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�Richard Weiner

FROM:

FOR RELEASE

FINN INCORPORATED
13u.East 59 Street

RUDER &amp;

MAX

York 22, New York
PLaza 9-1800

New

FOR:

7, 1958

HILLSIDE HOSPITAL

A

Island psychiatrist whose research points to the underlying

Long

changes necessary to reverse the depressive type of mental
honored

this

Dr.

week by

Max

be

Fink, Director of the Department of Experimental Psychiatry

at Hillside Hospital,
A. E.

illness will
a major national psychiatric association.
Glen Oaks (Queens),

New

York,

will receive the first

Bennett Neuropsychiatric Research Foundation Award. The Society of

fé

Biological Psychiatry will present the award at the group's 13th Annual
Meeting in San Francisco, California, on May 11.

The meeting

is part of

:
'1‘

the American Psychiatric Association Annual Meeting.
Dr. Fink will present a paper on his work

Cholinergic Agent, Diethazine, on

EEG

titled, "Effect of Anti-

and Behavior:

Significance for

Theory of Convulsive Therapy."
The

report describes experimental studies of the neurophysiologic

for "shock" therapies. Dr. Fink and his associates
at Hillside Hospital have observed that changes inla specific enzyme

and biochemical bases

system of the brain, acetylcholine-cholinesterase, are intimately

to improvement in electroshock.

However, changes

related

in the opposite direction

are accompanied by hallucinations, delusions, and psychotic behavior.

that decrease the activity of the acetylcholine normally present,
in the brain excite psychotic activity. They also reverse the electroshock
Drugs

effect.

Some

of the newer hallucinogens, such as lysergic acid

(LSD) and

,

�-2mescaline, are most potent in this regard.

halts the hallucinogenic action of these
shock effect.
The

On

the other hand, chlorpromazine

compounds and enhances

Hillside research extends the understanding of the

the electro-

mode

of action

of convulsive therapies by defining the biochemical bases for the observed

neurophysiologic effects.
The

studies have been supported by the National Institute of Mental

Health and the Board of Directors' Research Fund of Hillside Hospital.
Dr. Fink is Secretary of the Section of Convulsive Disorders and

Brain Function of the American Psychiatric Association and President-

Elect of the Nassau Neuropsychiatric Society.

Hillside Hospital, an affiliate of the Federation of Jewish

is a non—profit, non-sectarian hospital
for psychiatric treatment, training and research.

Philanthropies of

New

York,

####

�_

»‘.&gt;\7"»

&gt;v.—

'—

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16

Peace Missionary May
;’Have to Pacify “Family
'

i

i

.

'

i

Mrs. Lola Stone, pretty young Long Island. housewife
who’s on an interna—
tional peace mission to ban nuclear
tests, may have some pacifying to do when she
gets home.
The husband and two children of the globe-trotting
proud of her campaign, but they miss her and Wish she’d 'peace missionary are
hurry home to Kanes
Lane, Huntington Bay.
,

.TA Reiecis

1

"‘We think she’s wonderful,
we’re quite proud of her, but it
urts some time,” her husband,
Robert, said with a smile.
‘We’re counting the days.”
Mrs. Stone is one of a group
of five pacifists on a 4,000-

Protest

mile tour of European capitals
‘

By MBA

‘

They have been stalled in
Helsinki for a week because
of the reluctance cf the Soviet
Union to grant them entry
The Transit Authority today
visas.
brushed aside a Motorman’s
“We are hoping the visas
Benevolent Association protest
will come through,” Mrs. Stone
that it would be “dangerous”
told her husband by phone
for‘ motormen to leave their
from Helsinki. “The most imcontrols on the EMT Myrtle,
portant part of our mission
Avenue line to help operate the
lies ahead. We hope this is
doors.
just a routine delay.”
“The MBA is making a DR. MAXIMILLIAN
FINK
The group flew from Idlemountain out of a molehill,” a
wild April 14, and stopped at
TA spokesman said.
London, Paris, Bonn and West
Theodore Loos of Jamaica,
Berlin to interview national
the association’s president, proleaders and “just plain people.”
tested yesterday that a train’s
Despite a brush-off "at 10
brakes might slip -— and the
Downing St., official residence
train start rolling—while the
of British Brime Minister Harmotorman was out of his cab.
old Macmillan, the overall re“Under our order,” the Tranaction was “favorable and opsit Authority spokesman said,
timistic,” Mrs. Stone reported.
“the motormen will have to
l.The scheduled last lap of the
leave his cab only under cerjourney was to be Russia,
tain conditions . . . and those A Long Island
psychiatrist where the group hoped to perconditions Only crop up once will
receive the first A. E. Ben- suade Kremlin officials to
in a blue moon.
Even if the motorman leaves nett Neuropsychiatric Re- agree to an unconditional ban
on nuclear testing as “a demhis controls, he’ll never be search Foundation Award.
more than four feet from the He is Dr. Ma'ximillian Fink onstration of their sincerity.”
Expenses of the trip are
brake.”
of 13- Bayview Ave., Great being borne by “Non Violent
The TA said its order applied only to a few stations on Neck, director of experimental Action Against Nuclear Weapthe Myrtle Avenue line. At psychiatry at Hillside Hospital, ons,” the same group that
sponsored the voyage of the
those stations, there’s no Glen Oaks.
“Golden Rule,” stopped
change collector at night, so Dr. Fink ‘will receive the ketch,
the conductor on the train col- award. Sunday from the Soci- by the Coast Guard off Hawaii.
lects fares. The motorman will ety of Biological Psychiatry at
be asked to help the conductor its annual convention in San
Fishermen Angry
out when a “big crowd” boards Francisco.
the train.
Over Empty Pond
He is being honored for re“We only pick up an aver- search- into the
effect of HARTFORD, Conn. (UP)—
age of four persons per trip at “shock”
Red-faced officials of the State
all those stations put together,” “we’vetherapy.
been able to discover Fish and Game Department
the TA spokesman said. “We
the mentally ill respond admitted somebody
goofed
.
.
almost never get a crowd how
to shock therapy,” Dr. Fink when angry fishermen
pomt')
\ ' there."
explained. “And, just as im- ed out in a department-proportant, we’ve learned why vided pamphlet that Day Pond
some persons do not respond in Colchester was stocked with
”at
trout and open for fishing.
to such treatments.”
j t'Dr.’ Fink has livedtin Long The anglers had risen before
I
Island since 1950, and was ap- daWn! ion:- opening day and
made thetrip to the Mind,
'
r
3

_

'

‘

'

Psychiai‘risfs

Will Honor
L. Docfor

_

_

giteconsider

'11:,

,

Q

.

.

’

.

U

�1/15/59
Department of Egperimental Psychiatry
and
the
of
presentations
a
chronologic
Following is
list
of
members
Experimental
the
of
Department
of
the
publications
Psychiatry during 1958.

M
Publications:

A.

1.

Changes in Language During Electroshock Therapy, in
of Communication, Hoch, P. and Zubin,
Ps cho atholo
3. eds., Grune E Stratton, (Kaﬁn, R.L. and Fink, M.)

2.

Lateral

3.

h.
5.
6.

Gaze Nystagmus as an Index of Sedation Threshold,

Clin. Neurophysiol. l9: 162-163 (Fink, M.).
Effect of Diethazine on EEG and Significance h for Theory
8101. 19:
of Convulsive Therapy, EEG. Clin. Neuro
207-208 (abst.) (Fink, H.5.
Experimental Studies of the E1ectroshock Process, Dis.
Nerv. Syst. l2: 113-118 (Fink, M. and Kahn, R.L.).
Comparative Study of Chlorpromazine and Insulin Coma
18h6-1850
166:
J.A.M.A.
of
Psychosis,
Therapy
(Fink, M., Shaw, R., Gross, G. and Coleman, F.C.).
Eleotroencephalographic Correlates of the ElectroshockM.
227
(Abst.) (Fink,
Nerv.
Dis.
Syst.
12:
Process,
EEG.

and Green,

7.

8.

9.
10.

l1.

R.,.

Language of the Dyad, Psychiatry El: 2h9-258 (Jaffe, J.).
Clinical and EEG. Effects of Megimide in Patients without
M.
682-685
(Green,
Cerebral Disease, Neurology g:
and Pink, M.)

Effect of Anticholinergic Agent, Diethazine,
&amp;

on EEG and

Psych. ﬁg: 380-388,
Behavior, A.M.A. Arch. Neurol.
(Fink, M.).
Experimental Studies of Convulsive and Drug Therapies on
A.M.A.
Arch.
Theoretical
Implications,
Psychiatry:
Neurol. &amp; Ps ch. 80: 733-73h (Abst.) (FinE, R., Kahn,
R.E. and Green, M77.
Brain Damage, Mental Retardation and Childhood Schizophrenia,

12.

Oculomotor and Postural Patterns in Schizophrenic Children,
A.M.A. Arch. Neurol. &amp; Ps chiat.‘12: 720-726
(Pollack, M. and Krieger, H.P.5.

13.

A.M.A.
Arch.
of
Denial
in
Factors
Illness,
Interpersonal&amp;
Ps chiat. ﬁg: 653-656 (Jaffe, J. and
Neurol.
SiBtEj'W.H.).

