0. Cole, Chief,
Barlow Building,
5050 Wisconsin Avenue
Roan 10601
Chevy muse, Marylam

Dear Dr. Cole:

1987

PR8

RE: MEI-13358

It is with considerable satisfaction that I report our meant
progress in the study program "Quantitative Em Sonics in Psycho—
phcrmaoology," Lawn—113353,. and mquest your comidcmtim of
a revision of the total budget period, not only for 1967 but for
the full grunt period - Jammy l, 1967 tlmmgh Dooonbcr 31, 1970.
Dining

this initial year of transfer of the study program
New York, I love boon fortunate in being able

firm Misacmri to

to make the initial staff appoinhmmsa under the mlmntaxy
grant 14143003 and owing the minder of 1967 will need mob
loss in pummel funds. As you
transfers frcm personnel
into the equipment, alteration and renovation categories have
been appmvcd; Attached is a revised budget allocation plan for
the minder of tin study period mick follows closely the
original application, but which takes into aocmmt mo realistic
estimates of our needs in this now Institution.

m,

'mcm am no changes in

xuu-v

*2:th

may of the restricted omega-mics of
and mmvatim except that the
alteration
travel
oquiprmt,
or
allowance of $0,000 in 1969
a.
estimate
wacvctim
of
original
has been inmascd to $8,000 and an additional allowance of $4,000
is mqucsted in 1970. It is our expectation that we will be
movingtothencwcamnmityﬁmtalﬂcalthccntermwmnear
the end of 1969 and I on certain that mmvationa will be mceoomy
to provide my satisfactory air Mndling and electrical oomcctions
for this study program.
Mother major change is in the allowances for omputor rental.
The origiml Midgets mm prodioatod on our processing the rating
scale data using optical page readers. The Director of the Gonputer
facilities of the New York Medical Collage and an active participmt
in this program, Dr. Donald Miro, has recently indicated that we
‘

‘

A

wouldbebettcrscmdtouscdigitaloscilloocopctominclaand
$1me links to the 134-1800. For this mason, we are rebudgeting

—
A

“v,

""1531?“

mute-r mtal costs.

�1“,”.sz

no

.

~2~

Dr. Cole

May

23, 1967

vmrwnhv

W.“

7-“

4..v,.,.,..-.,~

‘

year period is identical
March 8, 1967.
dated
with that married in the notice of grant
The

total

amount mannered

for the

4

Thereallomtimoffmdamquestadmbwnapprwedby

-v.

ﬂmEmmtiveDimctoroftMDeWtofPsychiatwmdthe
I”.
Morgan.

Vice Preaidezrt of Research

Mminiamtim,

Haydn

"Aw-4.1.,

”‘WW‘“

Many

thanks.
Sincerely yams,

ermvmryom:

.5-

&lt;

Fink, Md).
Professor of Psychiatry

Max

,,

t
‘

a

1'1?sz

.g

.nr‘,

wh'wrwvuz.w-r-M=u~mwznu.

‘

Approved :

"P.

Haydn Morgan, Vice

Research

A,

Wﬁu‘rwra’x‘y‘

Pl"!

W'W-WWW"‘WJW.TQ1WWWMV-)

’
«

Pmaidem

Mninistmtim.

�</text>
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                    <text>May

2, 1967

Dr. Jonathan 0. Cole, Cl'xief, PRB
Barlow Building
susu Wisconsin Avenue

Room lOCOl

Chevy Chase, Maryland

Dear Dr. Cole:
Under the grant MEI-12567 "Pharmacotherapy of Narcotic
Addiction" and with funds for equipment which are already
available, we would like permission to purchase a Priden
desk calculator with square root and automatic decimal
control, to assist us in processing the cyclazocine and
other psychophazmcological data. May we have permission

to allocate $1,695 of approved equipment funds for this

purpose-

-

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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July

26 , 1967

Dr. Jomtlmn 0. Cole, Chief, PR8

Barlw Building

5454 Wisconsin Avenue
10001
Chevy Chasm, Myland 20203

Room

Dear Jmatlmn,

far your favorable consideration of
the depmssion~ cynlazocine study. Allen338 letter was most
helpful and I did contact time of the four investigators.
I foxmd that the tion schedules were an varied that no
session was possi 1e before ear-1y Septmber. I have notified
Dr. Bird and would like to wait until after Labor Day to
contact you and the other investigators again to see if a
Irma suitable date can be arranged.
Thank you very xmch

I We the transition to Boston ﬁnes easily.
Sincerely yours ,
Fink, M.D.
Professor of Paychiahy

Max

Wtkp

�</text>
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                    <text>‘M’u":

u

January l0. l968

wrw.

Irv“

Dr. Jonathan 0. Cole

Boston State Hospital
Boston. Massachusetts
Deer Jonathan,

It gives me great pleasure to invite you to participate
in a series of resident seminars in psychopharmecology at the
New York Medical College on March l5. The seminars are held
at the Metropolitan Hospital (97th Street and First Avenue)
in the conference room on the l5th floor. at ll:00 a.m.
I am enclosing a listing of the seminar titles and we
would be pleased to have you discuss the clinical antidepressants.
he

our

I

will defray your expenses and there will be an honorarium.
will call you before March l5. Thank you for accepting

invitation.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April 18. 1968
Dr. Jonathan 0. Cole

Superintendent
Ecston State Hospital

Boston, Massachusetts 02124
Dear Jonathan,

Enclosed

visit to the

is

a check for your expenses in your eecent
Medical College. Again, my thanks.

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatny

Max

MF:kp

enc.

�</text>
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                    <text>April 8, 1968
Dr. Jonathan 0. Cole

Superintendent

~

Boston State Hospital
Boston. MasSachusetts 02l24
,

Dear Jonathan.

invitation to discuss convulsive therapy with the

Your

residents has inspired
the citations that

me

I would

to review my files and to consider
suggest for background reading.

The best texts are those of Kalinowsky and Hoch (Somatic
Treatments in Psychiatry. Grune and Stratton, l96l) and

..

-

.

'7'

.r~--¢.m.w.-1.;,

_,,

Sargent and Slater (An Introduction to Physical Methods of
Treatment in Psychiatry. williams and Wilkins. l964).

is a list of citations which assess some of the
in convulsive therapy. The list is not
issues
important
exhausted and I have selected the article for clarity. No
Attached

effort has

been made

to

be complete.

I am sending you xerox copies of each of the
this may be useful for the residents.

Separately,

articles

and

I plan to arrive at your hospital about 10:30 a.m. and
would be pleased to spend some time with Dr. Hartmann.
Your comments about the review of EEG and drugs are cogent.
0n reureading I agree that this is too much of a summary and a
longer version should be prepared. I would like to discuss
this with you when I am in Boston.
I look forward

to seeing

you next Wednesday.

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>a, new. a—
-

August 16, l968
Dr. Jonathan 0. Cole

Superintendent
Boston State Hospital

Boston, Massachusetts 02l24
Dear Jon,

Enclosed are the initial reports on cyclazocine as
an antidepressant as submitted for publication to Dr. Braceland.
This suggestive confirmation of the EEG predictor model for
psychoactive drugs has stimulated ongoing studies of doxepinc.
Al

Perhaps you

DiMascio.
My

may

wish to share these reports with

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kp

enc .

�</text>
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                    <text>January 8, 1969
Dear Jonathan,
La may be intarested in carrying
of offspring to schizophrenic mothers.
of
the
sex
studies
out concurrent
and a praprint of the report aub~
ch:
article
am
original
I
enclosing
minted to Science. An additional raport 05 the problem of poat~partum

I

am

pleaaad that Dr.

psychoais and the offagring sex is being typed and will be sent to you

shortly.

my

best regards.

E

Sincerely yours,
Mn: Fink, M.D.

Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ﬁasa. 02124

�</text>
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wr'

pvv

w.

—u-.--«.yv

WWW&lt;

April 23. 1969
Dr. Jonathan 0. Cole
Superintendent
Boston State Hospital

Boston, Massachusetts 02124
Bear Jonathan,
I am very

very grateful for your enthusiastic

letter

regarding the ECT Manual. Your request for so many copies
and your suggestion that it be published led me to review
the manual and I have made a few modifications. particularly
in the theoretical sections. This is being typed and I am
going to submit it to the American Journal of Psychiatry, hoping
that they will accept their educational Tbnction.
which

In the meantime, I will arrange to run off 50 copies
be sent to you within the next few weeks for

will

distribution to your staff.

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

Mszp

�</text>
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                    <text>March

l3, I969

Dr. Jona‘l’han 0. Cole

Superlnfendanf
Stale Hospllal

Bosfon

Bosfon, Massachuseffs 02l24
Dear Jonathan,
The speclflcaflon of magnellc tape system described by
Ernesl Harfmann ls compaflble wlfh our SP-SOO, for recordlngs
made a? 7 l/2, 3 3/4 and l 7/8 Inches per second recordlng

speed. These speeds are Idenflcal fo fhose available to us.

3

The maJorlfy of our lapes are recorded a?

3/4 lps.

lee

Ernesf

my

l

7/8 and

has? regards.

Slnceraly yours,
Max Flnk, M.D.
Professor of Psychiatry

Mkap

�</text>
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                    <text>W‘

waver”.

‘

,

,

-

V

‘1',

March 1:, 1969

Dr. Jamathan 0. Cole
Superintamlem:
Boston State Hospital
Boston, Nasaadmsetts 021%

Sear Jmathan,

mud

ﬂue
kind 911mg}: to
been.
This
has
canvulaive
ﬂ'larapy.
new for a manual of
cqnplataa and I am enclosing acme copies for ymr use. If
to make whatawr
it is aatisfactm, we amid be pleased
max-ants are necessary to run off my copies you may

may

mmﬂ'za ago you were

need .

a mthesiologist who is able to
Mt
manage complex convulsive therapy cases. I would mcmnj
You asked

W. Frank

22.

Wmn,

(212 875-5636).

I trust this

W6 East 88th

manual

Street,

New

York,

is Emlpful.
Sincerely ycnm,
Max

-

.
-

"HV‘V'T

MI?
V-IWJAz-n'

m“

A

7-m'rrf4

an...-

,.
...

my...»

at.

mme.w

wmmmmwzw

.,

Fink,

£41.13.

Mfeasor of Paydliatry

m-w

:kp

New

York,

v

FW/Jv'wnz-uyuw Jul-In~

W

�</text>
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                    <text>-.

-

,V,-

m

”mi—Viv”,

w.

