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                  <text>l...“

I

3%

Protocol for Pilot Project. on Effect
of Drug on Corebrsl Emotion
‘

1. Object:
(a)
(b)

on
of dmgn

To

study the effect

To

observe the emotional responses to such ohangca

and

the perception of sensory stimuli;

in function.

first drug

selected is LSD-25 (Sandoa) - on erect preparation
which, in very minute doses, produces a time state with altered perceptions,
emotional reactions and occasionally hallucinatory phenomena.
Studies or
porcep’onol change-s in the visual, amnion", an! anaesthetic senses are planned.
Special enmhasis is to be placed on the more complex functions of spatial and
temporal orientation; discrimination of size and shape; body may; and the
perooption of multiple Simmons stimuli
.111.

(1)
(2)
(3)

(h)

In the emotional aphoro, the following questions are oonsidorud:
Are the emotional responses secondary to or simultanemm with the
perceptual changes?
Are the “spams: consistent in repeated exporinonta in each
In each class of oubjoabo?
subject?
Are the emotional moponooa related to personality structure in
Hal?
any predictable fashion?
In there any relation of the mouse to drug aotim and tho
ability of the subject to utilize the mohanisn of denial?

In addition, there are thornpoutio oonoidorations:
Dona 131) have org arrest on depressions?
fl;
2 Does 15]) have am- valun in eliciting pmhiatrio material in
bloom,- impressed subjects?

2. Subjects:

(a)

‘

The subjects are in
"Normal” controln~

at

three groups:
hospital yeraomol or hospitalized patients

a general hospital.

(b) Psychiatric subjects at Hillside

Hog)

(1 Depression a» psychotic anti
(2 Scbimphronin
(3 N9W1Co

ital:

“satin.

(o) Neurological subjects at Mt. Sinai Hospital:
(1) Cerebral (119%,me or diffuse.

cord
disease.
Spinal
£2)
3) Spinal root disease.

30

W05!

subject is to be heated in a similar fashion prior to drug
ingestion) during the period of drug activity; and after. Subjects
Each

tmatodhyESTandinsulinmtoboexanimddmingaxﬂaﬁortho

Repeated sessions with each subject
course of such treatments
As the drug action has a duration 0: 2 to 5 hours,
arc planned.
The testing new be divided
testing proceduren my be extensive.

into three mops:
Neurologcal.
a)
gb Modical.

c)

tholoacal.
‘\

�3a.. Neurological:

1. Routine neurological.-

2"

Visual.
Perception of color mixed and ambiguous figures taohistoscopi celly
exposed; and cation ion or relative size and distance.
.

,

‘

3. Tactile.
he

Double simultaneous stimulation or various

Amt”.
Perception

modalities.

of latrines” identification of sounds and estimation

of time intervals.
5. Special studies of bochr image.
Bbo

Medical:
Observation of the subjects by members of the Department of Medicine
has been ”quested (Dr. A. Blmberg) and is under consideration.
BiocheMcsl studios of hormonal studios secondary to drug activity
is under consideration, with emphasis on the possible role of
adrenal function in the reactions as measured to the pattern of
wxﬂtosteroid excretion.

3c. Psycholouoalt

Clinical psychological testing is considered an integral port 0
The cooperation of Dr. M. Ger-vita has been rethis survw.
An evaluation 0:: personality structure and habitual
quested,
methods of reaction to stress will be studied in each subject.
In addition, special testing procedures to study the mechanism
of denial are under stuck ha a. member of the psycholomstafrz:,-;LC
(lire Antinoph).

Specific testing procedures include the following tests:
a Rorschach.
b Bender Gestalt.
c
d

TvoTl
Special tests for denial.

he Supplies, Foods, Eton:
The drugs have been made available to me for experimental purposes;
Funds for the
at no charge kw Sundae Pharmaceutical Company.
equipmt moesssry for testing have been placed at my disposal
by the Neurological Research Fund of the Mt. Sinai Hospital.
The

following items are requested from Hillside Hospital:
(1) Office space and the use of one room in Treatment Dormitory
during experimental days.
(2) Availability of records and permission to request occasional
coowration of Homing Department and of the Record Room

staff.

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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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