�1h.

B.

Predictions of Outcome, in Youthful Offenders at
Hi hfields, Weeks, H. Ashley, e3. U. of
Michigan P ress, Ann Arbor (N. Siegel).

Presentations:
EEG Correlates of the Electroshock Process, at the
1.
Eastern Psychiatric Research Association, February,
M.
N.Y. (Fink,

3.

and Green, M.A.).

EEG
Changes
in
of
Individual Variability
Significance
During Electroshock Therapy, at Eastern Association
of Electroencephalographers, March, Montreal,
(Green, M.A.).
and
Drug Therapies
Convulsive
of
Studies
Experimental

in Psychiatry: Theoretical Implications, at
New
York Society of
and
Society
Neurological
Clinical Psychiatry, March, N.Y. (Fink, M., Kahn,
R.L. and Green, M.A.).

Abnormal
and
Normal
in
and
Attention
Visual Perception
’Children, at American Orthopsychiatric Association,
March, N.Y. (Pollack, M.).

Patterns with Altered Brain Function, at
Eastern Psychological Association, April,
and
M.).
R.L.
Fink,
Kahn,
(Jaffe,
Philadelphia
J.,
and
F
Behavioral
Physiological
Score
to
of
Relation
Response with Altered Brain Function, at Eastern
Psychological Association, April, Philadelphia,

Communication
The

(Kahn, R.L. and Fink, M.)

7.

Intellectual Deficits in Patients with

Space Occupying

Lesions of the Cerebrum, at Eastern Psychological
Association, April, Philadelphia (Pollack, M.,
Battersby, W.S., Kahn, R.L. and Bender, M.B.).
Simultaneous
of
and
of
Perception
Stimulation
Intensity
Stimuli in Cerebral Dysfunction, at Eastern Psychological Association, April, Philadelphia (Korin, H.).

�-3-

10.

Socio-Psychological Aspects of Diagnosis and Treatment:
Theoretical Implications, Symposium - Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Pollack, M.).
Drug Induced Changes in Interview Patterns, at
Conference on Psychodynamic, Psychoanalytic, and
Sociologic Aspects of the Neuroleptic (tranquilizing)
Drugs in Psychiatry, April, Montreal (Fink, M.
and

All.
12.

16.
17.

18.

19.

Psychological Factors Affecting Individual Differences
in Behavioral ResPonse to Convulsive Therapy, at
American Psychiatric Association, May, San
Francisco (Fink, M., Kahn, R.L. and Pollack, M.).
Prognostic Value of Rorschach Criteria in Clinical
Response to Convulsive Therapy, at Electroshock
Research Association, May, San Francisco (Kahn, R.L.
and Fink, M.).
Effects of Anticholinergic Agent, Diethazine, on EEG
and Behavior: Significance for Theory of Convulsive
Therapy, at Society of Biological Psychiatry, May,
San Francisco (Fink, M.).
Social Factors in Selection of Therapy in a Voluntary
Mental Hospital, at American Psychiatric Association,
May, San Francisco (Kahn, R.L. and Pollack, M.)
A Critique of "Pre-Conscious" Perception and the
"Poetzl Phenomenon," at American Psychiatric
Association, May, San Francisco (Pollack, M.).
Role of EEG Frequency Shift in Behavioral Effects of
Drugs, at Section on Neurol. &amp; Psychiat. Queens.
County Medical Society, June, N.Y. (Fink, M.).
Effect of Anticholinergic Compounds on Post Convulsive
EEG and Behavior, American EEG Society, June,
Atlantic City (Fink, M.).
EEG and Behavioral Effects of Psychopharmacologic Agents,
at Collegium Internationale Neuro-Psycho Pharmacologicum, September, Rome, and Eastern Association of
Electroencephalographers, December, N.Y. (Fink, M.).
Prognostic Application of Psychological Techniques in
Convulsive Therapy, at Eastern Psychiatric Research
Association, October, N.Y. (Kahn, R.L. and Pollack,
M.).

20.

Jaffe, J.).

'

Relationship between Seizure Threshold and Duration of
Seizures to EEG Change During Electroshock, at
IEastern Association of Electroencephalographers,
December, New York (M.Green).

�uuucav twain; by»: anuunsu

.lmost as well as if he
:ould see. Here he climbs
the schdol steps with his

ypewriter to attend ‘ a
class.

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MD Records
Brain Waves
Of Patients
,

A history written in brain

waves is telling the story
today 01' how successfully
the mentally ill are responding to electro-shock and

drug treatments.
Dr. Max. Fink, a Great
Neck psychiatrist who gave
up a proﬁtable private practice to “prospect for Iacts”,»~
has developed a method of
evaluating the brain waves
of patients at Hillside Hospital, Glen Oaks,_ where he’s
been leading an eight--man
research team for four
years.
The brain wave "history”,
recorded on graph paper
and transmitted by an. electroencephalogram, enables
the hospital's staff to “treat
patients with more direction” Fink says.
It works this way:
The encephalogram picks
up brain waves of a new
patient and records a “base
line” on the graph.
As the patient is treatedand repeatedly tested the
variations are recorded on
the graph. Comparisions
show whether a patient is
. or isn’t . . . responding
to a drug or shock treatment.
,

l

f

,

1

;
I
1

1

l
K

1

‘

.

-

-

3|!

1|:

1‘

“THE STUDY gives a
new and keener sense of
direction in treating the
patients,” Fink said.
For example: If a patient’s brain wave “history”
shows that his response to
is suddenly

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�February 25, 1959.
Department of Experimental Paychiatry
Annual Report

-

1958

During 1958, the major emphasis of the

staff of the

Department of

Experimental Paychiatry shifted from evaluation of convulsive therapy to

systematic investigations of newer psychopharmacologic agents. These

investigations, derived from the successful evaluations of the

mode

of action

of convulsive therapy (l95h-l958), reserpine (1955), and chlorpromazine and

insulin

coma

(1956-1957), are based on the neurophysiologic-adaptive hypothesis

of physiodynamic therapies developed in the Department in 1957
ﬂggg. é? 197-206).

the

The

many new compounds

(J. Hillside

interrelationship of the neurophysiologic effects of

with the psychodynamic, perceptual, personality and

sociologic aSpects of patients' behavior provide the framework for these

investigations. In addition, linguistic indices developed in the Department
during the past two years by Drs. Kahn and Jaffe are being studied as measures

both of behavioral change and of neurophysiologic effect.
During the year, the evaluation of convulsive therapies was continued

effects of indoklon, an inhalant convulsant, with electroconvulsive therapy. 'This study was undertaken by two senior resident

by comparing the

psychiatrists,

B. Alan and H. Lefkowits, and Drs. Green and Fink.

While

indoklon therapy was a successful treatment, technicallimitations made
poor substitute for the established

electrical

methods.

The

it a

study was of

theoretic value in indicating that the significant element of convulsive
therapy was the induction of the grand mal convulsion, with

its attendant

neurophysiologic effects, independent of the type of agent employed.

�V

,

.2Investigations into the relations of sociologic factors to the

selection of therapies at Hillside Hospital were extended by Drs.

Kahn and

Pollack. Not only were the factors of age, education, birthplace, and score
on the California F Scale significantly related to the choice of therapy but
these factors were also related to the results of therapy, the diagnosis and
the duration of hOSpitalization. These observations were presented in the
Sunday Conference of October 16, 1958.
and

On

October

7

the study was repeated;

similar studies of the population of other primarily psychotherapeutic

hospitals,

and the Hillside Hospital Out-Fatient Department were undertaken.

To augment

these studies, Dr. Nathaniel Siegel was appointed as Research

Associate in Sociology, with the support of a grant from the Mental Health
Board of Nassau County.

In an extension of the communication studies, both the syntactic
content analysis and dyadic diversification measures of formal aSpects of
speech were applied to an evaluation of the changes in language patterns

following the acute administration of various new psychotropic compounds.
These measures demonstrated

and the neurophysiologic
The

consistent changes both with the induced behavioral

effects of the drugs.

acute drug interviews were but one asPect of the continuing

evaluation of the biochemistry of convulsive therapy. Previous studies had
indicated that repeated induced convulsions resulted in an increased level
of central nervous system acetylcholine activity.

€g¥:;;;;:;;;;:§
of various
anticholinergic
stages of convulsive therapy

we

compounds

By

the acute administration

to patients at various

elucidated the synaptic chemical events

which are the basis of the convulsive therapy process.

�-3In addition,

Mr. Karp and Drs. Kahn and

Pbllack continued their

perceptual studies in patients receiving psychodynamic therapies. The interrelation of psychotherapy with physiodynamic therapy was studied by Drs.
Esecover, Jaffe and Kahn; and in the
and H. Lefkowits began an

latter part

of the year, Drs. A. Kaplan

investigation into the interpersonal factors in

therapists, as well as patients, leading to the referral for physiodynannc
therapies.
During the year, Dr. H. Korin resigned, and was replaced by Mr. Eric
Karp.

TWO

new

staff

appointments include Dr. Nathaniel Siegel, Assistant

Professor of Sociology at Columbia University, as Research Associate in
Sociology; and Dr. Donald Klein, research

candidate at the

New

York Psychoanalytic

scientist at
Institute, as

Creedmoor

Institute

Research Associate in

Psychiatry.
Support for this extensive program was provided by the Board of

Directors, and continuing grants of the Foundations'

Fund

for Research in

Psychiatry and the National Institute of Mental Health. At year end, this
program received considerable Support from the Psychopharmacology Service
Center of the National

Institute of

Mental Health, which augmented

extensive commitment by a grant of $268,000. These

its

already

further

sums were

increased during the year by support from the Mental Health Board of Nassau
County which provided funds

Smith, Kline

&amp;

for sociologic studies;

and from

Bristol, Geigy,

French, and wyeth Laboratories ~ who aided the drug evaluation

program by grants as well as extensive supplies of the agents

During the year, fourteen reports of the work of

staff

to

be

studied.

members

appeared; and twenty reports were presented to major professional societies.

�-hIn addition to national societies, work of the Department was presented at
the Conference on Psychodynamic, Psychoanalytic and Sociologic Aspects of
Neuroleptic Drugs in Montreal, and the International Congress of Neuropsychopharmcology in Rome.

Staff

first

members were awarded two

prizes. Dr.

M.

Fink received the

annual A.E. Bennett Peychiatric Essearch Award of the Society of Biologic

Psychiatry for his report on the effects of anticholinergic agents on

EEG

and

behavior. Dr. J. Jaffe received the Gralnick Foundation annual award for his

report

on the

application of analysis of changes in fonnal aSpects of Speech

in psychotherapy.

�-5The

staff

of the Department of Experimental Psychiatry included,

at

year end:
MEX

Fink, M.D.

Direeees

Joseph Jeffe, M.D.

Research Associate (Peychiatry)

Donald F. Klein,

Research Associate (Peychiatry)

MQD.

Robert L. Kahn, Fh.D.
Max

Pollack,

Pth.

Research Associate
(Experimental Psychology)
Research Associate
(Experimental Paychology)

Nathaniel Siegel, Ph.D.

Research Associate (Sociology)

Eric Karp, B.A.

Research Assistant
(Experimental Peychology)

Martin A. Green, M.D.

Associate in Research

Abraham A. Kaplan, M.D.

Associate in Research (Paychiatry)

Barre Alan, M.D.

Fellow (1957-58)

Henry Lefkewits, M.D.

Fellow (1958-59)

The

(Neurophysiology)

technical staff included Mrs. Janet Bowie, Jean Kolodny,

Mbsquera and Blanche

Hannah

Zaitz.

addendum: In February Dr. George Krauthamer, Ph.D. was appointed

as Research Assistant (Experimental Psychology).

electroencephalography.

He

is a trainee in

�nan-{u

£55,

1959.

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�1/15/59
Department of Experimental Psychiatrz

list

and
the
of
presentations
a
chronologic
Following is
of
Experimental
members
of
the
Department
of
the
publications

Psychiatry during 1958.
A.“ Publications:
1.
Changes in Language During Electroshock Therapy, in
of Communication, Hoch, P. and Zubin,
Ps cho atholo
3. e38., Urune E Stratton, (Kaﬁn, R.L. and Pink, M.)
of Sedation Threshold,
2.
Lateral Gaze Nystagmus as an Index162-163
(Fink, M.).
EEG. Clin. Neurophysiol. lg:
EEG
and Significance for Theory
on
of
Diethazine
3.
Effect
of Convulsive Therapy, EEG. Clin. Neurophzsiol. l9:
207‘208 (abate) (Fink,
Process, his.
h.
Experimental Studies of the Electroshock
M.
and
Kahn,
R.L.).
113-118
(Fink,
Nerv.
l2:
Coma
and
Insulin
of
Chlorpromazine
5.
Comparative Study
18h6-1850
166:
J.A.M.A.
of
Psychosis,
Therapy
G.
and
Coleman, F.C.).
Shaw,
Gross,
M.,
R.,
(Fink,
6.
Electroencephalographic Correlates of the ElectroshockM.
S
Nerv.
Dis.
st. $2: 227 (Abst.) (Fink,
Process,
o

o

stt.

and Green, H.$.

7.
8.

9.
10.

(Jaffe, J.).
Pszchiatrz 3;:
Effects of Megimide in Patients without
M.

Language of the Dyed,

Clinical and

EEG.

2h9-258

Cerebral Disease, Neurologz Q: 682-685 (Green,
and Fink, M.)
EEG
and
on
Diethazine,
Agent,
of
Anticholinergic
Effect
&amp; Pszch. ﬁg: 380-388,
Arch.
Neurol.
L.M.A.
Behavior,
(Fink, M.).
on
and
Drug
Therapies
Convulsive
of
Studies
Experimental
Arch.
A.M.A.
Theoretical
Implications,
Psychiatry:
Neurol. &amp; Ps ch. 80: 733-73h (Abst.) (FInE, 3.. Kahn,

F.I.

and Green, M77.

ll.

Brain Damage, Mental Retardation and Childhood Schizophrenia,
Am. J. Pszchiat. 115: h22-h28 (Pollack, M.).

12.

Oculomotor and Postural Patterns in Schizophrenic Children,
A.M.A. Arch. Neurol. &amp; Ps chiat..12: 720-726
(Pollack, M. and Krieger, H.P.5.

13.

Arch.
A.M.A.
of
Denial
in
Factors
Illness,
Interpersonal&amp;
Ps chiat. ﬁg; 653-656 (Jaffe, . and
Neurol.

Slate,

W.H.$.

�1’40

B.

Predictions of Outcome, in Youthful Offenders at
Hi hfields, Weeks, H. Ashley, e3. U. of
Michigan P ress, Ann Arbor (N. Siegel .

Presentations:
1. EEG Correlates of the Electroshock Process, at the
Eastern Psychiatric Research Association, February,
N.Y. (Fink,

M.

and Green, M.A.).

2.

EEG
Changes
in
of
Individual Variability
Significance
During Electroshock Therapy, at Eastern Association
of Electroencephalographers, March, Montreal,
(Green, M.A.).

3.

and
Drug Therapies
Convulsive
of
Studies
Experimental
in Psychiatry: Theoretical Implications, at
New
York Society of
and
Society
Neurological
Clinical Psychiatry, March, N.Y. (Fink, M., Kahn,

R.L. and Green, M.A.).

Abnormal
and
Normal
and
in
Attention
Visual Perception
Children, at American Orthopsychiatric Association,
March, N.Y. (Pollack, M.).

Patterns with Altered Brain Function, at
Eastern Psychological Association, April,
and
M.).
R.L.
Fink,
Kahn,
Philadelphia (Jaffe, J.,
Relation of F Score to Behavioral and Physiological
Response with Altered Brain Function, at Eastern
Psychological Association, April, Philadelphia,

Communication

6.

The

(Kahn, R.L. and Fink, M.)

7.

Intellectual Deficits in Patients with Space Occupying
Lesions of the Cerebrum, at Eastern Psychological

Association, April, Philadelphia (Pollack, M.,
Battersby, W.S., Kahn, R.L. and Bender, M.B.).
Simultaneous
of
and
Stimulation
Perception
of
Intensity
Stimuli in Cerebral Dysfunction, at Eastern Psychological Association, April, Philadelphia (Korin, H.).

�-3-

10;

Socio-Psychological Aspects of Diagnosis and Treatment:
Theoretical Implications, Symposium - Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Pollack, M.).
Drug Induced Changes in Interview Patterns, at
Conference on Psychodynamic, Psychoanalytic, and
Sociologic ASpects of the Neuroleptic (tranquilizing)
M.
Montreal
(Fink,
Drugs in Psychiatry, April,
and

11.

12.

13.

16.
17.
18.

19.

Jaffe, J.).

Psychological Factors Affecting Individual Differences
in Behavioral Reaponse to Convulsive Therapy, at
American Psychiatric Association, May, San
Francisco (Fink, M., Kahn, R.L. and Pollack, M.).
Prognostic Value of Rorschach Criteria in Clinical
Response to Convulsive Therapy, at Electroshock
Research Association, May, San Francisco (Kahn, R.L.
and Fink, M.).
EEG
on
Diethazine,
of
Agent,
Anticholinergic
Effects
and Behavior: Significance for Theory of Convulsive
Therapy, at Society of Biological Psychiatry, May,
San Francisco (Fink, M.).
Social Factors in Selection of Therapy in a Voluntary
Mental Hospital, at American Psychiatric Association,
May, San Francisco (Kahn, R.L. and Pollack, M.)
A Critique of "Pre-Conscious" Perception and the
"Poetzl Phenomenon," at American Psychiatric
Association, May, San Francisco (Pollack, M.).
Role of EEG Frequency Shift in Behavioral Effects of
&amp;
Neurol.
on
Section
Psychiat. Queens
Drugs, at
County Medical Society, June, N.Y. (Fink, M.).
on Post Convulsive
Effect of Anticholinergic Compounds
EEG and Behavior, American EEG Society, June,
Atlantic City (Fink, M.).
EEG and Behavioral Effects of Psychopharmacologic Agents,
at Collegium Internationale Neuro-Psycho Pharmacologicum, September, Rome, and Eastern Association of
Electroencephalographers, December, N.Y. (Fink, M.).
Prognostic Application of Psychological Techniques in
Convulsive Therapy, at Eastern Psychiatric Research
Association, October, N.Y. (Kahn, R.L. and Pollack,
M.).

