http://exhibits.library.stonybrook.edu/mfp/files/original/2ee2f5e0e3b28672e37d9276fb0a19e4.pdf 4b9bfd0e70678640a7290df171163c9b PDF Text Text March 1, 1983 Penelope Bowers, MD. Boehringer lngelheim, Ltd. 90 East Ridge P.O. Box 368 Ridgefield, CT 06877 Dear Penny, Enclosed are draft copies of the report, "Pharmaco-EEG Analysis of clonidine (Catapres): Comparison with l-Penbutolol (Betapressin)". The report summarizes the experiences in the two studies of Catapres which we have completed in normal male volunteers. Catapres exhibits central effects at single doses of 0.075 mg which peak at two hours after dosing and are no longer measurable at four hours. The EEG pattern are those of a sedative or hypnotic, and are not consistent with the changes seen with typical antipsychotic, antidepressant (thymoleptic), or anxiolytic psychoactive substances. In these trials, Catapres elicited some lowering of systolic and diastolic blood pressures and a slowing of the heart rate. These findings suggest that Catapres elicits direct effects in the CNS, in doses which may be clinically relevant. A summary of the first study was presented at the ACNP session on organized by Dr. Richard Resnick, and was published in Psychooharmacology Bulletin (31:16-17, 1981). Do you think a more detailed report Catapres should be prepared for publication based on these findings '? Thank you for the opportunity to carry out these trials with this interesting and useful medicinal. My best regards. Sincerely yours, Max Fink, MD. Professor of Psychiatry ~ .. m- ;.. Mn": mytno-ppxmmww.“marginaqwng � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Bowers, Penelope Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-030-3-075 Date A point or period of time associated with an event in the lifecycle of the resource 1983 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence