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                  <text>May 25, 1983

Turan M. itil, M.D.
HZI Research
150

White Plains Road

Tarrytown, New York 10591
Dear Turan,
l have been puzzled by the evidence for the nobtropic class of
psychoactive substances. Using pharmaco-EEG methods, I studied a number of the
peptides for which a nobtropic status has been claimed. I was unable to elicit either
an EEG profile or evidence of behavioral effects. I have also read the literature,
and found the published data until 1981 thin and unpromising.

Lately, you have published an editorial supporting such a classification -but the editorial lacked the evidence for the claim.
I recently came across the citation list for the special issue of Drug
Development Research (2 (5), 1982) which has a number of titles which suggest
that they might contain the evidence for such a classification. 1 requested a copy.
of the journal from our library, and we have no subscription; I requested an
interlibrary loan, but as an unbound journal, it is not available. Hence this letter.

Do you have a copy of the issue ? Would you lend
Many thanks.

it to me for a few days

?

We began our first patient on Sertraline on Monday of this week. (We
actually began two, but when I checked the inclusion criteria, one patient was 70
years of age, and Dr. Gholly rejected her.) I also sent a protocol for an EEG study
for BHT 933 (azepexole) to Penny, and hope to examine it this Fall.
I trust Ellen and the children are well. We expect Jon next week, and
Rachel said that she may fly up to visit with her brother as well. I cannot get to
the NCDEU meetings this year, so will miss all the sunshine.
My

best regards.
Sincerely yours,
Max Fink, M.D.

�</text>
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