20.

Relationship between Seizure Threshold and Duration of
Seizures to EEG Change During Electroshock, at
Eastern Association of Electroencephalographers,
December, New York (M.Green).

�law
HILLSIDE HOSPITAL

Glen Oaks,

New

York

March 16, 1959

MEMO TO RESEARCH

FROM:

RE:

'

COWITI'EE

JOSEPH S.A. MILLER, M.D., MEDICAL DIRECTOR
ATTACHED RESEARCH REPORT

I

herewith enclosing copy of Dr.
sending it a few days in advance of the meeting,
familiarize yourself with some of the main facts
position to discuss this when it is presented at
meeting on March 25th.
am

Fink's report,

so that you might
and be in a better

the forthcoming

�FebmaIy 25, 19590
Department of Experimental Peychiatry
Annual Report

-

1958

During 1958, the major emphasis of the

staff of the

Department of

Experimental Paychiatry shifted from evaluation of convulsive therapy to

systematic investigations of newer psychopharmacologic agents. These

investigations, derived from the successful evaluations of the

mode

of action

of convulsive therapy (l9Sh-l958), reserpine (1955), and chlorpromazine and

insulin

coma

(1956-1957), are based on the neurophysiologic-adaptive hypothesis

of physiodynamic therapies developed in the Department in 1957
Eggg.

the

ﬁg

197-206).

The

many new compounds

(J. Hillside

interrelationship of the neurophysiologic effects of

with the psychodynamic, perceptual, personality and

sociologic aspects of patients' behavior provide the framework for these

investigations. In addition, linguistic indices developed in the Department
during the past two years by Drs. Kahn and Jaffe are being studied as measures
both of behavioral change and of neurophysiologic effect.
During the year, the evaluation of convulsive therapies was continued
by comparing the

effects of indoklon, an inhalant convulsant, with electro-

convulsive therapy. This study was undertaken by two senior resident

psychiatrists,

B. Alan and H. Lefkowits, and Dre. Green and Fink.

'While

indoklon therapy was a successful treatment, technicallimitations made

it a

poor substitute for the established

electrical methods. The study was of
theoretic value in indicating that the significant element of convulsive

therapy was the induction of the grand mal convulsion, with

its attendant

neurophysiologic effects, independent of the type of agent employed.

�.2the
to
factors
of
the
sociologic
relations
into
Investigations
Kahn
and
Drs.
extended
by
were
Hillside
Hospital
of
at
selection
therapies

Pollack. Not only were the factors of age, education, birthplace, and score
on the California F Scale significantly related to the choice of therapy but
and
the
of
diagnosis
the
to
results
therapy,
related
also
these factors were
the duration of heapitalization. These observations were presented in the
Sunday Conference of October 16, 1958.
and

On

October

7

the study was repeated;

similar studies of the population of other primarily psychotherapeutic

undertaken.
were
Out-Patient
Department
and
HOSpital
Hillside
the
hoSpitals,
To augment

these studies, Dr. Nathaniel Siegel was appointed as Research

Associate in Sociology, with the support of a grant from the mental Health
Board of Nassau County.

In an extension of the communication studies, both the syntactic
content analysis and dyadic diversification measures of formal aspects of
epeech were applied to an evaluation of the changes in language patterns

following the acute administration of various new psychotropic compounds.
These measures demonstrated consistent changes both with the induced behavioral
and the neurophysiologic
The

effects of the drugs.

acute drug interviews were but one aspect of the continuing

evaluation of the biochemistry of convulsive therapy. Previous studies had
indicated that repeated induced convulsions resulted in an increased level
of central nervous system acetylcholine activity. By the acute administration
of various tertiary-amine anticholinergic compounds to patients at various

stages of convulsive therapy

we

elucidated the synaptic chemical events

which are the basis of the convulsive therapy process.

�-3In addition, Mr. Karp and Drs.

Kahn and

Pbllack continued their

perceptual studies in patients receiving psychodynamic therapies.

inter-

The

relation of psychotherapy with physiodynamic therapy was studied by Drs.
Esecover, Jaffe and Kahn; and in the latter part of the year, Drs. A. Kaplan
and H. Lefkowits began an

investigation into the interpersonal factors in

therapists, as well as patients, leading to the referral for physicdynamic
therapies.
During the year, Dr. H. Korin resigned, and was replaced by Mr. Eric
Karp.

TWO

new

staff

appointments include Dr. Nathaniel Siegel, Assistant

Professor of Sociology at Columbia University, as Research Associate in
Sociology; and Dr. Donald Klein, research

candidate

at the

New

York Psychoanalytic

scientist at
Institute, as

Creedmoor

Institute

Research Associate in

Psychiatry.
Support for this extensive program was provided by the Board of

Directors, and continuing grants of the Foundations'

Fund

for

Research in

Psychiatry and the National Institute of Mental Health. At year end, this
program received considerable support from the Psychopharmacclogy Service
Center of the National

Institute of

Mental Health, which augmented

extensive commitment by a grant of $268,000. These

its

already

further

sums were

increased during the year by support from the Mental Health Board of Nassau
County which provided funds

Smith, Kline

&amp;

for sociologic studies;

French, and wyeth Laboratories

- who

and from

Bristol, Geigy,

aided the drug evaluation

program by grants as well as extensive supplies of the agents

During the year, fourteen reports of the work of

staff

to

be

studied.

members

appeared; and twenty reports were presented to major professional societies.

�.1...

In addition to national societies, work of the Department was presented at
the Conference on Psychodynamic, Psychoanalytic and Sociologic Aspects of

Neuroleptic Drugs in Montreal, and the International Congress of Neuropsyohophamacology in Rome.

Staff

first

members were awarded two

prizes. Dr.

M.

Fink received the

annual A.E. Bennett Paychiatzic Research Award of the Society of Biologic

Psychiatry for his report

on the

effects of anticholinergic agents

on Em and

behavior. Dr. J. Jaffe received the Gralnick Foundation annual award for his

report

on the

application of analysis of changes in formal aspects of Speech

in psychotherapy.

�-5The

staff

of the Department of Experimental Psychiatry included,

year end:
Max

Fink, M.D.

M

Joseph Jaffe, MlD.

Research Associate (Peychiatry)

Donald F. Klein,

Research Associate (Psychiatry)

MgD.

Robert L. Kahn, Ph.D.

Research Associate
(Experimental Peychology)

Pollack, Ph.D.

Research Associate
(Experimental Psychology)

Max

Nathaniel Siegel, Ph.D.

Research Associate (Sociology)

Eric Karp, B.A.

Research Assistant
(Experimental Psychology)

Martin A. Green, M.D.

Associate in Research

Abraham.A. Kaplan, M.D.

Associate in Research (Paychiatry)

Barre Alan, M.D.

Fellow (1957-58)

Henry Lefkowits, M.D.

Fellow (1958-59)

The

(Neurophysiology)

technical staff included Mrs. Janet Bowie, Jean Kolodny,

Mosquera and Blanche
Addendum:

Hannah

Zaitz.

In February Dr. George Krauthamer, Ph.D. was appointed

as Research Assistant (Experimental Psychology).

electroencephalography.

at

He

is a trainee in

�1/15/59
Department of Experimental Psychiatry
and
the
of
presentations
a
chronologic list
Following is
of
members
Experimental
the
of
Department
of
the
publications
Psychiatry during 1958.

Publications:

A.

1.

Changes in Language During Electroshock Therapy, in
of Communication, Hoch, P. and Zubin,
Ps chopatholo
3. eds., Grune &amp; Stratton, (Kahn, R.L. and Fink, M.)

2.

Lateral

3.

h.
5.
6.

Gaze Nystagmus as an Index of Sedation Threshold,

Clin. Neurophysiol. 19: 162-163 (Fink, M.).
EEG
and Significance for Theory
on
of
Diethazine
Effect
of Convulsive Therapy, EEG. Clin. Neurophysiol. 19:
EEG.

Experimental Studies of the Electroshock Process, Dis.
M.
and Kahn, R.L.).
113-118
(Fink,
Nerv. Syst. 12:
Coma
and
Insulin
of
Chlorpromazine
Study
Comparative
Therapy of Psychosis, J.A.M.A. 166: 18h6-1850
G.
and
Coleman, F.C.).
Shaw,
Gross,
R.,
(Fink, M.,
Electroencephalographic Correlates of the ElectroshockM.
Process, Dis. Nerv. Syst. 12: 227 (Abst.) (Fink,
and GreenTWMTfT—___-—*—

(Jaffe, J.).

7.

Language of the Dyad, Psychiatry 31: 2h9-258

8.

without
Patients
in
of
Megimide
Effects
Clinical
M.
682-685
(Green,
Q:
Cerebral Disease, Neurology
and EEG.

and Fink, M.)

