http://exhibits.library.stonybrook.edu/mfp/files/original/a0aeef0042fc56e7b4c051ba29c74ac7.pdf 5da6dba43645def2154261add4f2dae3 PDF Text Text I1 mm.--.-..m-w1 March 9, 1985 Mr. Peter Irwin Medical Research Department Sandoz Inc. Hanover, New Jersey Dear Peter, I read the article by Glassman st 31. and react much as you did. There is as much evidence that drowsiness was the active component in the effects on craving as that a specific biochemical process was responsible. But it seems difficult to attack the conclusions based on these data alone. I seem to recall that our subjects, given clonidine, also had a significant degree of drowsiness, as did our subjects when given higher doses of diazepam and bromazepam. Also, the time course of our experience would be applicable. In order to do justice to a critique of this report, I think we would have to extract some of our own data, see if they are relevant, and make a more compelling case than your argument. The dependence on the PDR does not have much cachet; indeed, it is not considered a relable source of scientific information, being seen as a negotiated average of sentiments between legal partisans from industry and less-than-competent administrative bureaucrats. Such an argument may have place in the board-rooms of industry or the law courts, but hardly in SCIENCE. am so busy with convulsive therapy, that Glassman's peccadillos and the pseudo-science of SCIENCE influence me little. I The historical paper which I wrote for IPEG in memory of Bente has been published. I enclose a copy for your bulletin-board. The IBM 1800 is acting up again, and i am getting desparate to end it all, either by decapitating the machine and chucking all the work, or by replacing it with the H21 IBM-AT based system. I am visiting HZI next week to see if there is some fire where there has been nil-smoke for so long. Meanwhile, Itil has convinced Hoffmann-La Roche that he can distinguish three formulations of Valium; they have petitioned the FDA to change the among rules on generics and look-alikes by requiring pharmacodynamic equivalence as well as pharmacokinetic and chemical dissolution equivalence. The petition went in two weeks ago; you can read all about it in the pink sheets. if the FDA is convinced and changes the regulations, industry will need our pharmaco-EEG studies as much as they needed the sleep-EEG studies when the FDA accepted such studies as evidence of soporific activity. If the FDA acts favorably, I will get my new AT system; and you could go into business for yourself with little investment. Keep the faith. My best regards. Sincerely yours, “it � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Irwin, Peter Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-030-6-182 Date A point or period of time associated with an event in the lifecycle of the resource 1985 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence