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September

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Dr. Fred A. Clark,

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A. H. Robins Co.
l407 Cummings Drive

Richmond, Virginia
Dear Fred,

as,

,

have read the
andimin (fenfluraminei,
I

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questions:

summary portion of the submission on
l6—6l8 (vol. 4.l) with the following

NDA

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is the presentation clear and does

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claims of the

the

the 'labelling' section present the data clearly and
concisely, sufficient the convince the examiner that the claims
for a new drug as 'safe' and 'effectlve' can be substantiated;
Are there additbonal studies that should be considered 7
impression is that the summary is written poorly; that
redundancy, leaving an impression of 'padding'; and
some important issues regarding anorexigenlcs are omitted (persistence of effects, tolerance, dependence, and similarity or
dissimilarity to dextroamphetamlne clinically). The summary is
complete and sufficient in demonstrating that extensive pharmacologlc,
metabolic, toxicologic, and clinical studies were done. Indeed, the
amount of data and number of studies are impressive. Yet, i can
easily imagine the text Inducing doubts. Some criticisms to be found

there is

in the

My

much

details are:
the

same

tables

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it substantiate

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data is presented in a variety of ways;

do not present the

salient issues clearly;

sections appear as testimonials, diminishing the

merit of the data base; and,

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some language is obtuse, leading the examiner to focus
rather than ideas.

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-2There are two types of data that seem to be treated less
adequately than one could wish. One issue in the use of the
anorexlgenlcs is the extent to which they inhibit appetite, reduce
food intake (or increase metabolism) to yield a gradual loss in
weight, and to do so safely. The criticism of dextroamphetamine
is the short time it is effective (7tolerance), its abuse
potential (?dependence), and the occasional toxicity expressed
as insomnia, irritability and tremor. (The same can be said about
other stimulating anorexigenics.) i find the comparison of
fenfluramine and dextroamphetamine incomplete. The tables on
pp. 28—33 are impressive but they lack clinical data. Perhaps
the two drugs should be contrasted as to stimulation, secondary
effects, abuse potential (has this been demonstrated or tested 7),
and dependence. Such a comparison could emphasize the unique
properties of fenfluramlne, make the labelling claims distinctive,
and allow for approval as separate from the anxiety occasioned by
dextroamphetamlne abuse.

issue is duration of effect. A principal
criticism of dextroamphetamine is a limited period of efficacy.
These data doeaot allow for a decision as to whether continued
use of fenfluramlne is associated with tolerance, or whether
weight loss is sustained. Are increasing doses necessary to
sustain weight loss 7
The second

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clear,

With regard to the labelling
and useful as far as it goes.

cited above, although these answers
labelling.

section, find
It is deficient
i

may

not

be

it

adequate,

in the issues

necessary for

opportunity to discuss the conclusions of the
committee meeting on anorexigenlcs with Elmer Garner and
Donald F. Klein. Both indicated that the agreement in the committee
i

FDA

had an

limited; that no anorexlgenic was really 'proven'; and none
sustained wieght loss. l enquired about the questions of tolerance
and dependence, and these seemed the principal anxiety in
approving new compounds. "Do we really need another drug to be
abused ?" l suggested fenfluramine may be significantly different
than dextroamphetamine, and Dr. Gardner seemed attentive and
interested. He said the FDA was about to allow an NBA for
another anorexigenic, and he expressed the opinion that there was
little reason to hold up an approval for fenfluramine.

was

My

separately.

specific

comments are attached. The volume

is returned

leaving for Europe and will return October 7. l have
dictated and typed these notes rather hastily, knowing you wished
a reply as eoon as practical. My thanks for the opportunity to read
these data, and i trust the submission will not fail. if i can
be of help at the FDA, l have no hesitation to meet with them.
i

am

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

,

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                    <text>October 19, 1958
Dr. Fred Clark, H.D.

A. E. Robins Co.

Richmond, Virginia

Dear Dr. Clark,

Enclosed is a draft copy of a suggested protocol for
the evaluation of AHR~1906. This protoool has been approved
by my staff and has been submitted to the appropriate committees
for approval. I as also enclosing a completed PD 1572, and
supplementary oopies of the rating scales and laboratory data
form to be used.

study should result in a olintcsl report,
analyses of the behavioral changes by the Biometric Laboratory
of NIMH, analyses of the laboratory data by Binders, Inc., and
a summary of the EEG patrorna.
The completed

while
before the
within the next
supplies or for
could arrange a
Earth. I would
study of a long
come

there are some administrative hurdles to be over—
study can be undertaken, I believe it can begin
6 weeks. Before submitting a request for drug
grant support. it would be most helpful if you
visit to these laboratories on one of your trips
also like she opportunity to discuss your suggested
acting fenflursmins.

you have had the opportunity to read this protocol,
would you be so kind as to call my office ? Many thanks.
When

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Mex

nil

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                    <text>September 3, 1968
Dr. ?radar1ck Clark, M.D.

ACE.

Rabm.

Richmond, Va.

‘30.

Dear Dr. Clark,
Thank you for tha informational material to: A£R~1900 and thn
enquiry regarding an EEG study of a dalayeé aetiou funﬂlurcmine.
I hava found both queantons of grape intarest and cansiderahle
challenga. and would lit: the opportunity to discuss this with
my associate:. Unfortunatsly, two are still away on holidays
and will not return for another week, and I will be away for
aama dsyn

thereafter.

I am writing to ask yaur indulgnnce 13 my daisy
in annuaring these enquiries. I will writs or nail yan ﬁuring
the third waek a! Septanbar.
Sincerely yours,

Fink, M.D.
Prefeanor of Psyahiatry

Max

'm/

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                    <text>June 24. 1969
Dr. Fred Clark

A. H. Robins Company
1407 Cummings Drive
Richmond 20. Virginia

Dear Dr. Clark:

In our studies of AHR-l900

we need additional supplies.
please ship us 500 capsules, 200 mg the an equal
number of placebos. Sample labels are attached.

Would you

Many

thanks.
Sincerely yours ,
Fink. M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>April
Fred Clark, M. D.
Robins Cb.
1407 Cummings Drive

I], 1972

A. H.

ﬁichmondL

Virginia

Be; Labelling

of

Butaperasine (Repoise)

Dear Fred,

I am pleased to answer the inquiry regarding the labelling
of.Repoise (butaperasine), limiting its application to patients with
chronic mental disorders.

I have

studied butaperasine since

1964,

assessing the

clinical effects in chronic schizophrenic patients; the EEC and clinical
relations; the effects of'concentrate (syrup) Repcise in acute mentally
and in association with Dre. Itil and Holden at the Missouri
ill;
Institute of‘Psychiatry, have been acquainted with their data on the
effects on clinical laboratory tests and the EKG.
In these studies, and in reading the published data, we
to be an effective antipsychotic agent with a
low profile of'extrapyramidal effects. Dosages can be increased rapidly
and the therapeutic effect can often be observed in 3 to 4 days. In its
EEC profile, putaperasine exhibits a characteristic hypersynchrony of
alpha activity, enhanced amplitudes, decreased variability of'frequencies,
and in higher dosages, enhanced theta and delta activity with a reduction
in fast frequencies. This profile is similar to piperasine phenothiaaines,
such as fluphenasine.
have found butaperasine

In the clinical studies, its activity is similar to fluphenasine,
in acute and chronic cases. From this point of’view, the implied
limitation to chronic cases appears arbitrary:
fhe difficulties in differential diagnosis is great, and
is
it often impossible to decide whether the patient is acutely ill,
a relapse in a chronic illness, or an acute exacerbation in the
course cf'a chronic illness.
both

Zhe symptomatic

is not specific
these
the limitation is

response to phenothiasines

for schizophrenia, but is related to the

symptom complex. we view

acting in a non-specific fashion, and
thus arbitrary. For example, patients with anxiety often show a reduction
in this symptom, regardless whether the symptom is part of'schisophrenia

compounds as

�_

.~

.w

.

,_.

,

.

r

-7.

”y,

“.2“, .,. 7...,

... .-

.w “my...“

, .'.- .1,

v

m._ N wwrv

T,

w....,....,., 1.....vww-sw. »—.=- a...“

w

3.,

--

n

.-

.._. ,. ..- .

.7

PW -,

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. .

.

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gnaw

v&lt;,."'l).‘5a .

W'WW"

~,—

NW.

.

or a part of an anxiety syndrome; similarly, the sypptom of psychomotor
agitation often responds whether in schizophrenia, depressive psychosis,
or senile agitation.
In

my

experience the decision to use a therapeutic agent
on a clinical diagnosis, but on a symptom profile,

is usually based not

it

and some elements of history. From this point of view,
seems arbitrary
and an unnecessary implied limitation on the decisions of the physician
to continue the labelling restriction for Repoise for chronic cases.
From another point of view, the limitation restricts the
teaching of the use of Repoise. In teaching residents the principles
of psychopharmacology, it is a special burden for the teacher to attempt
to describe the use of butaperazine and note its limitations. It is
much easier to recomend the use of fluphenazine, for which no such
limitation is implied (and incidentally, for which a variety of form-

ulations exist).

I trust

these

comments

are useful.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

Ref:

Therapeutic Studies in THerapy Resistant Schizophrenic Patients.
Cbﬂg. Psychiat. Z;488-493, 1966.

Clinical Laboratory Test Standards in New Drug Trials.
1—8, 1967.
J. Clin. Pharm. &amp; New Drugs,
_7_:

Organic Treatment

of Schizophrenia. In:

A.Freedmand&amp; H. Xaplan (Eds.), Williams
pp. 661-664, 1967.

Textbook
&amp;

of Psychiatry,

Wilkins, Baltimore,

Treatment of Chronic Psychotic Patients with Combined Medications.
Neuropsychopharmacology, Excerpta Medica, Amsterdam, 101601020,1967.

Differentiation of Psychotropic
9:267-—280, 1968.

Drugs by

EEG

Analysis, Aggressoloﬂe

Liquid Butaperasine (Repoise) in the Treatment
Mental Health Clinic. Curr. THerap. Research

of Psychosis in a

_1__1_:

57~63, 1969.

.&lt;~.'—VI'.A.\

�</text>
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                    <text>'1

1w—

~1W‘Wﬂwxw—WVMW'.‘MKWUKV' v.-

u.-»w...—-~.,-

.

ware-m

.

-

“wt.“-

-. l':n—,W.r.-'.-"w

-—uv",_

W
um
WW
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We
W1
W1
Nam. 0km

‘4'.-V-&lt;.\v-4.”.

mum-r ‘1“.

“no

.

”WWVIV-

8, 1965

Dr. H. L. Clark

State

Darth.

Hospital

Clark:

Imjmtmmmmmsmmm
W10”

mating for the Maxim Comm of Clinical

mamﬂmtyouhmmlmdmevalmimof

mnmxidol.

Habawjustmpletadasizﬁlarmmdlm

Mingﬂzenbertyofaendingywaww. Ifyammport

isavaihblo.1ww1dbap1medmmiwampymdm

wwwacimiminwmmmabem
Wren-mum.

MWmmtumtgummmm
mmwwﬂxQMmemW

mm.

Hymn-gum.

Simiy was,
Max

Fink. “.33.

Manor of marina;

&gt;rv—74‘v’

ﬁnd-w

«yr-mm‘w

.VW w'qrv-'r— u» n-wrv‘

�</text>
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                    <text>ﬁeptcmber 20, 1969
M. Clark
School of Public Health

Mrs. Korean
CU

New

York City

Bast ﬁrs. Clark,
Thank you for your invitation to participate in the
caurue in Public Eealth on October 22. I ragret that I am unable to
participate, as i plan to attend a conieranca in Califarnia during

that

week.

May

I auggeat that either of

staff may be both able and willing to
suggest you write to them directly.
Dr. Arthur

M.

Dr. Richard Resnick, H.D.,

Thank you

at

my

other

participate,

23kg, M.D.,

Both may be reached

two

members

of

and I would

Instructor in Psychiatry
Assistant Profenaor
address.

agtin.
Sine-rely yours,
Mu: Fink, M.D.

Professor of Psychiatry

mf/

my

�</text>
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:v-r 'v-q—vr

"W“vw"

”"mem

m

September 13, 197h

Siva Sankor, Ph.D.

Queens Children’s Hospital

7&amp;903 Commonwealth Boulevard
Bellerose, New York llh26

Dear Dr. Sankar:

I regret the delay in answering your letter of

but it was sent to
yesterday.

my

former University and

August 20,

I only received

it

I thank you for the invitation to contribute to the volume
on "Psychopharmacology in Childhood”. I regret, however, that I have
little original data that I would consider for submission in such a
volume. However, my former associate, Jovan Simeon, of the Missouri

Institute of Psychiatry, has had extensive experience in this field.
I would suggest that you write to him should you wish another
participant in your volume.
My

best regards.
Sincerely yours,
V

Fink, M. D.
Protessor of Psychiatry

Max

MF:ed

4

.

�</text>
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                    <text>”a

a

I

-

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- r- WWI"

&lt;

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mus-aw,

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w

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November

«.e-u—W—WWWW...‘—mw-

1h, 1975

William G. Clark, Ph.D. Chief
Veterans Administration Hospital
Psychopharmacology Research Laboratory
Sepulveda, California 91318
Dear

Bill,

‘nwwwm-IVLAW

The
-

Lecture courses are given in psychopharmacology.to the medical students.
15 1-hour lectures which are given by muself and my

course consists of

co—workers.

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A similar lecture course is given to psychiatric'residents. In each of
three
their
years their exposure varies, so that first—year residents have weekly
seminars and lectures; second~year students have about ten hours; and third—year
students have lectures about special topics such as childhood payehopharmacology,

geriatrics psychopharmacology,

and drugs of abuse.

Psychiatric residents get an extensive experience in clinical psycho—
pharmscology since the leader of our residencyyttaining program is one of my
students who is convinced that hospitalized patients are benefitiddnnst+bvyblbe
logical ﬁlnﬁﬂment, and least by verbal.
Residents may elect to work for six months or longer ql‘an elective in
which
evaluate new drugs the efficacy and safety. ’Two~residents'are in
the units
such
now.
experience

It is

-

.

how to answer your question concerning lab work. The
monitor
their drug treatment by blood studies done at
residents are required to
least weekly,m at least monthly, anE EEG. neuropsychologiosl; and memory tests

not clear

at periodic intervals.

