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                  <text>“ﬁve.” .w... 7w, W, _”.,.....~

“W'mmwmn—

77“

.. ., .V..,-.-.v.—-:-u-n

rwwmwvww.

December 30, 1985
Samuel Gershon, MJ).

Professor 6t Chairman
Department of Psychiatry
Wayne State University 6c Lafayette Clinic
951 East Lafayette
Detroit, Michigan #8202
Dear Sam,

It was fun being with you and Lisl in Maui. We trust your visits to Australia
were as pleasant as the days in Hawaii. Let's get together when next you spend
some days with Bernard in New York.
I did attend the session at which Bob Friedel presented his data on the
greater efficacy of the combination of thiothixene and ECT than thiothixene alone
in 'therapy-resistant' schizophrenic patients. The first question was asked by
Seymour Katy and Bob answered that a possible mechanism of action was greater

penetrance of thiothixene because ECT induces a reduction in the integrity of the
blood-brain barrier.
'

The principal studies of blood brain barrier and seizures are cited in the
i enclose. The principal scientist
behind recent studies is Thomas Bolwig, M.D.(Psychochemistry Institute,
Rigshospitalet, 9, Blegdamsvej, DK-2100 Copenhagen, Denmark). He is an old
friend and lam confident that he will answer any inquiries directly.

attached list and in the three abstracts which

Following your suggestion, I would be very much interested in a well
designed and controlled examination of this hypothesis in animals. The findings are
clearly publishable, and CONVULSIVE THERAPY is clearly interested in the
findings.
My best wishes for the continued success of the Lafayette Clinic, and my
best regards.

Sincerely yours,

Max Fink, M.D.

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              <text>1984 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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