Mltch 8, 1970
Dear Jon,

Yoatotduy. I met woth my local Congressman, Lasts:
Woiit, and discussed the Kongo bill transferring control of
rasoareh to the Justice Department. He was most oympathotic
and askod if the boat approach might not be to hold hoarings in
Raw York. on the basis of tho bill, to describe the present
efforto in drug reaoaroh.
This may have been a

'put~off'. but

he seemed

sincere

(are thoy not alwaya ?) and askod that I lend him some additional
data. I left the tootimony you gave mecwith him, and promised
to send additional.

material

list

Plooae add his name to the mailing

on the

bill:

of any direct

Hr. Lester Wolff, Coagrosnnln
156A Kain

Street

Port whohingtoo,
Many

Now

York

thanks.
Sincerely yours,
Max

P.5. I look forward to seoing you in

Fink,

ﬂow York

M.D.

Friday.

�</text>
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                    <text>April

10 , 1970

Dr. Jonathan 0. Cole

Boston State H05pital
Boston, Massachusetts 02129
Dear Jon,

After your telephone call, I asked Dr. Volnvka to check
on the question of hyperbnric oxygen and EEG, and the following
are his notes:

literature deals basically with two aspects of the
problem: oxygen convulsions and the therapeutic use of hyperbaric oxygen. The most recent work on convulsions (Morel,
Kerom and Levy, 1969), apart from asserting that the seizures
have a random origin (at least in the rabbit), also provides a
useful survey of the older literature.
The

Therapeutic hyperbaric oxygen effects on

were reported
by Levy-Alcover gt 31;, (1965), Marinchescu and Poilici (1966),
and Goulon et alt (1968). In patients with cerebrovascular
diseases, hyﬁergaric oxygen caused widely heterogeneous EEG
changes (either some flattening, or an amplitude increase, or
sharp elements) and this was interpreted as indicating that
oxygen might have resulted in cerebral vasoconstriction in some
cases. This would have accentuated any pro-existing hypoxia.
EEG

In London,iin 1966, a heterogeneous group of neurological
patients convalescing from brain anoxia or injury were introduced
in a hyperbaric chamber. I reviewed the records of 5 patients
and in this inadequate couple, saw changes reminiscent of the
initial stages of sleep ~ a lower of amplitude and slowing of
dominant frequency .

�Dr. Cole

The

April 10,

~2—

1970

references are:

Harel, D., Kerem, D. and Levy, S. The influence of
high oxygen pressure on the electrical activity of the brain.
Electroenceph. clin. Neurophysiol., 26: 310—317, 1969.
Dordain,

G.

Goulon, M., Levy-Alcover, M., Nouailhat, F. and
The BBC

clin. NeuroPhysiol.,

in hyperbaric oxygen therapy.
25: 90, 1968.

Electroencephl

Levy-Alcover, M., Goulon, M., Nouailhat, F. and Augustin, P.
of
study
patients undergoing hyperbaric oxygen therapy: first results.
Electroenceph. clin. Neurophysiol., 19: 608, 1965.
EEG

the

Marinchescu, C. and Poilici, I. ﬂyperoxic effects on
background activity in cerebrovascular diseases. Electroenceph.
Neurophysiol., 21: 95, 1966.

EEG

clin.

I

trust this is helpful.
Q

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>« «aw—Wm “‘"1H-3y»

"

‘“

‘

~‘

'“"‘

"*‘V‘rvr-ﬁ~é“r*~"'v--*"’r"

‘&amp;

'W

--u.—.

‘w

&amp;n~‘1-Ir:"'.9¢'~‘-WH-

,

,-&lt;.v—w.‘:r.-m-~«M. EEW'rv—W' u.‘

,7

.
.n
._..r....r....r‘....-,.~-..,..;..-,v..‘..._._.,..(n
.
_

v

..._.

.

~

.,
.

1

«a.H

,
w
hm . w . 'ry4.‘.::,
.rn.‘ -1...“
,

,

June 27, 1970
Dr. Jonathan 0. Cole, M.D.
Boston State Hospital

Boston, Massachusetts
Dear Jon,

It is a pleasure to respond to your questions of the
of
to recognize heroin and to distinguish its
post—addicts
ability
effects from other compounds. Our data may indeed be relevant.
In a variety of studies, we have administered heroin
(15 to 25 mg/icc/Z minutes), saline, cyclazocine (0.2 to 1.0 mg/Z cc/
2 minutes) and naloxone (0.4 to 1.8 mg/Z cc/2 minutes) to post-addicts
(3—20 days after last doses of methadone) and to subjects receiving
chronic oral methadone (100, 150 and 200 mg] oral/day).

addicts, between 20 and 35 years
of age, with histories of opiate use for at least 2 years. Our sample
consists of 35% Puerto Rican and 50% negro. They are voluntary admissions
to Metropolitan Hospital and their cooperation is obtained for these
experiments by indicating that these teats are necessary as prerequisites
to chronic maintenance therapies with cyclarocine or methadone.
The studies have been in progress for 4 years, add in this
time we have examined more than 100 subjects in more than 400 experiments.
The

subjects are

young male

Based on this experience, I believe the following conclusions
are applicable to your questions.
1. Can addicts recognize heroin, given intravenously and

double blind?

Post-addicts have no difficulty in immediately identifying
They make occasional eraors with 15 mg, indicating a
difficulty in positively identifying this quantity. They identify
cyclazocine as a noneopiate substance, and naloxone has always been
called a 'blank'.
25 mg

.
"urn—rmri

«mo-a-

heroin.

..
—,

u:

vl—‘W'I-r-u‘,"

Am

..

-;~,-.

‘.‘;-W'V!

«ﬂy-1.

r-p

.4.

,.

any“...

'Ivnr'i’vw

1

-

Subjects receiving 100-200 mg methadone daily, cannot
identify 25,50, and 75 mg heroin for up to 48 hours; thereafter they
rapidly identify the small doses of heroin, not only by direct heroin

effects, but

hours.

by the

relief of

withdrawal which

is present about

48-60

,
«Yo—am.

an.“

:y:

u--.“

.m

:

�For post-addicts and methadone subjects after 60 hours,
the administration of heroin is accompanied by a sequence of experiences
described in such a ritualistic fashion as to make us believe that the
effects are commonly experienced. The subjects are tense as the injection
is first made, and after 1.0 to 1.5 cc, they relax, smile, and tell us
that this 'is it': they feel warm 'all over'; and within 2-3 minutes,
are comfortable, drowsy, cooperative and tell us that they are 'high'.
u

,umv

—~

—,

sequence

is

no good', and do not become drowsy.

‘Arw¢v.4w1v‘m~4rv—|

r

is

a placebo, nsloxone, or cyclazocine are given, this
not apparent. They remain tense, complain that the 'stuff
When

our

For the patients who have had morphine, they tell us that
does not feel like morphine since they lack the skin tingling

stuff
is characteristic of morphine.

which

I would conclude, that addicts can tell 'good stuff' from
The amount necessary in our subjects is 20-25 mg. (The
clinical effects are accompanied by characteristic EEG changes; and in
the methadone treated subjects, bedore 48 hours, the EEG effects are
indeed absent, as are the behavioral effects).

the effects.

2. Our addicts can discriminate heroin from the substances
above.
They can also tell heroin from alcohol and barbiturates,
indicated
am
if I to believe their reports, but we have never made direct experiments
along these lines.

v‘

r

m'wmm

r
w.

.un'-q-I

u

.

distinguish

I have never tested the ability of our subbects to

among

I
specific
posed them, I
may be useful

have

While I do not
data to answer the questions posed in the way you
will send the reprints and preprints available, and these

I‘M/r.

If

mr'

mumpwr

-

opiates.

trust these responses are helpful.

in supporting your evidence.

it

your presentation.

is of

any help,

we

can be

available to support

/:u4-w~

A"..W5w31r.lp'-

best regards, and I do appreciate the Opportunity to
answer these interesting questions.
My

«-

w

xv

,
‘mm

Sincerely yours,

v”:

'A

vvw—w

JD'WﬂI'W

Fink, M.D.
Professor of Psychiatry

Max

yam-v

ov-nrw'wnrvv

.
nun-s.

n

-..
‘
~

”army-n:

mf/

�r Zwm'jiﬁhzx'n» ”w“

.

.p—

--. -mpmmu

,

as.

.,_.,.

June 24, 1970
Dear Costas,

Finally, I have very good news ! During the past
month, the grants management staff of the N.I. M. B. have met
with me on three occasions; each time we resolved another problem
and today, they signed a contract allowing us to undertake the
study we discussed more than 15 months ago. The problem of
cannabis is still acute, and despite many new studies, there is

still

confusioin about the possibility of chronic effects.

The contract permits the International Association
subcontract
with
scientists in Athens to study the problem
to
of the chronic effects on brain function and behavior of cannabis.
The goal is to study as many men as may be found who have been
taking cannabis regularly for extended periods; to measure the
degree to which brain dysfunction may have occurred; to undertake
acute experiemnts, in which the EEG, memory and perceptual changes
of cannabis smoking may have an effect and to record the changes,
with analyses completed in Athens or in New York. We are also hoping
to have supplies of cannabis from the men themselves, with portions
smoked and others analyzed in your laboratory. In addition, we
are permitted to ask that some THC be extracted and tested in
these clinical trials.

I do not know how much can be done. The original
been
has
accepted, with few modifications. It seems
protocol
best that I arrange to meet with you during my forthcoming trip
to Europa, and that a more definitive protocol be worked out;

particularly one in
proper

staff

which the work

is detailed

so

that the

can be recruited and a work schedule prepared.

Dr. Freedman will also be in Europe this August
and I hope that he will have an opportunity to meet with you
and discuss his goals for this project. Unfortunately, I do
not think I will be in Athens at the time he may be available.
As my

plans

now

stand, I will attend the Turkish
in Athens from

C.N. P. meetings from August 17 to 21, and can be
the afternoon of August 21 for the next few days.

If that is

not satisfactory, I could take my family to Israel for
and arrive in Athens August 25-27.

some days

We

look forward to working with you, Dr. Stefania

My

best personal regards.

respective associates. I hope that we will be able
contribution to the definition of the problem of
the effects of cannabis.

and your

to make a

Sincerely yours,
Max

Fink,

M.D.

�</text>
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won.

waxwrvvm-u-wa-w»—rmw-y—m:mxmmvmmwAWN:

.

'

V
.

'

'

r

,

rmwvww-w

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.

..

,

«mm.

,

"\mw‘WN-«hﬂvar'N-o-HIW

November 5, 1970

Dr. Jonathan 0? Cole

Boston State H08pita1
Boston, Massachusetts

Dear Jon,

Just a letter of appreciation for your efforts on behalf
Americans in achieving a better drug abuse control law. I have
read the Congressional Record and the final bill, and believe that
the differences from the January bill are significant—— much of
it due to the efforts of the Committee I presume.

of

all

I trust that the Committee will not disband
skirmish seems to have been won, but will continue.
Many

now

thanks.
Sincerely yours,
Max

Fink,

M.D.

that a

�</text>
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                    <text>“WVWVIM'“"-—7"MV1YV‘$W"W- -.

ms '7‘?

ww-n—v.

',’n:‘~ .maqm.:

‘wm

-

~

wear-w...“

NW.,.

4... ,.,,.

mm,

,.

"H“.

...../,.....‘.,.

.

..

..

January 15, 1971
Dr. Jonathan 0. Cole

Superintendent

Boston State Hospital
Boston, Massachusetts 02124
Dear Jon,

It

pleasure meeting with the editors of Semina&amp;6.£n
I was most heartened
It was an impressive group, and do
and
enthusiasm.
I
not recall being
discussion
frank
by their
and
perhaps I under—
a
for
such
talented
many
a
group
among
year,
excitement
in Boston.
the
for
of
the
some
stand
reason
part
was a

Psychiazng.

to the project, I understand I should proceed to invite
reports reflecting the recent research findings in ECT, focussed
on the topics listed in the attached memo. we should set a target
date for manuscripts of August 1, for you by November 1, with
approximately 200 pages of typencript.
As

In addition to the research topics,

we

should

solicit

a

clinical section, preferably in Q. and A. form to satisfy the
more directly practical questions. This should encompass about
15-20% the text. There may also be a theoretic overview to review
the theories of the mode of action of ECT and suggestions as to
research needs.
and

Please review the attached

suhjects.
Some

list

of potential contributors

technical questions.
(1)

Is there a budget for a fee for contributors?

(2) We have an MT~8T and if we retype the texts, the
made available. For some publishers this is a distinct
be
tapes may

saving. Is
technique?

it

(3)

for

Grune and

I! there

Stratton,

a budget

and

shall

we

plan on this

for secretarial (editing) expenses?

�~2~

Dr. Cole

January 15, 1971

While I understand the copyright will accrue to the
and
the probability of royalties slim for the journal
publisher,
do
believe we should negotiate an understanding regarding
edition, I
royalties in the event the issue is highly successful and in reissued in soft—cover and in hard cover ~ particularly the latter.
I am sure you already have a standard agreement and this should
(A)

be reviewed.

What happened

in

Dartmouth?

In the rush I forgot to ask.

If you're not interested, I an.
Expenses for the trip on Monday were air fare ($52.00) and
ground ($14.25) for a total of $66.25.
Thanks again for the invitation to contribute to Seminars.
Sincerely yoora.
Fink, M.D.
Professor of Psychiatry

Max

Hszt

�</text>
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                    <text>Batch 19, 1971
Dr. Jonathan 0. Cole

Superintendent
State Hospital

Boaton

Boston, Massachusetts
Dear Jon,

Peter Irwin and Nick Pavel visited 383 on Tuesday. They
reviewed the recording methods and recalibrated the equipment,
so that other records will be analyzable with ease.
Enclosed are the transportation stubs.
If not, will cover with our funds.

thanks.

my

If payable,

many

best regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

MFA“:

one .

�</text>
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                    <text>March 5, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, Massachusetts
Dear Jon,

It was kind of you to recommend our studios in marijuana
to Dr. vanPraag. I am.tak1ng the liberty of enclosing summaries
of our recent reports for your information.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>1"

‘

June 29, 1971
Dr. Jonathan 0. Cole

Superintendent

Boston State Hospital
Boston, Massachusetts 02124
Dear Don,

In l96h665, in St. Louie, Turen and I studied the effects of
thioridaaine (5 mg/kg), chlordiazepoxide (1 mg/kg), each alane; and
thioridazine (2.5 mg/kg) and chlordiezepoxide (0.5 ng/kg) combined

in a croseover design in 24 chronic schizophrenics. Dosages were
maintained for 8 weeks and there was a placebo period of 8 weeks
between each dosage.
The

clinical effects have been published,

as anticipated.

and the findings were

In the EKG, BR, EP and hemogram data, we found consistent
changes with thioridazine alone or combined, and not with

chlordiezepoxide.
The

was

EKG

changes were not striking to me, but the consistency
age of the subjects.

related to the

In the next years, Turan studied high dose fluphenazine and
butaperazine and with both drugs, found similar EKG changes but

significantly less frequently.

In my hands, there are no differences in clinical activity
between thioridazine, fluphenazine and butaperazdne. Since fluphenazine
exists in 4 different formulations, has a very high therapeutic/safety
margin (doses fro: 20 to 1200 mg have been given by us), and induces
little or no EKG changes, I see no Justification for continuing the
use of thioridazine (ace Ban, pg. 150).

�,ww

Dr. Cole

June 29, 1971

~2~

Similarly, I

wonder about the very rapid approval by the FDA
of meeoridazine, a sister compound, for which seemingly excessive
claims have been made (in therapy of alcoholism and anxiety). In
the Sande: date, the EKG changes are said to be equal to thioridexine.

So, my view for both compounds is tempered by the variety of
antipsychotic drugs available, and the suggestion of greater effects
on the EKG. Since I cannot fairly judge the significance of these

effects, being unwilling to

deny them, and attempting prudence, I

that the use of thioridezine be limited to those
specially trained in psychopharmacology for research purposes.

have recommended

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
HF:kt

�</text>
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                    <text>June 17, 1971
Dr. Jonathan 01 Cole
Boston State Hospital

Boston, Massachusetts 02146
Dear Jon,

Enclosed is an abstract (5 copies) for your consideration
for the 1972 APRA under the sub~group "Drugs and Brain Function
relevant to psychopharmncology."

Sincerely yours,
Fink, M.B.
Professor of Psychiatry

Max

�</text>
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                    <text>w Hwy-«M

"V‘r‘" &lt;--

‘Vw

V

May 13 ,

1971

Dr. Jonathan 0. Cole
Boston State Hospital
591 Morton

Street

Boston. Massachusetts 0212‘
Dear Jon,

I am pleased to enclose 3 conies of our report, ”EEG Pcofiles
of Fenfluramine. Amoberbital and Dextroamphetamioe in Normal
Volunteers” for your consideration for Foyohopharmacolagia.
we have actually carried out more analyses with.oimilar
results, so that
the details reported here are a part of our data. Nevertheless,
the figures (6) may be too many and we can reduce these to 3 (1-3 only)
if space is e consideration.
This represents the first of our detailed reports, and I would
be honored to have it appear in Phychopharmaoologia. since without
your encouragement, the program would not have developed.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>r.“ wx-n-c-Wrnvm

~mmrw-mwm- rm

n

W‘wm'vﬁv-v'm‘r-

J wmanmwuxmm

,

"nu--

-

,

,

,

'"W'\tvv~&lt;- .—v..mi—..-w-.~.-

...—..,.,._..m~_r....r_..

W,

-v
_

..

.

v

V.’

-.

,-

w

w."

,WWFrymw.—uwmn

tar-vmmrrww-

July 22, 1971

u-w-n—v-

vr-v

mum—mum”

Dr. Jonathan 0. Cole
Managing Editor

Psychopharmacologia

m.

W,"

uwmwﬂw

.

V-A'Wi-WMWIVV'F‘WWW-

Dear Jon,
With reference to manuscript A—785, 'EFG Profiles of
Fenfluramine, Amobarbital and Dextroamphetamine in Normal
Volunteers', I would suggest the following key words:

EEG,Quantitative
Fenfluramine
Drug

Classification

Volunteers

Amobarbital

Dextroamphetamine

W"W"E’ﬂmv«m‘mm‘wm¢r'

My

thanks for your consideration of

this report.

Sincerely yours,
Max

Fink,

M.D.

was

ww’rrr'

m—

Iwm maazww P‘W-WWK

7.an

�</text>
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                    <text>July 6, 1971
Dr. Jonathan U. Cole

Boston State dospitel
Boston, Massachusetts
Dear Jon,
Don Shapiro and I have reviewed the comments on our report,
“EEG Profiles of Fenfluraninc, Amobarbital and Dextroamphetsmine

in Normal Volunteers“ (Ar785), and thank you for them.
The figures do represent our data as well as we have found,
but the reviewer may be correct in asking that the ordinate be

clarified.
be

better

Would "Standard Score Based on Pre~Drug Mean and Sigma"
than “Difference from Pre~Medicstion Mean”? If this is

better, the printer

can change these

in the glossy prints in the

will have the figures remcaptioned.

original; or, we
I believe Table 11 does show something better than the text,
and I would like it published.
"Your comments on page 5 are most helpful. We have rewritten
the paragraph, and have inserted a corrected page 5.
The second reviewer asked about order effects for fenflursmins
when it was introduced st.the end of the series in some subjects.
We examined our data for order e~fects and found none for drugs, but
did for differences in the first records from subsequent records
(pg. 7). The first session effect (similar to the first night
effect in sleep EEG research) was accounted for, however, by the
random drug assignment.

of female subjects was a problem. we found that the
women (due to the
variability of prs~drug records was higher in and
male
this observation
subjects,
menstrual cycle?) then in our
of child
woman
in
plus our reluctance to use experimental drugs
experiment.
since
this
males
only
bearing age has led to our use of
some
BBC
by
sex
except
differencss
We do not have any data on
adequate
and
not
is
this
suggestions that females are more variable,
Our use

for publication.

�“v.1:

m...“

v

“we-"

A—

pnmw‘xw‘m—r.

—.'

'n'l"

WW

w'l‘w—m

1
www—

w

"—I-v—wvm-w-w-r

r...

.__..,—yv

-2-

Dr. Cole

Finally, the

speculation and

I thank

you

mechanism of

July 6, 1971

action of fenfluramine is

is of great interest.
for your

support of our programs.

prompt

consideration,

and

for your continued

Please advise as to the figures.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
enc .

a matter of

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                    <text>rW

WW

__

_

WWW WWWWWWWWWWWV-.- WW -

October 14, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ¥assachusetts
Dear Jon,

Previously, I sent the reports by Small &amp; Small and
Dornbush. The Essman report was returned, and has been re-edited.
Enclosed are two copies each of the Abrams and the
reports. The Essman paper is better, but if it still is
unsatisfactory, please do not hesitate to edit it. I have
asked him to send me the glossy prints for his two figures and'
these will be sent with the next batch.

Essman

The reports by Volavka, Fink, and the Q 8 A are
in their final typing and should be done by Friday or Saturday.
I am distressed only about the section by Pitta-- he had promised
it two weeks ago and when I called him on Monday, he said it had been
mailed. Lost ? I hope not-- but he promised to send me another.

use, which

There

will

It

is also

an

come with the

introduction that I wrote for your

next batch.

has been fun, and I hope the texts are

satisfactory.

