http://exhibits.library.stonybrook.edu/mfp/files/original/be352af0695a50f68579c97f48acccfd.pdf 9948852030ab9e12f46c02f5001edbc2 PDF Text Text rabrunry 5. 196‘ Murray 8. Jurvik. M.B. Aaseciate Professor at ‘ Pharmacology Albnrt Einltaln College of Mbdlclao Dcparzacnt thhiva Univntstty Eaatchttter Road and Mbrria Park Avenue Rev York 61, Rev York Dan: Hurray: Your quostions are the must significant onus in the field of EEG and pharmacology, and I «bald be delighted if I could answer than.1n g fashion which would hlVe scientific significance. with chm demurrer thtt the follnving answers avg a diatillatc of my axpcrtcnnu. and the knowlcdga that an nra activaly working on that: problems, the following are the answers at beat I can givu.thaa3 Psychotrapic drugs :uch an tnlprtuiuc.;chlarpramazlna, or lepro~ binaca induce chanscn in the aaalp recorded EEG which at: chnrlatcrintic for the compuund. The pattern: are tignificantly different an vtnunl analysis and with frequenuy analyula aquipaant. (Raf. 1.2). Fur group data. than, each paychctrupic compound seems to'havn a charactertttle updatruu of resgonse. 1v tatpanacn, howcvor. do anyond on the rate Ann tautc uf adulatatraw clan, and also on the pro~trontuont record pattern. we are new working on thn problan of whaehcr in an individual aase, the drug rasponso can Thu be ldcntlflcd with corttlnty. alloclnca. Dr. 1:11. 3nd I believe that with «at prcsent quaat££1~ cation method, we eta diatlnguiah in an indivléual subject caeh psychotr¢p1c agent and also scpnratc diffarunatn baoad an rate and dou‘sn. Th. lactct 1: now «nan: ttuéy with pantethnl. chlorpronazine, and ditrnn. Wu hava salactcd than: agontc bccauac thoy represent diffcxun: clnsncs of $russ~ My t blind identification be to-otrav, yna, with cast. “Can mada?” ... toény. with difficulty ... �Dr. Hurray E. 2w5—66 Jtrvik Pug: Tho (Parcnthatltally, it has bean av convictian that psychatttpic Grass may be identttlcd not only for that: class of aattvtty, but far chair tnlntivu potancy by taut: EEG studios. anfi I in now in tho nacond yant of such a study. tact. 3]). 2. It to clan: that the EEG ratponac to a drug is ficptndout on many flutters, thiaf of which at.: arug. data. rate, manta. and pra~ tr-atuont record. Thqra arc tau. nubjaata thta the psychologieal stat: of th; individual may alto canttihuta to Indiviéunl diffictaacc. no that tcaponulvtty to a drug may bu different in achitophranic; duprectiva. naurotit. and payehopsthtc tubjcet. The work of shagasc, Goldman. 1:11 and «that: indtentnl Chit ch; EEG-response to a drug may hnvc a claaaifieatoty wtlua. That. Individual differencas any he bath a limitation. if on: it Intcrustud in studying the Ittoct at tha drug, at tn ndvuntuzu I! out trim: to clauulfy subject. quootton as to whgthnr alpha rhythm Being ytosent or cbntut being a factor in drug response is net conclusivn, stun: nu hava Ioatnad to ficlctiho a drug pattarn in 'low alpha tacotda' ’high alpha reearda’. or ‘slow wtva rtcorda', with ralntiva 0‘86. Tha . In my studies at uonvalotva therapy, I haw: cane tn the aouclnsioa that Indutud tonvnlotan: are a dcvita ta chats. tha thalinotgicw anttehaliuntgic—chouical pattern: of the brain. I htvt no ratpcct for th: porn psychological unplannttoa a! BC! aetionb an: do I b¢11¢?u that the para olcettophyaiological nodal: have any atria. new predates syutennttt, daflnittvc cheudtal chtngel in tha tonttnl notvou: syutsa. and it It 1a teaponaa to than: biothanltil chunsau that tha tubjcct't 3. behavior 10 altared. Thetufote, drug. which seem to opatata by altering tho biothgnieal cnbw strait of the brain and EC? are hatiaally tha cane ”chant-m.