I

V

.

,

in

am glad that you hams a shapter on EEG and drugs
man.1t was a
Beside
omission
can
think of no
in your e-arlier session.
myself,
significant
be presumpand
write
such
woulﬂ
than
a chapter,
one better Qualifiea
Itil to
me
of
tuous
to attempt to modify his text.

V.

_

‘

wags-'1'!

I

it

Sincerelnyonrs,

nynjwwwvm-

Profesaprlof'Pnychiatry

m

mm:

V

r -~-

-~-

�</text>
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                    <text>.».Vt{m".\'

mm:

mnwrr-

:wwn run-r www- I'vw-K w-vr

v

-

v-vvv—rv-mv u-"v-

.r.

-

.

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"‘~a.»wm;.w 4%; r

.r-

W
October 23, 1975

_

William 0. Clark, Ph.D., Editor in Chief
Principles of Psychopharmacology
Chief, Psychopharnacology Research Laboratory
Veterans Adnﬁniatretion Hospital
Sepulveda, California 91333
Bear 3111;
The following information describes the training program
available in this department. The training opportunity is in the
Laboratory for EEG and Human Psychopharnacology, and in the Division of
Therapeutics of tho Long Island Research Inetitute. I an the director
of the program and member: of the staff are lieted below.
we have generally worked with Fellow: who Join the Division
for e onenyear period, or longer. The work is principally a research
opportunity in electrophysiology as applied to paychopharmacology and
candidates are encouraged to undertake individual research projects,

which are funded by
’r"

overseas.

my

or.

this Laboratory.

Stipends are available, particularly for candidates from
’

.,,

is

application of quantitative EEG
to pharmacokinetic studies. classification of the montally ill,
The emphasis

«mm

.7
.A

'ra'l-mpvvl

-r-

.

on the

methods
and identification or new,peychoective substances. The work is focueeed
on normal volunteer: at the University and in patient populations at the
Long Island Research Institute. Both laboratory and clinical work are

included.

wmwuwm-mwrv

_.
u":

For physicians, a requirement is an ECFMG, or a license to
practice in the State of New York, if they wieh to participate in the

clinical program.

.g-rwvw

Wm-

The only language requirement
members of the staff

the studies; however,
and Spanish.

is that English is used in
are facile in German, Italian,

�Willi“

Go

ﬁnk,

Ph.D.

10/23/75

“’2"

in...”

...,.

l-

.

H.

A.

U...”

..,.,-..

‘Jn‘n’-

do not give e degrse for this work, but candidetca who
hers completed two yeere of resiasney training cen obtain credit for one
year toward their Board requirements through this program.
we

3-,

The

present

numbers or

the teaching staff are:

”I“,
m
Professor of Psychiatry
MI Ds

Whiter

G.

Bennits.

M.

D.

Visiting Research Professor (University of
Alexander

Genoa)

M. Don

Asaociete Professor of Psychiatry
Bernardo Heller. M. D.
8r. Reaesreh Scientist
Long Island Research Institute
Michael A. armor; M. D.
Aeeociate Professor of Psychiatry
Richard Abrams,

M.

D.

Associate Professor of Psychiatry
Timothy

M,

24.1)...

Research Scientist
Long

no.
'

Island Retesrch Institute

I trust this intornstion is helpful.

volume!

Good

luck in your

Sincerely yours,
Fink, M. D.
Professor of Peychistry

Mex

MF/mr

think you might son a chapter on the electrophysiology of
in the revision? It was en omission in the first
drugs
paychosctive
edition which msde tho volune much loss useful {Or an in my teaching.
9.8.

—

Do

you

M.

�</text>
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                    <text>-—

October 9, 1968
wg/zwmm‘:~

:4

-.:.a

.7.-

Dr. John A. Clouson

Visiting Professor of Sociology

Department of Sociology
The University of North Carolina
Chapel Hill. North Carolina 275l4
'

Dear John,
The wasting of the APPA Council will be held at 6:30pm,
October 25, l968 at Sun Luck Imperial Restaurant (935 Lexington,
corner 69th and Lexington).
Ho

look forward to having you with us.

Sincerely yours.

mmrhu.nm.
Secretary

�</text>
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                    <text>July 20,

1969

vv-vv-vb-m"

wannmv.

Clearinghouse

Springfield,

Va.

c'
u:
1.4

.r-n

Gentlemen:

Kindly send us coping of the following reports:

"’5

"W?

”"9”?“

v‘r'xw‘v'ww

wrv'wml'm'

A

and ask

costs.

we

that

et

AD~683 734

Dubes,

AD~686 216

Borkhout

a1
&amp;

Walter

M?

0.65

M?

0.65

would also like to subscribe to Clearinghouse announcements
you sand on a list of the categorioa ana their respective

Thank you.

Sincerely yours,

Max

Fink,

M.D.

Profeooor of Psychiatry

5 East 102 Street
ﬂew York City 10029

�</text>
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click
32—15

Long

Book Binding Company

37th Avenue

Island City,

New

York

Gentlemen:

three volmes of EEG Gun. :Jemphyséoin which
would like to have bound in nation with gold lettering.
Enclosed

we

an

Lettering should read:
£30

EEG JOURBSAL

V01.

1971

30

'

JOURNAL

Vol.

31

19 72

EEG JOURNAL

Vol.

32

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming, purchase order

will follow.
Sincaraly yours ,
ﬂax Fink. 24.3.

Proton-or of Psychiatry

iii : is
Enc.

�</text>
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Click Book Binding Company
32-15 37th Avenue
Long

Island City,

New

York

Gentlemen:
we

would

Enclosed are three volumes of EEG Cﬂin. MauKOphyA£0£., which
like to have bound in maroon with gold lettering.

Lettering should read:
EEG JOURNAL

Vol.

1971

30

EEG JOURNAL

EEG JOURNAL

Vol.

Vol.

31

32

1972

1972

Division of Biological Division of Biological Division of Biological
Psychiatry
Psychiatry
Psychiatry
A

confirming purchase order

will follow.
Sincerely yours,

Max

Fink,

M.D.

Professor of Psychiatry
Ming
Enc.

�</text>
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                    <text>June 17 ,

Joyce G. Small,

M.

1971:

D.

Lorne D. Carter memorial Hospital
1315 Vest 10th Street
Indianapolis. Indiana h6207
Deer Joyce:
My associates, Peter Irwin and Steven Knhn, ret
with the information we requested. There may be enough for
analyses and we will lohk at them in the next few weeks.

Q14¢/

you for your information on DH—Szh. we
have begun our dose-finding and it is encouraging to know them the

I

want

to thank

clinical effects.
When I was seeking a PI 6208 in the New York area, 1"
celled California and was told that the machine was no longer made
nor eveilahle. I left my name, however, and received a cell on
June 1h from Jim Jordan, beon Electronics, (71h) 556-6500, saying
that he has located a PI 6208. If you are still looking for one,
or if you wish to reserve one in the event funds become available,
you may wish to give him a cell.
compound has

It

was fun

my

best regards.

from Oregon.

being with you, Iver, and our hypomenic

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                    <text>November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�</text>
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                    <text>Septombor 29, 1969
Dear Doris,

that tho word "EEG" be included in the
discussion
at the Biochemical Pharmacology
title of the forthcoming
re~rood
Discusoion Group, led no to
your lettot. If the focus is
to be on 'ourront thoropy programs involving the one of ogontoto
and antagonists', than the EEG in peripheral, for in our hands it
is a research index only. The new douse have been dofinod by other
means. and in our clinical testing, the EEG 13 tho indox upon‘whioh
we put some rolianoo, but other: havo not accepted our Viewo.
I will discuss the EEG data, and yet helluva you would profor a clinical
discussion. For this reason, I omitted EEG in the title. A compromise
may be:
Your roquoat

-

Drug Tﬂernpies

of Opiato Dopendonce:01in1col and
Assay Methods of Efficacy

EEG

In addition tO‘thO usual mailing list. would you send on
announcement to Dr. Joneph Bitd (Sterling~w1nthrop). Ralph Jaooboon
(Endo), Henry Brill and ﬁarold moioolos (HYSHACC); and another
half dozoo to me, so that I can send them to some others who may be

interested.
sooner.

Hy

I look forward to seeing

boot regards.

you

at the

meeting,

if

not

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/
Dr. Doris Clouet

Research Institute for Nouroohemiotry
Ward's Island
NYE

How

York City

.

�</text>
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                    <text>septembet 5, 1969
Dear Doria,
Thonk You for the invitation to speak to the New York
Biochamiool Pharmacology Diocuooion Group on Octobor 28 at the
How York Acodemy of actuaton. I on ploaood and honored to accept.
and will uoo as my text, tho summary of our work that I am preparing
for your volume.
.

'

If I understand the tonne of the letter. I am to cover tho
cliniool oxporionces with the various antagonists, including
cycloaooino. onloxone and uothoddno; with sown reference to the
aifforontoo 1n nourophyoiology of thoso compounds; and aoggooting
thereby that the node of action of oath may bo quite different.
To doocribo the neurophysiology would require sumo reforenco to the
EEG pattern: of each of tho oompoundo both along and with heroin, and
the pattern: of heroin olono.
‘OK 7

The title can‘bo ono of your choice; porhaps,
Pharmacological Therapios of Opiate Dependence: A Rational Therapy 7
or, Io Opioto Antagonism out a Rationnl Approach to Thorapy of Dependence?
‘

The

ready 800 .

chapters are in the process of rodrnftiog and should be

Again,

.

my

thanks for thinking of me.
ﬁinooroly yours,

Fink, E.D.
Profaasor of Psychiatry

Max

�</text>
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                    <text>November 21, 1969

Dr. Doris H. Clouet

Associate Research Scientist

State Research Institute
for Neurochemistry Drug Addiction
Ward's Island, New York 10035
New

York

&amp;

Dear Doris,

Enclosed are the two manuscripts requested for your
volume on ”Biochemical Pharmacology of Narcotic Analgesic
Drugs”.

I regret the delay, but considering our dual appearance
in your volume, I think we have done reasonably well.
My

best regards.
Sincerely yours,

ﬂax Fink, M.D.

Professor of Psychiatry

MF:kp

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                    <text>January 22,

1970

Dr. Doris H. Clouet

Associate Research Scientist
New

State Research Institute for
Neurochemistry and Drug Addiction

York

Ward's

Island,

New

York 10035

Dear Doris,

Enclosed are copies of the two reports which
submitting for publication in your volume.

we

are

The reference to Wikler 1965 should be deleted from
the electrophysiological report.
The quotation of Lewin was originally published in 1942
German.
In 1964 his work was translated and published by
Button and Co. and
is that edition from which the quotation
I
believe the quotation an appropriate frontispiece
is taken.
and would be pleased to have
heed the article. The way in
which the 1942—1964 discrepancy can be justified would be by
adding at the foot of the frontispiece: Lewin, 1942 (translated,

in

it

it

mm”,

'a'ww‘rn

1964).

Thank you

“Myrrh-Hr

my

for your kind statements about the articles

best regards.

w-wwarwxv

Sincerely yours,
“no"

,.

Max

Fink,

M.D.

Professor of Psychiatry

HF:kp

:‘vrnvw

A
&lt;

u

it?!“

and

�</text>
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                    <text>January “h,

1961+

Dr. Dem Clyda

Biomtric laboratory
Urdvemity of Him
250 Bird Road

Cm]. Gables

‘06

, Florida

Daar Dam:

Imus soaxoitadtomoeiveywroallyastarday

that!

neglected to ask yau what the diffmnoe of EEG patterns was.
Wen you milled. I was in the uddst of discussing what I had
named about canonical comlatim with Jim deer-plw. Man
I told Dr. '16.]. about the finding, he said that was obvim,
and indicated that the pattern mum be
beta-2, less alpha

m

mmdaltainﬁnschimphmnimwithmalphainﬂndepmaim. Is that so?

I an: aligned that you will be at the WP. You should
that our study
is planning a two-day dismaim of
EEG minis... We have invited Dan Walter
digital techniques inmp
of U.C.L.A. to present am of the momtical 13106313 new in use
atBRI. Inaddiﬁmtothemualmmnbem,2. Rodem,Jorm
Stemmdf’rwﬁcﬁzvinwillalsoboﬁwm. Itshouldbaamod
swim if yen have not opted for mother mp.

lmow

in early

I

look fmwam to seeing you next 'mumday. If you earn
perhaps we can an“: feather Wedmsday night.

my),

My

best regards.
Sincerely yours .
Max

Mf‘zmlg

Fink,

Dimmer

M.

D.

�</text>
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                    <text>Jammy 23,

19614

Dr. Dean Clyde
Biomtric Labo-mtmy

Lhivemiw of

Miami

250 Bird Road

Coml Gables

Q6

, Florida

Dear Dean:

first forty lines of the
is the write-wt of the
We
have
a nmriber of questions.
Dr.
text of the article by
dereau.
We will be able to redo the first line with the text nuzﬁaer
Enclosed

preceding, the word "evaluation".

‘

Humor 1
be deleted?

in line

I4

refers to mferenm

-

1

5.‘ Should

Qwetion umber two 13 the cemetien line 18.
correctly? The same emetic: with regard to line 26?

Is this

this
done

Hmlly,hmdowehandlethepmbhrh'ofsudwmemasm

colon and the apostrophe. I believe these should be

that comet?

Before we go any
'

and have

those

I

have

fmer,

I

would be

EEG

Wedetice.

availabla,1willmmmmtoyw.
'mmik you again

rmIHillside
have

soon as
'

.

Fiﬁ.

Director

Em.

As

Sincerely yours ,
Max

HFxmlg

report

for the write—out.
-

153

grateful for any

identified the patients in the

just wked for the age

mm.

M.

D.

_

�</text>
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                    <text>Fcbrunry 17, 1964

Dr. Dean Clyde

Btoaccrlc Laboratory
Univorlity of Miami
250 Bird Road
Caral Gable. #6, Florida
boar Data:
After leaving sunny Florida. I can: to the Midwnat winter
tad promptly went to b¢d. Aftat a nook, I an 3:111 coughing
and only regret that I atdn'c tannin in tho sun country.
no, and 1
gratatnl for the program: which you gave
hi?‘ acne ttho on to the ﬁntvatsity Canter. I had hoped to
be thin to work with than this wank but hnvn not had the
opportunity. I look forward ta doing so shortly.

I In

none

Again. uy thank: for your paticncn and consideration.

Sincerely yours.

at:

Fink, H.D.

Ditcctor
H?/jb

�</text>
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                    <text>February 20, 1966
Dr. Dean Clyde

Biometric Laboratory
University of Hioai

250 Bird Road
Coral Gables 46. glorida

Door Donn:

Jin Vanderplas is sitting bare with no,

end we are going over the
he has just completed on

roeolto of a canonical correlation which
the Hillside data.

rirot.

toot of the poyohologioal test date and tho EEG
example 7, and the values seem to be similar to
yours. We have some quentiono because the numbers are not idooticel.
For one thing. we how: 126 subjoots. For another, we may have used
e different 0?? for otoadincss value: than you did. Nevertheless,
the canonical correlation was 0.50 for a Chi Square 81.7. The second
correlation, 0.37 and the Chi'Square 45.6.
he too a

similar to your

he continued and ran a number of the questions that bothared on.
Specifically. tho ditfotence scores on behavioral oneeureo against
difference scores in the EEG monouroo. This was done for each drug
group and

for the total population.

'

Unfortunately for me, in neithor for tho total population nor for the
individual groups did we find a significant correlation. Béspairing
of the logic of using different scores and frustrated by ion: doubt.
about this program, I wonder if you would consider checking on us by
running I ttnoniool correletion for either tho total group or for any
of the groups using the following variables. In each instance tho N
was modified to reflect matting data so that only templete subjects
were used. This gave us for the individual treatments B's of 39, A7,
and 47. The problems that we used were: ll (2. A, 7, 10); 12 (l. 9.
10): 13 (1—6 incl.); 56 (1-6 inol.); 61(2~5 incl.) for the left side,
and 62 (l~5 incl.) for the right side.
Hy

best personal regerde.
sinceroly youre.

Hr/jb

Pink. 5.8.
Director

Max

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                    <text>March 7.'1964_

Dr. been Clyde
Biometric Laboratory

Univeteity of Kieni

250 Bird Boyd
Coral cities 66, Florida

Dear Dean:

for the canonical correlations. i turned
these over to Jim Vendetplee, end they do indeed disagree. He
checked the aquations in T, W. Anderson. and believee that
thoeo eqoetione ere eimiler to the once that hc in using. He
believee that the difference may be réleted to the-criteria
that are being-need in the two programs. He eeke, therefore,
if it is possible to have a printwout of the Fortran statements
of your program. Our progreomere will uncertake a line by line
cocparison and determine the places where discrepancies exist.
Thank you very much

In the pest cock I have had two opportunities to discues the
discriminate function analysis of the EEG difference: in the
two eobogroupe of och110phrenie and depression. we have else
checked some of the original records that Mex sent to me, and
the significant element is the slow wave activity which may be
related to the use of the edoleeoent group. If-the prepoeod
enelyeie of variance in e very complicated maneuver. might we
not achieve the same end by repeeting a discriminate analysis
deleting the nine eubjecte who are labeled “childhood achieo~
phreoie”? If then. the difference between the two groups still
exiete. even if the significence drops, could thie not answer
the queetion of the eejor effect of the adolescent group?
M3

bent regards.
Sincerely yours,
Me: Pink, M.D.

Director

”In:

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                    <text>March 25, 1964

Dr. Bean Clyde
Biometric Laboratory
UniVersity of.Micmi
250 Bird Road
Coral Gables 66, Florido
Door Deana

has had an opportunity to debug and updato his canonical
correlation program. I on taking the liberty of enclosing a
dock of cards which reprosonts the out: on the six psycho~

Van

logical test variables and five EEG variables, for
has determined residual change scores.

whioh he

first

eigenvalue is 0.134326. and the
We would be grutoful if
0.366505.
canonical correlation in
you oonld run this data in your ayatom as a final aback on
our program.

Using his program, the

One question that has arisen in whether the machine you use
may have diffaront charactotiatios thou tho 7072. Do what

anchino do you run

this data.

is it run in single, double
digits you arc
toll
and

or other ptaoiuion?
carrying intotnally for each Operation?
Can you

no how many

Thank you very much.

€1n¢¢rcly yours,

MIX F1133. MOD.

Director

Hfljb
ERGO

�</text>
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                    <text>“J} ,4},

x

April 9. 1964
Dr. Donn Clydo

Btountrtc Laboratory
Univornity of Miami

250 Bird Road
Coral Gablns 46, Florida
Door Dean:

for the canonical correlations on
the Hillsidc rastdosl secret. I hnvo sent tho data to
Jim Vondcrplos. A: a use: of computer: and computer
sorvtcon. I-an confuood by the discrepancies. Since 1
cinnot boltovo that it to in tho machtaery. I suspect
that. it an error in the program here.

Thank you very mnah

Thanks again, and if Jim has any
communicate with you.

other questions I will
Sincerely yours,
Fink, Mtn.
Director

Max

KF/jb

‘

a,

‘éﬂ

y;

3‘

A:

.I

‘

.
far. “36*

~
‘

ma,

5

31

.

"- 5‘7.

�</text>
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                    <text>April 17. 1964
Dr. Dean Clyde
Biometric Laboratory
University of Ninni
250 Bird Road
Corsl Gables ‘6, Florida
Dear Donn:

Since receiving tho discriminate function analysis for the schizophrenic
pstients using the EEG measures in January, I have spent
time
sous
to try to uoﬂststend tho apparsntly unusual results. Before

and depressed

receiving this analysis. it was my impression that schizophrenic patients
usually had lower voltage, fast frequency records in cospstison to depressed patients, The latter usually boing older. had slowmaiphe records as
the dominant psttetn.
You:

analysis

activity

and a

that our schizophrenics had a grsstsr degree of delta
significantly lesser degree of bats activity.

showed

Vs hsve txamined tho

papnlatioo characteristics of the

20

patients at each

and of the discriminate scale. First, of the 25 patients at the schisophrsnic and of the scale. 9 were labeled childhood schizophrenia and 8 now

differentiated schisophrenia. More important. tho moan age of the first
20 pstients is 22.9 years and of the last 20, 43.5 years.
vs hsvs roviewsd the rscords in this group of auhjacta. Two things are
most striking. In comparison to the records as now sue, the Hillside
records had a grant deal of alpha activity, wore exceptionslly wall modulated,
with high amplitudes. Neither in the schizophrenic group not in the deptas~
sad group on us have the commonly dastribed low voltsgo. fast itaquency
record. Secondly. the younger patients scan of whom aro labeled childhood
schizophrenia and some of whom vets labeled undiftorsntisted sohisophronia,
have no fast activity and tha only theta dominsnt and delta dominant rscotds
are in these subjects.
‘

Thus. tha fraouonoy analyser data is supported by our review using visoel
analysis. Tho roason for the difﬁarenoe in the two groups may not lie in
the diagnosis of sohisophrania es such. but in thu unique qualities of the
Hillside population. To confirm this suggestion, I rsviewod ths psychopatho~
logical chstaotaristioa of these 60 patients as described in the physicians'
referral rating seals. For theso patients. there were no diffsrences betwsen
the childhood schisophrsnie, the dspresoad, and the schizophrenic grouse in
sueh important symptoms as agitation, delusions, depression, hypoactivity.

or coofueion. The only distinguishing characteristicﬁwas in the incidence

�Dr. Been Clyde
4-17-64
Page Two

of hellucinetione uhieh appeared in h of the 9 childhood echieophtenice.
a of the 21 schizophrenics. and in none of the depressive patients. In
many weye, the Hilleiée Boepitel populetion heeleeeer degree: of psycho—
pathology than is commonly deecribed in the majo: acute treatment centers,
or in etete hospitals. A: such, the separation into two groups by diagnoeie
is poor.
The most important observation

is that those

young

petiente

who

are classi-

fied childhood schizophrenia or other young echieopbrenice may have on~
usual amount: of slow veve eetivity end lees then expected amounts of feet

activity in oontreet to all other schizophrenics and depressed petiente.
to Deve Engelberdt when we visited in Florida, and more teeently to the child

EEG

This finding should be examined end I have made such a recommendetion bohb

psychiatrist at the St. Louis State notpitel

and

et

Weanington University.

It is difficult

to get to the Hillside Hoepitel materiel in face of ell the
exciting things that ere being done here. Howevet. this hes been e
valuable
experience.
very

new and
Many

thank: for doing thin analysis for us.

that the neonate: people at Heehington 3., their
e few days ago to eey there was e program error
end they now obtain the identical numbers thet you
also for helping them out.

You ehould be pleeeed to know
feces somewhat red, called me

in their canonical
tent to them.

have

gyngrem
Thanks

Sincerely yours.
Fink.
Director

Hex

mm!»

K. D.

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                    <text>November u, 196k

Ir.

Dem Clyde

trio

laboratory.

mity of

250 Bi!!! Road,

Miami

Coral Gables. #5, Florida
Dear Dean:

16-!
Wearelookingtohavingyouvisitwithuson

Nmnber-H-acr.

In addition to visiting on

Novenbor

I
£3}:

withushem, Iwilltrytommgeavisitatthenew
medical omputing group at Washington University.
On Mday, I was reminded by my secretary that the
deadline for omtributions to the Eastern EEG Society
was about to pass and so I quickly wrote the enclosed abstruct. You may recall that last winter, following your

teaming session, you were kind enough to carry out the
on the Hillfunotim analysis by
side Hospital EEG data. Subsequent to that time, Dr. Itil
and I went over the EEG recorch thermolves and the re—
have taken the liberty
sultais the enclosed abstract.
and
eta—author,
hope that my interas listing you as a
to
pretatim of the data sheets is oorreot. I would like ab—
this
some
tine during your visit to go over
set aside
stract and our data. m one exanple of the kind of
nonipulatims to which frequency data lends itself.

diam

climb

I

My

best regards,
-

Sincerely yours,
Max

mf/ ls

Fink,

Director

M.D.

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                    <text>Kay 25, 1965

Ir.

Dean Clyde

Biantrio laboratory

humanity of

Miami

P. O. Box 8293
Cm). Gables #6,

Plaid:

Barnum:

Enlooodmafwﬂnaloopmofmmpwtmtod
cam

baton tho Society of Biological Psychiatry. and the

ofalnmrwhiohlhavejustmttomuokﬂallinmsponw

tomquirioswhiohlhnvemeivedﬁmhim.

Idomtlmow

hwtocvaluatehisdosimtomviowthoﬁillsi‘e data.

The

malymﬂmthmliahodwiﬁlyoumgood,arﬂlmnder
ﬁmowwtgﬁnmfmgvinghimthodntaandletting
mmaﬂaitinhisomoompulsiwmmﬂmbywﬂh—
holding it? While this is probably a decisim for w associates
atﬂillaidammwithm,lwouldbegmtefulform

mm.

'

Impeymgetﬂuadditimal

uipmntyoumqucs’cod,

facility. Aapart
mmtymosublishmmmlys
ofﬁnOollabomtivoSclﬁzqmrthmeotIhavodecided

tooo—opemtewithﬂynenbarinaml
tapesthatheis
going to collect for us in New York. I anticipate son problem

Wtiblo,
willbemfulforallofua.
inmldngtho tapes
My

best

but

I believe this experience

mm.

Sincerely you-a,
Fink, H. D.
Professor of Psychiatry

Max

Pﬁkp
enclosure

'

�</text>
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                    <text>5‘3”“:”(9‘5“ "

W
Dr. Dan

J.

8. 1983

Clydu

attenuate mammary
307
250 Bird Road

Room

Coal Gama, ﬂorid:

331%

Durban:

Immnntojoinyminymmmmdnyappm
Mdymboabhtoutuiduﬁmday,mlogfw
Wiﬁxinthomxtmdaya,1uﬂl

mtogommmmidadnta?
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IfﬂxisisWh.IhmaMmdnymmmmwt
tomudvmitylmmwiuuﬁwmowning,ms.

ably.

851ml)! yam.
Mu Fink, H. D.

Dinctw
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Em.

2

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                    <text>December 3, 1963

Dr. Dean Clyde

Bimtric Wow

Lhiversity of

250 Bird Road

Miami

Coral Gables “6, Florida

Bar

Dam:

I find that I am unable to lwe New York on Monday,
DacemboerhmdinatoadantakingﬂuTuesdaymmingﬂight
(Eastern

#605

arriving 12:39pm.)

May

I join you about

Sincerely yours,
Max
MFsaw

Pink,

Director

M.

D.

1:30?

�</text>
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                    <text>Muff-Ki»)

December 27.. 1963
Dr. Dom Clyde

Bicmou‘ic Laboratory
University of mm
250 Bird
Coral Gables '16, Florida

W

Door Deon:

First, let me tell you how ranch I enjoyed my visit and the course.
than, I havo gone over mob of tho Hillside data with a fresh View,
I am inclined now to mite another ropwt on tho EEG data. The compo
*

L

Simon

-

and

was

ospocially rewarding to

me

since

we had data.

low

to both of us to discuss.

it. Separately, I am sending you the tape with the full Hillsido
data. Attached is the mpblom timber index and a sample write-out page.
more om two listings on the tape- the first by patinnt; the oecond, bypmblom number. 111: mlo smote will indiootc the format. Code for
mining data in 9999.

thlemo Ill-.11} are the specially mated "drug—mitive" scoloo
mooted by the Hillside staff; 15 in not on those tapes no it was available
in 50 pntionto only; 30-32 an individual EEG band data
(3, 3.5, n.0, n.5, 5.0, 5.5. 6.0. 6.5, 7.0, 8.0)
(9, 10, ll. 12. 13.5, 15, 18.5. 18, 20, 22.5)
tho original data.
(25, 27.5, 30. as);

we

2. I havo examined the various write—onto of our studios using
discriminant ﬁmotion, and find none comparing ochizonhonieo vs. otMr
on
data. If we wish to add to the present question as. to
another schizophmnics do have EEG patterns different from other mortally
ill, w my approach the Hillside Hospital sample no a wall collected ample.
Pro-data for each of the fivo hando (Prob. 62, #1 ~ 5) and total sum
(Pmb.62 96); or the 2:. hxdividml bonds (Pmb 30-32) are tho EEG datn to be

Winn

to do this analysis?
We do have the covariance data for tho total grcup.tho
and tho others, comparing tho effects of placebo, ﬂmoino mud imi
compared.

Do

you wish

3mm

�Ir.

Dem Clyde

Page

the

Decanter 27, 1963

effects, reflected in the two Erotica and the toteste (see data page
copied, attached) are the seen for each diagnostic mop, with the possible
exception of Prob. 62 #5 (051 on the sheet dated 1/9/62) in which schizophrenics
show a marginal F—r-atio (reweion) which depressivee do not.

'Ihe

3. I looked at the covariance data of Prob. 62 91-5 to determine to
meat extent the pro-data contributed to the poet-difference. (i.e. , does pro-mm Y-oquare
data cmtrihut
ute to precision of difference scores”. Comparing”
to sun Moore of coeem, shows that the use of pro-data increases precision
markedly for each variable, for a factor of at least 2X and occaoimally as
ouch as ex.
14.
The comical correlation model for EEG and psychological tests
in the pro-position is batrig‘uing and I am enclosing a set of references which
show com similar relationships. The moot careful studies are
of
Heady—Castle. Warm, Ohriet, and the review by Ellingoon.

W

Over-riding the pattern in the Hillside data

is the factor of

age,

and any ftmther studies must “parcelaout' this factor. If adolescents are
included, they have higher memento of elm wave activity and lower performance
than adults. If aged are included (eee (wrist) than there is poorer performance
and higher slow wave activity. .If both are in the Sample (as with Hillside) then
this my be a factor in the result.
5. The omonical nodal is intriguing and as econ as Vanderplae
back from his vacatim, I will ask him to run a few trials at Washington

is

University.

If you wish to follow-up the psychological» EEG relatimehip,
amtl'nr analysis or the post date, or the D-oooree for the total grow
We! be dame. (Or. is it preferable to do each drug separately? I think not.)
5.

I

was moot

intrigued by your library approadr. I have diemzeoed

Mahler again and he responmo by again suggesting that
start with Peychophem. Ahotrecte and an SDI mdel. He had proposed this
last year, and P80 8 mm tmmed us dam for "momma" reasons. I
have called Jon and asked if we could not revive this proposal.

my

we

interest with

In the mammile, I am running a few ewerinente with deecrdptigo;
and carrying the
having references from various sources perched on
.

literatm

m;

retrieval“ promung.
In checking the IBM 7000mm: librery programs, we fomd name to
provideadictionary. 'Ihereieoneforwaotsmitteninmmnaeeomdinmchine.
. If your Form list and/or deck is available in Mateo form, I
would he mteful for a copy.
This letter is long enough. I will send it off, and will follow with
another copy of our new write-onto and :pephe for EEG analyaie. My best wishes
for a Happy New Year, and for many, my; more to cane.
on “information

»

Sincerely yours ,
Hex
Mrzaw

one.

Pink,

Director

M. D.

�</text>
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                    <text>January 28. 196“

J. 01%
mivemity of Miami.

Dr. man

Biamtxic Laboratory

Bird Road
Coral Gables as , Hedda
250

Dear Dun:

I had some difficulty in obtaining the age on «am of the
subjecta beam the original cards had been misplaced. We are
new available.- and I am enclosing the minnow: for 3am subject.
‘

The man aga

of the

first

twenty subjects

is

mm age of the last Went): is 143.
To osmium in this vein, I am calling m in
and asking that he cbtain surpass of the enigma].

23, and the
New

mm

York

of these
subjects andaom themtoma foramviewbybr. 11:11. Ihope, in
ms way, to get a better pictum of why this diffemnce appears

inthe m1yzormomd.1tisamyintmatingﬁndingandwe
ahmldtmckitdwn. WhenIm,Iwillbringadeckafme

social data so that you can add
Hospital tape.

this Maximum to the Hillside
Sinmmly yours,

m m,
Director
Mleg

M.

D.

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Dr. Dom

J.

1965

Clyde

Unimity of Mimi

P. O. Box 8293
00ml Sabina #6. momma
'

Durban:
Emlosedisadmftaopyofthemportwhichwill
hepasmhdﬂﬁomkinﬂwhxk. Imalsoenclosing

amofﬁmtabhsﬁmtwﬂlbedtstrdbumdtome

Imuldappmciateyammtssomtlcm

writaafinaldmttwhenitmm. Mybestmgu'ds.

8W1}; yams,
Max

Fink,

M.

D.

Professor of Psychiatry

map
one.

�</text>
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                    <text>thy 28,

Dr. Dem

J.

1965

Clyde

Mmity
P. 0. Box 8293

of Mimi

Coral Gables us, Florim

merDean:

I

Emclosed is an “male of
would be grateful for your

used here.

a recent computervfm analysis.
reading the method

mm

mesMyrasbemmysmeefulinfomingustodevelop

m the program necessary for such dimiminatima. We are
now planning similar amlyeee of psychotropic drug effects and
of cerebral stimlan’cs in volmteem.
My

best regards.
Sincerely yours,
Phil Fink, M.D.

HF:jm

Enclosure

meessor of Psychiatry

�</text>
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                    <text>July

Dr. Dean

J.

30 ,

1965

Clyde

University of Miami
P. 0. Box 8293
Coral Gables 1&amp;6 , Florida
Dear Dean:
The simple problems. I have received the enclosed inquiry
frat: Dr. Words regarding your correct title for the list of
omtributors to the forthcoming volmnc for Biological Psychiatry.
Would you please writs directly to its. Pbrford indicating the
identification you would like to have in that publication.

Earlier this week, (muck Hall visited me and we spent a
pleasant but puzzling day. He mviowcd some of the Hillside
mterial, and is pmscnting an interesting report to the

I could
of our
data so that he could continue his explorations of the effects

American Psychological Association . Neither Don nor
be sure mat he wmted exempt that he asked for some

of drugs

on EEG.

I am always plcascd to have people work on our data and
so have agreed to send him the material of the SKF study,a
copy of the progress mport I believe I have already sent to
you. (If I have not, I will be glad to do so.)
What

is

going on?

Thom must be some occasion when
My

we

can

met. men?

best regards.
Sinosmly yours ,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Mamh 1, 1955

Dr. Dam

J.

Clyde

thivmity of

Miami

P. O. Box 8293
Coral Gables R6, Flemida

Barman,

W
Impmdmmmowieaofamlofour
Smyemagowumimmmnminomvimingm
EEG
of
digital mum analysis of

that

wmld be

promdﬁmnonmdlhmjuatmleted,asmnasa
Mmofmnpwtmtmmﬁzmﬂmiealwmosim.
Ihopetheaeinmmtywmdﬁut mymaypmve awful.

Ifao,thun1wdnbamtifiedt‘mtinasmanwayImyhave

mpaidymrintemstamipatierminﬁmpast.
My

best

mm .

Sinoemly yours,
Max

Fink,

M.D.

meessor of Psydxiatry

mm
moloem

�</text>
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                    <text>Mardh 23, 1967

Dr. Dean

J.

Clyde, Director

Biometric laboratory
University of Miami
P. 0. Box 9175

Coral Gables, Florida 3312“

DearDean,
Thank you very much for your kind invitation to participate
in the seminar on computers in psychophamacology. The end of
April is a difficult time for us, but I have written to Don
Shapiro to ask wrether he would be able to participate.

to the programs, we sunmarized the best that
available fmn St. Louis in the publication which you
received a year ago. In addition, we have one progran for
library retrieval, and I think you have a copy of that. Are
these specialized pmgrmxs of interest?
With regard

we had

Thank you once again

for the kind invitation.
Sincerely yours ,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

�</text>
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                    <text>7mm...“

«‘w‘vwal-V—r-rww

47mllw~wmmNWFVu&gt;v-'

,

.u

-7.
p.- wsznw yww—rW‘--.~W»ml,..yw—,_w_.m

V—...V..v...v_.v‘n,.v...,v

r” --. w...‘ n.

.

-mv~—~m;.

w..-v..4.—.A._._.,V

—a-n—_.

,

«r

w,‘

w."

u—

.vmmnwr.

”mum,”

ju
A.

-V‘y‘

June 26 , 1967

w,a1'w"f(wm’1—'S

Dr. Dean

&lt;

J.

Clyda

University of Mimi

P. 0. Box 8293
Coral. Gables 148, Florida

DaarDean,

Itmaplmmtodiawswmmandlm
gratefulformintmst.
Wﬁawpyofa
clinicalmportafthedatagasmllastmsmries
data. Mmtwialmaygiveyw
oftmimanalysis
and discussion.
the
for

W
W
IlookfomardtoavisitinﬂewYorkatm
analym

mnastopporttmity.

‘

Simemly yours ,
Max

Pink,

Manor

Em:

CDT Report v: 5-27~67
Mums 3-9~66, 3-10-66

cc: Dr.

WM. Itil

I‘LD.

of Psydﬁatry

u—"umu-uv...«NMW

.._~..‘...M.

,.

v.7”.

.7

n".

_

. A."

-w-...

�</text>
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                    <text>May

l0, l968

0r. Marguerite Lynge-Larsen

Drug Addiction Treatment Center

New

Jersey Mauro-Psychiatric Institute

P. 0. Box 1000

Princeton.

New

Jersey 08540

Dear Dr. Lynge-Larsen:

Enclosed is a copy of our presentation at the American
College of Clinical Pharmacology and Therapeutics and two
other reports from our addiction program.
I trust these will be helpful and
additional service, please write.

if we

can be of any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kp

enc.

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1969

Dr. Dean J. Clyde
Clyde Computing Service
Box 166, Coconut Grove
Miami, Florida 33133
Dear Sean,

It was a pleasure to talk about our common interests. I
discussed the laboratory data form, its output and statistics
with Don. He is still not ready to release the programs, since
they require documentation. He also are dissatisfied with the
format of our outputs, including the statistics and are continuing
to work on them. As soon as they fulfill our present expectations,
I would

like to send

for your critique.
service to industry is

you samples

Your idea of providing a
admirable one. Good luck!

.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

“7”,.

.
v;
A
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                    <text>October 11‘, 1966
Dr. E. Craig Coats, Chairman'
Coumittee on Admission
The New York Acadany of Medicine
2 East 103 Street
New York, New York

Dear mu Coats:

Iwillbepleasedtoappearbefomﬁermmittee
The New York Academy of Medicine on
Wednesday, Navanber 2, 1966 at four o'clock.

on

mission of

Sincerely yours ,
Bin Fink, M.D.

Professor of Psychiatry

..A._..

.‘F‘...—x‘.

7.-

“PM

10029

MF:kp

'

�</text>
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                    <text>N

wr&lt;.q-~&lt;

v,

.rv.”

«WW—m

W

December 9, 1975

:

c.

Jlf

;}

"

~

5

.

A. CObb, 14.1).

Assistant Protesnor
university of California, Davis
Department of neurological Surgery
School of Medicine
hBOl X Stroct
Saorsnonto, California 95817
Dani Dr. Cobb.

..,F

The

material.

is

on exporinontal compound
two clinics in the
(Dr.
S.
Ferris) 1nd at New York
Univorsity
Mbdical College (Dr. R. ﬂornbush). Both are foouasod on single
trials in umbulntaeyy»outpat1onts and are at loust two your:
away from multiple aone triuls.
ACTHszjg

trials in elderly patients in

now in photo 11
U. 8. ~ at How York

I regret thut the ortiole ruined premature hopes.
Thank you

for your inquiry
Binoorcly yours,
Max rink,

M.D.

Jrofbsaor of Psychiatry

�</text>
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                    <text>January 16 , 1967
Dr. Joseph Cochin
Boston University School of Medicine
of Ptmmoology and Ecperimntal

Wt
Matias

East Concord Street
Boston, Massachusetts 02118
80

Dear Joe,
*

Thank you very much

for your kind offer to assist us in

evaluating the data caning from our laboratory. We have just
ooupleted such a survey and find that many of the questions

whichwemraisequuimsaneprelimixm-yworka atthe

College. As soon as the adjustmnts are nude, my associate,
Dr. Richard Remick will be in touch with Mr. Mushlin.

Incidentally, I do not think that the expenses suggested
matallexoessiveandwewillbegladtotaveyow
confirmation of our data.
Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mchp

�</text>
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                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics
East Concord Street
Boston, Massachusetts 02118

80

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.
You know that the
published in §gience.

summary

much

of the proceedings are to be

Also, I am sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
My

best regards for a pleasant

summer.

Sincerely yours,
Fink, 32M).
Professor of Psychiatry

Max
HF

:kt

enc .

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                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics

80 East Concord

Street

Boston, Massachusetts 02113

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

thet the
in
published
§c§g§gg.‘
You know

summary

much

of the proceedings are to be
’

Also, I am sure you heard that ﬁnds (ouront) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the Week the edict was rescinded.
Supplies are assured for 1 year was reported-by the New York
Times (July 14).
—

~

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, ”.3.

ProfesSOr of Psychiatry

MP

:kt

one.

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                    <text>April 22, 1%6

H». G. H. Goran

Dapmm of

.

4w]. Engineering

of Rochester
mimity
Rochester, Haw York 1&amp;827

mm.
Dr.

00318112

Fella-wing the

mat

in sauce of February 25,

MimMImpleasedmsubudtmabstmctdeamibing
1966

our dommntatim studies for yam
Rochester Gad-Emma.

mMemtim for the

hmmwthntﬁaiasumymhasmwpmmtothe
processing and mtmeval.

problem of bamdioal

11mm

Wamtﬂﬁsmts

to jcinmg you.

wiﬂzymmappmvalmdlook forum
Sinosmly

yum,

ﬂax Fink, NJ).