Sincerely yours,
Max

P.S. I cannot be sure-- did you ask
Dornbush and Smalls' reports 7

me

Fink, M.D.

to send you duplicates of the

�</text>
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                    <text>—

_,.,

,

7-»

W-.ww aw

~~..r.—w—~—~-...ﬂ

-

mr cup-u .v-q—

w—.

v”

.-,

,,

..._ l...

,

._

,

w

.0“

v

.7

.

W.

.

4‘.

...-

w-vv—M»

October 31, 1971
Dr. Jonathan 0. Cole
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are the
(1)
(2)
(3)
(4)

Also,

final drafts for the

Volavka

Theories

Fink
Fink and Abrams

Q

copies of Small and Small.

Note:

Abrams paper (clinical)
made on page 17.

Note:

Fink (theory) has page

I enjoyed the work. I

their standards.

&amp;

A

is included for the
S

of the citations missing.

hope the

editors find the material

Will follow tomorrow.
up to

volume:

Neurophysiology
Medical

Pitts

two

additions

ECT

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
83¢ o

,

�</text>
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                    <text>mm‘m—vm.

(’3’;

20 Sepfember l97l

Dear Jon,

Following our conversation,
The

I

Though? some more about

question of Joe Tecce. Enclosed ls

our recenf reviews of fhe penfofhal

diphasic response which
physical lines,

The

we

a

EEG

reprinf of

response. if shows

have lnferprefed along

In our

sfudy of amobarblfal and dexTroamphefamlne, assimilar curve was
in evidence, alfhough we chose To disregard fhe
and focus on fhe long farm

My

effects.

besf.

Wm."

l.

a

classical

operafion of a springnmechanism.

w

m.

one of

Sincerely,

iniflal changes

�</text>
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                    <text>"A

September 13, 1971
Dear Jon,
Two

One
One

it

Enclosed is the third paper for SeminaAA in Pbychiatny.
others are in final typing and should be out by the week~end.
is in fair shape and will have to go through another revision.
paper is still eluding me, and I will try again to extract

from

St. Louis.

._.».-,-

awn-rm

,Vnr'a",

I have asked three 'experts' to answer our questions.
set is in, the others should follow in a few days.
As

WM'W

.‘

'r

10 days,

return.

I wrote, unfortunately I will be in Europe for
but.should wrap it up within a few days on my

I heard that

you testified before Congress about the
you wish another 'expert' to appear,
be glad to do so. I had the opportunity to see him in action

Jaffe

bill. If

I'll

with representatives of industry regarding a development of
a long-acting antagonist, and was not particularly impressed.
v

r
-"

My

best regards.

U'VE'V‘

Sincerely yours,
"IV-\n,‘1-n'l,ﬂ'.?'ﬂ'

~17

0'

.arﬂ'vwwr‘v‘wa‘wﬂ

~mW§rw

mm:

Max

Fink, M.D.

One

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                    <text>E

Novamber 22, 1971

Dr.

J. 0.

Cole

Boston State Hospital
Boston, Massachusetts 02124
Dear Jon:
Should you wish to exoand yoor program to include EEG measures.
are pleased to couparato and analyze the tapes using our IBH 1800
systam. Our present recorder is a Hewlett Packard 3960 A (1 7/8, 3 31‘,
7 1/2 IPS, 6 track, 1/4 inch, PM) and your lab should have a compatible
recording system.

we

In addition, it is useful to have a sine wave oscillator
(similar to ﬁ.P. 2020c) and an oscilloscope monitor. We ”charga” users
according to the hours of computer time for EEG analysis and for such
statistical analyses as are required. For the usual studies you might
complete in a year, $4,000 should be very adequate.

Finally, should you need a new EEG, we have found the Grass
polygraph with 7P511 amplifiers stable and most satisfactory. For a
4-channel portable the coat is about $4,000; and an 8-chanaol about
$8,000.
We

would

to pleased to cooperate with your laboratory.
Sincerely yours,
Fink, M.D.
Protozoa: of Psychiatry

Max

MF:13

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                    <text>\‘

'3’

_

V

May

Jonathan 0. Cole,

a,

1972

M.D.

Superintendent

The Commonwealth of Massachusetts

Department of Mental Health
Boston State Hospital
Boston , R‘Iassachusetts 02124
Dear Jon:

I have asked Michael Taylor about the use of an antiandrogen in patients with abnormal sex drive. You may consider
cyproterone acetate (Schering, Ltd.) a compound introduced
—

by German

workers. The most recent report by Cooper gt_§l.,

appears in dnit. J. Pbychiat.,

on your

It

may

be worth the

next trip East.

120:

59, 1972.

effort to import

some from England

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

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                    <text>April 7,

1972

Dr. Jonathan 0. Cole

Bostan State Mospital
Beaten. ﬂasaachuaetts 02124

A

a»!

fkﬂmm

é‘

Dear Jon:

B'L‘u

I very much enjoyed the sessions in drug models of schiz~
&gt;ophrenia at the A.P.P.A. I was stimulatad to summarize some of
the discussion. and cialose a draft for your consideration for the

publication.
My

best regards.
Sincerely yours,
ﬂax Pink,

3.9.

Professor of Psychiatry

HF;ig
Enc.

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                    <text>August 28, 1972

Jouethan 0. Cole,

M.D.

Editor. Poychophermecologie
Boston State Hospital
591 Morton Street
Boston, Hesoechueetto 02124

Dear Jon;

I am pleased to submit the enclosed report, "A9~Tetrehydrocannebinol Effect. on Baum Bleetroencephelogru, Heart Rate, and
Hood" for your consideration for Raychophanmacolagia. In this study.
we have demonstrated an equivalence between the effects on physiologic
measures of smoked As—Tﬁc and marijuana, as well as dose related effects. The study e110 provides evidence of Eacobehaviorel relations
for this psychoactive compound.
Incidentally, I wont to thank you for recommending my eppoint~
went to the editorial advisory board of the journal — I trust I will
be able to support the quality of the reports in the journel.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

Hfzig
ﬁne.

�</text>
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                    <text>Docedbar 26th, 1972

Jonathan 0. Cole, M.D.,
Boston Statu Hoayital,
Boston, M333. 0212b.
Dear Jonathan,

yritz Ireyhana as editar of Comprehensive Psychiatry,
uhould be invitea to meetings at ceuncil of the APPA.
Unless thcre is some abjectiou, I believe he should be
inviteé t0 the next meeting. ﬁia present adareas 1!:
Fritz
2015

_

‘ID

Hy

A.
R

Frayhan, M.D.,

Btregt,

N.W.,

Washington. 9.0. 20009.

best regards.
ainaerely ycurs,

a...

.

MEX

p

MF/id

‘.‘.;7._,;.v..wﬂ.n_‘

—w;_

a?

7‘

=5,
.

11me

.

Fink.

”CD.

Prcfetsor of Psyuhiatry

"envy-x,

�</text>
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                    <text>'r
94.2.;

’

December 5, 1972

Jonathan 0. Cole,
Superintendent

M.D.

The Commonwealth of Massachusetts

Department of Mental Health
boston State Hospital

soston, massachusetts 02124
Dear Jon;

I read the ”Effects of Acute Administration of Papaverine
the EEG and Behavior of the Normal Geriatric” with interest.
findings are consistent with the prevailing hypotheses relating
change and behavior.

dCL on

The

LEG

The discussion focusaes on the issues that I would raise:
the selection of subjects and the drug dosage. The study should
be continued in elderly subjects with EEG evidence of decompensation.
Ihe dosage issue is also critical, and a dose finding study would
be useful, using progressively higher doses in pairs of subjects
until EEG evidence of change is clearly evident or behavioral tox—

icity limits further trials. (Now that our EEG profiling methods,
the recording and analyses, are standardized, the dose finding has
become the most difficult part of our studies).
text leaves a

battery of
significant time Span. When are
the behavioral tests done, in relation to the EEG, and in relation

tests is

The

few

questions unanswered.

large and must occupy a

to the drug ingestion?

How

long an

EEG

sample

The

is taken?

The hypothesis anticipates a change in mean alpha frequency,
abundance
(amount). It is possible for the amount of 8~9 cps
not
be
reduced, and 10-11 cps to increase, and yet, the total alpha
to

not exhibit much change. Indeed, this is not infrequent ~ we have
reported this type of change with cannabis, and others have noted
similar effects in cats with psychotropic drugs. It may be appro«
priate to undertake a ”narrow band” analysis, i;g., reanalyze the
records filtering first so that activity below 5 cps and above 13
(15) ops is suppressed, and then measure the changes in l—cycle band
widths from 6 to 13 cps:

�'T

December 5, 1972

Jonathan 0. Cole, M.D.

were unaffected, it is conchanges minimal. The task remains, to define
the central effects of papaverine, and both dosage, time, and sub—
jects may have to be varied to achieve the result, or to state that

Finally, since behavioral tasks

sistent to find the
CNS

EEG

effects are not significant.

George Gardos has sent us a restatement of the times and
dosages of the subjects in the thiothixene study, requesting a reanalysis. We will rerun the analyses as soon as I am able the
equipment is moving this week and it may be some time until we are
—

able to get to this work.

I look forward to seeing you in San Juan.
Sincerely yours,
Max

Fink, M.D.

Professor of Psydhiatry
iF:gg

�</text>
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                    <text>W

~

NWmn-Wﬂamzwanww

nun-m:

,Miamvmw—ww*w.ww

g».

mmmu—wumvme

~; a

'-&gt;’1!‘A.*

“1 :www- yam—cw,- t‘um

...

nay”;-

Wn -Wg-qmmw,~,

TBSB»0214ME

Jonathan 0. Cole,
Chairmen,

CHE

anusry 13.

M.D.

1973

Resesrch Committee

ﬁetionsl Institute of Mental Health

Roehville, Maryland 20852

Re:Mﬁ

28323-01

Site Visit, 1/12/73

Beer Dr. Cole,
In response to the questions regarding the use of EEG
measures as predictors end criteris for change in the proposed
study, Activated EEG and DPH Response of'thale Delinquents, I
pertieipsted in the site visit on January 12. Prior to the visit,
we had the Opinion of Dr. Joyce Snell to sugplement our questions.

1. The qusntitstive EEG methods for the evslustion or
the slphs~chlorslose response are not yet available; nor ere they
likely to be svsilsble In the forseeshle future, thus slloving the
sdditionsl funds in the second year (pg h) to be deleted.
2. The technique was described, end the evelustion of the
records by members of the clinical steff st the University of Maryland
will provide, using simple deseriptise eriteris. ressonshle estimstes
of the ehsnges induced by the drug. While the test is to be repested.
neither the investigators nor the superintendent know whether the
patients will cooperste. In response to the question of testretest reliebility. Dr. Monroe indiested that these dots are not
“-

available.