~ It 1: highly probable that a drug at combinatten of drugs ‘11! be found thtt hgvg thc Iona btoahcuieal patttrnn as 361. Indead, a conklnatian like ditrnn and thlotpronaaine produec EEG changes 31:11am ta EC! and as you knew, both drugs seem to have an affect in daptoaaIV¢ syndrunet. Therapeutic efficacy is direttly relntad to the degraa and type of bio~ chemical chang. at the brain, and ta that datunt EC! and firms thttayy are very similar. 4. “Ctn u: predict tha effects of a drug In advance?" no unuld ... tine: we can't, it don't. ... if we could. on this ptohlcm, tad I think tbs falloutng trans givan tn Individual patina: in tn: EEG laboratory at. In whom wt It. nbln to administer IctiatIu 2 or 3 aonpaunds Inttuw venously to observe the EEG pattarn «hangs, in tan any tha fallowtna: Nunavut, in are working utntaunntl �Dr. Hurray E. Jarvik 2-5~6£ rtgu Theta t about a «hang. on Atutt adminlatratien. it will that changc on thtonlc administration. Dapcndins an thn typc of changn. that: at: certain sonatal ptadlctiont which can b: undo If thc EEG tinilat EEG far behavior. If ch. 886 than: tn intransa in tynthronitntlnn. a shift of frtqutau ties to a :lount rang: and can. karat activity. it is likely thtt the tubjaat will danoantrnta hchtvlaral changes of incrcatad nadatlan. trtuquilliattion. ward yarticipntion. tna taut doctoasn in the expretsion of anxiaty, hostility. tag. Ind itrlttbillty. If the EEG show: increased synchronization and inatetcnd amounts of fast activity. it is likely that lotitlixution‘ grasp participatlon. and general activity level will increase. and anxiety. irrltdhility will decraasc. a dtcroala ln synchronisation. it in probable that irritability, illutory tauaationn, halluciuntinns, thnught disorder and anxiety will increase and withdrawal will baton» If tha‘tecord than: prominent. To the extent that these behavioral changes are maintained by will believe that the tubjatt'a environmental factor, obtarvetu disuse: has been altered. It hat btan am a pleasure to answer your questions. and I am enclosing awn views in this area. I rcfctances which may reflect my pleased that you are interested. a few and I Itil, EEG of in role have jalaea tosathor butansc no have psychiatry and clinical pharaacology felt that thc been has grosnly undetcttinnted and largely unexplorud ~ I say bacsuna I haw: on.ng dank the sallay proof of I bibliography this "EEG and fiuman Pharmacology", conlllting as it dot: of entitlad 580 reference: for the patina l951~62. My astoclatc, Dr. ’ Despite this large number of studies. that. It. anly : {an that haw» pald attantion to th: problens of individual diffttcntas in subjects. rate and rant. and doing. of drug, 1nd the fine point: of EEG :nnlyais. It is tragic that most of tht urticltt deal with inch simpla conccptn a: “normal - nbnorual“, tnd dony the fact that that: may be fliffarcnccs in the prtotteatmant retard which affect the drug responsa. Lest yen final that tbs animal pharmacologltts and neurophysiologllts have done better. 1:: me rcaind yea that doapite such techniques as depth retarding, «voted potentials, and inglanted electrodon. oinpla flout rasponsc turret. IPQC1BG dlffercntau, and individual variability in animals hsvu been laragly disrugardoé. �Dr. Hurray E. Jarvth 2-5-6‘ Page Four It has been a pleasure to chat with you in chit way, and I would look forward to hunting yau and disculutng this in parse», oithar hut. or in New York. Bast poruanal regards, ”I! Fink, ntrcctor Mrljb Em: o H153. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. 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Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-018-1-109 Date A point or period of time associated with an event in the lifecycle of the resource 1964 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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