Profesaar of Psychiatry

�</text>
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                    <text>_(

"

'u‘n

'

.

,

.1

4.,

‘W-‘“

w-vmo waswmrw—WWW
)2

-

'1‘.’

January 14, 1971

War...“

60th

Dr- K.
Koxhor 11
Amsterdam

Dear Dr. Cohen:

Dr. Peter Geerlings visited on this wank and in charing the
descriptions of our programs in substance abuse, we found much in
common including an interest in the long term effects of cannabis
(hashiah). When I doacribcd a project we are carrying out jointly
with the University of Athena, he told no of the presence and
possible availability for study of chronic hashish users in
Amsterdam, and of your studies. Our project is to assess the psycho»

logical

and nourophysiological status of chronic hashish users,
1965-48 and to be rc-oxamined by us this

identified originally in
summer.

It may be particularly useful to carry out parallel studios
in another population. Is thero a population of chronic hashiah
users who can be idcntificd, and who might cOOperate in acne
would you with to estimate any characteristics
(age, duration and amount of use?)? would it be of interest to
you to discuss such a study?

examinations?

I plan to be in Amsterdam in late March and could arrange to
meet to discuss the project in Athens, and any comparison in
Amsterdam.

in

Dr. Gearlingc sends his regards:

March.

he

indicated he
‘

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszt
cc: P.J. Gocrlings

would

return

�</text>
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                    <text>January 29, 1991
Jay Cohen, MD.

FAX: 305 321 8024

Dear Dr. Cohen,
This letter is with regard to Mrs. Sandy Ruttenberg of Pittsburgh, who
has sought your advice about a gynecological problem.

About a decade ago, Mrs. Ruttenberg had symptoms referable to the
CNS and in an examination, an abnormal electroencephalogram, consistent with
seizure disorder, was reported. Phenytoin was prescribed, with the admonition that
it be continued indefinitely.
After a number of years, she sought advice as to whether such treatment
Re-examination and repeat EEG found no evidence of CNS
terminable.
was
disorder, and phenytoin was discontinued, without recurrence of CNS symptoms.
Two years ago, she again experienced some symptoms which couold have
been of cerebral origin. Neurological, EEG and other imaging tests failed to define
a CNS lesion or disorder and no treatment was prescribed. Her symptoms remitted
and she has not had other CNS symptoms since.

In the absence of neurological complaints, there is no reason in this
experience which would preclude her receiving any treatment for a gynecological
disorder, including surgery requiring general anesthesia.
Sincerely yours,

Max Fink, M.D.

Attending Psychiatrist

�</text>
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                    <text>August 15. 1969

J. Cohen, 3.x.
Dirsctor, Departmsnt of Education
National Association for Practical

Miss Michelle

Nurse Education and Sarvica

1065 Broadway

New

York,

New

York 10036

Dear Miss Cohan:
Thank you for your invitation to participate in the program
on my calendar and I
on wsdnasday, October 29. I have marked

it

will be pleased to present our experiences in the treatment of
opiate addiction at 2:30 p.m. at the Starler Hilton.Hota1. I
will try to adiond the meeting early enough to hear Dr. Brill.
A copy of my curriculum vitae is enclosed. my present
identifications are as Professor of Psychiatry, New York Radical
College and Director, Division of Biological Psychiatry.

Sincerely yours,
Fink, M.D.
Profcaaor of Psychiatry

Max

�</text>
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                    <text>October 13, 1969
Miss Michelle J. Cohen, R.N.
Director, Department of Education

National Association for Practical Nurse
Education and Service
1465 Broadway

New

York,

New

York 10036

Dear Miss Cohen:
Thank you once again for your kind

invitation to participate

in the National Association for Practical Nurse Education program
hesitate to accept your invitation for lunch
on October 29.
I
am
not sure that I can be away early enough; and plan to
as
the
meeting in time to hear Dr. Brill at 1 p.m.
join

presentation will be informal, and I do not ordinarily
written text, but use notes which are not
intelligible to others.
ﬂy

read from a

It is

intention to describe the programs for the treatment
of opiate addiction, including an overview of the various
my

rehabilitation

but emphasizing the
pharmacotherapy - rehabilitation approach. This View, which
includes the methadone, cyclazocine and naloxone antagonism
treatment research projects, provides (we think) the second best
and psychotherapy programs,

dilemma. (The first is prevention.)
come from our laboratories at the
New York Medical College - Metropolitan Hospital Mental Health
Center and will be supplemented by the studies of Dr. hole

to the addiction
data presented will

answer

The

at Rockefeller University.
present methadone program.

I

will also discuss the Hayor's

sufficient time for discussion and questions
floor. If a slide projector is available, I may be able
to present some of the data from tables, but this is not essential.
There will be

from the

(Slides are
I

2 x 2

inches.)

trust this is helpful,

on October 29.

and I look forward

to seeing

Sincerely yours,
uax Fink , 3m.

Professor of Psychiatry

Mszp

you

�</text>
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                    <text>May

29, 1959

Dr. Sidney Cohen

National Institute of rental Health
5451+

Wisconsin Avenue

Chevy Chase, Maryland

Deer Sid ,
Following our

dismiams of a

long acting form of

nalom,

Ihadocoasimtoepeaktorr. Waboutevieitthatl
had carpleted to the University of Mime. I suggested that
itwwldbevaluable toserdatemtoAtlmstoemdy this

years,
group of patients who have been taking marijuana for many
and to define, if poesible, the (magma of brain change which
my have occurred.

sufficiently interested to call Dr. Yolles;
the matter was referred to Dr. Filler; consequently, Dr. Miller
today suggestedthathe joinusatmmmeetingmﬂmday. I
amencloeingacopyoftheobeervatime as Importedthemto
Dr. Freedman and my menu: to him regarding a proposed project.
Time permitting, I should like to discuss a cmtrect for
amarijumastudyinAmem andacontract forthe studyof
nalomne in a eilastic vehicle to extem its duration of action.
6136' Separately, Dr. Preednm has written to you requesting
large scale study of the clinical,
m extentim for a proposed
CNS
aspects of marijuana to be mdertaken
logical and
in this laboratory.
yoreeeox. o; Lehcprgxzm
Dr. Medium was

1m

2.3.1110 II-I'D'

gruoemﬂx home '

more ens 911A bmpjeue) °
page“; euq any p6 erghmfi

to

94: 4:116 (316M (31926 pacer. 1-0qu II
a : 30 9131’ Jynmqgh (I MIN p6 mum'ﬁ was nrﬁp;
14: 3'00}? 3mm ms nigh game e pnel 110me
I 3'00}: Louver;

366211.13

DL' @3161!

hon

g;

-5-

gm sa’ Iaea

�-2-

Dr. Cohen

29,

May

1969

Itlodcslikewemayhaveabusymrrdng. Ilodcforwm

toaeeingyouatQ:30am,'nmsdq(Iwillbear-rivingﬂnnight

befmmwﬂlbostwﬁxgatmomumemwwdgaif
Wmmypmblm).
Sincerely yours ,

m
m. of Psychiatry
Professor
MOD.

1'”

M8

NPOUROIA‘

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wquwgmcmeqyuﬂcmaumozqn

one.

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Mb 0; baggage tape was pew 5W £191;an wank hm'
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�</text>
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                    <text>"ix-‘3 r-

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r'v na—u

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.

.

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,,H~mwx-..~w nu we! can ;.,- hr.

October 12 , l966

Dr . Robert Cohn
U. 8. Naval Hospital

Bethesda, Maryland

Dear Bob,

I have been interested in
the EEG, and I am most
of
counter analysis
interested in your report in Denver. Is a
preprlnt available?
Many thanks.
As you know,

Sincerely yours.
ﬂex Pink, ILD.

Professor of Psychiatry

Hszp

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                    <text>July 9, l968
Mr. Thomas M. Colasuonno.
Alcohol a Drug Education

The Western

Institute of

Summer School

Director
Drug Problems

P. 0. Box l491
Portland, Oregon 97207
Dear Mr. Colasuonno:
weeks ago we responded by sending a copy of my
curriculum vitae and photographs to Mr. Don Short. In
response to your recent request, I am enclosing a short
autobiography and a copy of my complete curriculum vitae
for your use.
Some

Since the presentation will be a summary of our experiences
during the past few years and an overview of the work of others,
no formal paper

is available.

To supplement my remarks, I am

enclosing copies of publications and preprints recently completed
in this department which will be the basis of the presentation.
The focus of attention will be on the problems of narcotic
antagonists in the treatment of opiate dependence and the most
relevant material is summarized in the preprint “Antagonists in
the Treatment of Opiate Dependence" and "Narcotic Antagonists
and Substitutes in Opiate Dependence.“

like to arrive

a day or two prior to the actual
appreciate a copy of the announcement of
the Institute and a suggestion as to the nearest motel accommodations.
As

I would

presentation.

I would

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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                    <text>June 25. 1968
Mr. Thomas M. Colasuonno,

Alcohol and Drug Section
Mental Health Division

Suite 300. Tenth
10 N. W.

Director

Avenue Building

10th Avenue

Portland. Oregon 97209
Dear Mr. Colasuonno:

Last week we received a phone call from
the Public Relations Section of the Division
requesting the cirriculun vitae and photographs.
These were sent and I trust that these are

satisfactory.

the

be
it
announcement
would

Drug Problems?

possible to send

me

a copy of

of the Western Institute

on

Sincerely yours.
Pink. ”.0.
m
Professor of Psychiatry

Mszp

�</text>
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            <elementTextContainer>
              <elementText elementTextId="33962">
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                    <text>November 10,

Dr. Jonathm Cole

19811

,

National Bank Building
6917 Arlington Read

Bethesda. Maryland 200m

Dear Jonathan:

every pleasant visit from Dr. Prion
today.
visiting Dr. Mles and I
took the Oppommity to acquaint him with some of the
operations of the Institute . Wren I asked whether he
We

had

As you lmcw, he was

had seen our

to the

letter of

NW 2nd rega'ding the addition

Collaborative Chronic Sdiizophrenia Study,he
said he had not, because he had not been in Washington
PSC

duningthepastweek. Itookthe liberty, therefore, of
him an upper11:11
Dr.
and
perhaps to provide him with
tmity to met
some of the background information which may be of help
to you in making yew evaluation.
discussing the proposal with him and giving

Last week Dr. Ulett called you regarding an
extmion in time for a proposed E. C. D. E. U. application
from the Institute. I have taken the time to write such
an spplicetim but find that the fwds requested are
I became keenly aware of
relatively large in
the fact that there are two proposals before you regarding
additional funds for the Institute. Last amth we submitted a supplementary request for MH~072149~03 in the sum
of $38, 307.00. Also, in our letter of lbvesber 2nd we are
suggesting another supplerrent in the
of $34,1t50. 00

mt.

wt

for the additional data in the collaborative sdmizophmnia

study.

While

I believe we could successfully undertake

an expansion of our E.C.D.B.U. program I am concerned that
submitting a large E.C.D.E.U. application may prejudice
our earlier supplementary request. For this reason, I am

hesitant about submitting this application at this time.

Inf/ls

Sincerely yours ,
New Pink, PM).
'

Director

�</text>
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                    <text>May

RE:

21,

19614

MbRGB~PSC
W1 08517-01

m 08597-01

Dr. Jonathan 0. Cole
Psychqahamacology Service Cantor
Researm Smut 8 Follwships Brand;
National Institute of Mental Health
Bethesda, Maryland 2001*;
Dear Dr. Cole:

name you for authorization to amplete the
laboratory equipment Headed for our £3ch Unit. Attaclmd
am lists showingtheitmizedmstbmakdmnoftm
forum grant.

Wes

Wedomthavefmdsinmeequiwanteate-

germs of these pwjects far this purpose. We
to change these items against the funds originally
designated far manual. and available Means: of delayed
recruiting chaﬁng the first year of the gmnt.
mam: you.

Sincerely yours ,
Mm:

Fink,

Dimmer

H. D.

�</text>
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                    <text>Mtg 25. 1965

Dr. Jonathan G. Cots

Psychophsmcslug

8cm“

Rs: mic-08517

woman-02

cents!-

lstionsl Incite-ass a! Bsslth
'm‘ioasl Isak Building

“than. Xsrylsnd 20016

Bur Justina:
writing to obtsin psmission to trusts: funds from the
a
hams! estuary to tbs Equipment: usages-y. dividsd half»

I

in the sun of $10,000, :0
m grants,
m lsbotstory to any on: tbs
to: bash thus studies. 1: nsiths:

md-hslt bstmn thus

psi-nit

Is to squip moths:

«wading «usury
prooriginsuy mustsd for tbs sstsblishnsut
Ms
«rs
of no lsborstoriss. Es hsd 91mm: ta utiliss tbs squig—
nsnt providsd by tbs ants a! Missouri for tbs studiss. To
gram

for tbs m clinics}.
"sand
tumibilieiss
‘0!
Louis
tbs
St.
Suns Hospitsl. than hsd
must-aria

do

so, vs

sheetmcsphslmsphs and ta this was
vss ymidsd by ths origin“ funds at

m

sddsd ms sets whisk
chs muons-i Instincts

of Psychistry. At tbs pus»: sins, thsrsfors. than srs
thrss lsbotswriss squippsd with slsctruncsphslssrsphs.

cm: s! tbs instmts m psrt of the clinics! pro»
Mn.
gun at tbs St. Louis Sum Kospicsl and um Hissouri Instituts

of Psychistry sud an dmtsd lsrgsdy to obtaining clinics}.
nuns-is must“! by our consultants ss vsll ss by snubs" of
stsi'f. m. third has Essa in sxtsndsd us. in tbs program
I]
07249, sluts vs hsvs bssn shit to "card my «cards on

nan-tic tsps to: can-puts: snsiysis.
its has nanny opmd s m lsborstary for ths asssurmnt

o! svoksd potsutisis, ss «scrim in the program 08517. It
me regarding
is imam: in this study ta abuts
of tits eliaicsl lush-muss
sad it is cur dssirs to 91m
in this lsborstoty. To kssp sbrssst of tbs rsquirasnzs of ﬂu
programs in @8517, 07149 me also than inhsmt in tbs man
lsry programs organism! by Dr. Gsrshou sud nysslf (08597) . it:
is musssry tbs: us squip moths: use Isborstory.

m

meth

�Dr. Jonathan 0. Col.

