http://exhibits.library.stonybrook.edu/mfp/files/original/5838c54aa085ca01e8292e9c1e12d904.pdf 9539e113cd5445d38827e57cc19579df PDF Text Text February 26, 1966 Dr. fiery A. B. Brazier Brain Research Institute University of Cslifornie st Los Angeles. Los Angeles, eelitornis Dear Dr. Bresier: In oorreoting the gslley proofs of the forthcoming bibliogrsphy of srticles on EEG ohenges with psychotropic oregs in men. Dr. Ajmone—Hsrseu suggested I may have omitted some to be fauna in your recent review in gligi§_l EnsEggoology gng Ihgz_ggg;1g;. Indeed. I did, end I so sdd1ng those which amplify the bibliogrsphy. noted e recurring note of apology - that little, oh, could be learned from studies in men! And. as you little. indicste. this is true. But. the envoi is charming - so charming. indeed, that I would like to quote it in its entirety in the At so first. I bibliogrsphy. It is true that the effects of these drugs are unolesrly defined; that the reports are contradictory (ss you indicate for reserpine end ioiprsoine); end that we leek theoreticel models for deserih~ in; the observed changes in the 336. not. could it not be that the lock of definition. the discrepancies. and even the leak of models are a reflection of the methoos end the sttitodes applied to the problems these pest few decades? By methods, I mesa the use of _dssoription rather than quentificetion; inadequate definition of population sod look of swereness of individusl differeooes of sub— jects; sud disregard of the pharmacological principles of dosage. route, rate and dorstion of drug administration. Too often. also. oethodologiesl limitations have interfered with enelysis, so is now true for the spplicstion of insensitive recording systems in electroencephslogrsphy ss spplied in sneethesiology; or the indiscriminate use of sedsting drugs in psychiatric services. �Dr. Kory A. 3. Erotic: 2-26~6& Page Two cttitodos, I rotor to the rnportc of drug affects at ”normal” reflecting a pathological modal rcthor than a physiological continuum of change in activity; and to the goncrnl By or "abnormal“. donigrction of studio: in man as being ”uncontrollod”, ”inclcgcnt". and "not.bcnic". Hapcfully, your rovicw and especially your cnvoi expresses an optimistic view thct may havc c salutary offcct. I have three spacific commontl. The rcforcnoc on pogo 103 to tho dcuynchronizing effects of cnticholincatcrcscs in anionic having "no The Wu mm. parallel in clinical electroencephalography"-ic inaccurcto. studies of. Rowntrcc 25 A}. (,1. Naomi... 5951 W £ayg§;a§”_;_: 47. 1950) demonstrated that DFP had a similar clcc~ trographic affect in can (while Grab 35.5; 4,. figsa. §;; 257, 1947, reported DFP electrical coiturorliko activity in man). ' ’ . By describing the cifccta of reserpine an "unlikely that the drug has any specifiic effect on the EEG, the signs of drowsiness being merely thooc secondary to the general rclcxction ..." (p. 104);. chlorpromazinc as "the appearance of normal drowsiness" (p. 105); and imiprcuinc as "... the effect on the alpha rhythm ... may merely be a nonsnccific indication of the degree of drowsiness" (p. $35); the specificity and individual differences of the electrOgraphic effects of those drugs are lost. Like description: of records as "normal" cnd "abnormal" which deny the possible significance of frequency and pattern changes. descriptions of a record as "drowsy" and "due to drowsiness" deny the possibility that there may be differences in the pattcrnn and imply a mechanism of action which may not be appropriate. ‘ it not truc that similar electrographic patterns may be soon in toxic stator, inflammatory conditiont, dogenorative disccsc cnd in 15 similarity of the graphic pattern nocoscatily roilocting the some pathophyoiology? Similarly, may it not be unproductive to doscribc the affect: of various drug: immature and aged normals, without the under the caption of "drowsinooc"? in a recent study using an clot“ tronic frequency analysis. we clearly separated the drug effects of chlorpromnzino and imipraninc, even though both compounds had many “nutrition 1: 36b. 1961). M. m. . Wm to the mochcnism of action of imipramino, it may not be known but the difference bctwccn imipraminc and MAO inhibition was exprcloa ad in the 1959. g: Spociol gum 52'12 Supplcncnt. At that contcrcncc. the anticholincrgic activity was cmphcciccd by 3133 (p. 879) and myself (9. 5169) ~ and that. saga gutionc have uincc boon confirmed by Coir-corona 35 g; Q. rigor?As 53% m. 9,: 224. 1953). � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Brazier, Mary A. B. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-1-172 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence