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                  <text>January 26,

19 35

Morton F. Reiser, M.D.
Department of Psychiatry
Yale University School of Medicine

25 Park

Street

New Haven, CT 06519
Dear Mort,
I

am pleased to write this letter strongly endorsing the promotion of

DENNIS CHARNEY, Md). to the rank of Associate Professor of Psychiatry. I have

known of his work since his important reports with Nelson on delusional depression.
As I hold an IND for research studies with mianserin, I have also cooperated with
him in making the substance available to him, and in providing the FDA backup for
his studies. And, I have come to know him from his presentations at the APA and
ACNP.
His studies of delusional depression have been useful in defining the

characteristics of patients (with delusions) who do not respond as anticipated to
tricyclic drugs, and for whom other treatments are required. His subsequent work

with clonidlne, yohimbine, mianserin, haltrexone, and most recently, the trials of
lithium and antidepressants in the treatment of refractory depressions are
innovative, thoughtful, and logically derived from monoaminergic theories of
antidepressant drug actions. His studies are well designed, and on the occasions
when I have had the opportunity to review them prior to publication, have had no
difficulty in recommending their publication.
Dennis is clearly one of the outstanding students of depressive disorders,
with a keen grasp of modern theories and research design. My only regret is that he
has not (as yet) shown an interest in convulsive therapy, for I am confident that he
would make important contributions to ow understanding of that therapy which
remains the most effective treatment of delusional depression.
My

best regards.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

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