('r.-&lt;A

..
mw

r—

w»..—

guy

”wow.

vwwr

m»wm~1W.*"w~»W-‘x

wwrr

.

.v’twcmm’XTKFI’W-

While the test may have some merit, Dr. Monroe did
not make clear whet was the basis {hr the choice of this test, lesving
us with the‘distinet impression that the inclusion.vss in the
nature of s 'fish—ing' expedition.

is much eonfusion seong the psrtieipsnts as to
DPH,
of
the rslstion to blood levels, and the symytoms thst
the dosage
(sad
the
ere
the evslustioo eriteris) of this therspy. In
targets
oontrsst to the specific nature of the EEO test and its evelustion.
the psychistrio—psyehophsrmscologie aspects of the study seeeei so
poorly aoeueentsd. that the recommendation of the site visit teem,
srrived st unsninously, was Dsfbrral, with advice. The advice is
to include some pilot work to define drug dossge, acceptance of
3. There

criteris and ratings; and also, stteepts to test and
repeat testing in s smell group of suhégctgethaetermine if the
'
pstients' cooperation can he assured:

blood sampling,

‘

-mmwa-m~.n,

wvnrrr

Azumww

Sincerely yours,
Me: Fink, M.D.

7—,

'vr".sv

u" :

�</text>
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                    <text>rm”,

;

TBI~609

April 9th. 1973
Hr. Arnold Cantor,
P.O. Box 325.
Paranoia. 3.1. 10571.
Dear Arnold,

Enclosed is a copy of the inventory of equipmant
of tho Intarnationol Associaoion. an of April 1, 1973.
Ital: 1000-1003 are at tho atria. of the Ansocintion,
39 Arleigh Road; itana 100h~1133 are at the State Uhivnrsity
of How York at Stony Brook; and items llhhullTﬁ are at
the new York Mkdical College (5 East 102nd 8%.). The
items at the state University of Row York include tho
oomyutor installation and most of the technioal oquipmont.

rgo_‘!.$

—.'

Nagy...“

,Wl"!f‘}¢‘

:
”(new

while most of the itous can ho considered ”sol:innured". it would be prudent to obtain covorago against

tire,

wator damage and vandalism for the
1022-1059).

(um

IBM

1800

syttcn

I am also tnolouing abounonta from the New York
Mbdical Collogo describing the transfer of the oqnipmnnt

to tho Association; the relevant chapter: of tho HEW
grant. ndninistrution manual (chapter 1-h10); the grant
award for MR 2&amp;020 which includes $16,500 for renovation
of space far this oqnipnont: and an dbatrnot from

Newsletter (volumo 10, nudbor 2) dated February,
19?3. which nonworo tout quoations regarding the transfer
of equipment. These documents have been revievod by Hr.
Joshua Vogel. our legal noviaor, and it was hidgopinion
that legal title has boon transferred to tho Anabeiation.
and that V! should do all things which would be prudent
for tho maintenance and protection of the oqnipmont.
NIH DEG

Thank you

for your assistance.
sincerely yours.
Max

Fink, H.D.

Encouiive Director

MP/id

co.

Mr. Joanna vogel

Enos.

�</text>
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                    <text>August 22, 1977
Dear Jon,

letter of August 9
BCT who
interest. If you have such a

with regard to depressed patients
responded to drug therapy seduced
sample, I would agree that the
data should be published. However, one should be sure that the ECT
was given under conditions that meet present standards for ECT therapy.
Were the number of treatments adequate ? What assurance was given that
missed seizures were re—treated ? Was the diagnosis confirmed by an
outside observer or adequate history ? I can recall no recent report
of such an outcome (since the reverse sequence, drugs followed by
Your

who
my

ECT,

failed to respond to

is the

most common).

The second

question is difficult to answer. There is no

to show that ECT makes neurotics worse. The
predictor studies (Mendels, Carney, Hobson) all show that the more
psychotic the patient is, the better the clinical result; the obverse
can be inferred, the more neurotic (higher anxiety, less delusion),
the poorer the clinical result. There is also the problem that many
patients labelled 'neurotic' are labelled so because of an unclear
clinical picture, and they may develop into 'schizophrenic' patients
at a later date. This group also suggests that the less psychotic
or the less like a standard psychotic picture the patient presents,
the poorer the clinical results. As for specific citations, the most
detailed, citing his own work is Kalinowsky writing in Kalinowsky
good study of neurotics

,.,.

“use”

WNW?“

w—,r;.e..,,;,‘_,.,.,.

v

'1

.

’IH“~P"'-V‘

1.

and Hippius , 1972, pp 242-2u4), Pilowsky (Aust NZ J Psych. 288:88-9”),
Prendergast (Med J. Aust. 2:598—600, 1968) and Carney and Sheffield
(Br. J. Psychiat. 125: 91—9”, 197a). These are good for starters,
although I prefer the inferences from the predictor studies. You
may want to start with our own review of predictors (Brit. J. Psychiat.

l22:#57~u62, 1973).

report has been submitted to the Council of
I think it is quite good, and its recommendations are reasonable.
You will enjoy reading a capy. hhich you may be able to get from Mandel
or Fred Frankel (unofficially).
the

APA.

The APA Task Force

My

regards.

Sincerely yours,
Max

Fink,

H.D.

�</text>
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                    <text>July 13, 1992

Jonathan 0. Cole, MD.
Director, McLean Affective Disorders Program
McLean Hospital
115 Mill Street
Belmont MA 02178-9106
Dear Jon,
We seem to have gotten the same bug pharmaco-EEG -- at the same
time and we seem not to be able to get over it. I, too, believe that pharmacoEEG methods have not had the applications to which they lend themselves,
especially as the initial evaluation of potential new psychoactive compounds, nor
in the management of treatment courses, especially of therapy resistant patients.
The IPEG sessions in Boca Raton in May were a good sample of our present
experience. Unfortunately, except for some work in pharmacokinetics of
benzodiazepines by Greenblatt, and of opioids and anesthetics by
anesthesiologists, little has been added to our theoretic or functional knowledge
since the spate of NIMH/PSC supported studies between 1959 and 1975. These
studies developed the main algorithms for data reduction which are still in use
today. The main difference between 1990’s and the 1970’s is in the speed of data
reduction, ability to record and analyze multi-lead inputs (compared to our single
and 2-channel analyses), and the sharp reduction in costs; so much so that
practically any academic laboratory can do superior (to 19705) recording, data
reduction, and data analyses for under $15,000 for 4 to 8 channels.
-—

Unfortunately, the theoretic underpinnings remain the same as at that
time. And, many of the applications which we recognized as useful and feasible,
[and which are even more feasible today], have never had adequate trials.
Further, the present loyalty to the neuroscience reductionist belief structure
[which so dominates the ACNP, SBP, NIMH, and many academic psychiatric
departments] rejects any human recording studies as too gross. The main
exception are the polysomnographers with their activity in medical physiology and
the idiosyncratic, essentially impractical, sleep EEG studies of Kupfer.
A few years ago I summarized my experience with pharmaco-EEG in a
which
was not published. From time to time I have gone back to it, and I
report
enclose an incomplete draft, dated October 1991. On another occasion, I was
asked to review some reports by Herrmann which he submitted to the journal
Pharmacopsychiatry. I wrote an editorial that accompanied the papers. Finally, I
enclose a historical review which was published in 1984 which provides a basis for
our present knowledge.

�J.

0.

Cole

Pharmaco-EEG

Page 2

At the IPEG meeting in May, the applications of QEEG for
pharmacokinetics was well demonstrated. Its use in pharmacodynamic studies in
man was suggested, but there are few new studies such as Peter Irwin and I did
two decades ago. The industrial laboratories are apparently funding quantitative
pharmaco-EEG studies in various species. The pharmacologists are enthusiastic
that they can identify our present list of human psychoactive drugs, but they have
few examples of new compounds that have an identifiable pharmaco-EEG profile
in an animal species which helped in the clinical study of the compound. [I am
not impressed that this expenditure has much merit; rats, mice, dogs, and cats are
quite distinct in their pharmacology from man (indeed, mice have been bred to
be remarkably sensitive and insensitive to a host of CNS active compounds) and
it is pure happenstance when a compound has an EEG effect in an animal that is
predictive of its EEG pattern or sensitivity or clinical activity in man]
As for multi-lead recordings (such as the BEAM), these have not been
more helpful than single lead recordings in man. Herrmann and Coppola
undertook detailed analyses of multi-lead recordings of compounds which had
been classified by classical single channel recordings. Their findings were no
more useful than what was already known, at much greater expense. There are
some authors who argue that localized EEG changes should occur and they hope
that such differences will have predictive merit. But, so far, the data are very

weak.

With that introduction, I will answer your questions as best as I can.
1.

The enclosed papers are a good beginning. Get the issue of Phannacopsychiatry

24 (Nov):196-225, 1991. The three reports by Herrmann show what can be done

with pharmaco-EEG studies.

2. The best citations for the relation between EEG changes and clinical response

are cited in my report in progress.

3. Few studies fund pharmaco—EEG studies. I was recently contacted by Tetsushi
Inada, Ph.D. (Kyowa Hakko Kogyo Co. Ltd., 599 Lexington Avenue, Suite 2780,

New York City 10022). They have an antihistaminic compound and are seeking
ways to define its central activity. They were impressed by our 1979 report of the
EEG study of terfenadine and diphenhydramine (Phamtakopsych. NeuroPsychophannakologie 12:35—44). I sent them to Kurt Itil and have not had a
follow-up.
4. I am always willing to visit McLean. It might be useful to arrange a Grand

Rounds on pharmaco-EEG. I recently gave a talk for the neurologists: PharmacoEEG: Science or Pseudo-Science. Dr. Vasile should visit Itil in Tarrytown and get
an idea of which directions he is taking this technique. Turan and Kurt are quite
hospitable and seem willing to show off their techniques.

�</text>
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                    <text>my 13,

Dr.

Julian a.

1958

calm

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Lloyd Brothers

t$5727

Cincimeﬂ 29,

Bear I».

Ohio

001m:

Rind enough to refer
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Thelebomwrieeotthe Insttetemmwbeing
Wham. and
I resent that we m white. at the93am: time.
estebuehed.
Dr. Khmer

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,

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                    <text>am}

August 2, 1978

”gr-per

g
‘

“17;“?

mum”"

,vw,m%m-'

Dr. A. Collins
Department of Psychiatry

Lenox Hill Hospital
York City

New

Dear Dr.