9.
10.

on EEG and

Effect of Anticholinergic Agent, Diethazine,
&amp; Psych. g9: 380-388,
Neurol.
A.M.A.
Arch.
Behavior,
(Fink, M.).
on
and
Drug
Therapies
Convulsive
of
Studies
Experimental
A.M.A.
Arch.
Theoretical
Implications,
Psychiatry:
Kahn,
M.,
&amp;
(FinE,
80:
733-73h
(Abst.)
Neurol.
Psych.
R.E. and Green, M77.

11.

Brain Damage, Mental Retardation and Childhood Schizophrenia,
Am. J. Psychiat. 115: h22-h28 (Pollack, M.).

12.

Oculomotor and Postural Patterns in Schizophrenic Children,
A.M.A. Arch. Neurol. &amp; Ps chiat. 12: 720-726
(Pollack, M. and Krieger, H.P.5.

13.

A.M.A.
Arch.
of
Denial
in
Factors
Illness,
Interpersonal&amp;
and
653-656
J.
Ps
(Jaffe,
ﬁg:
Neurol.
chiat.
Slote, W.H.§.

�1h.

B.

Predictions of Outcome, in Youthful Offenders at
H. Ashley, ed. 5. of
Highfields, Weeks,
Michigan Press, Ann Arbor (N. Siegel).

Presentations:
the
EEG
at
Electroshock
of
the
Process,
Correlates
l.
Eastern Psychiatric Research Association, February,
M.
N.Y. (Fink,

and Green, M.A.).

EEG
Changes
in
of
Individual
Variability
Significance
During Electroshock Therapy, at Eastern Association
of Electroencephalographers, March, Montreal,
(Green, M.A.).

Experimental Studies of Convulsive and Drug Therapies
in Psychiatry: Theoretical Implications, at
New
York Society of
and
Society
Neurological
Clinical Psychiatry, March, N.Y. (Fink, M., Kahn,
R.L. and Green, M.A.).
Visual Perception and Attention in Normal and Abnormal
Children, at American Orthopsychiatric Association,
March, N.Y. (Pollack, M.).
Communication Patterns with Altered Brain Function, at
Eastern Psychological Association, April,
and
M.).
R.L.
Fink,
Kahn,
(Jaffe,
Philadelphia
J.,

Relation of F Score to Behavioral and Physiological
Response with Altered Brain Function, at Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Fink, M.)
Intellectual Deficits in Patients with Space Occupying
Lesions of the Cerebrum, at Eastern Psychological
Association, April, Philadelphia (Pollack, M.,
Battersby, W.S., Kahn, R.L. and Bender, M.B.).
Simultaneous
of
and
of
Stimulation
Perception
Intensity
Stimuli in Cerebral Dysfunction, at Eastern Psychol~
ogical Association, April, Philadelphia (Korin, H.).

The

�-3-

10.

Socio-Psychological Aspects of Diagnosis and Treatment:
Theoretical Implications, Symposium - Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Pollack, M.).
Drug Induced Changes in Interview Patterns, at
Conference on Psychodynamic, Psychoanalytic, and
Sociologic Aspects of the Neuroleptic (tranquilizing)
M.
Montreal
(Fink,
Drugs in Psychiatry, April,
_

and

11.

12.

13.

16.
17.
18.

19.

Jaffe, J.).

Psychological Factors Affecting Individual Differences
in Behavioral Response to Convulsive Therapy, at
American Psychiatric Association, May, San
Francisco (Fink, M., Kahn, R.L. and Pollack, M.).
Prognostic Value of Rorschach Criteria in Clinical
Response to Convulsive Therapy, at Electroshock
Research Association, May, San Francisco (Kahn, R.L.
and Fink, M.).
EEG
on
of
Agent,
Diethazine,
Effects
Anticholinergic
and Behavior: Significance for Theory of Convulsive
Therapy, at Society of Biological Psychiatry, May,
San Francisco (Fink, M.).
Social Factors in Selection of Therapy in a Voluntary
Mental Hospital, at American Psychiatric Association,
May, San Francisco (Kahn, R.L. and Pollack, M.)
A Critique of "Pre-Conscious" Perception and the
"Poetzl Phenomenon," at American Psychiatric
Association, May, San Francisco (Pollack, M.).
Role of EEG Frequency Shift in Behavioral Effects of
&amp;
Neurol.
on
Section
Psychiat. Queens
Drugs, at
County Medical Society, June, N.Y. (Fink, M.).
on Post Convulsive
Effect of Anticholinergic Compounds
EEG and Behavior, American EEG Society, June,
Atlantic City (Fink, M.).
EEG and Behavioral Effects of Psychopharmacologic Agents,
at Collegium Internationale Neuro-Psycho Pharmacologicum, September, Rome, and Eastern Association of
Electroencephalographers, December, N.Y. (Fink, M.).
Prognostic Application of Psychological Techniques in
Convulsive Therapy, at Eastern Psychiatric Research
Association, October, N.Y. (Kahn, R.L. and Pollack,
M.).

20.

Relationship between Seizure Threshold and Duration of
Seizures to EEG Change During Electroshock, at
Eastern Association of Electroencephalographers,
December,

New

York (M.Green).

�1/15/59
Department of Experimental Psychiatry
and
the
of
presentations
Following is a chronologic list
of
Experimental
the
members
Department
of
the
of
publications
Psychiatry during 1958.
A.

Publications:
in
Therapy,
Electroshock
During
Language
Changes in
1.
and
Zubin,
P.
Hoch,
Communication,
of
cho
Ps
atholo
3. eds., Grune &amp; Stratton, (Kaﬁn, R.L. and Fink, M.)
of Sedation Threshold,
2.
Lateral Gaze Nystagmus as an Index162-163
(Fink, M.).
EEG. Clin. Neurophysiol. 19:
EEG
and Significance for Theory
on
of
Diethazine
3.
Effect
of Convulsive Therapy, EEG. Clin. Neurophysiol. 19:
h.
5.
6.
7.

8.
9.
10.

11.
12.

13.

Process, Dis.
Experimental Studies of the Electroshock
M.
and Kahn, R.L.).
113-118
(Fink,
Nerv. Syst. 12:
Coma
and
Insulin
Comparative Study of Chlorpromazine
18h6-1850
166:
J.A.M.A.
of
Psychosis,
Therapy
and
G.
Coleman, F.C.).
Shaw,
Gross,
R.,
(Fink, M.,
Electroencephalographic Correlates of the ElectroshockM.
227
(Fink,
(Abst.)
Nerv.
Dis.
Syst.
12:
Process,
and Green, M.,.
2h9~258
21:
(Jaffe, J.).
the
Dyad, Psychiatry
Language of
without
in
Patients
of
EEG.
Megimide
and
Effects
Clinical
M.
682-685
(Green,
Cerebral Disease, Neurology g:
and Fink, M.)
EEG
and
on
Diethazine,
Agent,
Effect of Anticholinergic
&amp; Psych. ﬁg: 380-388,
Neurol.
Arch.
A.M.A.
Behavior,
(Fink, M.).
on
and
Drug
Therapies
Convulsive
of
Studies
Experimental
Arch.
A.M.A.
Implications,
Theoretical
Psychiatry:
(FEEET'MTT’Kahn,
733—73h
&amp;
80:
(Abst.)
Ps
ch.
Neurol.
ﬁ.f. and Green, M77.
Brain Damage, Mental Retardation and Childhood Schizophrenia,
Am. J. Psychiat. 115: h22—h28 (Pollack, M.).

W..—

Oculomotor and Postural Patterns in Schizophrenic Children,
A.M.A. Arch. Neurol. &amp; Ps chiat..12: 720-726
,fPollack, M. and Krieger, H.P.5.
Arch.
A.M.A.
of
Denial
in
Illness,
Interpersonal&amp; Factors
Ps chiat. ﬁg: 653-656 (Jaffe, J. and
Neurol.
Slote, W.H.$.

�1h.

B.

Predictions of Outcome, in Youthful Offenders at
Hi hfields, Weeks, H. Ashley, ed. U. of
Michigan Press, Ann Arbor (N. Siegel).

Presentations:
EEG Correlates of the Electroshock Process, at the
1.
Eastern Psychiatric Research Association, February,
M.
N.Y. (Fink,

and Green, M.A.).

EEG
Changes
in
of
Individual Variability
Significance
During Electroshock Therapy, at Eastern Association
of Electroencephalographers, March, Montreal,
(Green, M.A.).

and
Drug Therapies
of
Convulsive
Studies
Experimental
in Psychiatry: Theoretical Implications, at
New
York Society of
and
Society
Neurological
Clinical Psychiatry, March, N.Y. (Fink, M., Kahn,

R.L. and Green, M.A.).

Abnormal
and
Normal
and
in
Attention
Visual Perception
Children, at American Orthopsychiatric Association,
March, N.Y. (Pollack, M.).

Patterns with Altered Brain Function, at
Eastern Psychological Association, April,
and
M.).
R.L.
Fink,
Kahn,
(Jaffe,
Philadelphia
J.,
Relation of F Score to Behavioral and Physiological
Response with Altered Brain Function, at Eastern
Psychological Association, April, Philadelphia,

Communication
The

(Kahn, R.L. and Fink, M.)

