http://exhibits.library.stonybrook.edu/mfp/files/original/b0c2e2378bd6d9980c34f2d4d01e19dd.pdf 0a516aaddc1e8a6cabdfd8621c35fd53 PDF Text Text Ftbruary 5. Murray Bi 1964 Jlflik. ”In. Anteetatc Erofcnoor Bopartnnnt of Pharaacalozy Albert Eta-tutu Coll-g. of Mndietnn Yeshiva unlvurntty Enstchnltcr Bold New and Kerri; Park Arcnue Yark 61, New York Dan: Murray: Your quuatlons are the moat ligulflcant can: in tbs field of EEG and pharmacology, and I would be delightad if I could anawur than in a fashion which would havu cciuntiflc ligalflaanco. that tha fallovlng tutu!!! are a distillntc of my cxpcrlcnnt, tad the knovladso that an are activaly working on than. problnua. the following at. ch. annwaru a: b¢at I can gtvn than: With the flannxto: lv Puyehotraplc drugs such as iuipranlno. chlotpru-nstna. or nuptow btuata tnéuea chnnscn In tbs scalp ruuardQE 326 which are charaetcm— lltlc for the compound. The patturnn at: significantly altfctant on visual analysis and with treqnnncy analyst: equip-tat. (Raf. 1.2). Far group data. than. each psychotropic compound nouns ta have a characteristic spectra: of teaponln. tauponsal, hov¢V¢r. an éepand on the rate and route of ndnlalatru» tlou, Ina also on the prl~troatllnt canard pattora. W: at. new working on tbs problem of uhsthcr in an iadlvldual «:30, en; drug tanponsc can b. ldantlflad with eortnlnty. The associatn, Dr. 1:11. and I bellevu that with our present qututlttcation Inthod. a: eta diatingutnh in an individual subjuet «nah pnyehotropic agent and 31.0 taparatu diffetauetu bnacd on rate and deungn. Thu latter is new undo: study with pentothtl. chlarprannxlnn, tad dittnn. w. hiVu Itlidt.‘ that. taunt. bccaunc thay tupteuant diffarant classcs of drugu. fly blind ldcntlficatlon ho nodal” ... t tc-otrov, y... with on... ”Can today, with diffilaulty ... �Dr. Mntrsy E. Jsrvlk 2&5—6‘ Psgs Two (Psrsnthstlaslly, 1t hss has: my conviction that psychotrOpic drugs ssy hs tdsntlflsd nut only for that: clsss of sctlvlty, but for thstx :slstiss potency by stats EEG studlss. and I s: was in tbs sscand yssr at sash s study. (Est. 3]). 2. It is clssr that tbs EEG rssponss to s drug is dspsndsnt on ssny factors, chief of which are: drug, dose. tats, route. and prs~ trsstssnt tscsrd. Thsrs srs sons subjsats whats the psychological stats of tbs instvidssl may also contributs to lndlvléusl dlftsrsncs. so thst responslvlty to s drug ssy bs airfarsnt 1n schizophrsnlc, dsprssslvs. neurotic, sad psychopathlc subjsct. of Shsgsss, Goldman. Itll sud othsrs ladlcstss that ths rsspanse to s drug may have s tlssslflestory vslas. Thus. individual differencss may be both a limitstlon, if one is lutstsstsd in studying the effect of tbs dtug, or an sdvsntsgs 1f ens triss to The work EEG classify subject. I Tbs question as to whsthst alpha rhythm Being present or sbssat being s factor in drug response is not conclusive, since we hsvs lsstusd to describe s drug pattern in '10s slphs racords'. 'hlgh slphs *rseords‘, or 'slow wave records', with relative ease. 3. In my studies of convulslva therapy, I have come to tbs conclusion that indussd convulsians sre s device to chsngs the cholinstgtc» sntlchollnergic~chen1cal patterns of the brain. I have no tsspsct to: ths pure psychological explanation of EC? action. not do I bellsvs thst the pure electrOphysiologicsl models have any merit. ECT predatss systeustlc. definitive chemical changes in the central nervous systsu. and it is in response to these biochemlcil changes that the subject's behsviot is sltetsd. Thstsioro, drugs whleh'seam to opsrsta by altering tbs blochsnlcsl subu strsit of the brsln sad EC! sts hsslcslly the same machsuism. It is highly probsbls that s dung or cemblnstlen of drugs will be found thst hsvs tbs ssse blaths-ttsl psttsrns ss BOT. Iuéssd. s cosblustiaa llks ditrsn sufl ablatproussins produce EEG changes similar to ECT and as yns know, both drugs ssss to hsvs sn affect in depressive syndromes. thstspsntic sfflcscy 1s dissetly rslstsd t0 the degree sud typs of blow chsswssl ehsnss of the brain, and to that extent ECT and drug therapy sss very slsllsr. A. predict the sffscts of s drug in sdvsncs?” ... since we can't, we don't. "Csn us us would ... 1! vs could. fiosevsr. vs are working on this ptobleu. and I think the folluwtng ststsssnts ass trust gtvsn an ladlvtdusl pstlsnt in tbs £56 lsbotstory in when vs srs sbls to sdnlnlstsr ssrlstls 2 or 3 cospounds lutrsu venously to obssrvs the EEG psttsra chsnxs. us csn ssy tbs following: �Dr. Hurray E. Jarvlk 2~5w65 Pagu_Thru¢ It tho on chronic that. It. ctrtsln sonaral predlttlonn uhlth change. EEG cant. udulnlatratlan, it will thew n ndnlulttratloa. Dtpcudln; on tha type of Ihflfll u chtnga on EEG 31:11.: ahnnac far hthavlor. If tha tie: 336 to a than: tn lucrnaua tiara: fungi and 1n nyuchrnnlxatlon, a not. burtt nativity, it of nan be and: shift of £rcqu.n~ 1: likaly that lactonoad will fiauoantrata bchlvlotal change: Inflation; tranquilllaatlan, ward ptrtlelpstlon. tad Iona flattens: in tho expression of auxlaty. havtillty, tag. and irritability. thn subject If tho E86 show. lnarantud aynahronllttloa and introasud amounts of fast activity, it is likely that toelnllzation¢ group pnrtlclpntlon, activity level will increase. and anxltty. irritability will acetates. and general accrual. 1n :yuchroulxatlau. it in probable that lrrlttblllty. lllutary stnnatlonn, hallucinations. thought dlnordor sud anxiety will increase and withdrtval will become If the retard shown a prouinent. To the extent that that. bahtvioral environmental factor, observers diacasc has baen altarad. chlnga1 are maintained by will helluva that the subject's It hat bean a plantar; to answer your quantiona, and I an antlotlng a few refatcnccn whlch any tcflect my own View: in this area. I an 91333.4 that you are interacted. associate, Dr. ltll. tad I htva jalnad tegethar becansa HI have thc :01. of EEG in pnyuhlatry and allnlcnl pharmacology has bean gtossly undarcntilntod and ltrgely uaaxplared - I say My felt that this bananas I have on fly desk the gnlley praof of a bibliography antltled "EEG and Kazan Phamnacology”. conulatiag a: it does at 580 reference: tor the parted 1951—62. Detpito this largu number of studleu. chart at. only a fuw that hava paid attention to the probing: of individual diffutunens in tubjtctt, rate and rant. and 605.33 at ting. and the fine points of EEG analysis. It in tragic thit most of tho artltlcn dotl with such simplc conetptl at ”normal - abnormal”, and dtny the fact that thnro may be dlflcruatcs in the prcwtroatnnnt rueord which tffctt tha drug rcsponsu. Lest you tool that the nnlnnl pharmacologlata and nuu:0physlalog£sts have done better. let me ranlnd you that 45:91:. such toehnlqucs tn dcpth recording, cvaked potontltls. tad inglautcd cluetrodca, alnpla date rcnponne canvas. Iranian diffcrunttu, and indlvldanl variability in cal-ml; but. been largtly dltrcatrdod. �Dr. Hurray E. Jurvtk 2*5-6‘ Page Four It has baan u plan-urn to chat with you in look foruntd to wanting yon and dintutning here or £3 new York. this way, and I would this in pctuon, either Beat parsonal rcgardc. Pink, Dtrcntor Mn: 141/1!» Rue. 14.13. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. 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Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-1-111 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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