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                  <text>av

1w.v‘~rrhnmr.‘~£—I

A-

v.

May 23, 1984

Joel E. Dimsdale, M.D.
Department of Psychiatry
Massachusetts General Hospital
Fruit Street
Boston, Massachusetts 02114
Dear Joel,
I am pleased to enclose some reprints of our quantitative EEG studies. We
have not published our studies with antihypertensive drugs, although we have
completed assays of propranolol, l-penbutolol (Betapressin), and azepexole. I will be
presenting these findings at the CINP meetings in Florence at the end of June, but
have not yet written the paper.

In the meanwhile, the techniques are clearly sensitive to the CNS effects
of these substances. Each affects brain function at doses which are clinically
relevant, and do so in normotensive male volunteers. Preliminary reports of studies
in progress in elderly hypertensives define CNS effects which are strongly sedative
in type. These have been done by Kleindienst at Hoechst (Frankfurt), Matecjek and
Irwin at Sandoz (Basie), and Herrmann (Berlin). I anticipate that they will be
presenting their findings this year as well.
My

regards.
Sincerely yours,

Max Fink, M.D.

Professor of Psychiatry

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