Intellectual Deficits in Patients with

Space Occupying

Lesions of the Cerebrum, at Eastern Psychological
Association, April, Philadelphia (Pollack, M.,
Battersby, W.S., Kahn, R.L. and Bender, M.B.).
Simultaneous
of
and
of
Stimulation
Perception
Intensity
Stimuli in Cerebral Dysfunction, at Eastern Psychological Association, April, Philadelphia (Korin, H.).

�-3Socio—Psychological ASpects of Diagnosis and Treatment:

10.

Drug

Theoretical Implications, Symposium - Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Pollack, M.).
Induced Changes in Interview Patterns, at
Conference on Psychodynamic, Psychoanalytic, and
Sociologic ASpects of the Neuroleptic (tranquilizing)
M.
Montreal
(Fink,
Drugs in Psychiatry, April,
‘

and

11.

12.

16.
17.
18.

19.

Jaffe, J.).

Psychological Factors Affecting Individual Differences
in Behavioral Reaponse to Convulsive Therapy, at
American Psychiatric Association, May, San
Francisco (Fink, M., Kahn, R.L. and Pollack, M.).
Prognostic Value of Rorschach Criteria in Clinical
Response to Convulsive Therapy, at Electroshock
Research Association, May, San Francisco (Kahn, R.L.
and Fink, M.).
EEG
on
of
Agent,
Diethazine,
Effects
Anticholinergic
and Behavior: Significance for Theory of Convulsive
Therapy, at Society of Biological Psychiatry, May,
San Francisco (Fink, M.).
Social Factors in Selection of Therapy in a Voluntary
Mental Hospital, at American Psychiatric Association,
May, San Francisco (Kahn, R.L. and Pollack, M.)
A Critique of "Pre-Conscious" Perception and the
"Poetzl Phenomenon," at American Psychiatric
Association, May, San Francisco (Pollack, M.).
Role of EEG Frequency Shift in Behavioral Effects of
&amp;
Neurol.
on
Section
Psychiat. Queens
Drugs, at
County Medical Society, June, N.Y. (Fink, M.).
Effect of Anticholinergic Compounds on Post Convulsive
EEG and Behavior, American EEG Society, June,
Atlantic City (Fink, M.).
EEG and Behavioral Effects of Psychopharmacologic Agents,
at Collegium Internationale Neuro-Psycho Pharmacologicum, September, Rome, and Eastern Association of
Electroencephalographers, December, N.Y. (Fink, M.).
Prognostic Application of Psychological Techniques in
Convulsive Therapy, at Eastern Psychiatric Research
Association, October, N.Y. (Kahn, R.L. and Pollack,
M.).

20.

Relationship between Seizure Threshold and Duration of
Seizures to ERG Change During Electroshock, at
Eastern Association of Electroencephalographers,
December, New York (M.Green).

�1/15/59
Department of Experimental Psychiatry
and
the
of
presentations
Following is a chronologic list
of
EXperimental
members
the
of
Department
of
the
publications
Psychiatry during 1958.

Publications:

A.

1.

Changes in Language During Electroshock Therapy, in
of Communication, Hoch, P. and Zubin,
Ps cho atholo
M.)
and
E
R.L.
(Kahn,
Fink,
Grune
Stratton,
J. eds.,

2.

Gaze Nystagmus as an Index of Sedation Threshold,

3.

h.
5.
6.
7.

8.
9.
10.

11.
12.
13.

Lateral

M.).
162-163
(Fink,
Clin. Neurophysiol. 19:
EEG
Theory
for
and
on
Significance
of
Diethazine
Effect
of Convulsive Therapy, EEG. Clin. Neurophysiol. lg:
EEG.

Process, Dis.
Experimental Studies of the Electroshock
Nerv. Syst. 12: 113-118 (Fink, M. and Kahn, R.L.).
Coma
and
Insulin
of
Chlorpromazine
Comparative Study
18b6-1850
166:
J.A.M.A.
of
Psychosis,
Therapy
and
G.
Coleman, F.C.).
Shaw,
R., Gross,
(Fink, M.,
Electroencephalographic Correlates of the ElectroshockM.
227
(Fink,
(Abst.)
Nerv.
Dis.
Syst.
12:
Process,
and Green, ﬁ.$.
2h9-258
(Jaffe, J.).
the
of
g1:
Dyed,
Psychiatry
Language
without
in
Patients
EEG.
Megimide
of
and
Effects
Clinical
M.
682~685
(Green,
Cerebral Disease, Neurology g:
and Fink, M.)
EEG
and
on
Diethazine,
Effect of Anticholinergic Agent, &amp;
380-388,
Q9:
Neurol.
Arch.
A.M.A.
Psych.
Behavior,
(Fink, M.).
on
and
Drug
Therapies
Convulsive
of
Studies
Experimental
Arch.
A.M.A.
Implications,
Theoretical
Psychiatry:
Kahn,
(Fink,
&amp;
ﬁ.,
80:
733-73h
(Abst.)
Ps
ch.
Neurol.
R.I. and Green, M77.
Childhood
and
Schizophrenia,
Mental
Retardation
Damage,
Brain
Am. J. Psychiat. 115: h22-h28 (Pollack, M.).
Oculomotor and Postural Patterns in Schizophrenic Children,
&amp;
Ps chiat._12: 720-726
Neurol.
Arch.
A.M.A.
(Pollack, M. and Krieger, H.P.5.
Arch.
A.M.A.
of
Denial
in
Illness,
Factors
Interpersonal&amp;
and
653-656
J.
Ps
(Jaffe,
chiat.
g9:
Neurol.
Slote, W.H.$.

�1h.

B.

at
Predictions of Outcome, in Youthful Offenders
U.
H.
of
Ashley,
ed.
Weeks,
Highfields,
ichigan Press, Ann Arbor (N. Siegel).

Presentations:
the
at
EEG
Electroshock
of
Process,
the
Correlates
1.
Eastern Psychiatric Research Association, February,
M.
N.Y.

2.

(Fink,

and Green, M.A.).

EEG
Changes
in
Significance of Individual Variability
During Electroshock Therapy, at Eastern Association
of Electroencephalographers, March, Montreal,

(Green, M.A.).

and
Drug Therapies
Convulsive
of
Studies
Experimental
in Psychiatry: TheoreticalNewImplications, at
York Society of
Neurological Society and
Clinical Psychiatry, March, N.Y. (Fink, M., Kahn,

R.L. and Green, M.A.).

Abnormal
and
Normal
and
in
Attention
Visual Perception
Children, at American OrthOpsychiatric Association,
March, N.Y. (Pollack, M.).

Patterns with Altered Brain Function, at
Eastern Psychological Association, April,
and
M.).
R.L.
Fink,
Kahn,
Philadelphia (Jaffe, J.,
and
F
Behavioral
Physiological
to
Score
of
Relation
Response with Altered Brain Function, at Eastern
Psychological Association, April, Philadelphia,

Communication
The

(Kahn, R.L. and Fink, M.)

7.

with Space Occupying
Intellectual Deficits in Patients Eastern
Psychological
Lesions of the Cerebrum, at

Association, April, Philadelphia (Pollack, M.,
Battersby, W.S., Kahn, R.L. and Bender, M.B.).
Simultaneous
of
and
of
Stimulation
Perception
Intensity
Stimuli in Cerebral Dysfunction, at Eastern Psychol—
ogical Association, April, Philadelphia (Korin, H.).

�-3-

10.

Socio-Psychological ASpects of Diagnosis and Treatment:
Theoretical Implications, Symposium - Eastern
Psychological Association, April, Philadelphia,
(Kahn, R.L. and Pollack, M.).
Drug Induced Changes in Interview Patterns, at
Conference on Psychodynamic, Psychoanalytic, and
Sociologic Aspects of the Neuroleptic (tranquilizing)
Drugs in Psychiatry, April, Montreal (Fink, M.
_

and

11.

12.

16.
17.

18.

19.

Jaffe, J.).

Psychological Factors Affecting Individual Differences
in Behavioral Response to Convulsive Therapy, at
American Psychiatric Association, May, San
Francisco (Fink, M., Kahn, R.L. and Pollack, M.).
Prognostic Value of Rorschach Criteria in Clinical
Response to Convulsive Therapy, at Electroshock
Research Association, May, San Francisco (Kahn, R.L.
and Fink, M.).
EEG
on
of
Agent,
Diethazine,
Effects
Anticholinergic
and Behavior: Significance for Theory of Convulsive
Therapy, at Society of Biological Psychiatry, May,
San Francisco (Fink, M.).
Social Factors in Selection of Therapy in a Voluntary
Mental Hospital, at American Psychiatric Association,
May, San Francisco (Kahn, R.L. and Pollack, M.)
A Critique of "Pre-Conscious" Perception and the
"Poetzl Phenomenon," at American Psychiatric
Association, May, San Francisco (Pollack, M.).
Role of EEG Frequency Shift in Behavioral Effects of
&amp;
on
Neural.
Section
Psychiat. Queens
Drugs, at
County Medical Society, June, N.Y. (Fink, M.).
Effect of Anticholinergic Compounds on Post Convulsive
EEG and Behavior, American EEG Society, June,
Atlantic City (Fink, M.).
EEG and Behavioral Effects of Psychopharmacologic Agents,
at Collegium Internationale Neuro-Psycho Pharmacologicum, September, Rome, and Eastern Association of
Electroencephalographers, December, N.Y. (Fink, M.).
Prognostic Application of Psychological Techniques in
Convulsive Therapy, at Eastern Psychiatric Research
Association, October, N.Y. (Kahn, R.L. and Pollack,
MI).

20.

Relationship between Seizure Threshold and Duration of
Seizures to EEG Change During Electroshock, at
Eastern Association of Electroencephalographers,
December, New York (M.Green).

�\\.\"

‘\

Soptubor 1,

1959

rm m2
mm

H.927

Dumb-at of mparimntal Psychiatry
HWPM
WEE
Glen
H.
L.

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1.

thmm

3.

3mm
8mm,

h.

Publications,

1951:

- 1959

5.

Presentations,

1951;

6.

Smnmry #1,

September 1.

- 1959
1951::
-

7.

Sunny #2,

Mary 1.

8.

Smmry #3,

April 1, 1957

2.

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February 1, 1959

Five Years, 199;

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1956 ~

January 1, 1956

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March Asaoomboa
EEG

1957

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Ha:

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1, 1959

1959

Principal Investigator
Research Associates

I.

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Psychology)

(Neurophysiology)

Technician

Secretuy

m,n.n.

Robert L. Kahn.Ph.Do
Hymn Karin, £11.13.

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Martin A.

momma.

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1956
Joseph Jaffe,M.D.
Donald F. K1o1n,24..n.
1959
Nathaniel 319301,Ph.D. 1958

«-

Georgo
Hanna Mosquera
Janet Baltic

Associates, supported throng: other grants:
Research Associate

Mouth

Associate
amorob Associate
Research Associate

(kperimntal Paydnol.)

( Psychiatry)

(Psychiatry)

(Sociolm)

Max

Pollackﬁhon.

.

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mnpy

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nonnspeciftc state of altered brain function, similar to omnioosrsbnl

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upliﬂed

(10, 11. 21). Within this altered

osrobn}. milieu, subjects were seen to respond in variom ways (26) ,
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lotto)? adsptation was most prominent in chamooerclogioﬂly disposed

indvidmls (36).
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listed in

�variety of beluvieml changes lure eeen during convulsive therapy
(26; 8-17). Such patterns were viewed as edepteticne to altered brain
A

Motion,

and were believed dependant upon

chencterologic end environ-

mental tactore (7, 25, 26, 36, ho). Clinical

retina: of

improvement

cbeemr or the behavioral change. in
the subject (26). Adaptations chmcterieed by denied www.mm
1n behavim' (13.17) and in language (7.
WM—
Such adaptations! were related to habitual node.

were new as value Judgments by the

W
or conduct (character,
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ML
(inability

per-MW)

BMW

(36; 3-11, 32).

of the altered behavioral nodes wee noted ee

dependant upon the degree and duration of

mm

alterec breln function. the

expectatlone, an! the type and degree of family and

medical support. Different behavioral patterns were beet supported by

WIt m eke

typee or psychothonpy (19)..

that the ’nemphwelolcglcel beele of
lie in on duration in central emptic

suggeeted

M?

commune therepy any
cholinerglc - cannot-31c relationship, with a predominant
to
incremd cholinergic activity as the operationally significant

wt

:3th.

illumination: were based on the nutimdllp of man voltage EEG
Olav wave activity to behavioral change (6, 11, 26) and the blocking at

Such

poet-mun

;

electmgrephic and behavioral changee by central

entichonnergic agents (21; 3h: 35;

bl.

1&amp;2)

and by centre].

unpethwmtic

agents (ha).

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(1h, 29 ;

13-21.)

creaeed denial,

interviews shoved characteristic alterations towards in-

minutiae,

displacement, stereotypy and repetitivemes,

related to the degree of altered brain function (8.214). These changes were
blocked or reversed by enticholinsrgic

mlucinogm (21.

ha) .

Various perceptual tasks provided indices of behavioral, change and

were related to the degree of altered brain function. These included the

perception of cinulteneoue tactile

figures (37; 3-16),
color tigorcs (1:1).

and

stimli

(17), embedded (Gottschsbdt)

techistoaoopioelly exposed words (37) and

embedded

upsets or age, years of education, nativity and
degree of stereotypy and conventionslity (measured by Column F Scale)
were related to selection of therapy, duration or hospitalisation, e
diegmeie and treetsent response in hospitalised patients (15, 36,. to, 1:5).
Sooiopsyohologic

2.

Nsmmmlogio—Adspuve mom-1e of Sonauc' Theron.
Based on these studies, a hypothesis of the node of action of other

psydxistx'ic therapies such as insulin coho, leucotoav and psychotropic
drugs, was expressed (10, 33, 38). This View holds that the efficacy of

these therapies depends upon the indiction of states of altered brain
The
become
which
prominent.
in
adoptive
varying
mttems
my
much,
adaptive pettem is releted to the type, degree end duration of altered

brain function, the personality of the subject, and tolersnoes end
expectaﬂons of the environmnt.

Elicitation of this Wthesis as applied to drug therapies is our

in progmss, supported

by uspm greats 111.2092 and 111-2715.

'

'

�3.

Eula

Gena

Thong.

in iniﬂal case

yettem

e'mdy showed the significance both or denial

and peraieten’e

in insulin

coma

altered brain function for the behavioral change

(3)}
thenpy

In an insulin

chlorpruesim control stuck, no differences in
hospital. immanent ratings were observed in the eve treatmnt gronpl (27).
Chlorpruuine was eater, easier to administer, pernitted continued
coma

«-

administration and allowed for greater degrees or concurrent relatimehip
therapy then insulin

insulin
In.

eon-a.

These observations

cm by psychotropic

drugs

led to a mlaoenent

d

in thin institution.

Phameabherapz.

in evelmting various peyohophamoeutieele is
derived from then methane
and linguistic analyses of
intmenone
of
effects acute
azhinietretien and chronic clinical emu-tration of variom nu compound: are in progress. EEG patterns, along such
The ongoing program

Mamie

continue as eynehmiaatien-deeynahroniuﬂun and tmqnency units are being

related to behavioral (21, 3h,
The neuromyeiologic

141, 1:2)

and

linguistic changes (21,

1:3).

basis of experimentally induced hallucinogenic

etetee have also been interpreted as an alteration in synaptic chemical
relations, such that the effective levels of cholinergic activity is
decreased (ha).

Initial work

on

this hypotheail (21. ha) in

now

being

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�Hillside Hospital
Department of Experimental Psychiatry

Following is a chronologic list of the presentations and
publications of the members of the Department of Emperimental Psychiatry
during 1959.
A.

Publications:
1. Effect of an Anticholinergic Agent, Diethazine, on EEG and Behavior:
Significance for Theory of Convulsive Therapy. Biological
&amp;
Grune
N. Y. pp. 18h-19h
ed.
Masserman,
chiat
P,
Stratton,
J.,
,
(Fink; Egg.
2. Alteration of Brain Fpnction in Therapy. Psychopharmacology Frontiers,
6d. Kline, No, Little, Brown &amp; COO, Boston, pp. 3 Fink, Mo .3. Significance of EEG Pattern Changes in Psychopharmacology.
g(Fink,
)
M. ).
2
:
398
(abst.
Neurophysiol._

EEG

Clin.

h. Effect of Electroconvulsive Therapy on Intractabie Pain. A.M.A. Arch.
Neurol. and Ps chiat. ﬁl: 37-b2 (weinstein, E. A., Kahn, R. L.,
and Eargman, P.5.
5. Electroencephalographic and Behavioral Effects of Tofranil.
Psych. Assoc. J. g; 1665-1718 (Fink, M.).
6.

Canad.

Psychological Factors Affecting Individual Differences in Behavioral
Response to Convulsive Therapy, J. N.M. D. 128: 2h3-2h8 (Fink, M.,
Kahn, R. L., and Pollack, M.).

7. Effects of Diffuse Altered Brain Function on Perception, Phat
Int. Con . Ps chol., Publ. North-Holland, Amsterdam, pp. 23 8- 239
(Fink, M., Kahn, R. L., and Korin, H. ).

8. Complex Visual Perception in Patients with Brain Tumor. Proc. XV Int.
Con . Ps chol., Pub1.North-Holland, Amsterdam, pp. 2 33-237
(gander, M. B., Battersby, w. 3., and Pollack, M. ).

1/5/60

�9. Therapy of Schizophrenia: Role of Alteration of Brain Function on
h92Behavior, Con ess Re orts II Int. Con . Ps chiat
II:
h93 (Abst.
nk, M., Kahn, R. L., and Karin, H.5.
10.

EEG
of
Seizures
of
and
Duration
to
Degree
Threshold
Relationship of
Delta Activity Induced During Electroshock, EEG. Clin. Neurophysiol.
g: 399 (Abst.) (Green, M.).

ll.

