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                  <text>January 12, 1997
Dear Jack,
It was good to hear from you again; I also received a card from Sophie and
her family on holiday. All is well here. Martha has just returned from a short visit to our
two grandchildren in Phoenix. The are growing well and the reports were glowing. My
son, as a Department chairman, is in that phase of his life that he is dealing with ‘movers
and shakers’ -- deans, university presidents, and corporate executives. He likes the power.
At the same time, he is at a pinnacle of his research career, with much research money
and many students, and has to decide which effort -- the academic or the political -- to
follow. Martha reminds me that I was in the same phase when I was in Missouri as the
head of an institute. I am glad I chose the research.
On the topic of research, a few years ago I urged some leaders in ECT to
organize a study comparing the efﬁcacy of continuation ECT to that of continuation
medications [lithium and a tricyclic]. After three years of bargaining, the Government has
awarded grants to four hospitals in a collaborative effort. Unfortunately, the federal funds
are inadequate to do the study properly. In the past, universities were willing to support
the research effort, seeing such work as part of their academic responsibility. No longer.
The issue now is wholly -— how much money do you bring in as a clinician; how much
are we paying you; and if we cannot make a proﬁt, maybe it is time to go. So, I am in the
process of returning the money to NIMH.
The process has become ugly. The Dean has asked whether I am willing to
retire now. After all, he says, he can hire two psychiatrists for my salary. When I noted
that I have been accorded all sorts of honors as a teacher and as a leader in research, he
smiled and said that the school had paid me for such efforts in the past, but for me to ‘get
with it’ -- the times have changed. Martha and I have begun the necessary dialogue to
retire later this year, after I have completed my present assignments. These end in June
and after some months of terminal leave, I should be free.
My book ELECTROSHOCK is coming along nicely. I have written a
for
the laity. I have a good publisher [Oxford University Press]. All the main
description
chapters are written; I am busy with the end-notes and appendices. While it will not lead
many to this useful treatment, it will serve to answer some questions.

�As with my university, a similar immediate return seems to have affected
old
your
company. Earlier in the year, when mirtazepine [ORG 3770] was about to be
marketed, I reached the research director at Organon USA and suggested that we
undertake a clinical trial of mirtazepine in delusional depressed patients, with an eye to
deﬁning its efﬁcacy in hospitalized patients. I noted that the ﬁling data in the US. [which
he had sent me] was limited to out—patients. In return, he said that they were not at all
interested in testing mirtazepine in in—patients. [I do miss the days when it was possible to
talk directly to Organon’s leaders]
I replied that I ran a clinic of depressed patients and I offered to examine
mirtazepine in either our depressed patients after a course of ECT [was it as effective as a
tricyclic in continuation treatrnent?] or in those who were not so ill, and for whom we
could deﬁne the clinical efﬁcacy at the same time as its effects on adrenal functions.

Again, he wrote to say that they were not interested. Too bad. The competition for
attention in modern psychopharmacology is based wholly on hiring ‘names’ to give
‘talks’ about new drugs and to ‘testify’ as to their effects. Most of my peers are already
on the do g-leash for other compounds [of which there are about eight]. I fear that
mirtazepine will have no better fate than mianserin in this country.

Martha continues her supervision of student teachers; our daughter Rachel
in Massachusetts has adopted a lovely, bright, and intelligent Chinese girl whom we love.
And Linda has convinced her husband to take a position in Virginia -- they are building
their home on almost 200 acres of mountain-top nearby to her college.
I continue to give courses in ECT and lecture on my new-found interest,
the syndrome of catatonia. Martha and I are off to Melbourne in late February. That will
be our ﬁrst trip to Australia.
So, we move on from one phase to another. When I step down, it should
be possible to travel more freely. We will see. Meanwhile, Martha joins me in thanking
you for your kind note, and we wish you and your family continuing health in 1997.

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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