,.
“rte.

who

is

an

Collins,
I am writing this letter on behalf of Dr. Arthur ZAKS,
applicant for admitting privileges at Lenox Hill Hospital.
I

have known Arthur since his days as a resident
in
New York Medical College in 1968. He
was an outstanding
student, a willing and enthusiastic workern and keen observer. He
began his research studies as a resident and thena continued
until the
end of 1972 to lead one of the research teams
in my Division of

psychiatry at the

Biological Psychiatry. He was a major contributor to our studies of
opiate dependence and has contributed much to our understanding of
the usefulness of methadone maintenance, levomethadyl,
challenges,
the interaction of bpioids and narcotic antagonists and heroin
the
specific
properties of naloxone. He was active in the study of naloxone pamoate,
one of a group of long acting opioid antagonists.

is an outstanding clinician and researcher. He is well
his patients and by the staff. My enthusiasm
for his work
was such that when I accepted a position
at
this
university,
I recommended
that he be promoted to take over the responsibility for the narcotic
research program, then running on grants and contracts at a level
of
more than $500,000 a year. I regretted his decision
to
leave
with
me and to enter private practice, but
since then I have continued to
share in his studies and interests.
liked

by

with as

He

I

much

recommend him

skill

and

highly and can think of few other trainees

responsibility as he has demonstrated.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>x
law

a»

40"me

:nnsvznr

w—r

~,

Inna-w-

wy...

‘I'“(“'.

w“.- ._,..,.,,W.,~r.

vlvu/anH.

-.,

‘nﬂV‘Lvr‘r'vvv ”H... a.

,

,

.

.

.,,

.,_.,,.,....~a.

n.—

.mmw—l-w n»,

_.

3;.

:‘x-i

'1'.“er

{mtgyr‘rw'v r.7v..lr'-"t:\1vw. w.

April

ll,

v'uﬁrh‘avv‘n""!v~n'v~m:

nay-aw

,-

.

-

«

,

.

1977

Dr. Francis C. Colpaert

Jannsen Pharmaceutica

Beerse, Belgium

B-23H0

Dear Dr. Colpaert,

It has been a number of years since I was directly
involved in studies of narcotics and narcotic antagonists, so that
your questions came as somewhat of a surprise. Nevertheless, I
shall try to answer as best as I can.
subjects repeated doses of heroin
that we did not observe
tolerance. When we gave oral doses of methadone, tolerance developed
rapidly, and when we gave such subjects injections of heroin, we
were able to observe cross—tolerance. Depending on time after
oral dose of methadone and dine, subjects either could or could
not distinguish placebo from heroin. They generally used as
cues their subjective feelings of relaxation ("high") plus the
change in skin tingling, respiratory slowing and occasionally
the relief of irritability. When we gave patients levomethadyl,
they developed tolerance as they ddd to methadone, and the same
pattern of cross tolerance to heroin, with a different time course.
When patients who are tolerant are given a single dose of naloxone
or cyclazocine, a severe withdrawal syndrome is precipitated. These
are the types of experiments we carried out, and based on these
observations I would think the answers to your questions are as
When we

gave

intravenously, the timing

was so spaced

follows.

1. The discimination of a narcotic from a placebo

is dependent on dose of the narcotic, state of the subject (tolerant
or 'clean’), and time in the withdrawal period that the narcotic
is given. If repeated administration is rapid (doses within a few
hours of each other, as in three or four times a day) then tolerance
is seen easily.
2. Users discriminate

active

from

inactibe material

their central effects mainly: relaxation, euphoria, drowsiness,
decreased irritability; and to a lesser extent from peripheral cues.
from

also use the relief of withdrawal symptoms
allowed to devlop.

They

if

these have been

m

-

t.»

H" -w-

w;

.—

mn. v.

~

_..--

�q;

(an.

-

-Wm—_~&lt;

-

Dr.

colpaert 0000000000000mch11’1977 000.000.000.000 page2

to tolerance.

3. The euphoric

I

trust these

effects of opiates are subject

comments

are helpful.

Some

years

ago, 1970 or 1988, I visited Beerse seeking some undeveloped narcotic
antagonists as werwere then hoping to find an improvement on

cyclazocine. I remember with pleasure the cooperation of the
laboratory personnel, and I am pleased that your work has continued.

My work at the New York Medical College continues
under the leadership of the chairman of the Department, Professor
Alfred M. Freedman. Should you wish some additional information

regarding their recent experience with heroin, naltrexone, etc.
you may wish to write to him.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>-r-'(~

...

m,¢:m"pr

w,

.1'

(1,1;

mﬂku;

F—uwv

June 16, 1969
Columbia University Praas
York City

Raw

Gantlanon:
Ha wnuld like to rocive a copy of the W80 Technical Report
#381, Neurophysiological and Behavioral Research in Psychiatxy. If

that: in a chargn,

we

wil; remit promptly.

Thank you.

Sincerely yours,

Max

Fink, 3.0.

Professor of Psychiatry

at]

�</text>
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                    <text>March 27, 1967

Dr. w. P. Colvin
Medical Departmnt
Burroughs Welloome and Co. , Inc.
1 Soarsdale Road
New York 10707

'Iuckahce,

Dear Dr. Colvin:

It was a pleasure to visit your laboratories last 'I’lmrsday
to revive the nemries of my earlier studies of Kemadrin. I
trust the afternoon was as helpful to you as it was interesting
to me. In the event that it is decided to investigate Kenadrin
as an antidepressant, I would be pleased to discuss such a study.
and

As I mentioned, we are embarking on a long-acting depot
phenothiazine study, assessing the clinical efficacy of
fluphenazine deoanoate in the treatment of schizophrenia. For
this study, we would appreciate meoughs—Welloone making supplies
of Kenadrin available for the study patients. It is anticipated
(see enclosed protocol) that the patients will receive injections
once every 7-21 days with the majority receiving injection at
weekly intervals. They will be enowraged to keep a supply of
Kenadrin at hand at all times and to take 1-4 tablets daily, as
may be required. For this purpose, we believe that Kemadrin in
wall containers usually supplied physicians as samples of
"Ehpirin Oanpomd" may be most helpful.
.

to provide tablets of Kenadrin (5 mg)
led it be possible
20
for a total supply of 5,000 tablets?

in sample lots of
Many

(“2214)

thanks.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mfzkp

�</text>
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                    <text>December 29, l967
Dr. M. P. Colvin
Medical Department
Burroughs Hellcome and Co., Inc.
l Scarsdale Road
Tuckahoe, New York 10707
Dear Dr. Colvin:

are continuing our study programs with long acting
fluphenazine and have found Kemadrin to be a useful agent.
Would it be possible for you to provide us with an additional
supply of Kemadrin, 5 mg tablets. either in a bulk of 5,000
tablets or in individual canisters of 20 tablets each, as
you previously supplied?
we

My

new.

Aw"

.&lt;

New

Year!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
A.

”w.”

best wishes for the

Mszp

�</text>
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                    <text>Pebmary 23, 1987
Dr. w. P. Colvin
Medical Department
Burroughs Wellcane and Co. , Inc.
1 Scarsdele Road
Tmzkahoe, New York 10707

Dear Dr. Colvin:

interested in your consents regarding the
antidepressant effects of procyclidine. At the time that
I undertook systematic studies of imipramine and chlorprunazine
at Hillside Hospital, we did treat a small number of patients
with procyclidine alone, in order to determine the effects on

I

was most

psychological

tests,

EEG

and behavior.

We

did not have

sufficient material for a detemination of changes in psychological
A copy of that preliminary
tasks, but the EEG data was
report is enclosed for your interest.

I look forward
convenience.

mind.

to discussing this with

you

at your

Sincerely yours ,
MEX

PM,

MID.

Professor of Psychiatry

Mszp

�</text>
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                    <text>April 8. 1968
ﬁr.

H. P. Colvin
Burroughs uellcome
l Scarsdale Rd.

Tuckahoe.

New

&amp;
'

Co., Inc.

York l0707

Dear Dr. Colvin:
We are continuing our study program of long
acting
flupnenazine enanthate (Squibb). Our experiences with the
initial 80 subjects has encouraged us to continue as the
treatment is acceptable to patients and appears to be as
effective as oral phenothiazines.

Approximately half our patients are taking antiparkinson medication and while we have recently obtained
supplies from the hospital. I would be grateful if you could
make available to us another shipment of 25000 tablets,
Kemadrin. 5 mg.

._

,

Thank you very much

far your cooperation.
[Sincerely yours,
Fink. M.B.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>December 18th , 1972

Mrs. P.

T0:-

Max

FROM:

summer:

Commerce

Fink, mu.

Recruitment

0: Ensure}: Assistant

.. 1800 Programmer

pm

of an: program 'Antagonists to Ogiatas' we
EEG records from the patients at the
collecting
anticipate
VJ». Kospital beginning mid January. In preparation for the
analyses of these records, I should like ta find. a
Research Assistant, 3.800 Framer who fulfills the
requirements , particularly the experience requirements. at this
position.
As

X would be
grateful for any ansistmee you can give
in recruiting candidates, because tha program will begin

opcrution about. January 15th.

ac. to Mrs. 0. (Winner
ids/13

Em.

‘

t

k":r‘~«"-

4'“

Tik’prﬁlu‘I‘lt’iﬁ‘H‘74T-ﬁw"Le/"*1

Dr. Leroy Brown
Dr. Steven Vaiabroth

me

�</text>
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                    <text>May

25, 1965

Secretary of Health, Education and Welfare
Conieeimer. Road and Drug Administration

Washingtm, D. c. 2020::

Attention:

_

‘

Dr. Francis 0. Kelsey

Dumbo. Kelsey:
For the past two years. the research laboratories of this
Departmnt have etuded the effects of a variety of psycmto—
mimetie agents in the severe mentally 111. Recently, when we
requested an additioml supply of Smyl (CL-395) from the
Parke maria Cowany, we were told that supplies could no lmger
be made available witlwm submieeim of an DID to the FDA, At
of Clinical
our request, 132:. P. S. R. Became of the Department
IND—1077.
Investigation submitted a letter oomeming their

'meyindicetedtMtifwemdeubuitanIﬂDmdobteinthe
studies.
_

they will ship Semyl to us for our
Comnittee of the Depaz‘mmt of Psychiatry
The
of Paydaietty of the mummy of
Hieeowi
Institute
the
at
School of Medioim has approved the emlosed pmtoool
for study. It mquims the administration of Semyl in our

approval of the

FDA.

Wlogicel

mm

populations.

:5thth

Hint are the ”131311st procedures to obtain approval of
this studybyﬂml‘oodmdbmgkhniniemﬁm,
Davis Cm)! will make supplies of Semyl available to us for

this pmjeot?

‘

.

'Wymverymdxforyamaseiatanoe.
Simmly yours,
ﬂax Fink, H.

D.

Professor of PsycMatry

HF: kp
‘

enclosure

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                    <text>August 5, 1990
Credentials Committee
Medical Staff Affairs Office

Box 0208, M-181
San Francisco, CA 94143

Gentlemen:
I am writing this letter regarding privileging in electroconvulsive
therapy, at the request and on behalf of Professor REESE T. JONES, Professor
of Psychiatry at the Langley Porter Psychiatric Institute and the University of
California at San Francisco. I have known Reese since the late 19605 when we
were both interested in research into cannabis. His electrophysiologic studies
paralleled my own, and we met frequently at national and international meetings,
and national committees of NIMH and NIDA, to talk about our work. Reese is a
sophisticated and experienced clinician, clinical pharmacologist, electrophysiologist, and researcher.
My interest in ECT goes back to 1952. NIMH supported studies of
ECT at Hillside Hospital and the New York Medical College led to numerous
publications in ECT; organizing a conference and publishing a book on the
Psychobiology of Convulsive Therapy (1974); a text Convulsive Therapy: Theory
and Practice (1979); and chief editorship of the quarterly journal CONVULSIVE
THERAPY since 1985. I was a member of the 1975-1978 APA Task Force on
ECT, edited many of the chapters of the 1978 report; and again, a member of the
latest APA Task Force which just published The Practice of ECT:
Recommendations for Treatment, Training and Privileging (1990). Since 1988, we
at Stony Brook have developed a ’hand-on’ training course in ECT for
practitioners, one of only two in the nation.

For the past five years, I have been director of the ECT Service at
Stony Brook, with full responsibility for privileging the professional staff in ECT.
(Fritz Henn, M.D., Ph.D., the Department chairman, is among those privileged in
ECT during the past few years.)
Sometime in 1989 Reese called to ask if he could come to Stony Brook
for training in ECT, as he was asked to re-establish a program in ECT at the
Langley Porter Institute. I agreed. In December, 1989 we met at the ACNP
meetings, reviewed his knowledge and experience, and based on that information
I laid out a 3-day program at Stony Brook which would meet the new guidelines
of the APA Task Force report. He invited me to San Francisco to meet the staff,
visit the facilities, and lecture on ECT. I did so on April 3-4, 1990. I was
impressed with the staff interest in ECT, met with the residents and made ward
rounds, finding three patients for whom ECT was clearly a legitimate option in
treatment. One was presented in a staff conference.

�Reese joined me at Stony Brook for three full days of teaching, on May

2, 3, and 4. I arranged for patients to be treated each of those days. His schedule
included ’hands-on’ treatment of 12 patients, some with unilateral and some with

bilateral placement; monitoring of seizure duration by cuff, heart rate, and EEG;
monitoring of ECG, blood oxygen, blood pressure, and heart rate; and the
determination of the degree of motor paralysis using a muscle stimulator. We also
demonstrated the seizure enhancing properties of caffeine; inductions with and
without glycopyrollate; anesthesia with methohexital and etomidate; modification
of blood pressure using trimethaphan; and blocking of a prolonged seizure using
diazepam. We discussed, for each case, the basis for the selection of energy,
electrode placement, frequency of treatment, and number of treatments. For our
out-patients, we reviewed the process of continuation and maintenance
treatments, using drugs and/or ECT. We also discussed the role and merits of
concomitant psychoactive drug use.
In addition, Reese made rounds each morning, interviewing each
patient on my service (about 15). We discussed the indications for ECT, how we
develop a risk/benefit analysis for each case to determine the suitability of ECT.
We reviewed the pre-treatment work-up including laboratory tests and the aims
of consultations with medicine, anesthesiology, and dentistry.
In the afternoons, Reese was in didactic sessions with my associates
and myself. He worked with our ECT nurse, Mrs. Irene Carasiti, and participated
in the discussions and videotape session which makes up our informed consent
process.I gave him a pre-print copy of the 1990 APA Task Force report; we
discussed the changes from the 1978 report; reviewed the main items of patient
selection, determination of risks and tactics to minimize risk; and the thorny
problems of training and privileging.
In didactic sessions, we reviewed issues of consent, mechanisms of
action of ECT, electrophysiology and cardiovascular physiology, and anesthetic
considerations.
At the time Reese left, we were both exhausted. I was delighted with
his knowledge and understanding. We had covered and met all the guidelines of
the new APA recommendations.
I am pleased to recommend Reese Jones for privileges in ECT; with
endorsement for routine treatments as well as the treatment of high-risk,
medically ill patients.
Sincerelyn yours,

Max Fink, MD.
Professor of Psychiatry
Attending Psychiatrist,
University Hospital

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

4/,

5

I)cpurnncntofPsychhnryinuchhavknalSdencc
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phonc25164®hL2447

.

.

April 27,

1977

Committee on Awards, Grants in Aid of Research
Sigma Xi National Headquarters
345 Whitney Avenue

New

Haven, Connecticut, 065ll

Gentlemen:

like to endorse the application of Mr. Jay Schneider
of the effects of ACTH 4—10 on the EEG and DC
recording characteristics in monkeys. I have known Mr. Schneider for
half a year, as he has been associated with Dr. John Stamm and Mr.
Oliver Gillespie in their studies of ACTH H-lO.
Mr. Schneider will graduate from the State University of New
York at Stony Brook in June, and is matriculated as a graduate student
in psychology at this University for September, 1977. During the past
year he has been an active collaborator in the studies of ACTH #10 and
he proposes to continue these studies next year.
His interest in the problem has been stimulated by Mr. Gillespie,
his
by
rand
readings. I have been a consultant to the project and in the
late fall, I invited Dr. Henk van Riezen of Oss, Holland to visit the
project at the University. The meeting was fruitful fOr it clarified the
direction of the research and the present work is an outgrowth of that
I should

for support of

.

session.

a study

'

studies of the effects of peptides on memory and brain
functions are derived from the work of David de Wied of the University
of Utrecht. I have been doing some of the human assays in my laboratory
and stimulated the present efforts by Stamm and his colleagues. The
significance of the work is well defined: the effects of ACTH 4—10 seem
to prevent the extinction of a learned response. It provides an interesting
opportunity for clinical studies in patients with memory deficits due to
aging and as a result of electroconvulsive therapy. We are pursuing both
leads clinically. The work proposed here should provide a neurophysiologic
underpinning for the clinical studies.
Mr. Schneider is working in a well equipped laboratory under
experienced and competent direction. The funds requested will permit the
present efforts to continue; to expand the measurements of changes
induced in the EEG and in DC recordings from brain areas not studied
well before, the prefrontal and infratemporal cortex. In the rapidly
expanding field of peptide studies, I think that these exercises at this
University will be most.helpful in understanding the effects of these
substances on brain functions.
The

Sincerely yours,

7L.»

Max

J’W

Fink,

M.D.

Professor of Psychiatry

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                    <text>Mr" .

June 16, 1969
Committee on Brain Sciences

National Research Council
Washington, D.C.

Gontlenen:

Facilities

would appreciate a copy of the 1380 Survey of Research
and Manpower in Brain Sciences, as doacribad in a recent issue

we

0; the Mental Health Digest.
Thank you.

Sinceroly yours,
”may—'wW'i

Max
-73;

ka, rm).

Professor of Psychiatry

KC

m

(

‘.

X
a

\

r

a

in}?

G

a

l

.h
-.

Ti

,\\

�</text>
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                    <text>7383—777AP

16 Novambcr 1973

Alberto DiMaocio, Ph.D.
Boston State Hospital
591 Horton Bttcot

Boston, Massachusetts 02125

Dear A1:

After I rcccived your

letter of

Octobor 2k indicating that

"wt cannot extend your invitation to Dr. Honk Van Riorcn.” I
called Jon Cole and than Dick Wittonborn to discuss tho content
of your letter. You must be aware that I became concerned about
two ocpctcte issues: first, whether the Secretary of the ACE?
or the Council of the ACNP have the privilege of rejecting an
icvitction by a Fellow and, second, the manna: in which you

notified no.
As

to the accond point, I understand you called my officc,
it was to discuss this mattcr with no. I trust

and perhaps

wuwutMrmwm

I havc road the Bylaws of the Association as well as the

memorandum of August 8. 1973. Nowhorc in the Bylaws nor in tho
August 8 monorcndum does
state the guidelinco to be used by

it

the Secretariat in rejecting invitations by Fellows. I believe
that your lettcr-cvon on bchclf of Council~~may he an arrosa~
tion of authority which may ho unjustificd. I say "may be" beccucc in youtcrday'u mail I roccivcd a memorandum from Dr. Wit—
tcnborn which may explain the attitude of Council but does not
justify the action of the sucrctcry. I need not remind you
that tho ACE? is fellowship of non intorcatcd in a common goal,
and tho invitation of a goon: usually rcflccta serious consider»
ction and should be givcn unusual «tight by the Fellow: and cc~

:

by tho sccrctcry. who. sitar all, acts to curve the
Fellowship. I undarstand that thorc will bc an opportunity to
discuss the question of inwitod guests at tho forthcoming coating.
and I intcnd to participate in that discussion.

pccially

Sincerely yours,
Fink. M.D.
Professor of Paychictry

Max

MF/cis

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m...

7385~78888

28 Havonbar 1973

H E H O R A E

16

:

n

U M

ﬂarriat Chriltuan. nouearch Administration
Pink. H.D., Profonsot of Psychiatry

from:

Max

Subjact:

intuit for

Permian Truval

W;

w

.W-v-m-wrr

mug—m

m-vwmmv-v‘lm'

”5”,...—

mu".

mmﬁv-ﬁ

WW5:-

—'ij'

ivy-'7.

-:

v-vv-v

wwwv

Jami-”F7”

l

Encloaaﬁ in copy a! the capy of thc Intent sent an
October 15 and approved by Earhart whiningnr an behalf of
the Gradusta School.
Mrlcis

ﬁnal.

�</text>
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                    <text>April 10,

1965

Intamatioml Congas: for

Neurology and EEG
Winner Kodiziniad‘w Akadmio

Alscr Stub.

M

Wian IX

mm

Gentlemen:
.41

Enalomd is the registration foe on behalf of

Dr. ﬂax Pink for the Sixth International 6mm”
for £86. I have already filed the mgiatmtim form.

Sincerely yams,
Max

Pink.

M. D.

Professar of Paya'datry

Mfzkp

�</text>
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                    <text>731~Tlh

Juno 19th. 197 3

Chad

th

Bunk,
22 Green Aroma,
(but Hock, 3.2.