Prognostic Application of Psychological Techniques in Convulsive
Therapy, Dis. Nerv. Sys. g9: 180-184 (Kahn, R. L. and Pollack, M.).

12. Communication Networks in Freud's Interview Technique, Psych. Quat.
33: h56-h73 (Jeffe, J.).

13. Sociopsychologic ASpects of Psychiatric Treatment in a Voluntary
Mental Hospital: Duration of Hospitalization, Discha e Ratings
and Diagnosis, A.M.A. Arch. Gen. Ps chiat. l5 565-S7h Kahn, R. L.,
Pollack, M., and Fink, M.5.

Set in the Perception of Simultaneous Tactile Stimuli,
Jour. Psychol. 12.: 38h-392 (Korin, H. and Fink, M.).

The Role of
Am.

Perception Across Sensory Modalities,
(Abst.) (Krauthamer, G.).

Form

Am.

Psychol. lg; 396

16.

Relation of Tests of Altered Brain Function to Behavioral Change
Following Induced Convulsions, The First International Congress
of Neurolo ical Sciences (III: §EG Clinical Neurosﬁgsiology and
Epilepsy5, PBrgamon, London, pp. 513—519 (Fink, M., Kahn, R.L.,
and Karin, H.).

17.

Personality Factors in Behavioral Response to Electroshcnk Therapy,

J. Neuropsychiatgy l; h5-h9

(Kahn, R. L. and

fink,

M=).

18. Symbolic Reorganization in Brain Injuries, in Handbook of Paychiatgy,
ed. Arieti, 3., Basic BOOkS, No Yo, V01. I, pp. 9 "9 l
(Weinstein, E. A. and Kahn, R. L.).

�B.

Presentations:

l.

EEG

and Ebhavioral Effects of Tofranil, International Conference on
Depression and Allied States, Montreal (Fink, M.).

2. Sociopsychologic Factors Affecting Therapist-Patient Relationships,
American Academy of Psychoanalysis, Philadelphia (Kahn, R.L.).
3. Effect of Induced Cerebral Dysfunction in Man on Tachistoscopic
Perception of Embedded Color Figures, Eastern Psychologic
Association, Atlantic City (Pollack, M.).

h. Behavioral Changes with Different Methods of Induced Cerebral
Dysfunction, Eastern Psychological Association, Atlantic City
(Karp,

E.).

5. Sociopsychologic Aspects of Peychiatric Treatment, Eastern
R.
(Kahn,
L.).
City
Atlantic
Association,
Psychological

6. Language Patterns as Measures of Behavioral and Neurophysiologic
Change, American Psychiatric Association, Philadelphia (Fink, M.).
7. Personality Correlates of
(Krauthamer, G.).

EEG,

Metropolitan

EEG

Society,

8. Relation of Social Attitude to Psychiatric Treatment,
Meeting, A.P.A., New York (Kahn, R.L.).

9.

Comparison of

New York

N. Y.

Divisional

Intellectual Functioning in Childhood, Adolescent and

Adult Schizophrenics, N. Y. Divisional Meeting, A.P A.,
(Pollack, M.).

New York

10. Symposium on "Paycholinguistic Analysis of the Psychiai‘ic Interview",
N. Y. Divisional Meeting, A.P.A., New York (Jaffe, :.).
11. Social Background and the Doctor-Patient Relationship, Acad.
Psychoanalysis, New York (Jaffe, J.).

�Hillside Hospital
Department of Experimental Psychiatry

Following is a chronologic list of the presentations and
publications of the members of the Department of Experimental Psychiatry
during 1959.
A.

Publications:
1. Effect of an Anticholinergic Agent, Diethazine, on EEG and Behavior:
Significance for Theory of Convulsive Therapy. Biological
Ps chiat , ed. Masserman, J., Grune &amp; Stratton, N. Y. pp. 18h-19h
(F%:E, M.;.

Alteration of Brain Function in Therapy. Psychopharmacology Frontiers,
ed. Kline, N., Little, Brown &amp; 00., Boston, pp.
-3
, . .
3. Significance of EEG Pattern Changes in FBychopharmacology.
g(Fink,
)
M. ).
398
(abet.
Neurophysiol._2:

EEG

Clin.

.

Effect of Electroconvulsive Theraﬁg on Intr:1ctabm Pai A.M.A. Arch.
Neurol. and ngchiat. Ql: 37- (weinstein, E. A., hahn, R. L.,
and

rgman, P. .

Electroencephalographic and Behavioral Effects of Tofrénil. Canad.
14.3 1663“].715 (Fink, Mo).
ASSOC.
J.
szch.
Psychological Factors Affecting Individual Differences in Behavioral
Reaponse to Convulsive Therapy, J.N.M.D. lag; 2h3-2h8 (Fink, M.,
Kahn, R. L., and Pollack, M.).
7. Effects of Diffuse Altered Brain Function on PercWptio Prsc. XV
Int. Con . P chol., Publ. North-Holland, Amsterdam, pp. 53 3- 239
(335E, M., Kahn, R. L., and Korin, H. ).
Complex Visual Perception in Patients with Brain Tumor. Proc. XV
Cong. Psychol., Publ. North-Holland, Amsterdam, pp. 2 33-?37
n er, M. B., Battersby, w. 3., and Pollack, M. ).

1/5/60

Int.

�“beam,

9. Therapy of Schizophrenia:
Behavior,

h93

C

as

Re

14.,

Alteration of Brain Function on
1:92Con . Ps chia
rts II Int.
II:
,
H321
'£.""‘EER"',
orinL",
‘.
an
hn,

Role of

10.

Relationship of Threshold and Duration of Seizures to Degree of EEG
Delta Activity Induced During Electroshoclc, EEG. Olin. Neurophzsiol.
_2_: 399 (Abst.) (Green, M.).

11.

Progncs tic Application

of Psychological Techniques in Convulsive
Therapy, Dis. Nerv. Sys. g9: 180-184 (Kahn, R. L. and Pollack, M.).

12. Communication Networks in Freud’s Interview Technique, Psych. Bust.
23: 156-1473 (Jaﬁ‘e, J.).
13. Sociopsychologic Aspects of Psychiatric Treatment in a Voluntary
Mental Hospital: Duration of Hospitalization, Discha e Ratings
and Diag10818, AeMeAe Arch. Gene P3 Chiate ;: 565-571; Kahn, Re Lo,

Pollack,

M. '.
14., and—Tink"—‘T,

1h. The Role of Set in the Perception of Simultaneous Tactile Stimuli,
Am. Jour. Psychol. 1g: 38h-392 (Korin, H. and Fink, M.).

tion Across Sensory Modalities,

Psychol. 3;: 396

15.

Form Perce

16.

Relation of Tests of Altered Brain Function to Behavioral Change
Following Induced Convulsions, The First Internatior; 3.1 Congress
of Neurolo ica3_Sciences (LII: EEG, Clinical Neurop._,jsiolog and
Epilepsy), ﬁrgamon, London, pp. 13- 19 ink, M. , v-iahn, R.L.,
and Karin, H.) .

(Abst. (Krauthamer, G.).

Am.

1?. Personality Factors in Behavioral Response to Electroshntrk Therapy,
J. Neuropgychiatg l: h5-h9 (Kahn, R. L. and :nk, ).
18. Symbolic Reorganization in Brain Injuries, in Handbook of Pa hia
ed. Arieti, 3., Basic Books, N. Y., Vol. I, pp. '935-931
(Weinstein, E. A. and Kahn, Re Le).

;

�B.

Presentations:
1.

EEG

and Behavioral Effects of Tofranil, International Conference on
Depression and Allied States, Montreal (Fink, M.).

2. Sociopsychologic Factors Affecting Therapist-Patient Relationships,
American Academy of Psychoanalysis, Fhiladelphia (Kahn, R.L.).
Man
on Tachistoscopic
Cerebral
Induced
in
Dysfunction
of
3. Effect
Perception of Embedded Color Figures, Eastern Paychologic
Association, Atlantic City (Pollack, M.).

h. Behavioral Changes with Different Methods of Induced Cerebral
Dysfunction, Eastern Psychological Association, Atlantic City
(Karp, E0).

5. Sociopsychologic Aspects of Paychiatric Treatment, Eastern
R.
(Kahn,
L.).
City
Atlantic
Association,
Psycholqgical

6. Language Patterns as Measures of Behavioral and Neurophysiologic
M.).
(Fink,
American
Fhiladelphia
Association,
Paychiatric
Change,
7. Personality Correlates of
(Krauthamer, G.).

EEG,

Metropolitan

LEG

Society,

8. Relation of Social Attitude to Psychiatric Treatment,
Meeting, A.P.A., New York (Kahn, R.L.).

9.

Comparison of

New York

N. Y.

Divisional

Intellectual Functioning in Childhood, Adolescent and

Adult Schizophrenics, N. Y. Divisional Meeting, A.P,A.,
(Pollack, M.).

New York

10. Symposium on "Pbycholinguistic Analysis of the Piychiai-ic Interview",
N. Y. Divisional Meeting, A.P.A., New York (Jaffe, q.).
11. Social Background and the Doctor-Patient Relationship, Acad.
Psychoanalysis, New York (Jaffe, J.).

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