5.25-6k

‘

Yuan Th0

lull staff for ah. progran 08517 will ho convicttd this
Jana. Scenes. of ch. dnlayu 1n nppotntunnt of scientist: to
thin program. an bl». nvailahlo fund. in thc rut-canal eucasory.
It is than: funds that I II tuquoatiux pcrniluian to trcnsIQr
(run Pursuant! to Equlpnnnt fer eh: purpolu of obtniuing ch.
lullavtng;

tho

Grass Nodal 6 81cctruaaucphnlnsrnpb, conealning
12 chauanll of EEG, and 2 nc channnln. ﬁt at:

‘

for a

chanaal instrunnuc to pornlt an
to continua our grail lurvnyu in our drug research
and to pruvidn autftclunt tlcxihiltty for concurv
tun: nun, 1y. IuVInnnc. EKG, and raupitntnry rut:
rucotdln; as thnlc It: anecsslry during ch. acacmaking

12

adnﬁntntrnttou of any compounds. this aquipncne

it

pricad 1: $9,500.

In addition. it will be noeuaaury to obtain a variaty at trana~
anus!» and son: anutllnxy nqulpntae oneh varying tu'ptiea {can
$125 an 8200. to: I total an: o! 8800.
All 0th.: piano. at aquipulnt tannin-d for such g luborntary
tuck ll chairi, dunks, acc., an. «willnhlc at the Htasaurt
Instituto of rtychiatry, obeninqd through sh. hudgdtu of thc
Inatltuct lane your.
81sec tho aqulpunnt‘uill ho used both for ricordiug with nan

aoupounds and for euntluuuus nurvuyn of an: chronic anhlson
phrnnie population. I bultcvu it would he :ppruprince to
pct-l: a: to ehnrxn.both grants. approxluneuly equally.

thank you vury Inch

to: ycur aonstdnratton.
Sine-ruly yours.

‘4“ “Bk, “‘3.
Bitten»:
”Fish

�</text>
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                    <text>Juno 3, 1966

o. (bl.
mm
I1,
mImam:
m01mm Halt}:
mm, Mind
“‘0

W
3m

~

5

2001“

W
Wmhmmofmhm.
mmnmm.
Dun-mm.

MWmth-“Clmmszwuofmiwimm

:wmuummmmmmamorm
Ithimtitm
Sincerely yours,

Mm:

Firm,

14.1).

Professor of Psychiatry

mzkp

-

unprw

ﬁn‘ww‘wr-

.
.

�</text>
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                    <text>73AP-827AP
20 December 1973

Diroctor
Hationnl Institutes of noelth
9000 Rockville Pike
Bethesda, Maryland 20014

Roz

Departoont of Health Education

end welfare
Rational Institute of Health
Protection of Human Subjects

Policies sod Procedures
Flgeral Register. Voluno 38,
Fridoy, Rovouber 16th. 1973

D“! Sit:
behalf of the Anorioon Peyohopathologiool Association. we
request an attention of ‘30 daye of; the time to reply to the pro~
posed polioioe noted above. This extonsion would permit us to
contider tho ieeuce roiood in the proposed soi‘olineu at our enuual oneting in March.
On

The proposed regulations are unusually important in that
they any iapair studies vital to the health of the citizens of
our nation. rathor than eneourege than. The issues extend be~
yond the imoodiate problems of monitoring the human rights of
children and the nontolly 111. Because an believe that the axonoies involved have sivon much thought to the production of these

it

bolievo it impossible for us, as well as others.
suidolinon,
to respond mooniasfully in the tow wueko einoo the policies were

publiehod on November 16.

If such an extension is granted, and I hope it will be. I
you will have e constructive rosponao from thin Association.

believe

Sincorely yours,
Fink,
President

Max

MF/oio

bcc:

Dr. Leo

Hollister

M.D.

#221

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                    <text>..‘

”My“,

(r
.

”aw.“

V

V

u“

w.»

w. -....»_.w..——..t_wwv...r.—.../......—.,»

ur.“lr-~‘an!~‘.v‘v&gt;vn .0.

mu

7

,.

-

. Hay—rm“ awn—"q... .,‘,,

v...“

_

v

7333-77653
16 Rovoubor 1973

Leo

V.A.

Kolliotor,
Hospital

H.D.

Palo Alto, California 9&amp;304

Door Leo:

I box. just roturnod from a visit to Professor Stefania
ot the University of Athens and hero roviowod with him the
data of our collaborative study, "Chronic Hoohish Users in
Greece." This stuoy hos boon in progress for almost three
our presentation of data to the
years. and an hove limited ACE?
ana
CIR? in Copenhagen
mootinan. I bolievo the data
the

demonstratos some of tho hazards of loog~torm hashinh use, in—
cluding the developunnt of tolerance. Protease: Stefania is

interested in prooentina this material at appropriate nootings.
I understand that you are organizing a symposium on drug abuse
for the 197k CIR? mooting in Paris.
Shoal! it ho appropriate, and consistent with your dooizns for the mooting, perhaps you would consider inviting a
presentation of theoo data at that meeting. I holiovo that
Dr. Stefania would want to make tho presentation, which would
b. oo-authored by tom. of tho inmostigotors from the United
Status ané Athens.

,2

,

My

.4

”mm

boot regards.
Sincerely yours,

no,“

,

mar“.

”I;

piﬁk, Nob.
Proton-or of Poychiatry

uwwrﬁwwq.rﬁwn—r~.u

MF/cia

co:

C.

Stefania

5. Stars

�</text>
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March 29, 19Th

Bettie MbLeod
Clinical Psychiatry

M8.

Hews

h907 Cordell Avenue
Whahington, D. C. 2001b
Dear Ms. MbLeod:

Enclosed is the galley proof with some corrections. I
have added a paragrayh which may put this presentation in a broader
context. One paragraph is marked as ”out of context" and probably
should be deleted.
A

Be

photograph

is included far your use.

sure to send

me

a copy of the newsletter.

Sincerely yours.
Fink, M. D.
Protesaor of Psychiatry

Max

Merd

Enc.

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                    <text>May

Dr.

J32r—3-‘3'vx‘3r

Jmathan

National

mama}:

6917

Bank

Gale

Arlingtm

Building
Read

Bethesda, Maryland

my

J

20, 1963

~
'

113”sz

Iplantobinwaﬁiingtmfortmmcmf'emonthe
103)!

Microthesmm. Jme SM). 1963. The conference
By that tima I swuld have: much of the information
our applications either sent to you, or in sufficient fem
for m to bring. I should like tha oppommity to meet with Wu and
Dr.
on the morning of June 6. If this is mt fewible for
yam, is than any manage to meeting with Dr. Commas or anotm
maker of your staff that naming to help clarify the my questions
which almdy have arisen, and which will arise as we get into pmu»

begins

_

at

mm

12:30..

mass

paring

than program

with

Sam

Gershon?

Sincerely yours.
Max

Fink,

Dimmer

M.

D.
&lt;
&lt;

:ﬁaaginamaak

�</text>
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                    <text>May

31, 1963

Dr. Jonathan Cole
National Bank Building
6917 Arlington mad
Bethesda. Maryland
Dear Jon:

copies of Sam Gomlm's
m ﬂame.
and m. comm.
Segal
Ir.
Wolf.

Encloaad

proposal, for

I look forward to seeing you

My

Sinmmly yours,
Pink,
m
Dimctor

Hfzjr
Enclosma (3)

M. D.

�</text>
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                    <text>Jonathan Cole, M. D.
National Bank Building
6917 Arlington Road
Bethesda, Haryland
Beer Jon:

conference for the development of
e peyomphysiology
it became apparent that such
a brainstorming session can produce the necessary first approxinntion to the psychopharmcolow mimﬁzes’aurue. Rather than
wait for Dr. Welt or for a subject listing to appear ”by accident”,
While

attending the

mmm,
BBC

a

W

wmldycuamsidwcmtactingmmetaffandmengeajoint
ﬂeeting to
e MWums?
Working with we may be helpful because they have carpenience, and seem willing to update such comments by trial.
&gt;

a conference could be held in Washingtm early in the
Fell or before the ACNP meeting; or. a pilot meeting held in the
Fall and a final acacia: at ACNP.
Such

As chairman, Welt may be

the logical choice.

If this interests

you, the BBC chap in charge of such work
is Mr. Paul T. 0' Day, T18, Arlingtm Hell Station. 525-5800,
Ext. 785.
Good

luck.
Sincerely yours,

Firk,
Director

Max

Hr:jr

M.

D.

�</text>
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                    <text>July 1.

1963

Dr. Jmuthm Cole
Natioml Bank Building
6917 Arlington Road
Bethesda, Maryland

DurJon:

last fewvaeks. ainoemyvisittoﬂaahingtm haveboen
tted thus
quite buayarﬂSm,'nmndehavu mhtcdands
NIH.
those
to your attantim.
I am writing to bring
applicatima to
Those

The

applicatims are:
1.

Sam

Santa:

and

Max

Pink; ”Antagonists to Anticholiiwrgic

Payehotomimtics”. This application is for the smy of new commas
animal studies,
using antagonism to ditran as a amen. It
and
clinical
drug evalmwith
P30,
early
toxicity study mm cmtmct
tho
application which you
tian of any new semantic dewloped. (M8 is
'

amazes

ainceIamamborof
tmughtwouldetogotoaspocialmitm,
the clinical
oomittae.)

of the Lithixm Ion”. This is
forward application for testing of efficacy of Lithiun and ml
athestraight
and associated
mumm- min using ahlmmmzim as a cmtml;
(1115.5
application
the motabolioﬂ. studies, all under diztary control.
was the one that you thwght would go before the regular psycnophamaSan Gamma; ”Psychopharmcology

2.

coloy

mince.)

Itil
This

Tumn

3.

and

Max

Fink; "mempy Resistant Psychosis and

mm". It is directed to determine the mlevanm of mmphysio—
msistm.
logical factcm and mama“: failm. (This is an application which
d 30 to tha cliniml mittoe as it falls within the.
logically
ismpmgmmtostudythopmblenof mamnt

prom in mien the mitt” mead an intmst.)
,

I

would be very

eaeh of

than

grateful if BightVisita

prom.

would be arranged for-

�Page Tm

In".

Jenatm

July 1,

Cole

1963

successfully engineered his three treatment eentem
Hiesouri
through the
legislature. In additim. he achieved the
approved by the Seven-m for the Institute. We are
full
George

8W

allexoitodbeeausetrmsuppomgimhiminehemmofthe

politicians in Missouri.
501 has joined the staff and with mat of the
hurdles overcome, we are mw getting dam to serious research
I plan to be in St. Louis mtﬂ midoAugmt. If the oppommity
presents itself for you and Cathy to visit with us, Martha and I
would be delighted. I have just termed from driving Martha to
New
Yorklm she is spending ten days. I expect her in St. Louis
esteem which he has developed amongst the

Wmﬂve

m.

W July R.
My

best

mm.
Simmly

yummy,

m
M. H.
Director

De

�</text>
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                    <text>W
lb. Jomtlun

National

6917

Bank

Cole

‘

6,

1963

,

Miding

Road
Mam
mum

BOW,

Dear

Jmnﬁm:

Bath Sam and

‘

I

have:

NW“.W
m1: my be: a
mat seem to

good

read Dr. Gallmt's paper on

triﬂmepidol.

om

subjaet for discussion. ‘Ihn only
consideration am the bmzquimlizims ma
'

Ihaveremndad'mmnltilandmsemimtoﬂum.

Whammated amther smorandImuldbegmteful
ifyoumldmimspmsoringSmm‘mmnasweu.
Ifyou

Dr.

3.3thde

fulmtyoumlusaeqmimdwiﬁmw,
ask Hy Dunbar. 'I'miv mimlua vitas an enclosed.
will
We

am looking forward to seaing you in September.
Sincerely yours,
Pink.
Dimmer

Max

14sz
we.

24.

a.

�</text>
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                    <text>August 26, 1963

Dr. Jonathan Cole

Nation].

Bad»:

Building

‘6917 Arlington Road

Bethesda,

Wizard

Dear Jon:

I have read yaw u: w mm of August 16th and I am writing with
regard to the questim of site visits to the listed ECUEU investigatom.
For reasons of interest in the prom at Mane, I am plaming
to visit than timing this fall. Similarly, I have an interest in the
program being develoyed by Dr. Pfeiffer and would be pleased to have
an opportunity to visit him this fall as well.
Likeothermmbemof the smiths, Implamingtobeinzmpe

mdifyouwishtohawmﬁsit
mxtsmrforﬁmmme
Dr. meatly with you. I would 1’ it very interesting.
looking forward to seeing you soon.
Sincerely yours,
Max

11PM"

Fink,

Director

M. D.

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                    <text>September

a,

1953

Dr. Jonathan Dole

National Bank Building
69].? Arlington Feed
Bethesda,

mm

Ra: Hi 0728943231

Deer Jonathan:

Whemnapartmimmprojmmmd
Woman, m 072%. Since the application for the

Emma

supplmtmthtIdmlyinAwﬂ.mmomtiwedtowrk
mthispmjeotandluuewmminfomtimmmmpf
mhelptoﬂnaviewimmﬁtmeindetuminimmmritaof
mmpplmntarymmt.

Inﬁxemtmhawplmmmisapproved, itwuld
behipfﬂfwmﬂhnﬂditimﬂitmmimludedinm

Wmmst.

In Mable magnum, a sun of $2,380 tor tho fallmdngl
2

10
1

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mm: Tepae a m each

mm Gain mum» (probably

930.39

mm

name
1000.00

a%i‘&amp;§£$§?£££ﬁ
ammo?
emmio
im

and

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in the promo: apart.

he justification for the»

Sincerely

is

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9mm

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De

�</text>
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                    <text>October 2, 1963
Dr. Jonaﬁaan Gale
7111 Bdgavala Street
Qwvy Chase 15, Md.

