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March 31, 1987

Robert Martz, M.D.

Group Director- CNS Diseases
Du Pont - Medical Products Department
Wilmington, Delaware 19898
Dear Dr. Martz,
I thought that I had sent a copy of our response to the FDA regarding 1ND
21,821 to you, but I may not have.

in response to a request from the FDA in June, 1986, I noted our failure to
EEG or the behavior of our psychiatric patients during the course of
convulsive therapy by doses of naioxone up to 20 mg. As our findings were
consistent with other reports, we discontinued the study. We have not published the
results of our experience. The remaining supplies of naloxone were outdated and

affect the

destroyed.

Copies of our formal notiﬁcation of the FDA and their reply are enclosed.
Thank you very much for your cooperation and assistance in the study.

Sincerely yours,
Max Fink, M.D.

Professor of Psychiatry

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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