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["1513

Wednesday May 15, 3:00 p.m.-5:00 p.m.
Side
Effects of Methylphenidate (Ritalin)
Efficacy and
for Post-Stroke Depression
Lawrence W. Lazarus, M.D., Psychiatry, Rush- Pres- St.
Luke's, 1653 West Congress Parkway, Chicago, IL 60612;
David Winemiller, B.S., Venkata Lingam, M.D., Carolyn
Hartman, M.D., Ida Neyman, M.D., Mehrdad Abbassian, M.D.,
Usha Kartan, M.D., Pauline Langsley, M.D., Virginia Markvart,
Fi.N., Jan Fawcett, M.D.
Summary:
Large numbers of stroke victims suffer significant depression
within the ﬁrst two years following stroke. Use of tricyclic antidepressants among elderly patients is often complicated by side effects
such as orthostatic hypotension. Methylphenidate has been shown
to be a rapid , safe, and effective treatment for depressed geriatric
patients.
Methylphenidatewas studied for safety and efficacy in the treatment of post-stroke depression at Rush-Presbyterian-St. Luke’s
Medical Center in Chicago. Ten elderly stroke patients with a DSMIll-R diagnOsis of major depressive disorder, a minimum Hamilton
Depression Rating Scale score of 15, and a minimum Mini Mental
Status score of 14 were treated with methylphenidate and studied
for three weeks.
Four of the 10 subjects showed Hamilton score reductions of
50% or greater. An additional four subjects showed Hamilton score
reductions of at least 25%. No subject had adverse side effects
necessitating discontinuation from the study. Five of the 10 subjects reported between one and three individual side effects.
Methylphenidate appears to be a safe and effective treatment
for elderly patients with post-stroke depression. Its rapid onset of
action and relatively low side effect profile may offer advantages
over tricyclic antidepressants, particularly in a rehabilitation or acute
medical hospital setting.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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