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                  <text>December 27, 1993
TO:

F aroukh Maneksha

George Petrides
From:

Max Fink

Subject:

Follow—up

on trimethaphan study

Now that the dose range of trimethaphan has been deﬁned, we should use a
similar design to study the relative efficacy [and safety] of a beta-blocker compared to
trimethaphan.
Attached is the output of abstracts from a search of the ECT Database for
the substances labetalol, esmolol, and nitroglycerine, post-1987. Would you review
these and select one as a contrast for trimethaphan? Can you define a-commonly used
dose? Is there a design that you favor?

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              <text>1992 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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