Gentleman,

Pluto «noel

out on bum:
amount of $2.500.

made

cheek 01211

and April
14.13;

of Coat“ Btofmiu,

10, 1973.

in the

sincerely you".
Fink. 15.2).
m
Executive Director
149/13

�</text>
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                    <text>Septesber 12, 1966

Continental Aseoclatlon of Funeral
and Haaorlal societies
59 last van Duran
Chloago. Illinois
Gent lawn a
A

street

recent edltorlal in the

new En

land Journal of

Medicine brought the work of your society to Iy
atESnEIon. I would be grateful for a 11st of the

associate societies in the new York area. The editorial
also mentioned a Manual of agggle Burial publlshed by
arollna. I: such
the Celo Press in urnsv e. no
I would appreciate
sale.
for
available
or
dlstrlhutlon
is
a copy.

Many

thanks.
Sincerely yours.

rink. “.0.
“3
Professor at Psychiatry

�</text>
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                    <text>September 18, 1970
Control Data Corporation
575 Lexington Ave.

New

York, ﬂew York

Attention:
Dear

Mr. Pagano

Sir:

RE:

Customer #4596

Effective this date please cancel our rental agreement

on the 0217

digiscribe display.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

cc: Hr. Tozzi
Mr. Tozzi:
CDO

requires

satisfactory.

us out of

it,

us

to notify

them and

this letter should

be

contract has a 90 day clause. If you can get
they can take the scope immediately.
The

ELF.

�</text>
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                    <text>December 8, 1969
Dr. Donald P. Conwell
Assistant Commissioner

Department of Health
Chronic Disease Services
125 Worth

New

York,

Street

New

York 10013

Dear Dr. Conwell:

to your letter suggesting meetings of
addiction research, perhaps you are unaware
in
representatives
that Dr. Dole holds such meetings at monthly intervals.
You may write to him at Rockefeller University or to
Dr. Doris Clouet at the New York State Research Institute
for Nurochomistry and Drug Addiction, Ward's Island,
With regard

New

York 10035.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

�</text>
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                    <text>u". r on"- ..,___.v"

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'mv

December 8, 1969

wwuztv'

“w

WWW—1,...

'r.

r

mm—IiLMsMV-Kv'

Dr. Donald P. Conwoll
Assistant Commissioner

Department of Health
Chronic Disease Services
125 Worth

New

York,

Street

New

York 10013

Dear Dr. Conwell:
,mvwrr

.

,

gm.»

".7

r

-"u.:

Avrlw'ﬂl'r'

w

wag-nu

to your letter suggesting meetings of
representatives in addiction research, perhaps you are unaware
that Dr. Dole holds such meetings at monthly intervals.
You may write to him at Rockefeller University or to
Dr. Doris Clouet at the New York State ﬂesoarch Institute
for Nanrochemistry and Drug Addiction, Ward's Island,
With regard

New York

10035.

Sincerely yours,
:‘iax

Fink ’

3.1%.

D

0

Professor of Psychiatry

Mszp

- w

w

&lt;

-

�</text>
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                    <text>April 1,

1969

Dr. Ellsworth Cook

ASPET

Bethesda. Maryland
Dear Dr. Cook,

I have read your announcumant at a wbrkahop on Principles
of Drug Evaluation in Man, scheduled for Jun: I~13. I have been
interested in the problem for many years, and have focussed on the
use of electrophyniologta tachniquea in studio: of new drugs in man.
If at :11 practicable, I vauld lika to participata in this workshop;
and am writing to raquest ppplication forms and ptogram.
Thank you.

Sincerely yours,

ﬂax Fink, K.D.

Profasaor of Paychiatry
mf/

�</text>
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                    <text>ﬂaeenhar 13, 1962

Mr.

Gilbert 8.

Emu,

Managing

Editor

Aréhivea af General ruyehiatry
535 Narth Danrhorn Street
Chicago 10, Illinnis

ANA

Dear Hr. Casper:
The nmxt

isaua nf thy Aréhivea of Gennral Fwychiatry

includaa an articlc writtin by Dr. Dunald F. Klein and myself
entitled "Behaviaral Rnnctian Pttterna with Phenothiazinex".

I will be grateful if yau can water an eras» for 109
additinnal reprints with anvers far my paraanal use. If this
can ha done. glanse sand 1 regular raqunat farm and the churgaa,
and I will pay diruetly.
Thank yum very muéh.

Singerely yours,
HISSGURI IHSTITHTE 0P PSYEHIATRY

Max
‘I

16!: w

Fiﬁk,

Diruetur

H. D.

Airmail

Platte «adreas correnpandenea to: sane Aracnnl street. 8t. Lnuia 39,

Mo.

1
1

�</text>
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                    <text>September 9, 1975
Mrs. Judith A. Cooper
19 White Cliff Lane

Neseonset,

New York

11767

Dear Mrs. Cooper,

misunderstanding. At the
time that Mr. Irwin interviewed you we had not yet clarified,
whether the position would be part— or full—time. That has since
been clarified, and the position that is available is full-time
at-the Long Island Research Institute.

I regret that there has been

some

we have advertised in Newsday this past Weekend and we are
in the process or awaiting replies, which will be reviewed by
a committee, and those candidates who seem to meet our criteria
will be interviewed.

now

Should you'wish to be considered for a full~time position,
I should be happy to have your credentials reviewed, among the
others, at the committee's meeting next week.
I hope that the facts are a sufficient explanation for any

misunderstanding which

may have

occurred.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF/mr

�</text>
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                    <text>Homer u,
Dr. R. Cooper
Burden Neurological

Bristol, England

196:;

Institute

Dear Dr. Cooper:

It was

a pleasure meeting you in Santa Fe. As I
left with Grey Walter, we had the opportunity to discuss your studies with implanted electrode and multi—
focal frontal leukctomy in psychiatric patients.
You may

recollect that during the meeting

Dr.

Brazier's paper was read and she reported finding spike
activity in certain depth electrodes when surface elec—
trodes dmmstrated a desynchronization of rhythms. Her
surface frequency Spectra clearly demonstrated patterns
midi were remarkably similar to the results of the
intravenous or oral adnu'nistration of imipramine.
In your work, have you had the opportunity to
administer imipranﬁne to one of your subjects with depth
electrodes in locations similar to those described by
Dr. Brazier, and if so, are the observations in the

public

domain?

I would be grateful for copies of your reprint
in this area especially that of the Journal of Neurology,

Neurosurgery and Psychiatry of 1961.
Thank you very mch

for your cooperation.
Sincerely yours ,
Max

mf ; ls

Fink,

Director

M.D.

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                    <text>January 27,

1971

Dr. William Cooper

Sterling Winthrop Research Labs.
Rensselaer.

New

York

Dear Dr. Cooper:
We have been requested each year to submit summaries
on each of the new patients inducted on cyclazocine during

the year.
corrected

A

for each is enclosed as well as a
of the patients currently on cyclazocine.

summary

list

Thank you

for your cooperation.
Sincerely yours,

u

11'

an"

Fink. M.D.
Professor of Psychiatry

Max

”Ft-'mwwwjb-HW

MF:kt

enc.
:rn

,

�</text>
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                    <text>w

won-yumwm

."tq'c'o

January 1A, 1971
Dr. William Cooper
Winthrop Research
chssalaer, New York

Sterling

Institute

Dear Dr. Cooper:

are interested in continuing our studies of cyclazocine.
present we have 52 patients on continuous treatment and are
inducting new ones at a rate of 1~3 each week.
We

At

we have recently had some crises about the supply of medication
and I am writing to request a continuation of our present arrangement,
$42;9 a monthly shipment about the first day of each month with an

increase to

300

bottles, addressed to:

Dr. Arthur Zaks
Department of Psychiatry,

Metropolitan Hospital

Room 15A9

1901 First Avenue
York, New York 10028

New

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc:

A. Zak:

�</text>
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                    <text>"Iraq“

.zn-m—xr—ur-w-w

"-7.;

1-

w

w

.w

.

&lt;Q‘,"F“.“I,

July 30, 1971

&lt;

rv‘""'wv‘."'nw“':I,-‘II

Dr. William Cooper

Sterling Winthrop Research Institute

Rensselser,

New

York

Dear Dr. Cooper,

Enclosed are additional case records from our
cyclazocine study program for your files. The top pages
the names of the patients entering and discontinuing the
study since our last report.
Thank you

list

for your cooperation.

Incidentally, I have received indirect reports that
quite successful in investing cyclezocine in a longacting formulation. If true, it would be a useful sdjuvent

you are

to treatment .

Sincerely yours,

th Fink,
mf/

M.D.

�</text>
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                    <text>mung-n

uwr-rl/v'v

a...

n

-—.w'

&lt;

m».

:vnw-

m...

v:—

June 2, 1959

ﬂW:-Ww\m‘

-

Dr. A.

(5. Copper)

Clinical Investigation

Ward

of

Medical Resend} Council
West Park Hospital
Epsom, Smey, England

mm,
Dear Alex,

It was

a pleasure to participate in the GIMP program
I believe the final program to be a.

committee with you and
well balanced one.

discussed, I an enclosing, some reprints of our BCI‘
in 19 57 - the neuroxﬂiysiologim
available biochenzical—psydmlogic
data as well as the interest in psychologie neurohumrs. The
recent observations that drugs altering brain function can
directly alter psychologic mallards-ms lend more weight to the
first part of the theory and less to the second.
As we

studies.

The hypothesis proposed
adaptive - tried to encompass the

In 1959—60 I was impressed-Mitzi; the date of the olnljnergic
neclwxism and especially by the results of my studies with anticholﬁnergic drugs. Perhaps the same results could leave been
achieved with sympathondxretics (indeed, LSD did antagonize Em‘
produced EEG slowing) but I did not study them carefully.
men no

new

reassess the

301‘

date appeared

by 1965 I submitted the draft for
enclosed. Perimps it is time to
process with as web entimsiasm es sleep, lithium

publicatim, and a

copy

is

therapy and mnomnines have received.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry

Max

�</text>
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                    <text>April 22, 1963

Dr. Norman L. Camah
Department of Psychology

Washington University

Lindall

8

Skinkar

‘

St. Louis 30, Missouri
Dear Noam:

It is

a pleasure for us to participate in the university
shall aontinue to make the patient material
available to your students. As you may know, Dr. Sol Garfield
will be'joining both our staff and Br. Bunch's in anne, and
prognmms, and

I

that ha may facilitate our cooperation.
While I would 11kg to join yuu on tha 27th, I will be
of
town. I hope the damonatration is satisfaeﬁony.
out
hope

Sincerely yours,
Max

HP:aw

Fink,

Directar

H. D.

�</text>
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                    <text>5pm,

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