Dear Jonathm:

yam

Imtnkingﬁdaopportmitytopemmallythmkyoufor
many efforts can halal! of the Institute. As I left your

mgudingmapp~
onmmymmts
greatdnbtthate‘wrge
and.Imym.not
Wmoftm
office

~

«ﬂy for your efforts in the grant programs
also for your fumble

If and when

Wﬁm.
this Institute is

Welws,' but

finely establishad as

a.

nuamhmnter, itwillholargelythmxghthes‘ rte!
mlikeymmsalf. Flemmptmypamomlm‘ man.
My

best

”gm;
81ml);

yours,

Pink, H.
m
Director

D.

�</text>
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                    <text>mm 28. 1963
11-. Jonathan Gale
National Bank Building
6917 Arlington Road

Bethuda, Maxylmd

Dear

Jmaﬂum

Wm

Aftor the staff 1mm at
Lhimity today, I met
withmmiﬁobins,8ammm,coomWhnkwdeaor-gcﬂxnyhyabout

thoda pnlhaionatudy Itookttnliberty.erurmeeivingtmdmrt

ammofgivingtmampy.
{b} $5344.64,

HJigzumcli'hiistenthsmom:mathsclinginganiononmtinuoc‘linthe
following Mn. The denim «and satiofaotory except that tiny

muldhavetoravemmimltfwbedeostadwingm
initial mid final make of the My.
A

their papulation is in tho Out Patient Departmnt
it was meaty for the antiodeproasion study
ally.
may can back to tho qmstion of bad costs. I sags-stud

major portim of

and they wonder mower
to ha in the in~pationt

that

M

Madly
aim this was an aminimﬁvo quatim, that it be dofomd mtil

thyhadmadommtsmgudingtlndosimofthestudy. may
Wtomiteam-ﬂmmmofmmofthesmdy
umﬂuﬂnirpopuhtim
Waristios, amorofsubjocts,“
gamma]. facilities. They some! intomtcd in participating in this
gmmduddﬂuttlnymuldhawtlﬁamttoyouwithin themxt

“m.best
My

magmas.
'

Sincerely yours,
1"” Pink,

Dinotor

H. D.

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                    <text>1

“yr-,4"!

w“;

j

a

’

\T‘

Novoubor 5, 1963

Jonathan 001-, H. D.
National Bank Building
6917

Arlingtm

Road

Bethesda, Maryland

Dear Jon:

Implaningtobeiankaduringmmmﬁ
wrimntonr. Sugamm Wm ﬂutImto visit
ande
mmmday,nccomber5. Piehasamodthatmisisagoodday
forhim. Wmldyoulikatoumdmofttnsuffalmgwithm?

IshallbeinﬁewYoxktl-ndaybofm,andshouldlikc

ymrpomiuimtomntacartodrivatoh'ime‘m. Thiaucm

maﬂymvuﬁmtwaymwmldfmemofmspedalw
involvedinoabsmdmin.
‘

Isthemmyspocial infmdm thatymwouldliksmm

obtain during this visit?
My

r

best regards.

Simly yours .
Max

Pink.

nirwtor

‘

Hf‘mlg

)1. D.

�</text>
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                    <text>{boomer

2M

, 1963

Jmathan Cole, H. D.
Natimal Bank Wilding
6917 Arlington Road
Bethesda, Hem/land

Dear John:

‘

It um a pleasure

talking to you this

ming.

'Ihe Missouri Institute of Psychiatry, in omj motim with
the amputat- center of Wasrdngton University, is going ahead with
the dovelopmnt of an infmtim mtrieval system. We mld like
to undertake the project on selective dissenﬁnation of infmtim

originally proposed by Mr. Dannkoehler and
01), which was withdrm.

m

Vanderplas (PH-07891-

I shmld appreciate the opporttmity to discuss this program
wimyou. Them isonemedwhichombapmvidedbyPSCintheoompleticn of its psymoPha'maoolow abstracts. Rather than having a
girl punch om, daplicating the material listed in the abstracts,
I would appmoiate having made available to m a pmdm tab produced

attrwtimtheabatmtamtypedinfimlfm. Wehavemeequip—
nent available in St. Louis to convert a punch tab into earth, and
this will markedly facilitate our studies.

I will be in Washington for the MN? mating of January
I am planning to take m evening fligat on the 15th,
I om arrange to be in Washingtm earlier that day, or stay over
Saturday afternoon. I would appmciate tho opportunity to discuss
16

-

18.

While

�Jonathan Cole,

H. D.

December 2t). 3.963

Paw

Two

om pmgmmwith
My

you our

son of your maoeiams during those days.

best wishes for a

happy and

healthy

New

Year.

Sincerely yams ,
Max

Fink,

Director

M.

D.

�</text>
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                    <text>January 2, 1963

Dr. Jomthan Cole

National Bank Building
8917 Arlington Road
Bethesda, Maryland
Dear Jcmtham
have remived a
of
his
copy
being a masher of P80.

I

letter of application

Wm

We

A

£11m Dr.

vita is attached. In

Jm-bi

Tu.

it he indicatas

appreciate any information you have regarding this
candidate, especially a clm‘ification of this statumnt.
would

My

best regards.
Sinmmly
Max

Fink,

Director

Wm»

am.

yum,
M. D.

�</text>
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                    <text>April 29,

1964

Dr. Jonathan Cole

Rational Bank Building
6917 Arlington Road
Bathaada, Maryland

Dear Jonathan:

ﬁncloued are

M1180

tlte visit reports for

Bra. Frladuan and

is a speelal problem in the 1r1odman application
rolntcd ta the question at the paynnnt of hospitalization
exgonans during the period whqn a patient is on placebo
tharapy. It is my impreasion thnt tbs two physician:
that I act would bo vary raluctant to racomaand private
patients to the :tudy unless that: feeling: of obligations
to the individual could he asauaged by toms maneuver such
as paynanc of hospitalizatlan costs. Those apptoxinate
Iannthlng less than $20 per day. It vauld be helpful 1!
you could clarify tbs possibility of such paynunt before
ch. Caunletco «seeing, since the availability of private
patients would be highly dependant on such a decision.
Theme

Sincerely yours,
Flak,
Director
Max

HF/jb
Ene-

M.D.

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                    <text>September 29, 1964
Jonathan Cole, M.D.

Re: Subject: 07249~O3
Supplement

6917 Arlington Road,

National

Bank

Building

‘Bethesda, Maryland
Dear Jonathan:

Enclbsed is our application for a supplement to the EEG and
Psychopharmacology pregram for an eighteen month period
from the period April 1, 1965. This supplement will cover the
full period of support of 07249 and, as I stated in the first
page of the application will permit us to complete the computer
trials for this program. It is my belief that the present program
using frequency analyze: data will give no answers originally
postulated by the Committee, but this computer program.will nake
these answers much more definitive.

Human

'If the application appears complete; I

sending

it

through the usual channels.

would appreciate your

Sincerely yours,
Fink,
Director

Max

mf/ls
enclosure

M.D.

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                    <text>W
Dr. Jmatim Cole
Retinal Beak Wilding
6917 Arlingtm Road

Bum, mm
‘m Jmetim:

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16, 196‘!

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submitted m-septeeber 23,
application for research
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31,

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1966.

'nmk you

Sincerely yams,
‘

nfgle

'

Max

Fink, Md).

Wire Director

�</text>
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                    <text>Decanter 1n,

19614

Jonathan 001e, M.D.
National Bank Bldg.
8917 Arlington Road
Bethesda, Maryland

Dear Jomthm:

.

This

letter is to

confirm our telephone cmvematim cf December 11.

mgmts

for e site visit to Gamesville on
have made tmvel
leaving the
1965.
Ivhnld
memtiom on ﬂigxt National 2198:05.
Smdey, January 17.
To be
Jacksonville
6
PH,
in
at
National Airport in Washington at
Jackemville
leaving
adeeduled
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have
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naming, I
in
time
Mimi
for Eestem 105, arriving
in
which
me
to
brings
etl2:§.(
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in San Juan“ 8:25. This visit muld require ﬂat

I

”FEW

mm

available early Smdeymoming mdthetwe mlete the visit in tin: form to
or should I,
be back in Jedcsonville byllms at the Latest. Will you write to
will
I
that
am
stay overto confirm their being available that naming? I pmeming
from
Jedcemville.
night in Geinesville, waving

m

Iwouldalsoeppreclctetheowox'tmity fwyoutoneetwith‘rmm
eftemom, Jmuary mm, to discuss iii-072% eupplezmtaxy
eswelleaowdatemgaminge
studyoftheeollebmﬁw admixopmveniapmgxm,
mique pmgzm of munch in a largely untreated powletim of mtelly ill in
and myself on 'mur‘sdey

Istanbul.

mutematiaml
Weplentomiveinaaltimetlws mdehouldbeet
ferns?

Imby3PM.

ledywbeabutoeetﬁnttimeside
Mybestwiehes fwtheNewYear.

Sincerely yours,
Hex

Fink, Md).

Director

mfzkd

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1965'

C010, Kobe
3mm
Retinal 3m): Bldg.

W,

6917 Arlingmm mad

Attmtim:

Maryland
Mrs. Gertrude Tedro

Dear Ms. Team

w.coleheeeelledmartmgeeeitevieitat

ﬁlielmtiurtimmmlst. Ibelievethetitwbe
helpfulfwﬂmeiteviaimifym.ortlwy,mto
fwmemﬂwetmmmtelwhimisw
ﬂametitute.
Imtckingtmlibertyofminge
Wendtheedzeduleofdm,w¥dmmompenble
tootherwteleintheerea.
Ifyeuprefer,mycemeterywouldbepleesedto
meleetheeereservetiencmbehalfofmpartioipmte.
Sincerely yours,HOD.
m
m,
Prof. of

Why

�</text>
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                    <text>March 19, 1965

Dr. Jonathan Cola

Rational Bank Building
6917 Arlington Road
Bothasda. Maryland
Boar Jonathan:

I an aabaraaacd that tha copies had errata on tha financial
tha bookkaaping office found thaaa. and they arc carraetad
in tha final application. Enclosad at: 10 copies of the corractad

pagan.

pagaa for tha_Xarox coplaa you hava.

Sincerely yauts,
HI! Fink, 11.9.
H131:

Profaaaor of Psychiatry

�</text>
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                    <text>April 1,

Ir. Jmathm

1965

Cola

National Bank Building
6917

Arlingtm

Dsar

Jmsthm:

Road

Bethesda, Maryland

w
ﬁndimsrmﬁidsyemim,
wmuy,
pslholidmmdaeImsittinghem
misismefmmwimipsl
you way

mm for your invitatim to participate in
Apt-5.115, 1965.

mmzingmysw,1findthatwmtawinbein
St. louisfozrﬂxsmlshmtim. Whilelmhmondbyymm

mmm,1mtaskywrindulgmoefw13hallhmto
flight for St.louis.

memtmuwﬁ

Servingmthismttaehssbemamatplsasm,an
Under
mksdsrshipmdthstofm.8ri111fulthatyouhmdme
panlogyintMWtedStstasm
indasdinmfonigaeomtrissasmn.
IfIcaneverbeof

mmmlopportmitymdamatmudingsxporimm.

mum
assistmoslwillbshamud.

HayIﬁmﬂcymforinclmingthislabomtmyinthelist

Itisalsoadistincthmorto
younmndsdtollnﬂsdmko
buincludadmmadiotinwmnsts
ﬂy

but

personal mgards.
Sinosrely
Max

yum,

Firm. H. D.

Professor of Psychiatry

�</text>
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                    <text>June 11. 1965

Dr. Jmathm Cole
Natimal Bank Building
6917 Arlington Road

Bethesda, Maryland

Door

Jamthm:

collaboration with Dr. Dunbar is proceeding. I would
appreciate a copy of the present protocol so that Dr. Itil and
I can acquaint ourselves with tho details of the project.
Our

Thank. you

very men.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

Hfzkp

�</text>
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                    <text>Bomber 19 , 1965

Dr.

Jmthm

(3013

National Bank Building
6917 Arlington Road
Bethesda, Maryland
Dear Jonathm:

Tm has mm from the New Orleans mtings with a

manlofonthusiasmmdlmttothaakyouforaxtending
unable 130

this invitation. I

vagrant

that I

Wt

was

mating of our Paymiatrio Research Pomdation
that: I be there.
Friday and it was

attend but the

was held on

Yum mentioned that our report on EEG and behavioral mange:
in our thwapy resistant patients which was aunt to you my have
been misdimctod. I am taking the opportmity of submitting two
additional copies of the am Import for your maidemtion,
either for the mum lama: ad Pagcuamy or Pagehaphmcatagia.
Many thanks for your oonsiaamtion. Incidentally, I enjoyed
wading Sid Harlis' paper and have gone ahead and rammed a amber
of masked potmtials with a period of 1000 millisecond. Our moorda
are quite variable and mly occasionally seem to" much the samples
submitted in that Import. Hanover, his suggestion
to be

W

agoodommdmwilloontinuatooollwt additimal datain

this

dimontion.

Sinoemly yours,
Fink, NJ).
Professor of Psychiatry

Max

Mf'ﬁoh

�</text>
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                    <text>November 11 , 1965

Dr. Jmathm 0010

National Bank Building
6917 Arlington Road
Bathosda,

mum

Dar Jomﬁim:

mi: in to confirm our appointmt for mummy afternom,
Nombar 18, at 3:00 p.m. I will be ﬂying in ﬁrm St. Louis and
may arrive a few minutes late it tho plans are dolayod.

Wt,

I have mat with George and Mr. Warren 'I‘hompsm, missistam‘
Quiz-mm of the
md have tried to ostimata the
pmmatio needs of W113!!!) (EEG and 3mm
forthcmaindorofﬂxisyoar'a program. Ihavaankadthe
to amour in some mommﬂtions whid: I may be
able to disouss with you mgarding an orderly transition and the
funds from this grmt for oontinmd
possible transfer of
data analysis and write—up.
.

mimity

Psymoleogy)

m

Dr. Daub» has bean sending us the tapes on a

mgular basis

this analysis is progressing very well. However, it is
probably to our host immune to begin some of the analysas
duringﬁunmrtfowamths. Todoao, willmquimthatyou
and

pm.

mks available tom thaoode fort)» patiemrs in his
Withhisomoummoo, Imukingthatyouornr. Primmake
available to us the drug mount designations by patient
for the Manhattan State population in the sﬂizophrmia
am
project. We will not diaouss those with him but it will permit
us to malyu the data on the pratmahmt electmemophalogms

andtodatamim‘ ifﬁngmupamevmlymtdmdacoorﬂingto

than witoria.

Sincerely yours ,
Pink, NJ).
Professor of Psydxiatry

Hax

�</text>
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                    <text>November 26 , 1965

Dr. Jamthm Ooh

Natimal

Bank

Building

8917 Arlington Road

Bethesda, Maryland
Dcar Jmaﬂ'tm:

maimed is a

of the

list

of imitates for the

amt
VI forthccm.
Wmm
Wham.
the
replies.
earlier this math and we are organizing
I hope that

copy

we can have

next few make.

The

a definitive program within the
Sinoemly yours ,
Max

Fink, NJ).

Professor of Psymiatry

�</text>
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                    <text>December 1“, 1965

Dr.

Jomthm

Colo

National Bank Building
6917 Arlington Road
Bethesda, Maryland

Dsar Jomthm,
As I have
make an

discussed with you, Dr. Freedman has suggested
applicatim to the Health Research Council of
New York for support in the research pmgzwns
at the New York
Medical College. Wo have submitted an applicatim for a
Career Scientist Award. They have asked for letters of momma—-

that I

ticn and I

would be

grateful

if you, would

submit cm on

my

behalf.

The application form indicates that the letters of reference
”Should curtain a consulate appraisal of the applicants research

ability, originality, professional qualifications , personality,
letters should be submitted dimotly as
confidential oommioations to the Health Research Council of the
City of New York. ” The application also indicates that "If possible,
and moral character. The

of each letter of moomndatim would be appuoiaﬁsd.
bu most grateful for your efforts in answering tho

twonty copies

I

would

mquosts of the Health Rossarch Comcil.
Wv-rx':

"my thanks.
Sincerely yours ,

~MWWm-"4‘A'

Max

jay—”w"

,.

_

Fink,

11.1).

Professor of Psychiatry

"

�</text>
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                    <text>Jammy 3 ,

Dr.

Jmthm

Dr. Henry

National
591?

1966

001s and

Brill

Bank

Building

Arlingtm

Road

Batman, Marylmd

Duerathm and Henry,
The

Hallucimgm" form
Swim on ”Anﬁdmlimrgia
Wisﬁnpmposalmida

CINPispmgusingwrymn

IhwejmtmttoMﬂp.bassdmﬂnmpmseswhishIhave

mind. mis.ofm,1spmvisimlmd1mm1t1ng

humuhfmmmdywadsﬂniﬂWW.
n1».

Pmofﬂupwdcipmtshmsxpmsod financial ands.
langohmhdiwtsdthsthowiubcintmthitedmatu

fwmmmimmdmmmswmfwﬁa

add1tiau1tmdaystay.
Dmasrﬁam'hasmqmstadsuppwtmdm. Vetdsauxmd

trawl.
Vojudmskyhmuhudfurmmistminmir
uritctomilipsuggssting
mWﬂunmmimIdid
mmmmnaqu.
W,1fywamsdvisemasto
mmhpmmmimmbmmdahmm
lutspdm,1muldbsmfu1.

'Hmldﬁimdatbaswzdttmmﬁhshasmspwmpmblm
MMMmtingwithmgmtoﬁntmthissmim
winbscnpmgm. Cmymploueunmmimsessimsm
bummwidsfarﬂxissmosim.
Hybestwislus

forﬁuNwa.
sinmmly yours ,
Mn Pink, FLU.

Professor of ﬂymiatty

“ﬁlm
m:

g Egﬁey
“uh-.3

�</text>
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                    <text>February 22, 1956

Bath-roan, Harylmd
Dear-

20qu

Jam:

Whamviaadpmwforﬁympmimﬂform
mmnmﬂa.
, Immﬂnpartialpmtswdllmd
slidopmjaatmtfchx2md31leﬁinchslldn
Ha
wouldlikctofonawmmuyhofpmmmtimMa
MWM”
?

Halookfcrwmtommgyminmahingtm.
simmly yours,
ﬂax Pixie. $4.9.

Professor of Psychiatry

ca:

DP. Bradley

�</text>
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                    <text>Mb 18,

1966

Dr. Jonathan Colo
i-Iaticmal Bank Building

Arlington Road
Bethesda. Marylmd
693.7

Door

Jomtham

data oolloctim plum of the EEG material of the
collaborative schizophrenia project is now compute. Hy
Dunbar has collected records during the
period
and at one, two, four and six mth periods. We lave
analymd all tho tapes we ham waived except for sight,
and those will be mleted within the next few days.
The

W

As. em

initial step,

we:

ooztpamd

the thme

thent

pumps in the pro-drug conditim. to see if the records
had any significant diffomncoo in EEG criteria. I am
pleased to tel}. you mat the sampling was quite good

for these criteria.
We

am
data

have won

of the

ma:

&gt;

‘

»

-

alum. to answer such questims as the

diffemm in m; patterns at

each of the time periods.

These malyseo am only am part of the study which
pzoiocted. It would be imoromt to discuss the
youpro

behavioral

oomlatiom if these are of interest to
When I dimmd this with Hy earlier
agreed to can yaw offioa, and paﬂxaps to

EEG

ycmr smdy group.

thin wok. he

awanga

forum discussion

during the

CIR?

meetings.

can be waged, or. if youmold like to have
Dr. Bomto visit us. either step mum be helpful.

this

I look forward to seeing

you

at tho

If

GIMP.

Shoomly youm,

Mfzjnh
co: Dr.

Professor of Paydziauy

Pom F.

Prion

�</text>
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                    <text>735-603:

April 2nd. 1973

HMS? ﬁnch”. xii-Do.
Chairman. Research Gawain”,
Vatarm multratmn Hospital.
Northpcu‘t, 13.2.

Dear Doctor Walter.

to treat apiata Madam:
of the principal therapeutic modalities
availabla to us - ”Wont maintenance am! meatie antagonists
(cyclawcina).
As you know. we have: begun

Mama with two

Methadone Manama requires the daily administration
of methadone. This is both an expansive procedure for the
patiant and for nanny, and man an additional apaeial risk
tint drug given far
days my M: 9016., lost, stolen.
or inadvertently be fatal to non-dependent aubgeata.

$.me

moat modiﬁcation of mathadona maintenance ha: been
the use of a longer acting opiate, lmathadyl. In my
laboratory in Her ram. we have been ramnaibla far am a!
the principal m1; Mel: has dmatratod that levmthadyl
in doses batman 70 and 100 as can be given three times a wok,
roa- it provides aroumwlarama for varied. in excess or 72 hours
(indeed, our parent experiment it tho aduiniatratian of 100 mg
twiaa weakly. and w are most satisfied with the unless).
I m mm»; to propose the transfer of patients who are now on
in our outwtiant mega-am, and who have Men stabilized
mum”
for We months a: long“. from lanthanum to lmthadyl. Under
praaaxm governmental regulations , this 1: faaaibla under IR!) 6590.
Ono

Ihava'boanadviaadhym. E. Gardnarortharoodandm
Ammunition that notiﬁcation that we are carrying out the
study at ﬁlm Vatm mmtmtion 303mm will be accepted
by him. and such natiﬁeatian has been tent as him an Marat: 29th.
Fer your records. I m use melanin; a ccpy of tha protooal
vhieh the original “M1” ware done; and copies or three
rapeﬂmhiah «scribe our mime. The ﬁrst amen in

m

W

JAMA May

appear

8. 1912: and

current

thlatria

for months.

"

ma

ascend 15 in pron, in JAM, and
vault-a and a amry report. for
Than-ariaswhich should swear within 1:124: and:
than

“thin thc nut eight

�g!

,

E

.z

sunny maker. um.

‘

mum
m- Hgtiond Institute of

'

mm

~2—

2114,

1973

of Znulphs—cca‘hylmthtdol (mun)

Mal

no available mm
South. and hue shady bum

Waited with our pursuant.
I mmomwﬂl alsobaploandtakmthnt the“
a.
cox-unto.

ma 1: uranium
«“1311st manhunt“
m
ﬂatten 136.9331: thmtuhm the antics far the annual
causation at IWWJ. 1n opiate mama. It. 1: our
he imlmd in this
duh tint we will
«hm.
VA

T:

»

'
'

3

Q...

imam

«mam

1: tantalum to porn“
I trust that this
our previous aubuiuion far the clinical
max-m of «ammonia! and ”Mac. A: vs are ready to

gamut“ to mad

m

uncut: m, I
amount; notification of thin
mm
convenience.
at
mlili'k
mm m
would

smartly

,1

”H

‘

4%

yours.

mum.x.n.
Profoum- at Paychn‘bry

�</text>
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                    <text>Huvenber

Janathnn

lhth,

1972

Cole, M.D.,
Cha1runn. Credential: Gounittoﬁ,
A.

A.C.H.P. 3'
Boston Btntg 80391111,

Boston,

mu.

02121:.

I

D91: Jonathan.

I take great pleasure in ooaondtng the nan1nation or

JoVHn Simeon, M.D

1111 v111 pond you

currieulum vitae.

I have

fur unuburahip in the 1.6. H.P. Turun
a letter at nan1nntton and tn updutod

known Dr. Einaon

tine:

1955. vhﬁn

b. Joined

1h. Missouri Institute of Psyeh1atry. “hen I moved to
Run York he Joined me there, 1nd I have been acquainted
with h1m and his wbrk thcae noven years.

1: a wall tra1nod phyiieiun. method1aal and
careful in his work, v1th an tutoreat in clinical paycho~
pharmacology. Bo carried out systematic studies 1n
Ba

Hiasouri and

ﬂew York, and

I found

h1a work exemplary

At one point 1n h1s cutout he beans: internatcd 1n
tho upoo1:1 prcblann of :dolunaunco and chtldren, tad
.duvvlcpad a study pragrua 1n.tha effects of pgychanct1vo
drug. 1n than. populnt1ons. no beo¢ne enthusisstic about

this effart.
‘

For_a variety 5! pornonul reasons, ho,returned to
uinee entiblishad a study unit at tho

8%. Lou1s and has

ulnsouri In1titnto of Payeh1atry. He knows the literttur.
wall 1nd I b.1107. his. and V111 aontinua, to eontr1butc1
te- clinictl payuhcphsrnaualoay

I rononnsnd h1- nnuborthip to the A.C.N.P.
ha will contr1bnte to the wasting.
'

nu

I boliova

Btuccroly yours,

that

nr/aa

rm.

um.

Prorhsnor of Plyahiutry

�</text>
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                    <text>Febnmry B, 1966

Dr. Jm’dmn 0. Cole
National Bank Building
6917 Arlington Road

Bothum, Hazylmd

Dar Jma‘man,

I

am

writing with regard to lib-11880,

"EEG

andHumm Psycho-

law, this program will emplate its fourth
phammlow."
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yearofstudyatStdmﬁsthisSeptewer. with
bothDrs. Itil and
status of all the pmjccts in this prom
be practicable,
will
Shapim. my oomﬂeors, to the extant that it
myofﬁndxtaoollectimportimsofﬁziapmmwiubemleted
by early owner. However. the data malyses will not be muted
As you

Mmpmvidcfumforﬁzispwtofthepmgrm,lhave formlated
mappiicationfcrfmdstomlatethispmm,butatﬂwﬂew¥ork

mepiasoftheﬁmt fewpagoaofthe
Wmllega.
applicatimumidxlhawe senttoAlFmeanmforl-dsappmvalmd

Dean. I rave asked that the application be
85.3mm of theand
request its emsidemtim at the June/July
sent directly to you
matings of the appmpriate madman.

12m

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mammhic mutual describing the tedmical experiences with
analysis of rm is now almst mute, Inquiring
digital
mly collation and the pmpmtim of a suitable cover. I will submit
ampywiﬂtinﬂumxtfewmks, mdifadditimaloopieamaybe
The

consideration, I will be glad to send it,
as copies of any other of our publications, for your midemtion.

helpful to the
as

tall

may thmks for your assistanm.
Sincerely
Max

yam,

Pink, 3.1).

Professor of Paydxiatry

Hf‘ﬁq:

please indicate the status cf tbs Keskimr-Itil report
W
poet card
in
Psydwpatmlogy Related to antitative
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                    <text>m

an, 1955
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Cole
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for yaw lettsr regarding Hi 08597431 and the
amditim or this ward. we will found the mud-«1:11am in your Jamar, and as additional
m appﬁntod to the Imtituta Staff, pump”. a sapamta
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\

.

Dre.

Brill, Engelhardt, Epst»-4, Hollister,

Kurland
Williams,
Clyde,
Bonato,
Ruskin,
Klerman,
éihrann,
e

n.

May

4,

1964

Dr. Jonathan 0. Cole
Puychopharnncology Service Center
Rsaaarch Grant: &amp; Fulluwships Branch
national Institute of mental Healﬁh
Bothaada, Maryland

neat Jonathan:
pra-print is sent to you for discussion at
the next Clinical Committee «acting on Mhy 1a”

The enclosed

Sincerely,
Fink,
m
Director
Hrljb
Enc.

"‘

2

MOD.

�</text>
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                    <text>a,

May

1961.

Dr. Jonathan 0. Cola

Paychcphnucotm larvica Cantu
launch «rants &amp; Pullmhipc ”such
Hakim). Imam c! M“! malt!»
Dachau. nary!“ 2001‘
Dan

at.

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During tbs

Inchituhc
put In months. hethoprogram at thoa!Mum!
an
clinic“.
cnly
mum «calm

at Psychictry hm

0351‘! (nanny Rania-tact Psychosis
"mm
and In an”) . and
(Ant-mica ca anti-mounts“ Pacheco-—
in m paticnt
aim-tics) both an cunning tn study an
tbs and:
anti-bushing
Ictcna
an
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